tremor

Summary

Summary: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.

Top Publications

  1. ncbi Tremor reduction by subthalamic nucleus stimulation and medication in advanced Parkinson's disease
    Christian Blahak
    Department of Neurology, Universitäts klinikum Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Neurol 254:169-78. 2007
  2. pmc CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome
    Peter K Todd
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Neuron 78:440-55. 2013
  3. pmc Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J
    Clement Y Chow
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 448:68-72. 2007
  4. pmc Advances in clinical and molecular understanding of the FMR1 premutation and fragile X-associated tremor/ataxia syndrome
    Randi Hagerman
    Department of Pediatrics and the MIND Institute, University of California, Davis, School of Medicine, Davis, CA, USA
    Lancet Neurol 12:786-98. 2013
  5. pmc Role of hyperactive cerebellum and motor cortex in Parkinson's disease
    Hong Yu
    Department of Movement Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuroimage 35:222-33. 2007
  6. doi Course in Parkinson disease subtypes: A 39-year clinicopathologic study
    A H Rajput
    Division of Neurology, Department of Pathology, Saskatoon Health Region University of Saskatchewan, Canada
    Neurology 73:206-12. 2009
  7. pmc Fragile X-associated tremor/ataxia syndrome (FXTAS): pathology and mechanisms
    Paul Hagerman
    Department of Biochemistry and Molecular Medicine, and the MIND Institute, University of California, Davis, Health System, 4303 Tupper Hall, One Shields Ave, Davis, CA 95616, USA
    Acta Neuropathol 126:1-19. 2013
  8. ncbi Paradoxical aspects of parkinsonian tremor
    Paul S Fishman
    Department of Neurology, University of Maryland, School of Medicine and The Baltimore VAMC, Baltimore, Maryland 21201, USA
    Mov Disord 23:168-73. 2008
  9. doi Rapid tremor frequency assessment with the iPhone accelerometer
    Raed A Joundi
    Department of Physiology, Anatomy, and Genetics, Oxford University, UK
    Parkinsonism Relat Disord 17:288-90. 2011
  10. pmc Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits?
    Rick C Helmich
    Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6500 HB Nijmegen, The Netherlands, The Netherlands
    Brain 135:3206-26. 2012

Research Grants

  1. Exome re-sequencing candidate loci for familial essential tremor
    Barry E Kosofsky; Fiscal Year: 2012
  2. Donald M Kuhn; Fiscal Year: 2016
  3. Laurie J Ozelius; Fiscal Year: 2016
  4. The Ethics of Fragile X Genetic Screening and Testing Across the Lifespan
    Kruti Acharya; Fiscal Year: 2012
  5. Clinical center for the study of neuroprotection from PD
    Joseph Jankovic; Fiscal Year: 2013
  6. Scheduled and Responsive Brain Stimulation for the Treatment of Tourette Syndrome
    Michael S Okun; Fiscal Year: 2010
  7. Susan M Rivera; Fiscal Year: 2016
  8. Human iPSC neuronal models for early and late phases of FXTAS neurodegeneration
    Paul J Hagerman; Fiscal Year: 2010
  9. Effects on Caffeine on Adolescent Behavior and Physiology
    Jennifer L Temple; Fiscal Year: 2010
  10. Matthew Klein; Fiscal Year: 2014

Detail Information

Publications435 found, 100 shown here

  1. ncbi Tremor reduction by subthalamic nucleus stimulation and medication in advanced Parkinson's disease
    Christian Blahak
    Department of Neurology, Universitäts klinikum Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Neurol 254:169-78. 2007
    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has proved to be effective for tremor in Parkinson's disease (PD). Most of the recent studies used only clinical data to analyse tremor reduction...
  2. pmc CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome
    Peter K Todd
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Neuron 78:440-55. 2013
    Fragile X-associated tremor ataxia syndrome (FXTAS) results from a CGG repeat expansion in the 5' UTR of FMR1...
  3. pmc Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J
    Clement Y Chow
    Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 448:68-72. 2007
    ..neuronal degeneration in the central nervous system, peripheral neuronopathy and diluted pigmentation in the 'pale tremor' mouse...
  4. pmc Advances in clinical and molecular understanding of the FMR1 premutation and fragile X-associated tremor/ataxia syndrome
    Randi Hagerman
    Department of Pediatrics and the MIND Institute, University of California, Davis, School of Medicine, Davis, CA, USA
    Lancet Neurol 12:786-98. 2013
    ..hyperactivity disorder, autism spectrum disorder, seizure disorder) and neurodegenerative (fragile X-associated tremor/ataxia syndrome [FXTAS]) phenotypes through an entirely distinct molecular mechanism involving increased FMR1 mRNA ..
  5. pmc Role of hyperactive cerebellum and motor cortex in Parkinson's disease
    Hong Yu
    Department of Movement Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuroimage 35:222-33. 2007
    ..Our findings also provide the first evidence from neuroimaging that hyperactivation in the contralateral primary motor cortex is not a compensatory response but is directly related to upper limb rigidity...
  6. doi Course in Parkinson disease subtypes: A 39-year clinicopathologic study
    A H Rajput
    Division of Neurology, Department of Pathology, Saskatoon Health Region University of Saskatchewan, Canada
    Neurology 73:206-12. 2009
    ..Several studies indicate that the outcome is more favorable in tremor dominant (TD) cases but others report no difference...
  7. pmc Fragile X-associated tremor/ataxia syndrome (FXTAS): pathology and mechanisms
    Paul Hagerman
    Department of Biochemistry and Molecular Medicine, and the MIND Institute, University of California, Davis, Health System, 4303 Tupper Hall, One Shields Ave, Davis, CA 95616, USA
    Acta Neuropathol 126:1-19. 2013
    Since its discovery in 2001, our understanding of fragile X-associated tremor/ataxia syndrome (FXTAS) has undergone a remarkable transformation...
  8. ncbi Paradoxical aspects of parkinsonian tremor
    Paul S Fishman
    Department of Neurology, University of Maryland, School of Medicine and The Baltimore VAMC, Baltimore, Maryland 21201, USA
    Mov Disord 23:168-73. 2008
    Although resting tremor is the most identifiable sign of Parkinson's disease, its underlying basis appears to be the most complex of the cardinal signs...
  9. doi Rapid tremor frequency assessment with the iPhone accelerometer
    Raed A Joundi
    Department of Physiology, Anatomy, and Genetics, Oxford University, UK
    Parkinsonism Relat Disord 17:288-90. 2011
    The physician is often seeking more efficient ways of performing patient assessments. Currently, measuring tremor frequency requires expensive and bulky equipment...
  10. pmc Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits?
    Rick C Helmich
    Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6500 HB Nijmegen, The Netherlands, The Netherlands
    Brain 135:3206-26. 2012
    b>Tremor in Parkinson's disease has several mysterious features...
  11. ncbi FMR1 RNA within the intranuclear inclusions of fragile X-associated tremor/ataxia syndrome (FXTAS)
    Flora Tassone
    Department of Biochemistry and Molecular Medicine, University of California, Davis School of Medicine, Davis, California 95616, USA
    RNA Biol 1:103-5. 2004
    Fragile X-associated tremor/ataxia syndrome (FXTAS) is a recently identified neurodegenerative disorder affecting older adult males with premutation alleles of the fragile X mental retardation 1 (FMR1) gene...
  12. ncbi Effects of long-term organophosphate exposures on neurological symptoms, vibration sense and tremor among South African farm workers
    L London
    Department of Community Health, University of Cape Town, Observatory, South Africa
    Scand J Work Environ Health 24:18-29. 1998
    This study assessed the relationship between long-term exposure to organophosphate insecticides and neurological symptoms, vibration sense, and motor tremor after control for the effect of past poisoning and acute exposure.
  13. ncbi Synchronized neuronal discharge in the basal ganglia of parkinsonian patients is limited to oscillatory activity
    Ron Levy
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 22:2855-61. 2002
    ..In the five pallidotomy patients without limb tremor during the procedure, none of the 73 GPi pairs and 15 GPe pairs displayed synchronous activity...
