abdominal pain

Summary

Summary: Sensation of discomfort, distress, or agony in the abdominal region; generally associated with functional disorders, tissue injuries, or diseases.

Top Publications

  1. doi Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation
    Jeffrey M Johnston
    Ironwood Pharmaceuticals, Inc, Cambridge, Massachusetts, USA
    Gastroenterology 139:1877-1886.e2. 2010
  2. ncbi Chronic Abdominal Pain In Children: a Technical Report of the American Academy of Pediatrics and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
    Carlo Di Lorenzo
    J Pediatr Gastroenterol Nutr 40:249-61. 2005
  3. doi Expression of the TRPV1 receptor differs in quiescent inflammatory bowel disease with or without abdominal pain
    Ayesha Akbar
    Department of Gastroenterology, Imperial College London, UK
    Gut 59:767-74. 2010
  4. ncbi Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
    Giovanni Barbara
    Departmentof Internal Medicine and Gastroenterology, and CRBA, University of Bologna, Italy
    Gastroenterology 126:693-702. 2004
  5. ncbi Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea
    W Y Chey
    Rochester Institute for Digestive Diseases and Sciences, University of Rochester Medical Center, New York 14607, USA
    Am J Gastroenterol 96:1499-506. 2001
  6. pmc Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain
    A Akbar
    Department of Gastroenterology, Imperial College London, UK
    Gut 57:923-9. 2008
  7. pmc Strongyloides stercoralis is a cause of abdominal pain, diarrhea and urticaria in rural Cambodia
    Virak Khieu
    National Centre for Parasitology, Entomology and Malaria Control, Ministry of Health, Phnom Penh, Cambodia
    BMC Res Notes 6:200. 2013
  8. ncbi Quality of life for children with functional abdominal pain: a comparison study of patients' and parents' perceptions
    Nader N Youssef
    Center for Pediatric Functional Gastrointestinal and Motility Disorders, Goryeb Children s Hospital Atlantic Health System, Morristown, NJ 07962, USA
    Pediatrics 117:54-9. 2006
  9. pmc Functional abdominal pain in childhood and long-term vulnerability to anxiety disorders
    Grace D Shelby
    Department of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA
    Pediatrics 132:475-82. 2013
  10. pmc Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study
    G H Song
    Department of Medicine, National University of Singapore
    Gut 54:1402-7. 2005

Research Grants

Detail Information

Publications412 found, 100 shown here

  1. doi Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation
    Jeffrey M Johnston
    Ironwood Pharmaceuticals, Inc, Cambridge, Massachusetts, USA
    Gastroenterology 139:1877-1886.e2. 2010
    ..We assessed the efficacy and safety of linaclotide at a daily dose range of 75-600 μg in IBS-C...
  2. ncbi Chronic Abdominal Pain In Children: a Technical Report of the American Academy of Pediatrics and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
    Carlo Di Lorenzo
    J Pediatr Gastroenterol Nutr 40:249-61. 2005
    Chronic abdominal pain, defined as long-lasting intermittent or constant abdominal pain, is a common pediatric problem encountered by primary care physicians, medical subspecialists and surgical specialists...
  3. doi Expression of the TRPV1 receptor differs in quiescent inflammatory bowel disease with or without abdominal pain
    Ayesha Akbar
    Department of Gastroenterology, Imperial College London, UK
    Gut 59:767-74. 2010
    ..A significant proportion of patients with inflammatory bowel disease (IBD) continue to complain of abdominal pain despite their disease being otherwise quiescent...
  4. ncbi Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
    Giovanni Barbara
    Departmentof Internal Medicine and Gastroenterology, and CRBA, University of Bologna, Italy
    Gastroenterology 126:693-702. 2004
    The mechanisms underlying abdominal pain perception in irritable bowel syndrome (IBS) are poorly understood. Intestinal mast cell infiltration may perturb nerve function leading to symptom perception...
  5. ncbi Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea
    W Y Chey
    Rochester Institute for Digestive Diseases and Sciences, University of Rochester Medical Center, New York 14607, USA
    Am J Gastroenterol 96:1499-506. 2001
    ..We have investigated motility patterns in IBS patients with abdominal pain and frequent defecation or diarrhea and in healthy volunteers...
  6. pmc Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain
    A Akbar
    Department of Gastroenterology, Imperial College London, UK
    Gut 57:923-9. 2008
    ..In irritable bowel syndrome (IBS), abdominal pain is a common and distressing symptom where the pathophysiology is still not clearly defined...
  7. pmc Strongyloides stercoralis is a cause of abdominal pain, diarrhea and urticaria in rural Cambodia
    Virak Khieu
    National Centre for Parasitology, Entomology and Malaria Control, Ministry of Health, Phnom Penh, Cambodia
    BMC Res Notes 6:200. 2013
    ..stercoralis (more than 250 larvae in a single Baermann test) from a community in rural Cambodia, both before and three weeks after ivermectin (200 μg/kg BW, single oral dose) treatment...
  8. ncbi Quality of life for children with functional abdominal pain: a comparison study of patients' and parents' perceptions
    Nader N Youssef
    Center for Pediatric Functional Gastrointestinal and Motility Disorders, Goryeb Children s Hospital Atlantic Health System, Morristown, NJ 07962, USA
    Pediatrics 117:54-9. 2006
    Children with chronic abdominal pain of nonorganic origin, termed functional abdominal pain (FAP), experience school absences and social withdrawal and report impaired physical ability...
  9. pmc Functional abdominal pain in childhood and long-term vulnerability to anxiety disorders
    Grace D Shelby
    Department of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA
    Pediatrics 132:475-82. 2013
    Cross-sectional studies link functional abdominal pain (FAP) to anxiety and depression in childhood, but no prospective study has evaluated psychiatric status in adulthood or its relation to pain persistence.
  10. pmc Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study
    G H Song
    Department of Medicine, National University of Singapore
    Gut 54:1402-7. 2005
    ..We aimed to determine if melatonin was effective in improving bowel symptoms and sleep disturbances in irritable bowel syndrome (IBS) patients with sleep disturbance...
  11. pmc The role of routine assays of serum amylase and lipase for the diagnosis of acute abdominal pain
    Paul A Sutton
    Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre Biomedical Research Unit, Nottingham University Hospitals, Queen s Medical Centre, Nottingham, UK
    Ann R Coll Surg Engl 91:381-4. 2009
    We aimed to evaluate the role of routine measurements of serum amylase and lipase in the diagnosis of acute abdominal pain.
  12. pmc Childhood nonspecific abdominal pain in family practice: incidence, associated factors, and management
    Marieke J Gieteling
    Department of General Practice, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Ann Fam Med 9:337-43. 2011
    Nonspecific abdominal pain (NSAP) is a common complaint in childhood. In specialist care, childhood NSAP is considered to be a complex and time-consuming problem, and parents are hard to reassure...
  13. ncbi Anxiety and psychosocial stress as predictors of headache and abdominal pain in urban early adolescents
    Kamila S White
    Department of Psychology, University of Missouri Saint Louis, 63121 4499, USA
    J Pediatr Psychol 31:582-96. 2006
    To examine the relations among anxiety, psychosocial stress, and headache and abdominal pain complaints within the context of the Biobehavioral Model of Pediatric Pain.
  14. ncbi Mucosal mast cell counts correlate with visceral hypersensitivity in patients with diarrhea predominant irritable bowel syndrome
    Jung Ho Park
    Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Gastroenterol Hepatol 21:71-8. 2006
    ..Our aim was to determine whether a relationship exists between the number of mucosal mast cells in the gut and visceral hypersensitivity...
  15. ncbi Sleep characteristics of youth with functional abdominal pain and a healthy comparison group
    Edward D Huntley
    Children s National Medical Center, 111 Michigan Avenue, N W, Washington, DC 20010 2970, USA
    J Pediatr Psychol 32:938-49. 2007
    To describe sleep problems among youth with and without functional abdominal pain (FAP).
  16. pmc Development of functional gastrointestinal disorders after Giardia lamblia infection
    Kurt Hanevik
    Institute of Medicine, University of Bergen, Bergen, Norway
    BMC Gastroenterol 9:27. 2009
    ..This study aims to characterize persistent abdominal symptoms elicited by Giardia infection according to Rome II criteria and symptoms scores...
