psychomotor agitation

Summary

Summary: A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug toxicity or other conditions.

Top Publications

  1. ncbi Calming versus sedative effects of intramuscular olanzapine in agitated patients
    John Battaglia
    University of Wisconsin Medical School, Madison, WI, USA
    Am J Emerg Med 21:192-8. 2003
  2. ncbi Management of aggression, agitation, and psychosis in dementia: focus on atypical antipsychotics
    Peter Aupperle
    Division of Geriatric Psychiatry, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA
    Am J Alzheimers Dis Other Demen 21:101-8. 2006
  3. ncbi The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients
    Curtis N Sessler
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, Virginia 23298, USA
    Am J Respir Crit Care Med 166:1338-44. 2002
  4. ncbi Efficacy of nonpharmacologic interventions for agitation in advanced dementia: a randomized, placebo-controlled trial
    Jiska Cohen-Mansfield
    Department of Health Promotion, School of Public Health, Sackler Faculty of Medicine, and Herczeg Institute on Aging, Tel Aviv University, POB 39040, Ramat Aviv, Tel Aviv, 69978, Israel
    J Clin Psychiatry 73:1255-61. 2012
  5. ncbi Agitation in Dutch institutionalized patients with dementia: factor analysis of the Dutch version of the Cohen-Mansfield Agitation Inventory
    Sytse U Zuidema
    Department of Nursing Home Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Dement Geriatr Cogn Disord 23:35-41. 2007
  6. ncbi Opioid treatment for agitation in patients with advanced dementia
    Paolo L Manfredi
    The Jewish Home and Hospital, New York, USA
    Int J Geriatr Psychiatry 18:700-5. 2003
  7. ncbi Lavender oil as a treatment for agitated behaviour in severe dementia: a placebo controlled study
    Clive Holmes
    University of Southampton, School of Medicine, Community Clinical Sciences Research Division, Memory Assessment and Research Unit, Moorgreen Hospital, Southampton, UK
    Int J Geriatr Psychiatry 17:305-8. 2002
  8. ncbi Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery
    Berrin Isik
    Department of Anesthesiology and Reanimation, Gazi University Faculty of Medicine, Ankara, Turkey
    Paediatr Anaesth 16:748-53. 2006
  9. ncbi Effect of single-dose dexmedetomidine on emergence agitation and recovery profiles after sevoflurane anesthesia in pediatric ambulatory surgery
    Masami Sato
    Department of Anesthesia, Kyoto University Hospital, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Anesth 24:675-82. 2010
  10. ncbi Assessing neuropsychiatric symptoms in nursing home patients with dementia: reliability and Reliable Change Index of the Neuropsychiatric Inventory and the Cohen-Mansfield Agitation Inventory
    Sytse U Zuidema
    Department of Primary and Community Care, Centre for Family Medicine, Geriatric Care and Public Health, Radboud University Nijmegen, Medical Centre, Nijmegen, The Netherlands
    Int J Geriatr Psychiatry 26:127-34. 2011

Research Grants

  1. Behavioral Studies of Mental Retardation and Depression
    William McIlvane; Fiscal Year: 2007
  2. Rumination, arousal and cognition in depression: an fMRI/EEG study
    FRIDA POLLI; Fiscal Year: 2009
  3. ENGAGEMENT OF PERSONS WITH DEMENTIA
    Jiska Cohen Mansfield; Fiscal Year: 2006
  4. TREATMENT OF AGITATION IN THE NURSING HOME
    Jiska Cohen Mansfield; Fiscal Year: 2010
  5. Emergency Linkage to Outpatient Psychiatric Care
    Glenn Currier; Fiscal Year: 2007
  6. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
  7. TREATMENT OF BEHAVIORAL SYMPTOMS IN ALZHEIMERS DISEASE
    Davangere Devanand; Fiscal Year: 2001
  8. Antipsychotic Discontinuation in Alzheimer s Disease
    Davangere Devanand; Fiscal Year: 2008
  9. A PRESCRIPTION FOR ENHANCING RESIDENT QUALITY OF LIFE
    Ann Kolanowski; Fiscal Year: 2008
  10. MANAGEMENT FOR RISK OF RELAPSE IN SCHIZOPHRENIA
    Stephen Marder; Fiscal Year: 2004