  14. ncbi Effects of subthalamic nucleus stimulation and medication on resting and postural tremor in Parkinson's disease
    Molly M Sturman
    Department of Movement Sciences M C 994, College of Applied Health Sciences, University of Illinois at Chicago, 808 S Wood Street, 690 CME, Chicago, IL 60612, USA
    Brain 127:2131-43. 2004
    ..DBS) of the subthalamic nucleus (STN) and antiparkinsonian medication have proved to be effective treatments for tremor in Parkinson's disease...
  15. ncbi Changes in motor subtype and risk for incident dementia in Parkinson's disease
    Guido Alves
    The Norwegian Center for Movement Disorders, Stavanger, Norway
    Mov Disord 21:1123-30. 2006
    ..The motor subtype of Parkinsonism was classified into tremor-dominant (TD), indeterminate, or postural instability gait difficulty (PIGD) subtype at each visit, based on ..
  16. ncbi Voxel-based morphometry shows no decreases in cerebellar gray matter volume in essential tremor
    C Daniels
    Department of Neurology, Christian Albrechts University Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany
    Neurology 67:1452-6. 2006
    To investigate cerebellar gray matter volume in patients with essential tremor (ET).
  17. doi Levodopa affects functional brain networks in Parkinsonian resting tremor
    Bettina Pollok
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Mov Disord 24:91-8. 2009
    Resting tremor in idiopathic Parkinson's disease (PD) is associated with an oscillatory network comprising cortical as well as subcortical brain areas...
  18. doi Imaging coherent sources of tremor related EEG activity in patients with Parkinson's disease
    M Muthuraman
    Institute for Circuit and System Theory, University of Kiel, D 24143 Germany
    Conf Proc IEEE Eng Med Biol Soc 2008:4716-9. 2008
    The cortical sources of both the basic and first 'harmonic' frequency of Parkinsonian tremor are addressed in this paper...
  19. doi Milestones in tremor research
    Rodger Elble
    Department of Neurology, Southern Illinois University School of Medicine, Springfield, Illinois, USA
    Mov Disord 26:1096-105. 2011
    b>Tremor is one of the most frequent movement disorders and covers a wide spectrum of entities summarized in the 1998 consensus statement of the Movement Disorder Society...
  20. doi Believing is perceiving: mismatch between self-report and actigraphy in psychogenic tremor
    Isabel Pareés
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Brain 135:117-23. 2012
    We assessed the duration and severity of tremor in a real-life ambulatory setting in patients with psychogenic and organic tremor by actigraphy, and compared this with self-reports of tremor over the same period...
  21. doi Temporal discrimination in patients with dystonia and tremor and patients with essential tremor
    Michele Tinazzi
    Department of Neurological, Psychological, Morphological and Motor Sciences, University of Verona, Verona, Italy
    Neurology 80:76-84. 2013
    To investigate whether psychophysical techniques assessing temporal discrimination could help in differentiating patients who have tremor associated with dystonia or essential tremor.
  22. ncbi Electrophysiological mapping for the implantation of deep brain stimulators for Parkinson's disease and tremor
    Robert E Gross
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mov Disord 21:S259-83. 2006
    ..during the implantation of deep brain stimulation (DBS) leads for the treatment of Parkinson's disease and tremor. This review discusses the techniques used for physiological mapping and addresses the questions of how various ..
  23. ncbi Subthalamic-thalamic DBS in a case with spinocerebellar ataxia type 2 and severe tremor-A unusual clinical benefit
    Hans Joachim Freund
    Institute of Neuroscience and Biophysics 3, Research Center Julich, Julich, Germany
    Mov Disord 22:732-5. 2007
    This is a single case report of a patient with spinocerebellar ataxia type 2 (SCA2) and severe tremor. Whereas disease progression with prevailing ataxia and dysmetria was slow over the first symptomatic 6 years, 6 months prior to ..
  24. ncbi Tremor in Parkinson's disease and serotonergic dysfunction: an 11C-WAY 100635 PET study
    M Doder
    Division of Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK
    Neurology 60:601-5. 2003
    The pathophysiologic mechanisms underlying parkinsonian tremor remain unclear. The response to dopaminergic treatment is variable and nondopaminergic mechanisms may play a role in tremor generation...
  25. ncbi Physiological and pathological tremors and rhythmic central motor control
    J H McAuley
    Human Movement and Balance Unit, Institute of Neurology, London, UK
    Brain 123:1545-67. 2000
    ..It is thought that physiological tremor may be a manifestation in the periphery of such central oscillatory activity and that some pathological tremors ..
  26. ncbi GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum
    Chi Sung Chiu
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 25:3234-45. 2005
    ..Mouse GAT1 (mGAT1) KO mice exhibit motor disorders, including gait abnormality, constant 25-32 Hz tremor, which is aggravated by flunitrazepam, reduced rotarod performance, and reduced locomotor activity in the home ..
  27. ncbi Thalamic gray matter changes in unilateral Parkinsonian resting tremor: a voxel-based morphometric analysis of 3-dimensional magnetic resonance imaging
    Jan Kassubek
    Department of Neurology, University of Freiburg, Breisacher Strasse 64, 79106, Freiburg, Germany
    Neurosci Lett 323:29-32. 2002
    The thalamus is assumed to be involved in the generation of Parkinsonian tremor. Ten patients with tremor-dominant idiopathic Parkinson's disease (IPD) and strictly unilateral resting tremor were investigated by cerebral high-resolution 3-..
  28. pmc Evaluation of three different ways of assessing tremor in multiple sclerosis
    S H Alusi
    Department of Neurosciences, Imperial College School of Medicine, London, UK
    J Neurol Neurosurg Psychiatry 68:756-60. 2000
    To examine the comparative reliability and validity of three simple ways of rating upper limb tremor in patients with multiple sclerosis.
  29. ncbi Effect of visual information on step-tracking movements in patients with intention tremor due to multiple sclerosis
    P Feys
    Katholieke Universiteit Leuven, Department of Kinesiology, Leuven, Belgium
    Mult Scler 9:492-502. 2003
    The effect of visual information on step-tracking movements was studied in 18 patients with intention tremor due to multiple sclerosis (MS) and 15 healthy controls...
  30. pmc Tremor in multiple sclerosis
    Marcus Koch
    Department of Neurology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Neurol 254:133-45. 2007
    b>Tremor is estimated to occur in about 25 to 60 percent of patients with multiple sclerosis (MS). This symptom, which can be severely disabling and embarrassing for patients, is difficult to manage...
  31. doi Pallidal dysfunction drives a cerebellothalamic circuit into Parkinson tremor
    Rick C Helmich
    Donders Institute for Brain, Cognition, and Behavior, Center for Cognitive NeuroImaging, Radboud University Nijmegen, The Netherlands
    Ann Neurol 69:269-81. 2011
    ..striatal dopamine depletion, which explains clinical symptoms such as bradykinesia and rigidity, but not resting tremor. Instead, resting tremor is associated with increased activity in a distinct cerebellothalamic circuit...
  32. ncbi The metabolic substrates of bradykinesia and tremor in uncomplicated Parkinson's disease
    C Lozza
    INSERM U320, Centre Cyceron, Caen, France
    Neuroimage 17:688-99. 2002
    The pathophysiological mechanisms of bradykinesia and resting tremor, i.e., two major features of Parkinson's disease (PD), remain incompletely understood despite extensive studies, including functional imaging investigations...
  33. pmc Re-emergent tremor of Parkinson's disease
    J Jankovic
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurol Neurosurg Psychiatry 67:646-50. 1999
    To characterise postural tremors in patients with Parkinson's disease. Rest tremor is a well recognised cardinal symptom of Parkinson's disease, but postural tremors associated with the disease may cause more disability than the more ..
  34. ncbi Pathophysiology of nonparkinsonian tremors
    Gunther Deuschl
    Department of Neurology, Christian Albrechts Universitat, Kiel, Germany
    Mov Disord 17:S41-8. 2002
    ..We summarize the present pathophysiological knowledge of these conditions. Essential tremor (ET) may be due to oscillations within the olivocerebellar circuit...
