Genomes and Genes
Summary: Abnormal increase in skeletal or smooth muscle tone. Skeletal muscle hypertonicity may be associated with PYRAMIDAL TRACT lesions or BASAL GANGLIA DISEASES.
Publications196 found, 100 shown here
- Urinary dysfunction and autonomic control in amyloid neuropathyTakashi Ito
Neurology Dept, Chiba University, 1 8 1 Inohana Chuo ku, Chiba 260 8670, Japan
Clin Auton Res 16:66-71. 2006..The underlying mechanisms of urinary dysfunction seem to involve postganglionic cholinergic and afferent somatic nerves...
- Pathophysiological mechanisms of dominant and recessive GLRA1 mutations in hyperekplexiaSeo Kyung Chung
Institute of Life Science, School of Medicine, Swansea University, Swansea, United Kingdom
J Neurosci 30:9612-20. 2010..This study also reports the first hyperekplexia mutation associated with a GlyR leak conductance, suggesting tonic channel opening as a new mechanism in neuronal ligand-gated ion channels...
- The genetics of hyperekplexia: more than startle!Robert J Harvey
Department of Pharmacology, The School of Pharmacy, London WC1N 1AX, UK
Trends Genet 24:439-47. 2008....
- Procedure- and device-related complications of intrathecal baclofen administration for management of adult muscle hypertonia: a reviewIvana Stetkarova
Na Homolce Hospital, Prague, Czech Republic
Neurorehabil Neural Repair 24:609-19. 2010Intrathecal baclofen (ITB) effectively reduces muscle hypertonia; however, associated complications influence its utility and acceptance.
- Spasticity or reversible muscle hypertonia?Abdel Magid O Bakheit
Moseley Hall Hospital, Birmingham B13 6JA, UK
J Rehabil Med 43:556-7. 2011..In this report we propose an alternative terminology and explain the reasons for doing so...
- Paratonia: a Delphi procedure for consensus definitionJohannes S M Hobbelen
Physiotherapy Research Vitalis Zorggroep Eindhoven, Vlasmeersestraat 5, 5261 TA Vught, The Netherlands
J Geriatr Phys Ther 29:50-6. 2006..For this reason, we initiated a Delphi procedure with known experts in the field to establish an operational consensus definition of paratonia...
- Lower urinary tract function in dementia of Lewy body typeR Sakakibara
Neurology Department, Chiba University, Chuo Ku, Chiba 260 8670, Japan
J Neurol Neurosurg Psychiatry 76:729-32. 2005..Lower urinary tract (LUT) function in DLB has not been fully delineated. We investigated LUT function in DLB by evaluating clinical and urodynamic data...
- Decreased sensory receptors P2X3 and TRPV1 in suburothelial nerve fibers following intradetrusor injections of botulinum toxin for human detrusor overactivityA Apostolidis
Peripheral Neuropathy Unit, Hammersmith Hospital, Imperial College London, United Kingdom
J Urol 174:977-82; discussion 982-3. 2005..We investigated a possible effect of BoNT/A on human bladder afferent mechanisms by studying the sensory receptors P2X3 and TRPV1 in biopsies from patients with neurogenic or idiopathic DO...
- Success of repeat detrusor injections of botulinum a toxin in patients with severe neurogenic detrusor overactivity and incontinenceJoachim Grosse
Department of Urology, Berufsgenossenschaftliche Unfallklinik Murnau, Murnau, Germany
Eur Urol 47:653-9. 2005..When the patients develop botulinum resistance, subsequent injections might be less effective. Repeat injections in patients with severe neurogenic detrusor overactivity and incontinence were studied...
- Urgency of micturition and detrusor contractility in men with prostatic obstruction and overactive bladdersA Cucchi
Divisione di Urologia, Policlinico San Matteo, Pavia, Italy
Neurourol Urodyn 24:202-6. 2005..In men with prostatic obstruction and detrusor overactivity (DO), to ascertain whether urgency of micturition affects bladder contractility...
- Botulinum toxin: a new dimension in the treatment of lower urinary tract dysfunctionArun Sahai
Urology 65:211. 2005
- [Urinary incontinence in the woman--pathophysiology and diagnosis]G Schär
Frauenklinik, Kantonsspital Aarau
Ther Umsch 60:249-56. 2003..An urodynamic evaluation together with perineal ultrasound and cystoscopy is performed in patients with complex or recurrent urinary incontinence after surgery or with micturition disorders...
- Botulinum toxin A for treatment of neurogenic detrusor overactivity and incontinence in patients with spinal cord lesionsPer Bagi
Clinics for Urology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
Scand J Urol Nephrol 38:495-8. 2004..To evaluate the efficacy of intravesical botulinum toxin A (BTA) in the treatment of severe neurogenic detrusor overactivity (NDO) with incontinence in patients with spinal cord lesions (SCLs)...
