sciatica

Summary

Summary: A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of SCIATIC NEUROPATHY; RADICULOPATHY (involving the SPINAL NERVE ROOTS; L4, L5, S1, or S2, often associated with INTERVERTEBRAL DISK DISPLACEMENT); or lesions of the CAUDA EQUINA.

Top Publications

  1. ncbi Piriformis muscle: clinical anatomy and consideration of the piriformis syndrome
    Gunther Windisch
    Institute of Anatomy, Medical University Graz, Harrachgasse 21, 8010, Graz, Austria
    Surg Radiol Anat 29:37-45. 2007
  2. ncbi Recovery of severe sciatica
    F Balague
    Hopital Cantonal, Fribourg, Switzerland
    Spine (Phila Pa 1976) 24:2516-24. 1999
  3. ncbi Surgery versus prolonged conservative treatment for sciatica
    Wilco C Peul
    Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands
    N Engl J Med 356:2245-56. 2007
  4. ncbi Periradicular infiltration for sciatica: a randomized controlled trial
    J Karppinen
    Department of Physical Medicine and Rehabilitation, University Hospital of Oulu, Finland
    Spine (Phila Pa 1976) 26:1059-67. 2001
  5. pmc Physicians' initial management of acute low back pain versus evidence-based guidelines. Influence of sciatica
    Barbara S Webster
    Center for Disability Research, Liberty Mutual Research Institute for Safety, Hopkinton, MA 01748, USA
    J Gen Intern Med 20:1132-5. 2005
  6. pmc Surgery versus conservative management of sciatica due to a lumbar herniated disc: a systematic review
    Wilco C H Jacobs
    Department of Neurosurgery, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur Spine J 20:513-22. 2011
  7. ncbi Sciatica
    Jean Pierre Valat
    Rhumatologie, Universite Francois Rabelais, Faculte de Medecine de Tours, Tours Cedex, 10 boulevard Tonnelle, BP 3223, 37032 Tours Cedex, France
    Best Pract Res Clin Rheumatol 24:241-52. 2010
  8. ncbi [How neuropathic is sciatica? The mixed pain concept]
    R Baron
    Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel
    Orthopade 33:568-75. 2004
  9. ncbi Magnetic resonance imaging in follow-up assessment of sciatica
    Abdelilah El Barzouhi
    Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands
    N Engl J Med 368:999-1007. 2013
  10. ncbi Assessing health-related quality of life in patients with sciatica
    D L Patrick
    Department of Health Services, University of Washington, Seattle, Washington, USA
    Spine (Phila Pa 1976) 20:1899-908; discussion 1909. 1995

Detail Information

Publications311 found, 100 shown here

  1. ncbi Piriformis muscle: clinical anatomy and consideration of the piriformis syndrome
    Gunther Windisch
    Institute of Anatomy, Medical University Graz, Harrachgasse 21, 8010, Graz, Austria
    Surg Radiol Anat 29:37-45. 2007
    ..Based on this survey anatomical causes for the piriformis syndrome are rare and a more precise workup is necessary to rule out more common diagnosis...
  2. ncbi Recovery of severe sciatica
    F Balague
    Hopital Cantonal, Fribourg, Switzerland
    Spine (Phila Pa 1976) 24:2516-24. 1999
    A prospective study of patients with acute severe sciatica.
  3. ncbi Surgery versus prolonged conservative treatment for sciatica
    Wilco C Peul
    Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands
    N Engl J Med 356:2245-56. 2007
    Lumbar-disk surgery often is performed in patients who have sciatica that does not resolve within 6 weeks, but the optimal timing of surgery is not known.
  4. ncbi Periradicular infiltration for sciatica: a randomized controlled trial
    J Karppinen
    Department of Physical Medicine and Rehabilitation, University Hospital of Oulu, Finland
    Spine (Phila Pa 1976) 26:1059-67. 2001
    ..A randomized, double-blind trial was conducted...
  5. pmc Physicians' initial management of acute low back pain versus evidence-based guidelines. Influence of sciatica
    Barbara S Webster
    Center for Disability Research, Liberty Mutual Research Institute for Safety, Hopkinton, MA 01748, USA
    J Gen Intern Med 20:1132-5. 2005
    ..Little information is available on physician characteristics and patient presentations that may influence compliance with evidence-based guidelines for acute low back pain...
  6. pmc Surgery versus conservative management of sciatica due to a lumbar herniated disc: a systematic review
    Wilco C H Jacobs
    Department of Neurosurgery, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur Spine J 20:513-22. 2011
    The effectiveness of surgery in patients with sciatica due to lumbar disc herniations is not without dispute...
  7. ncbi Sciatica
    Jean Pierre Valat
    Rhumatologie, Universite Francois Rabelais, Faculte de Medecine de Tours, Tours Cedex, 10 boulevard Tonnelle, BP 3223, 37032 Tours Cedex, France
    Best Pract Res Clin Rheumatol 24:241-52. 2010
    b>Sciatica is a symptom rather than a specific diagnosis. Available evidence from basic science and clinical research indicates that both inflammation and compression are important in order for the nerve root to be symptomatic...
  8. ncbi [How neuropathic is sciatica? The mixed pain concept]
    R Baron
    Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel
    Orthopade 33:568-75. 2004
    Different pathophysiological mechanisms are thought to operate in chronic sciatica. Nociceptive and neuropathic pain components can be distinguished...
  9. ncbi Magnetic resonance imaging in follow-up assessment of sciatica
    Abdelilah El Barzouhi
    Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands
    N Engl J Med 368:999-1007. 2013
    Magnetic resonance imaging (MRI) is frequently performed during follow-up in patients with known lumbar-disk herniation and persistent symptoms of sciatica. The association between findings on MRI and clinical outcome is controversial.
  10. ncbi Assessing health-related quality of life in patients with sciatica
    D L Patrick
    Department of Health Services, University of Washington, Seattle, Washington, USA
    Spine (Phila Pa 1976) 20:1899-908; discussion 1909. 1995
    ..OBJECTIVE. For persons with sciatica, back pain-specific and general measures of health-related quality-of-life were compared with regard to internal ..