  35. ncbi The detection of tremor during slow alternating movements performed by patients with early Parkinson's disease
    Christian Duval
    Faculty of Applied Health Sciences, Brock University, 500 Glenridge Avenue, St Catharines, Ontario, L2S 3A1, Canada
    Exp Brain Res 154:395-8. 2004
    The present study demonstrates that tremor can be detected during slow alternating movements (SAM) performed by patients with early Parkinson's disease (PD) and that its relative amplitude is strongly correlated with patients' rest and ..
  36. ncbi Is the spinal cord the generator of 16-Hz orthostatic tremor?
    Jonathan A Norton
    MRC Human Movement Group, Sobell Research Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Neurology 62:632-4. 2004
    Primary orthostatic tremor is characterized by 16-Hz motor activity that is coherent between muscles. It has been suggested that this tremor originates in the brain...
  37. ncbi The impact of ventrolateral thalamotomy on high-frequency components of tremor
    Christian Duval
    Faculty of Applied Health Science, Brock University, 500 Glenridge Avenue, St Catharines, Ont, Canada H2S 3A1
    Clin Neurophysiol 116:1391-9. 2005
    The present study assessed the impact of ventrolateral (VL) thalamotomy on the high-frequency components of tremor in patients with Parkinson's disease (PD).
  38. doi Two novel POLG1 mutations in a patient with progressive external ophthalmoplegia, levodopa-responsive pseudo-orthostatic tremor and parkinsonism
    Federica Invernizzi
    Unit of Molecular Neurogenetics, Pierfranco e Luisa Mariani Center for the Study of Children s Mitochondrial Disorders, C Besta Neurological Institute Foundation IRCCS, Milan, Italy
    Neuromuscul Disord 18:460-4. 2008
    ..mutations in POLG1 in a compound heterozygous patient with autosomal recessive PEO, followed by pseudo-orthostatic tremor evolving into levodopa-responsive parkinsonism...
  39. doi Tremor-correlated neuronal activity in the subthalamic nucleus of Parkinsonian patients
    Florian Amtage
    Department of Neurology and Neurophysiology, University of Freiburg, Freiburg, Germany
    Neurosci Lett 442:195-9. 2008
    b>Tremor in Parkinson's disease (PD) is generated by an oscillatory neuronal network consisting of cortex, basal ganglia and thalamus...
  40. doi Rapid response of parkinsonian tremor to STN-DBS changes: direct modulation of oscillatory basal ganglia activity?
    Christian Blahak
    Department of Neurology, Universitaetsklinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Mov Disord 24:1221-5. 2009
    Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) has proved to be effective for tremor and other cardinal symptoms in Parkinson's disease (PD), the precise mechanisms of action of DBS are still unclear...
  41. doi Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms
    Maria C Rodriguez-Oroz
    Department of Neurology, Clinica Universitaria and Medical School and Neuroscience, CIMA, University of Navarra, Pamplona, Spain
    Lancet Neurol 8:1128-39. 2009
    ..The main motor features (ie, tremor, rigidity, and akinesia) are associated with a deficiency of dopamine in the posterior putamen and the motor ..
  42. doi The influence of muscle tremor on shooting performance
    Martin Lakie
    School of Sport and Exercise Sciences, Applied Physiology Research Group, University of Birmingham, Birmingham B15 2TT, UK
    Exp Physiol 95:441-50. 2010
    Shooting ability is compromised by involuntary movement. Some of this movement is physiological tremor. Tremor size has a demonstrable inverse correlation with shooting performance...
  43. ncbi Prediction of Parkinson's disease tremor onset using a radial basis function neural network based on particle swarm optimization
    Defeng Wu
    Automation Research Centre, Dalian Maritime University, China
    Int J Neural Syst 20:109-16. 2010
    ..PCA) with Local Field Potential (LFP) data recorded via the stimulation electrodes to predict activity related to tremor onset...
  44. pmc Ca(V)3.1 is a tremor rhythm pacemaker in the inferior olive
    Young Gyun Park
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    Proc Natl Acad Sci U S A 107:10731-6. 2010
    ..for the timing of motor coordination, and the abnormal potentiation of this mechanism may lead to a pathological tremor. Here, we show that the potentiation of Ca(V)3...
  45. doi Estimation and filtering of physiological tremor for real-time compensation in surgical robotics applications
    K C Veluvolu
    School of Electronics Engineering, College of IT Engineering, Kyungpook National University, Daegu, South Korea
    Int J Med Robot 6:334-42. 2010
    Physiological tremor is the main cause of imprecision in microsurgical procedures/robotics applications...
  46. pmc RNA-mediated neurodegeneration in fragile X-associated tremor/ataxia syndrome
    Yujing Li
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA
    Brain Res 1462:112-7. 2012
    ..Fragile X-associated tremor/ataxia syndrome (FXTAS), a late-onset neurodegenerative disorder, has been recognized in older male fragile X ..
  47. pmc Subcortical neuronal ensembles: an analysis of motor task association, tremor, oscillations, and synchrony in human patients
    Timothy L Hanson
    Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA
    J Neurosci 32:8620-32. 2012
    ..During DBS surgeries in 25 human patients with either essential tremor or Parkinson's disease, we acutely recorded the single-unit activity of 274 ventral intermediate/ventral oralis ..
  48. pmc White matter hyperintensities in Parkinson's disease: do they explain the disparity between the postural instability gait difficulty and tremor dominant subtypes?
    Talia Herman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    PLoS ONE 8:e55193. 2013
    ..PD) is traditionally sub-classified into the postural instability gait difficulty (PIGD) sub-type, and the tremor dominant (TD) sub-type...
  49. ncbi Electrophysiological confirmation of the zona incerta as a target for surgical treatment of disabling involuntary arm movements in multiple sclerosis: use of local field potentials
    D Nandi
    University Laboratory of Physiology, Oxford University, Parks Road, Oxford, OX1 3PT, UK
    J Clin Neurosci 9:64-8. 2002
    Lesioning or chronic deep brain stimulation (DBS) of the nucleus ventralis intermedius results in abolition of tremor in the contralateral limbs in Parkinson's disease (PD) and also in essential tremor...
  50. doi Akineto-rigid vs. tremor syndromes in Parkinsonism
    Adam Zaidel
    Department of Physiology, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Curr Opin Neurol 22:387-93. 2009
    Akinesia, rigidity and low-frequency rest tremor are the three cardinal motor signs of Parkinson's disease and some Parkinson's disease animal models. However, cumulative evidence supports the view that akinesia/rigidity vs...
  51. doi Cortical correlates of the basic and first harmonic frequency of Parkinsonian tremor
    Jan Raethjen
    Department of Neurology, University of Kiel, Schittenhelmstr 10, 24105 Kiel, Germany
    Clin Neurophysiol 120:1866-72. 2009
    It has been hypothesized that the basic and first harmonic frequency of Parkinsonian tremor are somewhat independent oscillations the biological basis of which remains unclear.
  52. ncbi Ten-Hertz stimulation of subthalamic nucleus deteriorates motor symptoms in Parkinson's disease
    Lars Timmermann
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Mov Disord 19:1328-33. 2004
    ..This finding indicates the clinical relevance of pathological 10 Hz synchronization in PD...
  53. pmc A telemedicine instrument for remote evaluation of tremor: design and initial applications in fatigue and patients with Parkinson's disease
    Mário C Barroso Júnior
    Biomedical Instrumentation Laboratory State University of Rio de Janeiro, Rio de Janeiro, Brazil
    Biomed Eng Online 10:14. 2011
    ..b>Tremor transduction is carried out by accelerometers, and the data processing, presentation and storage were obtained by ..
  54. pmc Real-time estimation of pathological tremor parameters from gyroscope data
    Juan A Gallego
    Bioengineering Group, Consejo Superior de Investigaciones Cientificas, CSIC, Ctra Campo Real, km 0 2 La Poveda, 28500, Arganda del Rey, Spain
    Sensors (Basel) 10:2129-49. 2010
    This paper presents a two stage algorithm for real-time estimation of instantaneous tremor parameters from gyroscope recordings...
