muscle hypertonia

Summary

Summary: Abnormal increase in skeletal or smooth muscle tone. Skeletal muscle hypertonicity may be associated with PYRAMIDAL TRACT lesions or BASAL GANGLIA DISEASES.

Top Publications

  1. ncbi Urinary dysfunction and autonomic control in amyloid neuropathy
    Takashi Ito
    Neurology Dept, Chiba University, 1 8 1 Inohana Chuo ku, Chiba 260 8670, Japan
    Clin Auton Res 16:66-71. 2006
  2. ncbi Pathophysiological mechanisms of dominant and recessive GLRA1 mutations in hyperekplexia
    Seo Kyung Chung
    Institute of Life Science, School of Medicine, Swansea University, Swansea, United Kingdom
    J Neurosci 30:9612-20. 2010
  3. ncbi The genetics of hyperekplexia: more than startle!
    Robert J Harvey
    Department of Pharmacology, The School of Pharmacy, London WC1N 1AX, UK
    Trends Genet 24:439-47. 2008
  4. ncbi Procedure- and device-related complications of intrathecal baclofen administration for management of adult muscle hypertonia: a review
    Ivana Stetkarova
    Na Homolce Hospital, Prague, Czech Republic
    Neurorehabil Neural Repair 24:609-19. 2010
  5. ncbi Spasticity or reversible muscle hypertonia?
    Abdel Magid O Bakheit
    Moseley Hall Hospital, Birmingham B13 6JA, UK
    J Rehabil Med 43:556-7. 2011
  6. ncbi Paratonia: a Delphi procedure for consensus definition
    Johannes S M Hobbelen
    Physiotherapy Research Vitalis Zorggroep Eindhoven, Vlasmeersestraat 5, 5261 TA Vught, The Netherlands
    J Geriatr Phys Ther 29:50-6. 2006
  7. pmc Lower urinary tract function in dementia of Lewy body type
    R Sakakibara
    Neurology Department, Chiba University, Chuo Ku, Chiba 260 8670, Japan
    J Neurol Neurosurg Psychiatry 76:729-32. 2005
  8. ncbi Decreased sensory receptors P2X3 and TRPV1 in suburothelial nerve fibers following intradetrusor injections of botulinum toxin for human detrusor overactivity
    A Apostolidis
    Peripheral Neuropathy Unit, Hammersmith Hospital, Imperial College London, United Kingdom
    J Urol 174:977-82; discussion 982-3. 2005
  9. ncbi Success of repeat detrusor injections of botulinum a toxin in patients with severe neurogenic detrusor overactivity and incontinence
    Joachim Grosse
    Department of Urology, Berufsgenossenschaftliche Unfallklinik Murnau, Murnau, Germany
    Eur Urol 47:653-9. 2005
  10. ncbi Urgency of micturition and detrusor contractility in men with prostatic obstruction and overactive bladders
    A Cucchi
    Divisione di Urologia, Policlinico San Matteo, Pavia, Italy
    Neurourol Urodyn 24:202-6. 2005

Research Grants

  1. Neural control of abnormal movement
    Terence Sanger; Fiscal Year: 2006
  2. Mechanisms of Therapeutic Action in SCI
    Mehdi M Mirbagheri; Fiscal Year: 2013
  3. Childhood Motor Impairment and Assisted Communication
    Terence Sanger; Fiscal Year: 2004
  4. NIH Task Force on Childhood Motor Disorders
    Terence Sanger; Fiscal Year: 2006
  5. Arm Kinematics in Hyperkinetic Cerebral Palsy
    Terence Sanger; Fiscal Year: 2005
  6. Natural History of Muscular & Reflex Changes in Stroke
    MEHDI MIRBAGHERI; Fiscal Year: 2004
  7. Tetrahydrobiopterin in Hypoxia-Ischemia Induced Fetal Brain Dysfunction
    Jeannette Vasquez Vivar; Fiscal Year: 2008
  8. Redox Modulation of Nitric Oxide in Olfactory Dysfunction after Fetal Hypoxia
    Sidhartha Tan; Fiscal Year: 2008
  9. Superoxide Generation from eNOS: The Role of Pterins
    JEANNETTE M VASQUEZ VIVAR; Fiscal Year: 2010
  10. Linking motor imagery to motor execution
    Sheng Li; Fiscal Year: 2006

Detail Information

Publications196 found, 100 shown here

  1. ncbi Urinary dysfunction and autonomic control in amyloid neuropathy
    Takashi Ito
    Neurology Dept, Chiba University, 1 8 1 Inohana Chuo ku, Chiba 260 8670, Japan
    Clin Auton Res 16:66-71. 2006
    ..The underlying mechanisms of urinary dysfunction seem to involve postganglionic cholinergic and afferent somatic nerves...
  2. ncbi Pathophysiological mechanisms of dominant and recessive GLRA1 mutations in hyperekplexia
    Seo Kyung Chung
    Institute of Life Science, School of Medicine, Swansea University, Swansea, United Kingdom
    J Neurosci 30:9612-20. 2010
    ..This study also reports the first hyperekplexia mutation associated with a GlyR leak conductance, suggesting tonic channel opening as a new mechanism in neuronal ligand-gated ion channels...
  3. ncbi The genetics of hyperekplexia: more than startle!
    Robert J Harvey
    Department of Pharmacology, The School of Pharmacy, London WC1N 1AX, UK
    Trends Genet 24:439-47. 2008
    ....
  4. ncbi Procedure- and device-related complications of intrathecal baclofen administration for management of adult muscle hypertonia: a review
    Ivana Stetkarova
    Na Homolce Hospital, Prague, Czech Republic
    Neurorehabil Neural Repair 24:609-19. 2010
    Intrathecal baclofen (ITB) effectively reduces muscle hypertonia; however, associated complications influence its utility and acceptance.
