intractable pain

Summary

Summary: Persistent pain that is refractory to some or all forms of treatment.

Top Publications

  1. ncbi Acute, chronic, and cancer pain. Clinical management
    Allen W Burton
    Section of Cancer Pain Management, Department of Anesthesiology, Division of Anesthesiology and Critical Care University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Methods Mol Med 84:267-83. 2003
  2. ncbi Stereotactic bilateral anterior cingulotomy for intractable pain
    Chun Po Yen
    Department of Neurosurgery, Kaohsiung Medical University Hospital, Taiwan
    J Clin Neurosci 12:886-90. 2005
  3. ncbi A comparison of two invasive techniques in the management of intractable pain due to inoperable pancreatic cancer: neurolytic celiac plexus block and videothoracoscopic splanchnicectomy
    T Stefaniak
    Department of General, Endocrine and Transplant Surgery, Medical University of Gdansk, 1 Debinki Street, PL 80 211 Gdansk, Poland
    Eur J Surg Oncol 31:768-73. 2005
  4. ncbi Descending control of persistent pain: inhibitory or facilitatory?
    Horacio Vanegas
    Instituto Venezolano de Investigaciones Cientificas IVIC, Apartado 21827, Caracas 1020A, Venezuela
    Brain Res Brain Res Rev 46:295-309. 2004
  5. ncbi Videothoracoscopic splanchnicectomy for intractable pain from adrenal metastasis
    Loic Lang-Lazdunski
    Department of Thoracic Surgery, Hopital Europeen Georges Pompidou, Paris, France
    Ann Thorac Surg 73:1290-2. 2002
  6. ncbi Impact of bilateral anterior cingulotomy on neurocognitive function in patients with intractable pain
    Chun Po Yen
    Department of Neurosurgery, Kaohsiung Medical University, 100 Shih Chuang 1st Road, Kaohsiung 807, Taiwan
    J Clin Neurosci 16:214-9. 2009
  7. ncbi Intrathecal opioids for intractable pain syndromes
    A Koulousakis
    Department of Neurosurgery, Cologne University, Cologne, Germany
    Acta Neurochir Suppl 97:43-8. 2007
  8. ncbi Long term follow-up results of dorsal root entry zone lesions for intractable pain after brachial plexus avulsion injuries
    H J Chen
    Department of Neurosurgery and Orthopedics, E Da Hospital and I Shou University, Kaohsiung Hsien, Taiwan
    Acta Neurochir Suppl 99:73-5. 2006
  9. ncbi Deep brain stimulation for the treatment of chronic, intractable pain
    Bradley A Wallace
    Department of Neurosurgery, University of Florida, Gainesville 32610, USA
    Neurosurg Clin N Am 15:343-57, vii. 2004
  10. ncbi Motor cortex stimulation for intractable pain
    Richard K Osenbach
    Division of Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neurosurg Focus 21:E7. 2006

Research Grants

Detail Information

Publications247 found, 100 shown here

  1. ncbi Acute, chronic, and cancer pain. Clinical management
    Allen W Burton
    Section of Cancer Pain Management, Department of Anesthesiology, Division of Anesthesiology and Critical Care University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Methods Mol Med 84:267-83. 2003
  2. ncbi Stereotactic bilateral anterior cingulotomy for intractable pain
    Chun Po Yen
    Department of Neurosurgery, Kaohsiung Medical University Hospital, Taiwan
    J Clin Neurosci 12:886-90. 2005
    To document the value of cingulotomy for pain relief, a series of 22 patients with medically intractable pain, including 15 with cancer pain and seven with non-cancer pain, underwent stereotactic bilateral anterior cingulotomy, between ..
  3. ncbi A comparison of two invasive techniques in the management of intractable pain due to inoperable pancreatic cancer: neurolytic celiac plexus block and videothoracoscopic splanchnicectomy
    T Stefaniak
    Department of General, Endocrine and Transplant Surgery, Medical University of Gdansk, 1 Debinki Street, PL 80 211 Gdansk, Poland
    Eur J Surg Oncol 31:768-73. 2005
    ....
  4. ncbi Descending control of persistent pain: inhibitory or facilitatory?
    Horacio Vanegas
    Instituto Venezolano de Investigaciones Cientificas IVIC, Apartado 21827, Caracas 1020A, Venezuela
    Brain Res Brain Res Rev 46:295-309. 2004
    ..Therapies that enhance descending inhibition and/or attenuate descending facilitation are furthermore an important target for research in the future...
  5. ncbi Videothoracoscopic splanchnicectomy for intractable pain from adrenal metastasis
    Loic Lang-Lazdunski
    Department of Thoracic Surgery, Hopital Europeen Georges Pompidou, Paris, France
    Ann Thorac Surg 73:1290-2. 2002
    ..of a videothoracoscopic left splanchnicectomy in a patient with a previous right pneumonectomy who suffered intractable pain from an irresectable left adrenal metastasis associated with metastatic retroperitoneal lymph nodes...
  6. ncbi Impact of bilateral anterior cingulotomy on neurocognitive function in patients with intractable pain
    Chun Po Yen
    Department of Neurosurgery, Kaohsiung Medical University, 100 Shih Chuang 1st Road, Kaohsiung 807, Taiwan
    J Clin Neurosci 16:214-9. 2009
    ..A decline in focused attention performance was identified at the early post-operative assessment. The results of this longitudinal evaluation will help to better define the risk-to-benefit profile of cingulotomy for intractable pain.
  7. ncbi Intrathecal opioids for intractable pain syndromes
    A Koulousakis
    Department of Neurosurgery, Cologne University, Cologne, Germany
    Acta Neurochir Suppl 97:43-8. 2007
    ..Pumps for chronic intrathecal opioid application should only be implanted in specialized centers...
  8. ncbi Long term follow-up results of dorsal root entry zone lesions for intractable pain after brachial plexus avulsion injuries
    H J Chen
    Department of Neurosurgery and Orthopedics, E Da Hospital and I Shou University, Kaohsiung Hsien, Taiwan
    Acta Neurochir Suppl 99:73-5. 2006
    ..b>Intractable pain and paralysis of the affected limbs are the major neurological deficits...
  9. ncbi Deep brain stimulation for the treatment of chronic, intractable pain
    Bradley A Wallace
    Department of Neurosurgery, University of Florida, Gainesville 32610, USA
    Neurosurg Clin N Am 15:343-57, vii. 2004
    ....
  10. ncbi Motor cortex stimulation for intractable pain
    Richard K Osenbach
    Division of Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neurosurg Focus 21:E7. 2006
    ..It is also possible that with the use of noninvasive tools such as transcranial magnetic stimulation, practitioners will be able to predict with accuracy which patients are likely to respond favorably to MCS...
  11. ncbi Deep brain stimulation for the treatment of intractable pain
    Robert M Levy
    Departments of Neurological Surgery and Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Neurosurg Clin N Am 14:389-99, vi. 2003
    ....
