pain threshold

Summary

Summary: Amount of stimulation required before the sensation of pain is experienced.

Top Publications

  1. ncbi Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values
    R Rolke
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Pain 123:231-43. 2006
  2. ncbi Sensitization in patients with painful knee osteoarthritis
    Lars Arendt-Nielsen
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Pain 149:573-81. 2010
  3. ncbi Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity
    R R Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Rm 4309, Charlestown, Massachusetts 02129, USA
    Nat Neurosci 2:1114-9. 1999
  4. ncbi Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143 0450, USA
    Science 288:306-13. 2000
  5. pmc JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain
    Yong Jing Gao
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 29:4096-108. 2009
  6. ncbi Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes
    C Maier
    Department of Pain Management, BG Universitätsklinikum Bergmannsheil GmbH, Ruhr University, Bochum, Germany
    Pain 150:439-50. 2010
  7. ncbi Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy
    David Yarnitsky
    Department of Neurology, Rambam Health Care Campus, Haifa, Israel
    Pain 153:1193-8. 2012
  8. ncbi Human evidence of a supra-spinal modulating role of dopamine on pain perception
    Stephane Potvin
    Department of Neurosurgery, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Canada
    Synapse 63:390-402. 2009
  9. ncbi Noradrenergic pain modulation
    Antti Pertovaara
    Biomedicum Helsinki, Institute of Biomedicine Physiology, PO Box 63, University of Helsinki, FIN 00014 Helsinki, Finland
    Prog Neurobiol 80:53-83. 2006
  10. pmc Episodic and chronic migraineurs are hypersensitive to thermal stimuli between migraine attacks
    Todd J Schwedt
    Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cephalalgia 31:6-12. 2011

Detail Information

Publications342 found, 100 shown here

  1. ncbi Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values
    R Rolke
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Pain 123:231-43. 2006
    ..Application of this standardized QST protocol in patients and human surrogate models will allow to infer underlying mechanisms from somatosensory phenotypes...
  2. ncbi Sensitization in patients with painful knee osteoarthritis
    Lars Arendt-Nielsen
    Center for Sensory Motor Interaction SMI, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    Pain 149:573-81. 2010
    ..This study highlights the importance of central sensitization as an important manifestation in knee OA...
  3. ncbi Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity
    R R Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Rm 4309, Charlestown, Massachusetts 02129, USA
    Nat Neurosci 2:1114-9. 1999
    ..ERK signaling within the spinal cord is therefore involved in generating pain hypersensitivity. Because of its rapid activation, this effect probably involves regulation of neuronal excitability without changes in transcription...
  4. ncbi Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143 0450, USA
    Science 288:306-13. 2000
    ..Thus, VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia...
  5. pmc JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain
    Yong Jing Gao
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 29:4096-108. 2009
    ..Inhibition of the JNK/MCP-1 pathway may provide a new therapy for neuropathic pain management...
  6. ncbi Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes
    C Maier
    Department of Pain Management, BG Universitätsklinikum Bergmannsheil GmbH, Ruhr University, Bochum, Germany
    Pain 150:439-50. 2010
    ..The characterization of underlying mechanisms will be needed to make a mechanism-based classification feasible...
  7. ncbi Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy
    David Yarnitsky
    Department of Neurology, Rambam Health Care Campus, Haifa, Israel
    Pain 153:1193-8. 2012
    ..In conclusion, the coupling of CPM and duloxetine efficacy highlights the importance of pain pathophysiology in the clinical decision-making process. This evaluative approach promotes personalized pain therapy...
  8. ncbi Human evidence of a supra-spinal modulating role of dopamine on pain perception
    Stephane Potvin
    Department of Neurosurgery, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Canada
    Synapse 63:390-402. 2009
    ..Recently, a series of studies explored the function of dopamine in pain perception, which we review here, while focusing on human studies...
  9. ncbi Noradrenergic pain modulation
    Antti Pertovaara
    Biomedicum Helsinki, Institute of Biomedicine Physiology, PO Box 63, University of Helsinki, FIN 00014 Helsinki, Finland
    Prog Neurobiol 80:53-83. 2006
    ..Following injury or inflammation, the central as well as peripheral noradrenergic system is subject to various plastic changes that influence its antinociceptive efficacy...
  10. pmc Episodic and chronic migraineurs are hypersensitive to thermal stimuli between migraine attacks
    Todd J Schwedt
    Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cephalalgia 31:6-12. 2011
    ..To determine if migraineurs have evidence of interictal cutaneous sensitisation...
  11. ncbi Sleep loss and REM sleep loss are hyperalgesic
    Timothy Roehrs
    Henry Ford Health System, Sleep Disorders and Research Center, Detroit, MI 48202, USA
    Sleep 29:145-51. 2006
    ..We report the first data showing, in healthy, pain-free, individuals, that modest reductions of sleep time and specific loss of rapid eye movement (REM) sleep produces hyperalgesia the following morning...
  12. ncbi Neurogenic hyperalgesia versus painful hypoalgesia: two distinct mechanisms of neuropathic pain
    Ulf Baumgartner
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Pain 96:141-51. 2002
    ..a continuous distribution of threshold shifts in the dysaesthetic skin area with a low to moderate increase in pain threshold (by 1.52+/-0.45 log2 units)...
  13. ncbi Evidence of augmented central pain processing in idiopathic chronic low back pain
    Thorsten Giesecke
    University of Michigan, Ann Arbor, MI 48106, USA
    Arthritis Rheum 50:613-23. 2004
    ..We compared the results of both of these methods as applied to patients with idiopathic CLBP (n = 11), patients with widespread pain (fibromyalgia; n = 16), and healthy control subjects (n = 11)...
  14. pmc Sex, gender, and pain: an overview of a complex field
    Robert W Hurley
    Department of Anesthesiology and Critical Care Medicine, Division of Pain Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Anesth Analg 107:309-17. 2008
    ..The present state of the literature allows no translation of the work to our clinical decision-making...
  15. ncbi Experimental and clinical applications of quantitative sensory testing applied to skin, muscles and viscera
    Lars Arendt-Nielsen
    Department of Health Sciences and Technology, Center for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark
    J Pain 10:556-72. 2009
    ..Assessing pain has become a question of solving a multi-input, multi-output problem, with the solution providing the possibility of teasing out which pain pathways and mechanisms are involved, impaired, or affected...
  16. ncbi Spontaneous pain, pain threshold, and pain tolerance in Parkinson's disease
    Sandro Zambito Marsala
    Neurology Unit, San Martino Hospital, Belluno, Italy
    J Neurol 258:627-33. 2011
    ..Although a few studies have reported that PD patients may have low pain threshold and tolerance, none could accurately assess whether there was a correlation between sensory thresholds and ..
