spasm

Summary

Summary: An involuntary contraction of a muscle or group of muscles. Spasms may involve skeletal muscle (MUSCLE, SKELETAL) or smooth muscle (MUSCLE, SMOOTH).

Top Publications

  1. ncbi Cricopharyngeal spasm and Zenker's diverticulum
    Elizabeth A Veenker
    Oregon Health and Sciences University, Department of Otolaryngology Head and Neck Surgery, 3181 SW Sam Jackson Park Rd, Portland, Oregon 97201 3098, USA
    Head Neck 25:681-94. 2003
  2. ncbi Prophylactic tolperisone for post-exercise muscle soreness causes reduced isometric force--a double-blind randomized crossover control study
    Prem Bajaj
    Laboratory for Experimental Pain Research, Centre for Sensory Motor Interaction, Fredrick Bajers VEJ 7 D3, Aalborg University, Denmark DK 9220
    Eur J Pain 7:407-18. 2003
  3. pmc Smooth muscle cell-extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan-deficient cardiomyopathy
    Matthew T Wheeler
    Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60673, USA
    J Clin Invest 113:668-75. 2004
  4. ncbi Botulinum toxin type A for chronic pain and pelvic floor spasm in women: a randomized controlled trial
    Jason A Abbott
    University of New South Wales, Sydney Australia
    Obstet Gynecol 108:915-23. 2006
  5. ncbi Low back ache treatment with botulinum neurotoxin type A. Local experience in Kuwait
    Venkatesan Nagarajan
    Department of Neurology, Ibn Sina Hospital, Kuwait, Kuwait
    Med Princ Pract 16:181-6. 2007
  6. ncbi Assessment of the efficacy of phentolamine to prevent radial artery spasm during cardiac catheterization procedures: a randomized study comparing phentolamine vs. verapamil
    Rafael J Ruiz-Salmerón
    Department of Interventional Cardiology, Hospital Clinic i Provincial, Barcelona, Spain
    Catheter Cardiovasc Interv 66:192-8. 2005
  7. ncbi A simple and effective regimen for prevention of radial artery spasm during coronary catheterization
    Chih Wei Chen
    Section of Cardiology, Department of Internal Medicine, Buddhist Tzuchi Dalin General Hospital, Chia Yi, Taiwan, ROC
    Cardiology 105:43-7. 2006
  8. pmc Botulinum toxin in clinical practice
    J Jankovic
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurol Neurosurg Psychiatry 75:951-7. 2004
  9. ncbi Evaluation of a spasmolytic cocktail to prevent radial artery spasm during coronary procedures
    Ferdinand Kiemeneij
    Amsterdam Department of Interventional Cardiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Catheter Cardiovasc Interv 58:281-4. 2003
  10. ncbi Painful tonic spasm in neuromyelitis optica: incidence, diagnostic utility, and clinical characteristics
    Sung Min Kim
    Department of Neurology, Seoul National University College of Medicine, Korea
    Arch Neurol 69:1026-31. 2012

Detail Information

Publications230 found, 100 shown here

  1. ncbi Cricopharyngeal spasm and Zenker's diverticulum
    Elizabeth A Veenker
    Oregon Health and Sciences University, Department of Otolaryngology Head and Neck Surgery, 3181 SW Sam Jackson Park Rd, Portland, Oregon 97201 3098, USA
    Head Neck 25:681-94. 2003
    Cricopharyngeal spasm and Zenker's diverticulum represent disorders of the pharyngoesophageal junction for which a unifying theory of etiology has yet to be established...
  2. ncbi Prophylactic tolperisone for post-exercise muscle soreness causes reduced isometric force--a double-blind randomized crossover control study
    Prem Bajaj
    Laboratory for Experimental Pain Research, Centre for Sensory Motor Interaction, Fredrick Bajers VEJ 7 D3, Aalborg University, Denmark DK 9220
    Eur J Pain 7:407-18. 2003
    The role of tolperisone hydrochloride, a centrally acting muscle relaxant in relieving painful muscle spasm is recently being discussed...
  3. pmc Smooth muscle cell-extrinsic vascular spasm arises from cardiomyocyte degeneration in sarcoglycan-deficient cardiomyopathy
    Matthew T Wheeler
    Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60673, USA
    J Clin Invest 113:668-75. 2004
    Vascular spasm is a poorly understood but critical biomedical process because it can acutely reduce blood supply and tissue oxygenation...
  4. ncbi Botulinum toxin type A for chronic pain and pelvic floor spasm in women: a randomized controlled trial
    Jason A Abbott
    University of New South Wales, Sydney Australia
    Obstet Gynecol 108:915-23. 2006
    To estimate whether botulinum toxin type A is more effective than placebo at reducing pain and pelvic floor pressure in women with chronic pelvic pain and pelvic floor muscle spasm.
  5. ncbi Low back ache treatment with botulinum neurotoxin type A. Local experience in Kuwait
    Venkatesan Nagarajan
    Department of Neurology, Ibn Sina Hospital, Kuwait, Kuwait
    Med Princ Pract 16:181-6. 2007
    ..To investigate the efficacy, safety and tolerability of paraspinal administration of botulinum neurotoxin type A (BoNT-A) in patients with chronic low back ache (LBA)...
  6. ncbi Assessment of the efficacy of phentolamine to prevent radial artery spasm during cardiac catheterization procedures: a randomized study comparing phentolamine vs. verapamil
    Rafael J Ruiz-Salmerón
    Department of Interventional Cardiology, Hospital Clinic i Provincial, Barcelona, Spain
    Catheter Cardiovasc Interv 66:192-8. 2005
    ..Radial artery spasm is a relatively frequent complication during transradial approach, causing patient discomfort or even making it ..
  7. ncbi A simple and effective regimen for prevention of radial artery spasm during coronary catheterization
    Chih Wei Chen
    Section of Cardiology, Department of Internal Medicine, Buddhist Tzuchi Dalin General Hospital, Chia Yi, Taiwan, ROC
    Cardiology 105:43-7. 2006
    Radial artery spasm occurs frequently during the transradial approach for coronary catheterization. Premedications with nitroglycerin and verapamil have been documented to be effective in preventing radial spasms...
  8. pmc Botulinum toxin in clinical practice
    J Jankovic
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurol Neurosurg Psychiatry 75:951-7. 2004
    ..Long term experience with this agent suggests that it is an effective and safe treatment not only for approved indications but also for an increasing number of off-label indications...
  9. ncbi Evaluation of a spasmolytic cocktail to prevent radial artery spasm during coronary procedures
    Ferdinand Kiemeneij
    Amsterdam Department of Interventional Cardiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Catheter Cardiovasc Interv 58:281-4. 2003
    Radial artery spasm is a frequent complication of the transradial approach for coronary angiography and angioplasty. Recently, we have been able to quantify spasm using the automatic pullback device...
  10. ncbi Painful tonic spasm in neuromyelitis optica: incidence, diagnostic utility, and clinical characteristics
    Sung Min Kim
    Department of Neurology, Seoul National University College of Medicine, Korea
    Arch Neurol 69:1026-31. 2012
    To evaluate the diagnostic utility and clinical characteristics of painful tonic spasm (PTS) in neuromyelitis optica (NMO).
  11. ncbi Measurement of radial artery spasm using an automatic pullback device
    F Kiemeneij
    Amsterdam Department of Interventional Cardiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Catheter Cardiovasc Interv 54:437-41. 2001
    Current evaluation of radial artery spasm (RAS), a frequent finding during the transradial approach for coronary angiography and angioplasty (TRA), is subjective...