  17. ncbi Wandering spleen with chronic torsion
    Takeyuki Misawa
    Department of Surgery, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Am J Surg 195:504-5. 2008
    ..Owing to the symptomatic splenomegaly with hypersplenism and chronic torsion, laparoscopic splenectomy was performed...
  18. ncbi Computed tomographic and magnetic resonance features of gynecologic abnormalities in women presenting with acute or chronic abdominal pain
    Grace M Kalish
    Department of Radiology, University of Washington School of Medicine, Seattle, WA 98104 2499, USA
    Ultrasound Q 23:167-75. 2007
    ..The purpose of this review is to present a series of commonly encountered gynecologic abnormalities with either CT or MR to make radiologists more familiar with gynecologic pathology on CT and MRI...
  19. doi Pancreatic neuropathy results in "neural remodeling" and altered pancreatic innervation in chronic pancreatitis and pancreatic cancer
    Güralp Onur Ceyhan
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich D 81675, Germany
    Am J Gastroenterol 104:2555-65. 2009
    ..The aim of this study was to identify the influence of these neuropathic changes on the quality of pancreatic innervation, intrapancreatic glia, and visceral pain...
  20. doi Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrome
    Cesare Cremon
    Department of Clinical Medicine and Center for Applied Biomedical Research, University of Bologna, Bologna, Italy
    Am J Gastroenterol 106:1290-8. 2011
    ....
  21. ncbi Costs of health care for irritable bowel syndrome, chronic constipation, functional diarrhoea and functional abdominal pain
    K A Nyrop
    Center for Functional Gastrointestinal and Motility Disorders, University of North Carolina, Chapel Hill, NC 27599 7080, USA
    Aliment Pharmacol Ther 26:237-48. 2007
    ..To provide estimates of actual costs to deliver health care to patients with functional bowel disorders, and to assess the cost impact of symptom severity, recency of onset, and satisfaction with treatment...
  22. pmc Corticotropin-releasing factor receptor 1 antagonist alters regional activation and effective connectivity in an emotional-arousal circuit during expectation of abdominal pain
    Catherine S Hubbard
    Center for the Neurobiology of Stress and Departments of Medicine, Physiology, and Psychiatry, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 31:12491-500. 2011
    ..activation and effective connectivity of a stress-related emotional-arousal circuit during expectation of abdominal pain using functional magnetic resonance imaging in human subjects with a diagnosis of IBS and healthy controls (..
  23. ncbi Recurrent abdominal pain, anxiety, and depression in primary care
    John V Campo
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Pediatrics 113:817-24. 2004
    The prevalence of psychiatric disorder in children and adolescents with functional recurrent abdominal pain (RAP) is unknown...
  24. doi Pancreatic neuropathy and neuropathic pain--a comprehensive pathomorphological study of 546 cases
    Güralp O Ceyhan
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Gastroenterology 136:177-186.e1. 2009
    ....
  25. ncbi Natural history of functional gastrointestinal disorders: a 12-year longitudinal population-based study
    Smita L S Halder
    Dyspepsia Center, Enteric Neuroscience Program, Division of Gastroenterology and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gastroenterology 133:799-807. 2007
    ..The natural history of FGID is unknown because of a lack of prospective population-based studies and the indistinct nature of the phenotype. We sought to report the natural history of FGID in a US population...
  26. pmc Development and psychometric testing of the Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS)
    Mariette Bengtsson
    Division of Gastroenterology and Hepatology, Department of Medicine, Malmo University Hospital, Sweden
    BMC Gastroenterol 7:16. 2007
    ..The Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS) questionnaire was designed to measure the treatment response of symptoms and well-being in patients suffering from IBS...
  27. ncbi Prevalence of irritable bowel syndrome according to different diagnostic criteria in a non-selected adult population
    M T Hillilä
    Department of Medicine, Division of Gastroenterology, Helsinki University Central Hospital, Helsinki, Finland
    Aliment Pharmacol Ther 20:339-45. 2004
    ..Prevalence of irritable bowel syndrome shows great variation among epidemiological studies, which may be due to different diagnostic criteria...
  28. ncbi Adult intussusception: a retrospective review
    Ahmad Zubaidi
    Department of Surgery, Saint Boniface Hospital, Winnipeg, Manitoba, Canada
    Dis Colon Rectum 49:1546-51. 2006
    ..The condition is usually secondary to a definable lesion. This study was designed to review adult intussusception, including presentation, diagnosis, and optimal treatment...
  29. ncbi Pain in chronic pancreatitis: the role of reorganization in the central nervous system
    Georg Dimcevski
    Center for Visceral Biomechanics and Pain, Department of Gastroenterology, Aalborg University Hospital, Aalborg, Denmark
    Gastroenterology 132:1546-56. 2007
    ..In various chronic pain conditions cortical reorganization seems to play a role in the manifestations. The aim of this study was to investigate cortical reorganization in patients with pain caused by chronic pancreatitis...
  30. ncbi Behaviour-based assessment of the duration of laparotomy-induced abdominal pain and the analgesic effects of carprofen and buprenorphine in rats
    J V Roughan
    Comparative Biology Centre, The Medical School, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK
    Behav Pharmacol 15:461-72. 2004
    ..The study demonstrates a clinically relevant and practically useful approach to assessing the duration of post-surgical abdominal pain and analgesic effects in rats.
  31. ncbi Estrogen-dependent abdominal hyperalgesia induced by ovariectomy in adult mice: a model of functional abdominal pain
    Raul Sanoja
    Anesthesia Research Unit Faculty of Medicine, Faculty of Dentistry and McGill Center for Pain Research, McGill University, Montreal, Quebec, Canada
    Pain 118:243-53. 2005
    Some abdominal pain syndromes are characterized by persistent pain without demonstrable pathology...
  32. pmc Predictors of patient-assessed illness severity in irritable bowel syndrome
    Brennan Spiegel
    VA Greater Los Angeles Healthcare System, Center for Outcomes Research and Education, Los Angeles, California, USA
    Am J Gastroenterol 103:2536-43. 2008
    ..Since severity is a patient-centered outcome, it is essential that future instruments are based on patients' self-perceptions of severity. We measured patient-derived predictors of severity in a large cohort of IBS patients...
  33. doi Children in pain: recurrent back pain, abdominal pain, and headache in children and adolescents in a four-year-period
    Hester van Gessel
    Georg Elias Müller Institute of Psychology, Department of Clinical Psychology and Psychotherapy, Georg August University of Gottingen, Gottingen, Germany
    J Pediatr 158:977-983.e1-2. 2011
    ..To analyze the development of recurrent pain in 3 body locations in children and adolescents (baseline age, 9 to 14 years) in a 4-year period...
  34. doi A million-dollar work-up for abdominal pain: is it worth it?
    Gati Dhroove
    Department of Pediatric Gastroenterology, Hepatology and Nutrition, Children s Memorial Hospital, Northwestern University, Chicago, IL 60614, USA
    J Pediatr Gastroenterol Nutr 51:579-83. 2010
    ..Despite limited evidence, investigations are commonly performed. The aim of the study was to investigate diagnostic practices, yield, and costs in children with PP-FGIDs...
  35. pmc Cognitive-behavioral therapy for children with functional abdominal pain and their parents decreases pain and other symptoms
    Rona L Levy
    School of Social Work, University of Washington, Seattle, Washington 98105, USA
    Am J Gastroenterol 105:946-56. 2010
    Unexplained abdominal pain in children has been shown to be related to parental responses to symptoms...
  36. doi Pregabalin reduces pain in patients with chronic pancreatitis in a randomized, controlled trial
    Søren Schou Olesen
    Mech Sense, Department of Gastroenterology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Gastroenterology 141:536-43. 2011
    ..We investigated whether agents used to treat patients with neuropathic pain are effective in CP...