  12. ncbi Percutaneous vertebroplasty in patients with intractable pain from osteoporotic or metastatic fractures: A prospective study using quality-of-life assessment
    Gordon Cheung
    Bone Metastases Clinic, Toronto Sunnybrook Regional Cancer Centre, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, ON
    Can Assoc Radiol J 57:13-21. 2006
    ..We prospectively evaluate the efficacy of PVP in the relief of pain and improvement in quality of life of patients with intractable pain from osteoporotic and metastatic fractures.
  13. ncbi Neurosurgical treatments of intractable pain
    Stylianos Nicolaidis
    College de France, Paris, France
    Metabolism 59:S27-31. 2010
    b>Intractable pain may require neurosurgical intervention. This review provides a critical update of neurosurgical techniques available to treat this condition...
  14. ncbi SB366791, a TRPV1 antagonist, potentiates analgesic effects of systemic morphine in a murine model of bone cancer pain
    Y Niiyama
    Department of Anaesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    Br J Anaesth 102:251-8. 2009
    ..In this study, we examined the analgesic effects of the combination of a transient receptor potential vanilloid subfamily 1 (TRPV1) antagonist and morphine on pain-related behaviours in a murine model of bone cancer pain...
  15. ncbi Intrathecal narcotic infusion pumps for intractable pain of chronic pancreatitis: a pilot series
    Pradermchai Kongkam
    Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Am J Gastroenterol 104:1249-55. 2009
    ..ITNP offers the advantages of reversibility, lower total narcotic dose, and the pancreas remaining intact...
  16. ncbi Transdermal buprenorphine
    Hannah C Evans
    Adis International Limited, Mairangi Bay, Auckland, New Zealand
    Drugs 63:1999-2010; discussion 2011-2. 2003
    ..Transdermal buprenorphine was generally well tolerated. Systemic adverse events were typical of opioid treatment or were attributable to the underlying disease...
  17. ncbi [Chronic intrathecal drug administration for the control of intractable pain]
    Takaomi Taira
    Department of Neurosurgery, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Brain Nerve 60:509-17. 2008
    Intrathecal drug administration for the control of intractable pain has been practiced over many years in various countries; however, because of government regulation, no drugs except baclofen are approved for chronic intrathecal use in ..
  18. pmc Sex differences in endogenous pain modulation by distracting and painful conditioning stimulation
    Raimi L Quiton
    Program in Neuroscience, Department of Biomedical Sciences, Dental School, Research Center for Neuroendocrine Influences on Pain, University of Maryland, Baltimore, MD, USA
    Pain 132:S134-49. 2007
    ....
  19. ncbi TNF-alpha involves in altered prefrontal synaptic transmission in mice with persistent inflammatory pain
    Dong Jia
    Department of Neurosurgery, Tangdu Hospital, and Department of Pharmacology, Fourth Military Medical University, Xi an 710032, China
    Neurosci Lett 415:1-5. 2007
    ..Our findings provide evidence that presynaptic alterations caused by peripheral inflammation is partly attributable to the up-regulation of TNF-alpha in the ACC...
  20. ncbi Cancer pain--a provoker of emotional, social and existential distress
    P Strang
    Palliative Research Unit, Vrinnevi Hospital, Linkoping University, Norrkoping, Sweden
    Acta Oncol 37:641-4. 1998
    ..Pain treatment and education are therefore high-priority matters with effects far beyond the physical suffering...
  21. ncbi Total spinal anesthesia provides transient relief of intractable pain
    Masataka Yokoyama
    Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine and Dentistry, Okayama City, Okayama, Japan
    Can J Anaesth 49:810-3. 2002
    Intentional total spinal anesthesia (TSA) has been used for intractable pain treatment. However, the long-term effect of pain-relief is controversial. We investigate the short- and long-term effects of pain-relief by TSA.
  22. ncbi Thoracoscopic splanchnicectomy for control of intractable pain due to advanced pancreatic cancer
    K Leksowski
    Department of Surgery, Military Clinical Hospital, , 85-915 Bydgoszcz, Poland
    Surg Endosc 15:129-31. 2001
    ..and to determine the ways in which pain may interfere with the common daily activities of patients with intractable pain before and after thoracoscopic splanchnicectomy...
  23. ncbi The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease
    P Klepstad
    Institute of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Acta Anaesthesiol Scand 48:1232-9. 2004
    ..The purpose of the study was to investigate whether this and other genetic polymorphisms in OPRM1 influence the efficacy of morphine in cancer pain patients...
  24. ncbi [The role of interventional pain therapy in palliative care]
    H Gerber
    Institut für Anästhesie und Reanimation, Kantonsspital Luzern
    Praxis (Bern 1994) 93:1240-6. 2004
    ..The complications are mainly technical and are mostly due to catheter obstruction or disconnection. The increasing use of elastomeric pumps reduces the weight of the reservoir and allows the patient an easy adjustment of the flow rate...
  25. ncbi Sublingual methadone for the management of cancer-related breakthrough pain: a pilot study
    Neil A Hagen
    Department of Medicine, Tom Baker Cancer Centre, Alberta, Canada
    J Palliat Med 10:331-7. 2007
    ..Novel analgesic interventions are needed to provide a closer match between the temporal profile of the pain and the pharmacodynamics of the pain medication, and novel models of study of breakthrough pain are needed to evaluate them...
  26. ncbi Opioid plasma concentrations during a switch from transdermal fentanyl to methadone
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Palliat Med 10:338-44. 2007
    ....
  27. ncbi Gaps and junctions between clinical experience and theoretical framework in the use of opioids
    Marianne Kloke
    Support Care Cancer 12:749-51. 2004
  28. ncbi Codeine/acetaminophen and hydrocodone/acetaminophen combination tablets for the management of chronic cancer pain in adults: a 23-day, prospective, double-blind, randomized, parallel-group study
    Rene Fernando Rodriguez
    Department of Anesthesiology and Pain Management, Social Security Institute, Cali, Colombia
    Clin Ther 29:581-7. 2007
    ..Adverse effects (AEs) of the opioids include constipation, somnolence, nausea, and vomiting. Based on the results of a literature search, data comparing the effects of the opioids are lacking...
  29. ncbi Intrathecal drug therapy for long-term pain management
    Virginia L Ghafoor
    Pain Management, Pharmacy Department, University of Minnesota Medical Center UMMC, Minneapolis 55454, USA
    Am J Health Syst Pharm 64:2447-61. 2007
    ..The use, safety, and efficacy of intrathecal medication administration with implantable pumps for cancer and chronic pain management are reviewed...
  30. ncbi [Too many osteoporosis patients are undertreated with analgesics. Chronic pain promotes bone loss]
    J D Ringe
    Klink 4, Allg Innere Med, Klinikum Leverkusen Dhünnberg 60, D 51307 Leverkusen
    MMW Fortschr Med 145:43-5. 2003
    ..Initial experience with opioid therapy in osteoporosis reveals rapid amelioration and improved mobility. Concern about addiction, development of tolerance and problems on discontinuation are unjustified...
  31. ncbi [Validity of recommended minimum dose of prior morphine to initiate transdermal fentanyl patch in prescribing information - multicenter survey of on prescriptions by palliative care specialists in Japan]
    Takahiro Hashizume
    Dept of Surgery, Palliative Care Team, Akita City Hospital
    Gan To Kagaku Ryoho 34:897-902. 2007
    ..Therefore,the RMD regulation is valid for general practitioners from a medical safety standpoint...