  5. ncbi Spasticity or reversible muscle hypertonia?
    Abdel Magid O Bakheit
    Moseley Hall Hospital, Birmingham B13 6JA, UK
    J Rehabil Med 43:556-7. 2011
    ..In this report we propose an alternative terminology and explain the reasons for doing so...
  6. ncbi Paratonia: a Delphi procedure for consensus definition
    Johannes S M Hobbelen
    Physiotherapy Research Vitalis Zorggroep Eindhoven, Vlasmeersestraat 5, 5261 TA Vught, The Netherlands
    J Geriatr Phys Ther 29:50-6. 2006
    ..For this reason, we initiated a Delphi procedure with known experts in the field to establish an operational consensus definition of paratonia...
  7. pmc Lower urinary tract function in dementia of Lewy body type
    R Sakakibara
    Neurology Department, Chiba University, Chuo Ku, Chiba 260 8670, Japan
    J Neurol Neurosurg Psychiatry 76:729-32. 2005
    ..Lower urinary tract (LUT) function in DLB has not been fully delineated. We investigated LUT function in DLB by evaluating clinical and urodynamic data...
  8. ncbi Decreased sensory receptors P2X3 and TRPV1 in suburothelial nerve fibers following intradetrusor injections of botulinum toxin for human detrusor overactivity
    A Apostolidis
    Peripheral Neuropathy Unit, Hammersmith Hospital, Imperial College London, United Kingdom
    J Urol 174:977-82; discussion 982-3. 2005
    ..We investigated a possible effect of BoNT/A on human bladder afferent mechanisms by studying the sensory receptors P2X3 and TRPV1 in biopsies from patients with neurogenic or idiopathic DO...
  9. ncbi Success of repeat detrusor injections of botulinum a toxin in patients with severe neurogenic detrusor overactivity and incontinence
    Joachim Grosse
    Department of Urology, Berufsgenossenschaftliche Unfallklinik Murnau, Murnau, Germany
    Eur Urol 47:653-9. 2005
    ..When the patients develop botulinum resistance, subsequent injections might be less effective. Repeat injections in patients with severe neurogenic detrusor overactivity and incontinence were studied...
  10. ncbi Urgency of micturition and detrusor contractility in men with prostatic obstruction and overactive bladders
    A Cucchi
    Divisione di Urologia, Policlinico San Matteo, Pavia, Italy
    Neurourol Urodyn 24:202-6. 2005
    ..In men with prostatic obstruction and detrusor overactivity (DO), to ascertain whether urgency of micturition affects bladder contractility...
  11. ncbi Botulinum toxin: a new dimension in the treatment of lower urinary tract dysfunction
    Arun Sahai
    Urology 65:211. 2005
  12. ncbi [Urinary incontinence in the woman--pathophysiology and diagnosis]
    G Schär
    Frauenklinik, Kantonsspital Aarau
    Ther Umsch 60:249-56. 2003
    ..An urodynamic evaluation together with perineal ultrasound and cystoscopy is performed in patients with complex or recurrent urinary incontinence after surgery or with micturition disorders...
  13. ncbi Botulinum toxin A for treatment of neurogenic detrusor overactivity and incontinence in patients with spinal cord lesions
    Per Bagi
    Clinics for Urology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    Scand J Urol Nephrol 38:495-8. 2004
    ..To evaluate the efficacy of intravesical botulinum toxin A (BTA) in the treatment of severe neurogenic detrusor overactivity (NDO) with incontinence in patients with spinal cord lesions (SCLs)...
  14. ncbi [Urodynamic findings in patients with infantile cerebral palsy]
    S Bross
    Urologische Universitätsklinik, Klinikum Mannheim gGmbH, Mannheim
    Aktuelle Urol 35:54-7. 2004
    ..Aim of study was to evaluate the urodynamic findings in patients with infantile cerebral palsy...
  15. ncbi Treatment of neurogenic detrusor overactivity in spinal cord injured patients by conditional electrical stimulation
    J Hansen
    Center for Sensory Motor Interaction, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
    J Urol 173:2035-9. 2005
    ..The feasibility of automatic event driven electrical stimulation of the dorsal penile/clitoral nerve in the treatment of neurogenic detrusor overactivity (NDO) was evaluated in individuals with spinal cord injury...
  16. ncbi Urgency: the cornerstone symptom of overactive bladder
    Alan J Wein
    J Urol 173:2054. 2005
  17. ncbi Effect of botulinum toxin type A on cerebral palsy with upper limb spasticity
    Tsui Fen Yang
    Department of Physical Therapy, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Am J Phys Med Rehabil 82:284-9. 2003
    ..The objective of this study was to investigate the effects of botulinum toxin type A injections in reducing upper limb muscular spasticity and in improving motor function in children with cerebral palsy...
  18. ncbi Home uroflowmetry for the evaluation of boys with urinary incontinence
    Stephen Shei Den Yang
    Department of Urology, En Chu Kong Hospital, School of Medicine, Taipei Medical University, Taiwan
    J Urol 169:1505-7. 2003
    ..We recorded uroflowmetry at home in boys with urinary incontinence and correlated the results with videourodynamics...
  19. ncbi [Efficacy of botulinum toxin A for the treatment of detrusor hyperreflexia]
    P Denys
    Service de Medecine Physique et de Readaptation, Hopital Raymond Poincare, AP HP, Faculte de Medecine Paris Ile de France Ouest, 104, Boulevard Raymond Poincare, 92380 Garches, France
    Ann Readapt Med Phys 46:326-8. 2003
    ..To determinate the efficacy of botulinum toxin to treat refractory urinary incontinence due to bladder hyperreflexia...