  37. doi Abdominal pain-predominant functional gastrointestinal diseases in children and adolescents: prevalence, symptomatology, and association with emotional stress
    Niranga Manjuri Devanarayana
    Department of Physiology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka
    J Pediatr Gastroenterol Nutr 53:659-65. 2011
    ..We assessed the prevalence of abdominal pain-predominant FGD, in addition to the predisposing factors and symptomatology, in Sri Lankan children.
  38. pmc Neurokinin-1-receptor antagonism decreases anxiety and emotional arousal circuit response to noxious visceral distension in women with irritable bowel syndrome: a pilot study
    K Tillisch
    Center for Neurobiology of Stress, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Aliment Pharmacol Ther 35:360-7. 2012
    Irritable bowel syndrome is characterised by chronic abdominal pain and frequent comorbid anxiety...
  39. doi Long-term follow-up of gut-directed hypnotherapy vs. standard care in children with functional abdominal pain or irritable bowel syndrome
    Arine M Vlieger
    Department of Pediatrics, St Antonius Hospital, Nieuwegein, The Netherlands
    Am J Gastroenterol 107:627-31. 2012
    ..showed that gut-directed hypnotherapy (HT) is highly effective in the treatment of children with functional abdominal pain (FAP) and irritable bowel syndrome (IBS)...
  40. pmc Factors related to abdominal pain in gastroparesis: contrast to patients with predominant nausea and vomiting
    W L Hasler
    University of Michigan, Ann Arbor, Michigan, USA
    Neurogastroenterol Motil 25:427-38, e300-1. 2013
    Factors associated with abdominal pain in gastroparesis are incompletely evaluated and comparisons of pain vs other symptoms are limited...
  41. pmc Sex-related differences of cortical thickness in patients with chronic abdominal pain
    Zhiguo Jiang
    Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress and Pain and Interoception Network PAIN Repository, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America Human Performance and Engineering Laboratory, Kessler Foundation Research Center, West Orange, New Jersey, United States of America Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey, United States of America
    PLoS ONE 8:e73932. 2013
    ..We aimed to characterize regional changes in cortical thickness (CT) in a large number of well phenotyped IBS patients, taking into account the role of sex related differences...
  42. doi Altered brain microstructure assessed by diffusion tensor imaging in patients with chronic pancreatitis
    Jens Brøndum Frøkjær
    Department of Radiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    Gut 60:1554-62. 2011
    ..Using magnetic resonance (MR) diffusion tensor imaging, brain microstructure in areas involved in processing of visceral pain was characterised and these findings were correlated to clinical pain scores...
  43. doi Clinical and laboratory findings in 220 children with recurrent abdominal pain
    C F M Gijsbers
    Department of Paediatric Gastroenterology, Juliana Children s Hospital Haga Teaching Hospital, The Hague, The Netherlands
    Acta Paediatr 100:1028-32. 2011
    To investigate the clinical and laboratory findings in children with recurrent abdominal pain (RAP).
  44. ncbi Rectus sheath hematoma: review of 126 cases at a single institution
    W Brett Cherry
    Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Medicine (Baltimore) 85:105-10. 2006
    Rectus sheath hematoma (RSH) is an uncommon condition characterized by abdominal pain and an abdominal wall mass...
  45. doi Diagnostic work-up of inflammatory bowel disease in children: the role of calprotectin assay
    A Diamanti
    Gastroenterology and Nutrition Unit, Bambino Gesu Children s Hospital, Rome, Italy
    Inflamm Bowel Dis 16:1926-30. 2010
    ..of the fecal calprotectin assay, compared to histology, as a stool-screening biomarker for inflammatory bowel disease (IBD) among a group of prospectively identified patients referred for recurrent abdominal pain and altered bowel habits.
  46. pmc Multicenter, randomized, placebo-controlled trial of amitriptyline in children with functional gastrointestinal disorders
    Miguel Saps
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children s Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
    Gastroenterology 137:1261-9. 2009
    ..The aim of this study was to evaluate the efficacy of amitriptyline in children with pain-predominant functional gastrointestinal disorders...
  47. ncbi Systematic review of the role of thoracoscopic splanchnicectomy in palliating the pain of patients with chronic pancreatitis
    Saleh Baghdadi
    Department of Surgery, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK
    Surg Endosc 22:580-8. 2008
    The management of opiate-dependent intractable abdominal pain caused by chronic pancreatitis remains challenging. The published series on the role, safety, feasibility, and efficacy of thoracoscopic splanchnicectomy are reviewed.
  48. ncbi Laparoscopic adhesiolysis in patients with chronic abdominal pain: a blinded randomised controlled multi-centre trial
    D J Swank
    Department of Surgery, Groene Hart Hospital, Gouda, Netherlands
    Lancet 361:1247-51. 2003
    Laparoscopic adhesiolysis for chronic abdominal pain is controversial and is not evidence based...
  49. ncbi Angiolipoma of the colon with right lower quadrant abdominal pain
    K Kato
    2nd Department of Surgery, Asahikawa Medical College, Asahikawa, Japan
    Dig Surg 16:441-4. 1999
    ..An angiolipoma is a common benign neoplasm with a characteristic vascular component that occurs in the subcutaneous tissue and rarely in the gastrointestinal tract. We report on a 69-year-old man with a submucosal angiolipoma in the cecum...
  50. doi Extracorporeal shock wave lithotripsy for prevention of recurrent pancreatitis caused by obstructive pancreatic stones
    Mansour A Parsi
    Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA
    Pancreas 39:153-5. 2010
    Obstructive pancreatic duct stones can cause recurrent attacks of acute pancreatitis and chronic abdominal pain. Use of extracorporeal shock wave lithotripsy (ESWL) for treatment of abdominal pain associated with obstructive pancreatic ..
  51. ncbi Recurrent abdominal pain in children
    Niranga Manjuri Devanarayana
    Department of Physiology, Faculty of Medicine, University of Kelaniya, Sri Lanka
    Indian Pediatr 46:389-99. 2009
    Recurrent abdominal pain is one of the commonest gastrointestinal complaints in children, affecting approximately 10% of school aged children and adolescents...
  52. doi Abdominal pain in the ED: a 35 year retrospective
    Ramin S Hastings
    Department of Medicine, School of Medicine, University of Virginia Health System, Charlottesville, VA, USA
    Am J Emerg Med 29:711-6. 2011
    ..the demographics, diagnoses, and diagnostic test utilization of adult patients presenting with nontraumatic abdominal pain to the emergency department (ED) at the University of Virginia Hospital...
  53. pmc Rome II versus Rome III classification of functional gastrointestinal disorders in pediatric chronic abdominal pain
    Kari F Baber
    Department of Pediatrics, Division of Adolescent Medicine and Behavioral Science, Vanderbilt University Medical Center, Nashville, TN, USA
    J Pediatr Gastroenterol Nutr 47:299-302. 2008
    ..The purpose of this study was to compare classification results using Rome II versus Rome III criteria for FGIDs associated with chronic abdominal pain.
  54. pmc Non-specific abdominal pain and air pollution: a novel association
    Gilaad G Kaplan
    Division of Gastroenterology, University of Calgary, Calgary, Alberta, Canada
    PLoS ONE 7:e47669. 2012
    We studied whether short-term exposure to air pollution was associated with non-specific abdominal pain in epidemiologic and animal studies.
  55. doi Prevalence of functional gastrointestinal diseases in a cohort of Sri Lankan adolescents: comparison between Rome II and Rome III criteria
    Niranga Manjuri Devanarayana
    Department of Physiology, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka
    J Trop Pediatr 57:34-9. 2011
    ..8%) had abdominal-pain-related FGDs [irritable bowel syndrome (IBS) 30, functional dyspepsia 15, functional abdominal pain 13 and abdominal migraine 1]...
  56. doi Technical aspects of spinal cord stimulation for managing chronic visceral abdominal pain: the results from the national survey
    Leonardo Kapural
    Department of Pain Management, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Pain Med 11:685-91. 2010
    ..AND METHODS: A few recent reports suggested that spinal cord stimulation (SCS) effectively suppresses chronic abdominal pain. However, there is no consensus on patient selection or technical aspects of SCS for such pain...
