neuralgia

Summary

Summary: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.

Top Publications

  1. ncbi Pharmacologic management of neuropathic pain: evidence-based recommendations
    Robert H Dworkin
    University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Pain 132:237-51. 2007
  2. ncbi Neuropathic pain: redefinition and a grading system for clinical and research purposes
    R D Treede
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Neurology 70:1630-5. 2008
  3. pmc Neuropathic pain: a maladaptive response of the nervous system to damage
    Michael Costigan
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Annu Rev Neurosci 32:1-32. 2009
  4. ncbi Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values
    R Rolke
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Pain 123:231-43. 2006
  5. ncbi EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision
    N Attal
    INSERM U 987, Centre dEvaluation et de Traitement de la Douleur, Hô pital Ambroise Paré, APHP, Boulogne Billancourt, France
    Eur J Neurol 17:1113-e88. 2010
  6. ncbi Prevalence of chronic pain with neuropathic characteristics in the general population
    Didier Bouhassira
    INSERM U 792, Centre de Traitement et d Evaluation de la Douleur, CHU Ambroise Pare, 9, avenue Charles de Gaulle, Boulogne Billancourt cedex F 92100, France
    Pain 136:380-7. 2008
  7. ncbi A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults
    M N Oxman
    Shingles Prevention Study Mail code 111F 1, VA San Diego Healthcare System, 3350 La Jolla Village Dr, San Diego, CA 92161, USA
    N Engl J Med 352:2271-84. 2005
  8. ncbi Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4)
    Didier Bouhassira
    INSERM E 332, AP HP Hôpital Ambroise Paré, Boulogne and Université Versailles Saint Quentin, France
    Pain 114:29-36. 2005
  9. ncbi Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex
    Xiang yao Li
    Department of Physiology, Faculty of Medicine, Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Science 330:1400-4. 2010
  10. ncbi The neuropathic pain triad: neurons, immune cells and glia
    Joachim Scholz
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Neurosci 10:1361-8. 2007

Detail Information

Publications342 found, 100 shown here

  1. ncbi Pharmacologic management of neuropathic pain: evidence-based recommendations
    Robert H Dworkin
    University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Pain 132:237-51. 2007
    ..Long-term studies, head-to-head comparisons between medications, studies involving combinations of medications, and RCTs examining treatment of central NP are lacking and should be a priority for future research...
  2. ncbi Neuropathic pain: redefinition and a grading system for clinical and research purposes
    R D Treede
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Neurology 70:1630-5. 2008
    ..The grades probable and definite require confirmatory evidence from a neurologic examination. This grading system is proposed for clinical and research purposes...
  3. pmc Neuropathic pain: a maladaptive response of the nervous system to damage
    Michael Costigan
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Annu Rev Neurosci 32:1-32. 2009
    ..Treatment needs to move from merely suppressing symptoms to a disease-modifying strategy aimed at both preventing maladaptive plasticity and reducing intrinsic risk...
  4. ncbi Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values
    R Rolke
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Pain 123:231-43. 2006
    ..Application of this standardized QST protocol in patients and human surrogate models will allow to infer underlying mechanisms from somatosensory phenotypes...
  5. ncbi EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision
    N Attal
    INSERM U 987, Centre dEvaluation et de Traitement de la Douleur, Hô pital Ambroise Paré, APHP, Boulogne Billancourt, France
    Eur J Neurol 17:1113-e88. 2010
    ..This second European Federation of Neurological Societies Task Force aimed at updating the existing evidence about the pharmacological treatment of neuropathic pain since 2005...
  6. ncbi Prevalence of chronic pain with neuropathic characteristics in the general population
    Didier Bouhassira
    INSERM U 792, Centre de Traitement et d Evaluation de la Douleur, CHU Ambroise Pare, 9, avenue Charles de Gaulle, Boulogne Billancourt cedex F 92100, France
    Pain 136:380-7. 2008
    ..We identified distinctive socio-demographic profile and clinical features indicating that chronic pain with neuropathic characteristics is a specific health problem...
  7. ncbi A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults
    M N Oxman
    Shingles Prevention Study Mail code 111F 1, VA San Diego Healthcare System, 3350 La Jolla Village Dr, San Diego, CA 92161, USA
    N Engl J Med 352:2271-84. 2005
    The incidence and severity of herpes zoster and postherpetic neuralgia increase with age in association with a progressive decline in cell-mediated immunity to varicella-zoster virus (VZV)...
  8. ncbi Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4)
    Didier Bouhassira
    INSERM E 332, AP HP Hôpital Ambroise Paré, Boulogne and Université Versailles Saint Quentin, France
    Pain 114:29-36. 2005
    ..The most common aetiologies of nervous lesions (n=89) were traumatic nerve injury, post herpetic neuralgia and post stroke pain...
  9. ncbi Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex
    Xiang yao Li
    Department of Physiology, Faculty of Medicine, Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Science 330:1400-4. 2010
    ..Microinjection of ZIP into the ACC blocked behavioral sensitization. These results suggest that PKMζ in the ACC acts to maintain neuropathic pain. PKMζ could thus be a new therapeutic target for treating chronic pain...
  10. ncbi The neuropathic pain triad: neurons, immune cells and glia
    Joachim Scholz
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Neurosci 10:1361-8. 2007
    ....
  11. ncbi The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines
    Paul J Austin
    School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    J Neuroimmunol 229:26-50. 2010
    ....
  12. pmc Recommendations for the pharmacological management of neuropathic pain: an overview and literature update
    Robert H Dworkin
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Mayo Clin Proc 85:S3-14. 2010
    ..The objectives of the current article are to review the Neuropathic Pain Special Interest Group guidelines for the pharmacological management of neuropathic pain and to provide a brief overview of these recent studies...
  13. ncbi The role of the immune system in the generation of neuropathic pain
    Margarita Calvo
    Department of Neurorestoration, Wolfson CARD, King s College London, London, UK
    Lancet Neurol 11:629-42. 2012
    ..An important challenge for the future is to establish to what extent this immune response initiates or maintains neuropathic pain in patients and thus whether it is amenable to therapy...
  14. ncbi NeuPSIG guidelines on neuropathic pain assessment
    Maija Haanpää
    Rehabilitation ORTON, Helsinki, Finland
    Pain 152:14-27. 2011
    ..Measurement of trigeminal reflexes mediated by A-beta fibers can be used to differentiate symptomatic trigeminal neuralgia from classical trigeminal neuralgia...
  15. ncbi The evidence for pharmacological treatment of neuropathic pain
    Nanna Brix Finnerup
    Department of Neurology and Danish Pain Research Center, Aarhus University Hospital, Aarhus, Denmark
    Pain 150:573-81. 2010
    ..Painful poly-neuropathy (most often due to diabetes) was examined in 69 studies, postherpetic neuralgia in 23, while peripheral nerve injury, central pain, HIV neuropathy, and trigeminal neuralgia were less often ..