- [Urodynamic findings in patients with infantile cerebral palsy]S Bross
Urologische Universitätsklinik, Klinikum Mannheim gGmbH, Mannheim
Aktuelle Urol 35:54-7. 2004..Aim of study was to evaluate the urodynamic findings in patients with infantile cerebral palsy...
- Treatment of neurogenic detrusor overactivity in spinal cord injured patients by conditional electrical stimulationJ Hansen
Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
J Urol 173:2035-9. 2005..The feasibility of automatic event driven electrical stimulation of the dorsal penile/clitoral nerve in the treatment of neurogenic detrusor overactivity (NDO) was evaluated in individuals with spinal cord injury...
- Urgency: the cornerstone symptom of overactive bladderAlan J Wein
J Urol 173:2054. 2005
- Effect of botulinum toxin type A on cerebral palsy with upper limb spasticityTsui Fen Yang
Department of Physical Therapy, School of Medicine, National Yang Ming University, Taipei, Taiwan
Am J Phys Med Rehabil 82:284-9. 2003..The objective of this study was to investigate the effects of botulinum toxin type A injections in reducing upper limb muscular spasticity and in improving motor function in children with cerebral palsy...
- Home uroflowmetry for the evaluation of boys with urinary incontinenceStephen Shei Den Yang
Department of Urology, En Chu Kong Hospital, School of Medicine, Taipei Medical University, Taiwan
J Urol 169:1505-7. 2003..We recorded uroflowmetry at home in boys with urinary incontinence and correlated the results with videourodynamics...
- [Efficacy of botulinum toxin A for the treatment of detrusor hyperreflexia]P Denys
Service de Medecine Physique et de Readaptation, Hopital Raymond Poincare, AP HP, Faculte de Medecine Paris Ile de France Ouest, 104, Boulevard Raymond Poincare, 92380 Garches, France
Ann Readapt Med Phys 46:326-8. 2003..To determinate the efficacy of botulinum toxin to treat refractory urinary incontinence due to bladder hyperreflexia...
- Bladder neck cinch for pediatric neurogenic outlet deficiencyCharles E Bugg
Division of Urology, University of Alabama at Birmingham and Childre s Hospital, Alabama 35233, USA
J Urol 170:1501-3; discussion 1503-4. 2003..We evaluated the effectiveness of a rectus fascia bladder neck cinch which applies circumferential pressure around the bladder neck and elevation as a means of increasing outlet resistance...
- [Minimally invasive, safe treatment of the neurogenic bladder with botulinum-A-toxin in children with myelomeningocele]L Lusuardi
Department für Kinderurologie, Krankenhaus der Barmherzigen Schwestern, Linz A
Aktuelle Urol 35:49-53. 2004..The efficacy and durability of botulinum-A toxin in the treatment of detrusor hyperreflexia in myelomeningocele (MMC) children was evaluated prospectively...
- Preliminary observations of a synergistic bladder-sphincter relationship following spinal cord injury in a quadruped animalJames S Walter
Research Service, Department of Veterans Affairs, Edward Hines Jr Hospital, Hines, Illinois 60141, USA
J Spinal Cord Med 26:372-9. 2003..The objective of this study was to determine whether sensory input from the bladder produced synergistic or dyssynergic pelvic floor reflexes following SCI in an animal model...
- [Biofeedback for urinary bladder dysfunctions in childhood. Indications, practice and the results of therapy]J Hoang-Böhm
Urologische Klinik, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg
Urologe A 43:813-9. 2004..After effective therapy, associated urinary tract infections and vesicoureterorenal reflux may disappear...
- Does posture affect cystometric parameters and diagnoses?A S Arunkalaivanan
Department of Urodynamics and Urogynaecology, City Hospital, Dudley Road, Birmingham, B18 7QH, UK
Int Urogynecol J Pelvic Floor Dysfunct 15:422-4; discussion 424. 2004..Therefore, we recommend that sitting posture is preferred over lying position for performing cystometry...
- [Bamberg Discussions 2003. Diagnosis and therapy of urinary incontinence in diabetic patients]H Madersbacher
Krankenpfl J 41:176-7. 2003
- Preliminary communication: urodynamic assessment of donepezil hydrochloride in patients with Alzheimer's diseaseRyuji Sakakibara
Department of Neurology, Chiba University, Chiba, Japan
Neurourol Urodyn 24:273-5. 2005..Donepezil hydrochloride, a central cholinergic drug, is widely used for improving cognitive decline in Alzheimer's disease (AD). We investigated whether donepezil might affect the lower urinary tract (LUT) function in AD...
- Distinguishing neurogenic from non-neurogenic detrusor overactivity: a urodynamic assessment of lower urinary tract symptoms in patients with and without Parkinson's diseaseGina A Defreitas
Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9110, USA
Urology 62:651-5. 2003..To examine the urodynamic (UDS) attributes of detrusor overactivity (DO) in patients with Parkinson's disease in comparison to DO in men without neurologic disease, in whom DO is presumably outlet obstruction induced...
