chest pain

Summary

Summary: Pressure, burning, or numbness in the chest.

Top Publications

  1. doi Early diagnosis of myocardial infarction with sensitive cardiac troponin assays
    Tobias Reichlin
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    N Engl J Med 361:858-67. 2009
  2. ncbi Prognostic value of myeloperoxidase in patients with chest pain
    Marie Luise Brennan
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland 44195, USA
    N Engl J Med 349:1595-604. 2003
  3. doi High-sensitive cardiac troponin T outperforms novel diagnostic biomarkers in patients with acute chest pain
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden
    Clin Chim Acta 413:1135-40. 2012
  4. pmc The health care burden of acute chest pain
    S Goodacre
    Heart 91:229-30. 2005
  5. ncbi ACCF/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Cl
    Philip Greenland
    Circulation 115:402-26. 2007
  6. doi Sensitive troponin I assay in early diagnosis of acute myocardial infarction
    Till Keller
    Department of Medicine II, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    N Engl J Med 361:868-77. 2009
  7. ncbi Review article: the burden of illness of non-cardiac chest pain
    G D Eslick
    Department of Medicine, The University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    Aliment Pharmacol Ther 16:1217-23. 2002
  8. doi Chest pain of cardiac and noncardiac origin
    Claude Lenfant
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Metabolism 59:S41-6. 2010
  9. doi The association between emergency department crowding and adverse cardiovascular outcomes in patients with chest pain
    Jesse M Pines
    Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Acad Emerg Med 16:617-25. 2009
  10. pmc Effect of providing information about normal test results on patients' reassurance: randomised controlled trial
    Keith J Petrie
    Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, New Zealand
    BMJ 334:352. 2007

Detail Information

Publications365 found, 100 shown here

  1. doi Early diagnosis of myocardial infarction with sensitive cardiac troponin assays
    Tobias Reichlin
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    N Engl J Med 361:858-67. 2009
    ..The rapid and reliable diagnosis of acute myocardial infarction is a major unmet clinical need...
  2. ncbi Prognostic value of myeloperoxidase in patients with chest pain
    Marie Luise Brennan
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland 44195, USA
    N Engl J Med 349:1595-604. 2003
    ..Numerous lines of evidence suggest mechanistic links between myeloperoxidase and both inflammation and cardiovascular disease...
  3. doi High-sensitive cardiac troponin T outperforms novel diagnostic biomarkers in patients with acute chest pain
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden
    Clin Chim Acta 413:1135-40. 2012
    Measurement of high-sensitive cardiac troponin (hs-cTn) has facilitated the early diagnostic assessment of chest pain patients...
  4. pmc The health care burden of acute chest pain
    S Goodacre
    Heart 91:229-30. 2005
  5. ncbi ACCF/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Cl
    Philip Greenland
    Circulation 115:402-26. 2007
  6. doi Sensitive troponin I assay in early diagnosis of acute myocardial infarction
    Till Keller
    Department of Medicine II, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    N Engl J Med 361:868-77. 2009
    ..Cardiac troponin testing is central to the diagnosis of acute myocardial infarction. We evaluated a sensitive troponin I assay for the early diagnosis and risk stratification of myocardial infarction...
  7. ncbi Review article: the burden of illness of non-cardiac chest pain
    G D Eslick
    Department of Medicine, The University of Sydney, Nepean Hospital, Penrith, NSW, Australia
    Aliment Pharmacol Ther 16:1217-23. 2002
    Non-cardiac chest pain is a common condition affecting approximately one-quarter of the population during their lifetime, but the long-term economic costs of non-cardiac chest pain are poorly defined.
  8. doi Chest pain of cardiac and noncardiac origin
    Claude Lenfant
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Metabolism 59:S41-6. 2010
    b>Chest pain is one of the most common symptoms driving patients to a physician's office or the hospital's emergency department...
  9. doi The association between emergency department crowding and adverse cardiovascular outcomes in patients with chest pain
    Jesse M Pines
    Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Acad Emerg Med 16:617-25. 2009
    ..The authors examined whether ED crowding was associated with adverse cardiovascular outcomes in patients with chest pain syndromes (chest pain or related complaints of possible cardiac origin).
  10. pmc Effect of providing information about normal test results on patients' reassurance: randomised controlled trial
    Keith J Petrie
    Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, New Zealand
    BMJ 334:352. 2007
    ..To investigate whether providing information about normal findings before a diagnostic test improves patients' reassurance and reduces anxiety about symptoms...
  11. ncbi How useful are clinical features in the diagnosis of acute, undifferentiated chest pain?
    Steve Goodacre
    Medical Care Research Unit, University of Sheffield, Sheffield, United Kingdom
    Acad Emerg Med 9:203-8. 2002
    To measure the predictive value and diagnostic performance of clinical features used to diagnose coronary syndromes in patients presenting with acute, undifferentiated chest pain.
  12. doi Clinical value of diagnostic instruments for ruling out acute coronary syndrome in patients with chest pain: a systematic review
    Johann Steurer
    Department of Internal Medicine, University of Zurich, Zurich, Switzerland
    Emerg Med J 27:896-902. 2010
    Acute chest pain is a frequent reason to attend an emergency room, and various instruments for calculating the probability of an acute coronary syndrome exist.
  13. doi A method for improving arrival-to-electrocardiogram time in emergency department chest pain patients and the effect on door-to-balloon time for ST-segment elevation myocardial infarction
    Kevin M Takakuwa
    Department of Emergency Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, USA
    Acad Emerg Med 16:921-7. 2009
    ..to a door-to-electrocardiogram (ECG) time goal of 10 minutes or less for patients who presented to an ED with chest pain and the effect of this adherence on door-to-balloon (DTB) time for ST-segment elevation myocardial infarction (..
  14. doi Comparison of contemporary troponin assays with the novel biomarkers, heart fatty acid binding protein and copeptin, for the early confirmation or exclusion of myocardial infarction in patients presenting to the emergency department with chest pain
    Paul Collinson
    Department of Clinical Blood Sciences, St George s Hospital and Medical School, London, UK
    Heart 100:140-5. 2014
    ..To examine the diagnostic accuracy of novel biomarkers of myocardial injury and troponin assays for diagnosis of myocardial infarction...
  15. pmc Coronary CT angiography versus standard evaluation in acute chest pain
    Udo Hoffmann
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 367:299-308. 2012
    ..It is unclear whether an evaluation incorporating coronary computed tomographic angiography (CCTA) is more effective than standard evaluation in the emergency department in patients with symptoms suggestive of acute coronary syndromes...
  16. pmc Effect of marriage on duration of chest pain associated with acute myocardial infarction before seeking care
    Clare L Atzema
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    CMAJ 183:1482-91. 2011
    ..We aimed to determine whether marital status was a predictor of the duration of chest pain endured by patients with acute myocardial infarction before they sought care and whether the patient's sex ..
  17. pmc Diagnostic accuracy of the TIMI risk score in patients with chest pain in the emergency department: a meta-analysis
    Erik P Hess
    Department of Emergency Medicine, Division of Emergency Medicine Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    CMAJ 182:1039-44. 2010
    ..We sought to expand the clinical application of the TIMI risk score by assessing its prognostic accuracy in patients in the emergency department with potential acute coronary syndromes...
  18. doi Copeptin does not add diagnostic information to high-sensitivity troponin T in low- to intermediate-risk patients with acute chest pain: results from the rule out myocardial infarction by computed tomography (ROMICAT) study
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 57:1137-45. 2011
    ..sought to evaluate the predictive value of copeptin and its incremental value beyond that of high-sensitivity cardiac troponin T (hs-cTnT) in patients with acute chest pain and low to intermediate risk for acute coronary syndrome (ACS).