  12. ncbi Persistent hand spasm: movement disorder or seizure?
    Deidre A De Silva
    Department of Neurology, Singapore General Hospital, Outram Road, 169608, Singapore
    J Neurol Sci 252:185-8. 2007
    ..We report an elderly lady with intractable focal seizure who presented with more than a year of persistent hand spasms. The clinical importance of differentiating epilepsy from movement disorders is discussed...
  13. ncbi Comparative study of nicorandil and a spasmolytic cocktail in preventing radial artery spasm during transradial coronary angiography
    Seong Hwan Kim
    Division of Cardiology, Department of Internal Medicine, Hallym University Medical Center, 94 200, Yeongdeungpo dong, Yeongdeungpo gu, 150 030, Seoul, Republic of Korea
    Int J Cardiol 120:325-30. 2007
    Radial artery spasm is one of the most common complications during coronary angiography via the transradial approach, causing patient discomfort or sometimes interrupting the procedure...
  14. ncbi Clinical assessment of usefulness, effectiveness and safety of jackyakamcho-tang (shaoyaogancao-tang) on muscle spasm and pain: a case series
    Woo Sang Jung
    Department of Cardiovascular and Neurologic Diseases Stroke Center, College of Oriental Medicine Kyung Hee University, Seoul, Korea
    Am J Chin Med 32:611-20. 2004
    ..Two hundred and thirty-seven patients were treated with jackyakamcho-tang (JKT) for relief of muscle spasm and pain; 81 of them were included in analysis...
  15. ncbi Radial artery spasm during transradial coronary procedures
    Ivica Kristić
    University Hospital Split, Division of Cardiology, Department of Internal Medicine, Split, Croatia
    J Invasive Cardiol 23:527-31. 2011
    ..Radial artery spasm (RAS) is an important limitation of TRA...
  16. ncbi Impact of length and hydrophilic coating of the introducer sheath on radial artery spasm during transradial coronary intervention: a randomized study
    Sudhir Rathore
    Department of Cardiology, Liverpool Heart and Chest Hospital, Liverpool, UK
    JACC Cardiovasc Interv 3:475-83. 2010
    ..of this study was to assess the impact of length and hydrophilic coating of the introducer sheath on radial artery spasm, radial artery occlusion, and local vascular complications in patients undergoing transradial coronary procedures.
  17. ncbi Intermediate fixed coronary artery stenosis at the site of ergonovine-provoked spasm as a predictor of long-term major adverse cardiac events of patients with coronary spastic angina
    Shinya Nishizawa
    Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, and Department of Cardiology, Kyoto First Red Cross Hospital, Kyoto, Japan
    Circ J 73:699-704. 2009
    ..a significant prognostic factor in patients with coronary spastic angina (CSA), so the present study was focused on assessing the impact of intermediate fixed stenosis at sites of provoked spasm on the long-term outcomes of CSA patients.
  18. pmc C-reactive protein for predicting prognosis and its gender-specific associations with diabetes mellitus and hypertension in the development of coronary artery spasm
    Ming Jui Hung
    Department of Cardiology, Chang Gung Memorial Hospital, Keelung, Chang Gung University College of Medicine, Taoyuan, Taiwan
    PLoS ONE 8:e77655. 2013
    While hypertension is negatively associated with coronary artery spasm (CAS), scarce data are available on diabetes mellitus in relation to CAS...
  19. ncbi Hyoscine butylbromide - a review on its parenteral use in acute abdominal spasm and as an aid in abdominal diagnostic and therapeutic procedures
    Guido N Tytgat
    Academisch Medisch Centrum, Amsterdam, The Netherlands
    Curr Med Res Opin 24:3159-73. 2008
    ..with this antispasmodic dates back to the 1950s and led to its registration for treating abdominal cramps/spasm and for diagnostic imaging purposes...
  20. ncbi Botulinum neurotoxin for pharyngeal constrictor muscle spasm in tracheoesophageal voice restoration
    Ronald C Hamaker
    Head and Neck Surgery Associates, Indianapolis, Indiana, USA
    Laryngoscope 113:1479-82. 2003
    The purpose of the study was to evaluate the effectiveness of Botulinum neurotoxin (Botox) for elimination of pharyngeal constrictor muscle spasm in tracheoesophageal voice restoration.
  21. ncbi [Acupuncture for the lower extremity spasm induced by spinal injury: random controlled trial of single case]
    Wei Wei Chen
    Department of Integrated Chinese and Western Medicine, Huaxi Hospital, Sichuan University, Chengdu 610041, China
    Zhongguo Zhen Jiu 30:473-7. 2010
    To study whether acupuncture on the acupoints of the affected extremities was effective or not on the lower extremity spasm in spinal injury, and observe the tolerance of patients to acupuncture.
  22. ncbi Neuroparalysis and ventilatory support in severe tetanus
    T K Dutta
    Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry
    J Indian Med Assoc 104:63-6. 2006
    ..Mean period of onset ie, period from trismus to first spasm, in these patients was 24 hours...
  23. ncbi Camptocormia: pathogenesis, classification, and response to therapy
    Shaheda N Azher
    Parkinson s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Neurology 65:355-9. 2005
    ....
  24. ncbi Botulinum toxin for the treatment of musculoskeletal pain and spasm
    Geoffrey Sheean
    EMG and Neuromuscular Service, University of California, San Diego, 200 West Arbor Drive, San Diego 92103 8465, USA
    Curr Pain Headache Rep 6:460-9. 2002
    ..However, even if botulinum toxin is firmly established as an analgesic, there is insufficient clinical evidence of its efficacy in treating non-neurologic, chronic, musculoskeletal pain conditions...
  25. ncbi An alternative application of sodium nitroprusside to overcome perioperative spasm of the internal thoracic artery
    C Yorgancioglu
    Bayindir Medical Center, Department of Cardiovascular Surgery, Sogutozu, 06520, Ankara, Turkey
    Cardiovasc Surg 9:64-67. 2001
    ..Pedicle preparation and pharmacological vasodilatory treatment vary greatly. This clinical study was performed in order to define the effectiveness of two different applications of sodium nitroprusside as vasodilating agent...
  26. ncbi [A case of convergence spasm in hysteria improved with a brief psychiatric assessment]
    A Suzuki
    Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
    No To Shinkei 53:1141-4. 2001
    ..The rest of the neurologic examinations were normal. We thought that she had a convergence spasm. Brain CT and MRI were normal. The CSF and blood chemistries were also normal...
  27. pmc Harmonic scalpel versus electrocautery for harvest of radial artery conduits: reduced risk of spasm and intimal injury on optical coherence tomography
    Philip S Brazio
    Division of Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
    J Thorac Cardiovasc Surg 136:1302-8. 2008
    ..coherence tomography, a catheter-based intravascular imaging modality, to measure the degree of radial artery spasm induced by means of harvest with electrocautery or a harmonic scalpel in patients undergoing coronary artery ..
  28. ncbi [Radial artery spasm in transradial cardiac catheterization. Assessment of factors related to its occurrence, and of its consequences during follow-up]
    Rafael J Ruiz-Salmerón
    Departamento de Hemodinámica y Cardiología Intervencionista, Hospital Clinic, Barcelona, Espana
    Rev Esp Cardiol 58:504-11. 2005
    Radial artery spasm is the most frequent complication of transradial cardiac catheterization. It causes patient discomfort and reduces the procedure's success rate...