  20. ncbi Bladder neck cinch for pediatric neurogenic outlet deficiency
    Charles E Bugg
    Division of Urology, University of Alabama at Birmingham and Childre s Hospital, Alabama 35233, USA
    J Urol 170:1501-3; discussion 1503-4. 2003
    ..We evaluated the effectiveness of a rectus fascia bladder neck cinch which applies circumferential pressure around the bladder neck and elevation as a means of increasing outlet resistance...
  21. ncbi [Minimally invasive, safe treatment of the neurogenic bladder with botulinum-A-toxin in children with myelomeningocele]
    L Lusuardi
    Department für Kinderurologie, Krankenhaus der Barmherzigen Schwestern, Linz A
    Aktuelle Urol 35:49-53. 2004
    ..The efficacy and durability of botulinum-A toxin in the treatment of detrusor hyperreflexia in myelomeningocele (MMC) children was evaluated prospectively...
  22. ncbi Preliminary observations of a synergistic bladder-sphincter relationship following spinal cord injury in a quadruped animal
    James S Walter
    Research Service, Department of Veterans Affairs, Edward Hines Jr Hospital, Hines, Illinois 60141, USA
    J Spinal Cord Med 26:372-9. 2003
    ..The objective of this study was to determine whether sensory input from the bladder produced synergistic or dyssynergic pelvic floor reflexes following SCI in an animal model...
  23. ncbi [Biofeedback for urinary bladder dysfunctions in childhood. Indications, practice and the results of therapy]
    J Hoang-Böhm
    Urologische Klinik, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg
    Urologe A 43:813-9. 2004
    ..After effective therapy, associated urinary tract infections and vesicoureterorenal reflux may disappear...
  24. ncbi Does posture affect cystometric parameters and diagnoses?
    A S Arunkalaivanan
    Department of Urodynamics and Urogynaecology, City Hospital, Dudley Road, Birmingham, B18 7QH, UK
    Int Urogynecol J Pelvic Floor Dysfunct 15:422-4; discussion 424. 2004
    ..Therefore, we recommend that sitting posture is preferred over lying position for performing cystometry...
  25. ncbi [Bamberg Discussions 2003. Diagnosis and therapy of urinary incontinence in diabetic patients]
    H Madersbacher
    Krankenpfl J 41:176-7. 2003
  26. ncbi Preliminary communication: urodynamic assessment of donepezil hydrochloride in patients with Alzheimer's disease
    Ryuji Sakakibara
    Department of Neurology, Chiba University, Chiba, Japan
    Neurourol Urodyn 24:273-5. 2005
    ..Donepezil hydrochloride, a central cholinergic drug, is widely used for improving cognitive decline in Alzheimer's disease (AD). We investigated whether donepezil might affect the lower urinary tract (LUT) function in AD...
  27. ncbi Distinguishing neurogenic from non-neurogenic detrusor overactivity: a urodynamic assessment of lower urinary tract symptoms in patients with and without Parkinson's disease
    Gina A Defreitas
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9110, USA
    Urology 62:651-5. 2003
    ..To examine the urodynamic (UDS) attributes of detrusor overactivity (DO) in patients with Parkinson's disease in comparison to DO in men without neurologic disease, in whom DO is presumably outlet obstruction induced...
  28. ncbi Trospium chloride for the treatment of detrusor instability in children
    P Lopez Pereira
    Department of Pediatric Urology, University Hospital La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain
    J Urol 170:1978-81. 2003
    ..We assessed the efficacy and most appropriate dosage of trospium chloride (TCl) for managing bladder instability in children as compared with a placebo...
  29. ncbi Resiniferatoxin for detrusor instability refractory to anticholinergics
    Paulo C R Palma
    Division of Urology, State University of Campinas, UNICAMP, Campinas, Sao Paulo, Brazil
    Int Braz J Urol 30:53-8. 2004
    ..We have evaluated the clinical and urodynamic effects of intravesical instillation of resiniferatoxin in patients with idiopathic detrusor instability refractory to anticholinergics...
  30. ncbi Can neurologic examination predict type of detrusor sphincter-dyssynergia in patients with spinal cord injury?
    Brigitte Schurch
    Department of Neuro Urology, Swiss Paraplegic Center, Balgrist University Hospital, Zurich, Switzerland
    Urology 65:243-6. 2005
    ....
  31. ncbi [Pathophysiology of urge, stress, and mixed incontinence]
    S Schumacher
    Department of Urology, Zayed Military Hospital, Abu Dhabi, V A E
    Urologe A 44:239-43. 2005
    ..Stress and urge incontinence can occur in combination and then be defined as mixed incontinence...
  32. ncbi Autoaugmentation by detrusor myotomy: its lack of effectiveness in the management of congenital neuropathic bladder
    Andrew E MacNeily
    Division of Pediatric Urology, British Columbia Children s Hospital, University of British Columbia, Vancouver, Canada
    J Urol 170:1643-6; discussion 1646. 2003
    ..We present our long-term results in 17 patients with myelomeningocele undergoing autoaugmentation by vesicomyotomy...
  33. ncbi Polyethylene glycol 3350 for constipation in children with dysfunctional elimination
    Brad A Erickson
    Division of Pediatric Urology, Children s Hospital of Iowa, Iowa City, USA
    J Urol 170:1518-20. 2003
    ..Polyethylene glycol 3350 (Miralax, Braintree Laboratories, Braintree, Massachusetts) is a nonaddictive, tasteless powder that can be mixed with any liquid for treatment of constipation...
  34. ncbi Urodynamic effect of intravesical resiniferatoxin in patients with neurogenic detrusor overactivity of spinal origin: results of a double-blind randomized placebo-controlled trial
    Carlos Silva
    Department of Urology, Hospital S Joao, 4200 319 Porto, Portugal
    Eur Urol 48:650-5. 2005
    ..To access by a placebo-controlled randomized clinical trial the effect of intravesical resiniferatoxin on the urodynamic parameters of patients with neurogenic detrusor overactivity (NDO) of spinal origin...