  32. ncbi [Strong opioids and constipation]
    A Schwarzer
    Klinik fur Anasthesiologie und Operative Intensivmedizin, Universitatsklinikum Bonn
    Schmerz 19:214-9. 2005
    ..subcutaneous--does not seem to affect the incidence of opioid-induced constipation. Furthermore, prophylaxis and efficient control of opioid-induced constipation still fail to be part of the routine in pain treatment...
  33. ncbi [Treatment of extreme tumour pain with morphine and s-ketamine A case report of an 11-year old girl]
    M Laufer
    Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, Universitat Leipzig
    Schmerz 19:220-4. 2005
    ..Under associated whole-body thermochemotherapy the girl experienced general pain relief and we were able to return to conventional therapy with a fentanyl plaster...
  34. ncbi [Opioids in the treatment of pain--efficient weapon in the expert's hand]
    Eija Kalso
    HYKS, anestesiologia ja tehohoito, kipuklinikka PL 340, 00029 HUS
    Duodecim 120:195-6. 2004
  35. ncbi [Does a doctor care about a cancer patient's pain?]
    Outi Paija
    TYKS n syöpätautien klinikka Savitehtaankatu 1 20520 Turku
    Duodecim 120:665-71. 2004
  36. ncbi Intrathecal opioid treatment for chronic non-malignant pain: a 3-year prospective study
    Mark A Thimineur
    CPHTC, Department of Anesthesiology, Griffin Hospital, 130 Division Street, Derby, CT 06418, USA
    Pain 109:242-9. 2004
    ..The study showed that when patients with extremely severe pain problems are selected as pump candidates, they will likely improve with the therapy, but their overall severity of pain and symptoms still remains high...
  37. ncbi Pain management, including intrathecal pumps
    Thomas J Smith
    Division of Hematology Oncology and Palliative Care, Massey Cancer Center of Virginia Commonwealth University, MCV Box 980230, Richmond, VA 23298 0230, USA
    Curr Oncol Rep 6:291-6. 2004
    ..Given multiple positive small cohort studies and a positive high-power randomized trial, IDDS should be considered as the best treatment for this population...
  38. ncbi Can levorphanol be used like methadone for intractable refractory pain?
    Jack P McNulty
    Palliative Care Institute of Southeast LA, Covington, Louisiana 70433, USA
    J Palliat Med 10:293-6. 2007
    ..A dual effect of action on both opioid receptors and n-methyl, d-aspartate (NMDA) receptors has been proposed to be responsible for this effect...
  39. ncbi Opioid switching from transdermal fentanyl to oral methadone in patients with cancer pain
    Miguel Angel Benitez-Rosario
    Palliative Care Unit and Research Unit, Hospital La Candelaria, Canary Health Service, Tenerife, Spain
    Cancer 101:2866-73. 2004
    ..To the authors' knowledge, no clear guidelines currently exist for the safe and effective rotation from transdermal fentanyl to methadone...
  40. ncbi Neuropsychological assessment of chronic non-malignant pain patients treated in a multidisciplinary pain centre
    Per Sjøgren
    H S Multidisciplinary Pain Centre, Dept 7612, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Eur J Pain 9:453-62. 2005
    ..High scores of PVAS and SVAS were associated with poor performance of PASAT and CRT, respectively. MMSE seems to be too insensitive for detecting the milder forms of cognitive impairment found in chronic non-malignant patients...
  41. pmc Implantable intrathecal pumps for chronic pain: highlights and updates
    Karen H Knight
    Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44108, USA
    Croat Med J 48:22-34. 2007
    ..It is also recommended that future research focus on the outcome, measured by functional parameters rather than commonly used pain scores...
  42. ncbi Intrathecal betamethasone for cancer pain in the lower half of the body: a study of its analgesic efficacy and safety
    H Taguchi
    Department of Anaesthesiology, Kansai Medical University, Moriguchi, Osaka, Japan
    Br J Anaesth 98:385-9. 2007
    ..Sufficient analgesia for cancer pain is sometimes difficult to achieve with conventional treatments. We aimed at investigating the analgesic efficacy and safety of intrathecal betamethasone in patients with uncontrollable cancer pain...
  43. ncbi Changes in G proteins genes expression in rat lumbar spinal cord support the inhibitory effect of chronic pain on the development of tolerance to morphine analgesia
    Mohammad Javan
    Department Physiology, School of Medical Sciences, Tarbiat Modarres University, Tehran, Iran
    Neurosci Res 53:250-6. 2005
    ..The increase in G(alpha i/o) genes expression produced by chronic pain may facilitate the opioid signaling pathway and compensate for morphine-induced tolerance...
  44. ncbi Clinical response to morphine in cancer patients and genetic variation in candidate genes
    J R Ross
    Department of Clinical Genomics, Imperial College, London, UK
    Pharmacogenomics J 5:324-36. 2005
    ..This study presents novel data suggesting that variation in genes involved in mu-opioid receptor signalling influence clinical response to morphine...
  45. ncbi Methadone for cancer pain: a case report
    Alan J Nixon
    Am J Hosp Palliat Care 22:337. 2005
  46. ncbi The DIRE score: predicting outcomes of opioid prescribing for chronic pain
    Miles J Belgrade
    Fairview Pain and Palliative Care Center, University of Minnesota Medical Center and Department of Neurology, University of Minnesota Medical School, Minneapolis, 55454, USA
    J Pain 7:671-81. 2006
    ..For efficacy, sensitivity and specificity were 81% and 76%. For disposition, the sensitivity and specificity were 86% and 73%. Intraclass correlation was 0.94 for interrater reliability and 0.95 for intrarater reliability...
  47. ncbi Efficacy of chronic morphine in a rat model of cancer-induced bone pain: behavior and in dorsal horn pathophysiology
    Catherine E Urch
    Department of Pharmacology, University College London, London, United Kingdom
    J Pain 6:837-45. 2005
    ..Chronic morphine is more effective at attenuating pain-related behaviors than single doses, although the dorsal horn retains a pathophysiologic characterization...
  48. ncbi Ketorolac prevents recurrent withdrawal induced hyperalgesia but does not inhibit tolerance to spinal morphine in the rat
    Stuart A Dunbar
    Department of Anesthesiology, Pain Management Center, Baystate Medical Center, Tufts University, 3400 Main Street, Springfield, MA 01199, USA
    Eur J Pain 11:1-6. 2007
    ....
  49. ncbi Oral transmucosal fentanyl citrate for the treatment of breakthrough pain in cancer patients: an overview of its pharmacological and clinical characteristics
    Kyriaki Mystakidou
    Department of Radiology, University of Athens, Athens, Greece
    Am J Hosp Palliat Care 22:228-32. 2005
    ..In particular, it is going to discuss the synthesis, clinical pharmacology, pharmacokinetic and pharmacodynamic properties, toxicity, and clinical efficacy of this novel agent...