  17. ncbi Quantitative sensory testing: a comprehensive protocol for clinical trials
    R Rolke
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Saarstr 21, D 55099 Mainz, Germany
    Eur J Pain 10:77-88. 2006
    ..Case examples of selected patients illustrate the value of z-transformed QST data for an easy survey of individual symptom profiles...
  18. ncbi Pain threshold variations in somatic wall tissues as a function of menstrual cycle, segmental site and tissue depth in non-dysmenorrheic women, dysmenorrheic women and men
    M A Giamberardino
    Pathophysiology of Pain Laboratory, Institute of Medical Pathophysiology, G D Annunzio University of Chieti, Italy
    Pain 71:187-97. 1997
    ....
  19. pmc Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: a randomized, double-blind, placebo-controlled study
    Roland Staud
    Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    Pain 145:96-104. 2009
    ..02). Neither lidocaine nor saline injections significantly affected clinical FM pain ratings, a result most likely due to the very low dose of lidocaine (50mg) used in this trial...
  20. ncbi Bilateral widespread mechanical pain sensitivity in carpal tunnel syndrome: evidence of central processing in unilateral neuropathy
    César Fernández-de-Las-Peñas
    Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Avenida de Atenas s n, Alcorcon, Madrid, Spain
    Brain 132:1472-9. 2009
    ..The results showed that pressure pain threshold levels were significantly decreased bilaterally over the median, ulnar, and radial nerve trunks, the carpal ..
  21. ncbi Quantitative sensory testing profiles in chronic back pain are distinct from those in fibromyalgia
    Klaus Blumenstiel
    Department of General Internal Medicine and Psychosomatics, Medical Hospital, Ruprecht Karls University Heidelberg, Germany
    Clin J Pain 27:682-90. 2011
    ..The aim of this study was to disclose commonalities and differences in the pathophysiology of FMS and CBP...
  22. ncbi Randomised clinical trial: pregabalin attenuates experimental visceral pain through sub-cortical mechanisms in patients with painful chronic pancreatitis
    S S Olesen
    Mech Sense, Department of Gastroenterology, Aalborg Hospital, Aarhus University Hospital, Denmark
    Aliment Pharmacol Ther 34:878-87. 2011
    ..Pregabalin has a broad spectrum of analgesic and antihyperalgesic activity in both basic and clinical studies. However, its mechanisms and sites of action have yet to be determined in humans...
  23. ncbi The effects of sleep deprivation on pain inhibition and spontaneous pain in women
    Michael T Smith
    Behavioral Sleep Medicine Program, Johns Hopkins Bayview, Johns Hopkins University School of Medicine, Baltimore MD 21287, USA
    Sleep 30:494-505. 2007
    ....
  24. ncbi Reference data for quantitative sensory testing (QST): refined stratification for age and a novel method for statistical comparison of group data
    Walter Magerl
    Department of Neurophysiology, Center for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Ludolf Krehl Strasse 13 17, 68167 Mannheim, Germany
    Pain 151:598-605. 2010
    ..This technique makes the DFNS reference data bank applicable for researchers beyond the DFNS community without a need for subsampling of subjects from the database...
  25. ncbi Individual differences in pain sensitivity: genetic and environmental contributions
    Christopher S Nielsen
    Division of Mental Health, Norwegian Institute of Public Health, P O Box 4404 Nydalen, NO 0403 Oslo, Norway
    Pain 136:21-9. 2008
    ..It also indicates that differences in pain scale usage account for a minor portion of the variance, providing strong support for the validity of subjective pain ratings as measures of experienced pain...
  26. ncbi Pain elicited by blunt pressure: neurobiological basis and clinical relevance
    R D Treede
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Saarstrasse 21, D 55099, Mainz, Germany
    Pain 98:235-40. 2002
  27. ncbi Sex differences in the perception of noxious experimental stimuli: a meta-analysis
    J L Riley
    Claude Pepper Center for Research of Oral Health in Aging, University of Florida, Gainesville 32610, USA
    Pain 74:181-7. 1998
    ..The results of this study compels to caution authors to obtain adequate sample sizes and hope that this meta-analytic review can aid in the determination of sample size for future studies...
  28. ncbi The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans
    Roger B Fillingim
    University of Florida College of Dentistry, Gainesville, FL 32610, USA
    J Pain 6:159-67. 2005
    ..The results indicate that the rare allele is associated with higher pressure pain thresholds. These results support previous contentions that OPRM1 may be a pain-relevant gene; however, replication of these findings is needed...
  29. pmc Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors
    Andrea Gail Nackley
    Center for Neurosensory Disorders, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
    Pain 128:199-208. 2007
    ....
  30. ncbi Test-retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS): a multi-centre study
    Christian Geber
    Klinik und Poliklinik fur Neurologie, Universitätsmedizin der Johannes Gutenberg Universität, Mainz, Germany
    Pain 152:548-56. 2011
    ....
  31. pmc Effect of a second-generation alpha2delta ligand (pregabalin) on visceral sensation in hypersensitive patients with irritable bowel syndrome
    L A Houghton
    Neurogastroenterology Unit, Academic Division of Medicine and Surgery, University of Manchester, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK
    Gut 56:1218-25. 2007
    ..Pre-clinical studies suggest that the alpha(2)delta ligand pregabalin reduces both visceral allodynia and hyperalgesia, but is inactive on basal sensitivity...
  32. ncbi No relationship between the ins del polymorphism of the serotonin transporter promoter and pain perception in fibromyalgia patients and healthy controls
    Stephane Potvin
    Service of Neurosurgery, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Canada
    Eur J Pain 14:742-6. 2010
    ....
  33. ncbi Do opioids induce hyperalgesia in humans? An evidence-based structured review
    David A Fishbain
    Department of Psychiatry, Miller School of Medicine at the University of Miami, Florida 33136, USA
    Pain Med 10:829-39. 2009
    DESIGN/OBJECTIVES: Consistent rodent evidence indicates that opioid exposure will decrease the rodent's pain threshold (ptr). This is termed opioids-induced hyperalgesia (OIH)...
  34. ncbi New method for quantification and statistical analysis of nociceptive reflex receptive fields in humans
    Alban Y Neziri
    University Dept of Anaesthesiology and Pain Therapy, University Hospital of Berne, Inselspital, Switzerland
    J Neurosci Methods 178:24-30. 2009
    ..It may be utilized as a new diagnostic tool for central hypersensitivity and quantification of therapeutic interventions...
  35. ncbi The effect of the menstrual cycle on affective modulation of pain and nociception in healthy women
    Jamie L Rhudy
    Department of Psychology, The University of Tulsa, USA
    Pain 149:365-72. 2010
    ..g., premenstrual dysphoric disorder, fibromyalgia)...
  36. pmc Dopamine transporter genotype dependent effects of apomorphine on cold pain tolerance in healthy volunteers
    Roi Treister
    The Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    PLoS ONE 8:e63808. 2013
    ..Heat pain threshold and intensity, cold pain threshold, and the response to tonic cold pain (latency, intensity, and tolerance) ..