  29. ncbi Cardiac arrest related to coronary spasm in patients with variant angina: a three-case study
    W Seniuk
    Cardiology Department, Karol Marcinkowski University School of Medical Sciences, ul Starowiejska 1g 3, 61 664 Poznań, Poland
    J Intern Med 252:368-76. 2002
    ..All of them had typical clinical symptoms, ST-segment changes in electrocardiogram, and coronary artery spasm confirmed by arteriography. They were treated with high doses of calcium antagonists and nitrates...
  30. ncbi Clinical impact of selective spasm provocation tests: comparisons between acetylcholine and ergonovine in 1508 examinations
    Shozo Sueda
    Department of Cardiology, Saiseikai Saijo HospitalbDepartment of Cardiology, Kita Medical Association Hospital, Ehime, Japan
    Coron Artery Dis 15:491-7. 2004
    There are few reports regarding the concordance of coronary arterial response between acetylcholine (ACh) and ergonovine (ER) spasm provocation tests.
  31. ncbi Modulatory effect of diclofenac on antispasmodic effect of pitofenone in cholinergic spasm
    Shrinivas K Kulkarni
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India
    Indian J Exp Biol 42:567-9. 2004
    Biliary, ureteric and intestinal colic are extremely common clinical conditions associated with smooth muscle spasm. In the present study, antispasmodic activity was carried out against acetylcholine (10-640 ng/ml)-induced contractions ..
  32. ncbi Spasm of the near reflex in a patient with multiple sclerosis
    Sumit Sitole
    Department of Ophthalmology, Loyola University Medical Center, Maywood, IL 60153, USA
    Semin Ophthalmol 22:29-31. 2007
    ..Symptomatic relief was achieved by cycloplegia and spectacle correction...
  33. ncbi Cyclobenzaprine ER for muscle spasm associated with low back and neck pain: two randomized, double-blind, placebo-controlled studies of identical design
    Gerard A Malanga
    Atlantic Health, Overlook Hospital, Summit, NJ 07901, USA
    Curr Med Res Opin 25:1179-96. 2009
    To evaluate efficacy and tolerability of once-daily cyclobenzaprine extended release (CER) 15- and 30-mg capsules in patients with muscle spasm associated with acute, painful musculoskeletal conditions.
  34. ncbi Botulinum toxin in spasticity treatment in adults
    A B Ward
    University Hospital of North Staffordshire NHS Trust, Burslem, Stoke on Trent ST6 7AG
    Nervenarzt 79:22-3. 2008
  35. ncbi Treatment of juvenile spasticity with botulinum toxin type A
    K Desloovere
    Department of Rehabilitation Sciences, Katholieke Universiteit, Leuven
    Nervenarzt 79:19-21. 2008
  36. ncbi Efficacy of thiocolchicoside in Indian patients suffering from low back pain associated with muscle spasm
    Darius F Soonawalla
    Breach Candy Hospital, Mumbai 400026
    J Indian Med Assoc 106:331-5. 2008
    Low back pain (LBP), a high prevalent condition among middle aged population, is usually associated with 'muscle spasm' that is responsible for giving rise to pain as well as its persistence...
  37. ncbi Flash pulmonary edema heralding renal artery spasm
    Mohammad Bagher Sharifkazemi
    Department of Cardiology, Shiraz University of Medical Sciences, Shiraz, Iran
    Cardiology 109:66-7. 2008
    ..We describe a patient with clinical presentation of flash pulmonary edema due to renal artery spasm. To the best of our knowledge, this is the first reported case of flash pulmonary edema due to renal artery spasm.
  38. ncbi Accommodative spasm after laser-assisted in situ keratomileusis (LASIK)
    Suzanna Airiani
    Edward S Harkness Eye Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Ophthalmol 141:1163-4. 2006
    To report a case of accommodative spasm following laser-assisted in situ keratomileusis (LASIK).
  39. ncbi Botulinum toxin for treating spasmodic dysphonia (laryngeal dystonia): a systematic Cochrane review
    Christopher Watts
    Department of Communication Sciences and Disorders, James Madison University, Harrisonburg, VA 22840, USA
    Clin Rehabil 20:112-22. 2006
    ..Botulinum toxin is currently the gold standard of treatment...
  40. ncbi Spasm of accommodation associated with closed head trauma
    R V Paul Chan
    The Departments of Ophthalmology Kellogg Eye Center and Neurology, University of Michigan Medical Center, 1000 Wall Street, Ann Arbor, MI 48105, USA
    J Neuroophthalmol 22:15-7. 2002
    b>Spasm of accommodation, creating pseudomyopia, is generally associated with miosis and excess convergence as part of spasm of the near reflex. It may also exist as an isolated entity, usually attributed to psychogenic causes...
  41. ncbi Facial palsy, postparalytic facial syndrome, and hemifacial spasm
    Josep Valls-Sole
    Servei de Neurologia, Hospital Clinic, Universitat de Barcelona, and Institut d Investigació Biomèdica August Pi i Sunyer, Barcelona, Spain
    Mov Disord 17:S49-52. 2002
  42. ncbi Efficacy and tolerance of repeated oral doses of tolperisone hydrochloride in the treatment of painful reflex muscle spasm: results of a prospective placebo-controlled double-blind trial
    H G Pratzel
    Institut für Medizinische Balneologie und Klimatologie, LMU IMBK, Munchen, Germany
    Pain 67:417-25. 1996
    The efficacy and safety of oral tolperisone hydrochloride (Mydocalm) in the treatment of painful reflex muscle spasm was assessed in a prospective, randomized, double-blind, placebo-controlled trial...
  43. ncbi Botulinum toxin A and chronic low back pain: a randomized, double-blind study
    L Foster
    Department of Physical Medicine and Rehabilitation, Walter Reed Army Medical Center, Washington, DC, USA
    Neurology 56:1290-3. 2001
    ..011). No patient experienced side effects. CONCLUSION: Paravertebral administration of botulinum toxin A in patients with chronic low back pain relieved pain and improved function at 3 and 8 weeks after treatment...
  44. ncbi Relief by naloxone of morphine-induced spasm of the sphincter of Oddi in a post-cholecystectomy patient
    K C Butler
    Department of Emergency Medicine, Maricopa Medical Center, Phoenix, Arizona 85008, USA
    J Emerg Med 21:129-31. 2001
    b>Spasm of the sphincter of Oddi is a well-recognized effect of the narcotic class of drugs. Although it is usually clinically silent, such spasm occasionally causes debilitating pain that may be mistaken for more serious disorders...
  45. ncbi Surgical and nonsurgical treatment options in patients with movement disorders of the platysma
    Rainer Laskawi
    ENT Department, University of Gottingen, Gottingen, Germany
    J Oral Maxillofac Surg 60:157-62. 2002
    ..This article describes the different treatment options for movement disorders of the platysma...
  46. ncbi Intrathecal baclofen in the treatment of painful, disabling spasms in Friedreich's ataxia
    Djamel Ben Smail
    Service de médecine physique et réhabilitation, Hôpital R Poincaré, 104 Boulevard R Poincaré, 92380 Garches, France
    Mov Disord 20:758-9. 2005
    ..To our knowledge, this is the first report of an intrathecal baclofen-delivering pump implantation in an FA patient...
  47. ncbi Spasmodic dysphonia combined with insufficient glottic closure by phonation
    Z Kaszas
    Szent Rókus Hospital and Institutions, Department of Otorhinolaryngology and Head and Neck Surgery, Gyulai Pál u 2, 1085 Budapest, Hungary
    Eur Arch Otorhinolaryngol 260:418-20. 2003
    ..The result of the two-step procedure was a fluent and clear voice. The speech without interruption lasted for 5 months, until the drug was eliminated. Of course, to prolong the result, the Botox injection should be repeated...