  55. ncbi Tremor and dopamine agonists
    Rodger J Elble
    Department of Neurology, Southern Illinois University School of Medicine, Springfield, IL 62794 9643, USA
    Neurology 58:S57-62. 2002
    Although all dopaminergic drugs are effective in reducing tremor, no single drug has been shown to be clearly superior in the treatment of tremor...
  56. ncbi Disappearance of resting tremor after thalamic stroke involving the territory of the tuberothalamic artery
    Seong Min Choi
    Department of Neurology, Chonnam National University Medical School, Republic of Korea
    Parkinsonism Relat Disord 14:373-5. 2008
    Disappearance of resting tremor was observed in a 76-year-old patient with Parkinson's disease after a contralateral thalamic infarct involving the territory of the tuberothalamic artery...
  57. ncbi Bilateral stimulation of the caudal zona incerta nucleus for tremor control
    P Plaha
    Institute of Neurosciences, Frenchay Hospital, Bristol BS16 1LE, UK
    J Neurol Neurosurg Psychiatry 79:504-13. 2008
    ..VL) nucleus of the thalamus is the commonly chosen target for deep brain stimulation (DBS) to alleviate tremor. However, it has a poor efficacy in alleviating proximal tremor and patients may develop tolerance to the action ..
  58. pmc Kinematic optimization of deep brain stimulation across multiple motor symptoms in Parkinson's disease
    Thomas Mera
    Division of Movement Disorders, Cleveland Medical Devices, Inc, 4415 Euclid Ave Suite 400, Cleveland, OH 44103, USA
    J Neurosci Methods 198:280-6. 2011
    Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms including tremor and bradykinesia (slowness of movement)...
  59. ncbi Myoclonus or tremor in orthostatism: an under-recognized cause of unsteadiness in Parkinson's disease
    Smaranda Leu-Semenescu
    Department of Neurology, Saint Antoine Hospital, AP HP, Paris, France
    Mov Disord 22:2063-9. 2007
    ..In some cases these symptoms remain unexplained, and rare cases of unsteadiness have been attributed to tremor on standing...
  60. doi Disruption of nigrostriatal and cerebellothalamic pathways in dopamine responsive Holmes' tremor
    S Seidel
    Department of Neurology, Medical University Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    J Neurol Neurosurg Psychiatry 80:921-3. 2009
    Holmes' tremor is an unusual combination of rest, postural and kinetic tremor of the extremities. Medical treatment of this condition still remains unsatisfactory...
  61. doi A longitudinal study of tremor frequencies in Parkinson's disease and essential tremor
    B Hellwig
    Neurologische Universitatsklinik, Neurozentrum, Breisacher Strasse 64, 79106 Freiburg, Germany
    Clin Neurophysiol 120:431-5. 2009
    There is evidence that the tremor frequency in essential tremor (ET) decreases with time. Longitudinal studies on the evolution of tremor frequencies in Parkinson's disease (PD) have so far not been published...
  62. doi Synchronous pattern distinguishes resting tremor associated with essential tremor from rest tremor of Parkinson's disease
    R Nistico
    Neuroimaging Research Unit, National Research Council, Catanzaro, Italy
    Parkinsonism Relat Disord 17:30-3. 2011
    Rest tremor associated with essential tremor (ET) is a condition that poses challenges in diagnosing Parkinson's disease (PD). We investigated tremor parameters in PD and ET patients with rest tremor...
  63. ncbi Visually guided movements suppress subthalamic oscillations in Parkinson's disease patients
    Ramin Amirnovin
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114 3117, USA
    J Neurosci 24:11302-6. 2004
    ..One possible explanation for these observations is that the increased cortical drive associated with movement preparation and execution leads to a transient dampening of STN oscillations, hence facilitating movement...
  64. doi Tremor modulation in patients with Parkinson's disease compared to healthy counterparts during loaded postural holding
    Ing Shiou Hwang
    Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    J Electromyogr Kinesiol 19:e520-8. 2009
    Through examining tremor dynamics, the study sought to investigate the effects of load characteristics upon control strategies in patients with Parkinson's disease (PD) during postural holding...
  65. pmc Spinal interneuron circuits reduce approximately 10-Hz movement discontinuities by phase cancellation
    Elizabeth R Williams
    Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
    Proc Natl Acad Sci U S A 107:11098-103. 2010
    b>Tremor imposes an important limit to the accuracy of fine movements in healthy individuals and can be a disabling feature of neurological disease...
  66. ncbi Stereotactic lesional surgery for the treatment of tremor in multiple sclerosis: a prospective case-controlled study
    S H Alusi
    Imperial College School of Medicine, North West London NHS Trust, Central Middlesex Hospital, Department of Clinical Neurology Institute of Neurology, London and University Department of Physiology, Oxford University, Oxford, UK
    Brain 124:1576-89. 2001
    The effect of stereotactic lesional surgery for the treatment of tremor in multiple sclerosis was examined in a prospective case-controlled study...
  67. ncbi Assessment of the amplitude of oscillations associated with high-frequency components of physiological tremor: impact of loading and signal differentiation
    Christian Duval
    Faculty of Applied Health Science, Brock University, 500 Glenridge Ave, St Catharines, Ontario, Canada
    Exp Brain Res 163:261-6. 2005
    The goal of this study was accurate quantification of the amplitude of high-frequency components of physiological tremor (PT) in units of displacement, velocity, and acceleration...
  68. doi Pharmacogenetics of parkinsonism, rigidity, rest tremor, and bradykinesia in African-Caribbean inpatients: differences in association with dopamine and serotonin receptors
    Asmar F Al Hadithy
    Department of Pharmacotherapy and Pharmaceutical Care, GUIDE, University of Groningen, Groningen, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:890-7. 2008
    ..serotonin 2(c) (HTR2C) receptors and Antipsychotic-Induced Parkinsonism (AIP), rigidity, bradykinesia, and rest-tremor in African-Caribbeans treated with antipsychotics...
  69. doi Computational physiology of the basal ganglia in Parkinson's disease
    Michal Rivlin-Etzion
    The Interdisciplinary Center for Neural Computation, The Hebrew University, Jerusalem, Israel
    Prog Brain Res 183:259-73. 2010
    ..The frequency of these oscillations is often similar to that of the parkinsonian tremor, but their role in generating the tremor or other parkinsonian symptoms is still under debate...
  70. pmc Moving toward "laboratory-supported" criteria for psychogenic tremor
    Petra Schwingenschuh
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, United Kingdom
    Mov Disord 26:2509-15. 2011
    A confident clinical diagnosis of psychogenic tremor is often possible, but, in some cases, a "laboratory-supported" level of certainty would aid in early positive diagnosis...
  71. ncbi Coupling between limb tremor and postural sway in Parkinson's disease
    Graham Kerr
    School of Human Movement Studies, Queensland University of Technology, Queensland, Australia
    Mov Disord 23:386-94. 2008
    Increased tremor and postural instability are motor problems commonly associated with Parkinson's disease (PD)...
  72. ncbi Anomalies of asymmetry of clinical signs in parkinsonism
    Cory Toth
    Division of Neurology, Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Mov Disord 19:151-7. 2004
    Parkinson's disease (PD) is characterized by a minimum of two of three features: tremor, rigidity, and bradykinesia. Asymmetry of these features is often considered to support a diagnosis of PD in contrast to other parkinsonian syndromes...
  73. pmc Neurological tremor: sensors, signal processing and emerging applications
    Giuliana Grimaldi
    FNRS, Neurologie ULB Erasme, 808 Route de Lennik, 1070 Bruxelles, Belgium
    Sensors (Basel) 10:1399-422. 2010
    Neurological tremor is the most common movement disorder, affecting more than 4% of elderly people. Tremor is a non linear and non stationary phenomenon, which is increasingly recognized...
  74. doi Analysis of fatigue and tremor during sustained maximal grip contractions using Hilbert-Huang Transformation
    Ke Li
    Institute of Biomedical Engineering, Shandong University, 73 Ave Jingshi, 250061 Jinan, China
    Med Eng Phys 34:832-40. 2012
    The objective of this study was to evaluate muscle fatigue and tremor during a Sustained Maximal Grip Contraction (SMGC) using the Hilbert-Huang Transformation (HHT)...