  11. ncbi Serum lipids in relation to sciatica among Finns
    Päivi Leino-Arjas
    Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN 00250 Helsinki, Finland
    Atherosclerosis 197:43-9. 2008
    ..supplying the lumbar region has been suggested as a mechanism leading to intervertebral disc degeneration and sciatica. The study described here examined whether serum lipid levels or pharmacologically treated hyperlipidemia were ..
  12. ncbi Epidural corticosteroid injections in the management of sciatica: a systematic review and meta-analysis
    Rafael Zambelli Pinto
    The George Institute for Global Health, Sydney Medical School, University of Sydney, Sydney, Australia
    Ann Intern Med 157:865-77. 2012
    ..guidelines and systematic reviews provide inconsistent recommendations on epidural corticosteroid injections for sciatica. Key limitations of existing reviews are the inclusion of trials with active controls of unknown efficacy and ..
  13. pmc Epidural corticosteroid injections for sciatica: a randomised, double blind, controlled clinical trial
    J P Valat
    Service de Rhumatologie, Hopital Trousseau, CHU, Tours, France
    Ann Rheum Dis 62:639-43. 2003
    To determine the efficacy of epidural corticosteroid injections for sciatica.
  14. ncbi Sciatica: what the rheumatologist needs to know
    Maurits van Tulder
    Department of Health Sciences and EMGO Institute for Health and Care Research, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Nat Rev Rheumatol 6:139-45. 2010
    b>Sciatica is a set of symptoms rather than a specific diagnosis, and is caused by a herniated lumbar disc in the vast majority of cases. The most important symptom is lower limb pain radiating below the knee and into the foot and toes...
  15. ncbi Selective nerve root blocks for the treatment of sciatica: evaluation of injection site and effectiveness--a study with patients and cadavers
    C W Pfirrmann
    Department of Radiology, University Hospital Balgrist, Forchstrasse 340, Ch 8008 Zurich, Switzerland
    Radiology 221:704-11. 2001
    ..To relate different types of radiographic contrast material distributions to anatomic compartments by using cadaveric specimens and to relate the injection site to treatment-induced discomfort and therapeutic effect...
  16. pmc Prolonged conservative care versus early surgery in patients with sciatica caused by lumbar disc herniation: two year results of a randomised controlled trial
    Wilco C Peul
    Department of Neurosurgery, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, Netherlands
    BMJ 336:1355-8. 2008
    To evaluate the effects of early lumbar disc surgery compared with prolonged conservative care for patients with sciatica over two years of follow-up.
  17. ncbi The natural history of lumbar intervertebral disc extrusions treated nonoperatively
    J A Saal
    San Francisco Spine Institute, Seton Medical Center, Daly City, California 94015
    Spine (Phila Pa 1976) 15:683-6. 1990
    ..abstract truncated at 250 words)..
  18. pmc Surgical vs nonoperative treatment for lumbar disk herniation: the Spine Patient Outcomes Research Trial (SPORT) observational cohort
    James N Weinstein
    Dartmouth Medical School, Hanover, NH, USA
    JAMA 296:2451-9. 2006
    ..However, the large numbers of patients who crossed over between assigned groups precluded any conclusions about the comparative effectiveness of operative therapy vs usual care...
  19. pmc Predicting the outcome of sciatica at short-term follow-up
    Patrick C A J Vroomen
    Department of Clinical Neurophysiology, Maastricht University Hospital, The Netherlands
    Br J Gen Pract 52:119-23. 2002
    The prognostic value of the clinical findings elicited in the patient presenting with sciatica is unknown.
  20. ncbi Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide
    Marucia Chacur
    Instituto Butantan, Sao Paolo, Brazil
    Pain 108:180-91. 2004
    ..As a variety of immune cells also produce and release sPLA2s during inflammatory states, the data may have general implications for the understanding of inflammatory pain...
  21. pmc Drugs for relief of pain in patients with sciatica: systematic review and meta-analysis
    Rafael Zambelli Pinto
    George Institute For Global Health, University of Sydney, PO Box M201, Camperdown, Sydney, NSW 2050, Australia
    BMJ 344:e497. 2012
    To investigate the efficacy and tolerability of analgesic and adjuvant pain drugs typically administered in primary care for the management of patients with sciatica.
  22. pmc Efficacy of epidural administration of anti-interleukin-6 receptor antibody onto spinal nerve for treatment of sciatica
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    Eur Spine J 21:2079-84. 2012
    ..However, efficacy of inhibition of IL-6 for sciatica in patients with lumbar spinal stenosis has not been clarified...
  23. ncbi Is a condition-specific instrument for patients with low back pain/leg symptoms really necessary? The responsiveness of the Oswestry Disability Index, MODEMS, and the SF-36
    Thomas L Walsh
    The Spine Center at Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Spine (Phila Pa 1976) 28:607-15. 2003
    ..Analysis of longitudinal data collected prospectively from patients seen in 27 National Spine Network member centers across the United States...
  24. ncbi [Criteria validation of the Roland Morris questionnaire. A Danish translation of the international scale for the assessment of functional level in patients with low back pain and sciatica]
    Hanne B Albert
    Rygambulatoriet, Sygehus Fyn Ringe
    Ugeskr Laeger 165:1875-80. 2003
    ..Questionnaire (RMQ), which evaluates the functional level of activity of patients with low back pain and possible sciatica. The RMQ was compared with the functional scale of a Danish functional and pain level questionnaire, The Low Back ..
  25. pmc Prognostic factors for non-success in patients with sciatica and disc herniation
    Anne Julsrud Haugen
    Department of Rheumatology, Østfold Hospital Trust, Fredrikstad, Norway
    BMC Musculoskelet Disord 13:183. 2012
    Few studies have investigated prognostic factors for patients with sciatica, especially for patients treated without surgery...
  26. ncbi Epidural venous enlargements presenting with intractable lower back pain and sciatica in a patient with absence of the infrarenal inferior vena cava and bilateral deep venous thrombosis
    Oliver Dudeck
    Department of Radiology, Charite, Campus Buch, Berlin, Germany
    Spine (Phila Pa 1976) 32:E688-91. 2007
    ..Case report...
  27. ncbi Epidural steroids, etanercept, or saline in subacute sciatica: a multicenter, randomized trial
    Steven P Cohen
    Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Ann Intern Med 156:551-9. 2012
    ..Perineural inhibitors of tumor necrosis factor have recently generated intense interest as an alternative to epidural steroid injections for lumbosacral radiculopathy...