  48. ncbi [Botulinum toxin A and musculoskeletal pain]
    M P De Sèze
    Service de Medecine Physique et de Readaptation, hôpital Tastet Girard Pellegrin, CHU de Bordeaux, 33076 Bordeaux, France
    Ann Readapt Med Phys 46:329-32. 2003
    ..The aim of this article was to collect literature data and to assess the different analgesia indications of BTXA proposed in the treatment of musculoskeletal pains...
  49. ncbi [Restorative treatment of degenerative-dystrophic diseases of large joints]
    V A Neverov
    Vestn Khir Im I I Grek 163:97-8. 2004
    ..The authors performed courses of treatment with Midocalm in 110 patients according to their original method. It reduced the pain syndrome, increased the volume of movements in the joint and shortened the time of treatment...
  50. pmc Botulinum toxin infiltration for pain control after mastectomy and expander reconstruction
    Rakhshanda Layeeque
    Department of Surgery, Division of Breast Surgical Oncology, University of Arkansas for Medical Sciences, Arkansas Cancer Research Center, and the Central Arkansas Veterans Hospital System, Little Rock, Arkansas, USA
    Ann Surg 240:608-13; discussion 613-4. 2004
    We hypothesized botulinum toxin (BT) infiltration of the chest wall musculature after mastectomy would create a prolonged inhibition of muscle spasm and postoperative pain, facilitating tissue expander reconstruction.
  51. ncbi Use of botulinum toxin type A on orthopedics: a case report
    Ana Sáenz
    Rehabilitation Department, Hospital Nostra Senyora de Meritxell, Andorra, Spain
    Arch Phys Med Rehabil 84:1085-6. 2003
    ..This improvement enabled the patient to resume his job as a building supervisor, which required active involvement in physical construction work...
  52. ncbi Isaacs' syndrome: clinical and electrophysiological response to gabapentin
    Upinder K Dhand
    Department of Neurology, University of Missouri, M178, Columbia, Missouri 65212, USA
    Muscle Nerve 34:646-50. 2006
    ..Subsequent nerve conduction studies showed decreased amplitude and later an absence of M-wave afterdischarges. Gabapentin thus appears to be an effective treatment for Isaacs' syndrome...
  53. pmc Temporal facilitation of spastic stretch reflexes following human spinal cord injury
    T George Hornby
    Department of Physical Therapy, University of Illinois at Chicago, 1919 W Taylor St 4th floor, M C 898, Chicago, IL 60612, USA
    J Physiol 571:593-604. 2006
    ..Evidence of stretch reflex facilitation post-SCI may reflect changes in underlying neuronal properties and provide insight into the mechanisms underlying spastic reflexes...
  54. ncbi Head and neck muscle spasm after radiotherapy: management with botulinum toxin A injection
    Douglas J Van Daele
    Department of Otolaryngology Head and Neck Surgery, University of Iowa Health Care, Iowa City 52242, USA
    Arch Otolaryngol Head Neck Surg 128:956-9. 2002
    To introduce the concept of neck muscle pain and spasm after radiotherapy and its treatment with botulinum toxin A.
  55. ncbi Acquired neuromyotonia in childhood: case report and review
    Gabriel Gonzalez
    Department of Pediatric Neurology, Pereira Rossell Children s Hospital, Montevideo, Uruguay
    Pediatr Neurol 38:61-3. 2008
    ..This report describes Isaacs' syndrome in a child, in whom the diagnosis was made by clinical features of acquired, spontaneous muscle overactivity and typical electromyographic findings...
  56. ncbi [Efficacy at six months of the botulinum toxin A in the post-stroke lower limb's muscular overactivity]
    A Yelnik
    Service de Medecine Physique et de Readaptation, Groupe Hospitalier Lariboisiere F Widal, 200, rue du Faubourg Saint Denis, 75010, Paris, France
    Ann Readapt Med Phys 45:159-65. 2002
    ..Post-stroke hemiplegic patients are often disabled by a muscular overactivity of the lower limb which can be treated by botulinum toxin A (BTX). The aim of this study was to assess the length of this efficiency as expressed by the patient...
  57. ncbi Singer's dystonia: first report of a variant of spasmodic dysphonia
    Ajay Chitkara
    New York Center for Voice and Swallowing Disorders, New York, New York, USA
    Ann Otol Rhinol Laryngol 115:89-92. 2006
    ..We discuss the phonatory characteristics of a previously undescribed focal laryngeal dystonia present in the singing voice...
  58. ncbi Flexor reflex responses triggered by imposed knee extension in chronic human spinal cord injury
    Ming Wu
    Sensory Motor Performance Program, Rehabilitation Institute of Chicago, IL 60611, USA
    Exp Brain Res 168:566-76. 2006
    ..These results suggest that spasticity in SCI consists of a myriad of complex reflex responses that extend beyond stretch reflexes...
  59. ncbi Static load repetition is a risk factor in the development of lumbar cumulative musculoskeletal disorder
    Paola Sbriccoli
    Occupational Medicine Research Center, Bioengineering Laboratory, Department of Orthopaedic Surgery, LA State University Health Sciences Center, New Orleans, LA 70112, USA
    Spine (Phila Pa 1976) 29:2643-53. 2004
    ..In vivo feline model subjected to variable number of repetitions of a short static lumbar flexion followed by an equally long rest period...
  60. ncbi Progressive arm weakness and tonic hand spasm from multifocal motor neuropathy in the brachial plexus
    R Veltkamp
    Department of Neurology, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Muscle Nerve 28:242-5. 2003
    ..Strength recovered and cramps disappeared after intravenous immunoglobulins. Motor neuropathies may thus manifest with features of central motor disorders...
  61. ncbi [Multidisciplinary therapy for focal spasticity treatment]
    J Wissel
    Neurologische Rehabilitationsklinik Beelitz Heilstätten, Kliniken Beelitz GmbH, Beelitz Heilstätten
    Nervenarzt 79:24-8. 2008
    ..The goals of focal therapy for spasticity should be discussed with the patient and family members to guarantee maximum results from the coordinated multidisciplinary effort of BTA-treatment in disabling spasticity...
  62. ncbi Reflex periodic spasms induced by eating
    Angelo Labate
    Institute of Neurology, University Magna Graecia Catanzaro, Catanzaro, Italy
    Brain Dev 28:170-4. 2006
    ....
  63. ncbi Contribution of muscle afferents to prolonged flexion withdrawal reflexes in human spinal cord injury
    T G Hornby
    Department of Physical Therapy, University of Illinois, Chicago, Illinois 60612, USA
    J Neurophysiol 92:3375-84. 2004
    ..m. TA stimulation. Results after i.m. GS stimulation indicate multi-joint flexion reflexes can also be elicited, although to a lesser extent than i.m. TA stimulation...
  64. pmc Treatment of stiff person syndrome with rituximab
    M R Baker
    Department of Neurology, Royal Victoria Infirmary Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK
    J Neurol Neurosurg Psychiatry 76:999-1001. 2005
    ..The disease had progressed despite a favourable initial response to conventional treatment with intravenous immunoglobulin and cytotoxics. Treatment with rituximab induced a lasting clinical remission...