  57. ncbi G-protein beta 3 subunit 825 CC genotype is associated with unexplained (functional) dyspepsia
    Gerald Holtmann
    Gastroenterology and Hepatology, University of Essen, Germany
    Gastroenterology 126:971-9. 2004
    ..We aimed to assess the association of specific G-protein beta 3 subunit genotypes with functional dyspepsia...
  58. ncbi Health-related quality of life and health care costs in severe, refractory irritable bowel syndrome
    F Creed
    School of Psychiatry and Behavioural Science, Rawnsley Building, Oxford Road, Manchester M13 9WL, United Kingdom
    Ann Intern Med 134:860-8. 2001
    ..MEASUREMENTS: Predictors were abdominal pain, entries in a diary of 10 IBS symptoms, and measures of psychological symptoms...
  59. doi Type II enteropathy-associated T-cell lymphoma: a multicenter analysis from the Asia Lymphoma Study Group
    Eric Tse
    Department of Medicine, Queen Mary Hospital, Hong Kong, China
    Am J Hematol 87:663-8. 2012
    ..Age and the prognostic index for peripheral T-cell lymphoma were not prognostically significant. Good performance status was associated with better OS (P = 0.03), and response to initial treatment led to better OS and PFS (P < 0.001)...
  60. doi Recurrent abdominal pain syndrome in a cohort of Sri Lankan children and adolescents
    Niranga Manjuri Devanarayana
    Department of Physiology, Faculty of Medicine, University of Kelaniya Thalagolla road, Ragama, Sri Lanka
    J Trop Pediatr 54:178-83. 2008
    Recurrent abdominal pain (RAP) is a common problem among children and adolescents. The epidemiology of RAP among Sri Lankan children is unknown...
  61. doi Pancreatic pain
    Güralp O Ceyhan
    Department of Surgery, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, D 81675 Munich, Germany
    Best Pract Res Clin Gastroenterol 22:31-44. 2008
    b>Abdominal pain is an important clinical symptom in pancreatic diseases. There is increasing evidence that pain in chronic pancreatitis and pancreatic cancer is triggered by pancreatic neuropathy...
  62. ncbi Internal hernia as a complication of laparoscopic Roux-en-Y gastric bypass
    Antonio Iannelli
    Universite de Nice Sophia Antipolis, Faculte de Medecine, Nice, F 06107, France
    Obes Surg 17:1283-6. 2007
    ..Internal hernia (IH) is a well known complication of Roux-en-Y gastric bypass (RYGBP) which is more frequently encountered when the RYGBP is done laparoscopically...
  63. doi Diagnostic yield and therapeutic impact of single-balloon enteroscopy: series of 106 cases
    Mohan Ramchandani
    Asian Institute of Gastroenterology, Hyderabad, India
    J Gastroenterol Hepatol 24:1631-8. 2009
    ..This prospective study was done in a tertiary care center to evaluate the feasibility, complications, diagnostic and therapeutic yield of SBE in patients with suspected small bowel disorders...
  64. ncbi Abdominal pain accompanied by weight loss may increase the diagnostic yield of capsule endoscopy: a Korean multicenter study
    Ki Nam Shim
    Ewha Womans University College of Medicine, and Yang Hospital, Seoul, Korea
    Scand J Gastroenterol 41:983-8. 2006
    ..The aim of the present study was to determine in which subgroup of patients with unexplained abdominal pain, CE would be a helpful evaluation tool.
  65. pmc Pain in chronic pancreatitis: a salutogenic mechanism or a maladaptive brain response?
    Felipe Fregni
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Pancreatology 7:411-22. 2007
    ..Furthermore, we consider these aspects in light of a new approach to treat visceral pain: transcranial magnetic stimulation, a noninvasive method of brain stimulation...
  66. doi Efficacy of endoscopic ultrasound-guided celiac plexus block and celiac plexus neurolysis for managing abdominal pain associated with chronic pancreatitis and pancreatic cancer
    Marina Kaufman
    Division of Gastroenterology and Hepatology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    J Clin Gastroenterol 44:127-34. 2010
    ..Given limited data, their use remains controversial. Herein, we evaluate the efficacy of EUS-guided CPB and CPN in alleviating chronic abdominal pain due to chronic pancreatitis and pancreatic cancer respectively.
  67. pmc A self administered reliable questionnaire to assess lower bowel symptoms
    Barbara Ann Adelstein
    Screening and Test Evaluation Program STEP, School of Public Health, University of Sydney, Australia
    BMC Gastroenterol 8:8. 2008
    ..Our aim was to develop a self administered questionnaire for eliciting the presence, nature and severity of lower bowel symptoms potentially related to colorectal cancer, and assess its reliability...
  68. pmc The brain-gut axis in abdominal pain syndromes
    Emeran A Mayer
    Center for Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Annu Rev Med 62:381-96. 2011
    ..In patients with functional abdominal pain syndromes, conscious perception of interoceptive information from the GI tract, or recall of interoceptive ..
  69. ncbi A randomized controlled trial of a cognitive-behavioral family intervention for pediatric recurrent abdominal pain
    Paul M Robins
    The Children s Hospital of Philadelphia, Department of Psychology, 3405 Civic Center Blvd, CSH 15, Philadelphia, PA 19104, USA
    J Pediatr Psychol 30:397-408. 2005
    To investigate whether the combination of standard medical care (SMC) and short-term cognitive-behavioral family treatment (CBT) in the treatment of recurrent abdominal pain (RAP) was more effective than SMC alone.
  70. ncbi Novel single-balloon enteroscopy for diagnosis and treatment of the small intestine: preliminary experiences
    T Tsujikawa
    Division of Gastroenterology, Shiga University of Medical Science Hospital, Shiga, Japan
    Endoscopy 40:11-5. 2008
    ..The aim of the present study was to evaluate the insertion technique, the safety, and the clinical impact of the SBE system...
  71. doi Functional gastrointestinal disorders as a public health problem
    N J Talley
    Department of Internal Medicine, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Neurogastroenterol Motil 20:121-9. 2008
    ....
  72. pmc Risk of ovarian cancer in women with symptoms in primary care: population based case-control study
    William Hamilton
    NIHR School for Primary Care Research, Department of Community Based Medicine, University of Bristol, Bristol BS8 2AA, UK
    BMJ 339:b2998. 2009
    ..To identify and quantify symptoms of ovarian cancer in women in primary care...
  73. ncbi Headache and recurrent abdominal pain: a controlled study by the means of the Child Behaviour Checklist (CBCL)
    F Galli
    Faculty of Psychology 1, Univesity of Rome La Sapienza, Rome, Italy
    Cephalalgia 27:211-9. 2007
    Headache and recurrent abdominal pain (RAP) are common disorders in children and adolescents, frequently referred to paediatricians...
  74. ncbi Recurrent pain symptoms in young schoolchildren are often multiple
    Solveig Petersen
    Department of Clinical Sciences, Paediatrics, Umea University, Umea, Sweden
    Pain 121:145-50. 2006
    ..Furthermore, the high prevalence of multiple symptoms indicates that recurrent pain symptoms in children, particularly frequent symptoms, should be regarded a potential general pain disorder rather than merely a localized body disorder...
  75. ncbi Stability of irritable bowel syndrome using a Rome II-based classification
    R E Williams
    Worldwide Epidemiology, Glaxo SmithKline, Research Triangle Park, NC 27709, USA
    Aliment Pharmacol Ther 23:197-205. 2006
    ..As there is no biological marker for irritable bowel syndrome, a diagnosis is made using symptom-based criteria...
  76. ncbi Systematic review of treatments for recurrent abdominal pain
    Joy A Weydert
    Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona 85724 5073, USA
    Pediatrics 111:e1-11. 2003
    To conduct a systematic review of evaluated treatments for recurrent abdominal pain (RAP) in children.
  77. pmc Increased gastrointestinal permeability and gut inflammation in children with functional abdominal pain and irritable bowel syndrome
    Robert J Shulman
    Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    J Pediatr 153:646-50. 2008
    ..GI) permeability and fecal calprotectin concentration in children 7 to 10 years of age with functional abdominal pain and irritable bowel syndrome (FAP/IBS) versus control subjects and ascertain potential relationships with pain ..