- Trospium chloride for the treatment of detrusor instability in childrenP Lopez Pereira
Department of Pediatric Urology, University Hospital La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain
J Urol 170:1978-81. 2003..We assessed the efficacy and most appropriate dosage of trospium chloride (TCl) for managing bladder instability in children as compared with a placebo...
- Resiniferatoxin for detrusor instability refractory to anticholinergicsPaulo C R Palma
Division of Urology, State University of Campinas, UNICAMP, Campinas, Sao Paulo, Brazil
Int Braz J Urol 30:53-8. 2004..We have evaluated the clinical and urodynamic effects of intravesical instillation of resiniferatoxin in patients with idiopathic detrusor instability refractory to anticholinergics...
- Can neurologic examination predict type of detrusor sphincter-dyssynergia in patients with spinal cord injury?Brigitte Schurch
Department of Neuro Urology, Swiss Paraplegic Center, Balgrist University Hospital, Zurich, Switzerland
Urology 65:243-6. 2005....
- [Pathophysiology of urge, stress, and mixed incontinence]S Schumacher
Department of Urology, Zayed Military Hospital, Abu Dhabi, V A E
Urologe A 44:239-43. 2005..Stress and urge incontinence can occur in combination and then be defined as mixed incontinence...
- Autoaugmentation by detrusor myotomy: its lack of effectiveness in the management of congenital neuropathic bladderAndrew E MacNeily
Division of Pediatric Urology, British Columbia Children s Hospital, University of British Columbia, Vancouver, Canada
J Urol 170:1643-6; discussion 1646. 2003..We present our long-term results in 17 patients with myelomeningocele undergoing autoaugmentation by vesicomyotomy...
- Polyethylene glycol 3350 for constipation in children with dysfunctional eliminationBrad A Erickson
Division of Pediatric Urology, Children s Hospital of Iowa, Iowa City, USA
J Urol 170:1518-20. 2003..Polyethylene glycol 3350 (Miralax, Braintree Laboratories, Braintree, Massachusetts) is a nonaddictive, tasteless powder that can be mixed with any liquid for treatment of constipation...
- Urodynamic effect of intravesical resiniferatoxin in patients with neurogenic detrusor overactivity of spinal origin: results of a double-blind randomized placebo-controlled trialCarlos Silva
Department of Urology, Hospital S Joao, 4200 319 Porto, Portugal
Eur Urol 48:650-5. 2005..To access by a placebo-controlled randomized clinical trial the effect of intravesical resiniferatoxin on the urodynamic parameters of patients with neurogenic detrusor overactivity (NDO) of spinal origin...
- [Management of urinary incontinence in the aging man]M Staehler
Urologische Klinik und Poliklinik, Klinikum Grosshadern, LMU Munchen
MMW Fortschr Med 147:29-32. 2005..Moreover, the problem can be successfully controlled in the majority of the patients through very specific drug and surgical therapeutic concepts...
- Urodynamic study in the neurogenic bladder dysfunction caused by intervertebral disk herniaDexin Dong
Department of Urology, Qilu Hospital of Shandong University, Jinan, China
Neurourol Urodyn 25:446-50. 2006..To discuss the clinical significance of urodynamic studies in neurogenic bladder dysfunction caused by intervertebral disk hernia...
- Safety and efficacy of tramadol in the treatment of idiopathic detrusor overactivity: a double-blind, placebo-controlled, randomized studyM R Safarinejad
Urology Nephrology Research Centre, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
Br J Clin Pharmacol 61:456-63. 2006..To evaluate the efficacy and safety of tramadol in patients with idiopathic detrusor overactivity (IDO)...
- Urodynamic distinctions between idiopathic detrusor overactivity and detrusor overactivity secondary to multiple sclerosisGary E Lemack
Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9110, USA
Urology 67:960-4. 2006....
- Trospium chloride in patients with neurogenic detrusor overactivity: is dose titration of benefit to the patients?M Menarini
Spinal Cord Unit, Montecatone Rehabilitation Institute, Montecatone di Imola
Int J Clin Pharmacol Ther 44:623-32. 2006....
- Sacral bladder denervation for treatment of detrusor hyperreflexia and autonomic dysreflexiaM Hohenfellner
Department of Urology, Johannes Gutenberg-University, Mainz, Germany
Urology 58:28-32. 2001..It is only moderately invasive in nature, requires neither sophisticated nor expensive medical equipment, and is an attractive alternative to urinary diversion using intestinal segments...
- How many uncomplicated male and female overactive bladder patients reveal detrusor overactivity during urodynamic study?Noritoshi Sekido
Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
Int J Urol 13:1276-9. 2006..We retrospectively evaluated the incidence of detrusor overactivity (DO) in uncomplicated overactive bladder syndrome (OAB) patients...