  28. ncbi Epidural administration of spinal nerves with the tumor necrosis factor-alpha inhibitor, etanercept, compared with dexamethasone for treatment of sciatica in patients with lumbar spinal stenosis: a prospective randomized study
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 37:439-44. 2012
    ..Prospective randomized trial...
  29. ncbi Comorbid subjective health complaints in patients with sciatica: a prospective study including comparison with the general population
    Lars Grøvle
    Department of Rheumatology, Østfold Hospital Trust, Fredrikstad, Norway
    J Psychosom Res 70:548-56. 2011
    ..The aims of this study were to investigate if patients with specific back pain, that is, sciatica caused by lumbar herniation, report higher rates of subjective health complaints (SHCs) than the general ..
  30. ncbi Factors predicting outcomes of mechanical sciatica: a review of 1092 cases
    Ismail Bejia
    Rheumatology Department, Monastir Hospital, EPS Monastir 5000, Tunisia
    Joint Bone Spine 71:567-71. 2004
    As an extremely common symptom and major source of lost productivity, mechanical sciatica places a heavy burden on public health.
  31. ncbi Surgical interventions for lumbar disc prolapse: updated Cochrane Review
    J N Alastair Gibson
    Spinal Unit, Royal Infirmary of Edinburgh and the University of Edinburgh, Edinburgh, Scotland
    Spine (Phila Pa 1976) 32:1735-47. 2007
    ..An updated Cochrane Review...
  32. ncbi New treatment of lumbar disc herniation involving 5-hydroxytryptamine2A receptor inhibitor: a randomized controlled trial
    Masahiro Kanayama
    Department of Orthopaedic Surgery, Hakodate Central General Hospital, Hakodate, Japan
    J Neurosurg Spine 2:441-6. 2005
    ..This prospective randomized controlled study was performed to evaluate the efficacy of the 5-HT2A receptor inhibitor in the treatment of symptomatic lumbar disc herniation...
  33. ncbi Epidural neuroplasty versus physiotherapy to relieve pain in patients with sciatica: a prospective randomized blinded clinical trial
    Andreas Veihelmann
    Department of Orthopaedics, Ludwig Maximilians University of Munich, Munich, Germany
    J Orthop Sci 11:365-9. 2006
    ..seems to be one of the promising minimally invasive techniques for adhesiolysis in patients with chronic sciatica with or without low back pain...
  34. pmc Sciatic: An archaic term
    Jeremy C T Fairbank
    BMJ 335:112. 2007
  35. pmc Prognostic factors in non-surgically treated sciatica: a systematic review
    Julie Ashworth
    Arthritis Research UK Primary Care Centre, Primary Care Sciences, Keele University, Staffordshire, UK
    BMC Musculoskelet Disord 12:208. 2011
    When present sciatica is considered an obstacle to recovery in low back pain patients, yet evidence is limited regarding prognostic factors for persistent disability in this patient group...
  36. ncbi The natural history of sciatica associated with disc pathology. A prospective study with clinical and independent radiologic follow-up
    K Bush
    Orthopaedic Medical Practice, London, United Kingdom
    Spine (Phila Pa 1976) 17:1205-12. 1992
    The purpose of this study was to assess the natural history of sciatica due to lumbosacral nerve root compromise and to evaluate the pathomorphologic changes that accompany the natural resolution of the disease...
  37. ncbi Magnetic resonance imaging findings as predictors of clinical outcome in patients with sciatica receiving active conservative treatment
    Tue Secher Jensen
    The Back Research Center, Ringe, Denmark
    J Manipulative Physiol Ther 30:98-108. 2007
    ..value of disk-related magnetic resonance imaging (MRI) findings in relation to recovery at 14 months in patients with severe sciatica, and whether improvement of disk herniation and/or nerve root compromise is concurrent with recovery.
  38. ncbi Ultrasound-guided piriformis injection: technique description and verification
    Jay Smith
    Department of Physical Medicine and Rehabilitation, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Arch Phys Med Rehabil 87:1664-7. 2006
    ..With appropriate training and experience, interested physiatrists can consider implementing ultrasound-guided piriformis injections into their clinical practices...
  39. ncbi Psychological screening in the surgical treatment of lumbar disc herniation
    E J Carragee
    Division of Orthopedic Surgery, Stanford University School of Medicine, California 94305, USA
    Clin J Pain 17:215-9. 2001
    ..As opposed to most "back pain syndromes," acute and subacute sciatica from disc hemiation has a very high chance of dramatic and lasting improvement with surgery...
  40. ncbi Neurotrophin-3 attenuates galanin expression in the chronic constriction injury model of neuropathic pain
    T D Wilson-Gerwing
    Department of Anatomy and Cell Biology, Cameco MS Neuroscience Research Center, University of Saskatchewan, 701 Queen Street, Saskatoon, Saskatchewan, Canada S7N 5E5
    Neuroscience 141:2075-85. 2006
    ..NT-3 infusion resulted in a limited reduction in the incidence and level of neuronal PACAP in medium to large size, but not small size, DRG neurons. NT-3 had no significant net effect on CCI-induced alterations in trkA mRNA expression...
  41. ncbi Diagnosis and management of piriformis syndrome: an osteopathic approach
    Lori A Boyajian-O'Neill
    Department of Family Medicine, Kansas City University of Medicine, Biosciences College of Osteopathic Medicine, 1750 Independence Ave, SEP 358, Kansas City, MO 64106 145, USA
    J Am Osteopath Assoc 108:657-64. 2008
    ..The authors note that several nonpharmacologic therapies, including osteopathic manipulative treatment, can be used alone or in conjunction with pharmacotherapeutic options in the management of piriformis syndrome...
  42. pmc Magnetic resonance imaging for diagnosing lumbar spinal pathology in adult patients with low back pain or sciatica: a diagnostic systematic review
    Merel Wassenaar
    Department of Health Sciences, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, The Netherlands
    Eur Spine J 21:220-7. 2012
    ..Consequently, this review aimed to summarize the available evidence on the diagnostic accuracy of MRI for identifying lumbar spinal pathology in adult low back pain (LPB) or sciatica patients.