  75. ncbi EMG analysis of harmaline-induced tremor in normal and three strains of mutant mice with Purkinje cell degeneration and the role of the inferior olive
    T E Milner
    Departement de Physiologie, Universite de Montreal, Quebec, Canada
    J Neurophysiol 73:2568-77. 1995
    ..3 ml harmaline (10 mg/kg). Spectral analysis was used to quantify the amplitude and frequency of tremor found in the EMGs after harmaline administration...
  76. ncbi A force-plate actometer for quantitating rodent behaviors: illustrative data on locomotion, rotation, spatial patterning, stereotypies, and tremor
    S C Fowler
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS, USA
    J Neurosci Methods 107:107-24. 2001
    ..range of behaviors or behavioral attributes, such as locomotor activity, rotation around the center, whole-body tremor, and amphetamine-induced stereotypies. Spatial resolution is less than 1 mm, and temporal resolution is 0.02 s...
  77. ncbi Serotonin synthesis inhibition in olivo-cerebellar system attenuates harmaline-induced tremor in Swiss albino mice
    Hina Mehta
    Division of Neurosciences, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Jadavpur, Calcutta 700 032, India
    Behav Brain Res 145:31-6. 2003
    ..evidences point to the active role of central serotonin (5-HT) elicited mechanisms in the pathogenesis of tremor. The present study was undertaken to investigate the effects of p-chlorophenylalanine (pCPA), a specific ..
  78. ncbi The fragile X tremor ataxia syndrome in the differential diagnosis of multiple system atrophy: data from the EMSA Study Group
    C Kamm
    Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Hoppe Seyler Strasse 3, University of Tubingen, 72086 Tübingen, Germany
    Brain 128:1855-60. 2005
    The recent identification of fragile X-associated tremor ataxia syndrome (FXTAS) associated with premutations in the FMR1 gene and the possibility of clinical overlap with multiple system atrophy (MSA) has raised important questions, such ..
  79. pmc A 5-HT2A receptor inverse agonist, ACP-103, reduces tremor in a rat model and levodopa-induced dyskinesias in a monkey model
    Kimberly E Vanover
    ACADIA Pharmaceuticals Inc, San Diego, CA, USA
    Pharmacol Biochem Behav 90:540-4. 2008
    ..2:1, active:salt)], was evaluated for its ability to reduce the primary motor symptom of tremor using tacrine-induced tremulous jaw movements in rats, which is an animal model of parkinsonian tremor...
  80. pmc Oculopalatal tremor explained by a model of inferior olivary hypertrophy and cerebellar plasticity
    Aasef G Shaikh
    Department of Neurology, The Johns Hopkins University, Baltimore, MD 21287, USA
    Brain 133:923-40. 2010
    The inferior olivary nuclei clearly play a role in creating oculopalatal tremor, but the exact mechanism is unknown...
  81. doi The causal relationship between subcortical local field potential oscillations and Parkinsonian resting tremor
    Peter Tass
    Institute of Neuroscience and Medicine Neuromodulation INM 7 and Virtual Institute of Neuromodulation, Research Center Julich, D 52425 Julich, Germany
    J Neural Eng 7:16009. 2010
    To study the dynamical mechanism which generates Parkinsonian resting tremor, we apply coupling directionality analysis to local field potentials (LFP) and accelerometer signals recorded in an ensemble of 48 tremor epochs in four ..
  82. pmc Heterogeneity of Parkinson's disease in the early clinical stages using a data driven approach
    S J G Lewis
    Cambridge Centre for Brain Repair, Forvie Site, Addenbrooke s Hospital, Cambridge, CB2 2PY, UK
    J Neurol Neurosurg Psychiatry 76:343-8. 2005
    ..To investigate the heterogeneity of idiopathic Parkinson's disease (PD) in a data driven manner among a cohort of patients in the early clinical stages of the disease meeting established diagnostic criteria...
  83. ncbi Design and validation of a rehabilitation robotic exoskeleton for tremor assessment and suppression
    E Rocon
    Biomedical Engineering Group at Consejo Superior de Investigaciones Científicas, Madrid 28500, Spain
    IEEE Trans Neural Syst Rehabil Eng 15:367-78. 2007
    ..Upper limb robotic exoskeletons may be helpful for people with disabilities and/or limb weakness or injury. Tremor is the most common movement disorder in neurological practice...
  84. pmc The FMR1 gene and fragile X-associated tremor/ataxia syndrome
    J R Brouwer
    Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 150:782-98. 2009
    ..that elderly PM carriers might develop a progressive neurodegenerative disorder called fragile X-associated tremor/ataxia syndrome...
  85. doi The fragile X-associated tremor ataxia syndrome
    Flora Tassone
    University of California, Sacramento, CA, USA
    Results Probl Cell Differ 54:337-57. 2012
    Fragile X-associated tremor/ataxia syndrome (FXTAS) is an adult-onset neurodegenerative disorder clinically characterized by intention tremor and gait ataxia, in addition to other conditions including hypothyroidism, autonomic dysfunction,..
  86. ncbi Relationships between quantitative measures and neurologist's clinical rating of tremor and standing steadiness in two epidemiological studies
    F Gerr
    Rollins School of Public Health of Emory University, Atlanta, GA, USA
    Neurotoxicology 21:753-60. 2000
    ..present investigation was to 1) compare a neurologist's physical examination (NPx) rating of severity of postural tremor to several summary measures derived from quantitative measurements of tremor and 2) compare a NPx rating of ..
  87. ncbi Tremor in otosurgery: influence of physical strain on hand steadiness
    D Mürbe
    Department of Otorhinolaryngology, Medical Faculty, Technical University, Dresden, Germany
    Otol Neurotol 22:672-7. 2001
    ..Hand steadiness is mainly influenced by the tremor movements of the hand...
  88. pmc The management of tremor
    Peter G Bain
    Department of Neurosciences, Imperial College, London, UK
    J Neurol Neurosurg Psychiatry 72:I3-I9. 2002
  89. ncbi Intention tremor during manual aiming: a study of eye and hand movements
    P Feys
    Katholieke Universiteit Leuven, Department of Kinesiology, Motor Learning Laboratory, Belgium
    Mult Scler 9:44-54. 2003
    ..Intention tremor and eye movement deficits are frequently observed in multiple sclerosis (MS)...
  90. ncbi Effects of topiramate in patients with cerebellar tremor
    GianPietro Sechi
    Neurological Clinic, University of Sassari, Viale San Pietro 10, 07100 Sassari, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 27:1023-7. 2003
    To evaluate the safety and potential beneficial effect of topiramate (TPM) as monotherapy or adjunctive therapy to carbamazepine (CBZ) in patients with cerebellar tremor.
  91. ncbi Analysis of amplitude and frequency variations of essential and Parkinsonian tremors
    J B Gao
    Department of Electrical and Computer Engineering, University of Florida, USA
    Med Biol Eng Comput 42:345-9. 2004
    ..in frequency reflect the stable nature of the neural network that generates the rhythmicity responsible for the tremor. The variations in amplitude, however, reflect more the fluctuations in the firing of individual neurons in the ..
  92. pmc Long duration asymmetrical postural tremor is likely to predict development of Parkinson's disease and not essential tremor: clinical follow up study of 13 cases
    K Ray Chaudhuri
    Department of Neurology, King s College Hospital, Denmark Hill, London, SE5 9RS, UK
    J Neurol Neurosurg Psychiatry 76:115-7. 2005
    Patients presenting with asymmetrical postural tremor with or without mild rest tremor may be diagnosed as having essential tremor (ET), although there is considerable diagnostic uncertainty as to the long term outcome of these patients.
  93. ncbi Selective attenuation of afferent synaptic transmission as a mechanism of thalamic deep brain stimulation-induced tremor arrest
    Trent R Anderson
    Hotchkiss Brain Institute, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, T2N 4N1, Canada
    J Neurosci 26:841-50. 2006
    Deep brain stimulation (DBS) of the ventrolateral thalamus stops several forms of tremor. Microelectrode recordings in the human thalamus have revealed tremor cells that fire synchronous with electromyographic tremor...