- Involuntary detrusor contractions: correlation of urodynamic data to clinical categoriesL J Romanzi
Weill Medical College, Cornell University, New York, New York, USA
Neurourol Urodyn 20:249-57. 2001..However, the ability to abort IDC and stop incontinent flow may have prognostic implications, especially for the response to behavior modification, biofeedback, and pelvic floor exercise...
- Predictive value of initial urodynamic pattern on urinary continence in patients with myelomeningoceleThomas M Kessler
Neuro urology unit, Department of Neurology, University Hospital Innsbruck, Innsbruck, Austria
Neurourol Urodyn 25:361-7. 2006..To investigate whether the initial urodynamic pattern may predict urinary continence and the need for adjunctive incontinence surgery in patients with myelomeningocele...
- Neurogenic bladder treatment by doubling the recommended antimuscarinic dosageM Horstmann
Department of Urology, University of Tubingen, Tubingen, Germany
Neurourol Urodyn 25:441-5. 2006..All patients were suffering from neurogenic detrusor overactivity incontinence. Tolerability and success were evaluated in the present study...
- [Injections of botulinum toxin a into the detrusor vesicae for treatment of refractory detrusor hyperactivity in non-neurological patients]F Neugart
Klinikum Offenburg, Klinik für Urologie und Kinderurologie, Offenburg
Aktuelle Urol 37:212-7. 2006..g., for treatment of detrusor hyperreflexia in neurogenic bladders. Several groups have evaluated the efficacy of the substance in patients with an anticholinergic-refractory detrusor hyperactivity without neurological disease...
- Efficacy of botulinum-a toxin in children with detrusor hyperreflexia due to myelomeningocele: preliminary resultsH Schulte-Baukloh
Department of Urology, St Hedwig Hospital, Teaching Hospital of University Hospital Charité, Berlin, Germany
Urology 59:325-7; discussion 327-8. 2002..With the intent of avoiding surgery, we investigated the effect of botulinum-A toxin for treating detrusor hyperreflexia in this group of patients...
- Efficacy and safety of transdermal oxybutynin in patients with urge and mixed urinary incontinenceRoger R Dmochowski
Urology Associates of North Texas, Fort Worth, Texas, USA
J Urol 168:580-6. 2002..We evaluated the efficacy and safety of an oxybutynin transdermal delivery system (TDS) in a general population of patients with overactive bladder and urge or mixed urinary incontinence...
- A comparison between the response of patients with idiopathic detrusor overactivity and neurogenic detrusor overactivity to the first intradetrusor injection of botulinum-A toxinRoshni Popat
Department of Uro Neurology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals, United Kingdom
J Urol 174:984-9. 2005..The purpose of this study was to investigate whether comparable efficacy could be displayed in the response of patients with IDO to those with NDO...
- [When is a urodynamic investigation indicated for overactive bladder?]S Schumacher
Urologische Klinik und Poliklinik der Rheinischen Friedrich Wilhelms Universität Bonn
Urologe A 42:801-6. 2003..Diagnostic evaluation of geriatric patients with overactive bladder can usually be accomplished with a basic assessment while invasive procedures should be the exception...
- Urodynamic evaluation of the human bladder response to an increase in outlet resistanceJason D Engel
Department of Urology, Northwestern University School of Medicine, Chicago, Illinois, USA
Neurourol Urodyn 21:524-8. 2002..We prospectively evaluated the response of the human bladder to a chronic increase in urethral resistance according to the indices of pressure, volume flow rate, total (external) bladder work, and maximum and average detrusor power...
- Urgency, botulinum toxin and how botulinum toxin can help urgencyMichael B Chancellor
J Urol 174:818. 2005
- [Pudendal nerve stimulation therapy of the overactive bladder -- an alternative to sacral neuromodulation?]C Seif
Universitatsklinikum Schleswig Holstein, Campus Kiel, Klinik für Urologie und Kinderurologie
Aktuelle Urol 36:234-8. 2005..The BION-stimulator, which only measures 2.8 x 0.3 cm, is designed for pudendal nerve stimulation. Its implantation technique as well as the first clinical results are presented and discussed...
- [Subjective patient satisfaction after injection of botulinum-a toxin in detrusor overactivity]H Schulte-Baukloh
Urologische Abteilung, St Hedwig Kliniken GmbH, Akademisches Lehrkrankenhaus der Universitätsmedizin Berlin, Campus Chárite, Berlin
Aktuelle Urol 36:230-3. 2005..We were particularly interested in patient satisfaction with this therapy...
- Comparative study of pressure-flow parametersLars M Eri
Department of Urology, Ullevaal University Hospital, Oslo, Norway
Neurourol Urodyn 21:186-93. 2002..In assessment of a large decrease in urethral resistance, such as after TURp, resistance parameters that are based on maximum flow rate as well as detrusor pressure are preferable...