  37. ncbi T lymphocytes containing β-endorphin ameliorate mechanical hypersensitivity following nerve injury
    Dominika Labuz
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Krahmerstrasse 6, Berlin, Germany
    Brain Behav Immun 24:1045-53. 2010
    ..Our findings reveal β-endorphin-containing T cells as a crucial component of beneficial adaptive immune responses associated with painful peripheral nerve injuries...
  38. ncbi Hand dominancy--a feature affecting sensitivity to pain
    Dorit Pud
    Faculty of Social Welfare and Health Sciences, University of Haifa, Mount Carmel, Haifa 31905, Israel
    Neurosci Lett 467:237-40. 2009
    ..Subjects were exposed to the cold pressor test (1 degrees C) for both hands while measuring the cold pain threshold, intensity, and tolerance...
  39. ncbi Generalized expansion of nociceptive reflex receptive fields in chronic pain patients
    Alban Y Neziri
    University Department of Anesthesiology and Pain Therapy, University Hospital of Bern, Inselspital, 3010 Bern, Switzerland
    Pain 151:798-805. 2010
    ..Reverting the expansion of nociceptive receptive fields and exploring the prognostic meaning of this phenomenon may become future targets of clinical research...
  40. ncbi Involvement of spinal cord BDNF in the generation and maintenance of chronic neuropathic pain in rats
    Luis Constandil
    Laboratorio de Neurobiologia, Departamento de Biologia, Facultad de Quimica y Biologia, Universidad de Santiago de Chile, Santiago, Chile
    Brain Res Bull 86:454-9. 2011
    ..dose or administering additional doses of BDNF resulted neither in additional effectiveness in reducing the pain threshold nor in the prolongation of the hyperalgesic effect, thus showing that central sensitization induced by BDNF is ..
  41. pmc Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain
    Milena De Felice
    Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Pain 152:2701-9. 2011
    ..Engagement of descending inhibition protects in the transition from acute to chronic pain. These unexpected findings might provide a mechanistic explanation for medications that engage descending inhibition or mimic its consequences...
  42. ncbi Assessment and analysis of mechanical allodynia-like behavior induced by spared nerve injury (SNI) in the mouse
    Anne Frédérique Bourquin
    Anesthesiology Pain Research Group, Department of Anesthesiology, Lausanne University Hospital CHUV, CH 1011 Lausanne, Switzerland
    Pain 122:14.e1-14. 2006
    ..Use of this model in genetically altered mice should be very effective for determining the mechanisms involved in neuropathic pain...
  43. pmc Conditioned pain modulation is associated with common polymorphisms in the serotonin transporter gene
    Fredrik Lindstedt
    Department of Clinical Neuroscience, Osher Center for Integrative Medicine, Stockholm Brain Institute, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e18252. 2011
    ..Individualized noxious heat and pressure pain thresholds (PPTs) were used as subjective test-modalities and the nociceptive flexion reflex (NFR) was used to provide an objective neurophysiological window into spinal processing...
  44. pmc Influence of headache frequency on clinical signs and symptoms of TMD in subjects with temple headache and TMD pain
    Gary C Anderson
    University of Minnesota School of Dentistry, Department of Developmental and Surgical Sciences, Minneapolis, MN 55455, USA
    Pain 152:765-71. 2011
    ..In conclusion, these findings suggest that these headaches may be TMD related, as well as suggesting a possible role for peripheral and central sensitization in TMD patients...
  45. ncbi Apomorphine effect on pain threshold in Parkinson's disease: a clinical and positron emission tomography study
    Estelle Dellapina
    INSERM, Imagerie cérébrale et handicaps neurologiques, Toulouse, France
    Mov Disord 26:153-7. 2011
    ..Subjective pain threshold (using thermal stimulation, thermotest), objective pain threshold (nociceptive flexion reflex), and cerebral ..
  46. pmc Pain sensitivity and modulation in primary insomnia
    M Haack
    Beth Israel Medical Deaconess Center and Harvard Medical School, Boston, MA, USA
    Eur J Pain 16:522-33. 2012
    ..This constant activation ultimately may result in a ceiling effect of pain-inhibitory efforts, as indicated by the inability of the system to adequately function during challenge...
  47. pmc Dissociation of thermal hypoalgesia and epidermal denervation in streptozotocin-diabetic mice
    Kristina K Beiswenger
    Department of Pathology 0612, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0612, United States
    Neurosci Lett 442:267-72. 2008
    ..These data suggest that impaired epidermal nociceptor function contributes to early diabetes-induced thermal hypoalgesia prior to the loss of peripheral terminals...
  48. pmc Enhanced sensitivity to punctate painful stimuli in female patients with chronic low back pain
    Christian Puta
    Department of Sports Medicine and Health Promotion, Friedrich Schiller University, Wöllnitzer Strasse 42, Jena D 07749, Germany
    BMC Neurol 12:98. 2012
    ..The aim of the present study was to investigate signs of generalized mechanical pain hypersensitivity in CLBP patients on the hand and on the painful site of the back...
  49. ncbi Pergolide increases the efficacy of cathodal direct current stimulation to reduce the amplitude of laser-evoked potentials in humans
    Daniella Terney
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    J Pain Symptom Manage 36:79-91. 2008
    ..Furthermore, it demonstrates the potential for repetitive daily stimulation therapy for pain patients...
  50. pmc Reliability of temporal summation and diffuse noxious inhibitory control
    S Cathcart
    University of South Australia, Adelaide, Australia
    Pain Res Manag 14:433-8. 2009
    ..Such devices may offer a simpler method than current techniques for inducing TS and DNIC, affording assessment at more anatomical locations and in more varied research settings...
  51. ncbi Could chronic pain and spread of pain sensation be induced and maintained by glial activation?
    E Hansson
    Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Acta Physiol (Oxf) 187:321-7. 2006
    ..This paper reviews current knowledge about glial mechanisms underlying the phenomena of chronic pain and spread of the pain sensation...
  52. ncbi Alone but feeling no pain: Effects of social exclusion on physical pain tolerance and pain threshold, affective forecasting, and interpersonal empathy
    C Nathan DeWall
    Department of Psychology, Florida State University, Tallahassee, FL 32306 1270, USA
    J Pers Soc Psychol 91:1-15. 2006
    ..The insensitivities to pain and emotion were highly intercorrelated...
  53. ncbi Pain and post traumatic stress disorder - review of clinical and experimental evidence
    Tobias Moeller-Bertram
    University of California San Diego, La Jolla, CA 92037, USA
    Neuropharmacology 62:586-97. 2012
    ..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
  54. ncbi Age-related differences in pain sensitivity and regional brain activity evoked by noxious pressure
    Leonie J Cole
    Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    Neurobiol Aging 31:494-503. 2010
    ..The age-related difference in pain-evoked activity seen in the present study may reflect reduced functioning of striatal pain modulatory mechanisms with advancing age...