  65. ncbi Frequency of cyclic lumbar loading is a risk factor for cumulative trauma disorder
    Dawei Lu
    Musculoskeletal Disorders Research Laboratory, Bioengineering Division, Department of Orthopaedic Surgery, University of Colorado at Denver Health Sciences Center, 12800 East 19th Avenue, Aurora, CO 80045, USA
    Muscle Nerve 38:867-74. 2008
    ..We suggest that workers avoid high-frequency exposure to cyclic activity in order to prevent the development of cumulative trauma disorder...
  66. ncbi Motor unit firing during and after voluntary contractions of human thenar muscles weakened by spinal cord injury
    Inge Zijdewind
    Department of Medical Physiology, University of Groningen, The Netherlands
    J Neurophysiol 89:2065-71. 2003
    ..3 to 7.2% maximum. Subjects were unable to stop this involuntary unit activity even with the help of feedback. The mechanisms that underlie this prolonged motor unit firing need to be explored further...
  67. ncbi Role of motoneurons in the generation of muscle spasms after spinal cord injury
    Monica A Gorassini
    Department of Biomedical Engineering, Centre for Neuroscience, University of Alberta, Edmonton, Canada
    Brain 127:2247-58. 2004
    ..synaptic drive, or control unit firing rate, required to recruit a test motor unit at the onset of a muscle spasm was significantly higher (by 43%) than the estimated synaptic drive during de-recruitment at the end of a muscle ..
  68. ncbi [Botulinum: fashionable drug and effective medication. What the "miracle weapon against crow's feet" can do in addition]
    Peter Stiefelhagen
    MMW Fortschr Med 145:4-6. 2003
  69. ncbi Effects of experimental muscle pain on electromyographic activity of masticatory muscles in the rat
    Jin Y Ro
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Baltimore School of Dentistry, 666 West Baltimore Street, Baltimore, Maryland 21201, USA
    Muscle Nerve 25:576-84. 2002
    ..Therefore, the development and maintenance of chronic jaw muscle pain does not appear to result from a feedback cycle mechanism...
  70. ncbi Botulinum toxin A in anal fissure: why does it work?
    Wolfgang H Jost
    Dis Colon Rectum 47:257-8. 2004
  71. ncbi Pilot study of botulinum toxin type A in the treatment of chronic pelvic pain associated with spasm of the levator ani muscles
    Sherin K Jarvis
    Department of Endo Gynaecology, Royal Hospital for Women, University of New South Wales, Sydney, Australia
    Aust N Z J Obstet Gynaecol 44:46-50. 2004
    To investigate whether botulinum toxin type A (BOTOX) injected into the levator ani muscles of women with objective pelvic floor muscle spasm decreases pain symptoms and improves quality of life.
  72. ncbi Multicenter, randomized, double-blinded, placebo-controlled trial of thiocolchicoside in acute low back pain
    Fikret Tuzun
    Department of Physical Medicine and Rehabilitation, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    Joint Bone Spine 70:356-61. 2003
    ..To evaluate the efficacy of intramuscular injection of thiocolchicoside (4 mg-2 ml) compared to placebo administered twice daily for 5 days in patients suffering from acute low back pain...
  73. ncbi Guided intrathecal baclofen administration by using soleus stretch reflex in moderate-severe spastic multiple sclerosis patients with implanted pump
    J F Nielsen
    Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark
    Mult Scler 10:521-5. 2004
    ..The soleus stretch reflex might be useful in situations when there is doubt about the effect of intrathecally administered baclofen...
  74. ncbi Efficacy of a low-dose regimen of cyclobenzaprine hydrochloride in acute skeletal muscle spasm: results of two placebo-controlled trials
    David G Borenstein
    The George Washington University Medical Center, Washington, DC 20006, USA
    Clin Ther 25:1056-73. 2003
    Cyclobenzaprine hydrochloride is a muscle relaxant that is effective in improving muscle spasm, reducing local pain and tenderness, and increasing range of motion in acute, painful musculoskeletal conditions...
  75. ncbi Double-blind, placebo-controlled trial of carisoprodol 250-mg tablets in the treatment of acute lower-back spasm
    Lee Ralph
    San Diego Sports Medicine and Family Health Center, San Diego, CA 92120, USA
    Curr Med Res Opin 24:551-8. 2008
    ..NJ, USA), a centrally acting skeletal muscle relaxant used to treat acute, painful musculoskeletal conditions, at a dosage of 250 mg three times daily and at bedtime in patients with acute, painful muscle spasm of the lower back.
  76. ncbi Alteration of central motor excitability in a patient with hemimasticatory spasm after treatment with botulinum toxin injections
    Pablo Mir
    Sobell Department of Movement Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 21:73-8. 2006
    Hemimasticatory spasm (HMS) is a condition characterized by paroxysmal involuntary contraction of masticatory muscles...
  77. ncbi Usefulness of subcutaneous nitrate for radial access
    Anissa Ouadhour
    Coronary Care Unit, Department of Cardiology, Lariboisiere Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Catheter Cardiovasc Interv 72:343-6. 2008
    ..We made the hypothesis that adjunction of nitrate to lidocaine for local anesthesia may facilitate accessibility of radial access...
  78. ncbi Acute posttraumatic ischemia of the limbs: algodystrophy or related syndrome? A prospective study on a series of 25 patients
    Marc Antoine Pistorius
    Department of Internal and Vascular Medicine, University Hospital Hotel Dieu, Nantes, France
    Angiology 59:301-5. 2008
    ..The symptoms may recur, but they respond to physiotherapy. Patients' follow-up showed that microcirculatory function remains abnormal sometime after the initial episode with, in particular, an exacerbation of the venoarteriolar reflex...
  79. ncbi [Pain in multiple sclerosis--a still underestimated problem. The 1 year prevalence of pain syndromes, significance and quality of care of multiple sclerosis inpatients]
    W Pöllmann
    Marianne Strauss Klinik, Berg
    Nervenarzt 75:135-40. 2004
    ..This was even true for the most frequent pain, migraine, in which clear treatment recommendations exist. There is thus an urgent need for physicians to keep this problem in mind when treating MS patients...
  80. ncbi Impact of new technologies on the clinical and functional outcome of Altemeier's procedure: a randomized, controlled trial
    Paolo Boccasanta
    Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS Foundation, 1st Department of General Surgery, University of Milan, Milan, Italy
    Dis Colon Rectum 49:652-60. 2006
    ....
  81. ncbi Electrophysiologic evidence for an intersegmental reflex pathway between lumbar paraspinal tissues
    Yu Ming Kang
    Department of Biomedical Engineering, University of Iowa and the Iowa Spine Research Center, Iowa City, USA
    Spine (Phila Pa 1976) 27:E56-63. 2002
    ..A variety of approaches were used to demonstrate the reflex nature of both the nerve and the muscle response...
  82. ncbi Spastic reflexes triggered by ankle load release in human spinal cord injury
    Ming Wu
    Sensory Motor Performance Program, Rehabilitation Institute of Chicago, 345 E Superior Street, Room 1406, Chicago, IL 60611, USA
    J Neurophysiol 96:2941-50. 2006
    ..This knowledge may be especially helpful in the treatment of spasms and in identifying rehabilitation strategies for producing functional movements in human SCI...
  83. ncbi Paraspinal muscles and intervertebral dysfunction: part two
    Gary Fryer
    School of Health Science, Victoria University, Melbourne, Australia
    J Manipulative Physiol Ther 27:348-57. 2004
    ..but indirect evidence from experimental studies supports the plausibility of the concept of protective muscle spasm, although investigations of increased paraspinal electromyography (EMG) associated with low back pain suggests ..