  78. pmc E148Q is a disease-causing MEFV mutation: a phenotypic evaluation in patients with familial Mediterranean fever
    R Topaloglu
    Hacettepe University Faculty of Medicine, Department of Paediatric Nephrology and Rheumatology, 06100 Ankara, Turkey
    Ann Rheum Dis 64:750-2. 2005
    ..Several mutations in the MEFV gene, including E148Q, have been identified as causing this disease. It has been suggested that the E148Q mutation is the mildest mutation and some reports have questioned its disease association...
  79. doi Update on irritable bowel syndrome and gender differences
    Margaret M Heitkemper
    Department of Biobehavioral Nursing, University of Washington, Seattle, WA 98195, USA
    Nutr Clin Pract 23:275-83. 2008
    Irritable bowel syndrome (IBS) is a chronic functional GI disorder characterized by abdominal pain associated with alterations in defecation or stool frequency and consistency...
  80. ncbi Diagnostic yield of colonoscopy based on symptoms
    Anders Lasson
    Department of Internal Medicine, Boras Hospital, Boras, Sweden
    Scand J Gastroenterol 43:356-62. 2008
    ..The aim of this study was to assess the outcome of colonoscopy in patients with various gastrointestinal symptoms and to estimate the relation between the findings and the presenting symptoms...
  81. ncbi Repetitive rectal painful distention induces rectal hypersensitivity in patients with irritable bowel syndrome
    Tsukasa Nozu
    Department of Comprehensive Medicine, Hokkaido University Hospital, Kita 14, Nishi 5, Sapporo, 060 8648, Japan
    J Gastroenterol 41:217-22. 2006
    ..baseline and after conditioning (repetitive rectal painful distention: RRD) in patients with IBS or functional abdominal pain syndrome (FAPS), which is an abdominal pain disorder, and in healthy controls, and determined whether rectal ..
  82. ncbi Parent reports of coping and stress responses in children with recurrent abdominal pain
    Alexandra Harding Thomsen
    University of Vermont, Burlington 05405, USA
    J Pediatr Psychol 27:215-26. 2002
    To examine relationships among coping, stress responses, pain, somatic symptoms, and anxious/depressed symptoms in a sample of children and adolescents with recurrent abdominal pain (RAP).
  83. ncbi Recurrent abdominal pain: a five-year follow-up study
    Ketil Størdal
    Department of Paediatrics, Sykehuset Ostfold Fredrikstad, Fredrikstad, Norway
    Acta Paediatr 94:234-6. 2005
    To explore the long-term prognosis for children referred for recurrent abdominal pain (RAP), 44 children investigated for RAP 5 y ago were compared to a group of controls (n=88)...
  84. doi Pain in chronic pancreatitis: the role of neuropathic pain mechanisms
    A M Drewes
    Mech Sense, Department of Gastroenterology, Aalborg University Hospital, DK 9000 Aalborg, Denmark
    Gut 57:1616-27. 2008
    ..In conclusion, a mechanism-based understanding of pain in chronic pancreatitis may have important implications for the treatment...
  85. doi Aetiology of recurrent abdominal pain in a cohort of Sri Lankan children
    Niranga M Devanarayana
    Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka
    J Paediatr Child Health 44:195-200. 2008
    Recurrent abdominal pain (RAP) has a multifactorial aetiology with many affected children having no evidence of organic pathology. This study assessed the functional and organic causes for RAP in a cohort of Sri Lankan children.
  86. pmc Parent attention versus distraction: impact on symptom complaints by children with and without chronic functional abdominal pain
    Lynn S Walker
    Vanderbilt University Medical Center, Division of Adolescent Medicine and Behavioral Science, Vanderbilt Children s Hospital, Nashville, TN 37232 9060, USA
    Pain 122:43-52. 2006
    ..of parent attention and distraction on symptom complaints by children with and without chronic functional abdominal pain. The water load symptom provocation task was used to induce visceral discomfort in pediatric patients with ..
  87. pmc Adult intussusception: case reports and review of literature
    S Yalamarthi
    Department of General Surgery, Falkirk District and Royal Infirmary, Falkirk, Scotland
    Postgrad Med J 81:174-7. 2005
    ..With more frequent use of computed tomography in the evaluation of patients with abdominal pain, the condition can be diagnosed more reliably. Treatment entails simple bowel resection in most cases...
  88. pmc Treatment for painful calcified chronic pancreatitis: extracorporeal shock wave lithotripsy versus endoscopic treatment: a randomised controlled trial
    Jean Marc Dumonceau
    Department of Gastroenterology, Erasmus University Hospital, Brussels, Belgium
    Gut 56:545-52. 2007
    ..Pilot studies suggest that extracorporeal shock wave lithotripsy (ESWL) alone relieves pain in calcified chronic pancreatitis...
  89. ncbi Abdominal pain and bowel dysfunction: diagnostic role of intestinal ultrasound
    M Astegiano
    U.O.A. Gastroenterologia, Azienda Ospedaliera San Giovanni Battista di Torino, Italy
    Eur J Gastroenterol Hepatol 13:927-31. 2001
    BACKGROUND: Abdominal pain and irregular bowel habits are common among young people. Irritable bowel syndrome is frequent in the general population and has important economic and social costs...
  90. ncbi Endoscopic ultrasound-guided celiac plexus block for managing abdominal pain associated with chronic pancreatitis: a prospective single center experience
    F Gress
    Division of Gastroenterology and Hepatology, Indiana University Medical Center, Indianapolis, USA
    Am J Gastroenterol 96:409-16. 2001
    ..we suggested a possible role for endoscopic ultrasound (EUS) guided celiac plexus block in the treatment of abdominal pain associated with chronic pancreatitis...
  91. ncbi Psychological comorbidity and stress reactivity in children and adolescents with recurrent abdominal pain and anxiety disorders
    Lorah D Dorn
    University of Pittsburgh, PA 15261, USA
    J Am Acad Child Adolesc Psychiatry 42:66-75. 2003
    To compare clinical symptoms, diagnoses, and physiological measures in children and adolescents with recurrent abdominal pain (RAP) (n = 14), to a group with anxiety disorders (ANX) (n = 14) and a physically and psychiatrically healthy ..
  92. pmc Omental actinomycosis presenting with right lower quadrant abdominal pain
    J Abela
    J Clin Pathol 57:671. 2004
  93. ncbi Functional abdominal pain syndrome
    Douglas A Drossman
    UNC Center for Functional GI and Motility Disorders, University of North Carolina School of Medicine at Chapel Hill, USA
    Clin Gastroenterol Hepatol 2:353-65. 2004
    Functional abdominal pain syndrome (FAPS) is one of the less common functional gastrointestinal disorders, yet it is one with high health care impact...
  94. ncbi Development of an ovarian cancer symptom index: possibilities for earlier detection
    Barbara A Goff
    Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington 98196 6460, USA
    Cancer 109:221-7. 2007
    ..Currently, screening for ovarian cancer is not recommended for the general population. Targeting women with specific symptoms for screening has been evaluated only recently, because it was believed that symptoms had limited specificity...
  95. ncbi Helicobacter pylori infection in Iranian children with recurrent abdominal pain
    Nahid Masoodpoor
    Department of Paediatrics, Rafsanjan, University of Medical Sciences, Rafsanjan, Iran
    Trop Gastroenterol 29:221-3. 2008
    Helicobacter pylori infection may be a cause of recurrent abdominal pain (RAP) in children. However, this relationship between H. pylori infection and RAP has not yet been confirmed.
  96. ncbi A randomized double-blind placebo-controlled trial of Lactobacillus GG for abdominal pain disorders in children
    A Gawronska
    Department of Paediatric Gastroenterology and Nutrition, The Medical University of Warsaw, Warsaw, Poland
    Aliment Pharmacol Ther 25:177-84. 2007
    Functional abdominal pain disorders (FAPD) are common in school-aged children; however, there is no reliable treatment.
  97. pmc Recurrent abdominal pain and weight loss in an adolescent: celiac artery compression syndrome
    Sarah Gander
    Department of Pediatrics, Queen s University, Kingston, Ontario, Canada
    Can J Gastroenterol 24:91-3. 2010
    Celiac artery compression syndrome is a rare cause of abdominal pain and weight loss, likely caused by compression of the celiac artery or plexus by the median arcuate ligament...