  43. ncbi Lumbosacral radiculopathies: conservative approaches to management
    Anthony Chiodo
    Department of Physical Medicine Rehabilitation, University of Michigan Medical Center, 325 East Eisenhower Parkway, Ann Arbor, MI 48108, USA
    Phys Med Rehabil Clin N Am 13:609-21, viii. 2002
    The prevalence of sciatica in Western society and its economic and functional impact make it an important problem to understand for treatment...
  44. ncbi Targeted methylprednisolone acetate/hyaluronidase/clonidine injection after diagnostic epiduroscopy for chronic sciatica: a prospective, 1-year follow-up study
    Jos W Geurts
    Department of Anesthesiology, Rijnstate Hospital, Arnhem, The Netherlands
    Reg Anesth Pain Med 27:343-52. 2002
    ..We prospectively evaluated whether abnormalities at the lumbar level as diagnosed by magnetic resonance imaging (MRI) are confirmed by epiduroscopy, and assessed if targeted epidural injection of medication alleviates sciatic pain...
  45. ncbi Diagnosis and treatment of piriformis syndrome
    T Rodrigue
    Department of Neurosurgery, University Hospitals of Cleveland, Ohio, USA
    Neurosurg Clin N Am 12:311-9. 2001
    ..several factors: variable and sometimes unclear cause, similarity to other more easily recognizable causes of sciatica, lack of consistent objective diagnostic findings, and relative rarity...
  46. ncbi Randomized, double-blind, placebo-controlled, dose-response, and preclinical safety study of transforaminal epidural etanercept for the treatment of sciatica
    Steven P Cohen
    Department of Anesthesiology, Johns Hopkins School of Medicine, Baltimore, MD 21029, USA
    Anesthesiology 110:1116-26. 2009
    ..One variable that may have contributed to poor outcomes is low drug levels at the site of nerve inflammation. To date, no studies have evaluated the efficacy or safety of epidurally administered anti-tumor necrosis factor agents...
  47. ncbi Chiropractic manipulation in the treatment of acute back pain and sciatica with disc protrusion: a randomized double-blind clinical trial of active and simulated spinal manipulations
    Valter Santilli
    Direttore Cattedra Medicina Fisica e Riabilitativa, Universita di Roma La Sapienza, P le Aldo Moro 5, Roma, Rome, 00185, Italy
    Spine J 6:131-7. 2006
    Acute back pain and sciatica are major sources of disability. Many medical interventions are available, including manipulations, with conflicting results.
  48. ncbi Spinal manipulation, epidural injections, and self-care for sciatica: a pilot study for a randomized clinical trial
    Gert Bronfort
    Wolfe Harris Center for Clinical Studies, Northwestern Health Sciences University, Bloomington, MN 55431, USA
    J Manipulative Physiol Ther 27:503-8. 2004
    To assess the feasibility of recruiting sciatica patients and to evaluate their compliance in preparation for a full-scale randomized clinical trial. We also aimed to determine the responsiveness of key outcome measures.
  49. ncbi Reliability, validity, and responsiveness of the Norwegian versions of the Maine-Seattle Back Questionnaire and the Sciatica Bothersomeness and Frequency Indices
    Lars Grøvle
    Department of Rheumatology, Østfold Hospital Trust, Norway
    Spine (Phila Pa 1976) 33:2347-53. 2008
    Cross-sectional and prospective study of patients with sciatica and disc herniation.
  50. pmc Morphine, nortriptyline and their combination vs. placebo in patients with chronic lumbar root pain
    Suzan Khoromi
    Section on Developmental Genetic Epidemiology, National Institute of Mental Health, Department of Health and Human Services, Bethesda, MD 20892 3720, USA
    Pain 130:66-75. 2007
    ..25-1 mg) in patients with chronic sciatica. Each period consisted of 5 weeks of dose escalation, 2 weeks of maintenance at the highest tolerated doses, and ..
  51. pmc Prolonged conservative care versus early surgery in patients with sciatica from lumbar disc herniation: cost utility analysis alongside a randomised controlled trial
    Wilbert B Van Den Hout
    Department of Medical Decision Making, Leiden University Medical Center, PO Box 9600, 2300RC Leiden, Netherlands
    BMJ 336:1351-4. 2008
    To determine whether the faster recovery after early surgery for sciatica compared with prolonged conservative care is attained at reasonable costs.
  52. ncbi Natural history and prognostic indicators of sciatica
    Florence Tubach
    INSERM U88, Hopital National de Saint Maurice, 94415 Saint Maurice Cedex, France
    J Clin Epidemiol 57:174-9. 2004
    b>Sciatica is thought to have a good clinical outcome, but in fact, its natural history is not well known.
  53. ncbi Consistency of history taking and physical examination in patients with suspected lumbar nerve root involvement
    P C Vroomen
    Department of Neurology, Maastricht University Hospital, The Netherlands
    Spine (Phila Pa 1976) 25:91-6; discussion 97. 2000
    ..A cross-sectional study of interobserver variability in primary care patients...
  54. pmc Diagnostic value of history and physical examination in patients suspected of lumbosacral nerve root compression
    P C A J Vroomen
    Department of Neurology, Maastricht University Hospital, Maastricht, The Netherlands
    J Neurol Neurosurg Psychiatry 72:630-4. 2002
    To evaluate patient characteristics, symptoms, and examination findings in the clinical diagnosis of lumbosacral nerve root compression causing sciatica.
  55. pmc Effectiveness of conservative treatments for the lumbosacral radicular syndrome: a systematic review
    Pim A J Luijsterburg
    Erasmus MC, General Practice, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Eur Spine J 16:881-99. 2007
    ..To assess the effectiveness of conservative treatments of the lumbosacral radicular syndrome (sciatica). Relevant electronic databases and the reference lists of articles up to May 2004 were searched...
  56. pmc Physical therapy plus general practitioners' care versus general practitioners' care alone for sciatica: a randomised clinical trial with a 12-month follow-up
    Pim A J Luijsterburg
    Department of General Practice, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur Spine J 17:509-17. 2008
    A randomised clinical trial in primary care with a 12-months follow-up period. About 135 patients with acute sciatica (recruited from May 2003 to November 2004) were randomised in two groups: (1) the intervention group received physical ..
  57. ncbi Sciatica: review of epidemiological studies and prevalence estimates
    Kika Konstantinou
    Primary Care Musculoskeletal Research Centre, Primary Care Sciences, Keele University Staffordshire, UK
    Spine (Phila Pa 1976) 33:2464-72. 2008
    Review of studies on sciatica prevalence and synthesis of available evidence.