  55. ncbi Botulinum neurotoxin type A (BoNTA) decreases the mechanical sensitivity of nociceptors and inhibits neurogenic vasodilation in a craniofacial muscle targeted for migraine prophylaxis
    Parisa Gazerani
    The Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada
    Pain 151:606-16. 2010
    ....
  56. ncbi Determinants of thermal pain thresholds in normal subjects
    Gunnar L Wasner
    Department of Neurology, Division of Neurological Pain Research and Therapy, University Clinic of Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany
    Clin Neurophysiol 119:2389-95. 2008
    ..This study sought to reduce inter-individual variations, investigated the reproducibility of measurements of thermal pain thresholds and included evaluation of thermally induced perceptions...
  57. ncbi Analysis of hyperalgesia time courses in humans after painful electrical high-frequency stimulation identifies a possible transition from early to late LTP-like pain plasticity
    Doreen B Pfau
    Department of Neurophysiology, Center of Biomedicine and Medical Technology Mannheim CBTM, Medical Faculty Mannheim, Ruprecht Karls University Heidelberg, Ludolf Krehl Str 13 17, 68167 Mannheim, Germany
    Pain 152:1532-9. 2011
    ..These findings support the hypothesis that LTP may contribute to the development of persistent pain disorders...
  58. pmc Activation of the prostaglandin system in response to sleep loss in healthy humans: potential mediator of increased spontaneous pain
    Monika Haack
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Pain 145:136-41. 2009
    ..Activation of the PGE2 system appears to be a potential mediator of increased spontaneous pain in response to insufficient sleep...
  59. ncbi Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain
    Sameer Sharma
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Eur J Pharmacol 536:256-61. 2006
    ..These results indicate an antinociceptive activity of curcumin possibly through its inhibitory action on NO and TNF-alpha release and point towards its potential to attenuate diabetic neuropathic pain...
  60. pmc Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice
    S K Segall
    Curriculum of Genetics and Molecular Biology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
    Genes Brain Behav 9:933-46. 2010
    ..SINE mice also exhibit behavioral differences in anxiety assays and decreased pain sensitivity. These results suggest that a haplotype, defined by a 3'-UTR B2 SINE element, regulates Comt1 expression and some mouse behaviors...
  61. ncbi Modulatory effects of anodal transcranial direct current stimulation on perception and pain thresholds in healthy volunteers
    P S Boggio
    Berenson Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Eur J Neurol 15:1124-30. 2008
    ..We aimed to evaluate whether transcranial direct current stimulation (tDCS) is effective in modulating sensory and pain perception thresholds in healthy subjects as to further explore mechanisms of tDCS in pain relief...
  62. pmc Central sensitization: a generator of pain hypersensitivity by central neural plasticity
    Alban Latremoliere
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    J Pain 10:895-926. 2009
    ..Instead, central sensitization produces pain hypersensitivity by changing the sensory response elicited by normal inputs, including those that usually evoke innocuous sensations...
  63. ncbi Cluster analysis of multiple experimental pain modalities
    Barbara A Hastie
    University of Florida College of Dentistry, Division of Public Health Services and Research, 1600 SW Archer Road, HSC D8 37, P O Box 100404, Gainesville, FL 32610 0404, USA
    Pain 116:227-37. 2005
    ..These findings highlight the need for future investigation to identify patterns of responses across different pain modalities in order to more accurately characterize individual differences in responses to experimental pain...
  64. pmc A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Eur J Pharmacol 569:48-58. 2007
    ..In conclusion, nitrosative stress plays an important role in sensory neuropathy associated with Type 1 diabetes. The findings provide rationale for further studies of peroxynitrite decomposition catalysts in a long-term diabetic model...
  65. pmc Effect of the combined use of tramadol and milnacipran on pain threshold in an animal model of fibromyalgia
    Seong Ho Kim
    Department of Internal Medicine, Dongguk University College of Medicine, Gyeongju, Korea
    Korean J Intern Med 24:139-42. 2009
    Acidic saline injections produce mechanical hyperresponsiveness in male Sprague-Dawley rats. We investigated the effect of milnacipran in conjunction with tramadol on the pain threshold in an acidic saline animal model of pain.
  66. ncbi Exploration of somatosensory impairments in subjects with mechanical idiopathic neck pain: a preliminary study
    Khodabakhsh Javanshir
    Physiotherapy Department, University of Social Welfare and Rehabilitation Sciences, Kodakyar St, Evin, Tehran, Iran
    J Manipulative Physiol Ther 33:493-9. 2010
    ..The purpose of this study was to investigate the differences in pressure and thermal pain hypersensitivity between patients with acute and chronic neck pain and healthy subjects...
  67. ncbi Extracephalic tenderness and pressure pain threshold in children with headache
    Liisa Metsahonkala
    Department of Child Neurology, Helsinki University Hospital, Helsinki, Finland
    Eur J Pain 10:581-5. 2006
    ..Children with migraine or with unspecific headache report non-headache pains and interictal pericranial muscular tenderness more often than headache-free children...
  68. ncbi Abnormal modulatory influence of diffuse noxious inhibitory controls in migraine and chronic tension-type headache patients
    G Sandrini
    University Centre for Adaptive Disorders and Headache, IRCCS C Mondino Foundation, University of Pavia, Pavia, Italy
    Cephalalgia 26:782-9. 2006
    ..Impairment of endogenous supraspinal pain modulation systems may contribute to the development and/or maintenance of central sensitization in primary headaches...
  69. ncbi The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain
    S Abdi
    Department of Anesthesiology and Critical Care, The Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Anesth Analg 87:1360-6. 1998
    ..Finally, the site of action of LDC seems to be primarily in the periphery, and that of GBP is exclusively central, whereas that of AMI seems to have both peripheral and central components...
  70. ncbi Neuropathic pain behaviours in a chronic-relapsing model of experimental autoimmune encephalomyelitis (EAE)
    Camille J Olechowski
    Centre for Neuroscience, University of Alberta, Edmonton, Alta, Canada
    Pain 141:156-64. 2009
    ..Taken together, our results show that the MOG(35-55) EAE model is a useful tool to study neuropathic pain in MS...
  71. pmc Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures
    Alexandra Doehring
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Goethe University, Frankfurt am Main, Germany
    PLoS ONE 6:e17724. 2011
    ..Such a measure would ease comparison of the magnitude of the effects across studies, for example the effect of gender on heat pain with the effect of a genetic variant on pressure pain...
  72. ncbi Cytotoxic targeting of isolectin IB4-binding sensory neurons
    L Vulchanova
    Department of Neuroscience, University of Minnesota, Minneapolis 55455, USA
    Neuroscience 108:143-55. 2001
    ....