  19. doi Combined copeptin and troponin to rule out myocardial infarction in patients with chest pain and a history of coronary artery disease
    Patrick Ray
    Department of Emergency Medicine, Pitie Salpetriere Hospital, Assistance Publique Hopitaux de Paris AP HP, INSERM UMRS 956, Universite Pierre et Marie Curie Paris 6, 75013, Paris, France
    Am J Emerg Med 30:440-8. 2012
    ..was to evaluate the additional value of copeptin to conventional cardiac troponin (cTn) for a rapid ruling out of acute myocardial infarction (AMI) in patients with acute chest pain and a previous history of coronary artery disease (CAD).
  20. ncbi Application of the TIMI risk score for unstable angina and non-ST elevation acute coronary syndrome to an unselected emergency department chest pain population
    Charles V Pollack
    Department of Emergency Medicine, Pennsylvania Hospital, University of Pennsylvania Health System, Philadelphia, PA, USA
    Acad Emerg Med 13:13-8. 2006
    Patients presenting with chest pain or related symptoms suggestive of myocardial ischemia, without ST-segment elevation (NSTE) on their presenting electrocardiograms, often present a diagnostic challenge in the emergency department (ED)...
  21. ncbi Relation between coronary artery calcium and incident chest pain in a community-dwelling screening population
    Allen J Taylor
    Cardiology Service, Walter Reed Army Medical Center, Washington, DC, USA
    Am J Cardiol 96:61-3. 2005
    Incident chest pain occurred in 30.3% of 1,743 asymptomatic healthy men and women who were followed for up to 4 years...
  22. ncbi Detecting acute coronary syndrome in the emergency department with cardiac magnetic resonance imaging
    Raymond Y Kwong
    Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1061, USA
    Circulation 107:531-7. 2003
    Managing chest pain in the emergency department remains a challenge with current diagnostic strategies. We hypothesized that cardiac MRI could accurately identify patients with possible or probable acute coronary syndrome.
  23. doi Chest wall pain and rib fracture after stereotactic radiotherapy for peripheral non-small cell lung cancer
    Jon Paul J Voroney
    Department of Radiation Oncology, Tom Baker Cancer Centre Alberta, Canada
    J Thorac Oncol 4:1035-7. 2009
    ..The median dose to rib fracture sites was 46 to 50 Gy, depending on the method of dose calculation. We describe a typical case of poststereotactic radiotherapy rib fracture and present dosimetric analysis of patients with rib fracture...
  24. ncbi Women's early warning symptoms of acute myocardial infarction
    Jean C McSweeney
    College of Nursing, University of Arkansas for Medical Sciences, 4301 W Markham St, Slot 529, Little Rock, AR 72205, USA
    Circulation 108:2619-23. 2003
    ..Data remain sparse on women's prodromal symptoms before acute myocardial infarction (AMI). This study describes prodromal and AMI symptoms in women...
  25. ncbi The diagnostic accuracy of 64-slice computed tomography coronary angiography compared with stress nuclear imaging in emergency department low-risk chest pain patients
    Michael J Gallagher
    Department of Cardiology, William Beaumont Hospital, Royal Oak, MI 48073, USA
    Ann Emerg Med 49:125-36. 2007
    We compared the accuracy of multidetector computed tomography (CT) coronary angiography with stress nuclear imaging for the detection of an acute coronary syndrome or 30-day major adverse cardiac events in low-risk chest pain patients.
  26. ncbi Validation of a brief observation period for patients with cocaine-associated chest pain
    Jim Edward Weber
    Departments of Emergency Medicine, University of Michigan, Ann Arbor, and Hurley Medical Center, Flint, Mich, USA
    N Engl J Med 348:510-7. 2003
    Retrospective studies of patients with cocaine-associated chest pain suggest that a strategy of discharging patients from the emergency department after a 12-hour observation period if they do not have evidence of ischemia should be ..
  27. ncbi Chest pain in general practice: incidence, comorbidity and mortality
    Ana Ruigómez
    Centro Español de Investigación Farmacoepidemiológica CEIFE, Madrid, Spain
    Fam Pract 23:167-74. 2006
    b>Chest pain is a common symptom that presents the primary care physician with a complex diagnostic and therapeutic challenge.
  28. doi Diagnostic value of high sensitive troponin T in chest pain patients with no persistent ST-elevations
    Dina Melki
    Section of Cardiology, Department of Medicine, Karolinska University Hospital, Huddinge Karolinska Institutet, Stockholm, Sweden
    Scand Cardiovasc J 45:198-204. 2011
    ..The aim of this study was to compare the early diagnostic value of the Roche high-sensitive troponin T (Hs-TnT) and that of conventional troponins...
  29. doi A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): a prospective observational validation study
    Martin Than
    Christchurch Hospital, Christchurch, New Zealand
    Lancet 377:1077-84. 2011
    Patients with chest pain contribute substantially to emergency department attendances, lengthy hospital stay, and inpatient admissions...
  30. ncbi A clinical prediction rule for early discharge of patients with chest pain
    Jim Christenson
    The Center for Health Evaluation and Outcome Sciences, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
    Ann Emerg Med 47:1-10. 2006
    ....
  31. doi Response of unexplained chest pain to proton pump inhibitor treatment in patients with and without objective evidence of gastro-oesophageal reflux disease
    Peter J Kahrilas
    Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 2951, USA
    Gut 60:1473-8. 2011
    Unexplained chest pain is potentially attributable to gastro-oesophageal reflux disease (GORD) or oesophageal motility disorders. Reflux chest pain may occur without heartburn...
  32. ncbi Door-to-ECG time in patients with chest pain presenting to the ED
    Deborah B Diercks
    Division of Emergency Medicine, University of California, Davis Medical Center, Sacramento, 95817, USA
    Am J Emerg Med 24:1-7. 2006
    ..To describe time to electrocardiogram (ECG) acquisition, identify factors associated with timely acquisition, and evaluate the influence of time to ECG on adverse clinical outcomes...
  33. doi A 2-hour diagnostic protocol for possible cardiac chest pain in the emergency department: a randomized clinical trial
    Martin Than
    Emergency Department, Christchurch Hospital, Christchurch, New Zealand
    JAMA Intern Med 174:51-8. 2014
    Patients with chest pain represent a high health care burden, but it may be possible to identify a patient group with a low short-term risk of adverse cardiac events who are suitable for early discharge.
  34. ncbi Prospective validation of the Thrombolysis in Myocardial Infarction Risk Score in the emergency department chest pain population
    Maureen Chase
    Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Ann Emerg Med 48:252-9. 2006
    ..To validate the use of the TIMI risk score in the ED, we prospectively assess its potential utility in a broad ED chest pain patient population.
  35. doi Myeloperoxidase is not useful for the early assessment of patients with chest pain
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University Hospital and Uppsala Clinical Research Center, Uppsala, Sweden
    Clin Biochem 43:240-5. 2010
    Myeloperoxidase (MPO) has been listed as a potentially useful risk marker in acute coronary syndrome. However, its clinical utility in patients with acute chest pain is not yet defined.