  50. ncbi Does a combination of intensive cognitive-behavioral pain management and a spinal implantable device confer any advantage? A preliminary examination
    Allan R Molloy
    The University of Sydney Pain Management and Research Center, Royal North Shore Hospital, Sydney, New South Wales, Australia
    Pain Pract 6:96-103. 2006
    ....
  51. ncbi Advances in opioid therapy and formulations
    Declan Walsh
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA
    Support Care Cancer 13:138-44. 2005
    ..Optimal opioid use should rely on individualized dose-finding approaches to enhance pain relief while limiting drug-related side effects and avoiding the common problems associated with opioid prescription in clinical practice...
  52. ncbi Survey of assessment criteria prior to implantation of spinal cord stimulators in United Kingdom pain management centres
    Rajeena Ackroyd
    Leeds Pain Management Service, St James Hospital NHS Trust, Leeds, UK
    Eur J Pain 9:57-60. 2005
    ..The development of national guidelines may provide a more standardised approach but further research into the role of the specialist nurse and the benefits of psychological assessment would also be useful...
  53. ncbi [Usefulness of fentanyl patch (Durotep) in cancer patients when rotated from morphine preparations]
    Yasuko Akiyama
    Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, Tokyo
    Masui 56:317-23. 2007
    ..The conversion ratio from morphine to fentanyl has been claimed to be 100:1 or 150:1, but there may exist individual variations...
  54. ncbi Managing pain in patients with aberrant drug-taking behaviors
    Steven D Passik
    Symptom Management and Palliative Care Program, Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536 0093, USA
    J Support Oncol 3:83-6. 2005
  55. ncbi [Is oral medication effective for treatment of pain?]
    Tarja Korhonen
    TAYS, palliatiivinen yksikkö, Tampere
    Duodecim 121:215-9. 2005
  56. ncbi A prospective randomized study of corticosteroids as adjuvant drugs to opioids in advanced cancer patients
    Sebastiano L Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    Am J Hosp Palliat Care 24:13-9. 2007
    ..Corticosteroid-related toxicity was minimal. Further studies with an increased sample size are necessary to detect any minimal difference in analgesia between the two groups...
  57. ncbi Contribution to variability in response to opioids
    Geoffrey W Hanks
    Department of Palliative Medicine, Bristol Haematology and Oncology Centre, University of Bristol, Horfield Road, Bristol, BS2 8ED, UK
    Support Care Cancer 13:145-52. 2005
    ..This article reviews factors that affect the efficacy and tolerability of opioid analgesics and clinical strategies for successful pain mangement...
  58. ncbi An implantable drug delivery system (IDDS) for refractory cancer pain provides sustained pain control, less drug-related toxicity, and possibly better survival compared with comprehensive medical management (CMM)
    T J Smith
    Massey Cancer Center of Virginia Commonwealth University and other institutions, Richmond, VA 23298, USA
    Ann Oncol 16:825-33. 2005
    ..This 'as treated' analysis assessed if improvements in pain control, drug toxicity and survival were maintained over time...
  59. ncbi Spinal cord stimulation: a seven-year audit
    S R Sundaraj
    Pain Management Unit, Nepean Teaching Hospital, Sydney University, Penrith, NSW, Australia
    J Clin Neurosci 12:264-70. 2005
    ..To evaluate the outcome and complications of spinal cord stimulation (SCS) for chronic neuropathic pain in an Australian population...
  60. ncbi Beneficial effect of low-dose ketamine addition to epidural administration of morphine-bupivacaine mixture for cancer pain in two cases
    Selda Sen
    Department of Anesthesiology and Reanimation, State Hospital Anesthesiology and Reanimation Clinic, Adnan Menderes University, Medical Faculty, Aydin, Turkey
    Pain Med 7:166-9. 2006
    ..Low doses of epidural ketamine added to morphine and bupivacaine increase the mean duration of satisfactory analgesia without severe adverse effects and restore quality of life when traditional therapy fails...
  61. ncbi Long-term intrathecal opioid therapy with a patient-activated, implanted delivery system for the treatment of refractory cancer pain
    Richard L Rauck
    Piedmont Anesthesia and Pain Consultants, PA, Winston Salem, NC, USA
    J Pain 4:441-7. 2003
    ..This study demonstrated that patients with refractory cancer pain or intolerable side effects achieved better analgesia when managed with patient-activated intrathecal delivery of morphine sulfate via an implanted delivery system...
  62. ncbi Cancer pain
    Eduardo Bruera
    Department of Palliative Care and Rehabilitation Medicine, University of Texas M D Anderson Cancer Center, Houston, Tex 77030, USA
    JAMA 290:2476-9. 2003
  63. ncbi Opioids in palliative care: emerging clinical trends
    M Ashby
    Palliative Care Unit, Monash Medical Centre, Southern Health, Melbourne, Victoria, Australia
    Intern Med J 33:265-6. 2003
  64. ncbi Intrathecal treatment in cancer patients unresponsive to multiple trials of systemic opioids
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Clin J Pain 23:793-8. 2007
    ....
  65. ncbi Moral conundrums in the courtroom: reflections on a decade in the culture of pain
    Ben A Rich
    Bioethics Program, University of California, Davis, Medical Center, Sacramento, USA
    Camb Q Healthc Ethics 11:180-90. 2002
  66. ncbi Quality of life associated with daily opioid therapy in a primary care chronic pain sample
    Kathryn Sullivan Dillie
    Medical Scientist Training Program, University of Wisconsin Madison, WI, USA
    J Am Board Fam Med 21:108-17. 2008
    ..Daily opioid therapy is widely used in the treatment of chronic noncancer pain, yet there is limited empirical evidence on the relationship of opioid dosing and health-related quality of life (HRQoL) in primary care settings...
  67. ncbi Managing cancer pain with nonpharmacologic and complementary therapies
    Lynette A Menefee Pujol
    Jefferson Pain Center, Department of Anesthesiology, Jefferson Medical College, 834 Chestnut St, Philadelphia, PA 19107 5127, USA
    J Am Osteopath Assoc 107:ES15-21. 2007
    ..This review updates an article published in November 2005. An anecdotal case study has been added to illustrate incorporation of nonpharmacologic and complementary therapies in the treatment of a patient with cancer-related pain...
  68. ncbi Use of patient-controlled analgesia for pain control in dying children
    Christine Schiessl
    Department of Palliative Medicine, University Hospital Cologne, Kerpener Strasse 62, 50924, Cologne, Germany
    Support Care Cancer 16:531-6. 2008
    ..In the last week of life, the daily opioid dose in children is highly variable, making the use of patient-controlled analgesia (PCA) a useful therapy option. Scientific data on the use of PCA in paediatric palliative care are rare...
  69. ncbi Advocating for management of cancer pain
    Barbara Schaefer Bitros
    Life Choice Hospice, 200 Dryden Rd, Suite 3300, Dresher, PA 19025, USA
    J Am Osteopath Assoc 107:ES4-8. 2007
    ..A case vignette describes management of cancer pain in a typical patient admitted to hospice...