- Spontaneous and experimental glycoprotein storage disease of goats induced by Ipomoea carnea subsp fistulosa (Convolvulaceae)A G Armien
Institut für Veterinär Pathologie, Justus Liebig Universitat Giessen, Giessen, Germany
Vet Pathol 44:170-84. 2007..ataxia, posterior paresis, proprioceptive deficits, abnormal posture, abnormal postural reaction, and muscle hypertonia were necropsied. I fistulosa was suspected to be the cause of the neurologic disease in all cases...
- Evidence for a significant role of a Gs-triggered mechanism unrelated to the activation of adenylyl cyclase in the cyclic AMP-independent relaxant response of guinea-pig tracheal smooth muscleYoshio Tanaka
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Miyama 2 2 1, Chiba 274 8510, Funabashi City, Japan
Naunyn Schmiedebergs Arch Pharmacol 368:437-41. 2003..This mechanism may account in part for the cyclic AMP-independent relaxant response of tracheal smooth muscle...
- GM1 gangliosidosis in adults: clinical and molecular analysis of 16 Japanese patientsK Yoshida
Department of Clinical Genetics, Tokyo Metropolitan Institute of Medical Science, Japan
Ann Neurol 31:328-32. 1992..Major clinical manifestations were gait and speech disturbances caused by persistent muscle hypertonia. Dystonic postures and movements, facial grimacing, and parkinsonian manifestations were commonly seen...
- [Focus on current research: improving the mobility of paraplegic patients]V Dietz
Schweizerisches Paraplegikerzentrum, Universitätsklinik Balgrist, Zurich
Schweiz Med Wochenschr 130:829-36. 2000..symptoms and clinical (physical) signs suggests that the exaggerated tendon tap reflexes are responsible for muscle hypertonia and the latter causes the movement disorder...
- The pharmacology of the internal anal sphincter and new treatments of ano-rectal disordersT A Cook
University Department of Pharmacology, John Radcliffe Hospital, Oxford, UK
Aliment Pharmacol Ther 15:887-98. 2001..Further understanding of the pharmacology of the internal anal sphincter may permit the development of new agents to selectively target the tissue with greater efficacy and fewer side-effects...
- Postural sway during single and repeated cold exposuresTiina M Mäkinen
Centre for Arctic Medicine, Thule Institute, University of Oulu, P O Box 5000, FIN 90014 University of Oulu, Oulu, Finland
Aviat Space Environ Med 76:947-53. 2005..Tissue cooling changes sensory and neuromuscular functions that are also involved in postural control. The purpose of the study was to determine how acute and repeated exposures to cold affect whole body postural control...
- Botulinum toxin B increases mouth opening in patients with spastic trismusU M Fietzek
Neurologisches Krankenhaus München, Center for Parkinson s disease and Movement Disorders, Parzivalplatz 4, D 80804 Munich, Germany
Eur J Neurol 16:1299-304. 2009..generalized spastic movement disorders of various aetiologies often involve the jaw muscles and lead to a spastic trismus with masseter muscle hypertonia. We report a placebo-controlled randomized study on patients with spastic trismus.
- [Age for sitting and walking in children born weighing less than 1,500 g and normal motor development at two years of age]C R Pallas Alonso
Servicio de Neonatologia, Hospital 12 de Octubre, Madrid
An Esp Pediatr 53:43-7. 2000....
- A novel recessive hyperekplexia allele GLRA1 (S231R): genotyping by MALDI-TOF mass spectrometry and functional characterisation as a determinant of cellular glycine receptor traffickingAndreas Humeny
Institut fur Biochemie, Emil Fischer Zentrum, Friedrich Alexander Universitat Erlangen Nurnberg, D91054 Erlangen, Germany
Eur J Hum Genet 10:188-96. 2002..STHE) is a hereditary neurological disorder characterised by an exaggerated startle response and infantile muscle hypertonia. Several autosomal dominant and recessive forms of the disorder have been associated with point mutations in ..
- Voluntary ankle flexor activity and adaptive coactivation gain is decreased by spasticity during subacute spinal cord injuryJ Gómez-Soriano
Grupo Función Sensitivomotora, Hospital Nacional de Paraplejicos, SESCAM, Finca La Peraleda s n, 45071 Toledo, Spain
Exp Neurol 224:507-16. 2010Although spasticity has been defined as an increase in velocity-dependent stretch reflexes and muscle hypertonia during passive movement, the measurement of flexor muscle paresis may better characterize the negative impact of this ..
- The glycinergic system in human startle disease: a genetic screening approachJeff S Davies
Institute of Life Science, School of Medicine, Swansea University Singleton Park, Swansea, UK
Front Mol Neurosci 3:8. 2010....
- Hereditary hyperekplexia caused by novel mutations of GLRA1 in Turkish familiesSandra L Gilbert
Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA
Mol Diagn 8:151-5. 2004..Genetic studies have linked mutations in the gene encoding glycine receptor alpha1 (GLRA1) with hereditary hyperekplexia...