  36. pmc The role of myeloperoxidase (MPO) for prognostic evaluation in sensitive cardiac troponin I negative chest pain patients in the emergency department
    Julia Searle
    Department of Cardiology, CVK and Emergency Medicine CVK, CCM, Charite Universitatsmedizin Berlin, Germany
    Eur Heart J Acute Cardiovasc Care 2:203-10. 2013
    The diagnostic work-up of patients with acute chest pain in the emergency department (ED) is a challenging task. Serial troponin testing is required to rule-out acute myocardial infarction.
  37. pmc Chest pain and ischaemic heart disease in primary care
    S Nilsson
    Department of General Practice and Primary Care, Faculty of Health Sciences, University of Linkoping, Sweden
    Br J Gen Pract 53:378-82. 2003
    b>Chest pain is the main symptom of first presentation with ischaemic heart disease (IHD). Little is known about the incidence of IHD among patients consulting the general practitioner (GP) for chest pain.
  38. pmc Prognostic value of CT angiography for major adverse cardiac events in patients with acute chest pain from the emergency department: 2-year outcomes of the ROMICAT trial
    Christopher L Schlett
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    JACC Cardiovasc Imaging 4:481-91. 2011
    The aim of this study was to determine the 2-year prognostic value of cardiac computed tomography (CT) for predicting major adverse cardiac events (MACE) in patients presenting to the emergency department (ED) with acute chest pain.
  39. pmc Anxiety and hypervigilance to cardiopulmonary sensations in non-cardiac chest pain patients with and without psychiatric disorders
    Kamila S White
    University of Missouri Saint Louis, Department of Psychology, Saint Louis, MO 63121, USA
    Behav Res Ther 48:394-401. 2010
    ..vigilance, cardiac anxiety, and the mediating role of interoceptive fear on pain in patients with non-cardiac chest pain (NCCP; a syndrome of chest pain in the absence of identifiable organic etiology)...
  40. doi Chest wall syndrome in primary care patients with chest pain: presentation, associated features and diagnosis
    Stefan Bösner
    Department of General Practice Family Medicine, University of Marburg, D 35043 Marburg, Germany
    Fam Pract 27:363-9. 2010
    Chest wall syndrome (CWS) is the most frequent aetiology of chest pain in a primary care setting.
  41. pmc The Chest Pain Choice trial: a pilot randomized trial of a decision aid for patients with chest pain in the emergency department
    Meghan A Pierce
    Knowledge and Encounter Research Unit, Mayo Clinic, Rochester, Minnesota, USA
    Trials 11:57. 2010
    b>Chest pain is a common presenting complaint in the emergency department (ED)...
  42. ncbi Risk prediction in patients presenting with suspected cardiac pain: the GRACE and TIMI risk scores versus clinical evaluation
    G Ramsay
    Cardiovascular Research, Division of Medical and Radiological Sciences, The University of Edinburgh, Chancellors Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    QJM 100:11-8. 2007
    Identifying which patients presenting with undifferentiated chest pain are at risk of major cardiac events is a major clinical challenge...
  43. doi Very early diagnosis of chest pain by point-of-care testing: comparison of the diagnostic efficiency of a panel of cardiac biomarkers compared with troponin measurement alone in the RATPAC trial
    Paul Collinson
    Department of Clinical Blood Sciences, St George s Hospital, Ground Floor, Jenner Wing, London SW17 0QT, UK
    Heart 98:312-8. 2012
    ..To assess the impact of triple marker testing on patient management and the diagnostic efficiencies of different biomarker strategies examined...
  44. ncbi Psychologic morbidity and health-related quality of life of patients assessed in a chest pain observation unit
    S Goodacre
    Northern General Hospital, Sheffield, United Kingdom
    Ann Emerg Med 38:369-76. 2001
    We sought to measure psychologic morbidity and health-related quality of life among patients attending the hospital with acute chest pain both at presentation and 1 month after rigorous assessment for cardiac disease.
  45. ncbi Heart fatty acid-binding protein offers similar diagnostic performance to high-sensitivity troponin T in emergency room patients presenting with chest pain
    Kenji Inoue
    Department of Cardiology, Juntendo University Nerima Hospital, Tokyo, Japan
    Circ J 75:2813-20. 2011
    ....
  46. doi Prognostic value of a multimarker approach for patients presenting to hospital with acute chest pain
    Conor J McCann
    The Heart Centre, Royal Victoria Hospital, Belfast, United Kingdom
    Am J Cardiol 103:22-8. 2009
    ..the prognostic role of novel biomarkers for the risk stratification of patients admitted with ischemic-type chest pain, a prospective study of 664 patients presenting to 2 coronary care units with ischemic-type chest pain was ..
  47. ncbi Detailed angiographic analysis of women with suspected ischemic chest pain (pilot phase data from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation [WISE] Study Angiographic Core Laboratory)
    B L Sharaf
    Rhode Island Hospital, Brown University, Providence, Rhode Island 02903, USA
    Am J Cardiol 87:937-41; A3. 2001
    ..series of women enrolled in the Women's Ischemia Syndrome Evaluation (WISE) study who had suspected ischemic chest pain. Previous studies have suggested that women with chest pain have a lower prevalence of significant coronary ..
  48. pmc Risk prediction with serial myeloperoxidase monitoring in patients with acute chest pain
    Stephen J Nicholls
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA
    Clin Chem 57:1762-70. 2011
    ..Although myeloperoxidase (MPO) monitoring is predictive for cardiovascular outcomes in suspected acute coronary syndromes, the value of serial testing is unknown...
  49. doi The prevalence and correlates of psychological outcomes in patients with acute non-cardiac chest pain: a systematic review
    Rosemary Webster
    Department of Psychology, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Emerg Med J 29:267-73. 2012
    Over 40% of patients admitted to emergency departments (ED) with chest pain receive a non-cardiac diagnosis...
  50. ncbi Chest pain presenting to the Emergency Department--to stratify risk with GRACE or TIMI?
    Richard Lyon
    Department of Emergency Medicine, Royal Infirmary, Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SA, United Kingdom
    Resuscitation 74:90-3. 2007
    ..is a need to stratify risk rapidly in patients presenting to the Emergency Department (ED) with undifferentiated chest pain. The Global Registry of Acute Coronary Events (GRACE) and the Thrombolysis in Myocardial Infarction (TIMI) ..
  51. pmc Randomised controlled trial and economic evaluation of a chest pain observation unit compared with routine care
    Steve Goodacre
    School of Health and Related Research, University of Sheffield, Sheffield S1 4DA
    BMJ 328:254. 2004
    To measure the effectiveness and cost effectiveness of providing care in a chest pain observation unit compared with routine care for patients with acute, undifferentiated chest pain.
  52. pmc Diagnostic and prognostic utility of early measurement with high-sensitivity troponin T assay in patients presenting with chest pain
    Sally J Aldous
    Christchurch Hospital, Christchurch, New Zealand
    CMAJ 184:E260-8. 2012
    ..High-sensitivity troponin assays are now available for clinical use. We investigated whether early measurement with such an assay is superior to a conventional assay in the evaluation of acute coronary syndromes...
  53. ncbi Chest pain in the emergency department: the broad spectrum of causes
    D C Knockaert
    Department of Internal Medicine, Gasthuisberg University Hospital, Leuven, Belgium
    Eur J Emerg Med 9:25-30. 2002
    We performed a prospective study to describe the broad spectrum of causes of chest pain in patients presenting to the emergency department and to compare the diagnoses in referred patients, self-referred patients and patients rushed in by ..
  54. ncbi Value and limitations of chest pain history in the evaluation of patients with suspected acute coronary syndromes
    Clifford J Swap
    Massachusetts General Hospital, Boston, MA 02114, USA
    JAMA 294:2623-9. 2005
    The chest pain history, physical examination, determination of coronary artery disease (CAD) risk factors, and the initial electrocardiogram compose the information immediately available to clinicians to help determine the probability of ..