  70. ncbi Loss of intrathecal morphine analgesia in terminal cancer patients is associated with high levels of excitatory amino acids in the CSF
    Chih Shung Wong
    Department of Anesthesiology, Tri Service General Hospital and National Defense Medical Center, Taipei, Taiwan
    Can J Anaesth 49:561-5. 2002
    ..To examine excitatory amino acid (EAA) levels in the cerebrospinal fluid (CSF) of patients on long-term morphine treatment for terminal cancer pain relief and to correlate these with morphine's analgesic effect...
  71. ncbi Hydrocodone/acetaminophen and tramadol chlorhydrate combination tablets for the management of chronic cancer pain: a double-blind comparative trial
    Rene Fernando Rodriguez
    Universidad Libre de Cali, Cali, Valle, Colombia
    Clin J Pain 24:1-4. 2008
    ..The purpose of this study was to compare the analgesic efficacy and tolerability of opioids hydrocodone and tramadol in the relief of cancer pain...
  72. ncbi Randomized clinical trial of an implantable drug delivery system
    Mellar P Davis
    J Clin Oncol 21:2800-1; author reply 2802-3. 2003
  73. ncbi Low-dose intrathecal naloxone to enhance intrathecal morphine analgesia: a case report
    Scott Hamann
    Department of Anesthesiology, University of Kentucky, Lexington, USA
    J Opioid Manag 4:251-4. 2008
    ..An IT infusion of daily morphine 5 mg and naloxone 50 ng was started. Throughout the 3-year follow-up period, the patient maintained pain reduction of 60 to 80 percent, with a return to daily activities and no further hospitalizations...
  74. ncbi Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: impact on pain, drug-related toxicity, and survival
    Carla Ripamonti
    J Clin Oncol 21:2801-2; author reply 2802-3. 2003
  75. ncbi [Cancer pain from the nurses' perspective--findings from Austria]
    Olivia Kada
    Fachhochschule Kärnten, Studienbereich Gesundheit und Pflege, Feldkirchen in Kärnten
    Pflege Z 60:626-30. 2007
    ....
  76. ncbi A prospective study evaluating the response of patients with unrelieved cancer pain to parenteral opioids
    Roelien H Enting
    Department of Neuro Oncology, Daniel den Hoed Cancer Center, University Hospital Rotterdam, Rotterdam, The Netherlands
    Cancer 94:3049-56. 2002
    ..There are insufficient data on the efficacy of these strategies, and comparative data are unavailable...
  77. pmc The use of visual analog pain scales in black widow spider envenomation
    Jody J Rogers
    J Med Toxicol 2:46-7. 2006
  78. ncbi Pain in Spain could be on the wane
    A Burton
    Lancet Oncol 3:4. 2002
  79. ncbi OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines
    W Zhang
    University of Edinburgh, Osteoarticular Research Group, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Osteoarthritis Cartilage 16:137-62. 2008
    ....
  80. ncbi Complication, survival rates, and risk factors of surgery for metastatic disease of the spine
    J J Wise
    Department of Orthopaedic Surgery, William Beaumont Hospital, Royal Oak, Michigan, USA
    Spine (Phila Pa 1976) 24:1943-51. 1999
    ..neurologic deficit, neurologic deficit failing to respond to, or progressing after, radiation treatment; intractable pain; radioresistant tumors; or the need for histologic diagnosis...
  81. ncbi Functional neurosurgery for movement disorders: a historical perspective
    Alim Louis Benabid
    CEA Minatec LETI and INSERM, Joseph Fourier University, Grenoble, France
    Prog Brain Res 175:379-91. 2009
    ..1960s, deep brain stimulation and spinal cord stimulation at low frequency (30 Hz) have been used to treat intractable pain of various origins...
  82. ncbi Analgesic effects of a substituted N-triazole oxindole (TROX-1), a state-dependent, voltage-gated calcium channel 2 blocker
    Catherine Abbadie
    Department of Pharmacology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Pharmacol Exp Ther 334:545-55. 2010
    ..TROX-1 demonstrates that an orally available state-dependent Ca(v)2 channel blocker may achieve a therapeutic window suitable for the treatment of chronic pain...
  83. ncbi Open vertebral cement augmentation combined with lumbar decompression for the operative management of thoracolumbar stenosis secondary to osteoporotic burst fractures
    Kern Singh
    Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA
    J Spinal Disord Tech 18:413-9. 2005
    ..Indications for decompression and cement augmentation were intractable pain at the level of a known osteoporotic burst fracture with symptoms of spinal stenosis...
  84. ncbi The clinical efficacy of neuroendoscope in surgical treatment for deafferentation pain
    T Kitamura
    Department of Neurosurgery, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 67:13-7. 2000
    Spinal cord stimulation (SCS) is one of the most minimally invasive and effective treatments for intractable pain. We report the efficacy of a very small diameter neuroendoscope on setting the electrode to the proper site in the epidural ..
  85. ncbi Clinical experience of pain treatment for postherpetic neuralgia in elderly patients
    Siu Wah Chau
    Department of Anesthesiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan, ROC
    Acta Anaesthesiol Taiwan 45:95-101. 2007
    ..The main clinical problem is intractable pain which interferes with activity of daily life and reduces the quality of life in the elderly patients...
  86. ncbi Deep brain stimulation for pain relief: a meta-analysis
    Richard G Bittar
    Department of Neurosurgery, Radcliffe Infirmary, Oxford, UK
    J Clin Neurosci 12:515-9. 2005
    Deep brain stimulation (DBS) has been used to treat intractable pain for over 50 years. Variations in targets and surgical technique complicate the interpretation of many studies...
  87. ncbi Towards standard setting for patient-reported outcomes in the NHS homeopathic hospitals
    Elizabeth A Thompson
    Bristol Homeopathic Hospital, Bristol, UK
    Homeopathy 97:114-21. 2008
    ..We report findings from a pilot data collection study within a programme of quality assurance, improvement and development across all five homeopathic hospitals in the UK National Health Service (NHS)...
  88. pmc Neurogenic pain relief by repetitive transcranial magnetic cortical stimulation depends on the origin and the site of pain
    J P Lefaucheur
    Service de Physiologie Explorations Fonctionnelles, Hopital Henri Mondor, 51 avenue de Lattre de Tassigny, 94010 Creteil, France
    J Neurol Neurosurg Psychiatry 75:612-6. 2004
    ..Drug resistant neurogenic pain can be relieved by repetitive transcranial magnetic stimulation (rTMS) of the motor cortex. This study was designed to assess the influence of pain origin, pain site, and sensory loss on rTMS efficacy...
  89. ncbi Role of pituitary radiosurgery for the management of intractable pain and potential future applications
    Motohiro Hayashi
    Department of Neurosurgery, Neurological Institute, Tokyo Women s Medical University, Tokyo, Japan
    Stereotact Funct Neurosurg 81:75-83. 2003
    ..In the majority of patients, marked pain relief was achieved, surprisingly without any of the complications mentioned above...
  90. ncbi Synovial chondromatosis presenting with cervical radiculopathy: a case report
    Susumu Chiba
    Department of Neurology, School of Medicine, Sapporo Medical University, Sapporo, Japan
    Spine (Phila Pa 1976) 28:E396-400. 2003
    ..A case report is presented...