  73. ncbi Use of a novel thermal operant behavioral assay for characterization of orofacial pain sensitivity
    John K Neubert
    Department of Orthodontics, College of Dentistry, University of Florida, 1600 SW Archer Road, P O Box 100444, Gainesville, FL 32610 0444, USA
    Pain 116:386-95. 2005
    ..These data reflect an orofacial pain behavior profile that was based on an animal's responses in an operant escape paradigm. This technique allows evaluation of nociceptive processing and modulation throughout the neuraxis...
  74. ncbi Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8
    Josephine Lai
    Department of Pharmacology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Pain 95:143-52. 2002
    ..These data provide direct evidence linking NaV1.8 to neuropathic pain. As NaV1.8 expression is restricted to sensory neurons, this channel offers a highly specific and effective molecular target for the treatment of neuropathic pain...
  75. ncbi Increased nerve growth factor after rat plantar incision contributes to guarding behavior and heat hyperalgesia
    Ratan K Banik
    Department of Anesthesia, 3000 ML, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Pain 117:68-76. 2005
    ..NGF contributes to some incision-induced pain behaviors, guarding and heat hyperalgesia. Anti-NGF did not affect the extent of sensitization of C-fibers observed in vitro...
  76. ncbi Effects of diffuse noxious inhibitory controls on temporal summation of the RIII reflex in humans
    Mariano Serrao
    Department of Neurology and Otolaryngology, University of Rome La Sapienza, Italy
    Pain 112:353-60. 2004
    ....
  77. ncbi Sleep deprivation affects thermal pain thresholds but not somatosensory thresholds in healthy volunteers
    Bernd Kundermann
    Department of Psychiatry and Psychotherapy, Philipps University Marburg, Rudolf Bultmann Str 8, Marburg D 35033, Germany
    Psychosom Med 66:932-7. 2004
    ..Thermal detection thresholds (warmth, cold) were included as covariates to determine the contribution of somatosensory functions to changes in pain processing...
  78. pmc Priming of adult pain responses by neonatal pain experience: maintenance by central neuroimmune activity
    Simon Beggs
    Portex Unit Pain Research, UCL Institute of Child Health and Great Ormond St Hospital NHS Trust, 30 Guilford St, London WC1N 1EH, UK
    Brain 135:404-17. 2012
    ..These data suggest that early life injury may predispose individuals to enhanced sensitivity to painful events...
  79. ncbi Affective modulation of brain potentials to painful and nonpainful stimuli
    Ramona Kenntner-Mabiala
    Department of Psychology, University of Wuerzburg, Wuerzburg, Germany
    Psychophysiology 42:559-67. 2005
    ..N150 amplitudes varying with picture valence seem to reflect an affective modulation of pain perception whereas P260 amplitudes varying with picture arousal rather reflect non-pain-specific attentional processes...
  80. ncbi Ultraviolet-B induced inflammation of human skin: characterisation and comparison with traditional models of hyperalgesia
    Thomas Bishop
    Neurorestoration Group, The Wolfson Centre for Age Related Disease, King s College London, The Wolfson Wing, Hodgkin Building, Guy s Campus, London Bridge, London SE11UL, United Kingdom
    Eur J Pain 13:524-32. 2009
    ..Moreover, UVB inflammation induced large reductions in mechanical pain threshold restricted to the primary lesion site, whereas the more established inflammatory pain models produced not only ..
  81. ncbi Gender differences in pain modulation by diffuse noxious inhibitory controls: a systematic review
    Adriana Popescu
    Department of Oral Medicine, University of Washington, Seattle, WA 98195 6370, USA
    Pain 150:309-18. 2010
    ..Gender differences in DNIC effect depend on both the experimental methodology and the modes of measurement of the effect...
  82. ncbi Hyperalgesia in a human model of acute inflammatory pain: a methodological study
    J L Pedersen
    Department of Surgical Gastroenterology, Hvidovre University Hospital, Denmark
    Pain 74:139-51. 1998
    ..In similar models, we recommend that analgesic and placebo are evenly divided between right and left sides and study days...
  83. ncbi Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury
    Ji Zhang
    Unite de Neurobiologie Cellulaire, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec, Canada
    J Neurochem 97:772-83. 2006
    ..Delayed, sustained astrocyte activation may participate with microglia in the persistent phase of pain hypersensitivity...
  84. ncbi Altered cerebral response to noxious heat stimulation in patients with somatoform pain disorder
    H Gundel
    Abteilung Psychosomatik und Psychotherapie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Pain 137:413-21. 2008
    ..Our findings of an altered cerebral processing of experimentally induced pain in patients with somatoform pain disorder support the hypothesis of dysfunctional pain processing, especially in affect regulating regions...
  85. ncbi Biochemical alterations in the trapezius muscle of patients with chronic whiplash associated disorders (WAD)--a microdialysis study
    Björn Gerdle
    Division of Rehabilitation Medicine, Department of Neuroscience and Locomotion, Faculty of Health Sciences, SE 58185 Linkoping, Sweden
    Eur J Pain 12:82-93. 2008
    ....
  86. ncbi Hyper-responsivity in a subset of C-fiber nociceptors in a model of painful diabetic neuropathy in the rat
    X Chen
    Departments of Anatomy, Medicine, and Oral and Maxillofacial Surgery, Division of Neuroscience, NIH Pain Center (UCSF, University of California, San Francisco 94143-0440, USA
    Neuroscience 102:185-92. 2001
    ..The present findings suggest that study of individual neurons in vitro may allow elucidation of the ionic basis of enhanced nociception in diabetic neuropathy...
  87. ncbi Elevated pain thresholds correlate with dissociation and aversive arousal in patients with borderline personality disorder
    Petra Ludäscher
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Psychiatry Res 149:291-6. 2007
    ..Measuring electric pain thresholds is a valid and reasonable method for larger studies...
  88. ncbi Depression and changed pain perception: hints for a central disinhibition mechanism
    Sabrina Klauenberg
    Department of Pain Management, Berufsgenossenschaftliche Universitätsklinik Bergmannsheil GmbH, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Pain 140:332-43. 2008
    ..g. by inhibited serotonergic function. Furthermore, this trial demonstrates the feasibility of QST in depressive patients...
  89. ncbi C-nociceptors sensitized to cold in a patient with small-fiber neuropathy and cold allodynia
    Jordi Serra
    Department of Neurology, MC Mutual, Barcelona, Spain
    Pain 147:46-53. 2009
    ..The responsiveness of C-nociceptors to menthol suggests an abnormal expression or function of TRPM8 channels in this patient with a small-fiber polyneuropathy...
  90. ncbi The deficit of pain inhibition in fibromyalgia is more pronounced in patients with comorbid depressive symptoms
    Juliana Barcellos de Souza
    Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Canada
    Clin J Pain 25:123-7. 2009
    ..We hypothesized that the deficit in pain inhibition would be more pronounced in FM patients with depressive symptoms (FM+D), relative to patients without such symptoms (FM-D)...
  91. ncbi Clinical and pre-clinical pain assessment: are we measuring the same thing?