  98. ncbi Pediatric appendicitis score
    Madan Samuel
    Department of Pediatric Urology, Great Ormond Street Hospital for Children NHS Trust, London, England
    J Pediatr Surg 37:877-81. 2002
    ..Morbidity in children treated with appendicitis results either from late diagnosis or negative appendectomy. A Prospective analysis of efficacy of Pediatric Appendicitis Score for early diagnosis of appendicitis in children was conducted...
  99. doi Diagnosing pediatric functional abdominal pain in children (4-15 years old) according to the Rome III Criteria: results from a Norwegian prospective study
    Helene Helgeland
    Department of Child and Adolescent Psychiatry, Innlandet Hospital Trust, Gjøvik, Norway
    J Pediatr Gastroenterol Nutr 49:309-15. 2009
    To determine the proportion of referred children with nonorganic abdominal pain who meet the criteria for 1 or more diagnoses of functional gastrointestinal disorders (FGID), explore the distribution of diagnoses according to the revised ..
  100. doi Abdominal pain in Irritable Bowel Syndrome: a review of putative psychological, neural and neuro-immune mechanisms
    Sigrid Elsenbruch
    Inst of Medical Psychology and Behavioral Immunobiology, University Clinic of Essen, University of Duisburg Essen, Germany
    Brain Behav Immun 25:386-94. 2011
    Chronic abdominal pain is a common symptom of great clinical significance in several areas of medicine. In many cases no organic cause can be established resulting in the classification as functional gastrointestinal disorder...
  101. ncbi The AIDS patient with abdominal pain: a new challenge for the emergency physician
    Ellen M Slaven
    Division of Emergency Medicine, Department of Medicine, Charity Hospital, Louisiana State University, 1542 Tulane Avenue, New Orleans, LA 70112, USA
    Emerg Med Clin North Am 21:987-1015. 2003
    ..continues to increase, EPs will be called upon to evaluate increasing numbers of AIDS patients who have abdominal pain, some of whom will require emergent surgical intervention...

Research Grants78

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Chronic Stress and Abdominal Pain: Novel Mechanisms
    John W Wiley; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic Stress and Abdominal Pain: Novel Mechanisms Chronic stress activates the Hypothalamic-Pituitary-Adrenal (HPA) axis and is a known inducer of abdominal pain...
  3. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
    Acute pancreatitis is an inflammatory condition with 5-10% mortality rate. Severe abdominal pain is the most prominent symptom, however the mechanisms of pancreatic inflammatory pain are poorly understood and consequently the therapeutic ..
  4. Understanding Pain of Gastrointestinal Origin in Women that Serve in OEF/OIF
    Beverley Greenwood-Van Meerveld; Fiscal Year: 2013
    ..limited data is available for female veterans that serve in OEF/OIF, studies have shown that symptoms of abdominal pain are due to visceral hypersensitivity characterized by increased awareness of visceral stimuli in Gulf War ..
  5. New drug VS-110 for treating inflammatory bowel diseases
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2013
    ..Symptoms may include abdominal pain, severe diarrhea and malnutrition...
  6. Functional Bowel Disorders in Chinese Medicine
    Brian Berman; Fiscal Year: 2009
    Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that is characterized by recurrent abdominal pain and disturbance in bowel movements...
  7. Modulation of Colonic Epithelial Permeability by Sex Hormones
    Muriel Larauche; Fiscal Year: 2013
    ..possibility of sex differences in the alterations of colonic mucosal neuroimmune functions in relation with abdominal pain and constipation symptoms in IBS patients has not been investigated...
  8. Central Mechanisms Modulating Visceral Sensitivity
    Beverley Greenwood-Van Meerveld; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Chronic gastrointestinal (GI) symptoms, such as severe abdominal pain and diarrhea are among the most frequently reported symptoms in Veterans returning from active duty...
  9. TAM receptor tyrosine kinases in inflammatory bowel disease
    Carla Rothlin; Fiscal Year: 2013
    ..chronic, relapsing inflammatory disorders of the gastrointestinal tract characterized by diarrhea, bleeding, abdominal pain, and weight loss...
  10. Stress and Visceral Hyperalgesia: Epigenetic Mechanisms
    John W Wiley; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Chronic stress is a well-known trigger for abdominal pain, a common yet poorly understood presentation in the clinical setting...
  11. Mechanisms of Postoperative Ileus
    YVETTE FRANCE TACHE; Fiscal Year: 2012
    ..Besides causing significant discomfort to patients (bloating, nausea, emesis, and abdominal pain), POI hampers recovery and constitutes the most common reason for delaying discharge from the hospital after ..
  12. FUNCTION OF THE ENTERIC NERVOUS SYSTEM
    JACKIE WOOD; Fiscal Year: 2013
    ..interactions is basic for understanding visceral hypersensitivity and emerging recognition that functional abdominal pain involves co-morbidity of intestinal hypersensitivity with other pain syndromes (e.g...
  13. Role of STAT3 in the pathogenesis of Inflammatory Bowel Disease
    Prema Robinson; Fiscal Year: 2013
    ..An estimated 1.4 million persons in the United States suffer from IBD. IBD causes severe diarrhea, abdominal pain and increases the risk of colorectal cancer. Importantly, there is no cure for IBD...
  14. Sex Hormones and Visceral Hypersensitivity
    Elie D Al-Chaer; Fiscal Year: 2012
    ..In addition, we have shown that persistent abdominal pain without inflammation can be modeled in animals...
  15. Nitrergic Neuro-smooth Muscle Transmission in the Gut
    Raj K Goyal; Fiscal Year: 2013
    ..in a variety of diseases that cause difficulty in swallowing, heartburn, dyspepsia, constipation and chronic abdominal pain. This proposal is to understand how these disorders are caused and how better treatments for these disorders ..
  16. Mechanisms underlying TMD-IBS comorbidity
    Richard J Traub; Fiscal Year: 2013
    ..As many as 60% of patients with temporomandibular disorder (TMD) also report symptoms of abdominal pain consistent with irritable bowel syndrome (IBS), but the underlying connection between these comorbid ..
  17. Non-invasive Ultrasound Elasticity Imaging (UEI) in Crohn's Disease
    Jonathan M Rubin; Fiscal Year: 2010
    ..This has a substantial impact on quality of life and medical costs. When Crohn's patients have abdominal pain and vomiting, this indicates severe narrowing of the small intestine...
  18. STRESS-INDUCED ACTIVATION OF COLONIC MOTOR FUNCTION
    YVETTE FRANCE TACHE; Fiscal Year: 2013
    ..provided by applicant): Abstract Irritable bowel syndrome (IBS) is a stress-sensitive disorder for which abdominal pain is a cardinal symptom that drives illness severity more than other motor symptoms...
  19. Mechanisms of host-bacterial interactions, ileitis and granuloma formation in Agr
    Steven M Lipkin; Fiscal Year: 2013
    ..is characterized by chronic, relapsing intestinal inflammation producing debilitating symptoms of diarrhea, abdominal pain and malnutrition. Its main forms are Crohn's disease and ulcerative colitis...
  20. Novel Breath Test To Detect Early Stage Chronic Pancreatitis
    DAVID A contact WAGNER; Fiscal Year: 2010
    ..Advanced CP causes severe structural damage to the pancreas leading to chronic abdominal pain, endocrine failure (diabetes mellitus) and exocrine failure (fat malabsorption)...
  21. Patient research in eosinophilic gastrointestinal diseases
    Glenn T Furuta; Fiscal Year: 2013
    ..an increasingly recognized group of diseases affecting children and adults characterized by nausea, vomiting, abdominal pain, dysphagia, food impaction and diarrhea that occur in conjunction with intestinal eosinophilia...
  22. Exploring statins as a small molecule therapy for treatment of schistosomiasis
    Conor Caffrey; Fiscal Year: 2013
    ..Ensuing anemia, abdominal pain, impaired physical and cognitive development degrade individual and societal productivity...