  91. ncbi Economics of nerve block pain management after anterior cruciate ligament reconstruction: potential hospital cost savings via associated postanesthesia care unit bypass and same-day discharge
    Brian A Williams
    Same Day Surgical Services, University of Pittsburgh Medical Center, Pennsylvania 15203, USA
    Anesthesiology 100:697-706. 2004
    ..In this study, the authors examine the associations of nerve block analgesia for these patients and its associated reductions in PACU use, hospital admission, and hospital costs...
  92. ncbi The role of spinal opioid receptors in antinociceptive effects produced by intrathecal administration of hydromorphone and buprenorphine in the rat
    Gopi A Tejwani
    Department of Pharmacology, College of Medicine and Public Health, Ohio State University, 5197 Graves Hall, 333 W 10th Avenue, Columbus, OH 43210 1239, USA
    Anesth Analg 94:1542-6, table of contents. 2002
    The intrathecal administration of morphine has been the standard therapy to control long-term intractable pain. Recently, a panel of pain therapy experts suggested that because of the lack of efficacy or because of the side effects ..
  93. ncbi Transduodenal sphincteroplasty in the management of sphincter of Oddi dysfunction and pancreas divisum in the modern era
    Katherine A Morgan
    Department of Surgery, Digestive Diseases Center, Medical University of South Carolina, Charleston, SC 29425, USA
    J Am Coll Surg 206:908-14; discussion 914-7. 2008
    ..A retrospective review of sphincter of Oddi dysfunction and pancreas divisum patients who underwent TS for refractory pain in a recent time period was undertaken...
  94. ncbi Spinal cord stimulation electrode design: prospective, randomized, controlled trial comparing percutaneous and laminectomy electrodes-part I: technical outcomes
    Richard B North
    Department of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287 7713, USA
    Neurosurgery 51:381-9; discussion 389-90. 2002
    The clinical use of spinal cord stimulation for treatment of chronic intractable pain has been increasingly successful because of recent technical improvements, particularly the development of multiple-contact electrodes supported by ..
  95. ncbi Long-term outcome after resection for chronic pancreatitis in 224 patients
    Hartwig Riediger
    Department of Surgery, University of Freiburg, Hugstetter Str 55, 79106, Freiburg, Germany
    J Gastrointest Surg 11:949-59; discussion 959-60. 2007
    Organ complications like biliary or duodenal stenosis as well as intractable pain are current indications for surgery in patients with chronic pancreatitis (CP)...
  96. ncbi Catheter-associated masses in patients receiving intrathecal analgesic therapy
    Marion R McMillan
    Foothills Regional Pain Center and Mountainview Medical Imaging, Seneca, South Carolina, USA
    Anesth Analg 96:186-90, table of contents. 2003
    A cohort of seven patients receiving intrathecal analgesic drug therapy for chronic intractable pain underwent radiocontrast myelography and computed tomography (CT) scanning to screen for catheter-associated intrathecal masses...
  97. ncbi [Discogenic low back pain and degenerative lumbar spinal stenosis - how appropriate is surgical treatment?]
    H M Mayer
    Orthopädische Klinik München Harlaching Wirbelsäulenzentrum, Munchen
    Schmerz 15:484-91. 2001
    ..in patients with progressive neurological symptoms, unacceptable decrease of quality of life or progressive intractable pain. In patients with mainly "leg symptoms" microsurgical mono- or multisegmental decompression is the procedure ..
  98. ncbi Radiotherapy in painful heel spurs (plantar fasciitis)--results of a national patterns of care study
    Oliver Micke
    Department of Radiotherapy, Munster University Hospital, Munster, Germany
    Int J Radiat Oncol Biol Phys 58:828-43. 2004
    ..After a general patterns of care study, the German Cooperative Group on Radiotherapy for Benign Diseases conducted a multicenter cohort study to analyze radiotherapy (RT) in painful heel spur syndrome (HSS)...
  99. ncbi [Clinical characteristics and diagnosis of rheumatoid arthritis of upper cervical spine: analysis of 71 cases]
    Wang jun Yan
    Department of Orthopedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
    Zhonghua Yi Xue Za Zhi 88:901-4. 2008
    ..To study the clinical characteristics and diagnosis of rheumatoid arthritis (RA) in the upper cervical spine...
  100. ncbi Reconstruction of chronic aseptic sternal pseudoarthrosis after median sternotomy: initial experience with the Ley prosthesis
    Rafael Astudillo
    Department of Cardiothoracic Surgery, St Olavs Hospital, Trondheim, Norway
    Heart Surg Forum 11:E46-9. 2008
    ..The study included 6 male patients (age 42-80 years) with opiate-derivate-dependent intractable pain and significantly reduced quality of life caused by noninfected sternal pseudoarthrosis and unstable ..
  101. ncbi Surgical treatment of peptic ulcer disease: changing patterns in the past 40 years
    C N Chen
    Department of Surgery, National Taiwan University Hospital, Taipei, ROC
    J Formos Med Assoc 95:675-9. 1996
    ..In the earlier period, the indications for surgery were hemorrhage (38.4%), perforation (36.1%), intractable pain (16.4%) and stenosis (9.1%). Perforation (89...

Research Grants62

  1. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Pancreatic inflammation results in morbidity and mortality, with severe intractable pain. The mechanisms of acute pancreatitis and pancreatitis pain are very poorly understood...
  2. Online patient self-assessment for chronic pancreatic and other pain
    Andrew H Soll; Fiscal Year: 2011
    ..Although we focus on chronic pancreatic pain, we are using a general approach that will be applicable to any chronic pain or non-pain symptom. ..
  3. The role of trace metals and T-channels in pain
    Slobodan M Todorovic; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Intractable pain has significant adverse effects on quality of life measures, and none of the available treatments can completely reverse these symptoms. Recent studies have established that CaV3...
  4. Novel Strategies to Increase Insulin Independence after Islet Autotransplantation
    Hongjun Wang; Fiscal Year: 2013
    ..Total pancreatectomy with islet autotransplantation (TP-IAT) is currently being performed to treat intractable pain and to prevent "brittle" diabetes in well-selected patients with chronic pancreatitis...
  5. Satellite Glial Cells
    Luc Jasmin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Approximately 6% of the American population suffers from intractable pain following nerve injury;yet available treatment options are only marginally effective...
  6. ALTERED SENSIBILITY FOLLOWING PERIPHERAL NERVE DAMAGE
    Clifford J Woolf; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE Peripheral nerve injury can result in severe intractable pain resistant to most forms of therapy (peripheral neuropathic pain)...
  7. Islet and Mesenchymal Stem Cell Co-transplantation Prevents Onset of Diabetes
    Hongjun Wang; Fiscal Year: 2013
    ..Total pancreatectomy and islet autotransplantation (TP-IAT) are currently being performed to treat intractable pain in selected patients with chronic pancreatitis (CP)...
  8. Integration of Immunochemical, Genomic & Transcriptomic Analyses of Human Skin
    FRANK LAMBERT contact RICE; Fiscal Year: 2010
    ..neuropathies, are among the most common and debilitating human afflictions due to the occurrence of severe, intractable pain. Existing treatments have little long term benefits and often have severe side effects...