  16. pmc JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain
    Yong Jing Gao
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 29:4096-108. 2009
    ..Inhibition of the JNK/MCP-1 pathway may provide a new therapy for neuropathic pain management...
  17. ncbi CCL2 released from neuronal synaptic vesicles in the spinal cord is a major mediator of local inflammation and pain after peripheral nerve injury
    Juliette Van Steenwinckel
    PAIN Group, Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, Universite Pierre et Marie Curie, Inserm Unité Mixte de Recherche en Santé 975, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7225, 75013 Paris, France
    J Neurosci 31:5865-75. 2011
    ..Our data demonstrate that CCL2 has the typical characteristics of a neuronal mediator involved in nociceptive signal processing and that antagonists of its receptor are promising agents from treating neuropathic pain...
  18. ncbi p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
    Ru Rong Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Neuron 36:57-68. 2002
    ....
  19. ncbi Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment
    Ralf Baron
    Sektion für Neurologische Schmerzforschung und therapie, Klinik fur Neurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel, Germany
    Lancet Neurol 9:807-19. 2010
    ..Examples of neuropathic pain include painful polyneuropathy, postherpetic neuralgia, trigeminal neuralgia, and post-stroke pain...
  20. ncbi Treatment of neuropathic pain: an overview of recent guidelines
    Alec B O'Connor
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Med 122:S22-32. 2009
    ..For all treatments for neuropathic pain, long-term studies, head-to-head comparisons, and studies of treatment combinations are a priority for future research...
  21. ncbi Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway
    Stefania Echeverry
    The Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec H3A 2B2, Canada
    J Neurosci 31:10819-28. 2011
    ..These findings highlight the importance of inflammation in BSCB integrity and in spinal cord homeostasis...
  22. pmc Chemokines, neuronal-glial interactions, and central processing of neuropathic pain
    Yong Jing Gao
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, United States
    Pharmacol Ther 126:56-68. 2010
    ..Insights into the role of chemokines in neuronal-glial interactions after nerve injury will identify new targets for therapeutic intervention of neuropathic pain...
  23. pmc T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity
    Michael Costigan
    UCL Department of Neuroscience, Physiology and Pharmacology and UCL Department of Biochemistry, University College London, London WC1 EBT, United Kingdom
    J Neurosci 29:14415-22. 2009
    ..The neuroimmune interaction following peripheral nerve injury has therefore a substantial adaptive immune component, which is absent or suppressed in the young CNS...
  24. pmc Mechanisms of neuropathic pain
    James N Campbell
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Neuron 52:77-92. 2006
    ..The rapid gain in knowledge about abnormal signaling promises breakthroughs in the treatment of these often debilitating disorders...
  25. pmc Chemokines and the pathophysiology of neuropathic pain
    Fletcher A White
    Department of Cell Biology, Loyola University Chicago, Maywood, IL 60626, USA
    Proc Natl Acad Sci U S A 104:20151-8. 2007
    ....
  26. ncbi Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction
    Petr Dubovy
    Department of Anatomy, Division of Neuroanatomy, Faculty of Medicine and Central European Institute of Technology CEITEC, Masaryk University, Kamenice 3, Brno, Czech Republic
    Ann Anat 193:267-75. 2011
    ..Understanding the pleiotropic effects of cytokines/chemokines, however, requires investigating their highly specific pathways and precise points of action...
  27. ncbi Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing
    Camilla I Svensson
    Department of Anesthesiology, University of California, San Diego, La Jolla, California, USA
    J Neurochem 86:1534-44. 2003
    ..Taken together, these results indicate that spinal p38 MAPK is involved in inflammation-induced pain and that activated spinal microglia play a direct role in spinal nociceptive processing...
  28. ncbi Neuropathic pain: are there distinct subtypes depending on the aetiology or anatomical lesion?
    N Attal
    INSERM U 792, Centre d Evaluation et de Traitement de la Douleur, Hopital Ambroise Pare, APHP, Boulogne Billancourt, F 92100, France
    Pain 138:343-53. 2008
    ..Exceptions included idiopathic trigeminal neuralgia and postherpetic neuralgia...
  29. ncbi Morphine, gabapentin, or their combination for neuropathic pain
    Ian Gilron
    Department of Anesthesiology, Queen s University, Kingston, Ont, Canada
    N Engl J Med 352:1324-34. 2005
    ..We compared the efficacy of a combination of gabapentin and morphine with that of each as a single agent in patients with painful diabetic neuropathy or postherpetic neuralgia.
  30. pmc Pharmacological management of chronic neuropathic pain - consensus statement and guidelines from the Canadian Pain Society
    D E Moulin
    University of Western Ontario, London, Ontario, Canada
    Pain Res Manag 12:13-21. 2007
    ..Further studies are required to examine head-to-head comparisons among analgesics, combinations of analgesics, long-term outcomes, and treatment of pediatric and central NeP...
  31. ncbi Differential activation of spinal microglial and astroglial cells in a mouse model of peripheral neuropathic pain
    Joanna Mika
    Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Eur J Pharmacol 623:65-72. 2009
    ..These findings implicate a glial regulation of the pain response and suggest that pharmacologically targeting microglia could effectively prevent clinical pain syndromes in programmed and/or anticipated injury...
  32. pmc Changes in expression of sensory organ-specific microRNAs in rat dorsal root ganglia in association with mechanical hypersensitivity induced by spinal nerve ligation
    B T Aldrich
    Department of Anesthesia, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA
    Neuroscience 164:711-23. 2009
    ..Moreover, SGs were suggested to be assembled and associated with microRNAs after SNL, which may play a role in modification of microRNA-mediated gene regulation in DRG neurons...
  33. ncbi A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance
    Zhi Ye Zhuang
    Department of Anesthesiology, Pain Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:3551-60. 2006
    ..Targeting the JNK pathway in spinal astroglia may present a new and efficient way to treat neuropathic pain symptoms...
  34. ncbi The roles of sodium channels in nociception: implications for mechanisms of neuropathic pain
    Min Liu
    Wolfson Institute for Biomedical Research, University College, London, UK
    Pain Med 12:S93-9. 2011
    ..Although there is no association between a single sodium channel isoform and neuropathic pain, combined blockade of peripherally expressed isoforms Nav1.7, Nav1.8, and Nav1.9 may prove useful...
  35. ncbi Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain
    Joanna Mika
    Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Cracow, Poland
    Eur J Pharmacol 560:142-9. 2007
    ..These findings indicate that preemptive and repeated administration of glial inhibitors suppresses development of allodynia and hyperalgesia and potentiates effects of morphine in rat and mouse models of neuropathic pain...
  36. ncbi Immune and inflammatory mechanisms in neuropathic pain
    Gila Moalem
    School of Medical Sciences, University of New South Wales, Sydney, Australia
    Brain Res Rev 51:240-64. 2006
    ....