  35. ncbi [Management of urinary incontinence in the aging man]
    M Staehler
    Urologische Klinik und Poliklinik, Klinikum Grosshadern, LMU Munchen
    MMW Fortschr Med 147:29-32. 2005
    ..Moreover, the problem can be successfully controlled in the majority of the patients through very specific drug and surgical therapeutic concepts...
  36. ncbi Urodynamic study in the neurogenic bladder dysfunction caused by intervertebral disk hernia
    Dexin Dong
    Department of Urology, Qilu Hospital of Shandong University, Jinan, China
    Neurourol Urodyn 25:446-50. 2006
    ..To discuss the clinical significance of urodynamic studies in neurogenic bladder dysfunction caused by intervertebral disk hernia...
  37. pmc Safety and efficacy of tramadol in the treatment of idiopathic detrusor overactivity: a double-blind, placebo-controlled, randomized study
    M R Safarinejad
    Urology Nephrology Research Centre, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Br J Clin Pharmacol 61:456-63. 2006
    ..To evaluate the efficacy and safety of tramadol in patients with idiopathic detrusor overactivity (IDO)...
  38. ncbi Urodynamic distinctions between idiopathic detrusor overactivity and detrusor overactivity secondary to multiple sclerosis
    Gary E Lemack
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9110, USA
    Urology 67:960-4. 2006
    ....
  39. ncbi Trospium chloride in patients with neurogenic detrusor overactivity: is dose titration of benefit to the patients?
    M Menarini
    Spinal Cord Unit, Montecatone Rehabilitation Institute, Montecatone di Imola
    Int J Clin Pharmacol Ther 44:623-32. 2006
    ....
  40. ncbi Sacral bladder denervation for treatment of detrusor hyperreflexia and autonomic dysreflexia
    M Hohenfellner
    Department of Urology, Johannes Gutenberg-University, Mainz, Germany
    Urology 58:28-32. 2001
    ..It is only moderately invasive in nature, requires neither sophisticated nor expensive medical equipment, and is an attractive alternative to urinary diversion using intestinal segments...
  41. ncbi How many uncomplicated male and female overactive bladder patients reveal detrusor overactivity during urodynamic study?
    Noritoshi Sekido
    Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Int J Urol 13:1276-9. 2006
    ..We retrospectively evaluated the incidence of detrusor overactivity (DO) in uncomplicated overactive bladder syndrome (OAB) patients...
  42. ncbi Involuntary detrusor contractions: correlation of urodynamic data to clinical categories
    L J Romanzi
    Weill Medical College, Cornell University, New York, New York, USA
    Neurourol Urodyn 20:249-57. 2001
    ..However, the ability to abort IDC and stop incontinent flow may have prognostic implications, especially for the response to behavior modification, biofeedback, and pelvic floor exercise...
  43. ncbi Predictive value of initial urodynamic pattern on urinary continence in patients with myelomeningocele
    Thomas M Kessler
    Neuro urology unit, Department of Neurology, University Hospital Innsbruck, Innsbruck, Austria
    Neurourol Urodyn 25:361-7. 2006
    ..To investigate whether the initial urodynamic pattern may predict urinary continence and the need for adjunctive incontinence surgery in patients with myelomeningocele...
  44. ncbi Neurogenic bladder treatment by doubling the recommended antimuscarinic dosage
    M Horstmann
    Department of Urology, University of Tubingen, Tubingen, Germany
    Neurourol Urodyn 25:441-5. 2006
    ..All patients were suffering from neurogenic detrusor overactivity incontinence. Tolerability and success were evaluated in the present study...
  45. ncbi [Injections of botulinum toxin a into the detrusor vesicae for treatment of refractory detrusor hyperactivity in non-neurological patients]
    F Neugart
    Klinikum Offenburg, Klinik für Urologie und Kinderurologie, Offenburg
    Aktuelle Urol 37:212-7. 2006
    ..g., for treatment of detrusor hyperreflexia in neurogenic bladders. Several groups have evaluated the efficacy of the substance in patients with an anticholinergic-refractory detrusor hyperactivity without neurological disease...
  46. ncbi Efficacy of botulinum-a toxin in children with detrusor hyperreflexia due to myelomeningocele: preliminary results
    H Schulte-Baukloh
    Department of Urology, St Hedwig Hospital, Teaching Hospital of University Hospital Charité, Berlin, Germany
    Urology 59:325-7; discussion 327-8. 2002
    ..With the intent of avoiding surgery, we investigated the effect of botulinum-A toxin for treating detrusor hyperreflexia in this group of patients...
  47. ncbi Efficacy and safety of transdermal oxybutynin in patients with urge and mixed urinary incontinence
    Roger R Dmochowski
    Urology Associates of North Texas, Fort Worth, Texas, USA
    J Urol 168:580-6. 2002
    ..We evaluated the efficacy and safety of an oxybutynin transdermal delivery system (TDS) in a general population of patients with overactive bladder and urge or mixed urinary incontinence...
  48. ncbi A comparison between the response of patients with idiopathic detrusor overactivity and neurogenic detrusor overactivity to the first intradetrusor injection of botulinum-A toxin
    Roshni Popat
    Department of Uro Neurology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals, United Kingdom
    J Urol 174:984-9. 2005
    ..The purpose of this study was to investigate whether comparable efficacy could be displayed in the response of patients with IDO to those with NDO...
  49. ncbi [When is a urodynamic investigation indicated for overactive bladder?]
    S Schumacher
    Urologische Klinik und Poliklinik der Rheinischen Friedrich Wilhelms Universität Bonn
    Urologe A 42:801-6. 2003
    ..Diagnostic evaluation of geriatric patients with overactive bladder can usually be accomplished with a basic assessment while invasive procedures should be the exception...