  58. ncbi Incidence of sciatic pain among men in machine operating, dynamic physical work, and sedentary work. A three-year follow-up
    H Riihimaki
    Institute of Occupational Health, Helsinki, Finland
    Spine (Phila Pa 1976) 19:138-42. 1994
    ..4 (1.0-1.9) and 1.5 (1.1-2.1), respectively. Previous history of severe lumbago or other low-back pain increased the risk fourfold. Frequent physical exercise and smoking were of borderline significance as predictors...
  59. ncbi Is the interleukin-6 haplotype a prognostic factor for sciatica?
    Jaro Karppinen
    Musculoskeletal Centre, Finnish Institute of Occupational Health, Aapistie 1, 90220 Oulu, Finland
    Eur J Pain 12:1018-25. 2008
    We have shown in a cross-sectional setting that an IL6 haplotype (GGGA) is associated with intervertebral disc disease (IDD) characterized by sciatica. The aim of this study was to evaluate the prognostic role of the GGGA haplotype in IDD.
  60. pmc Cardiovascular and lifestyle risk factors in lumbar radicular pain or clinically defined sciatica: a systematic review
    Rahman Shiri
    Musculoskeletal Disorders, Finnish Institute of Occupational Health, Topeliuksenkatu 41a A, 00250, Helsinki, Finland
    Eur Spine J 16:2043-54. 2007
    ..systematic reviews on associations between cardiovascular or lifestyle risk factors and lumbar radicular pain or sciatica. The aim of this systematic literature review was to assess associations between these risk factors and lumbar ..
  61. pmc Diagnosis and treatment of sciatica
    B W Koes
    Department of General Practice, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, Netherlands
    BMJ 334:1313-7. 2007
  62. ncbi Diagnostic evaluation of low back pain with emphasis on imaging
    Jeffrey G Jarvik
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    Ann Intern Med 137:586-97. 2002
    ..To review evidence on the diagnostic accuracy of clinical information and imaging for patients with low back pain in primary care settings...
  63. ncbi Efficacy of steroid and nonsteroid caudal epidural injections for low back pain and sciatica: a prospective, randomized, double-blind clinical trial
    Fares E Sayegh
    3rd Orthopaedic Department, Aristotle University of Thessaloniki Medical School, Papageorgiou General Hospital, Thessaloniki, Greece
    Spine (Phila Pa 1976) 34:1441-7. 2009
    ..Prospective, double-blind, randomized, case-control study...
  64. pmc The bothersomeness of sciatica: patients' self-report of paresthesia, weakness and leg pain
    Lars Grøvle
    Department of Rheumatology, Østfold Hospital Trust, Fredrikstad, Norway
    Eur Spine J 19:263-9. 2010
    The objective of the study was to investigate how patients with sciatica due to disc herniation rate the bothersomeness of paresthesia and weakness as compared to leg pain, and how these symptoms are associated with socio-demographic and ..
  65. ncbi Efficacy of infliximab for disc herniation-induced sciatica: one-year follow-up
    Timo Korhonen
    Department of Physical Medicine and Rehabilitation, Oulu University Hospital, Oulu, Finland
    Spine (Phila Pa 1976) 29:2115-9. 2004
    ..An open-label trial...
  66. ncbi Adalimumab in severe and acute sciatica: a multicenter, randomized, double-blind, placebo-controlled trial
    Stephane Genevay
    Hôpital Beau Séjour, University Hospitals of Geneva, Geneva, Switzerland
    Arthritis Rheum 62:2339-46. 2010
    ..Based on several experimental results and on a preliminary study, a trial was undertaken to assess the efficacy of adalimumab, a tumor necrosis factor alpha inhibitor, in patients with radicular pain due to lumbar disc herniation...
  67. ncbi Cyclic sciatica from extrapelvic endometriosis affecting the sciatic nerve
    John R Floyd
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Neurosurg Spine 14:281-9. 2011
    ..The authors describe a woman with catamenial sciatica caused by endometriosis affecting the sciatic nerve trunk in the upper thigh...
  68. ncbi Diagnostic accuracy of the clinical examination in identifying the level of herniation in patients with sciatica
    Mark J Hancock
    Faculty of Health Sciences, University of Sydney, Australia
    Spine (Phila Pa 1976) 36:E712-9. 2011
    ..Cross sectional..
  69. ncbi A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats
    M Chacur
    Laboratory of Pathophysiology, Butantan Institute, Avenue Vital Brazil, 1500, 05503-900 Sao Paulo, SP, Brazil
    Pain 94:231-44. 2001
    ..Since many clinical neuropathies result from inflammation/infection of peripheral nerves rather than frank physical trauma, understanding how immune activation alters pain processing may suggest novel approaches to pain control...
  70. ncbi Thoracic disk herniation manifesting as sciatica-like pain--two case reports
    Hyung Lea Cho
    Department of Neurosurgery, Wooridul Spine Hospital, Seoul, Korea
    Neurol Med Chir (Tokyo) 51:67-71. 2011
    Two patients presented with sciatica-like pain caused by thoracic disk herniation...
  71. ncbi Lamotrigine for intractable sciatica: correlation between dose, plasma concentration and analgesia
    Elon Eisenberg
    Pain Relief Unit, Rambam Medical Center, The B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Eur J Pain 7:485-91. 2003
    ..Study results suggest lamotrigine is a potentially effective and safe compound for the treatment of painful lumbar radiculopathy, and that it is likely to act in a dose- and plasma concentration-dependent fashion...
  72. ncbi Personal and occupational predictors of sciatica in the GAZEL cohort
    A Leclerc
    INSERM U88 IFR69, Hopital National de Saint Maurice, St Maurice, France
    Occup Med (Lond) 53:384-91. 2003
    The objectives of this prospective study were to investigate personal and occupational predictors of sciatica and to compare the risk factors for sciatica and those for low back pain without sciatica.
  73. ncbi The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica and disability after lumbar disc herniation
    L M Jacobsen
    National Institute of Occupational Health, Oslo, Norway
    Eur J Pain 16:1064-9. 2012
    ..A functional polymorphism in the gene encoding this enzyme, i.e. the COMT Val158Met SNP that reduces enzyme activity, has previously been linked to pain sensitivity...