  37. ncbi Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury
    Joachim Scholz
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 25:7317-23. 2005
    ..Preventing nerve injury-induced apoptosis of dorsal horn neurons by blocking caspase activity maintains inhibitory transmission in lamina II and reduces pain hypersensitivity...
  38. pmc T-type voltage-gated calcium channels as targets for the development of novel pain therapies
    Slobodan M Todorovic
    Department of Anesthesiology and Neuroscience, University of Virginia School of Medicine, Charlottesville, 22908 0710, USA
    Br J Pharmacol 163:484-95. 2011
    ..We also discuss possible future developments aimed at selective modulation of function of these channels, which are highly expressed in nociceptors...
  39. ncbi Mechanisms of disease: neuropathic pain--a clinical perspective
    Ralf Baron
    Department of Neurological Pain Research and Therapy, Christian Albrechts Universitat Kiel, Germany
    Nat Clin Pract Neurol 2:95-106. 2006
    ..This review discusses the conceptual framework of the novel mechanism-based classification, encouraging the reader to see neuropathic pain as a clinical entity rather than a compilation of single disease states...
  40. ncbi The role of glia and the immune system in the development and maintenance of neuropathic pain
    Ricardo Vallejo
    Millennium Pain Center, Bloomington, Illinois 61701, USA
    Pain Pract 10:167-84. 2010
    ..Our review focuses on the role of glia and the immune system in the development and maintenance of neuropathic pain...
  41. ncbi P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain
    Kimiko Kobayashi
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    J Neurosci 28:2892-902. 2008
    ..Activation of this receptor by released ATP or the hydrolyzed products activate p38 MAPK pathway and may play a crucial role in the generation of neuropathic pain...
  42. ncbi Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations
    Robert H Dworkin
    Department of Anesthesiology, University of Rochester School of Meedicine and Dentistry, Rochester, NY 14642
    Arch Neurol 60:1524-34. 2003
    ..Continued progress in basic and clinical research on the pathophysiologic mechanisms of neuropathic pain may make it possible to predict effective treatments for individual patients by application of a pain mechanism-based approach...
  43. ncbi Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain
    Guo Gang Xing
    Department of Neurobiology, Key Laboratory for Neuroscience of the Ministry of Education and Public Health, Peking University, 38 Xue Yuan Road, Beijing 100083, People s Republic of China
    Exp Neurol 208:323-32. 2007
    ..LTD of synaptic strength in the spinal dorsal horn in SNL rats may contribute to the long-lasting analgesic effects of EA at 2 Hz...
  44. ncbi Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury
    Bryan C Hains
    Department of Neurology and Paralyzed Veterans of America Eastern Paralyzed Veterans Association Neuroscience Research Center, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 23:8881-92. 2003
    ..3 expression and neuronal hyperexcitability associated with central neuropathic pain...
  45. pmc Chronic neuropathic pain-like behavior correlates with IL-1β expression and disrupts cytokine interactions in the hippocampus
    Adriana del Rey
    Department of Immunophysiology, Institute of Physiology and Pathophysiology, Medical Faculty, 35037 Marburg, Germany
    Pain 152:2827-35. 2011
    ....
  46. pmc Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain
    Xiao peng Mei
    Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi an, PR China
    J Neuroinflammation 8:6. 2011
    ..We hypothesized that inhibition of astrocytic JNK activation might be involved in the suppressive effect of ketamine on SNL-induced spinal astrocytic activation...
  47. ncbi Role of glia in orofacial pain
    Chen Yu Chiang
    Department of Oral Physiology, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    Neuroscientist 17:303-20. 2011
    ....
  48. ncbi Transcriptional and functional profiles of voltage-gated Na(+) channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain
    Temugin Berta
    Department of Anesthesiology, University Hospital Center and University of Lausanne, CH 1011 Lausanne, Switzerland
    Mol Cell Neurosci 37:196-208. 2008
    ..Our results describe altered neuronal electrogenesis following SNI that is likely induced by a complex regulation of VGSCs...
  49. ncbi Statins alleviate experimental nerve injury-induced neuropathic pain
    Xiang Qun Shi
    The Alan Edwards Centre for Research on Pain, McGill University, 740 Dr Penfield Ave, Montreal, Quebec, Canada
    Pain 152:1033-43. 2011
    ..We identified a potential new application of statins in the treatment of neuropathic pain. The pain-alleviating effects of statins are likely attributable to their immunomodulatory effects...
  50. ncbi Peripheral neuropathic pain: from mechanisms to symptoms
    R Baron
    Klinik fur Neurologie, Christian Albrechts Universitat Kiel, Germany
    Clin J Pain 16:S12-20. 2000
    ..These mechanisms can operate in concert in a single disease entity (e.g., postherpetic neuralgia) and also in a single patient. Distinct pathophysiological mechanisms lead to specific sensory symptoms (e.g...
  51. ncbi Similar electrophysiological changes in axotomized and neighboring intact dorsal root ganglion neurons
    Chao Ma
    Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurophysiol 89:1588-602. 2003
    ....
  52. ncbi Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain
    Michael S Gold
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 23:158-66. 2003
    ..These observations suggest that aberrant activity in uninjured C-fibers is a necessary component of pain associated with partial nerve injury. They also suggest that blocking Na(V)1.8 would be an effective treatment of neuropathic pain...
  53. ncbi Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors
    Laiche Djouhri
    Department of Physiology, Medical School, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 26:1281-92. 2006
    ..Overall, SFL was related to SA rate in intact C-nociceptors. Both L5 degeneration and chromic gut cause inflammation. Therefore, both SA and SFL/spontaneous pain after nerve injury (mSNA) may result from cumulative neuroinflammation...
  54. ncbi Psychometric properties of the Medical Outcomes Study Sleep measure
    Ron D Hays
    UCLA Department of Medicine, Division of General Internal Medicine and Health Services Research, 911 Broxton Plaza, Los Angeles, CA 90095 1736, USA
    Sleep Med 6:41-4. 2005
    ..A 12-item self-report sleep measure, the Medical Outcomes Study Sleep measure, was developed and evaluated previously in a sample of 3445 individuals with chronic illness...
  55. ncbi Neuropathic and chronic pain stimuli downregulate central mu-opioid and dopaminergic transmission
    Keiichi Niikura
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Trends Pharmacol Sci 31:299-305. 2010
    ..We also review data on particular gene polymorphisms (e.g. in the mu-receptor gene) that could also influence the relative abuse potential of mu-agonists in clinical pain populations...
  56. ncbi Neuropathic pain: quality-of-life impact, costs and cost effectiveness of therapy
    Alec B O'Connor
    Department of Medicine, University of Rochester School of Medicine and Dentistry, New York, USA
    Pharmacoeconomics 27:95-112. 2009
    ..The most-studied diseases are post-herpetic neuralgia and painful diabetic neuropathy, for which tricyclic antidepressants (both amitriptyline and desipramine) have ..