Detail Information

Publications230 found, 100 shown here

  1. ncbi Calming versus sedative effects of intramuscular olanzapine in agitated patients
    John Battaglia
    University of Wisconsin Medical School, Madison, WI, USA
    Am J Emerg Med 21:192-8. 2003
    ....
  2. ncbi Management of aggression, agitation, and psychosis in dementia: focus on atypical antipsychotics
    Peter Aupperle
    Division of Geriatric Psychiatry, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA
    Am J Alzheimers Dis Other Demen 21:101-8. 2006
    ..For patients with severe BPSD such as psychosis, agitation, or aggression, for whom there are few options, atypical antipsychotics, particularly risperidone and olanzapine, should be considered...
  3. ncbi The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients
    Curtis N Sessler
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, Virginia 23298, USA
    Am J Respir Crit Care Med 166:1338-44. 2002
    ..Our nurses described RASS as logical, easy to administer, and readily recalled. RASS has high reliability and validity in medical and surgical, ventilated and nonventilated, and sedated and nonsedated adult ICU patients...
  4. ncbi Efficacy of nonpharmacologic interventions for agitation in advanced dementia: a randomized, placebo-controlled trial
    Jiska Cohen-Mansfield
    Department of Health Promotion, School of Public Health, Sackler Faculty of Medicine, and Herczeg Institute on Aging, Tel Aviv University, POB 39040, Ramat Aviv, Tel Aviv, 69978, Israel
    J Clin Psychiatry 73:1255-61. 2012
    ....
  5. ncbi Agitation in Dutch institutionalized patients with dementia: factor analysis of the Dutch version of the Cohen-Mansfield Agitation Inventory
    Sytse U Zuidema
    Department of Nursing Home Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Dement Geriatr Cogn Disord 23:35-41. 2007
    ..To establish the construct validity of the Dutch version of the Cohen-Mansfield Agitation Inventory (CMAI-D) in institutionalized patients with dementia...
  6. ncbi Opioid treatment for agitation in patients with advanced dementia
    Paolo L Manfredi
    The Jewish Home and Hospital, New York, USA
    Int J Geriatr Psychiatry 18:700-5. 2003
    ..We hypothesized that unrecognized pain could contribute to agitation and that low dose opioid therapy might reduce agitation by reducing pain. We therefore attempted to determine the effect of opioids on agitation in demented patients...
  7. ncbi Lavender oil as a treatment for agitated behaviour in severe dementia: a placebo controlled study
    Clive Holmes
    University of Southampton, School of Medicine, Community Clinical Sciences Research Division, Memory Assessment and Research Unit, Moorgreen Hospital, Southampton, UK
    Int J Geriatr Psychiatry 17:305-8. 2002
    ..To determine whether aromatherapy with lavender oil is effective in the treatment of agitated behaviour in patients with severe dementia...
  8. ncbi Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery
    Berrin Isik
    Department of Anesthesiology and Reanimation, Gazi University Faculty of Medicine, Ankara, Turkey
    Paediatr Anaesth 16:748-53. 2006
    ..The purpose of the present study was to determine whether prophylactic use of 1 microg x kg(-1) dexmedetomidine affected the incidence of emergence agitation (EA) after sevoflurane based anesthesia without surgery in children...
  9. ncbi Effect of single-dose dexmedetomidine on emergence agitation and recovery profiles after sevoflurane anesthesia in pediatric ambulatory surgery
    Masami Sato
    Department of Anesthesia, Kyoto University Hospital, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Anesth 24:675-82. 2010
    ..To study the effects of dexmedetomidine (DEX), a selective α(2)-adrenoreceptor agonist, on emergence agitation (EA), recovery profiles, and parents' satisfaction after sevoflurane anesthesia in pediatric ambulatory surgery...
  10. ncbi Assessing neuropsychiatric symptoms in nursing home patients with dementia: reliability and Reliable Change Index of the Neuropsychiatric Inventory and the Cohen-Mansfield Agitation Inventory
    Sytse U Zuidema
    Department of Primary and Community Care, Centre for Family Medicine, Geriatric Care and Public Health, Radboud University Nijmegen, Medical Centre, Nijmegen, The Netherlands
    Int J Geriatr Psychiatry 26:127-34. 2011
    ..Reliable Change methodology is a practical method for estimating the least change acquired in outcome measures...
  11. ncbi Dexmedetomidine reduces emergence agitation after tonsillectomy in children by sevoflurane anesthesia: a case-control study