  74. pmc Designing an implementation strategy to improve interprofessional shared decision making in sciatica: study protocol of the DISC study
    Stefanie N Hofstede
    Department of Medical Decision Making, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Implement Sci 7:55. 2012
    b>Sciatica is a common condition worldwide that is characterized by radiating leg pain and regularly caused by a herniated disc with nerve root compression...
  75. ncbi Relationship between severity of lumbar disc disease and disability scores in sciatica patients
    Francois Porchet
    Department of Neurosurgery, University of Lausanne, Lausanne, Switzerland
    Neurosurgery 50:1253-9; discussion 1259-60. 2002
    To study the association between the clinical examination and the radiological assessment of lumbar disc disease in patients with sciatica.
  76. ncbi Cost-effectiveness and safety of epidural steroids in the management of sciatica
    C Price
    Pain Clinic, Royal South Hants Hospital, Southampton, UK
    Health Technol Assess 9:1-58, iii. 2005
    To investigate the clinical effectiveness of epidural steroid injections (ESIs) in the treatment of sciatica with an adequately powered study and to identify potential predictors of response to ESIs...
  77. ncbi Safety and efficacy of chymopapain (Discase) in the treatment of sciatica due to a herniated nucleus pulposus. Results of a randomized, double-blind study
    E J Dabezies
    Division of Neurosurgery, University of Massachusetts Medical Center, Worcester
    Spine (Phila Pa 1976) 13:561-5. 1988
    ..placebo (cysteine-edetate-iothalamate: CEI) for lumbar intervertebral disc rupture with sciatica was carried out on 173 patients, the largest such study reported to date...
  78. ncbi Low back pain and sciatica prevalence and intensity reported in a Mediterranean country: ordinal logistic regression analysis
    Panagiotis Korovessis
    Orthopedic Department, General Hospital Agios Andreas, 1 Tsertidou St, 26224 Patras, Greece
    Orthopedics 35:e1775-84. 2012
    ..this retrospective cross-sectional study was to estimate the 6-month prevalence and severity of low back pain and sciatica in a representative sample of an adult Mediterranean population...
  79. ncbi Sciatica caused by epidural gas. Four case reports
    F Giraud
    Rheumatology and Bony Pathology Department, , Lyon, France
    Joint Bone Spine 68:434-7. 2001
    We report four cases of sciatica caused by gas in the epidural space with no other abnormality. Only 21 similar cases have been reported...
  80. ncbi Tumor necrosis alpha-blocking agent (etanercept): a triple blind randomized controlled trial of its use in treatment of sciatica
    Tosan Okoro
    Department of Orthopaedics and Trauma, University Hospitals Leicester, Leicester, UK
    J Spinal Disord Tech 23:74-7. 2010
    ..Triple blind randomized controlled study...
  81. ncbi Management of sciatica due to lumbar disc herniation in the Netherlands: a survey among spine surgeons
    Mark P Arts
    Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands
    J Neurosurg Spine 9:32-9. 2008
    Although clinical guidelines for sciatica have been developed, various aspects of lumbar disc herniation remain unclear, and daily clinical practice may vary...
  82. ncbi Symptoms of distress as prospective predictors of pain-related sciatica treatment outcomes
    Robert R Edwards
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 1 108, Baltimore, MD 21287, United States
    Pain 130:47-55. 2007
    Prior studies evaluating predictors of pain-related outcomes following treatment for sciatica have been limited by methodological problems, including retrospective study design, use of unvalidated outcome measures, and short-term follow-..
  83. ncbi Natural history of low back pain. A longitudinal study in nurses
    J Smedley
    Medical Research Council Environmental Epidemiology Unit, University of Southampton, United Kingdom
    Spine (Phila Pa 1976) 23:2422-6. 1998
    ..Back pain carried a worse prognosis if it was disabling or associated with sciatica. CONCLUSIONS: Our results confirm the importance of back pain duration and the occurrence of associated ..
  84. ncbi Morphological analysis in patients with sciatica: a magnetic resonance imaging study using three-dimensional high-resolution diffusion-weighted magnetic resonance neurography techniques
    Zhongwei Zhang
    Department of Radiology, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong, People s Republic of China
    Spine (Phila Pa 1976) 34:E245-50. 2009
    A prospective observational study of patients with sciatica.
  85. ncbi Influence of gender and other prognostic factors on outcome of sciatica
    Wilco C Peul
    Department of Neurosurgery, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Pain 138:180-91. 2008
    b>Sciatica caused by a lumbar disk herniation is a frequently diagnosed disorder with a favorable natural course. While most prognostic studies focus on good outcome, patients might experience unsatisfactory results...
  86. ncbi Extraspinal bone and soft-tissue tumors as a cause of sciatica. Clinical diagnosis and recommendations: analysis of 32 cases
    J Bickels
    Department of Orthopedic Oncology, Washington Cancer Institute, Washington DC, USA
    Spine (Phila Pa 1976) 24:1611-6. 1999
    STUDY DESIGN: Between 1982 and 1997, the authors treated 32 patients with sciatica who subsequently were found to have a tumor along the extraspinal course of the sciatic nerve...
  87. ncbi Responsiveness of common outcome measures for patients with low back pain
    S J Taylor
    Orthopaedic Department, Princess Margaret Hospital, Swindon, United Kingdom
    Spine (Phila Pa 1976) 24:1805-12. 1999
    A prospective cohort study assessing the responsiveness of two disease-specific questionnaires and a generic health questionnaire for patients with low back pain and sciatica.
  88. ncbi The treatment of disc-herniation-induced sciatica with infliximab: one-year follow-up results of FIRST II, a randomized controlled trial
    Timo Korhonen
    Department of Physical Medicine and Rehabilitation, Oulu University Hospital, Oulu, Finland
    Spine (Phila Pa 1976) 31:2759-66. 2006
    ..A randomized controlled trial...
  89. ncbi Report of a controlled clinical trial comparing automated percutaneous lumbar discectomy and microdiscectomy in the treatment of contained lumbar disc herniation
    S Chatterjee
    Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom
    Spine (Phila Pa 1976) 20:734-8. 1995
    ..CONCLUSION. In this group of patients, APLD is seen to be ineffective in the treatment of contained lumbar disc herniation...