    C J Vierck
    Department of Neuroscience, College of Medicine, Comprehensive Center for Pain Research, University of Florida, 200 Newell Drive, McKnight Brain Institute, Gainesville, FL, USA
    Pain 135:7-10. 2008
  92. ncbi Altered pain processing in veterans with posttraumatic stress disorder
    Elbert Geuze
    Department of Military Psychiatry, Central Military Hospital, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arch Gen Psychiatry 64:76-85. 2007
    ..Several brain areas related to pain processing are implicated in PTSD. To our knowledge, no functional imaging study has discussed whether patients with PTSD experience and process pain in a different way than control subjects...
  93. ncbi Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats
    Marc André Dansereau
    Department of Physiology and Biophysics, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada
    J Neurochem 106:757-69. 2008
    ..Therefore, preventing the activation of CCR2 might provide a fruitful strategy for treating pain...
  94. ncbi Experimental lumbar radiculopathy. Immunohistochemical and quantitative demonstrations of pain induced by lumbar nerve root irritation of the rat
    M Kawakami
    Department of Orthopedic Surgery, Wakayama Medical College, Japan
    Spine (Phila Pa 1976) 19:1780-94. 1994
    ..abstract truncated at 400 words)..
  95. ncbi Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy
    B Shim
    Brain Research Institute, Brain Korea 21 Project for Medical Science, and Department of Physiology, Yonsei University College of Medicine, C P O Box 8044, 120 752, Seoul, South Korea
    Neuroscience 132:193-201. 2005
    ..This nociceptor sensitization can contribute to neuropathic pain...
  96. pmc Association of major depressive disorder with altered functional brain response during anticipation and processing of heat pain
    Irina A Strigo
    Department of Psychiatry, University of California San Diego, 3350 La Jolla Village Dr, Bldg 13, MC 9151 B, La Jolla, CA 92161, USA
    Arch Gen Psychiatry 65:1275-84. 2008
    ..Chronic pain and depression are highly comorbid conditions, yet little is known about the neurobiological basis of pain processing in major depressive disorder (MDD)...
  97. pmc Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158)met polymorphism
    Karin B Jensen
    Osher Center for Integrative Medicine, Stockholm Brain Institute, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 4:e6016. 2009
    ..g. chronic pain patients. This has to be proven in future studies where the impact of the COMTval(158)met polymorphism on opioid treatment in patients is addressed...
  98. ncbi Assessing mechanical allodynia in the rat paw with a new electronic algometer
    K A Moller
    In Vivo Pharmacology, Discovery Unit, Astra Pain Control AB, Novum, Huddinge, Sweden
    J Neurosci Methods 84:41-7. 1998
    ..In conclusion, the electronic algometer allows standardization of testing, detailed documentation of each experiment and provides an objective and accurate method for measuring the reactions of test animals to mechanical stimuli...
  99. ncbi Somatosensory profiles in subgroups of patients with myogenic temporomandibular disorders and Fibromyalgia Syndrome
    Doreen B Pfau
    Department of Neurophysiology, Center of Biomedicine and Medical Technology Mannheim, Ruprecht Karls University Heidelberg, Mannheim, Germany
    Pain 147:72-83. 2009
    ..g. a disturbance of central pain processing, in this subgroup of TMD patients. Those patients could be identified on the basis of their tender point count as an easy practicable screening tool...
  100. pmc Defining the nociceptive flexion reflex (NFR) threshold in human participants: a comparison of different scoring criteria
    Jamie L Rhudy
    Department of Psychology, University of Tulsa, OK, USA
    Pain 128:244-53. 2007
    ....
  101. pmc Genetic predictors for acute experimental cold and heat pain sensitivity in humans
    H Kim
    J Med Genet 43:e40. 2006
    ..The genetic contribution to pain sensitivity underlies a complex composite of parallel pain pathways, multiple mechanisms, and diverse inter-individual pain experiences and expectations...

Research Grants63

  1. Medical Management of Pediatric Neurotransmitter Disorders- A Multidisciplinary
    K Michael Gibson; Fiscal Year: 2007
    ..epinephrine, serotonin and GABA are critical in CNS activities that include regulation of body temperature and pain threshold, control of behavior and motor function, neuronal excitation and inhibition, memory, and many other body ..
  2. Pathophysiology and Animal Model of Restless Legs Syndrome (RLS): Btbd9 Null Mic
    Yuqing Li; Fiscal Year: 2010
    ..4. To test the hypothesis that BTBD9 mutation affects sensory system, we will measure the pain threshold using tail flick and hot plate assays, and sense of touch using Von Frey fibers...
  3. Cyclosporine in Interstitial Cystitis: Efficacy, Safety and Mechanism of Action
    Daniel Shoskes; Fiscal Year: 2013
    ..We will then measure the effects of cyclosporine treatment on current perception and pain threshold using a Neurometer before, during and after treatment...
  4. Effects of aging on primary afferent function
    RATAN BANIK; Fiscal Year: 2009
    ..and their ability to respond to mechanical, heat and cold stimuli;and 3) determine age- related changes in the pain threshold related behaviors...
  5. Mechanisms of Hypovitaminosis D Pain: Role of Nociceptor Sprouting.
    SARAH ELIZABETH TAGUE; Fiscal Year: 2010
    ..of this project is that a vitamin D deficiency leads to nociceptor hyperinnervation of tissue, altering pain threshold. Understanding whether vitamin D directly affects peripheral neurons will enable physicians to orchestrate ..
  6. Central Sensitization in Post-Knee Replacement Pain and Relation to OA Pathology
    Tuhina Neogi; Fiscal Year: 2013
    ..Two measures of central sensitization will be evaluated: 1) temporal summation and 2) pressure pain threshold, which is a marker of peripheral and/or central sensitization at sites of disease, or of central sensitization ..
  7. Analgesic Mechanism of Action of Endogenous Opioid Peptides Enkephalins with a Fo
    Gregory Scherrer; Fiscal Year: 2011
    ..we will use behavioral assays to test the hypothesis that enkephalinergic neurons are critical to setting pain threshold during chronic pain...
  8. Analgesic Mechanism of Action of Endogenous Opioid Peptides Enkephalins with a Fo
    Gregory Scherrer; Fiscal Year: 2013
    ..we will use behavioral assays to test the hypothesis that enkephalinergic neurons are critical to setting pain threshold during chronic pain...
  9. Native American Pain Disparities: Exploring Nociceptive Processing Differences
    JAMIE LYNN RHUDY; Fiscal Year: 2013
    ..Pain sensitivity will be comprehensively assessed from pain threshold, tolerance, and report in response to multiple stimulus modalities (heat, cold, mechanical pressure, ischemia, ..
  10. The Prefrontal Cortex in Neuropathic pain
    Marco Martina; Fiscal Year: 2012
    ..Interestingly, several of these changes are correlated with the pain threshold in the injured paw...