  55. ncbi Functional esophageal disorders
    Jean Paul Galmiche
    University of Nantes, Nantes, France
    Gastroenterology 130:1459-65. 2006
    Functional esophageal disorders represent processes accompanied by typical esophageal symptoms (heartburn, chest pain, dysphagia, globus) that are not explained by structural disorders, histopathology-based motor disturbances, or ..
  56. doi Chest pain in focal musculoskeletal disorders
    Mette Jensen Stochkendahl
    Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Med Clin North Am 94:259-73. 2010
    The musculoskeletal system is a recognized source of chest pain. However, despite the apparently benign origin, patients with musculoskeletal chest pain remain under-diagnosed, untreated, and potentially continuously disabled in terms of ..
  57. doi Investigation of paramedics' compliance with clinical practice guidelines for the management of chest pain
    Ken Figgis
    Emergency Department, Mayo General Hospital, Castlebar, Mayo, UK
    Emerg Med J 27:151-5. 2010
    ..However, previous studies have indicated that paramedics' compliance with chest pain protocols is suboptimal and that many patients do not receive the benefits of appropriate prehospital treatment.
  58. doi Morbidity of DSM-IV Axis I disorders in patients with noncardiac chest pain: Psychiatric morbidity linked with increased pain and health care utilization
    Kamila S White
    University of Missouri Saint Louis, Department of Psychology, Saint Louis, MO 63121, USA
    J Consult Clin Psychol 76:422-30. 2008
    The present study examined current and lifetime psychiatric morbidity, chest pain, and health care utilization in 229 patients with noncardiac chest pain (NCCP), angina-like pain in the absence of cardiac etiology...
  59. doi Cardiac and psychiatric diagnoses among patients referred for chest pain and palpitations
    Egil Jonsbu
    Department of Psychiatry, Molde Hospital, Molde, Norway
    Scand Cardiovasc J 43:256-9. 2009
    The purpose of this study was to assess the prevalence of cardiac and psychiatric diagnoses in patients with chest pain and palpitations.
  60. ncbi Non-cardiac chest pain: predictors of health care seeking, the types of health care professional consulted, work absenteeism and interruption of daily activities
    G D Eslick
    Department of Medicine, The University of Sydney, Nepean Hospital, Penrith, New South Wales, Australia
    Aliment Pharmacol Ther 20:909-15. 2004
    To determine the predictors of health care seeking, assess the types of health care professional consulted and to calculate the work absenteeism rates and interruptions to daily activities among non-cardiac chest pain patients.
  61. ncbi Use of a whole blood rapid panel test for heart-type fatty acid-binding protein in patients with acute chest pain: comparison with rapid troponin T and myoglobin tests
    Yoshihiko Seino
    First Department of Medicine and Coronary Care Unit, Nippon Medical School, Tokyo, Japan
    Am J Med 115:185-90. 2003
    ..We sought to determine the clinical utility of a newly developed qualitative test to measure heart-type fatty acid-binding protein levels in blood for the early identification of myocardial infarction...
  62. doi Relationship between low lymphocyte count and major cardiac events in patients with acute chest pain, a non-diagnostic electrocardiogram and normal troponin levels
    Julio Nunez
    Servicio de Cardiologia, Hospital Clinico Universitario, Universitat de Valencia, Avda Blasco Ibanez 17, Valencia, Spain
    Atherosclerosis 206:251-7. 2009
    Risk stratification of patients with acute chest pain, non-diagnostic electrocardiogram and normal troponin (ACPneg) remains a challenge, partly because no standardized set of biomarkers with prognostic ability has been identified in this ..
  63. pmc The association of diabetes and older age with the absence of chest pain during acute coronary syndromes
    Holli A DeVon
    Loyola University Chicago, USA
    West J Nurs Res 30:130-44. 2008
    ..Patients with diabetes comprised 33.2% of the sample and reported significantly less chest pain and more unusual fatigue...
  64. ncbi Psychological treatments for noncardiac chest pain: recommendations for a new approach
    Jeanne L Esler
    Centers for Behavioral and Preventive Medicine, Miriam Hospital, Brown University Medical School, Coro Building, Suite 500, 1 Hoppin Street, Providence, RI 02903, USA
    J Psychosom Res 56:263-9. 2004
    ..Our objective is to describe the current state of treatment for NCCP, identify barriers to treatment and limitations of current approaches, and to recommend treatment strategies, which may address these challenges...
  65. ncbi Errors of omission in the treatment of prehospital chest pain patients
    Jon C Rittenberger
    University of Pittsburgh Affiliated Residency in Emergency Medicine and the Department of Emergency Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Prehosp Emerg Care 9:2-7. 2005
    ..sought to assess the frequency and nature of deviations from a standardized treatment protocol for the chief complaint of chest pain. They also sought to quantify any time delays in treatment of potential ischemic cardiac chest pain.
  66. doi Chest pain in primary care: epidemiology and pre-work-up probabilities
    Stefan Bösner
    Department of General Practice Family Medicine, University of Marburg, Marburg, Germany
    Eur J Gen Pract 15:141-6. 2009
    b>Chest pain is a common complaint and reason for consultation. We aimed to study the epidemiology of chest pain with respect to underlying aetiologies and to establish pre-work-up probabilities for the primary care setting.
  67. ncbi A neural computational aid to the diagnosis of acute myocardial infarction
    William G Baxt
    Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Ann Emerg Med 39:366-73. 2002
    ..presence of acute myocardial infarction in adult patients who present to the emergency department with anterior chest pain remains elusive...
  68. doi Coronary computed tomographic angiography and risk of all-cause mortality and nonfatal myocardial infarction in subjects without chest pain syndrome from the CONFIRM Registry (coronary CT angiography evaluation for clinical outcomes: an international mult
    Iksung Cho
    Division of Cardiology, Severance Cardiovascular Hospital, Seoul, South Korea
    Circulation 126:304-13. 2012
    The predictive value of coronary computed tomographic angiography (cCTA) in subjects without chest pain syndrome (CPS) has not been established...
  69. doi 2-Hour accelerated diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: the ADAPT trial
    Martin Than
    Christchurch Hospital, Christchurch, New Zealand
    J Am Coll Cardiol 59:2091-8. 2012
    The purpose of this study was to determine whether a new accelerated diagnostic protocol (ADP) for possible cardiac chest pain could identify low-risk patients suitable for early discharge (with follow-up shortly after discharge).
  70. doi Comparative diagnostic yield and 3-month outcomes of "triple rule-out" and standard protocol coronary CT angiography in the evaluation of acute chest pain
    Ryan D Madder
    Department of Cardiovascular Medicine, William Beaumont Hospital, 3601 W 13 Mile Road, Royal Oak, MI 48073, USA
    J Cardiovasc Comput Tomogr 5:165-71. 2011
    ..Triple rule-out" CT angiography simultaneously evaluates coronary artery disease, pulmonary embolism, and aortic dissection in a single imaging examination. However, the clinical outcomes of this approach are unknown...
  71. doi Considerations for early acute myocardial infarction rule-out for emergency department chest pain patients: the case of copeptin
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliera di Parma, Parma, Italy
    Clin Chem Lab Med 50:243-53. 2012
    The evaluation of patients admitted at the emergency department (ED) for chest pain is challenging and involves many different clinical specialists including emergency physicians, laboratory professionals and cardiologists...