  94. ncbi Head tremor in Parkinson's disease
    Emmanuel Roze
    Department of Neurology, Saint Antoine Hospital, Assistance Publique Hopitaux de Paris AP HP, Paris, France
    Mov Disord 21:1245-8. 2006
    Head tremor is a typical feature of essential tremor. Patients with sporadic Parkinson's disease can have tremor of the tongue, lip, or chin, but classically do not have head tremor...
  95. ncbi CGG repeat length correlates with age of onset of motor signs of the fragile X-associated tremor/ataxia syndrome (FXTAS)
    Flora Tassone
    Department of Biochemistry and Molecular Medicine, University of California, School of Medicine, Davis, California 95616, USA
    Am J Med Genet B Neuropsychiatr Genet 144:566-9. 2007
    Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurological disorder among carriers of premutation CGG-repeat expansions within the FMR1 gene...
  96. pmc Tremor varies as a function of the temporal regularity of deep brain stimulation
    Merrill J Birdno
    Biomedical Engineering, Duke University, Duke University Medical Center, Durham, North Carolina 27708 0281, USA
    Neuroreport 19:599-602. 2008
    ..is one of the primary factors determining the effectiveness of deep brain stimulation (DBS) in relieving tremor. DBS efficacy, however, may depend not only on the average frequency of stimulation, but also on the temporal ..
  97. pmc Essential tremor might be less frequent than Parkinson's disease in North Israel Arab villages
    Amir Glik
    Department of Neurology and The Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel
    Mov Disord 24:119-22. 2009
    Essential tremor (ET) is much more prevalent than Parkinson's disease (PD) in Western countries. We estimated ET and PD prevalence in Wadi Ara Arabic villages in Northern Israel...
  98. doi The amplitude of physiological tremor can be voluntarily modulated
    Benoit Carignan
    Département de kinanthropologie, Universite du Quebec a Montreal, 1205, rue St Denis, Montreal, QC, Canada
    Exp Brain Res 194:309-16. 2009
    The objective of this study was to determine whether it was possible to voluntarily modulate physiological tremor (PT), i.e., reduce its amplitude...
  99. doi The effect of supporting a surgeon's wrist on their hand tremor
    Chris J Coulson
    ENT Department, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK
    Microsurgery 30:565-8. 2010
    Operative tremor can greatly influence the outcome of certain, precise, microsurgical operations. Reducing a surgeons tremor may not only improve the operative results but decrease the operative time...
  100. doi Finger tremor can be voluntarily reduced during a tracking task
    Jean François Daneault
    Département de kinanthropologie, Universite du Quebec a Montreal, 141 Avenue du Président Kennedy, Montreal, Quebec, Canada
    Brain Res 1370:164-74. 2011
    IT is a well-known fact that physiological tremor has a deleterious effect on small and precise movements. We recently showed that the amplitude of postural physiological tremor can be voluntarily reduced...
  101. doi Postural sway during quiet standing is related to physiological tremor and muscle volume in young and elderly adults
    Motoki Kouzaki
    Laboratory of Neurophysiology, Graduate School of Human and Environmental Studies, Kyoto University, Yoshida nihonmatsu, Sakyo ku, Kyoto, Japan
    Gait Posture 35:11-7. 2012
    ..we investigated the association between postural sway during quiet standing and either amplitude of physiological tremor or muscle volume of the plantar flexors in 20 young and 20 elderly adults...

Research Grants83

  1. Exome re-sequencing candidate loci for familial essential tremor
    Barry E Kosofsky; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Essential tremor (ET) is one of the most common neurological disorders in humans with a prevalence reaching almost four percent...
  2. Donald M Kuhn; Fiscal Year: 2016
    ..The progressive loss of nigrostriatal DA neurons gradually leads to a severe movement disorder characterized by tremor, rigidity, bradykinesia and impaired balance...
  3. Laurie J Ozelius; Fiscal Year: 2016
    ..disorders characterized by twisting muscle contractures, with dystonia as the only clinical sign (except for tremor) and in the absence of neuronal degeneration or an acquired cause...
  4. The Ethics of Fragile X Genetic Screening and Testing Across the Lifespan
    Kruti Acharya; Fiscal Year: 2012
    ..Premutations cause premature ovarian failure and Fragile X Tremor Ataxia Syndrome in adults...
  5. Clinical center for the study of neuroprotection from PD
    Joseph Jankovic; Fiscal Year: 2013
    ..disorders, affecting approximately 1 million people in North America and is characterized clinically by resting tremor, cogwheel rigidity, bradykinesia and postural instability [Lang &Lozano, 1998]...
  6. Scheduled and Responsive Brain Stimulation for the Treatment of Tourette Syndrome
    Michael S Okun; Fiscal Year: 2010
    ..Although DBS has been utilized for addressing basal ganglia disorders such as Parkinson disease, essential tremor, and dystonia, these diseases differ fundamentally from TS...
  7. Susan M Rivera; Fiscal Year: 2016
    ..Furthermore, they are at risk for developing a neurodegenerative disease, fragile X-associated tremor ataxia syndrome (FXTAS), characterized by neurological manifestations of progressive gait ataxia, intention tremor,..
  8. Human iPSC neuronal models for early and late phases of FXTAS neurodegeneration
    Paul J Hagerman; Fiscal Year: 2010
    ..elucidation of the pathogenic mechanism of a leading single-gene neurodegenerative disorder, fragile X-associated tremor/ataxia syndrome (FXTAS), using human neuronal cells reprogrammed from patient fibroblasts through induced ..
  9. Effects on Caffeine on Adolescent Behavior and Physiology
    Jennifer L Temple; Fiscal Year: 2010
    ..Aim 1, a dose response study will be conducted by taking physiological (heart rate, blood pressure, and hand tremor) and psychological measurements in response to administration of placebo and three doses of caffeine...
  10. Matthew Klein; Fiscal Year: 2014
    ..Two recent studies suggest that Sam68 is involved in the pathogenesis of Fragile X Tremor/Ataxia Syndrome, and Spinal Muscular Atrophy...
  11. SCOTT MICHAEL WILSON; Fiscal Year: 2014
    ..Homozygous axJ mice, which are deficient for Usp14, display a resting tremor, hind limb rigidity, reduced muscle mass and die by 8 weeks of age...
  12. Michelle M McCarthy; Fiscal Year: 2016
    ..provided by applicant): Parkinson's disease is a chronic, disabling neurologic disorder causing resting tremor, muscular rigidity, bradykinesia and impairment of gait...
  13. Randy Strong; Fiscal Year: 2016
    ..population aged 65 - 85 years the clinical manifestations of PD include slowness of voluntary movement, resting tremor, muscle rigidity and postural instability...
  14. The Impact of Deep Brain Stimulation on Frontal-Subcortical Emotional Processing
    Joseph S Neimat; Fiscal Year: 2012
    ..motor scores and quality of life measures for patients suffering from Parkinson's disease, essential tremor and dystonia1-5...
  15. Prevalence of FMRI Expansions in Movement Disorders
    Deborah A Hall; Fiscal Year: 2010
    ..D. in Clinical Science. The candidate's immediate goals are to continue research in the fragile X-associated tremor/ataxia syndrome, by directly applying her newly acquired epidemiologic and biostatistics skills in the proposed ..
  16. SOREN YVETTE LOWELL; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Essential tremor is among the most common movement disorders, affecting nearly 5% of people over the age of 65...
  17. Thomas A Cooper; Fiscal Year: 2016
    ..of other microsatellite expansion disorders such as Spinocerebellar Ataxia 8 (SCA8), Fragile X-associated Tremor/Ataxia Syndrome (FXTAS), and Huntington Disease-Like 2 (HDL2)...
  18. Deborah A Hall; Fiscal Year: 2016
    ..associated with intellectual disability, autism, infertility, an neurodegenerative disorder in adults, to include tremor and gait ataxia...
  19. Peter K Todd; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Fragile X Tremor Ataxia Syndrome (FXTAS) is a common erited cause of gait disorder and tremor affecting upwards of 1:800 males...