  50. ncbi Urodynamic evaluation of the human bladder response to an increase in outlet resistance
    Jason D Engel
    Department of Urology, Northwestern University School of Medicine, Chicago, Illinois, USA
    Neurourol Urodyn 21:524-8. 2002
    ..We prospectively evaluated the response of the human bladder to a chronic increase in urethral resistance according to the indices of pressure, volume flow rate, total (external) bladder work, and maximum and average detrusor power...
  51. ncbi Urgency, botulinum toxin and how botulinum toxin can help urgency
    Michael B Chancellor
    J Urol 174:818. 2005
  52. ncbi [Pudendal nerve stimulation therapy of the overactive bladder -- an alternative to sacral neuromodulation?]
    C Seif
    Universitatsklinikum Schleswig Holstein, Campus Kiel, Klinik für Urologie und Kinderurologie
    Aktuelle Urol 36:234-8. 2005
    ..The BION-stimulator, which only measures 2.8 x 0.3 cm, is designed for pudendal nerve stimulation. Its implantation technique as well as the first clinical results are presented and discussed...
  53. ncbi [Subjective patient satisfaction after injection of botulinum-a toxin in detrusor overactivity]
    H Schulte-Baukloh
    Urologische Abteilung, St Hedwig Kliniken GmbH, Akademisches Lehrkrankenhaus der Universitätsmedizin Berlin, Campus Chárite, Berlin
    Aktuelle Urol 36:230-3. 2005
    ..We were particularly interested in patient satisfaction with this therapy...
  54. ncbi Comparative study of pressure-flow parameters
    Lars M Eri
    Department of Urology, Ullevaal University Hospital, Oslo, Norway
    Neurourol Urodyn 21:186-93. 2002
    ..In assessment of a large decrease in urethral resistance, such as after TURp, resistance parameters that are based on maximum flow rate as well as detrusor pressure are preferable...
  55. ncbi Spontaneous and experimental glycoprotein storage disease of goats induced by Ipomoea carnea subsp fistulosa (Convolvulaceae)
    A G Armien
    Institut für Veterinär Pathologie, Justus Liebig Universitat Giessen, Giessen, Germany
    Vet Pathol 44:170-84. 2007
    ..ataxia, posterior paresis, proprioceptive deficits, abnormal posture, abnormal postural reaction, and muscle hypertonia were necropsied. I fistulosa was suspected to be the cause of the neurologic disease in all cases...
  56. ncbi Evidence for a significant role of a Gs-triggered mechanism unrelated to the activation of adenylyl cyclase in the cyclic AMP-independent relaxant response of guinea-pig tracheal smooth muscle
    Yoshio Tanaka
    Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Miyama 2 2 1, Chiba 274 8510, Funabashi City, Japan
    Naunyn Schmiedebergs Arch Pharmacol 368:437-41. 2003
    ..This mechanism may account in part for the cyclic AMP-independent relaxant response of tracheal smooth muscle...
  57. ncbi GM1 gangliosidosis in adults: clinical and molecular analysis of 16 Japanese patients
    K Yoshida
    Department of Clinical Genetics, Tokyo Metropolitan Institute of Medical Science, Japan
    Ann Neurol 31:328-32. 1992
    ..Major clinical manifestations were gait and speech disturbances caused by persistent muscle hypertonia. Dystonic postures and movements, facial grimacing, and parkinsonian manifestations were commonly seen...
  58. ncbi [Focus on current research: improving the mobility of paraplegic patients]
    V Dietz
    Schweizerisches Paraplegikerzentrum, Universitätsklinik Balgrist, Zurich
    Schweiz Med Wochenschr 130:829-36. 2000
    ..symptoms and clinical (physical) signs suggests that the exaggerated tendon tap reflexes are responsible for muscle hypertonia and the latter causes the movement disorder...
  59. ncbi The pharmacology of the internal anal sphincter and new treatments of ano-rectal disorders
    T A Cook
    University Department of Pharmacology, John Radcliffe Hospital, Oxford, UK
    Aliment Pharmacol Ther 15:887-98. 2001
    ..Further understanding of the pharmacology of the internal anal sphincter may permit the development of new agents to selectively target the tissue with greater efficacy and fewer side-effects...
  60. ncbi Postural sway during single and repeated cold exposures
    Tiina M Mäkinen
    Centre for Arctic Medicine, Thule Institute, University of Oulu, P O Box 5000, FIN 90014 University of Oulu, Oulu, Finland
    Aviat Space Environ Med 76:947-53. 2005
    ..Tissue cooling changes sensory and neuromuscular functions that are also involved in postural control. The purpose of the study was to determine how acute and repeated exposures to cold affect whole body postural control...
  61. ncbi Botulinum toxin B increases mouth opening in patients with spastic trismus
    U M Fietzek
    Neurologisches Krankenhaus München, Center for Parkinson s disease and Movement Disorders, Parzivalplatz 4, D 80804 Munich, Germany
    Eur J Neurol 16:1299-304. 2009
    ..generalized spastic movement disorders of various aetiologies often involve the jaw muscles and lead to a spastic trismus with masseter muscle hypertonia. We report a placebo-controlled randomized study on patients with spastic trismus.
  62. ncbi [Age for sitting and walking in children born weighing less than 1,500 g and normal motor development at two years of age]
    C R Pallas Alonso
    Servicio de Neonatologia, Hospital 12 de Octubre, Madrid
    An Esp Pediatr 53:43-7. 2000
    ....
  63. ncbi A novel recessive hyperekplexia allele GLRA1 (S231R): genotyping by MALDI-TOF mass spectrometry and functional characterisation as a determinant of cellular glycine receptor trafficking
    Andreas Humeny
    Institut fur Biochemie, Emil Fischer Zentrum, Friedrich Alexander Universitat Erlangen Nurnberg, D91054 Erlangen, Germany
    Eur J Hum Genet 10:188-96. 2002
    ..STHE) is a hereditary neurological disorder characterised by an exaggerated startle response and infantile muscle hypertonia. Several autosomal dominant and recessive forms of the disorder have been associated with point mutations in ..