    Qing tao Meng
    Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
    Int J Pediatr Otorhinolaryngol 76:1036-41. 2012
    ..To evaluate the efficacy and safety of dexmedetomidine for emergence agitation after tonsillectomy in children...
  12. ncbi Effect of acetaminophen on behavior, well-being, and psychotropic medication use in nursing home residents with moderate-to-severe dementia
    John T Chibnall
    Department of Psychiatry, School of Medicine, Saint Louis University, St Louis, Missouri 63104, USA
    J Am Geriatr Soc 53:1921-9. 2005
    ..To evaluate the effect of regularly scheduled administration of analgesic medication on behavior, emotional well-being, and use of as-needed psychotropic medications in nursing home residents with moderate-to-severe dementia...
  13. ncbi Double-blind, placebo-controlled comparison of intramuscular olanzapine and intramuscular haloperidol in the treatment of acute agitation in schizophrenia
    P Wright
    Lilly Research Centre, Eli Lilly Company, Surrey, UK
    Am J Psychiatry 158:1149-51. 2001
    ..No significant QT(c) interval changes were observed in any patients. CONCLUSIONS: Intramuscular olanzapine represents a rapid, effective, and safe treatment for acute agitation in schizophrenia...
  14. ncbi Severe agitation among ventilated medical intensive care unit patients: frequency, characteristics and outcomes
    Jeffery C Woods
    Critical Care and Step down Nursing, Huron Hospital, Cleveland, Ohio, USA
    Intensive Care Med 30:1066-72. 2004
    ..To determine the frequency, characteristics and outcomes of severe agitation among ventilated medical intensive care unit (MICU) patients...
  15. ncbi Dexmedetomidine infusion for analgesia and prevention of emergence agitation in children with obstructive sleep apnea syndrome undergoing tonsillectomy and adenoidectomy
    Anuradha Patel
    Associate Department of Anesthesiology and Perioperative Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Medical Science, Newark, NJ 07101, USA
    Anesth Analg 111:1004-10. 2010
    ..We compared an intraoperative dexmedetomidine infusion with bolus fentanyl to reduce perioperative opioid use and decrease emergence agitation in children with obstructive sleep apnea syndrome undergoing adenotonsillectomy (T&A)...
  16. ncbi Neuropsychiatric complications of traumatic brain injury: a critical review of the literature (a report by the ANPA Committee on Research)
    Edward Kim
    Bristol Myers Squibb Company, Neuroscience Medical Strategy, 777 Scudders Mill Road, Plainsboro, NJ 08536, USA
    J Neuropsychiatry Clin Neurosci 19:106-27. 2007
    ..Larger multicenter prospective studies using standardized diagnostic instruments are needed to further clarify the nosology, risk factors, and clinical course of these disorders. Specific directions for research are provided...
  17. ncbi Single-dose dexmedetomidine reduces agitation and provides smooth extubation after pediatric adenotonsillectomy
    Gulen Guler
    Department of Anesthesiology, Erciyes University, Medical Faculty, Kayseri, Turkey
    Paediatr Anaesth 15:762-6. 2005
    ..In this placebo-controlled study, we examined the effect of single dose dexmedetomidine on emergence agitation in children undergoing adenotonsillectomy...
  18. ncbi The expert consensus guideline series. Treatment of behavioral emergencies 2005
    Michael H Allen
    University of Colorado School of Medicine, USA
    J Psychiatr Pract 11:5-108; quiz 110-2. 2005
    ..We undertook a new survey of expert opinion to update recommendations from the earlier survey...
  19. ncbi Comparison of olanzapine and risperidone in the treatment of psychosis and associated behavioral disturbances in patients with dementia
    Walter G Deberdt
    Lilly Research Laboratories, Indianapolis, IN, USA
    Am J Geriatr Psychiatry 13:722-30. 2005
    ..The authors compared efficacy of olanzapine versus placebo and risperidone as measured by the Neuropsychiatric Inventory and Clinical Global Impression-Severity of Psychosis scale in patients with dementia-related psychosis...
  20. ncbi The effect of fentanyl on the emergence characteristics after desflurane or sevoflurane anesthesia in children
    Ira Todd Cohen
    Department of Anesthesiology, Children s National Medical Center, Washington, DC 20010, USA
    Anesth Analg 94:1178-81, table of contents. 2002
    ..In children receiving desflurane or sevoflurane, the concurrent use of fentanyl in a dose of 2.5 microg/kg results in a small incidence of emergence agitation...