  84. ncbi Botulinum toxin injection for treatment of spasmodic dysphonia: experience at Srinagarind Hospital
    Supaporn Srirompotong
    Department of Otolaryngology, Faculty of Medicine, Khon Kaen University 40002, Thailand
    J Med Assoc Thai 89:2077-80. 2006
    ..Spasmodic dysphonia (SD) is a focal dystonia and adductor SD is the most common form. The standard treatment for adductor SD is EMG-guided, transcutaneous injections of botulinum toxin into the thyroarytenoid muscle...
  85. ncbi Laterality and imbalance of muscle stiffness relate to personality
    Naoki Nakaya
    Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Behav Med 30:5-9. 2004
    ..The findings suggest that laterality and imbalance of muscle stiffness relate to personality...
  86. ncbi Improvement of severe trunk spasms by bilateral high-frequency stimulation of the motor thalamus in a patient with chorea-acanthocytosis
    Pierre Burbaud
    Service de Neurophysiologie Clinique, Centre Hospitalier Universitaire, Bordeaux, France
    Mov Disord 17:204-7. 2002
    ..We propose that HFS of the motor thalamus is a potential treatment for choreic or truncal dystonic symptoms whenever hypotonia is not the main feature of the syndrome...
  87. ncbi Multifidus spasms elicited by prolonged lumbar flexion
    M Williams
    Bioengineering Laboratory, Department of Orthopaedic Surgery, Louisiana State University Medical Center, New Orleans, Louisiana 70112, USA
    Spine (Phila Pa 1976) 25:2916-24. 2000
    ....
  88. ncbi Neuromuscular disorders associated with static lumbar flexion: a feline model
    M Solomonow
    Occupational Medicine Research Center and Bioengineering Laboratory, Department of Orthopaedic Surgery, Louisiana State University Medical Center, LA 70112, New Orleans, USA
    J Electromyogr Kinesiol 12:81-90. 2002
    ..Such disorder may take a long time to recover, in the order of days to weeks, depending on the level of creep developed in the tissues...
  89. ncbi Different approaches to dental management of self-inflicted oral trauma: oral shield, botulinum toxin type A neuromuscular block, and oral surgery
    Maria Teresa Botti Rodrigues Santos
    Division of Dentistry for Persons with Disabilities, School of Dentistry, Universidade Cruzeiro do Sul, Sao Paulo, Brazil
    Quintessence Int 39:e63-9. 2008
    ..To assess different approaches to the dental management of lip injuries caused by self-inflicted oral trauma in 7 patients...
  90. pmc Role of endogenous release of norepinephrine in muscle spasms after chronic spinal cord injury
    Michelle M Rank
    Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    J Neurophysiol 97:3166-80. 2007
    ....
  91. ncbi Progressive cervical kyphosis associated with botulinum toxin injection
    Kathleen A Hogan
    Department of Orthopedic Surgery, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 708, Charleston, SC 29425, USA
    South Med J 99:888-91. 2006
    ..In this article, we describe an elderly woman with rapidly progressive cervical kyphosis following an injection of botulinum toxin A into her neck extensor musculature...
  92. ncbi Complications and adverse reactions with the use of botulinum toxin
    Arnold William Klein
    Dis Mon 48:336-56. 2002
    ..Also included are recommendations as to how to avoid these very undesirable, yet common, problems...
  93. ncbi Management of vasospastic disorders with botulinum toxin A
    Allen L Van Beek
    Division of Plastic Surgery, Department of Cardiology, Minneapolis Heart Institute Foundation, Minneapolis, MN, USA
    Plast Reconstr Surg 119:217-26. 2007
    ..After digital artery sympathectomy, recurrence or persistence of vasospasm may compromise hand function and ultimately result in amputation of all or portions of both lower and upper extremities...
  94. ncbi [Physical medicine in the diagnosis and treatment of functional disorders of the spinal column]
    E Nemeth
    Sluzba za fizikalnu medicinu i rehabilitaciju, Zdravstveni centar Dr Gere Istvan, Senta
    Med Pregl 52:233-6. 1999
    ..Functional disorders are caused by direct or indirect injury (muscular spasm), inflammation, sudden movements etc...
  95. ncbi [Treatment of West syndrome]
    Ljerka Cvitanovic-Sojat
    Klinika za pedijatriju, Klinicka bolnica Sestre milosrdnice, Zagreb, Hrvatska
    Acta Med Croatica 59:19-29. 2005
    ..The aim of our study was to evaluate the efficacy of the control of infantile spasms using synthetic ACTH or vigabatrin in newly diagnosed cases and to correlate it with the underlyning causes, outcome and adverse effects...
  96. pmc Purinoceptors mediating relaxation and spasm in the rat gastric fundus
    M S Matharu
    Department of Physiological Sciences, Medical School, Manchester University
    Br J Pharmacol 106:395-403. 1992
    ..3. At resting tone, adenosine 5'-triphosphate (ATP) induced a small, phasic relaxation followed by a maintained spasm. When tone was raised by carbachol, ATP induced a larger relaxation followed by a smaller spasm...
  97. ncbi Vigabatrin: 2008 update
    L James Willmore
    Department of Neurology and Psychiatry, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, USA
    Epilepsia 50:163-73. 2009
    ..Response can be rapid with spasm cessation following approximately 2 weeks of therapy...
  98. ncbi Complications of posterior cranial fossa surgery--an institutional experience of 500 patients
    Arvind Dubey
    Department of Neurosurgery, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA
    Surg Neurol 72:369-75. 2009
    ..The purposes of this retrospective study are to draw attention to the potential complications associated with posterior fossa surgery and to critically review the predisposing factors that might influence the complication rate...
  99. ncbi Nitroglycerin is preferable to diltiazem for prevention of coronary bypass conduit spasm
    O M Shapira
    Department of Cardiothoracic Surgery, Boston University School of Medicine, Massachusetts, USA
    Ann Thorac Surg 70:883-8; discussion 888-9. 2000
    Diltiazem is widely used to prevent radial artery spasm after coronary bypass grafting (CABG). However, recent in vitro and in vivo studies have shown that nitroglycerin is a superior conduit vasodilator compared to diltiazem...
  100. pmc Tachykinin NK1 and NK2 receptor antagonists and atropine-resistant ascending excitatory reflex to the circular muscle of the guinea-pig ileum
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 112:161-8. 1994
    ..1 microM) resistant AER elicited by balloon distension averaged about 40-50% and 70-90% of maximal circular spasm to 80 mM KCl, respectively...
  101. ncbi Consumption of vitamin E in coronary circulation in patients with variant angina
    K Miwa
    Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan
    Cardiovasc Res 41:291-8. 1999
    The plasma status of vitamin E has been suggested to be linked to the activity of coronary artery spasm. This study was designed to determine whether vitamin E is actually consumed in the coronary circulation in patients with active ..

Research Grants62

  1. Mechanism of Bladder Overactivity in Pelvic Ischemia
    Kazem M Azadzoi; Fiscal Year: 2013
    ..Ischemia is one of the leading causes of smooth muscle spasm in the stomach, intestine, uterus, and bronchioles...
  2. Surgical Revascularization's Impact on Mitochondria in Hibernating Myocardium
    ROSEMARY FRANCES KELLY; Fiscal Year: 2013
    ..warning attacks, called angina, indicate that the heart is transiently stressed by increased work load demands, by spasm or fluctuating thrombosis in one of the arteries prior to its complete closure...