  72. ncbi Experimental pain and psychologic status of patients with chest pain with normal coronary arteries or ischemic heart disease
    R Zachariae
    Institute of Psychology, Aarhus University, Aarhus, Denmark
    Am Heart J 142:63-71. 2001
    BACKGROUND: The cause of chest pain in patients with a normal coronary angiogram (NCA) remains an enigma. Also, it is unclear whether psychosocial factors play a role in the etiology of chest pain in these patients...
  73. pmc Time distribution of the onset of chest pain in subjects with acute ST-elevation myocardial infarction: an eight-year, single-center study in China
    En Zhi Jia
    Department of Cardiovascular Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China
    PLoS ONE 7:e32478. 2012
    The objective of this study was to explore the time distribution patterns of the onset of chest pain in subjects with acute ST-elevation myocardial infarction in a Chinese population.
  74. doi Differentiating ST-elevation myocardial infarction from nonischemic ST-elevation in patients with chest pain
    Viet Tran
    Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, Texas, USA
    Am J Cardiol 108:1096-101. 2011
    ..Broad inconsistencies existed among readers as to the chosen reasons for NISTE classification. In conclusion, we found wide variations in experienced interventional cardiologists in differentiating STEMI with a need for pPCI from NISTE...
  75. doi Patients with noncardiac chest pain and benign palpitations referred for cardiac outpatient investigation: a 6-month follow-up
    Egil Jonsbu
    Department of Psychiatry, Molde Hospital, 6407 Molde, Norway
    Gen Hosp Psychiatry 32:406-12. 2010
    The aims were to (a) study the characteristics and outcome in patients with noncardiac chest pain or benign palpitations referred for cardiac evaluation, (b) compare psychological characteristics in the two groups, (c) identify predictors ..
  76. doi The independent association of anxiety with non-cardiac chest pain
    Loes Smeijers
    a Department of Medical and Clinical Psychology, Center of Research on Psychology in Somatic diseases CoRPS, Tilburg University, The Netherlands
    Psychol Health 29:253-63. 2014
    Non-cardiac chest pain (NCCP) is common in clinical cardiology. Anxiety is an important factor in NCCP because of its role in the neurobehavioural processes of pain regulation...
  77. ncbi Relation between peripheral vascular endothelial function and coronary flow reserve in patients with chest pain and normal coronary angiogram
    Chul Soo Park
    Int J Cardiol 113:118-20. 2006
    ..the intima-media thickness (IMT) of the carotid artery in 32 subjects (mean age 58+/-9 years, M/F=9:23 ) with chest pain and normal coronary angiogram. The subjects were divided into 2 groups according to CFR >or=2.1 or <2...
  78. doi Heart rate variability risk score for prediction of acute cardiac complications in ED patients with chest pain
    Marcus Eng Hock Ong
    Department of Emergency Medicine, Singapore General Hospital, Outram Road, Singapore 169608
    Am J Emerg Med 31:1201-7. 2013
    ..a risk score incorporating heart rate variability (HRV) and traditional vital signs for the prediction of early mortality and complications in patients during the initial presentation to the emergency department (ED) with chest pain.
  79. ncbi The effect of an empirical trial of high-dose lansoprazole on symptom response of patients with non-cardiac chest pain--a randomized, double-blind, placebo-controlled, crossover trial
    J Bautista
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System, 3601 S 6th Avenue, Tucson, AZ 85723, USA
    Aliment Pharmacol Ther 19:1123-30. 2004
    Empirical trial with high-dose omeprazole has been shown to be a sensitive tool for diagnosing patients with gastro-oesophageal reflux disease-related non-cardiac chest pain.
  80. doi Growth differentiation factor-15 in the early diagnosis and risk stratification of patients with acute chest pain
    Nora Schaub
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    Clin Chem 58:441-9. 2012
    ..Growth differentiation factor-15 (GDF-15) is a stress-responsive marker that might aid in the early diagnosis and risk stratification of patients with suspected acute myocardial infarction (AMI)...
  81. ncbi A simple score for predicting coronary artery disease in patients with chest pain
    E B Wu
    Cardiothoracic Centre, Guy s and St Thomas Hospitals, London
    QJM 98:803-11. 2005
    We have previously derived a chest pain score by comparing those with and without coronary artery disease on angiography, which was subsequently validated in patients attending coronary angiography.
  82. pmc Social and gender variation in the prevalence, presentation and general practitioner provisional diagnosis of chest pain
    H Richards
    Department of General Practice, University of Glasgow, 4 Lancaster Crescent, Glasgow G12 ORR
    J Epidemiol Community Health 54:714-8. 2000
    To describe the prevalence of Rose angina and non-exertional chest pain in men and women in socioeconomically contrasting areas; to describe the proportions of men and women who present with the symptom of chest pain and who receive a ..
  83. ncbi Treatment needs of patients admitted for acute chest pain
    R A Mayou
    Department of Psychiatry, Warneford Hospital, University of Oxford, UK
    J Psychosom Res 53:1177-83. 2002
    To examine the characteristics, subsequent resource use and outcome of a consecutive cohort of admissions with acute chest pain not due to myocardial infarction.
  84. pmc Stress CMR imaging observation unit in the emergency department reduces 1-year medical care costs in patients with acute chest pain: a randomized study for comparison with inpatient care
    Chadwick D Miller
    Department of Emergency Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina 27357, USA
    JACC Cardiovasc Imaging 4:862-70. 2011
    ..direct cost of medical care and clinical events during the first year after patients with intermediate risk acute chest pain were randomized to stress cardiac magnetic resonance (CMR) observation unit (OU) testing versus inpatient care.
  85. pmc Low-risk patients with chest pain in the emergency department: negative 64-MDCT coronary angiography may reduce length of stay and hospital charges
    Janet M May
    Department of Radiology, University of Washington School of Medicine, 1959 NE Pacific St, RR210, Box 357115, Seattle, WA 98195, USA
    AJR Am J Roentgenol 193:150-4. 2009
    The current standard-of-care workup of low-risk patients with chest pain in an emergency department takes 12-36 hours and is expensive...
  86. pmc PAPP-A as a marker of increased long-term risk in patients with chest pain
    Peter A Kavsak
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
    Clin Biochem 42:1012-8. 2009
    ..The present study examined whether PAPP-A measured in an emergency department (ED) chest pain population in association with conventional and novel high sensitivity cTn (hs-cTnI) assays can predict long-..
  87. doi Severe coronary tortuosity or myocardial bridging in patients with chest pain, normal coronary arteries, and reversible myocardial perfusion defects
    Nicola Gaibazzi
    Division of Cardiology, Parma University Hospital, Italy
    Am J Cardiol 108:973-8. 2011
    ..angiograms enrolled in the SPAM contrast stress echocardiographic diagnostic study in which 400 patients with chest pain syndrome of suspected cardiac origin with a clinical indication to coronary angiography were enrolled...
  88. pmc Coronary computed tomography angiography for early triage of patients with acute chest pain: the ROMICAT (Rule Out Myocardial Infarction using Computer Assisted Tomography) trial
    Udo Hoffmann
    Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 53:1642-50. 2009
    This study was designed to determine the usefulness of coronary computed tomography angiography (CTA) in patients with acute chest pain.
  89. ncbi Evaluation of symptom index in identifying gastroesophageal reflux disease-related noncardiac chest pain
    Roy Dekel
    Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Science Center, 3601 S 6th Avenue, Tucson, AZ 85723, USA
    J Clin Gastroenterol 38:24-9. 2004
    ..lt;4), has been suggested as a measure to improve diagnosis of gastroesophageal reflux (GER)-related noncardiac chest pain (NCCP)...