  11. Optimizing Pain Treatment while Reducing Abuse Liability in Opioid Dependence
    David Andrew Tompkins; Fiscal Year: 2013
    ..will utilize a double-blind placebo controlled design to measure the analgesic (change in experimental pain threshold and tolerance), subjective, and objective drug effects provided by intravenous doses of hydromorphone and ..
  12. Ligands that target opioid-chemokine and opioid-mGlu5 heteromers
    Philip S Portoghese; Fiscal Year: 2013
    ..inflammatory state is responsible for promoting increased levels of glutamate that leads to a lowering of the pain threshold. In this regard, the use of morphine, either with a chemokine receptor antagonist or a metabotropic glutamate-..
  13. Hypogonadism and Pain Perception in Androgen-Deprived Men with Prostate Cancer
    Robert R Edwards; Fiscal Year: 2013
    ..and 2) We will assess the associations of various metabolic and inflammatory markers with pain perception and pain threshold in men undergoing ADT...
  14. Pain Mechanisms and Outcomes in Osteoarthritis
    Kristine Phillips; Fiscal Year: 2013
    ..patients with osteoarthritis, as well as provide a more detailed understanding of etiologic relationships of pain threshold and affective disorders on chronic osteoarthritis pain and outcomes following joint replacement...
  15. Novel Use of Ketotifen (Mast Cell Stablizier)in Fibromyalgia: A Pilot Study
    DENNIS CHUA ANG; Fiscal Year: 2012
    ..e., IL-8, MCP-1 and eotaxin) and pressure pain threshold. The proposed research is innovative because it will be the first to investigate the effects of an immune-..
  16. Effects of Smoking Abstinence on Pain Reactivity: A Human Experimental Model
    Joseph W Ditre; Fiscal Year: 2012
    ..Specifically, we hypothesize that smokers randomized to the SA condition will report lower pain threshold, greater pain intensity, and greater pain unpleasantness during experimental pain induction than smokers ..
  17. Chemokine Signaling in Diabetic Neuropathy
    Daniela M Menichella; Fiscal Year: 2013
    ..Neuropathic pain is caused by sustained excitability in sensory neurons which reduces the pain threshold, so that pain is produced in the absence of appropriate stimuli...
  18. OPIOID-INDUCED PAIN SENSITIVITY: CLINICAL DIAGNOSIS AND MANAGEMENT
    Jianren Mao; Fiscal Year: 2010
    ..be assessed clinically through descriptive and quantitative pain assessment tools such as measuring changes in pain threshold and identifying abnormal clinical pain characteristics? 2) Do various types and doses of opioids play a ..
  19. CHARACTERIZATION OF PLACENTAL OPIOID-ENHANCING FACTOR
    MARK KRISTAL; Fiscal Year: 1991
    ..Using tail-flick latency in rats as a behavioral measure of pain threshold, the presence and potency of POEF in various fractions of rat placenta and amniotic fluid will be determined ..
  20. VERY LOW ENERGY CARDIOVERSION FOR ATRIAL FIBRILLATION
    Patrick Wolf; Fiscal Year: 2003
    ..The applied shock strength of 3-10 Joules is above a patient's pain threshold and this limits the broad application of IAD therapy...
  21. ELDER PAIN--ASSESSMENT OF INTENSITY
    Keela Herr; Fiscal Year: 1999
    ..b>Pain threshold will be determined at the beginning of the session to be used in establishing validity of responses to each ..
  22. ERBIUM YAG LASER DRILL FOR DENTISTRY
    ABID PAGHDIWALA; Fiscal Year: 1990
    ..And, as the duration of the erbium laser pulses used is in the microsecond range, well below the pain threshold of the brain, laser drilling of teeth may be almost painless...
  23. MUSCULOSKELETAL DISORDER IN AUTOMOBILE MANUFACTURING
    Laura Punnett; Fiscal Year: 2002
    ..by standardized interview, screening physical examination, grip and pinch strength, vibrometry, and pressure pain threshold testing...
  24. FOREBRAIN MECHANISMS IN CHRONIC NON-NEUROPATHIC PAIN
    Kenneth Casey; Fiscal Year: 2002
    ..from peak rCBF increases within the above structures in response to heat stimuli applied at 35EC, heat pain threshold (HPT), heat pain tolerance (Hptol), and at 3 additional intensities anchored symmetrically around HPT and ..
  25. ACC Sensitization in Visceral Hypersensitive Rats
    Chung Owyang; Fiscal Year: 2010
    ..This heightened synaptic transmission leads to a reduction in pain threshold and an amplification of affective responses to pain...
  26. Assessment of the Dopamine System in Fibromyalgia
    KARMEN YODER; Fiscal Year: 2009
    ..Subjects will also undergo pressure/pain threshold testing...
  27. Maternal Separation: Rat Model of Opioid Vulnerability
    STEPHEN HOLTZMAN; Fiscal Year: 2006
    ..They also have altered sensitivity to effects of acute and chronic morphine on pain threshold and motor activity...
  28. BEHAVIORAL PHARMACOLOGY OF NARCOTIC ANTAGONISTS
    STEPHEN HOLTZMAN; Fiscal Year: 2002
    ..d) Tail-flick test: a measure of pain threshold. Compared to chronic opioid dependence, acute dependence has received little research attention despite the ..
  29. OPIATE-CATECHOLAMINE RECEPTOR INTERACTIONS IN NEURONS
    DAVID U PRICHARD; Fiscal Year: 1980
    ..Conversely, patients on alpha2-antihypertensive therapy may experience altered pain threshold and narcotic analgesic efficacy...
  30. Symposium on Pediatric Neurotransmitter Disease
    K Michael Gibson; Fiscal Year: 2002
    ..norepinephrine, serotonin and GABA are critical in CNS activities including regulation of body temperature and pain threshold, control of behavior and motor function, neuronal excitation and inhibition, memory, and a host of other ..
  31. MECHANISMS UNDERLYING MATERNAL CALMING AND ANALGESIA
    ELLIOTT BLASS; Fiscal Year: 1993
    ..Alterations in odor preference, in levels of vocalization during isolation and in pain threshold will be determined in the presence of the associated odor...
  32. PSYCHOPHYSIOLOGICAL INTERACTIONS--NON-CARDIAC CHEST PAIN
    LAURENCE BRADLEY; Fiscal Year: 2001
    ..e., pain threshold and response bias levels)...
  33. The Efficacy of Reiki in the Treatment of Fibromyalgia & CFS
    Dedra Buchwald; Fiscal Year: 2003
    ..Secondary outcomes will include pain threshold, sleep, fatigue, and psychological indicators...
  34. Lifestyle Physical Activity for Fibromyalgia
    Kevin Fontaine; Fiscal Year: 2009
    ..Evaluating the effects of LPA on pain threshold, metabolic efficiency/perceived exertion, sleep parameters, and pain catastrophizing will provide mechanistic ..