  3. Role of P450 Eicosanoids in Delayed Microvascular Spasm Following Subarachnoid He
    DOMINIC AARON SILER; Fiscal Year: 2013
    ..A recently documented phenomenon that correlates with delayed neurological deficit is delayed microvascular spasm (dMVS). Until now, the technology available to document dMVS has only been able to do so at very low resolution...
  4. Nitrergic Neuro-smooth Muscle Transmission in the Gut
    Raj K Goyal; Fiscal Year: 2013
    ..also implicated in diabetic gastroparesis and functional disorders of the gut such as irritable bowel syndrome and spasm of biliary and pancreatic sphincters. Nitric oxide is uniquely different from other classical neurotransmitters...
  5. Biomarkers of Vasospasm and Outcome following Subarachnoid Hemorrhage
    Sherry Hsiang Yi Chou; Fiscal Year: 2013
    ..of matrix metalloproteinases (MMPs) which can cleave endothelin-1 into fragments that can subsequently cause spasm of cerebral arteries...
  6. Regulatory Effects of Arx Polyalanine Tract Expansion in Murine Brain Development
    MacLean Pancoast; Fiscal Year: 2010
    ..One malignant form of epilepsy that accounts for approximately 15% of pediatric epilepsy is known as Infantile Spasm (IS)...
  7. Genesis of Esophageal Pain: Longitudinal Muscle Spasm and Wall Ischemia
    Ravinder K Mittal; Fiscal Year: 2013
    ..Esophagus is suspected to be the cause of pain in these patients. Gastro- esophageal reflux and esophageal spasm are 2 possible major causes of esophageal pain...
  8. Massage Therapy In Eccentric Exercise Induced Muscle Weakness And Inflammation
    THOMAS MICHAEL BEST; Fiscal Year: 2012
    ..and stiffness, faster healing of strained muscles and sprained ligaments, reduced muscle pain, swelling, and spasm, greater range of motion, and even enhanced athletic performance...
  9. Heterologous expression of an invertebrate sodium channel for neuronal activation
    ADAM RORY MCQUISTON; Fiscal Year: 2010
    ..Because inhibitory interneurons have roles in CNS diseases such as epilepsy, anxiety, schizophrenia and spasm, information obtained from these studies will be relevant to understanding how inhibitory interneuron dysfunction ..
  10. CORONARY STENOSIS, VASOMOTION AND THROMBUS FORMATION
    WILLIAM SANTAMORE; Fiscal Year: 1990
    Recent clinical observations on coronary artery spasm have generated renewed interest that vasomotion might be involved in the etiology of angina pectoris and myocardial infarction...
  11. ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDER
    Adil Bharucha; Fiscal Year: 2002
    ..Current pathophysiological paradigms focus on spasm of the puburectalis and external sphincters in OD, and anal sphincter trauma (usually obstetric) or pudendal ..
  12. BOTULINUM NEUROTOXIN: MECHANISM OF TOXICITY
    BIBHUTI DASGUPTA; Fiscal Year: 1991
    ..g. blepharospasm, hemifacial spasm, and strabismus in human patients...
  13. Altered balance of excitation and inhibition in a model of Infantile Spasm Epilep
    Yasmin Escobedo-Lozoya; Fiscal Year: 2013
    ..abstract_text> ..
  14. CHEMOMYECTOMY FOR EYELID SPASMS
    Linda McLoon; Fiscal Year: 1999
    Blepharospasm, hemifacial spasm and other diseases involving forceful, uncontrolled muscle spasms of the face and neck are extremely debilitating conditions that result in functional blindness, often causing affected persons to withdraw ..
  15. STUDIES OF THE PATHOPHYSIOLOGY OF HEMIFACIAL SPASM
    Aage Moller; Fiscal Year: 1990
    Classical hemifacial spasm (HFS) is in the majority of cases caused by cross-compression of the facial nerve near its entrance to the brainstem by a blood vessel, but its pathophysiology is largely unknown...
  16. MECHANISM AND THERAPY OF CEREBROVASCULAR SPASM
    Thomas Duff; Fiscal Year: 1992
    ..Hypothesis V will be investigated by quantitating angiographic changes following intra- arterial administration of albumin to animals previously subjected to subarachnoid hemorrhage...
  17. Neuromotor Modeling of Adductor Spasmodic Dysphonia
    Rick Roark; Fiscal Year: 2009
    ..We will achieve this goal by identifying specific motoneuron firing patterns that occur during vocal spasm by applying recently-developed multidimensional electromyographic technologies to laryngeal muscles...
  18. ROLE OF INTERNEURONAL CIRCUITS IN HUMAN SPINAL CORD INJU
    BRIAN SCHMIT; Fiscal Year: 2004
    ..flexion withdrawal reflex, which Is exaggerated in SCI, and the emergence of a novel reflex response, the extensor spasm. Knowledge of the afferent pathways and interneuronal systems responsible for flexor spasms is based on this ..
  19. TRYPANOSOMA CRUZI: PATHOGENESIS OF INFECTION
    Herbert Tanowitz; Fiscal Year: 2000
    ..endothelium modulates vessel tone by increasing the synthesis of the vasoactive peptide, ET-1 causing vascular spasm and myocardial ischemia. The MAPK cascades regulate AP-1 activation resulting in ET-1 expression...
  20. PATHOBIOLOGICAL DETERMINANTS OF ATHEROSCLEROSIS IN YOUTH
    Renu Virmani; Fiscal Year: 1990
    ..ii) The role of biogenic amines in the formation and progression of atherosclerotic plaques. Coronary artery spasm has been suggested as a possible mechanism of endothelial injury which in the setting of the well established risk ..
  21. HEAT SHOCK PROTEINS AND VASOSPASM
    Colleen Brophy; Fiscal Year: 2005
    DESCRIPTION (Verbatim from Applicant's Abstract): Vasospasm contributes to vein graft spasm during vascular reconstructive surgery, non-occlusive mesenteric ischemia' Raynaud's syndrome, and cerebral ischemia after subarachnoid ..
  22. TRYPANOSOMA CRUZI: PATHOGENESIS OF INFECTION
    Herbert Tanowitz; Fiscal Year: 2005
    ..endothelium modulates vessel tone by increasing the synthesis of the vasoactive peptide, ET- I causing vascular spasm and myocardial ischemia. The NIAPK cascades regulate AP-1 activation resulting in ET-1 expression...
  23. ORAL-FACIAL SINGLE SENSORY AXON TERMINATIONS
    RANDALL SHULTS; Fiscal Year: 1990
    ..Clinical symptoms such as myofacial pain and muscle spasm of splinting often appear to incorporate both sensory and motor elements during the course of the disease process...
  24. PROTEIN KINASE C AND SMOOTH MUSCLE CONTRACTION
    HOWARD RASMUSSEN; Fiscal Year: 1993
    ..insights into the cellular and molecular basis of smooth muscle contraction which could point the way to a better understanding of the altered states of smooth muscle contraction seen in asthma, hypertension and cerebral vascular spasm.
  25. MUSCARINIC CONTROL OF GASTROINTESTINAL SMOOTH MUSCLE
    Jeffrey Conklin; Fiscal Year: 1991
    ..Alterations in these control mechanisms may be responsible for such illnesses as diffuse esophageal spasm or idiopathic intestinal pseudoobstruction...
  26. CENTRAL CORONARY FLOW REGULATION
    David Gutterman; Fiscal Year: 1990
    ..The results of these experiments will have important clinical ramifications since the sympathetic nervous system has been implicated as an important etiologic factor in coronary artery spasm, angina pectoris, and myocardial infarction.