  64. ncbi Voluntary ankle flexor activity and adaptive coactivation gain is decreased by spasticity during subacute spinal cord injury
    J Gómez-Soriano
    Grupo Función Sensitivomotora, Hospital Nacional de Paraplejicos, SESCAM, Finca La Peraleda s n, 45071 Toledo, Spain
    Exp Neurol 224:507-16. 2010
    Although spasticity has been defined as an increase in velocity-dependent stretch reflexes and muscle hypertonia during passive movement, the measurement of flexor muscle paresis may better characterize the negative impact of this ..
  65. pmc The glycinergic system in human startle disease: a genetic screening approach
    Jeff S Davies
    Institute of Life Science, School of Medicine, Swansea University Singleton Park, Swansea, UK
    Front Mol Neurosci 3:8. 2010
    ....
  66. ncbi Hereditary hyperekplexia caused by novel mutations of GLRA1 in Turkish families
    Sandra L Gilbert
    Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA
    Mol Diagn 8:151-5. 2004
    ..Genetic studies have linked mutations in the gene encoding glycine receptor alpha1 (GLRA1) with hereditary hyperekplexia...
  67. pmc Progress in the understanding and treatment of chronic anal fissure
    K McCallion
    Department of Surgery, Queen s University, Belfast, UK
    Postgrad Med J 77:753-8. 2001
    ..Temporary reduction in sphincter tone can be achieved on an outpatient basis by applying a topical nitric oxide donor (for example, glyceryl trinitrate) or injecting botulinum toxin into the anal sphincter...
  68. ncbi [Basic principles of non-respiratory physiotherapy for neuromuscular diseases]
    I Watzek
    Neurologische Klinik der Friedrich Alexander Universität Erlangen Nürnberg
    Pneumologie 62:S28-30. 2008
    ..Loss of upper neurons leads to the development of spasticity and muscle hypertonia whereas muscular atrophy and weakness is a prominent feature of lower motor neuron loss...
  69. ncbi [Drug treatment for children with cerebral palsy]
    Hilla Ben-Pazi
    Pediatric Movement Disorders, Department of Child Neurology, Stanford Medical Center, CA 94305 5235, USA
    Harefuah 145:510-5, 550. 2006
    ..This motor dysfunction is caused by several motor components such as weakness, lack of motor control and muscle hypertonia. Drug treatment, delineated in this review, mainly addresses the latter...
  70. pmc A critical role for glycine transporters in hyperexcitability disorders
    Robert J Harvey
    Department of Pharmacology, The School of Pharmacy London, UK
    Front Mol Neurosci 1:1. 2008
    ..These findings highlight the importance of these transporters in regulating the levels of synaptic glycine...
  71. ncbi Botulinum toxin in post-stroke patients: stiffness modifications and clinical implications
    Giacinta Miscio
    Department of Neurology, Istituto Auxologico Italiano, IRCCS, Strada L Cadorna 90, 28824, Piancavallo Oggebbio VB, Italy
    J Neurol 251:189-96. 2004
    ..To objectively quantify stiffness and clinical changes in the upper limb of poststroke patients following botulinum toxin (BT) injection...
  72. pmc The relation between Ashworth scale scores and the excitability of the alpha motor neurones in patients with post-stroke muscle spasticity
    A M O Bakheit
    Peninsula Medical School and Plymouth Primary Care Trust, Plymouth, UK
    J Neurol Neurosurg Psychiatry 74:646-8. 2003
    ..The modified Ashworth scale (MAS) is the most widely used method for assessing muscle spasticity in clinical practice and research. However, the validity of this scale has been challenged...
  73. ncbi [New therapeutic methods for spasticity and dystonia in children with cerebral palsy require multidisciplinary team work. Comprehensive approach yields good results]
    Lena Westbom
    Barnneurologiska sektionen, Barn och ungdomssjukhuset, Universitetssjukhuset i Lund
    Lakartidningen 100:125-30. 2003
    ..We have found that a common structured and standardized follow-up programme with early intervention against muscle hypertonia and imbalance can prevent hip luxation and contractures in children with CP.
  74. ncbi A missense mutation in the gene encoding the alpha 1 subunit of the inhibitory glycine receptor in the spasmodic mouse
    S G Ryan
    Department of Pediatrics, University of Texas Health Science Center, San Antonio 78284
    Nat Genet 7:131-5. 1994
    ..We conclude that spd is a murine homologue of hyperekplexia and that mutations in GLRA1/Glra1 can produce syndromes with different inheritance patterns...
  75. ncbi Evidence for recessive as well as dominant forms of startle disease (hyperekplexia) caused by mutations in the alpha 1 subunit of the inhibitory glycine receptor
    M I Rees
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Hum Mol Genet 3:2175-9. 1994
    ..This suggests that human startle disease can display recessive as well as dominant inheritance resulting from different mutations in GLRA 1...
  76. ncbi [Symptomatic approach to musculoskeletal dysfunction and chronic pelvic and perineal pain]
    J J Labat
    Centre fédératif de pelvipérinéologie, Clinique Urologique, CHU de Nantes, 44093 Nantes, France
    Prog Urol 20:982-9. 2010
    Clinical examination of a patient with chronic pelvic and perineal pain often demonstrates muscle hypertonia or muscle contracture sometimes associated with local tenderness or real muscle trigger points...