- Progress in the understanding and treatment of chronic anal fissureK McCallion
Department of Surgery, Queen s University, Belfast, UK
Postgrad Med J 77:753-8. 2001..Temporary reduction in sphincter tone can be achieved on an outpatient basis by applying a topical nitric oxide donor (for example, glyceryl trinitrate) or injecting botulinum toxin into the anal sphincter...
- [Basic principles of non-respiratory physiotherapy for neuromuscular diseases]I Watzek
Neurologische Klinik der Friedrich Alexander Universität Erlangen Nürnberg
Pneumologie 62:S28-30. 2008..Loss of upper neurons leads to the development of spasticity and muscle hypertonia whereas muscular atrophy and weakness is a prominent feature of lower motor neuron loss...
- [Drug treatment for children with cerebral palsy]Hilla Ben-Pazi
Pediatric Movement Disorders, Department of Child Neurology, Stanford Medical Center, CA 94305 5235, USA
Harefuah 145:510-5, 550. 2006..This motor dysfunction is caused by several motor components such as weakness, lack of motor control and muscle hypertonia. Drug treatment, delineated in this review, mainly addresses the latter...
- A critical role for glycine transporters in hyperexcitability disordersRobert J Harvey
Department of Pharmacology, The School of Pharmacy London, UK
Front Mol Neurosci 1:1. 2008..These findings highlight the importance of these transporters in regulating the levels of synaptic glycine...
- Botulinum toxin in post-stroke patients: stiffness modifications and clinical implicationsGiacinta Miscio
Department of Neurology, Istituto Auxologico Italiano, IRCCS, Strada L Cadorna 90, 28824, Piancavallo Oggebbio VB, Italy
J Neurol 251:189-96. 2004..To objectively quantify stiffness and clinical changes in the upper limb of poststroke patients following botulinum toxin (BT) injection...
- The relation between Ashworth scale scores and the excitability of the alpha motor neurones in patients with post-stroke muscle spasticityA M O Bakheit
Peninsula Medical School and Plymouth Primary Care Trust, Plymouth, UK
J Neurol Neurosurg Psychiatry 74:646-8. 2003..The modified Ashworth scale (MAS) is the most widely used method for assessing muscle spasticity in clinical practice and research. However, the validity of this scale has been challenged...
- [New therapeutic methods for spasticity and dystonia in children with cerebral palsy require multidisciplinary team work. Comprehensive approach yields good results]Lena Westbom
Barnneurologiska sektionen, Barn och ungdomssjukhuset, Universitetssjukhuset i Lund
Lakartidningen 100:125-30. 2003..We have found that a common structured and standardized follow-up programme with early intervention against muscle hypertonia and imbalance can prevent hip luxation and contractures in children with CP.
- A missense mutation in the gene encoding the alpha 1 subunit of the inhibitory glycine receptor in the spasmodic mouseS G Ryan
Department of Pediatrics, University of Texas Health Science Center, San Antonio 78284
Nat Genet 7:131-5. 1994..We conclude that spd is a murine homologue of hyperekplexia and that mutations in GLRA1/Glra1 can produce syndromes with different inheritance patterns...
- Evidence for recessive as well as dominant forms of startle disease (hyperekplexia) caused by mutations in the alpha 1 subunit of the inhibitory glycine receptorM I Rees
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK
Hum Mol Genet 3:2175-9. 1994..This suggests that human startle disease can display recessive as well as dominant inheritance resulting from different mutations in GLRA 1...
- [Symptomatic approach to musculoskeletal dysfunction and chronic pelvic and perineal pain]J J Labat
Centre fédératif de pelvipérinéologie, Clinique Urologique, CHU de Nantes, 44093 Nantes, France
Prog Urol 20:982-9. 2010Clinical examination of a patient with chronic pelvic and perineal pain often demonstrates muscle hypertonia or muscle contracture sometimes associated with local tenderness or real muscle trigger points...
- Familial hyperekplexia and refractory status epilepticus: a new autosomal recessive syndromeTally Lerman-Sagie
Metabolic Neuro Genetic Clinic, Wolfson Medical Center, Holon, Israel 58100
J Child Neurol 19:522-5. 2004..The unusual association of hyperekplexia and refractory status epilepticus in both children suggests that this is a new autosomal recessive syndrome, possibly a channelopathy affecting both the brain and the spinal cord...
- Identification of a de novo Lys304Gln mutation in the glycine receptor alpha-1 subunit gene in a Korean infant with hyperekplexiaHoon Chul Kang
Department of Pediatrics, Epilepsy Center, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea
Mov Disord 23:610-3. 2008..was evident from the fourth week of life, and he showed marked improvement in the startle response and muscle hypertonia after being administered phenobarbital and clonazepam...
- Aesthetic botulinum A toxin in the mid and lower face and neckJean Carruthers
Department of Ophthalmology, University of British Columbia, Vancouver, Canada
Dermatol Surg 29:468-76. 2003..Botulinum toxin type A (BOTOX formulation) is used extensively for smoothing hyperkinetic lines in the upper face. The use of botulinum toxin for aesthetic indications in the mid and lower face and neck is now becoming increasingly popular...