  20. Randi J Hagerman; Fiscal Year: 2016
    ..and psychopathology in adulthood to neurodegeneration in aging;the latter includes the Fragile X-associated Tremor Ataxia Syndrome (FXTAS) that we have identified with our Australian collaborators...
  21. Synaptic regulation of single substantia nigra pars reticulata neurons
    STEVEN WILLIAM JOHNSON; Fiscal Year: 2012
    ..in the subthalamonigral pathway is thought to contribute to motor symptoms such as rigidity, bradykinesia and tremor. Preliminary data from our lab show that focal electrical stimulation of the STN evokes an initial monosynaptic ..
  22. Amplification Strategies for Detection of Fragile X Gene Trinucleotide Repeats
    Andrew G Hadd; Fiscal Year: 2011
    ..A more modest expansion of the CGG repeats is associated with Fragile X-associated Tremor/Ataxia Syndrome (FX-TAS) in older men and primary ovarian insufficiency (FX-POI) in women...
  23. Peter K Todd; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Objectives: Fragile X associated Tremor Ataxia Syndrome (FXTAS) is a common inherited neurodegenerative disorder characterized by dementia, gait disorder and tremor...
  24. The toxicity of the RNA CGG repeats in FXTAS
    Lubov T Timchenko; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) is a progressive neurodegenerative disease characterized by tremor with ataxia, brain atrophy and cognitive defects...
  25. David E Vaillancourt; Fiscal Year: 2016
    ..the Parkinsonian variant of multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and essential tremor (ET). Taken together, these movement disorders affect over 10 million people in the United States alone...
  26. Pontine motor circuits
    Jun Lu; Fiscal Year: 2013
    ..Parkinsonism includes resting tremor, rigidity, postural abnormalities, gait disturbances and bradykinesia/akinesia...
  27. Martin Paukert; Fiscal Year: 2014
    ..Withdrawal from ethanol unmasks these adaptations leading to severe tremor and other symptoms...
  28. Cortical and basal ganglia local field potentials in human movement disorders
    Philip A Starr; Fiscal Year: 2012
    ..ganglia disorder (PD and primary dystonia), with two comparison groups without basal ganglia pathology (essential tremor (ET) and epilepsy). Movement disorders patients are studied while undergoing awake placement of DBS electrodes...
  29. Robert F Berman; Fiscal Year: 2016
    ..and molecular targets for treating pathology in Fragile X premutation carriers (PM) and in Fragile X-associated tremor/ataxia (FXTAS) using CGG knock-in mice (CGGex KI) and doxycycline-inducible dox-CGG99 mice...
  30. Fatta B Nahab; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Essential Tremor (ET) is the most common tremor disorder, currently affecting an estimated 2.9 million Americans and leading to disability and decreased quality of life in 75% of cases...
  31. Kendall H Lee; Fiscal Year: 2015
    ..approach for a variety of neurological and psychiatric disorders including Parkinson's disease, essential tremor, epilepsy, and depression, among others...
  32. Jerrold L Vitek; Fiscal Year: 2016
    ..of PD and renewed the exploration of surgical therapy for a wide range of neurological disorders including tremor, dystonia, obsessive compulsive disorder, depression, Tourette syndrome, addiction, pain and epilepsy...
  33. GRETCHEN OLSON REYNOLDS; Fiscal Year: 2015
    ..It is predicted that the intervention will reduce anxiety and PD-specific symptoms, namely freezing and tremor, which may be exacerbated by anxiety...
  34. PET STUDY OF BIOCHEMISTRY AND METABOLISM OF THE CNS
    Kirk A Frey; Fiscal Year: 2012
    ..considerable progress has been made in understanding and treating the "typical" movement abnormalities of resting tremor, bradykinesia and rigidity...
  35. Abigail Renoux; Fiscal Year: 2014
    ..This is a model of the neurodegenerative disorder Fragile X-associated Tremor/Ataxia Syndrome (FXTAS), which is allelic with FXS...
  36. John L R Rubenstein; Fiscal Year: 2016
    ..Defects that alter sensorimotor learning can result in motor phenotypes, as exemplified by chorea, tremor and rigidity seen in disorders such as Huntington's disease and Parkinson's disease...
  37. Coro Paisan-Ruiz; Fiscal Year: 2016
    ..patients are affected by more than one movement disorder (such as parkinsonism and dystonia, or myoclonus and tremor), are a continuing challenge for diagnosis and treatment...
  38. Essential Tremor: Gene expression profiling in cerebellar Purkinje cells
    Phyllis L Faust; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Essential tremor (ET) is among the most common neurological diseases, occurring in 4% of adults age 40 and older, and even more frequently in advanced age (i.e., 7-8% by age 70 and >20% by age 90+)...
  39. DBS of the pedunculopontine nucleus in Parkinsonian primate
    Jerrold L Vitek; Fiscal Year: 2010
    ..has proven to be an effective therapy for the treatment of this disorder producing substantial improvements in tremor, bradykinesia, and rigidity, but has been less effective on improving gait and postural stability...
  40. Pharmacology of Connexin Channels: Structure-Activity Studies.
    Miduturu Srinivas; Fiscal Year: 2010
    ..and promising pharmacological targets in the treatment of epilepsy, cardiac arrhythmia, cancer, stroke, essential tremor, and in reducing the extent of cell death following ischemia...
  41. DAVID LOREN NELSON; Fiscal Year: 2016
    ..Fragile X-associated tremor/ataxia syndrome (FXTAS), a late age of onset neurodegenerative disorder, has been recognized in older males of ..
  42. Catherine L Gallagher; Fiscal Year: 2015
    ..Parkinson's disease (PD) is a common disease of aging that causes motor symptoms such as slow movement and tremor, as well as non-motor symptoms, such as cognitive decline...
  43. Aloke K Dutta; Fiscal Year: 2015
    ..The cardinal clinical features of PD include resting tremor, rigidity, difficulty initiating movement, and postural instability...
  44. Coro Paisan-Ruiz; Fiscal Year: 2014
    ..by applicant): The long-term goal of this proposal is to identify novel gene mutations underlying essential tremor (ET) to gain insights into its biology and etiology, which are poorly understood...
  45. Role of UCH-L1 Oxidative Modification in Parkinson's Disease Pathogenesis
    JEANNE ELIZABETH MCKEON; Fiscal Year: 2012
    ..neurodegenerative disorder affecting the motor system, and is characterized clinically by bradykinesia and resting tremor, and pathologically by dopaminergic neurodegeneration and intracellular Lewy body deposition...
  46. Novel MRI Methods for Neuronal Loss and Iron Quantification in Parkinsons Disease
    Shalom Michaeli; Fiscal Year: 2010
    ..Parkinson's disease (PD) is a neurodegenerative disorder characterized by slowness, stiffness and often tremor. Over 1 million Americans have PD and globally 9 million people are projected to have PD by the year 2030...
  47. ROMAN JENO GIGER; Fiscal Year: 2016
    ..mice with global loss of Fig4 expression (Fig4-/-) exhibit dramatic reduction of myelin in the CNS and PNS, severe tremor, and juvenile lethality...
  48. Andre Guelman Machado; Fiscal Year: 2014
    ..are already available and FDA approved for the treatment of patients with advanced Parkinson's disease and tremor. Hence translating this therapy for rats to humans will be simple...
  49. Neurocognitive Mechanisms of Inhibition Deficits in Parkinson's Disease
    Scott A Wylie; Fiscal Year: 2013
    ..g., bradykinesia, tremor). Of increasing concern are the effects of PD and its treatment on specific cognitive processes...
  50. Dopamine, mutant synuclein, oxidative stress and inflammation
    Howard J Federoff; Fiscal Year: 2010
    ..disease is a slowly progressive degenerative disorder with classic motor symptoms that include resting tremor, cogwheel rigidity and bradykinesia...
  51. Exercise training in Parkinson's disease: Neural and functional benefits
    Narayanan Krishnamurthi; Fiscal Year: 2010
    For individuals with Parkinson's disease (PD), symptoms such as tremor, rigidity, poor balance and difficulties in walking often limit their participation in physical activities...