  9. Transgenic Tethered Peptides
    Michael N Nitabach; Fiscal Year: 2013
    ..of neuropeptide signaling mechanisms-such as narcolepsy, obesity, addiction, post- traumatic stress disorder, intractable pain, etc-are a major source of morbidity, mortality, and economic hardship...
  10. Strategies for early treatment of bone metastases
    Julie A Sterling; Fiscal Year: 2013
    ..Bone metastases are devastating to the patient as they are associated with intractable pain, hypercalcemia (abnormally high concentration of calcium in the blood), disabling pathologic fractures, and ..
  11. Nociceptive Role of SST and NT receptor-expressing dorsal horn neurons
    RONALD GORDON WILEY; Fiscal Year: 2013
    ..These novel strategies for tonically exciting inhibitory interneurons with CTA,may open a new chapter in the search for safer, more effective ways to manage chronic, intractable pain.
  12. Metaplasticity and Recovery After Spinal Cord Injury: Cellular Mechanisms
    Adam R Ferguson; Fiscal Year: 2012
    ..to re-establish essential functions, while limiting the maladaptive plasticity that can lead to spasticity or intractable pain. By defining key mechanisms that disable spinal cord learning and recovery of function, we hope to provide ..
  13. The Effects of Ketogenic Diets on Inflammation and Chronic Pain
    DAVID NATHANIEL RUSKIN; Fiscal Year: 2010
    ..Our central hypothesis is that a ketogenic diet will alleviate pain, including intractable pain, based on its anti-inflammatory potential and akin to its success in treating intractable epilepsy...
  14. Contribution of ADA1A polymorphism to persistent pain states
    SHAD BENJAMIN SMITH; Fiscal Year: 2010
    ..There is growing evidence that intractable pain is frequently comorbid with anxiety, depression, and other psychological traits, often manifesting as ..
  15. Deep brain stimulation of the ventral anterior limb of the internal capsule for m
    Andre Machado; Fiscal Year: 2009
    ..stimulating these networks, we expect to modulate the affective sphere of patients with otherwise intractable pain and, consequently, reduce pain related disability...
  16. Linkage and candidate gene analysis in non-syndromic Chiari type I
    Simon G Gregory; Fiscal Year: 2013
    ..abstract_text> ..
  17. Structural and Molecular Neuroplasticity in Chronic Trigeminal Pain
    Alexandre Dasilva; Fiscal Year: 2013
    ..This project is expected to expand our knowlegde on cortical migraine pathophysiology, and possibly novel therapeutic targets in the brain. ..
  18. Wear, Inflammation and Clinical Performance of Total Disc Replacement
    STEVEN MICHAEL KURTZ; Fiscal Year: 2013
    ..g. heterotopic ossification (HO) and intractable pain. } To investigate the potential failure modes of TDRs, we propose to elucidate mechanisms of in vivo ..
  19. TGF-Beta Bone Fragility at the Tumor-Bone Interface in Myeloma
    Gregory R Mundy; Fiscal Year: 2012
    ..Myeloma is a disease characterized by catastrophic effects on the skeleton resulting in intractable pain and susceptibility to fracture, indicating a marked increase in bone fragility...
  20. Preclinical Development of an NT3-expressing HSV Vector
    David J Fink; Fiscal Year: 2013
    ..taken a non-replicating HSV vector expressing preproenkephalin into phase 1 clinical trial in patients with intractable pain from cancer...
  21. BIOBEHAVIORAL PREDICTORS OF POSTOP PAIN & IMMUNE STATUS
    Joel Katz; Fiscal Year: 1999
    ..pain intensity, increase the need for analgesics, and set the stage for the development of chronic, intractable pain. One of the most effective ways to prevent noxious input during surgery from reaching the spinal cord is to ..
  22. Glutamate in Peripheral afferents during inflammation
    Kenneth Miller; Fiscal Year: 2007
    ..These results may be beneficial in the development of novel therapies for patients with intractable pain by addressing the regulation of glutamate in peripheral tissues. [unreadable] [unreadable]
  23. Chimeric Peptides As Novel Analgesics
    Richard Kream; Fiscal Year: 2004
    ..with high intensity despite the presence of extensive endogenous pain-modulating systems, and why chronic intractable pain arises from pathophysiological sequelae of nerve injury without consistency of symptomatology, etiological ..
  24. Mast Cells: Role in the Pathophysiology of Headache
    Dan Levy; Fiscal Year: 2007
    ..Results may help identify pharmacological targets that could lead to the development of novel analgesic drugs for the treatment of headaches and possibly other intractable pain syndromes. [unreadable] [unreadable] [unreadable]
  25. Steroids-Functional Modulators of Amino Acid Receptors
    DAVID FARB; Fiscal Year: 2007
    ..and long-term memory, and have been implicated in a variety of pathological conditions, including stroke, intractable pain, neurodegenerative diseases, and spinal cord injury...
  26. GENETIC DISSECTION OF GLUTAMATE RECEPTOR FUNCTION
    STEPHEN HEINEMANN; Fiscal Year: 2006
    ..place as part of the mechanism of many neurological diseases such as epilepsy, drug addiction and long term intractable pain. Long-term alterations in synaptic function may explain the symptoms of withdrawal experienced by addicts ..
  27. Analgesic effects of adrenal chromaffin cell transplants
    George Pappas; Fiscal Year: 2007
    ..transplantation of allogeneic chromaffin cell graft clearly shows potential as a means of treating chronic, intractable pain. Unfortunately, transplantation of allogeneic chromaffin cells has limitations similar to other transplants, ..
  28. ENDOCANNABINOID MECHANISMS OF STRESS INDUCED ANALGESIA
    Andrea Hohmann; Fiscal Year: 2002
    ..The proposed work is significant because the potential of nonopioid mechanisms for suppressing intractable pain cannot be realized until the underlying endogenous analgesic systems have been identify led...
  29. PHYSIOLOGICAL CORRELATES OF NEURAL PLASTICITY
    LILLIAN PUBOLS; Fiscal Year: 1993
    ..These results may ultimately lead to new drug therapies for the treatment of intractable pain after spinal cord injury.
  30. EIHC and Prostate Cancer Adhesion to Bone Endothelium
    Carlton Cooper; Fiscal Year: 2004
    Prostate cancer bone metastasis is a major clinical problem and is commonly associated with intractable pain and spinal cord compression. Nearly 100% of men who die of prostate cancer have bone metastases...
  31. Development of High Throughput Assays for N-type Calcium Channels
    Edward Perez Reyes; Fiscal Year: 2007
    ..selective for N-type channels, demonstrated safety and efficacy in clinical trials for the treatment of intractable pain in cancer and AIDS patients after intrathecal infusion...
  32. Novel Total Disc Implants
    Ashok Khandkar; Fiscal Year: 2004
    Spinal disc herniation and the resulting symptoms of intractable pain, weakness, sensory loss, incontinence and progressive arthritis are among the most common debilitating conditions back problems...
  33. Polymodal Electrode System for Intracranial Applications
    Lee Margolin; Fiscal Year: 2002
    ..ablation or chronic deep brain stimulation for the treatment of movement disorders, epilepsy and intractable pain has established these techniques as viable alternatives when other medical options are unsuitable...