  23. Protocol- vs Patient-Oriented TCM Practices: A RCT for IBS Symptom Management
    Joyce K Anastasi; Fiscal Year: 2012
    ..IBS has been defined as abdominal pain/discomfort in the mid or lower gastrointestinal (Gl) tract, associated with defecation or a change in bowel ..
  24. Mechanisms of Altered Gastrointestinal Dysfunction
    QiQi Zhou; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Patients with irritable bowel syndrome (IBS) suffer from chronic abdominal pain and associated GI symptoms - diarrhea, constipation, bloating &urgency...
  25. MICROENVIRONMENT IN ENTERIC NEURON DEVELOPMENT
    Michael D Gershon; Fiscal Year: 2013
    ..separation, as well as reports in humans with functional GI disorders of a history of infection, memories of abdominal pain during childhood, or a history of stress and/or abuse...
  26. Central Molecular Mechanisms of Stress-Induced Visceral Hypersensitivity
    ANTHONY CHRISTOPHER JOHNSON; Fiscal Year: 2012
    ..symptom of irritable bowel syndrome (IBS), a chronic functional gastrointestinal (GI) disorder, is severe abdominal pain, associated with altered bowel habits, in the absence of any identifiable disease...
  27. Symptom management for irritable bowel syndrome constipation (IBS-C)
    Joyce K Anastasi; Fiscal Year: 2013
    ..IBS is defined as abdominal pain/discomfort in the mid or lower gastrointestinal (GI) tract, associated with defecation or a change in bowel ..
  28. A NURSING STUDY OF GUT FUNCTION IN MENSTRUATING WOMEN
    Margaret McLean Heitkemper; Fiscal Year: 2013
    ..Irritable Bowel Syndrome (IBS) is a common functional gastrointestinal (GI) disorder characterized by abdominal pain and alterations in bowel pattern. IBS disproportionately affects women;10-15% of women are affected...
  29. Developmental Origins of Functional Dyspepsia
    Sushil K Sarna; Fiscal Year: 2013
    ..S. population. The two primary symptoms of Functional Dyspepsia are upper abdominal pain that is exaggerated by ingestion of a meal, and delayed gastric emptying...
  30. Scanning Chlamydia proteome for vaccine antigens
    Luis M de la Maza; Fiscal Year: 2010
    ..therapy is implemented in a timely manner, long-term sequelae including, pelvic inflammatory disease, chronic abdominal pain, ectopic pregnancy and infertility, may develop. In addition, a majority of the genital C...
  31. Novel Treatment Strategies for Constipation and Role of Brain-Gut axis
    SATISH SC RAO; Fiscal Year: 2011
    ..4) Constipation accompanied by abdominal pain is commonly associated with rectal hypersensitivity, a condition with no effective therapy...
  32. GSK3-beta Signaling in Medullary Thyroid Cancer
    Herbert Chen; Fiscal Year: 2013
    ..to treat many of the debilitating symptoms associated with incurable MTC such as airway obstruction, flushing, abdominal pain and diarrhea...
  33. Neuronal Changes in Adult Rats Induced by Neonatal Pain
    Adrian Miranda; Fiscal Year: 2011
    Functional abdominal pain affects about 17% of high school students and accounts for 2-4% of all pediatric office visits. The factors that lead to symptoms are not well understood...
  34. Alteration of lipid A acyl chain length in Salmonella
    Qingke Kong; Fiscal Year: 2013
    ..when administered to humans they can be reactogenic, producing unwanted side effects, including diarrhea, abdominal pain, gastrointestinal disorder, nervous system disorders, and fever...
  35. Detection and Diagnosis of Pancreatic Cancer
    David Gold; Fiscal Year: 2009
    ..The most common symptoms of the disease, jaundice, abdominal pain, and weight loss, together with other presenting factors are nonspecific in nature...
  36. GI Barrier and Microbiome Response to VSL3 in Irritable Bowel Syndrome
    Robert Shulman; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Ten to 46% of children 4 - 16 yr. of age around the world have recurrent abdominal pain and up to 66% of these develop irritable bowel syndrome (IBS) as adults...
  37. Predicting Response to Standardized Pediatric Colitis Therapy: The PROTECT Study
    Mi Ok Kim; Fiscal Year: 2011
    ..UC causes considerable suffering with abdominal pain, diarrhea, bleeding, and weight loss and for unknown reasons is often more severe in children than adults...
  38. The Human Microbiome in Pediatric Abdominal Pain and Intestinal Inflammation
    James Versalovic; Fiscal Year: 2012
    ..Ultimately, the discoveries from this project may allow physicians to manipulate microbes in the intestine in order to promote health and cure or prevent disease. ..
  39. Pathways to New Biomarkers in Recurrent Abdominal Pain in Children
    Robert Shulman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The phrase abdominal pain-related functional gastrointestinal (GI) disorders (APFGIDs) has replaced the term recurrent abdominal pain to describe a condition affecting 10%-46% of school age children ..
  40. Proteomics of Pancreatic Fluid and Urine in Chronic Pancreatitis
    Joao A Paulo; Fiscal Year: 2012
    ..In addition, the evaluation of chronic abdominal pain under the suspicion of CP results in millions of dollars in healthcare costs and lost wages annually...
  41. Randomized placebo-controlled trial of glutamine for patients with IBS
    G Nicholas Verne; Fiscal Year: 2012
    ..IBS patients suffer from chronic abdominal pain associated with diarrhea, constipation, and/or bloating (Verne &Cerda, 1997)...
  42. Phase 2 Study of Esophageal String Test in Diagnosing Eosinophilic Esophagitis
    Glenn T Furuta; Fiscal Year: 2013
    ..recognized rare disease of children and adults characterized by symptoms including nausea, vomiting, abdominal pain, dysphagia and food impaction that occur in conjunction with esophageal eosinophilia...
  43. Feelings/Body Investigators:Interoceptive Exposure for Children w/Abdominal Pain
    Nancy L Zucker; Fiscal Year: 2013
    ..by applicant): This application, Feelings and Body Investigators (FBI): Interoceptive Exposure for Child Abdominal Pain is in response to PA-11-177, Translational Research for the Development of Novel Interventions for Mental ..
  44. Sensitive and Specific Rapid Diagnostic Test for Acute and Chronic Pancreatitis
    SYAMAL X RAYCHAUDHURI; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The very common patient complaint of abdominal pain suggests the diagnosis of pancreatitis...
  45. An internet CBT intervention for pediatric chronic pain and disability
    Tonya M Palermo; Fiscal Year: 2013
    ..to 30% of otherwise healthy children and adolescents suffer from recurrent or chronic pain such as headache, abdominal pain, and musculoskeletal pain...
  46. Advancing Science for the Diagnosis and Treatment of Gastroparesis
    Pankaj J Pasricha; Fiscal Year: 2013
    ..emptying, frequently associated with chronic nausea and vomiting, early satiety, postprandial fullness, abdominal pain, and malnutrition that may require nutritional support...
  47. Continuation of the NIDDK Gastroparesis Consortium
    Irene Sarosiek; Fiscal Year: 2013
    ..emptying, frequently associated with chronic nausea and vomiting, early satiety, postprandial fullness, abdominal pain, and malnutrition that may require nutritional support...
  48. Perception and Modulation of Visceral Sensation
    Emeran A Mayer; Fiscal Year: 2012
    ..Centrally, it is characterized by enhanced perception of gut stimuli resulting in abdominal pain and discomfort...
  49. Predicting Response to Standardized Pediatric Colitis Therapy: PROTECT Study
    JEFFREY SAMUEL HYAMS; Fiscal Year: 2013
    ..UC causes considerable suffering with abdominal pain, diarrhea, bleeding, and weight loss and for unknown reasons is often more severe in children than adults...
  50. Detection and Diagnosis of Pancreatic Carcinoma
    David V Gold; Fiscal Year: 2013
    ..The most common symptoms of the disease, jaundice, abdominal pain, and weight loss, together with other presenting factors are nonspecific in nature...