  77. ncbi Familial hyperekplexia and refractory status epilepticus: a new autosomal recessive syndrome
    Tally Lerman-Sagie
    Metabolic Neuro Genetic Clinic, Wolfson Medical Center, Holon, Israel 58100
    J Child Neurol 19:522-5. 2004
    ..The unusual association of hyperekplexia and refractory status epilepticus in both children suggests that this is a new autosomal recessive syndrome, possibly a channelopathy affecting both the brain and the spinal cord...
  78. ncbi Identification of a de novo Lys304Gln mutation in the glycine receptor alpha-1 subunit gene in a Korean infant with hyperekplexia
    Hoon Chul Kang
    Department of Pediatrics, Epilepsy Center, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea
    Mov Disord 23:610-3. 2008
    ..was evident from the fourth week of life, and he showed marked improvement in the startle response and muscle hypertonia after being administered phenobarbital and clonazepam...
  79. ncbi Aesthetic botulinum A toxin in the mid and lower face and neck
    Jean Carruthers
    Department of Ophthalmology, University of British Columbia, Vancouver, Canada
    Dermatol Surg 29:468-76. 2003
    ..Botulinum toxin type A (BOTOX formulation) is used extensively for smoothing hyperkinetic lines in the upper face. The use of botulinum toxin for aesthetic indications in the mid and lower face and neck is now becoming increasingly popular...
  80. ncbi A prospective, multicentre, randomized, double-blind, placebo-controlled trial of onabotulinumtoxinA to treat plantarflexor/invertor overactivity after stroke
    John Walter Dunne
    Department of Neurology, Royal Perth Hospital, Western Australia, Australia
    Clin Rehabil 26:787-97. 2012
    ..To examine the safety and efficacy of onabotulinumtoxinA (Botox) for plantarflexor overactivity following stroke...
  81. ncbi Clinical value of combined electrophysiological and urodynamic recordings to assess sexual disorders in spinal cord injured men
    D M Schmid
    Swiss Paraplegic Centre, University Hospital Balgrist, Zurich, Switzerland
    Neurourol Urodyn 22:314-21. 2003
    ..To assess the significance of combined neurophysiological and neurourological examinations for diagnosis of neurogenic male sexual dysfunction...
  82. ncbi Bladder injection of "naked" hSlo/pcDNA3 ameliorates detrusor hyperactivity in obstructed rats in vivo
    G J Christ
    Department of Urology, Institute for Smooth Muscle Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1699-709. 2001
    ..These initial observations indicate a potential utility of gene therapy for urinary incontinence...
  83. ncbi Spastic movement disorder: impaired reflex function and altered muscle mechanics
    Volker Dietz
    Spinal Cord Injury Centre, University of Zurich, Switzerland
    Lancet Neurol 6:725-33. 2007
    In clinical practice, signs of exaggerated tendon tap reflexes associated with muscle hypertonia are generally thought to be responsible for spastic movement disorders...
  84. ncbi A neuromuscular intervention for exercise-related medial leg pain
    Katherine R Newsham
    Department of Physical Therapy and Athletic Training, Saint Louis University, St Louis, MO, USA
    J Sport Rehabil 21:54-62. 2012
    ..Exercise-related medial leg pain (ERMLP) is a common complaint among athletes, and efforts toward rehabilitation are often unsuccessful...
  85. ncbi Asymmetric synthesis and determination of the absolute configuration of FK584, an agent for the treatment of overactive detrusor
    K Take
    Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceuttical Co, Ltd, Osaka, Japan
    Chem Pharm Bull (Tokyo) 48:1903-7. 2000
    ..The absolute configuration of FK584 was determined to be S by X-ray crystallographic analysis of the salt of S-(+)-mandelic acid...
  86. ncbi Molecular mechanisms involving IGF-1 and myostatin to induce muscle hypertrophy as a therapeutic strategy for Duchenne muscular dystrophy
    K Patel
    Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London England, UK
    Acta Myol 24:230-41. 2005
    ....
  87. ncbi Transvaginal electrical stimulation in the treatment of urinary incontinence
    Alan J Wein
    J Urol 174:1007. 2005
  88. ncbi Incontinent ileovesicostomy in the management of neurogenic bladder dysfunction
    Anthony R Gauthier
    Department of Urology, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Neurourol Urodyn 22:142-6. 2003
    ..To report outcome and urodynamic follow-up of incontinent ileovesicostomy in quadriplegic patients with neurogenic bladder...
  89. ncbi Conditional stimulation of the dorsal penile/clitoral nerve may increase cystometric capacity in patients with spinal cord injury
    A L Dalmose
    Institute of Experimental Clinical Research, Arhus University Hospital Skejby, Arhus N, Denmark
    Neurourol Urodyn 22:130-7. 2003
    ..To investigate the feasibility of conditional short duration electrical stimulation of the penile/clitoral nerve as treatment for detrusor hyperreflexia, the present study was initiated...
  90. ncbi Long-term effect of shock wave therapy on upper limb hypertonia in patients affected by stroke
    P Manganotti
    Hand Surgery Department, Verona Hospital, University of Verona, Italy
    Stroke 36:1967-71. 2005
    Spasticity is a disabling complication of stroke and different noninvasive treatments are used to reduce muscle hypertonia. Shock waves are defined as a sequence of single sonic pulses largely used in the treatment of diseases involving ..
  91. ncbi Neurological complications of respiratory syncytial virus infection: case series and review of literature
    John J Millichap
    Division of Neurology, Children s Memorial Hospital, North Western University Medical School, Chicago, Illinois, USA
    J Child Neurol 24:1499-503. 2009
    ..The authors' data suggest that the electroencephalogram provides a sensitive method for detection of neurological insult in this group of patients...
  92. ncbi Is oral baclofen effective in neonatal hypertonia?
    Elizabeth Schulz
    Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912 3740, USA
    J Child Neurol 27:197-9. 2012
    ..Results of our study show that there is no overall decrease in tone during oral baclofen therapy in hypertonic preterm neonates...