  57. ncbi The impact of neuropathic pain on health-related quality of life: review and implications
    Mark P Jensen
    Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, WA 98195 6490, USA
    Neurology 68:1178-82. 2007
    ..either the peripheral (postsurgical neuropathic pain associated with breast and amputation surgery, postherpetic neuralgia, and painful diabetic neuropathy) or central (poststroke pain, spinal cord injury pain, multiple sclerosis pain) ..
  58. ncbi Development of a measure of the burden of pain due to herpes zoster and postherpetic neuralgia for prevention trials: adaptation of the brief pain inventory
    Paul M Coplan
    Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Pain 5:344-56. 2004
    ..an HZ-specific questionnaire to quantify HZ pain and discomfort, (2) an operational definition of postherpetic neuralgia (PHN), and (3) a severity-duration measure of the burden of illness caused by HZ...
  59. ncbi The role of spinal neuroimmune activation in morphine tolerance/hyperalgesia in neuropathic and sham-operated rats
    Vasudeva Raghavendra
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosci 22:9980-9. 2002
    ..Targeting central cytokine production and glial activation may improve the effectiveness of morphine and reduce the incidence of morphine withdrawal-induced hyperalgesia and allodynia in neuropathic pain conditions...
  60. ncbi Nociceptor-derived brain-derived neurotrophic factor regulates acute and inflammatory but not neuropathic pain
    Jing Zhao
    Molecular Nociception Group, Department of Biology, University College London, London WC1E 6BT, UK
    Mol Cell Neurosci 31:539-48. 2006
    ..Nociceptor-derived BDNF thus plays an important role in regulating inflammatory pain thresholds and secondary hyperalgesia, but BDNF released only from nociceptors plays no role in the development of neuropathic pain...
  61. ncbi Ectopic discharge in Abeta afferents as a source of neuropathic pain
    Marshall Devor
    Department of Cell and Developmental Biology, Institute of Life Sciences and Center for Research on Pain, Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    Exp Brain Res 196:115-28. 2009
    ..This dual phenotypic switching renders them capable of (1) directly driving postsynaptic pain signaling pathways in the spinal cord, and (2) triggering and maintaining central sensitization...
  62. ncbi Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain
    F Y Tanga
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, HB 7125, One Medical Center Drive, Lebanon, NH 03756, USA
    Neurochem Int 45:397-407. 2004
    ..In summary, these data demonstrate a distinct spinal glial response following nerve injury using real-time RT-PCR...
  63. pmc Differential regulation of immune responses and macrophage/neuron interactions in the dorsal root ganglion in young and adult rats following nerve injury
    David Vega-Avelaira
    Department of Neuroscience, Physiology and Pharmacology, University College of London, Gower Street, London WC1E6BT, UK
    Mol Pain 5:70. 2009
    ....
  64. ncbi Functional biology of the alpha(2)delta subunits of voltage-gated calcium channels
    Anthony Davies
    Laboratory of Cellular and Molecular Neuroscience, Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Trends Pharmacol Sci 28:220-8. 2007
    ....
  65. ncbi Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale
    J T Farrar
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Blockley Hall, Room 816, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Pain 94:149-58. 2001
    ..from 10 recently completed placebo-controlled clinical trials of pregabalin in diabetic neuropathy, postherpetic neuralgia, chronic low back pain, fibromyalgia, and osteoarthritis were used...
  66. ncbi EFNS guidelines on neurostimulation therapy for neuropathic pain
    G Cruccu
    EFNS Panel on Neuropathic Pain, Vienna, Austria
    Eur J Neurol 14:952-70. 2007
    ..These chronically implanted techniques provide satisfactory pain relief in many patients, including those resistant to medication or other means...
  67. ncbi Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation
    Maria Schäfers
    Anesthesiology Research Laboratory, University of California San Diego, La Jolla, California 92093 0818, USA
    J Neurosci 23:3028-38. 2003
    ..We conclude that injured and adjacent uninjured DRG neurons are sensitized to TNF after SNL. Sensitization to endogenous TNF may be essential for the development and maintenance of neuropathic pain...
  68. ncbi Test-retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS): a multi-centre study
    Christian Geber
    Klinik und Poliklinik fur Neurologie, Universitätsmedizin der Johannes Gutenberg Universität, Mainz, Germany
    Pain 152:548-56. 2011
    ....
  69. ncbi Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons
    Marie Pertin
    Anesthesiology Pain Research Group, Department of Anesthesiology, Lausanne University Hospital, CH 1011 Lausanne, Switzerland
    J Neurosci 25:10970-80. 2005
    ....
  70. ncbi Incidence rates and treatment of neuropathic pain conditions in the general population
    Jeanne P Dieleman
    Department of Medical Informatics, Erasmus MC, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Pain 137:681-8. 2008
    ..3 and 2.3 cases/1000 PY followed by diabetic peripheral neuropathy and post-herpetic neuralgia at 0.72 and 0.42/1000 PY...
  71. ncbi Neuropathic pain: emerging treatments
    A Dray
    AstraZeneca Research and Development, 7171 Frederick Banting Street, Montreal, Canada
    Br J Anaesth 101:48-58. 2008
    ..Finally of note is the emergence of biological approaches, for example, antibodies, siRNA, gene therapy, offering powerful therapeutic additions with which to redress the neurological disease imbalances causing neuropathic pain...
  72. ncbi CCL2 is a key mediator of microglia activation in neuropathic pain states
    Michael A Thacker
    Neurorestoration Group, Wolfson Centre for Age Related Diseases, Kings College London, Wolfson Wing, Hodgkin Building, Guy s Campus, London, London, UK
    Eur J Pain 13:263-72. 2009
    ..Thus, the neuronal expression of CCL2 provides a mechanism for immune activation, which in turn regulates the sensitivity of pain signaling systems in neuropathic pain states...
  73. ncbi The up-regulation of IL-6 in DRG and spinal dorsal horn contributes to neuropathic pain following L5 ventral root transection
    Xu Hong Wei
    Pain Research Center and Department of Physiology, Zhongshan Medical School of Sun Yat Sen University, PR China
    Exp Neurol 241:159-68. 2013
    ..These data suggested that the increased IL-6 in afferent neurons and spinal cord contribute to the development of neuropathic pain following motor fiber injury, and that TNF-α is responsible for the up-regulation of IL-6...
  74. pmc Characterization of bilateral trigeminal constriction injury using an operant facial pain assay
    H L Rossi
    College of Dentistry Department of Orthodontics, University of Florida, Gainesville, FL, United States
    Neuroscience 224:294-306. 2012
    ..Understanding this relationship will allow us to better treat and prevent chronic neuropathic pain...