  34. BIOMECHANICS OF METASTATIC DEFECTS IN BONE
    Brian Snyder; Fiscal Year: 2002
    ..Pathologic fracture occurs in 30 percent of skeletal metastases causing intractable pain, loss of function and other morbidities...
  35. Motor Imagery as a Measure of Pain Severity
    H Coslett; Fiscal Year: 2007
    Progress in the treatment of chronic, intractable pain has been limited by the lack of reliable, quantifiable measures of pain severity. Many types of chronic pain are exacerbated by movement...
  36. CGX-1160, a non-opioid, broad-spectrum analgesic
    John Wagstaff; Fiscal Year: 2001
    ..with a wide separation between efficacy and toxicity, and may represent an alternative therapy for intractable pain. In phase I we will demonstrate the efficacy of CGX-1160 in a broad range of animal pain models including: ..
  37. VIRAL EXPRESSION OF OPIOID RECEPTORS FOR SEVERE PAIN
    ANDREW MANNES; Fiscal Year: 2001
    ..systems and physician awareness, a significant population of cancer patients continue to experience severe, intractable pain. Alternative treatment addressing severe pain would substantially reduce the suffering and improve the ..
  38. TMS treatment for pain in chronic pancreatitis
    Steven Freedman; Fiscal Year: 2006
    ..This study represents the first to define a potential mechanism of refractory pain in this disease - brain dysfunction of the somatosensory cortex - and provide a novel therapy. [unreadable] [unreadable]..
  39. SELECTIVE KILLING OF PAIN NEURONS BY LASER PHOTOLYSIS
    JAMES HSIA; Fiscal Year: 1992
    ..This technology would offer a therapy for intractable pain syndromes associated with malignancy, metabolic neuropathies, and peripheral nervous system trauma.
  40. NOVEL TREATMENT FOR INTRACTABLE PAIN
    Peter Kelleher; Fiscal Year: 1993
    b>Intractable pain is chronic pain for which there is little or no effective therapy...
  41. Treatment of Chroinc Pain Using Real Time Functional MRI
    CHRISTOPHER DECHARMS; Fiscal Year: 2009
    ..This trial will be conducted at leading fMRI research centers (Stanford, MIT, and Omneuron) with similar size to other pain therapeutics trials (N=72 per group, 36 per sub-group), and including a blind, randomized placebo control. ..
  42. ROLE OF INDIVIDUAL BRAINSTEM NEURONS IN PAIN INHIBITION
    IAN HENTALL; Fiscal Year: 1992
    ..in opiate analgesia, it will provide basic data on electrical brain stimulation which may improve the efficiency of the technique whether for surgical relief of chronic intractable pain or for any other scientific or medical application.
  43. CHRONIC CENTRAL PAIN IN SPINAL CORD INJURY
    CLAIRE HULSEBOSCH; Fiscal Year: 2005
    ..There are three cores: an administrative core, an animal core and a morphology core. The results for these studies will guide the development of strategic interventions to improve functional outcome after SCI. ..
  44. SYMPTOMS OF TRANSPLANT PATIENTS NEAR THE END OF LIFE
    Karen Anderson; Fiscal Year: 2003
    ..It is predicted that patients in the experimental condition who die during the year will demonstrate better symptom management and quality of the end of life than patients in the control condition. ..
  45. WEB-BASED MANAGEMENT TRAINING: ADDICTION-RESOURCES.COM
    Stephen Butler; Fiscal Year: 2003
    ..An analogue field trial will examine, in contrast to a written booklet and wait-list control, the website's effectiveness in facilitating managers to more use of clinical data in decision-making. ..
  46. Phase II Developmental Study on Fatigue in Cancer
    RICARDO CRUCIANI; Fiscal Year: 2002
    ..An interim analysis will be done once 15 patients have been observed in each group at 4 weeks. Paired and unpaired data analyses between groups will be conducted with the assistance of a statistician. ..
  47. PATIENT AND PUBLIC EDUCATION IN CANCER PAIN MANAGEMENT
    Betty Ferrell; Fiscal Year: 2002
    ..This course will impact 120 healthcare settings to improve pain management and quality of life in cancer patients and to establish model pain education programs for national dissemination. ..
  48. Screening for Addiction Risk in Chronic Opioid Therapy
    Stephen Butler; Fiscal Year: 2005
    ..Substantial Phase III support has been committed by Endo Pharmaceuticals. The resulting measure should be reliable, valid, and easy to use in practice settings. ..
  49. Cortical Dynamics for Pain Perception in Behaving Rats
    APKAR APKARIAN; Fiscal Year: 2005
    ..abstract_text> ..
  50. Pain Management in Temporomandibular Joint Disorders
    Jennifer Haythornthwaite; Fiscal Year: 2005
    ..abstract_text> ..
  51. Oncology Nursing Education in End of Life Care
    Betty Ferrell; Fiscal Year: 2007
    ..This proposal includes extensive evaluation planned to monitor individual and institutional dissemination. [unreadable] [unreadable] [unreadable]..
  52. Gene and Cell Therapy of Duchenne Muscular Dystrophy
    Joseph Glorioso; Fiscal Year: 2008
    ..We believe this to be a timely and highly innovative proposal which is likely to provide new armroaches to the treatment of muscular dvstrophv. ..
  53. Pain Assessment Interview and Clinical Advisory System
    Stephen Butler; Fiscal Year: 2008
    ..Thus, we believe this product has enormous commercial viability and public health importance. [unreadable] [unreadable] [unreadable] [unreadable]..
  54. Characterizing temporal dynamics of spontaneous pain
    APKAR APKARIAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  55. HIV Clade on Cognitive and Neurological Disorders Brazil
    Ronald Ellis; Fiscal Year: 2007
    ..UCSD investigators will train and guide the administration and interpretation of the clinical assessment instruments, transfer technology to the Brazilian site. [unreadable] [unreadable]..
  56. HIV Neurocognitive Disorders: A Randomized Clinical Trial of CNS-Targeted HAART
    Ronald J Ellis; Fiscal Year: 2010
    ..The proposed clinical trial would provide the level of evidence needed to formulate ART guidelines specific to HNCI. ..
  57. Chronic Pain Prevention after SCI and Limb Loss
    Dawn Ehde; Fiscal Year: 2006
    ..abstract_text> ..
  58. Internet Monitoring Of Prescription Drug Abuse
    Stephen Butler; Fiscal Year: 2006
    ..Phase II will see development of a full prototype of PRISM and demonstration of its reliability and internal and external validity. [unreadable] [unreadable] [unreadable] [unreadable]..
  59. End of Life Nursing Education through Graduate Programs
    Betty Ferrell; Fiscal Year: 2006
    ..This proposal includes extensive evaluation planned to monitor individual and institutional dissemination. ..
  60. Telephone Counseling: Men w/Prostate CA & Partners
    Terry Badger; Fiscal Year: 2007
    ..Data will be analyzed through descriptive statistics, a series of two-way mixed design ANOVAs and individual regression analyses. [unreadable] [unreadable] [unreadable]..