  27. FLOW-INDUCED NEAR-WALL EXCESS OF PLATELETS
    Eugene Eckstein; Fiscal Year: 1993
    ..Such experiments simulate events in vascular spasm and permit modelling of platelet transport in accelerating and decelerating flow fields.
  28. Geriatric Incontinence: The Brain-Bladder Connection
    Derek Griffiths; Fiscal Year: 2006
    ..The most common type, urge incontinence, is due to bladder spasm (detrusor overactivity) and represents a failure of bladder control...
  29. HERPES REACTIVATIONS AFTER CRANIAL NERVE SURGERY
    John Armstrong; Fiscal Year: 1980
    ..The patients, and others including those undergoing VIIth nerve surgery for hemi-facial spasm will be followed clinically, virologically and immunologically...
  30. PATTERN SIGNATURES OF LARYNGEAL MYOELECTRIC SIGNALS
    Rick Roark; Fiscal Year: 2000
    ..early detection of diseases that manifest with vocal symptoms, such as Parkinson's and ALS, and for the pre-surgical testing of the propensity for potentially life- threatening laryngeal tonic closure (spasm) due to intubation trauma.
  31. MAXIK CHANNELS IN AGING CORONARY SMOOTH MUSCLE
    LIGIA TORO DE STEFANI; Fiscal Year: 2003
    ..This study will aid our understanding of age-related changes of coronary vasoreactivity, and possibly in the design of clinical treatments that reduce coronary spasm and heart dysfunction.
  32. CELLULAR ALTERATION OF VASCULAR INJURY
    LOUIS BIRINYI; Fiscal Year: 1992
    ..ANP) from EC's relining endarterectomized vessels may improve patency either by directly decreasing vessel spasm after injury, or by dilating distal small caliber resistance vessels and increasing blood flow across an ..
  33. Calcium desensitization in Smooth Muscle
    Timothy Haystead; Fiscal Year: 2009
    ..underlie the molecular basis of several human diseases that involve smooth muscle including hypertension, bronco spasm, sexual dysfunction, gastrointestinal disorders and glaucoma...
  34. Sulfonylurea KATP channels in vascular spasm
    Elizabeth McNally; Fiscal Year: 2009
    ..Additionally, SUR2 mutant mice display episodic coronary artery vascular spasm that can be visualized by electrocardiographic monitoring and by direct visualization of coronary arteries...
  35. Development of a vasoactive biogel
    Colleen Brophy; Fiscal Year: 2002
    ..The purpose of this proposal is to develop a peptide based therapeutic agent for the prevention of vein graft spasm. The hypotheses of this investigation is that synthetic peptide analogues of the phosphoprotein that mediates ..
  36. KININ RECEPTORS--MOLECULAR PROPERTIES AND REGULATION
    FREDRIK LEEB LUNDBERG; Fiscal Year: 2002
    ..The physiological responses to kinins include vasodilatation, smooth muscle spasm, edema, hyperalgesia, pain, modulation of hormone and cytokine release, increased epithelial transport, and cell ..
  37. eNOS Polymorphisms, Aging and Platelet Function
    Jane Freedman; Fiscal Year: 2005
    ..Select polymorphic variants have been associated with coronary spasm and myocardial infarction, however, the role of eNOS mutations in platelet-derived NO release or its contribution ..
  38. CARDIOVASCULAR EFFECTS AND TOXICITIES OF COCAINE
    Koonlawee Nademanee; Fiscal Year: 1991
    ..cocaine concentration that will compromise cardiac function and/or precipitate coronary vasoconstriction and/or spasm? 2) At what dose will the direct cardiovascular effects of cocaine become manifest? At what dose will cocaine ..
  39. POSTNATAL RESPIRATORY DEVELOPMENT AS RELATED TO SIDS
    Clarence Sasaki; Fiscal Year: 1980
    ..organization of the laryngeal adductor reflexes with respect to a) protective glottic closure, and b) laryngeal spasm; 2) select, by means of such accumulated data, the animal model most analogous to the human being in its central ..
  40. A Device for Quantifying Spasticity
    B Parker; Fiscal Year: 2001
    ..physical activity and participation in society, motor incoordination, muscle tightness and bony deformities, and spasm- related pain...
  41. ROLE OF PUBORECTALIS MUSCLE IN FECAL CONTINENCE
    RAVINDER MITTAL; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  42. PHARYNGEAL RECEPTORS AND REFLUX DISEASE
    RAVINDER MITTAL; Fiscal Year: 2001
    ..Effects of atropine on the frequency of TLESR and GER in patients with reflux esophagitis. ..
  43. Anatomic and Mechanical Variables of the EGJ in GERD
    John Pandolfino; Fiscal Year: 2006
    ..These changes will improve diagnostic accuracy of pH monitoring and also help determine the relationship between anatomical and mechanical variants and acid reflux. ..
  44. Research Symposium on Functional Abdoninal Pain in Children
    Samuel Nurko; Fiscal Year: 2007
    ..7. To educate the NASPGHAN membership on the state of the art of functional abdominal pain and IBS in children. [unreadable] [unreadable] [unreadable]..
  45. Aging, Exercise and Endothelin-1 Vasoconstrictor Tone
    CHRISTOPHER DESOUZA; Fiscal Year: 2007
    ....
  46. Obesity/Insulin Resistance and Endothelial t-PA Release
    CHRISTOPHER DESOUZA; Fiscal Year: 2003
    ..abstract_text> ..
  47. ROLE OF STRETCH-INDUCED COX-2 IN BLADDER CONTRACTILITY
    John Park; Fiscal Year: 2003
    ..Therefore, characterizing the biological role of PG synthetic pathways via COX-2 gene activation in bladder should lead to novel insights in the overall management of painful bladder syndromes. ..
  48. LOW BACK PAIN IN CYCLIC AND PROLONGED ACTIVITIES
    Moshe Solomonow; Fiscal Year: 2002
    ....
  49. Endothelial Abnormalities in Obesity/Insulin Resistance
    CHRISTOPHER DESOUZA; Fiscal Year: 2005
    ..abstract_text> ..
  50. Osteopuncture for OA-Associated Knee Pain & Disability
    Debra Weiner; Fiscal Year: 2005
    ..In addition, mechanisms of action will be explored, and the impact of osteopuncture on health care costs determined. ..
  51. POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAIN
    William Armstead; Fiscal Year: 2005
    ..These studies may lead to therapies for brain injured children. ..
  52. Clinical Trial Development in Chronic Pelvic Pain Syndr*
    Daniel Shoskes; Fiscal Year: 2007
    ..There is evidence for infection, inflammation and neuromuscular spasm as the underlying cause in different patients despite identical clinical presentation...
  53. Limbic & Motor System Interaction in Laryngeal Function
    Douglas Van Daele; Fiscal Year: 2008
    ..It will promote a better understanding of how speech is acquired and generated at the cortical level, of voice disorders such as spasmodic dysphonia, of the focal dystonias, and of speech recovery after brain injury. ..
  54. Leupeptin in a Canine Model of Duchenne Muscular Dystrophy
    MARTIN CHILDERS; Fiscal Year: 2006
    ..Specific Aim #4b: Compare lean body muscle mass and calpain activity between leupeptin and placebo-treated GRMD dogs. ..
  55. CARDIOVASCULAR SURGERY RESEARCH TRAINING GRANT
    Frank Sellke; Fiscal Year: 2008
    ..It is anticipated that this program in cardiovascular surgery research training will help the specialty continue to train outstanding academic surgeons in times of financial, clinical, and educational uncertainty. ..