  75. ncbi T lymphocytes containing β-endorphin ameliorate mechanical hypersensitivity following nerve injury
    Dominika Labuz
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Krahmerstrasse 6, Berlin, Germany
    Brain Behav Immun 24:1045-53. 2010
    ..Our findings reveal β-endorphin-containing T cells as a crucial component of beneficial adaptive immune responses associated with painful peripheral nerve injuries...
  76. pmc Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain
    Milena De Felice
    Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Pain 152:2701-9. 2011
    ..Engagement of descending inhibition protects in the transition from acute to chronic pain. These unexpected findings might provide a mechanistic explanation for medications that engage descending inhibition or mimic its consequences...
  77. pmc The persistent release of HMGB1 contributes to tactile hyperalgesia in a rodent model of neuropathic pain
    Polina Feldman
    Program in Medical Neurosciences, Paul and Carole Stark Neurosciences Research Institute, Indiana University, School of Medicine, 950 West Walnut Street, Indianapolis, IN 46202, USA
    J Neuroinflammation 9:180. 2012
    ..The present study investigated the degree to which HMGB1 signaling contributes to the maintenance of neuropathic pain behavior in the rodent...
  78. pmc Origins, actions and dynamic expression patterns of the neuropeptide VGF in rat peripheral and central sensory neurones following peripheral nerve injury
    Andrew Moss
    UCL Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    Mol Pain 4:62. 2008
    ....
  79. ncbi Pain, medication use, and health-related quality of life in older persons with postherpetic neuralgia: results from a population-based survey
    Gerry Oster
    Policy Analysis Inc, Brookline, Massachusetts 02445, USA
    J Pain 6:356-63. 2005
    Persons aged >65 years with pain caused by postherpetic neuralgia (PHN) were recruited via advertisements in 24 US newspapers and were mailed a questionnaire that addressed pain intensity (average, worst, least, current), pain ..
  80. ncbi The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain
    S Abdi
    Department of Anesthesiology and Critical Care, The Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Anesth Analg 87:1360-6. 1998
    ..Finally, the site of action of LDC seems to be primarily in the periphery, and that of GBP is exclusively central, whereas that of AMI seems to have both peripheral and central components...
  81. ncbi Epidemiology of neuropathic pain and its impact on quality of life
    Blair H Smith
    University of Dundee, Medical Research Institute, Kirsty Semple Way, Dundee, Scotland, UK
    Curr Pain Headache Rep 16:191-8. 2012
    ..All neuropathic pain is associated with poor general health, comparable with other severe chronic diseases. The importance of newly proposed risk factors, including genetic factors, still needs to be assessed at a population level...
  82. ncbi Induction of CX3CL1 expression in astrocytes and CX3CR1 in microglia in the spinal cord of a rat model of neuropathic pain
    Jill A Lindia
    Department of Pharmacology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Pain 6:434-8. 2005
    ..However, after spinal nerve injury, CX3CR1-LI was upregulated in microglia throughout the dorsal horn...
  83. ncbi Ketamine depresses toll-like receptor 3 signaling in spinal microglia in a rat model of neuropathic pain
    Xiao peng Mei
    Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi an, PR China
    Neurosignals 19:44-53. 2011
    ....
  84. ncbi Prostaglandin E2 and pain--an update
    Atsufumi Kawabata
    Division of Pharmacology and Pathophysiology, School of Pharmacy, Kinki University, Higashi Osaka 577 8502, Japan
    Biol Pharm Bull 34:1170-3. 2011
    ..Thus, PGE(2) has a great impact on pain signals, and pharmacological intervention in upstream and downstream signals of PGE(2) may serve as novel therapeutic strategies for the treatment of intractable pain...
  85. ncbi An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients
    Petra Schweinhardt
    Department of Human Anatomy and Genetics, Oxford University, South Parks Road, Oxford OX1 1QX, UK
    Neuroimage 32:256-65. 2006
    ..Taken together, our data and the literature review suggest a functional segregation of anterior insular cortex...
  86. ncbi ARA290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain: an experimental study in rats and β-common receptor knockout mice
    Maarten Swartjes
    Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands
    Anesthesiology 115:1084-92. 2011
    ....
  87. ncbi Epigenetic augmentation of the macrophage inflammatory protein 2/C-X-C chemokine receptor type 2 axis through histone H3 acetylation in injured peripheral nerves elicits neuropathic pain
    Norikazu Kiguchi
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, Wakayama 641 0012, Japan
    J Pharmacol Exp Ther 340:577-87. 2012
    ....
  88. ncbi Resident glial cell activation in response to perispinal inflammation leads to acute changes in nociceptive sensitivity: implications for the generation of neuropathic pain
    Gustavo Tenorio
    Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Alberta, Canada
    Pain 154:71-81. 2013
    ..Our findings suggest that the chronicity of pain after injury or disease in the nervous system is dependent on the integrity of the BBB/BSCB...
  89. pmc GABA and central neuropathic pain following spinal cord injury
    Young S Gwak
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1043, USA
    Neuropharmacology 60:799-808. 2011
    ..This article is part of a Special Issue entitled 'Synaptic Plasticity & Interneurons'...
  90. ncbi Motor cortex rTMS restores defective intracortical inhibition in chronic neuropathic pain
    J P Lefaucheur
    Department of Physiology, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, INSERM U 421, IM3 Faculté de Médecine de Créteil, Creteil, France
    Neurology 67:1568-74. 2006
    ..To assess cortical excitability changes in patients with chronic neuropathic pain at baseline and after repetitive transcranial magnetic stimulation (rTMS) of the motor cortex...
  91. pmc Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models
    W Xie
    Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0531, USA
    Neuroscience 160:847-57. 2009
    ..The results indicate that early spontaneous activity in injured sensory neurons may play important roles in glia activation and pathological pain...
  92. pmc Evidence that spinal astrocytes but not microglia contribute to the pathogenesis of Paclitaxel-induced painful neuropathy
    Haijun Zhang
    Department of Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Pain 13:293-303. 2012
    ..These data suggest the involvement of spinal astrocytes but not microglia in the pathogenesis of paclitaxel-induced neuropathy...
  93. ncbi Systemic absorption of topical lidocaine in normal volunteers, patients with post-herpetic neuralgia, and patients with acute herpes zoster
    Bryan J Campbell
    Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Pharm Sci 91:1343-50. 2002
    Topical lidocaine has been recently marketed as a new treatment for post-herpetic neuralgia. The aim of our study was to characterize the absorption profile of and systemic exposure to lidocaine from patch and gel formulations in normal ..
  94. ncbi Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy
    B Shim
    Brain Research Institute, Brain Korea 21 Project for Medical Science, and Department of Physiology, Yonsei University College of Medicine, C P O Box 8044, 120 752, Seoul, South Korea
    Neuroscience 132:193-201. 2005
    ..This nociceptor sensitization can contribute to neuropathic pain...