  35. GENDER DIFFERENCES IN PAIN RESPONSES OF THE ELDERLY.
    Anna Ratka; Fiscal Year: 1999
    ..Research efforts will focus on three specific aims. Aim 1: Characterize dynamic changes in pain threshold, pain tolerance, pain intensity, and pain relief in elderly women and men...
  36. Analgesia Induced by Athletic Competition
    WENDY STERNBERG; Fiscal Year: 2001
    ..in male and female subjects: determine the lone-term and short-term time course of the analgesic effects of stressful whether individual differences in pain threshold and/or tolerance contribute to athletic statu.
  37. K-OPIOID SYSTEMS--SEX AND PREGNANCY LINKED DIFFERENCES
    CARRIE DRAKE; Fiscal Year: 2002
    ..Second, the well-documented increase in pain threshold during late pregnancy, i.e...
  38. PATHOGENESIS OF TMD MYALGIA SYMPTOMS
    Christian Stohler; Fiscal Year: 2001
    ..masticatory myalgia influences the low-threshold mechanosensitivity of the facial skin, or the pressure-pain threshold of facial tissues...
  39. EFFECTS OF AN ERGONOMIC INTERVENTION FOR COMPUTER WORK
    David Rempel; Fiscal Year: 2002
    ..If a predetermined pain threshold is exceeded then a physical examination will be performed to determine whether or not a musculoskeletal ..
  40. PAIN MANAGEMENT IN ALCOHOLICS
    Louis Fiset; Fiscal Year: 1993
    ..Controls will be matched on age and race. Intra- and inter-group comparisons will be made following electrical tooth stimulation at pain stimulus detection, pain threshold, and pain tolerance.
  41. OPIATES AND PERIPHERAL ANTINOCICEPTION
    Gordon Barr; Fiscal Year: 1999
    ..to study, in a rat model, the development of the inflammatory process with special attention to its effects on pain threshold; the development of opiate induced antinociception in inflamed and non-inflamed tissue; and upregulation of ..
  42. CARDIAC SENSORY INTEGRATION IN CERVICAL SPINAL CORD
    Robert Foreman; Fiscal Year: 1999
    ..Thus, these results are expected to provide a neurophysiological basis to explain the elevated pain threshold that is observed in patients who experience myocardial ischemia without pain and are at risk for sudden death.
  43. Anger Expression, Opioid Dysfunction, and Chronic Pain
    Stephen Bruehl; Fiscal Year: 2009
    ....
  44. PAIN REGULATORY SYSTEM DYSFUNCTION IN CHRONIC PAIN
    Stephen Bruehl; Fiscal Year: 2002
    ..Greater pain duration is expected to be associated with smaller changes in the BP/pain relationship in response to opioid blockade. ..
  45. Pain Regulatory Dysfunction in Chronic Pain
    Stephen Bruehl; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  46. Peripheral and Central Mechanism of Pain in Patients with Fibromyalgia
    ROLAND M STAUD; Fiscal Year: 2010
    ..Either way, we will provide evidence that will characterize the role of local anesthesia, placebo analgesia, or both. Thus patients with FM and other similar pain syndromes may strongly benefit from the results of our study. ..
  47. MECHANISM OF PAIN IN PATIENTS WITH FIBROMYALGIA SYNDROME
    Roland Staud; Fiscal Year: 2008
    ..is a symptom based diagnosis that depends on the presence of chronic widespread pain and decreased mechanical pain threshold at >= 11 well defined tender points...
  48. GENDER, COPING AND THE ARTHRITIS PAIN EXPERIENCE
    Francis Keefe; Fiscal Year: 2002
    ..Study 2 will assess the NFR threshold and subjective pain threshold and tolerance levels of 66 men and 66 women having OA knee pain...
  49. NEUROBIOLOGY OF CHRONIC MUSCLE PAIN
    Kathleen Sluka; Fiscal Year: 2003
    ..These proposed studies will help in the understanding and thus potential treatment of chronic muscle pain, including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  50. Neurobiology of Joint Manipulation Induced Analgesia
    Kathleen Sluka; Fiscal Year: 2003
    ..This information will further assist the clinician in determining the treatment of choice for a particular patient and potentially guide future clinical research. ..
  51. Central contributions to pathobiology of fibromyalgia
    Kathleen Sluka; Fiscal Year: 2009
    ..A better understanding of the pathobiological mechanisms underlying musculoskeletal pain conditions may lead to the development of novel therapeutic approaches for its treatment. ..
  52. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen A Sluka; Fiscal Year: 2010
    ..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..
  53. APS Travel Award
    Kathleen Sluka; Fiscal Year: 2007
    ..C. These funds will allow trainees to attend and interact with both clinicians and researchers from multiple disciplines including medicine, nursing, psychology, and physical therapy. [unreadable] [unreadable] [unreadable]..
  54. Individual Differences in Pain Modulation as Predictors of Post-Surgical Pain
    Robert Edwards; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  55. Catastrophizing and Pain in Rheumatoid Arthritis
    Robert Edwards; Fiscal Year: 2008
    ..abstract_text> ..
  56. Neurobiology of Musculoskeletal Pain
    Kathleen Sluka; Fiscal Year: 2005
    ..These proposed studies are intended to help in the understanding and thus potential treatment of chronic muscle pain including such conditions as fibromyalgia, myofascial pain and low back pain. ..
  57. Virtual Reality and Acute Pain Management for Children
    Lynnda Dahlquist; Fiscal Year: 2007
    ..In both studies, children are expected to demonstrate improvements in pain tolerance, pain threshold, and perceived pain intensity during the distraction conditions...
  58. HYPERTENSION, RISK FOR HYPERTENSION AND HYPOALGESIA
    Christopher France; Fiscal Year: 2003
    ..This information could be used to identify the best candidates for behavioral and other risk reduction efforts. ..
  59. Hyperalgesia in Methadone Patients: Can it be Treated?
    Margaret Compton; Fiscal Year: 2007
    ..ability to ameliorate or diminish the opioid-induced hyperalgesia in these patients as reflected by changes on pain threshold and tolerance to both cold-pressor and electrical pain, at peak and through methadone blood levels...
  60. Preventing Adverse Reactions in Novice Blood Donors
    Christopher R France; Fiscal Year: 2010
    ..Because we are working directly with the American Red Cross, our findings can be quickly translated into practice. ..
  61. Sleep Disturbance and Pain Sensitivity in Chronic Pain
    Michael Smith; Fiscal Year: 2008
    ..the diagnosis of insomnia and/or sleep microstructure abnormalities are associated with decreased pressure pain threshold, and 3) determine whether measures of sleep predict the short-term (2-month) course of pain severity...
  62. Rehabilitation of Spinal Cord Injury-Related Pain
    Mark Jensen; Fiscal Year: 2006
    ..abstract_text> ..