- A prospective, multicentre, randomized, double-blind, placebo-controlled trial of onabotulinumtoxinA to treat plantarflexor/invertor overactivity after strokeJohn Walter Dunne
Department of Neurology, Royal Perth Hospital, Western Australia, Australia
Clin Rehabil 26:787-97. 2012..To examine the safety and efficacy of onabotulinumtoxinA (Botox) for plantarflexor overactivity following stroke...
- Clinical value of combined electrophysiological and urodynamic recordings to assess sexual disorders in spinal cord injured menD M Schmid
Swiss Paraplegic Centre, University Hospital Balgrist, Zurich, Switzerland
Neurourol Urodyn 22:314-21. 2003..To assess the significance of combined neurophysiological and neurourological examinations for diagnosis of neurogenic male sexual dysfunction...
- Bladder injection of "naked" hSlo/pcDNA3 ameliorates detrusor hyperactivity in obstructed rats in vivoG J Christ
Department of Urology, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Am J Physiol Regul Integr Comp Physiol 281:R1699-709. 2001..These initial observations indicate a potential utility of gene therapy for urinary incontinence...
- Spastic movement disorder: impaired reflex function and altered muscle mechanicsVolker Dietz
Spinal Cord Injury Centre, University of Zurich, Switzerland
Lancet Neurol 6:725-33. 2007In clinical practice, signs of exaggerated tendon tap reflexes associated with muscle hypertonia are generally thought to be responsible for spastic movement disorders...
- A neuromuscular intervention for exercise-related medial leg painKatherine R Newsham
Department of Physical Therapy and Athletic Training, Saint Louis University, St Louis, MO, USA
J Sport Rehabil 21:54-62. 2012..Exercise-related medial leg pain (ERMLP) is a common complaint among athletes, and efforts toward rehabilitation are often unsuccessful...
- Asymmetric synthesis and determination of the absolute configuration of FK584, an agent for the treatment of overactive detrusorK Take
Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceuttical Co, Ltd, Osaka, Japan
Chem Pharm Bull (Tokyo) 48:1903-7. 2000..The absolute configuration of FK584 was determined to be S by X-ray crystallographic analysis of the salt of S-(+)-mandelic acid...
- Molecular mechanisms involving IGF-1 and myostatin to induce muscle hypertrophy as a therapeutic strategy for Duchenne muscular dystrophyK Patel
Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London England, UK
Acta Myol 24:230-41. 2005....
- Transvaginal electrical stimulation in the treatment of urinary incontinenceAlan J Wein
J Urol 174:1007. 2005
- Incontinent ileovesicostomy in the management of neurogenic bladder dysfunctionAnthony R Gauthier
Department of Urology, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
Neurourol Urodyn 22:142-6. 2003..To report outcome and urodynamic follow-up of incontinent ileovesicostomy in quadriplegic patients with neurogenic bladder...
- Conditional stimulation of the dorsal penile/clitoral nerve may increase cystometric capacity in patients with spinal cord injuryA L Dalmose
Institute of Experimental Clinical Research, Arhus University Hospital Skejby, Arhus N, Denmark
Neurourol Urodyn 22:130-7. 2003..To investigate the feasibility of conditional short duration electrical stimulation of the penile/clitoral nerve as treatment for detrusor hyperreflexia, the present study was initiated...
- Long-term effect of shock wave therapy on upper limb hypertonia in patients affected by strokeP Manganotti
Hand Surgery Department, Verona Hospital, University of Verona, Italy
Stroke 36:1967-71. 2005Spasticity is a disabling complication of stroke and different noninvasive treatments are used to reduce muscle hypertonia. Shock waves are defined as a sequence of single sonic pulses largely used in the treatment of diseases involving ..
- Neurological complications of respiratory syncytial virus infection: case series and review of literatureJohn J Millichap
Division of Neurology, Children s Memorial Hospital, North Western University Medical School, Chicago, Illinois, USA
J Child Neurol 24:1499-503. 2009..The authors' data suggest that the electroencephalogram provides a sensitive method for detection of neurological insult in this group of patients...
- Is oral baclofen effective in neonatal hypertonia?Elizabeth Schulz
Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912 3740, USA
J Child Neurol 27:197-9. 2012..Results of our study show that there is no overall decrease in tone during oral baclofen therapy in hypertonic preterm neonates...
- Hypertonicity increases rabbit atrium and pulmonary vein arrhythmogenesis: a potential contributor to the genesis of atrial fibrillationShih Huang Lee
Shin Kong Wu Ho Su Memorial Hospital and Department of Medicine, Fu Jen Catholic University, Taipei, Taiwan
Clin Exp Pharmacol Physiol 36:419-24. 2009..5. Hypertonicity plays an important role in the electrical activity of pulmonary vein and atrial cardiomyocytes, which may have a potential role in the pathophysiology of atrial fibrillation...