  95. ncbi Initial characterization of the transplant of immortalized chromaffin cells for the attenuation of chronic neuropathic pain
    M J Eaton
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, FL 33136, USA
    Cell Transplant 9:637-56. 2000
    ..The use of such chromaffin cell lines that are able to deliver antinociceptive molecules in models of chronic pain after nerve and spinal cord injury (SCI) offers a novel approach to pain management...
  96. pmc Colocalized structural and functional changes in the cortex of patients with trigeminal neuropathic pain
    Alexandre F DaSilva
    PAIN Group, Brain Imaging Center, McLean Hospital, Harvard Medical School, Boston, MA, USA
    PLoS ONE 3:e3396. 2008
    ..The model has a number of advantages including the evaluation of specific changes that can be mapped to known somatotopic anatomy...
  97. ncbi Quantitative sensory testing: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
    M E Shy
    Department of Neurology and Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA
    Neurology 60:898-904. 2003
    ..This assessment evaluates the clinical utility, efficacy, and safety of quantitative sensory testing (QST)...
  98. ncbi Pain and sensory complaints in multiple sclerosis
    A G Beiske
    Department of Neurology, Akershus University Hospital, Nordbyhagen, Norway
    Eur J Neurol 11:479-82. 2004
    ..The most frequently reported characteristics of the symptoms were paresthesia, neuralgia and deep muscular aching...
  99. ncbi Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy
    Sarah J L Flatters
    Anaesthesia Research Unit, McIntyre Building, Room 1213, McGill University, 3655 Promenade Sir William Osler, Montreal, QC, Canada H3G 1Y6
    Pain 109:150-61. 2004
    ..These data suggest that T-type calcium channels may play a role in chemotherapy-induced neuropathy and moreover identify ethosuximide as a new potential treatment for chemotherapy-induced pain...
  100. ncbi Case control series of intrathecal autologous bone marrow mesenchymal stem cell therapy for chronic spinal cord injury
    Nirmeen A Kishk
    Department of Neurology, Cairo University, Cairo, Egypt
    Neurorehabil Neural Repair 24:702-8. 2010
    ..Autologous bone marrow mesenchymal cells that include stem cells (MSCs) are a clinically attractive cellular therapy option to try to treat severe spinal cord injury (SCI)...
  101. pmc Spinal nerve ligation in mouse upregulates TRPV1 heat function in injured IB4-positive nociceptors
    Daniel Vilceanu
    Department of Cell Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
    J Pain 11:588-99. 2010
    ..Also, SNL had no effect on heat responses in medium-large-diameter neurons from either the injured or adjacent ganglia...

Research Grants65

  1. NEUROBIOLOGY OF VARICELLA ZOSTER VIRUS
    Donald Gilden; Fiscal Year: 2013
    ..Zoster is often followed by postherpetic neuralgia (PHN, chronic pain), as well as retinitis, myelitis and vasculopathy, which are significant causes of blindness, ..
  2. Mechanisms by which VZV IE proteins interact with cell antiviral proteins to prev
    MARIA ACENA NAGEL; Fiscal Year: 2013
    ..serious neurological diseases including zoster (shingles) frequently complicated by chronic pain (postherpetic neuralgia), stroke, blindness and spinal cord disease...
  3. Varicella zoster virus-Induced Pain in a Rat Model of Post-Herpetic Neuralgia
    Paul R Kinchington; Fiscal Year: 2013
    Post-Herpetic Neuralgia (PHN) is a common and exceedingly painful complication of herpes zoster that is debilitating, intractable, long-lasting and difficult to treat...
  4. Prevention of VZV Reactivation
    Randall J Cohrs; Fiscal Year: 2013
    ..reactivation, mostly in elderly and immunocompromised individuals, causes zoster, often followed by postherpetic neuralgia, myelitis, meningoencephalitis, vasculopathy and ocular diseases...
  5. The Role of Semaphorins in Axon and Blood Vessel Guidance
    Chenghua Gu; Fiscal Year: 2013
    ..therapy, and prevention of several neurological diseases, including diabetic neuropathy and trigeminal neuralgia. Moreover, emerging evidence shows some neurodegenerative diseases, such as Alzheimer's disease, ..
  6. Integration of Immunochemical, Genomic & Transcriptomic Analyses of Human Skin
    FRANK LAMBERT contact RICE; Fiscal Year: 2010
    ..Biopsies from normal humans and patients with postherpetic neuralgia, will be compared by using alternating sections for immunofluorescence and genomic and transcriptomic arrays...
  7. The molecular pathogenesis of varicella zoster virus infection
    Donald Gilden; Fiscal Year: 2013
    ..Zoster is frequently complicated by chronic pain (postherpetic neuralgia), as well as paralysis, blindness and stroke. Currently, ~1,000,000 Americans develop zoster annually...
  8. MECHANISM OF NOCICEPTION INDUCED BY INNOCUOUS COLD IN TRIGEMINAL SYSTEM
    Jianguo Gu; Fiscal Year: 2012
    Orofacial pain disorders encompass a wide range of conditions including trigeminal neuralgia, reflex sympathetic dystrophy (RSD) of the face, temporomandibular joint disorders, periodontal pain, burning mouth syndrome, dental surgical ..
  9. Pathophysiology and diagnosis of neurological pain syndromes
    Anne Louise Oaklander; Fiscal Year: 2012
    ..Her long-term career goals are to identify and investigate neuropathic pain (neuralgia) syndromes, and to develop better objective methods for diagnosing and studying them...
  10. CA8 Variants: New Mechanisms Underlying Transitions to Persistent Pain Syndromes
    Eden R Martin; Fiscal Year: 2013
    ..pain syndromes including temporomandibular disease (TMD), TMD with widespread pain, sciatica, post-herpetic neuralgia (PHN), neuropathic pain after spinal cord injury (SCI), and osteoarthritis (OA)...
  11. A new in vitro neuron model of axonal transport and persistence of varicella zost
    Paul R Kinchington; Fiscal Year: 2013
    ..still result upwards of half as million zoster cases annually and some 50,000 cases of severe post herpetic neuralgia. We know little of the parameters affecting VZV axonal transport and the latent state, because most animal ..
  12. Civamide Nasal Spray for the Treatment of Postherpetic Neuralgia of the Trigemina
    Scott B Phillips; Fiscal Year: 2013
    ..project is the initial proof of concept clinical study of Civamide Nasal Spray for the treatment of postherpetic neuralgia (PHN) of the trigeminal nerve [(TN), a severely disabling facial pain syndrome]...
  13. Zoster Vaccine and Risk Factors of Zoster and Post-Herpetic Neuralgia
    HUNGFU TSENG; Fiscal Year: 2013
    ..Because zoster and its attendant neurologic complication of postherpetic neuralgia (PHN) are common and serious among the elderly, it seems prudent to recommend zoster vaccine...