  21. ncbi Venlafaxine-propafenone interaction resulting in hallucinations and psychomotor agitation
    Pietro Gareri
    Faculty of Medicine and Surgery, University Magna Graecia of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini University Hospital, Operative Unit Elderly Health Care, Catanzaro, Italy
    Ann Pharmacother 42:434-8. 2008
    To report a case of visual hallucinations and psychomotor agitation probably induced by an interaction between venlafaxine and propafenone.
  22. ncbi Calming music and hand massage with agitated elderly
    Ruth Remington
    University of Massachusetts, Lowell 01854, USA
    Nurs Res 51:317-23. 2002
    ..Agitated behavior is a widespread problem that adversely affects the health of nursing home residents and increases the cost of their care...
  23. ncbi Olanzapine orally disintegrating tablet vs. risperidone oral solution in the treatment of acutely agitated psychotic patients
    Kotaro Hatta
    Department of Psychiatry, Juntendo University School of Medicine, Bunkyo ku, Tokyo 113 8421, Japan
    Gen Hosp Psychiatry 30:367-71. 2008
    ..Efficacy and tolerability of risperidone oral solution (RIS-OS) and olanzapine orally disintegrating tablet (OLZ-ODT) were compared for the treatment of acute psychotic agitation...
  24. ncbi Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa
    Clive G Ballard
    Wolfson Research Centre, Newcastle General Hospital, Institute for Ageing and Health, Newcastle upon Tyne, United Kingdom
    J Clin Psychiatry 63:553-8. 2002
    ..We conducted a placebo-controlled trial to determine the value of aromatherapy with essential oil of Melissa officinalis (lemon balm) for agitation in people with severe dementia...
  25. ncbi How reliable is the Bispectral Index in critically ill patients? A prospective, comparative, single-blinded observer study
    Stanley A Nasraway SA
    Department of Surgery, New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Crit Care Med 30:1483-7. 2002
    ..To establish a correlation between a reliable subjective measure, the Sedation-Agitation Scale (SAS), and an objective tool, the Bispectral Index (BIS), for monitoring critically ill patients with a decreased level of consciousness...
  26. ncbi Efficacy of aromatherapy (Lavandula angustifolia) as an intervention for agitated behaviours in Chinese older persons with dementia: a cross-over randomized trial
    Pamela Wan ki Lin
    Department of Occupational Therapy, Castle Peak Hospital, and Department of Psychiatry, Chinese University of Hong Kong, Hong Kong
    Int J Geriatr Psychiatry 22:405-10. 2007
    ..As pharmacological interventions may be limited by their potentially adverse effects, the use of complementary therapies for treatment of agitation has become more popular and aromatherapy is the fastest growing one...
  27. ncbi Adaptation to the Intensive Care Environment (ATICE): development and validation of a new sedation assessment instrument
    Bernard De Jonghe
    Centre Hospitalier de Poissy Saint Germain, France
    Crit Care Med 31:2344-54. 2003
    ..To develop a valid, reliable, and responsive bedside instrument assessing Adaptation to the Intensive Care Environment (ATICE) in mechanically ventilated adult intensive care unit (ICU) patients...
  28. pmc Prevalence and clinical significance of subsyndromal manic symptoms, including irritability and psychomotor agitation, during bipolar major depressive episodes
    Lewis L Judd
    National Institute of Mental Health Collaborative Program on the Psychobiology of Depression, Clinical Studies, USA
    J Affect Disord 138:440-8. 2012
    ..This paper examines the prevalence and clinical characteristics of MDEs with subsyndromal manic symptoms. The specific effects of overt irritability and psychomotor agitation are examined.
  29. ncbi Consequences of aggressive behavior in patients with dementia
    Mark E Kunik
    Houston Center for Quality of Care and Utilization Studies, Houston, TX 77030, USA
    J Neuropsychiatry Clin Neurosci 22:40-7. 2010
    ..Of 215 patients, 88 became aggressive, associated with significantly increased use of psychotropic medication (p< or =0.04), injuries (p< or =0.0001), and nursing-home placement (p< or =0.004)...
  30. ncbi Emergence agitation in children undergoing adenotonsillectomy: a comparison of sevoflurane vs. sevoflurane-remifentanil administration
    H S Na
    Department of Anaesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam si, Gyeonggi Do, South Korea
    Acta Anaesthesiol Scand 57:100-5. 2013