  52. JOSEPH GIUFFRIDA; Fiscal Year: 2014
    ..PUBLIC HEALTH RELEVANCE: Parkinson's disease is primarily characterized by motor symptoms of tremor, bradykinesia (slowed movements), and rigidity which can be very debilitating, leading to decreased mobility, ..
  53. CHRISTOPHER LEE PULLIAM; Fiscal Year: 2014
    ..on in-clinic testing and/or the patient's subjective assessment of and ability to distinguish between PD tremor, dyskinesias, and voluntary movements throughout the day...
  54. Striatal Origin of Pathological Beta Oscillations in Parkinson's Disease
    Xue Han; Fiscal Year: 2013
    ..degeneration in the Substantia Nigra pars compacta (SNpc), resulting in cardinal motor dysfunctions: resting tremor, bradykinesia (slowness of voluntary movement), muscular rigidity, and gait instability...
  55. Kristina Simonyan; Fiscal Year: 2016
    ..SD becomes even more incapacitating when it is associated with action-induced voice tremor (VT) due to its poor response to gold standard treatment with botulinum toxin...
  56. Dopaminergic Modulation Of Cognitive Aspects Of Skill Acquisition In PD
    Brenda Hanna Pladdy; Fiscal Year: 2010
    Parkinson disease (PD) is characterized by cardinal symptoms of bradykinesia, rigidity, and resting tremor considered reflective of dopaminergic (DA) neuronal loss in the nigrostriatal tract...
  57. Randy M Bruno; Fiscal Year: 2016
    ..lead to abnormal flow of excitation between brain regions, potentially initiating or contributing to seizure- or tremor-like activity in neurological diseases...
  58. Apparatus for placing electrodes for deep-brain stimulation
    J Michael Fitzpatrick; Fiscal Year: 2012
    ..DBS is employed to treat movement disorders including tremor, rigidity, and drug-induced side effects in patients with Parkinson's disease and essential tremor, which ..
  59. Alberto J Espay; Fiscal Year: 2015
    ..resonance imaging (fMRI) to uncover specific abnormalities in emotional circuitry in patients with psychogenic tremor (PT), the most common forms of PMD;and will examine the therapeutic value of cognitive behavioral therapy (CBT) ..
  60. COLLIN JETHRO LOBB; Fiscal Year: 2014
    ..signs of the disease include muscular rigidity, bradykinesia, akinesia, shuffled and unstable gait, and resting tremor. Electrophysiological studies in Parkinsonian patients, 6-OHDA rats, and MPTP-treated, non- human primates have ..
  61. Arrays for deep brain microstimulation and recording
    DOUGLAS BUCHANAN MCCREERY; Fiscal Year: 2010
    ..structures (DBS) has developed into an effective treatment for advanced Parkinson's disease and essential tremor. DBS also is being evaluated as a treatment for other neurological conditions and appears to be useful in the ..
  62. Development of Novel Therapies for Levodopa-induced Dyskinesia in Parkinson's Dis
    Nurulain T Zaveri; Fiscal Year: 2010
    ..by degeneration of dopaminergic neurons in the brain, resulting in debilitating motor deficits such as tremor, rigidity, and akinesia, which have a severe impact on the patient as well as society...
  63. INVESTIGATION AND TREATMENT OF OCULAR MOTOR DISORDERS
    RICHARD JOHN LEIGH; Fiscal Year: 2012
    ..The third project aims to better understand a form of acquired nystagmus (oculopalatal tremor) that impairs vision...
  64. MOTOR FUNCTIONS AND FIBER CONNECTIONS OF PALLIDUM
    SAMUEL LILES; Fiscal Year: 1990
    ..movement abnormalities associated with Parkinsonism or Huntington's Disease, such as akinesia, rigidity, resting tremor, chorea, athetosis, as well as hemiballismus and a variety of drug-induced dyskinesia...
  65. Assessment of Brain Iron and Neuronal Integrity Using Novel T1r and T2r MRI
    Shalom Michaeli; Fiscal Year: 2009
    ..Parkinson's disease (PD) is a neurodegenerative disorder characterized by slowness, stiffness and often tremor. Over 1 million Americans have PD and globally 9 million people are projected to have PD by the year 2030...
  66. Influence of the Basal Ganglia on Cerebellar Action
    Alan Gibson; Fiscal Year: 2007
    ..Parkinson's disease, which affects about 1.5 million Americans, is a basal gangliar disease that leads to tremor, decreased spontaneous movement and slowness of voluntary movement...
  67. Functional Studies of Subtypes of Parkinson's Diseasee
    Xuemei Huang; Fiscal Year: 2007
    ..The clinical hallmarks of PD are tremor, muscle rigidity, bradykmesia, and postural instability; cognitive impairment related to frontal lobe dysfunction ..
  68. PERIANETHETIC TREMOR AND THERMOREGULATION
    Daniel Sessler; Fiscal Year: 1993
    ..Generalized postoperative tremor (which clinically resembles shivering) can also cause complications including an approximate 150% increase in ..
  69. HIGH FIELD MRI IN PARKINSONS DISEASE
    Jay Gorell; Fiscal Year: 1999
    ..devastating, common neurological disorder, producing slow, clumsy bodily movements, muscular rigidity and tremor, as well as impaired balance and cognition in many instances...
  70. Amplification Strategies for Detection of Fragile X Trinucleotide Repeats
    ANDREW HADD; Fiscal Year: 2009
    ..A more modest expansion of the CGG repeats is associated with Fragile X-associated Tremor/Ataxia Syndrome (FX-TAS) in older men and primary ovarian insufficiency (FX-POI) in women...
  71. Deep Brain Stimulation Array for Neuromodulation
    RIO VETTER; Fiscal Year: 2007
    ..DBS is currently approved for treatment of Parkinson's Disease (PD) and Essential Tremor and is showing promise for treatment of dystonia, intractable epilepsy, major depression, and obsessive-compulsive ..
  72. Force Plate Actometer for Measuring Behavior in Rodents
    Candice Kissinger; Fiscal Year: 2003
    ..actometer as an instrument to provide quantitative measurements of rodent behavior, including locomotor activity, tremor, rotational activity and amphetamine-induced focused stereotypies...
  73. GENETIC EPIDEMIOLOGY OF ESSENTIAL TREMOR
    Elan Louis; Fiscal Year: 1999
    Essential tremor (ET) is one of the most prevalent adult neurological disorders. Despite this, several fundamental clinical and genetic issues remain unknown: (1) The extent of familial aggregation is not known...
  74. MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONS
    Mark George; Fiscal Year: 2002
    ..DBS) of the thalamus, globus pallidus (GPi) or subthalamic nucleus (STN) is a new treatment for essential tremor and bradykinesia in Parkinson's Disease (PD)...
  75. Ethics of Control and Consent in Brain Stimulation for Parkinson Disease
    CYNTHIA M S KUBU; Fiscal Year: 2010
    ..Symptom control refers to one's ability to alter disease symptoms, such as tremor. Device control refers to one's ability to adjust the actual stimulator settings...
  76. Parkinson's Disease Neuroprotection Clinical Center
    Charles Adler; Fiscal Year: 2005
    ..All patients develop a gradually progressive combination of signs and symptoms, including tremor, rigidity, slowness of movement, drooling, low volume speech, micrographia, gait and balance difficulty, and ..
  77. Fragile X-associated Tremor/Ataxia Syndrome
    Paul Hagerman; Fiscal Year: 2009
    ..is the identification of the mechanistic basis for a progressive neurological disorder, fragile X-associated tremor/ataxia syndrome (FXTAS), which involves intention tremor, gait ataxia, and dementia, and affects at least 1/3 of ..
  78. CEREBELLOTHALAMIC SYSTEM--MOTOR AND COGNITIVE CIRCUITS
    Igor Ilinsky; Fiscal Year: 1999
    ..Traditionally, VL has been implicated in manifestations of movement disorders such as Parkinsonian tremor and rigidity, but the mechanisms of this involvement remain unclear...