  90. ncbi Tubular diskectomy vs conventional microdiskectomy for the treatment of lumbar disk-related sciatica: cost utility analysis alongside a double-blind randomized controlled trial
    M Elske van den Akker
    Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands
    Neurosurgery 69:829-35; discussion 835-6. 2011
    Conventional microdiskectomy is the most frequently performed surgery for patients with sciatica caused by lumbar disk herniation...
  91. ncbi The pain provocation-based straight leg raise test for diagnosis of lumbar disc herniation, lumbar radiculopathy, and/or sciatica: a systematic review of clinical utility
    Vincent Scaia
    Divisionof Physical Therapy, WalshUniversity, 2020 East Maple Street, North Canton, OH 44720, USA
    J Back Musculoskelet Rehabil 25:215-23. 2012
    The purpose of this study was to investigate the diagnostic accuracy of a finding of pain during the straight leg raise test for lumbar disc herniation, lumbar radiculopathy, and/or sciatica.
  92. ncbi Extraspinal sciatica revealing late metastatic disease from parotid carcinoma
    Audrey Petit Le Manac'h
    Service de Rhumatologie, CHU d Angers, 4, rue Larrey, 49933 Angers Cedex, France
    Joint Bone Spine 77:64-6. 2010
    b>Sciatica is a clinical symptom usually caused by a disk herniation and less often by other conditions such as tumors, infections, or inflammatory diseases...
  93. ncbi Physical exercise and musculoskeletal pain among forest industry workers
    H Miranda
    Finnish Institute of Occupational Health, Helsinki
    Scand J Med Sci Sports 11:239-46. 2001
    ..In addition, the other factors which are strongly related to pain (such as mental stress and work-related physical loading) should be taken into account...
  94. ncbi Lack of effectiveness of bed rest for sciatica
    P C Vroomen
    Department of Neurology, Maastricht University Hospital, The Netherlands
    N Engl J Med 340:418-23. 1999
    Bed rest is widely advocated for sciatica, but its effectiveness has not been established...
  95. ncbi Extraspinal causes of sciatica. A case report
    S Dudeney
    Department of Orthopedic Surgery, Beaumont Hospital, Dublin, Ireland
    Spine (Phila Pa 1976) 23:494-6. 1998
    ..It is as an example of one of the many extraspinal causes of sciatica. OBJECTIVE: To demonstrate the importance of clinical examination in the assessment of patients with sciatic, ..
  96. pmc Proinflammatory cytokines in cerebrospinal fluid and serum in patients with disc herniation and sciatica
    H Brisby
    Department of Orthopaedics, Goteborg University, Sahlgrenska University Hospital, Gothenburg, Sweden
    Eur Spine J 11:62-6. 2002
    ..using the enzyme-linked immunosorbent assay (ELISA) technique in 39 patients with lumbar disc herniation and sciatica. Pain duration and pain intensity (visual analogue scale, VAS) were recorded at inclusion, and a clinical ..
  97. ncbi Massage therapy helps to increase range of motion, decrease pain and assist in healing a client with low back pain and sciatica symptoms
    Jada Bell
    J Bodyw Mov Ther 12:281-9. 2008
    This study evaluated the effectiveness of massage therapy as a component in increasing range of motion (ROM), decreasing pain and assisting in healing of a client with low back pain (LBP) and sciatica symptoms.
  98. ncbi [Sciatica due to unusual causes: Tarlov cysts and nerve roots anomalies]
    M Younes
    Service de Rhumatologie, EPS de Monastir, 5000 Monastir, Tunisie
    Rev Neurol (Paris) 165:282-7. 2009
    ..impingement (disc hernia, spondylolisthesis or lumbar canal stenosis) these anomalies can be responsible for sciatica, motor deficit and bladder sphincter dysfunction...
  99. ncbi An unusual cause of sciatica. A case report
    C T Servant
    Department of General Surgery, Harold Wood Hospital, Essex, England
    Spine (Phila Pa 1976) 23:2134-6. 1998
    STUDY DESIGN: This case report illustrates the need to be aware of extraspinal causes of sciatica. A patient with a strangulated sciatic hernia showed the clinical features of sciatic leg pain, intestinal obstruction, and a left gluteal ..
  100. pmc Sciatica in the female patient: anatomical considerations, aetiology and review of the literature
    Abdul Wahab T Al-Khodairy
    Clinique Romande de Réadaptation SuvaCare, Sion, Switzerland
    Eur Spine J 16:721-31. 2007
    ..department for investigation and eventual surgical treatment for what was suspected to be herniated disc-related sciatica. Removal of her enlarged uterus found unexpectedly close to the sacroiliac joint upon lumbar MRI abolished her ..
  101. ncbi Chronic inflammation and compression of the dorsal root contribute to sciatica induced by the intervertebral disc herniation in rats
    Shu xun Hou
    Institute of Orthopedics, 304 Hospital of PLA, 51 Fucheng Road, Beijing 100037, PR China
    Pain 105:255-64. 2003
    The pathophysiological mechanisms underlying sciatica and back pain are not well understood. In the present study, a sciatica model was developed to investigate the contributions of inflammation and compression of the dorsal root (DR)...

Research Grants29

  1. MECHANICAL STIMULATION OF IVD CELLS
    Lori A Setton; Fiscal Year: 2013
    ..cytokine expression and compression of the nerve roots that may contribute to a painful lumbar radiculopathy (sciatica)...
  2. Do Patient Requests Affect Doctor's Decisions? A Complementary Experimental and Q
    John B McKinlay; Fiscal Year: 2012
    ..Within a single, cost-efficient study, we propose two experiments focusing on common medical conditions (sciatica and osteoarthritis of the knee) which generate high levels of healthcare utilization, prescribing and costs, to ..
  3. CA8 Variants: New Mechanisms Underlying Transitions to Persistent Pain Syndromes
    Eden R Martin; Fiscal Year: 2013
    ..one or more common persistent pain syndromes including temporomandibular disease (TMD), TMD with widespread pain, sciatica, post-herpetic neuralgia (PHN), neuropathic pain after spinal cord injury (SCI), and osteoarthritis (OA)...
  4. PET/MRI Imaging of Neuraxial Inflammation in Sciatica Patients
    Yi Zhang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A fundamental question in managing sciatica pain remains unanswered: Is chronic sciatica pain mediated by persistent inflammation? Sciatica refers to back pain with a radicular component...