  14. Impact of immune senescence on herpes zoster in a nonhuman primate model
    Ilhem Messaoudi; Fiscal Year: 2013
    ..Advanced age is the primary risk factor not only for developing HZ, but also complications such as post herpetic neuralgia, vasculopathies and zoster opthalmicus...
  15. Molecular regulation of trigeminal sensory ganglia development
    Holger Knaut; Fiscal Year: 2013
    ..Malformations or injuries of the trigeminal sensory ganglion are associated with neuralgia, a recurrent facial pain condition...
  16. Synthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic Pain
    James M Cook; Fiscal Year: 2013
    ..pain encompasses a range of painful conditions of diverse origins including diabetic neuropathy, post-herpetic neuralgia and nerve injuries after surgery...
  17. Autophagy and ER stress during varicella infection
    CHARLES F GROSE; Fiscal Year: 2013
    ..The results are relevant not only to our understanding of varicella vaccination but also the debilitating zoster-related illness called post-herpetic neuralgia.
  18. Remark bundle structure and function in neuropathic pain
    John W Griffin; Fiscal Year: 2010
    ..The proposed data will have implications for understanding and treating not just pain in partial nerve injuries, but painful neuropathies such as diabetes, causalgia, and postherpetic neuralgia.
  19. Capsaicin-sensitive primary afferent fibers and neuropathic pain
    JENNIFER LYNN GIBBS; Fiscal Year: 2013
    ..afferent neurons in mediating NP by performing a cross-sectional study on subjects diagnosed with post- herpetic neuralgia (PHN) and a complementary series of studies in animals using a model of orofacial NP...
  20. Genes for human chronic pain syndromes through whole genome sequencing
    Kari Stefansson; Fiscal Year: 2013
    ..gabapentin or pregabalin for common chronic pain syndromes including diabetic neuropathy and post-herpetic neuralgia. The extra phenotyping will give us additional dimensions beyond the basic pain symptomology including quality ..
  21. ANTIGENIC DETERMINANTS OF VARICELLA VIRUS
    Charles Grose; Fiscal Year: 2006
    ..VZV infection is a recurrent problem in both transplant and cancer patients. Herpes zoster and post herpetic neuralgia are also major medical problems in the elderly population. The VZV genome encodes about 70 open reading frames...
  22. TMS Effects on Pain Perception
    Jeffrey J Borckardt; Fiscal Year: 2010
    ..4) Determine if findings from the laboratory investigations generalize to patients with trigeminal neuralgia. Building on the candidate's knowledge base in clinical psychology, statistics, psychophysiology and ..
  23. 26th Intl Herpesvirus Workshop, Regensburg, Germany
    Jay Nelson; Fiscal Year: 2001
    ..Shingles and post-herpetic neuralgia are problems in the elderly...
  24. International Herpesvirus Workshop, Cairns, Australia
    Jay Nelson; Fiscal Year: 2002
    ..Shingles and post-herpetic neuralgia are problems in the elderly...
  25. 25TH INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay Nelson; Fiscal Year: 2000
    ..Shingles and post-herpetic neuralgia are problems in the elderly...
  26. Morphogenesis of the peripheral sensory nervous system
    MARK VOIGT; Fiscal Year: 2009
    ..g. peripheral neuropathies arising from diabetes, HIV/AIDS and herpes, trigeminal neuralgia, the various hereditary sensory neuropathies, neuropathies arising from trauma or surgical outcomes, and others...
  27. 24TH INTERNATIONAL HERPESVIRUS WORKSHOP
    Frederick Wang; Fiscal Year: 1999
    ..Shingles and post-herpetic neuralgia are problems in the elderly...
  28. DEFINITION OF THE CHRONIC EPSTEIN-BARR VIRUS SYNDROME
    James Jones; Fiscal Year: 1990
    ..who have had varying combinations of pharyngitis, lymphadenopathy, headache, fatigue, myalgia, arthralgia, neuralgia, paresthesis, depression and dyslogia for over two years, and four controls--unrelated individuals but age- and ..
  29. Trigeminal Neuropathic Pain Mechanisms
    Michael Henry; Fiscal Year: 2006
    ..Trigeminal neuralgia may result from a root entry zone injury, while peripheral trigeminal neuropathy follows damage to peripheral ..
  30. Recombinant Herpes Injection into Trigeminal Ganglia
    David Yeomans; Fiscal Year: 2004
    Head cancer pain, trigeminal neuralgia, migraine headache, dental pain and temporomandibular joint pain are all examples of pain syndromes that are unique to the trigeminal system...
  31. MOLECULAR GENETICS OF SENSORY GANGLIA DEVELOPMENT
    Alexander Schier; Fiscal Year: 2007
    ..of the trigeminal nerve are clinically and cosmetically devastating and are often associated with trigeminal neuralgia, a severe and recurrent neuropathic facial pain syndrome...
  32. Novel Operant Thermal Assessments of Orofacial Pain
    JOHN NEUBERT; Fiscal Year: 2007
    ..Orofacial pain encompasses a multitude of disorders, including temporomandibular disorders (TMD), trigeminal neuralgia, headaches (e.g., migraine, tension-type), and myofascial pain, and affects an estimated 20% of the U.S...
  33. AGE-RELATED CHANGE IN TRIGEMINAL GANGLION EXCITABILITY
    Thomas Baumann; Fiscal Year: 2003
    Age is a risk factor for neuropathic pain such as trigeminal neuralgia. Trigeminal neuralgia is a severe, recurrent (episodic, but otherwise chronic) neuropathic facial pain syndrome that is rarely observed in children or young adults...
  34. Chronic Compression of the Trigeminal Ganglia
    David Yeomans; Fiscal Year: 2009
    Trigeminal neuralgia (tic douloureux) is a devistatingly painful craniofacial disease, characterized by intense stabbing pains of the face which may be elicited by light touch...
  35. NEUROPHARMACOLOGY OF THE TRIGEMINAL NUCLEUS
    GERHARD FROMM; Fiscal Year: 1992
    Carbamazepine has become the drug of choice in the treatment of trigeminal neuralgia. However, it can have significant side effects as well as not being effective in some cases...
  36. Joint Initiative in Vaccine Economics (JIVE) Project
    Tracy Lieu; Fiscal Year: 2007
    ..interviews with two subgroups: (1) Recent-zoster patients - adults who have recently had zoster or post-herpetic neuralgia; and (2) Community representatives - adults selected at random from health plan populations...
  37. OROFACIAL PAIN RESEARCH CENTER
    Glenn Clark; Fiscal Year: 1990
    ..of two commonly used medications (antidepressants and neuroleptics for the treatment of chronic post-herpetic neuralgia. The other is a study involving the assessment of various psychological factors as a method of predicting which ..
  38. APPROACHES TO GELSEMIUM ALKALOIDS: SYNTHESIS OF KOUMINE
    JAMES DITTAMI; Fiscal Year: 1991
    ..These compounds have a long history of use as analgesics in the treatment of neuralgia and migraine...