  90. doi Cost-effectiveness of coronary computed tomography and cardiac stress imaging in the emergency department: a decision analytic model comparing diagnostic strategies for chest pain in patients at low risk of acute coronary syndromes
    Virginia L Priest
    Centre for Applied Health Economics, School of Medicine, Griffith University, Brisbane, Queensland, Australia
    JACC Cardiovasc Imaging 4:549-56. 2011
    Emergency department presentations with chest pain are expensive and often unrelated to coronary artery disease (CAD)...
  91. doi Usefulness of 64-slice multidetector computed tomography as an initial diagnostic approach in patients with acute chest pain
    Sung A Chang
    Division of Cardiology, Cardiovascular Center, Seoul National University Bundang Hospital, Seoul, Republic of Korea
    Am Heart J 156:375-83. 2008
    ..However, the role of MDCT as part of the initial diagnostic for evaluating acute chest pain is less well established.
  92. ncbi Costochondritis: diagnosis and treatment
    Anne M Proulx
    Wright State University Boonshoft School of Medicine, Dayton, Ohio, USA
    Am Fam Physician 80:617-20. 2009
    ..is usually self-limited and benign, it should be distinguished from other, more serious causes of chest pain. Coronary artery disease is present in 3 to 6 percent of adult patients with chest pain and chest wall ..
  93. pmc Accuracy of general practitioners' assessment of chest pain patients for coronary heart disease in primary care: cross-sectional study with follow-up
    Stefan Bösner
    Department of General Practice Family Medicine, University of Marburg, D 35043 Marburg, Germany
    Croat Med J 51:243-9. 2010
    To estimate how accurately general practitioners' (GP) assessed the probability of coronary heart disease in patients presenting with chest pain and analyze the patient management decisions taken as a result.
  94. pmc Emergency department and office-based evaluation of patients with chest pain
    Michael C Kontos
    Department of Internal Medicine, Cardiology Division, Virginia Commonwealth University, Richmond, USA
    Mayo Clin Proc 85:284-99. 2010
    The management of patients with chest pain is a common and challenging clinical problem...
  95. doi Cost-effectiveness of coronary CT angiography versus myocardial perfusion SPECT for evaluation of patients with chest pain and no known coronary artery disease
    James K Min
    Departments of Medicine and Radiology, Weill Medical College of Cornell University and The New York Presbyterian Hospital, 520 E 70th St, Room K415, New York, NY 10021, USA
    Radiology 254:801-8. 2010
    To evaluate the cost-effectiveness of diagnostic strategies for individuals with chest pain without known coronary artery disease (CAD) in the Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive ..
  96. pmc Chest wall syndrome among primary care patients: a cohort study
    François Verdon
    Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, Switzerland
    BMC Fam Pract 8:51. 2007
    The epidemiology of chest pain differs strongly between outpatient and emergency settings. In general practice, the most frequent cause is the chest wall pain...
  97. doi Usefulness of computed tomographic coronary angiography in patients with acute chest pain with and without high-risk features
    Benjamin J W Chow
    Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Am J Cardiol 106:463-9. 2010
    ..tomographic coronary angiography (CTA) and its ability to direct revascularization in patients with acute chest pain syndrome (ACPS) was investigated...
  98. ncbi Chest pain, palpitations and panic
    R Mayou
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    J Psychosom Res 44:53-70. 1998
    b>Chest pain and palpitations are commonly described in the general population and are frequent presenting symptoms in all medical settings...
  99. doi High-risk chief complaints I: chest pain--the big three
    Kar mun C Woo
    Department of Emergency Medicine, Boston Medical Center, Dowling 1 South, 1 Boston Medical Center Place, Boston, MA 02118, USA
    Emerg Med Clin North Am 27:685-712, x. 2009
    b>Chest pain is one of the most frequently seen chief complaints in patients presenting to emergency departments, and is considered to be a "high-risk" chief complaint...
  100. doi Negative ECG-gated cardiac CT in patients with low-to-moderate risk chest pain in the emergency department: 1-year follow-up
    William P Shuman
    Department of Radiology, University of Washington School of Medicine, Seattle, WA 98195, USA
    AJR Am J Roentgenol 195:923-7. 2010
    ..of this article is to determine the frequency of adverse cardiac events during the year following a negative cardiac CT angiogram in a population of patients presenting to the emergency department with low-to-moderate risk chest pain.
  101. pmc Accuracy of symptoms and signs for coronary heart disease assessed in primary care
    Stefan Bösner
    Department of General Practice Family Medicine, University of Marburg, Germany
    Br J Gen Pract 60:e246-57. 2010
    Diagnosing the aetiology of chest pain is challenging. There is still a lack of data on the diagnostic accuracy of signs and symptoms for acute coronary events in low-prevalence settings.

Research Grants62

  1. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..This prompt response to the onset of chest pain coupled with the widespread use of statins and other drugs have reversed the incidence of ST elevation/nonST ..
  2. Novel Biomarkers in Aortic Aneurysms and Acute Aortic Dissection
    JENNIFER E contact VAN EYK; Fiscal Year: 2010
    ..patients with known aortic aneurysms (ii) facilitate diagnosis of aortic dissection in the patient with acute chest pain and (iii) helps us to individualize therapy...
  3. Surgical Revascularization's Impact on Mitochondria in Hibernating Myocardium
    ROSEMARY FRANCES KELLY; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Patients with episodic chest pain prior to a heart attack suffer less damage to the heart than individuals presenting with the same type of heart ..
  4. Excitability of afferents evoking the exercise pressor reflex
    Victor Ruiz-Velasco; Fiscal Year: 2013
    ..In hearts whose coronary arteries are narrowed by disease, this vasoconstriction can cause chest pain and fatal arrhythmias...
  5. Computer Simulation of Acute Coronary Syndrome Care in the Emergency Department
    DANIEL JOSEPH FRANCE; Fiscal Year: 2010
    ..b>Chest pain prompts over 5...
  6. Molecular Imaging of Ischemic Memory with Ultrasound - Transition to Humans
    Jonathan R Lindner; Fiscal Year: 2010
    ..In patients who present with acute or recent chest pain but who have a non-diagnostic ECG, it may be possible to improve and expedite the diagnosis of acute coronary ..
  7. The Fat1 Cadherin in Atherosclerotic Vascular Disease
    NICHOLAS E SIBINGA; Fiscal Year: 2013
    ..atherosclerosis, vascular obstruction, and impaired blood flow, and lead to such very common diseases as angina (chest pain), heart failure, stroke, limb loss due to impaired circulation, and death...
  8. Role of the TRPV1 channel in myocardial salvage from ischemia-reperfusion injury
    ERIC RICHARD GROSS; Fiscal Year: 2012
    ..This may suggest that the chest pain (angina) actually is a natural pathway to protect from heart attack injury...
  9. PROMISE Trial: Clinical Coordinating Center
    Pamela Susan Douglas; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Millions of Americans develop chest pain suggestive of coronary heart disease each year and often require non-invasive diagnostic testing...
  10. PROMISE Trial: EQOL Coordinating Center
    Daniel B Mark; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Millions of Americans develop chest pain suggestive of coronary heart disease each year and often require non-invasive diagnostic testing...
  11. PROMISE Trial: SDCC
    Kerry L Lee; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Millions of Americans develop chest pain suggestive of coronary heart disease each year and often require non-invasive diagnostic testing...