- Prospective assessment of tizanidine for spasticity due to acquired brain injuryJ M Meythaler
Department of Physical Medicine and Rehabilitation, University of Alabama School of Medicine, Birmingham, AL, USA
Arch Phys Med Rehabil 82:1155-63. 2001..To determine if orally delivered tizanidine will control spastic hypertonia due to acquired brain injury...
- Objective differences between overactive bladder patients with and without urodynamically proven detrusor overactivityMichael L Guralnick
Department of Urology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Int Urogynecol J 21:325-9. 2010..This paper aims to determine if there are differences between female overactive bladder (OAB) patients with and without urodynamic detrusor overactivity (DO)...
- Individualised resting hand splints for adults with acquired brain injury: a randomized, single blinded, single case designJodie Copley
Division of Occupational Therapy, School of Health and Rehabilitation Sciences, The University of Queensland, QLD, Australia
NeuroRehabilitation 32:885-98. 2013..To evaluate the effect of individualized resting mitt splints on hypertonicity (spasticity and tissue stiffness) and passive range of motion (PROM)...
- [Mental deficiency preceded by transitory hypertonic cerebral motor disorder]J Artigas
Unitat de Neuropediatria, , , Sabadell, Barcelona,
Rev Neurol 25:1013-5. 1997..2. Despite of the resolution of motor signs, persistence of different degrees of mental retardation. CONCLUSIONS: Our reported patients presented a peculiar pattern of progression within the wide variability of the cerebral palsy group...
- Prenatal methadone exposure and neonatal neurobehavioral functioningMartha L Velez
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Pediatr Res 66:704-9. 2009..The determination of the range of the methadone-exposed infant's neurobehavioral repertoire could guide the optimal treatment of all such infants, particularly those requiring only nonpharmacologic care...
- SpasticityVolker Dietz
Balgrist University Hospital, Zurich, Switzerland
Handb Clin Neurol 109:197-211. 2012..In clinical practice, signs of exaggerated tendon tap reflexes associated with muscle hypertonia are the consequence of spinal cord injury (SCI)...
- Inhibition of human detrusor contraction by a urothelium derived factorB Chaiyaprasithi
Department of Urology, University of Mainz, Mainz, Germany
J Urol 170:1897-900. 2003..We investigated whether the contractions of human detrusor strips elicited by the muscarinic agonist carbachol, electrical field stimulation, KCl or the neurokinin receptor agonist neurokinin A are affected by the urothelium...
- [Drug therapy of female urinary incontinence]C Hampel
Urologische Klinik, Johannes Gutenberg Universitat, Mainz
Urologe A 44:244-55. 2005..Future developments will help to further optimize the pharmacological therapy for female urinary incontinence...
- Neural control of abnormal movementTerence Sanger; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Mechanisms of Therapeutic Action in SCIMehdi M Mirbagheri; Fiscal Year: 2013..abstract_text> ..
- Childhood Motor Impairment and Assisted CommunicationTerence Sanger; Fiscal Year: 2004....
- NIH Task Force on Childhood Motor DisordersTerence Sanger; Fiscal Year: 2006..The ultimate objective is to improve the functional abilities and societal participation of children with motor disorders. ..
- Arm Kinematics in Hyperkinetic Cerebral PalsyTerence Sanger; Fiscal Year: 2005..Hlatky will guide the design and implementation of clinical trials and outcome measure validation. The proposal includes coursework in cellular and molecular neurobiology and in the design of clinical research studies. ..
- Natural History of Muscular & Reflex Changes in StrokeMEHDI MIRBAGHERI; Fiscal Year: 2004..The changes in passive and intrinsic stiffness are likely to be highly correlated with severity of spasticity and inversely correlated with recovery of function. ..
- Tetrahydrobiopterin in Hypoxia-Ischemia Induced Fetal Brain DysfunctionJeannette Vasquez Vivar; Fiscal Year: 2008..This information will likely define the use of tetrahydrobiopterin in the prevention and/or amelioration of H-I induced fetal brain dysfunction, which remains a major medical challenge. [unreadable] [unreadable] [unreadable]..
- Redox Modulation of Nitric Oxide in Olfactory Dysfunction after Fetal HypoxiaSidhartha Tan; Fiscal Year: 2008..This model system will be valuable in the study of other mechanisms of disease, plasticity, and recovery in the hitherto inaccessible fetus and prenatal programming of smell in diverse pathologies. [unreadable] [unreadable] [unreadable]..
- Superoxide Generation from eNOS: The Role of PterinsJEANNETTE M VASQUEZ VIVAR; Fiscal Year: 2010..Generally this proposal is aimed at understanding these fundamental mechanisms that should provide the basis for developing new and improved strategies in the prevention and treatment of atherosclerosis and CVD. ..
- Linking motor imagery to motor executionSheng Li; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..