  93. ncbi Hypertonicity increases rabbit atrium and pulmonary vein arrhythmogenesis: a potential contributor to the genesis of atrial fibrillation
    Shih Huang Lee
    Shin Kong Wu Ho Su Memorial Hospital and Department of Medicine, Fu Jen Catholic University, Taipei, Taiwan
    Clin Exp Pharmacol Physiol 36:419-24. 2009
    ..5. Hypertonicity plays an important role in the electrical activity of pulmonary vein and atrial cardiomyocytes, which may have a potential role in the pathophysiology of atrial fibrillation...
  94. ncbi Prospective assessment of tizanidine for spasticity due to acquired brain injury
    J M Meythaler
    Department of Physical Medicine and Rehabilitation, University of Alabama School of Medicine, Birmingham, AL, USA
    Arch Phys Med Rehabil 82:1155-63. 2001
    ..To determine if orally delivered tizanidine will control spastic hypertonia due to acquired brain injury...
  95. ncbi Objective differences between overactive bladder patients with and without urodynamically proven detrusor overactivity
    Michael L Guralnick
    Department of Urology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int Urogynecol J 21:325-9. 2010
    ..This paper aims to determine if there are differences between female overactive bladder (OAB) patients with and without urodynamic detrusor overactivity (DO)...
  96. ncbi Individualised resting hand splints for adults with acquired brain injury: a randomized, single blinded, single case design
    Jodie Copley
    Division of Occupational Therapy, School of Health and Rehabilitation Sciences, The University of Queensland, QLD, Australia
    NeuroRehabilitation 32:885-98. 2013
    ..To evaluate the effect of individualized resting mitt splints on hypertonicity (spasticity and tissue stiffness) and passive range of motion (PROM)...
  97. ncbi [Mental deficiency preceded by transitory hypertonic cerebral motor disorder]
    J Artigas
    Unitat de Neuropediatria, , , Sabadell, Barcelona,
    Rev Neurol 25:1013-5. 1997
    ..2. Despite of the resolution of motor signs, persistence of different degrees of mental retardation. CONCLUSIONS: Our reported patients presented a peculiar pattern of progression within the wide variability of the cerebral palsy group...
  98. pmc Prenatal methadone exposure and neonatal neurobehavioral functioning
    Martha L Velez
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Pediatr Res 66:704-9. 2009
    ..The determination of the range of the methadone-exposed infant's neurobehavioral repertoire could guide the optimal treatment of all such infants, particularly those requiring only nonpharmacologic care...
  99. ncbi Spasticity
    Volker Dietz
    Balgrist University Hospital, Zurich, Switzerland
    Handb Clin Neurol 109:197-211. 2012
    ..In clinical practice, signs of exaggerated tendon tap reflexes associated with muscle hypertonia are the consequence of spinal cord injury (SCI)...
  100. ncbi Inhibition of human detrusor contraction by a urothelium derived factor
    B Chaiyaprasithi
    Department of Urology, University of Mainz, Mainz, Germany
    J Urol 170:1897-900. 2003
    ..We investigated whether the contractions of human detrusor strips elicited by the muscarinic agonist carbachol, electrical field stimulation, KCl or the neurokinin receptor agonist neurokinin A are affected by the urothelium...
  101. ncbi [Drug therapy of female urinary incontinence]
    C Hampel
    Urologische Klinik, Johannes Gutenberg Universitat, Mainz
    Urologe A 44:244-55. 2005
    ..Future developments will help to further optimize the pharmacological therapy for female urinary incontinence...

Research Grants10

  1. Neural control of abnormal movement
    Terence Sanger; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  2. Mechanisms of Therapeutic Action in SCI
    Mehdi M Mirbagheri; Fiscal Year: 2013
    ..abstract_text> ..
  3. Childhood Motor Impairment and Assisted Communication
    Terence Sanger; Fiscal Year: 2004
    ....
  4. NIH Task Force on Childhood Motor Disorders
    Terence Sanger; Fiscal Year: 2006
    ..The ultimate objective is to improve the functional abilities and societal participation of children with motor disorders. ..
  5. Arm Kinematics in Hyperkinetic Cerebral Palsy
    Terence Sanger; Fiscal Year: 2005
    ..Hlatky will guide the design and implementation of clinical trials and outcome measure validation. The proposal includes coursework in cellular and molecular neurobiology and in the design of clinical research studies. ..
  6. Natural History of Muscular & Reflex Changes in Stroke
    MEHDI MIRBAGHERI; Fiscal Year: 2004
    ..The changes in passive and intrinsic stiffness are likely to be highly correlated with severity of spasticity and inversely correlated with recovery of function. ..
  7. Tetrahydrobiopterin in Hypoxia-Ischemia Induced Fetal Brain Dysfunction
    Jeannette Vasquez Vivar; Fiscal Year: 2008
    ..This information will likely define the use of tetrahydrobiopterin in the prevention and/or amelioration of H-I induced fetal brain dysfunction, which remains a major medical challenge. [unreadable] [unreadable] [unreadable]..
  8. Redox Modulation of Nitric Oxide in Olfactory Dysfunction after Fetal Hypoxia
    Sidhartha Tan; Fiscal Year: 2008
    ..This model system will be valuable in the study of other mechanisms of disease, plasticity, and recovery in the hitherto inaccessible fetus and prenatal programming of smell in diverse pathologies. [unreadable] [unreadable] [unreadable]..
  9. Superoxide Generation from eNOS: The Role of Pterins
    JEANNETTE M VASQUEZ VIVAR; Fiscal Year: 2010
    ..Generally this proposal is aimed at understanding these fundamental mechanisms that should provide the basis for developing new and improved strategies in the prevention and treatment of atherosclerosis and CVD. ..
  10. Linking motor imagery to motor execution
    Sheng Li; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..