  12. Metabolic Profiling of Acute Myocardial Injury in Humans
    GREGORY DYER LEWIS; Fiscal Year: 2012
    ..diagnostic utility of these novel metabolic biomarkers in patients presenting to the emergency department with chest pain. Specific Aim 4 will be to extend metabolic profiling beyond ischemia to identify metabolic modulators of ..
  13. Solutions for Vertigo presentations in the Emergency Department (SOLVE) Project
    KEVIN ANTHONY KERBER; Fiscal Year: 2012
    ..Dizziness presentations are different from other common diagnostic dilemmas (e.g., chest pain and headache presentations) because no laboratory, electrophysiological, or neuro-imaging test is a valid and ..
  14. Genesis of Esophageal Pain: Longitudinal Muscle Spasm and Wall Ischemia
    Ravinder K Mittal; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Seventy percent of patients coming to the emergency room with chest pain have normal coronary arteries and thus have non-cardiac pain. Esophagus is suspected to be the cause of pain in these patients...
  15. ROMICAT II - CCC - Lead Application
    Udo Hoffmann; Fiscal Year: 2013
    This application represents the Clinical Coordinating Center of the overall proposal. Patients with acute chest pain and normal or non-diagnostic electrocardiograms (ECGs) represent a cohort whose management is notably inefficient and ..
  16. Rule-Out Myocardial Infarction Using Computed Assisted Tomography-ROMICATII,DCC
    DAVID ALAN SCHOENFELD; Fiscal Year: 2012
    This application represents the Clinical Coordinating Center of the overall proposal. Patients with acute chest pain and normal or non-diagnostic electrocardiograms (ECGs) represent a cohort whose management is notably inefficient and ..
  17. PROMISE Trial: Dx Core
    Udo Hoffmann; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Millions of Americans develop chest pain suggestive of coronary heart disease each year and often require non-invasive diagnostic testing...
  18. Stents and Antiplatelet Drugs: Impact on Ischemia and Bleeding in the Elderly
    Samip Vasaiwala; Fiscal Year: 2011
    ..conventional technique in both the emergency setting of a heart attack as well as more routine therapy to reduce chest pain. In general, there are two types of coronary stents: drug-coated (or drug-eluting stents, DES) and non-drug- ..
  19. Spinal glia activation in chronic stress-induced visceral hyperalgesia
    Sylvie Bradesi; Fiscal Year: 2013
    ..may be generalized to many other stress-sensitive pain conditions, including interstitial cystitis, non-cardiac chest pain and fibromyalgia...
  20. Discovery &Application of Proteomics-Based Biomarkers of Early Myocardial Injury
    Marc S Sabatine; Fiscal Year: 2012
    ..Second, we examine whether measurement of the biomarkers in patients presenting to the Emergency Department with chest pain improves our ability to discriminate between non-ischemic chest pain versus unstable angina...
  21. CMR-IMPACT
    CHADWICK DAVID MILLER; Fiscal Year: 2013
    ..goal, we propose a clinical trial (n=312) involving emergency department patients with intermediate to high-risk chest pain and detectable to minimally elevated serum troponin within 6 hours of evaluation...
  22. Metabolomic Biomarkers of Early Myocardial Injury
    Marc S Sabatine; Fiscal Year: 2013
    ..Second, we examine whether measurement of the biomarkers in patients presenting to the Emergency Department with chest pain improves our ability to discriminate between non-ischemic chest pain versus unstable angina...
  23. Ultrasound-Targeted Therapy for Acute Myocardial Infarction
    Sanjiv Kaul; Fiscal Year: 2013
    ..24 hr a day call, the chances of opening an infarct-related artery (IRA) within 90-120 minutes of the onset of chest pain is 85%...
  24. The mechanics of symptom generation in dysphagia
    John E Pandolfino; Fiscal Year: 2013
    ..proposal focuses on the relationship between IBP and EGJ compliance as it relates to symptoms of dysphagia and chest pain. Thus, the goals of this proposal are:1) to define the physiologic relationship between IBP and EGJ compliance, ..
  25. Non-invasive detection of heart transplant rejection with MRI
    NEIL RANJAN CHATTERJEE; Fiscal Year: 2013
    ..Because heart transplant patients lack innervation of the heart, they do not experience the chest pain usually associated with infarct allowing CAV to progress un- noticed...
  26. ESOPHAGEAL MOTOR FUNCTION IN HEALTH AND DISEASE
    REZA NONE SHAKER; Fiscal Year: 2012
    ..such as those found in non-erosive reflux disease (NERD), functional heartburn (FH) and pain in non-cardiac chest pain (NCCP) poses a significant clinical challenge...
  27. PROMISE Trial: Substudy to Assess for Effective Dose of Radiation
    ANDREW EINSTEIN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Millions of Americans develop chest pain suggestive of coronary artery disease (CAD) each year and often receive non-invasive diagnostic testing such as myocardial perfusion scintigraphy (MPS) or, ..
  28. Fractional flow reserve measurement based on coronary angiographic images
    SABEE Y MOLLOI; Fiscal Year: 2010
    ..stenosis), where angiography is very limited in distinguishing whether a coronary lesions is the cause of chest pain. Because of the major limitations of standard coronary arteriography, a method for functional measure of ..
  29. Cardiovascular Imaging in Ischemic Heart Disease
    Udo Hoffmann; Fiscal Year: 2013
    ..in the Framingham Heart Study, 2) Comparing Competing Diagnostic Strategies to Triage Patients with Acute Chest Pain in the ED - A Randomized Diagnostic Multicenter Trial with the major goal to determine whether cardiac CT is ..
  30. Cardiovascular Regenerative Medicine
    DOUGLAS EUGENE VAUGHAN; Fiscal Year: 2013
    ..in patients with chronic, refractory ischemia: patients with intractable angina had significant reductions in chest pain and improved exercise tolerance, while patients with critical limb ischemia had reduced amputation rates...
  31. Esophageal Mast Cell Nerve Interactions
    Shaoyong Yu; Fiscal Year: 2013
    Abnormal esophageal sensations, such as esophageal-related noncardiac chest pain and heartburn, are common complaints. The underlying mechanism of such esophageal nociception remains unclear...
  32. MVPS: Health Concerns, Role function, Health Service Use
    KRISTINE SCORDO; Fiscal Year: 2002
    ..Anecdotal reports by individuals with MVPS indicate a variety of frightening symptoms, including chest pain, shortness of breath, palpitations, migraine headaches, lightheadedness, fatigue, dizziness on standing, mood ..
  33. Targeted Nanoparticles of Bismuth Organo Complexes for Spectral CT Imaging of Cor
    Y Andrew Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chest pain in patients presenting to the emergency department (ED) present a clinical dilemma: transfer for emergent coronary revascularization, admit overnight for cardiac telemetry and stress ..
  34. FACSVantage SE Upgrade
    RAYMOND HESTER; Fiscal Year: 2004
    ..10) role of activated leukocyte cell adhesion molecule and activated monocytes in the pathogenesis of acute chest pain, 11) role of erythrocyte-endothelial cell adhesion in acute lung injury in sickle cell disease, 12) chrondrocyte ..
  35. PAIN AND BETA-ENDORPHIN RESPONSES IN MEN AND WOMEN
    David Sheps; Fiscal Year: 2001
    ..in patients with stable angina, and in individuals without evidence of coronary artery disease and no chest pain. The following specific aims will be tested: (1) Women will exhibit greater sensitivity to thermal, ischemic, ..