  39. EFFECT OF UNTRAOCULAR GRAFTING ON THE CORNEA
    Lawrence Borges; Fiscal Year: 1992
    ..procedures and percutaneous radiofrequency lesions directed at alleviating the intense pain of trigeminal neuralgia. These procedures are directed at destroying trigeminal ganglion cells or transecting the fifth cranial nerve...
  40. Animal models to design & evaluate improved VZV vaccines
    WAYNE GRAY; Fiscal Year: 2007
    ..The virus may reactivate later in life to cause herpes zoster (shingles) and postherpetic neuralgia. VZV infections cause significant morbidity, especially in children, the elderly, and immunosuppressed patients...
  41. Novel Topical Treatment for Postherpetic Neuralgia
    Charles Gauntt; Fiscal Year: 2005
    The goal of this project is to develop a novel topical drug delivery vehicle to treat postherpetic neuralgia [PHN). PHN is defined as pain in the affected dermatome that persists or appears after the rash of herpes zoster (HZ) has healed...
  42. ROCHESTER NEUROEPIDEMIOLOGY PROGRAM PROJECT
    LEONARD KURLAND; Fiscal Year: 1991
    ..descriptive data for mental retardation, cervical radiculopathy, brain injury, trigeminal and glossopharyngeal neuralgia, and childhood spinal muscular atrophy...
  43. POSTMORTEM STUDIES OF PAINFUL PERIPHERAL NEUROPATHY
    VIRGINIA SEYBOLD; Fiscal Year: 1991
    ..g., post- herpetic neuralgia and diabetic neuralgia)...
  44. Trigeminal Neuralgia Association 5th National Conference
    Albert Rhoton; Fiscal Year: 2005
    The Trigeminal Neuralgia Association Fifth National Conference will be held November 11-14, 2004 at the Hilton in the Walt Disney World Resort, Orlando, Florida...
  45. Fourth International Conference--Varicella Zoster Virus
    Anne Gershon; Fiscal Year: 2001
    ..severe pain that may persist for months to years after the original illness, a condition termed post herpetic neuralgia (PHN)...
  46. Analgesia in Herpes Zoster and Postherpetic Neuralgia
    Robert Dworkin; Fiscal Year: 2001
    ..Herpes zoster pain that persists after healing of the acute infection is termed postherpetic neuralgia (PHN), a chronic pain syndrome that is often refractory to all treatment...
  47. PAIN & NEURAL DYSFUNCTION FROM ACUTE HERPES ZOSTER
    Karin Petersen; Fiscal Year: 2003
    ..with AHZ recover uneventfully, but a minority develop enduring neuropathic pain - in the form of post-herpetic neuralgia (PHN)...
  48. VARICELLA ZOSTER VIRUS PATHOGENESIS
    John Hay; Fiscal Year: 2000
    ..for VZV and are thus candidates for zoster and its attendant frequent, serious complication, post-herpetic neuralgia. At present, we have little hard information on the pathogenesis and lifestyle of this important human virus...
  49. NOVEL SODIUM CHANNEL ANTAGONISTS FOR NEUROPATHIC PAIN
    VICTOR ILYIN; Fiscal Year: 1999
    ..The condition includes syndromes as diverse as diabetic neuropathy, cancer neuropathy, and trigeminal neuralgia. Neuropathic pain is largely resistant to treatment by current therapies. In the U.S...
  50. GENE REGULATION BY VARICELLA ZOSTER VIRUS 140K. PROTEIN
    JOAN BETZ; Fiscal Year: 1992
    ..A common complication of zoster, especially in the elderly, is post-herpetic neuralgia, characterized by dermatomal pain persisting for months or years following the zoster rash...
  51. EGFP-Tagged VZV for the Study of Neuronal Infection
    THOMAS HEINEMAN; Fiscal Year: 2006
    ..of shingles patients develop long-lasting, severe pain at the site of the rash referred to postherpetic neuralgia (PHN)...
  52. OPIOID AND NONOPIOID MECHANISM(S) OF NEUROPATHIC PAIN
    Yuri Kolesnikov; Fiscal Year: 2001
    ..with peripheral neuropathies such as those associated with HIV infection and diabetes, as well as post herpetic neuralgia. In cancer patients, neuropathic pain often follows compression or infiltration of nerves by tumors...
  53. Neurite density in skin as a marker for neuropathic pain
    Anne Louise Oaklander; Fiscal Year: 2005
    ..the usefulness of these methods in adults with one of two common neuropathic pain conditions, postherpetic neuralgia (PHN) after shingles (herpes zoster), or painful neuropathy in the lower legs from diabetes mellitus, and in rat ..
  54. Herpes Zoster and Medications in the Elderly
    Kenneth Schmader; Fiscal Year: 2005
    ..The objectives of his zoster research program are the optimal management of zoster and postherpetic neuralgia in the elderly...
  55. MIDCAREER INVESTIGATOR AWARD IN NEURO-AIDS RESEARCH
    David Simpson; Fiscal Year: 2005
    ..The Neuro-Adherence Program will assess the affect of neurological disease on patients' adherence to medical regimens, and the impact of education and support groups on adherence. ..
  56. Mechanisms of chemotherapy-evoked neuropathic pain
    Gary Bennett; Fiscal Year: 2009
    ....
  57. Anesthetics block neuronal voltage-gated Ca2+ currents
    SLOBODAN TODOROVIC; Fiscal Year: 2009
    ..abstract_text> ..
  58. MULTIPLE CLASSES OF CA2+ CHANNELS - SENSORY TRANSMISSION
    SLOBODAN TODOROVIC; Fiscal Year: 2004
    ..abstract_text> ..
  59. REDOX PHARMACOLOGY OF T CHANNELS IN DRG NEURONS
    SLOBODAN TODOROVIC; Fiscal Year: 2009
    ..In addition, our results suggest an unexplored avenue for the development of potential novel therapies for pain control. ..
  60. NEUROPATHIC PAIN FROM AN EXPERIMENTAL NEURITIS
    Gary Bennett; Fiscal Year: 2002
    ..Electrophysiological recordings from identified sensory axons will determine if abnormal discharge arises at the site of inflammation and if there is peripheral sensitization due to an antidromically-conducted ectopic discharge. ..
  61. CHRONIC NEUROPATHIC PAIN MECHANISMS AND MANAGEMENT
    Michael Rowbotham; Fiscal Year: 2004
    ..Project II will test the hypothesis that development of chronic post-herpetic neuralgia after herpes zoster strongly depends on the severity of the initial neural injury and the quality of neural ..
  62. Cellular Mechanisms of Hyperalgesia and Opioid Tolerance
    Jianren Mao; Fiscal Year: 2005
    ....
  63. Rehabilitation of Spinal Cord Injury-Related Pain
    Mark Jensen; Fiscal Year: 2006
    ..abstract_text> ..