  51. Impact of Violence on Obesity & Reproductive Axes in Youth
    Rosalind J Wright; Fiscal Year: 2010
    ..reproductive health outcomes including early menarche, menstrual irregularity, and chronic functional pelvic/abdominal pain. Furthermore, these shared pathways may in part explain the link between obesity and these reproductive ..
  52. Investigation of Giardiasis Using Click Chemistry Techniques
    KEITH ALLEN KORTHALS; Fiscal Year: 2010
    ..threat because it is easily obtained, has a very low infectious dose, and causes severe symptoms such as abdominal pain, diarrhea, and nausea. Metronidazole is the current first line treatment of giardiasis...
  53. Novel Rinse to Treat Oral Candidiasis in Cancer Patients
    Bakul Bhatt; Fiscal Year: 2007
    ..Furthermore, side effects of Fluconazole include nausea, vomiting, abdominal pain, headaches, dizziness, drowsiness, fever, diarrhea, rash and changes in the sense of taste...
  54. Apoptosis Inducing to Enhance Tumor Targeting
    Ze Lu; Fiscal Year: 2012
    ..e., abdominal pain) due to the high local drug concentrations...
  55. Effectiveness and Feasibility of Patient Controlled Analgesia in the ED
    ADRIENNE JEANNE BIRNBAUM; Fiscal Year: 2013
    ..by our group provides promising preliminary support for the efficacy and safety of PCA for patients with abdominal pain at a single ED with a dedicated research nurse and standard loading dose given to all patients...
  56. Evaluating Predictors &Interventions in Sphincter of Oddi Dysfunction (EPISOD)
    Peter B Cotton; Fiscal Year: 2013
    ..encompasses a spectrum of disorders in which dysfunction of the biliary and/or pancreatic sphincters result in abdominal pain. The diagnosis is often considered in patients with biliary-type pain who have previously undergone ..
  57. Serotonin Transporter Gene Re-Sequencing in Patients with Irritable Bowel Sundrom
    Ruth Kohen; Fiscal Year: 2012
    ..Irritable Bowel Syndrome (IBS) is a common chronic gastrointestinal (GI) disorder characterized by symptoms of abdominal pain or discomfort associated with disturbed defecation...
  58. Catastrophizing, Child Pain Behavior, and Parental Response
    Shelby Langer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Functional Abdominal Pain (FAP) of childhood is a disorder for which there is no identifiable organic etiology, yet which is associated with illness behavior of significant personal and societal cost...
  59. Self-Administered CBT for IBS: A Multicenter Trial
    Jeffrey M Lackner; Fiscal Year: 2013
    ..GI disorder for which there is no reliable and satisfactory medical option for its full range of symptoms (abdominal pain, bowel dysfunction)...
  60. CAMPYLOBACTER PYLORIDIS IN GASTRODUODENAL DISEASE
    David Graham; Fiscal Year: 1991
    ..in patients with gastric ulcers, duodenal ulcers, non-ulcer dyspepsia and children with chronic recurrent abdominal pain; 3) the transmission of C...
  61. Rare disease susceptibility alleles in children with Crohn disease
    Stephen L Guthery; Fiscal Year: 2013
    ..Affected children suffer from diarrhea, abdominal pain, growth disturbances, and an impaired quality of life...
  62. Novel Intervention for Colitis
    MICHAEL VITEK; Fiscal Year: 2007
    ..disease and ulcerative colitis, affects approximately 1 million Americans with inflammation of the intestines, abdominal pain, cramping and diarrhea...
  63. Dietary Support for Healthy Digestion in Crohn's Disease
    CAROL S BROTHERTON; Fiscal Year: 2011
    ..and advances in pharmacological treatments, a subset of persons with CD continue to relapse with symptoms of abdominal pain, bleeding, and/or diarrhea reappearing while trying to wean from prednisone therapy...
  64. A MULTI-CHANNEL GASTRIC PACER FOR TREATING GASTROPARESIS
    Robert Ross; Fiscal Year: 2004
    ..In gastroparesis, impaired gastric emptying can lead to nausea, vomiting, premature satiety, abdominal pain, abdominal bloating, weight loss, bacterial overgrowth, and obstruction, as well as difficulties in managing ..
  65. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..of IBS, there are unmet clinical needs and no effective medication approved for the treatment of abdominal pain associated with IBS...
  66. Recurrent Abdominal Pain in Children
    Robert Shulman; Fiscal Year: 2012
    Ten to 17% of children 4-16 years have recurrent abdominal pain (RAP). Of these, up to 68% meet the criteria for irritable bowel syndrome (IBS), which also affects 15- 20% of adults. Up to 66% of children with RAP develop IBS as adults...
  67. Brain mechanisms underlying selective attention in IBS
    Jennifer S Labus; Fiscal Year: 2010
    ..Irritable bowel syndrome is a common, chronic functional gastrointestinal disorder, characterized by abdominal pain and altered bowel habits, with significant impact on health-related quality of life and health care ..
  68. SYNAPTIC TRANSMISSION IN DIABETIC ENTERIC NERVOUS SYSTEM
    KATHY LEPARD; Fiscal Year: 2001
    ..range of GI discomforts including heartburn, nausea, vomiting, diarrhea, constipation, fecal incontinence and abdominal pain. Many patients have abnormalities in motility arising from identifiable conditions; but over 50% of GI ..
  69. THE UNSUSPECTED SMALL STONE STUDY (USSS)
    James DiSario; Fiscal Year: 2000
    ..Secondary endpoints include rates of severe morbidity, mortality, abdominal pain, jaundice, abnormal serum liver tests, abnormal transcutaneous abdominal ultrasound examinations, quality of ..
  70. Slowing of Transit - The Third Enteric Function of 5-HT
    Henry Lin; Fiscal Year: 2005
    ..b>Abdominal pain, nausea, bloating, diarrhea and malnutrition are the consequences of impaired control of intestinal transit...
  71. Safety and Efficacy of Patient Controlled Analgesia in the Emergency Department
    Polly Bijur; Fiscal Year: 2009
    ..210 ED patients ages 18 through 65 years with abdominal pain requiring intravenous opioid analgesia will be enrolled in a randomized double-blind placebo-controlled study...
  72. Pioglitazone Therapy for Endocrine and Exocrine Disease in Alcoholic Pancreatitis
    MATTHEW DIMAGNO; Fiscal Year: 2009
    ..a progressive clinical disease involving endocrine and exocrine pancreas dysfunction and causing debilitating abdominal pain. "Benign" pancreatic diseases, including CP, affect 5-24 million in the U.S. and cost up to $2...
  73. GDNF in the Enteric Nervous System
    Yun Xia; Fiscal Year: 2007
    ..Parkinsonian patients in recombinant GDNF therapy trials experienced IBS-like diarrhea and cramping abdominal pain. Human trials showed evidence of a prokinetic action on gastrointestinal transit...
  74. NOVEL PROTEASE FORMULATION BASED ON CROSSLINKED CRYSTALS
    Bhami Shenoy; Fiscal Year: 2004
    ..formulation of protease from Aspergillus melleus, TheraCLEC-Protease, for use in the treatment of chronic abdominal pain in chronic pancreatitis and also along with TheraCLEC-Lipase and amylase for the treatment of malabsorption as ..
  75. Novel non-invasive treatment for hypotension during hemodialysis
    Anja Metzger; Fiscal Year: 2007
    ..IDH often causes abdominal pain, nausea, vomiting, muscle cramps, dizziness and fainting, slows or terminates the dialysis run, reduces the ..
  76. NC/OFQ analogs as ORL1 agonists to promote gut motility
    MARK FINDEIS; Fiscal Year: 2005
    ..POI is a condition characterized by a lack of bowel motility, abdominal pain, and nausea...
  77. mu Opioid Receptor Function in the Enteric Nervous System
    Catia Sternini; Fiscal Year: 2007
    ..of opiates, potent drugs used for pain control, including analgesia, opioid bowel syndrome (constipation and abdominal pain), and tolerance...
  78. Abdominal Symptom Phenotypes: Pathways to New Biomarkers
    Robert Shulman; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Functional gastrointestinal disorders, in particular functional abdominal pain (FAP) in children and adults and irritable bowel syndrome (IBS) in adults, are among the most common and ..