  36. Multi-analyte Biosensor for Emerging Cardiac Markers
    CHARLES PENNINGTON; Fiscal Year: 2001
    ..researchers and physicians to improve evaluation and triage of patients reporting to emergency departments with chest pain. New point-of-care diagnostic technologies designed for rapid quantification of conventional markers including, ..
  37. DIAGNOSIS OF CHEST PAIN AND CARE IN RURAL HOSPITALS
    John Westfall; Fiscal Year: 2000
    ..abstract_text> ..
  38. Improved MR Techniques for Coronary Artery Imaging
    Craig H Meyer; Fiscal Year: 2010
    ..These new methods are designed to detect and evaluate coronary artery disease, which causes chest pain and heart attacks...
  39. GDNF in the Enteric Nervous System
    Yun Xia; Fiscal Year: 2007
    ..nervous system that may be manifest as the irritable bowel syndrome (IBS), nonulcer dyspepsia or non-cardiac chest pain. The research is directed to understanding the role of glial derived neurotropic factor (GDNF) in the enteric ..
  40. Development of Platelet & Coagulation Activation Assays
    RONALD SHEBUSKI; Fiscal Year: 2001
    ..e. emergency room/chest pain unit) if the patient is indeed experiencing a thrombus-dependent acute myocardial infarct...
  41. ASSESSING THE VARIABILITY IN TIME TO TREATMENT IN SURGER
    Mark Chassin; Fiscal Year: 2001
    ..g., time from injury to hospital; time from onset of chest pain to emergency room door)...
  42. TREE-STRUCTURED STATISTICAL METHODS
    Richard Olshen; Fiscal Year: 1993
    ..patients who enter the emergency room with chief complaint of acute chest pain. Particular improvements and new capabilities to existing algorithms include but are not limited to time series ..
  43. CARDIAC PROCEDURE USE: A PROSPECTIVE COHORT STUDY
    Paula Johnson; Fiscal Year: 1999
    ..the appropriateness and necessity of cardiac procedures for a cohort of 3,400 patients presenting with acute chest pain in an emergency department...
  44. NOVEL ESOPHAGEAL MOTOR FUNCTION ASSESSMENT SYSTEM
    JianFeng Chen; Fiscal Year: 2006
    ..Typical esophageal motor disorders include dysphasia, gastroesophageal reflux disease (GERD), non-cardiac chest pain, etc...
  45. MECHANISMS OF ACTIVATION OF CARDIAC NOCICEPTORS
    Hui Lin Pan; Fiscal Year: 2005
    ..role of ET-1 and prostaglandins in activation of cardiac nociceptors and elaborating the perception of chest pain in patients with myocardial ischemia...
  46. ANXIETY, DEPRESSION, AND NONCARDIAC CHEST PAIN
    Francis Keefe; Fiscal Year: 2005
    APPLICANT'S DESCRIPTION: Persistent pain is a significant problem for many non-cardiac chest pain patients...
  47. HEART ATTACK SURVIVAL KIT PROJECT
    Mickey Eisenberg; Fiscal Year: 2003
    ..Also unique is the inclusion of an aspirin in the kit. Data on 911 calls for chest pain and self-administration of aspirin will be collected from the medical incident report forms (MIRF), completed by ..
  48. New ECG Criteria for Posterior Myocardial Infarction
    Shu Fen Wung; Fiscal Year: 2004
    ..Currently, standard 12-lead ECGs are obtained on all patients presenting to the ED with chest pain. The 12-lead ECG has been useful in the diagnosis of acute anterior and inferior MI's, however standard 12-leads ..
  49. Sequist:Can Risk Score Alerts Improve Office Care for Chest Pain?
    THOMAS SEQUIST; Fiscal Year: 2009
    The evaluation of ambulatory patients with chest pain is a challenging and serious problem, accounting for a significant proportion of all outpatient visits...
  50. COMPLEMENT AND LEUKOCYTES IN MYOCARDIAL INFARCTION
    ROGER ROSSEN; Fiscal Year: 1991
    ..frequently detected in sera of patients with myocardial infarction but only rarely in sera of controls who have chest pain without infarction...
  51. IMPROVED VASODILATORS FOR PHARMACOLOGICAL STRESS IMAGING
    George Beller; Fiscal Year: 2000
    ..Currently used agents, adenosine or dipyridamole, cause a significant number of adverse side effects including chest pain, A-V conduction block, hypotension, and bronchospasm...
  52. SMOKING CESSATION IN THE CHEST PAIN OBSERVATION UNIT
    Beth Bock; Fiscal Year: 2002
    Approximately 4.5 million Americans visit the emergency department each year with symptoms of chest pain. Over 90% are eventually ruled out for myocardial infarction and other acute cardiovascular events...
  53. Detection of cardiac ischemia using magnetocardiography
    MARK DIIORIO; Fiscal Year: 2007
    ..b>Chest pain is the second leading cause of admission in emergency rooms in the U...
  54. PSYCHOPHYSIOLOGICAL INTERACTIONS--NON-CARDIAC CHEST PAIN
    LAURENCE BRADLEY; Fiscal Year: 2001
    Approximately 75,000-150,000 patients each year in the United States are identified as suffering from chest pain of unknown etiology (CP)...
  55. OUTCOMES OF MANAGEMENT STRATEGIES FOR CHEST PAIN
    Thomas Lee; Fiscal Year: 1993
    ..These analyses will provide important insights into the impact of different mangement strategies on patient outcomes and resource utilization...
  56. Prediction of Cardiomyopathy in Type I Diabetes by MRS
    Gerald Pohost; Fiscal Year: 2007
    ..decrease in cardiac phosphocreatine (PCr)/ATP with handgrip stress, indicative of ischemia, in women with chest pain but no artery disease. The most likely explanation for these results was the presence of microvascular disease...
  57. Integrated Myocardial Ischemia Assessment with MRI
    John Pauly; Fiscal Year: 2006
    Patients with chest pain suffer from inadequate blood supply to the heart. This "myocardial ischemia" is reflected in changes in many physiologic parameters, including coronary flow reserve and myocardial contractile reserve...
  58. PATIENT-CENTERED CARE AND MYOCARDIAL INFARCTION OUTCOMES
    Allen Fremont; Fiscal Year: 2002
    ..during hospitalization had worse self-reported health status and were more likely than other patients to report chest pain 1 year after their AMI...
  59. Tc-99m Glucarate for chest pain triage in emergency room.
    KOON PAK; Fiscal Year: 2009
    Differentiating acute coronary syndrome (ACS) from noncardiac chest pain is the primary diagnostic challenge for clinicians in the emergency department...
  60. IMMUNOPATHWAYS IN ACUTE CORONARY SYNDROMES
    Cornelia Weyand; Fiscal Year: 2005
    ..develop acute coronary syndromes and to risk-stratify patients presenting in the emergency room with acute onset chest pain. The clinical significance of these two specific aims stems from the potential to identify a novel prognostic ..
  61. EPIDEMIOLOGY OF CORONARY HEART DISEASE IN BLACKS
    Lucile Adams Campbell; Fiscal Year: 1992
    ..S. blacks. Among patients with acute myocardial infarction who often present with typical ischemic chest pain, it has been shown that blacks present more often without cheat pain when compared to whites and hispanics...
  62. GENDER DIFFERENCES IN PATTERNS OF CHRONIC ANGINAL PAIN
    Laura Kimble; Fiscal Year: 2001
    ..symptom experience including how patterns of angina change over time, the effect of gender on patterns of chest pain, and relationships among gender, patterns of chest pain and quality of life...