  5. Biological and clinical outcomes of chiropractic spinal manipulative therapy in t
    PAUL BURTON BISHOP; Fiscal Year: 2013
    ..trial (RCT) and nested cohort study of the effect of HVAL-SMT on cytokine expression in patients with acute sciatica secondary to lumbar disc herniation (AS-LDH)...
  6. Steroid Delivery in Acute Herniated Lumbar Disc with Radiculopathy
    Harley Goldberg; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Acute sciatica due to a herniated lumbar vertebral disc is one of the most common and disabling conditions affecting the spine...
  7. Race in Physician Decision to Prescribe Opioid Analgesia
    JOSHUA SARVER; Fiscal Year: 2002
    ..determine: 1) the effect of race on physicians? use of analgesics for 3 acute, painful conditions (back pain with sciatica, ankle fracture, and migraine headache); 2) whether providing information on patients? socioeconomic status, role ..
  8. MUTATIONS CAUSING DISC DISEASE AND SCIATICA
    Leena Ala Kokko; Fiscal Year: 2003
    Low back pain and sciatica are the most common musculoskeletal complaints...
  9. MAINE LUMBAR SPINE STUDY
    Robert Keller; Fiscal Year: 2001
    ..The MLSS, initially funded as part of the Low Back Pain PORT, enrolled over 600 patients with either sciatica or spinal stenosis in 1990/92...
  10. STUDY OF CHEMOGENIC LOW BACK PAIN
    Jun Ming Zhang; Fiscal Year: 2003
    ..The overall goal of our research is to better understand the etiology and mechanisms of low back pain and sciatica. Clinical studies indicate that degenerative changes and traumatic injuries of the spine are often associated ..
  11. NEUROPHYSIOLOGY OF THE LUMBAR DISC AND ADJACENT TISSUE
    John Cavanaugh; Fiscal Year: 2001
    ..disc and adjacent tissue lead to low back pain, while the effects on dorsal roots and dorsal root ganglia lead to sciatica. The specific aims of the proposal are to examine these mechanisms using neurophysiological, histological, ..
  12. LOW BACK PAIN & SCIATICA: FACTORS FOR SUCCESS OF THERAPY
    Donlin Long; Fiscal Year: 1991
    ..Analyses of these data should provide a valid predictive system to improve selection of therapy and prediction of outcome...
  13. Low Back Pain Quantifying Risk Factors
    Arun Garg; Fiscal Year: 2005
    ..rates and subsequent incidence rates over a 2 year period for low back pain (LBP), LBP with neurological signs (sciatica), LBP-related impairments, lost time and modified duty-related LBP for 3 levels of job physical exposures (low, ..
  14. DETERMINANTS OF LOW-BACK-PAIN HEALTH CARE UTILIZATION
    Eric Hurwitz; Fiscal Year: 1993
    ..how health services utilization differs among persons with low-back conditions, primarily low-back pain and sciatica. The study's specific aim is to assess the relationship between potential risk factors for use of health services ..
  15. Back pain Outcomes using Longitudinal Data (BOLD)
    Jeffrey G Jarvik; Fiscal Year: 2010
    ....
  16. RAPID MR VS XRAY: RANDOMIZED OUTCOME TRIAL FOR BACK PAIN
    JEFFREY JARVIK; Fiscal Year: 2001
    ..We have a window of opportunity before the rapid MRI becomes widely disseminated and a randomized trial is made impossible by the expectations of both patients and physicians. ..
  17. Chiropractic, Medication, and Self-care for Neck Pain
    Gert Bronfort; Fiscal Year: 2005
    ..It will also provide clinically useful information for health care practitioners, policy makers and, most importantly, those who suffer from this painful and costly condition. ..
  18. Matrix metalloproteinases as biomarkers of neurodegeneration
    Veronica Shubayev; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  19. COLLAGEN CROSS-LINKING IN SKELETAL AGING AND DISEASE
    David R Eyre; Fiscal Year: 2010
    ..In parallel with basic tissue studies, collagen fragments in urine are being examined by similar methods as potential non-invasive biomarkers of a patient's bone and joint health. ..
  20. LBP with Radiculopathy: An Inflammatory Response
    JOYCE DELEO; Fiscal Year: 2005
    ..This new knowledge will guide development of novel, non-addictive preventive therapies and treatments for chronic low back pain. ..
  21. Alternatives to Opioids for Chronic Pain: Part IV
    Joyce A DeLeo; Fiscal Year: 2010
    ..The results from these multidisciplinary studies may culminate in novel pharmacopeia to treat and prevent chronic neuropathic pain and thus, has the potential for high clinical impact. ..
  22. Microglial Regulation in Opioid Tolerance, Hyperalgesia and Addiction
    JOYCE DELEO; Fiscal Year: 2009
    ..These studies may also aid in elucidating substance abuse-induced plasticity, the physiological correlate to craving and relapse in drug addiction. ..
  23. Dose-Response of Manipulation for Chronic Headache
    Mitchell Haas; Fiscal Year: 2006
    ..The second is to estimate dose and efficacy parameters for a larger study for determining the relationship of cervicogenic headache outcomes with the number of treatments. [unreadable] [unreadable]..
  24. Diet, Obesity and Stress
    Yvonne Ulrich Lai; Fiscal Year: 2005
    ..abstract_text> ..
  25. NIAMS Muiltidisciplinary Clinical Research Center in...
    Richard Deyo; Fiscal Year: 2006
    ..It will require computer modeling, based on precedents in MR-PET scanning. We will determine if surgeons will accept the synthesized images as a replacement for CT-myelography for purposes of surgical planning. ..
  26. Catastrophizing and Pain in Rheumatoid Arthritis
    Robert Edwards; Fiscal Year: 2008
    ..abstract_text> ..
  27. Individual Differences in Pain Modulation as Predictors of Post-Surgical Pain
    Robert Edwards; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. UW Multidisciplinary Clinical Research Training (RMI)
    Richard Deyo; Fiscal Year: 2004
    ....
  29. NOCICEPTOR AXONS AND NEURAL INFLAMMATION
    Geoffrey Bove; Fiscal Year: 2002
    ..The information provided by the proposed studies will help form a foundation for development of an animal model of chronic, movement-induced musculoskeletal pain. ..