    ..Sevoflurane is widely used in paediatric anaesthesia but frequently causes emergence agitation (EA). This study evaluated whether limiting the sevoflurane concentration by combining remifentanil with sevoflurane reduced the incidence of EA...
  31. ncbi Managing the agitated psychotic patient: a reappraisal of the evidence
    M H Allen
    Department of Behavioral Health, Denver Health Medical Center, University of Colorado School of Medicine, USA
    J Clin Psychiatry 61:11-20. 2000
    ..Issues of diagnosis, relative efficacy, dosage, route, onset, offset, safety, tolerability, and consumer preference are considered...
  32. ncbi Management of agitation and aggression associated with Alzheimer's disease: controversies and possible solutions
    Clive Ballard
    Wolfson Centre for Age Related Diseases, King s College London, London, UK
    Curr Opin Psychiatry 22:532-40. 2009
    ..The purpose of this review is to describe the current state of knowledge regarding management of BPSD, with a particular focus on agitation...
  33. ncbi Aromatherapy and behaviour disturbances in dementia: a randomized controlled trial
    J Smallwood
    Psychology Department, The University of Strathclyde, Glasgow, UK
    Int J Geriatr Psychiatry 16:1010-3. 2001
    ..05). This provides preliminary evidence of a measurable sedative effect of aromatherapy massage on dementia within a robust scientific paradigm. Further research is recommended with an expanded sample size...
  34. ncbi Risperidone liquid concentrate and oral lorazepam versus intramuscular haloperidol and intramuscular lorazepam for treatment of psychotic agitation
    G W Currier
    Department of Psychiatry, University of Rochester, NY 14642, USA
    J Clin Psychiatry 62:153-7. 2001
    ....
  35. ncbi A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease
    Alistair Burns
    Mental Health and Neurodegeneration, Age Psychiatry, University of Manchester, Manchester, UK
    Dement Geriatr Cogn Disord 31:158-64. 2011
    ....
  36. ncbi Using the Minimum Data Set to determine predictors of terminal restlessness among nursing home residents
    Feng Ping Lee
    Department of Nursing, Fooyin University
    J Nurs Res 14:286-96. 2006
    ..How to access residents' moods and provide appropriate and immediate interventions, comfort, and even just being there for them are imperative for nursing home care providers...
  37. ncbi A longitudinal examination of agitation and resident characteristics in the nursing home
    Louis D Burgio
    Center for Mental Health and Aging, Box 870315, University of Alabama, Tuscaloosa, AL 35487 0315, USA
    Gerontologist 47:642-9. 2007
    ..This study used cross-sectional and longitudinal (up to 18 months) methods to examine agitation among profoundly and moderately impaired residents using both staff report and direct observation methods...
  38. ncbi Psychomotor symptoms in depression: a diagnostic, pathophysiological and therapeutic tool
    Didier Schrijvers
    Collaborative Antwerp Psychiatric Research Institute, University of Antwerp, Universiteitsplein 1 B 2610 Antwerp, Belgium
    J Affect Disord 109:1-20. 2008
    ..In the current review of the recent literature, we aim to argue the importance of psychomotor symptoms in depression and propose directions for future research...
  39. ncbi Nonpharmacological treatment of agitation: a controlled trial of systematic individualized intervention
    Jiska Cohen-Mansfield
    Research Institute on Aging of the Charles E Smith Life Communities, 6121 Montrose Road, Rockville, MD 20852, USA
    J Gerontol A Biol Sci Med Sci 62:908-16. 2007
    ..The objective of this study was to examine the efficacy of a systematic algorithm for providing individualized, nonpharmacological interventions for reducing agitated behaviors in nursing home residents with dementia...
  40. ncbi Prevalence of neuropsychiatric symptoms in a large sample of Dutch nursing home patients with dementia
    Sytse U Zuidema
    Kalorama, Beek Ubbergen, The Netherlands
    Int J Geriatr Psychiatry 22:632-8. 2007
    ..To estimate the prevalence of neuropsychiatric symptoms of dementia patients in Dutch nursing homes...
  41. ncbi Pharmacological management of acute agitation
    John Battaglia
    Department of Psychiatry and Behavioural Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Drugs 65:1207-22. 2005
    ..These intramuscular atypical antipsychotics may represent a historical advance in the treatment of acute agitation...
  42. ncbi A single dose of propofol at the end of surgery for the prevention of emergence agitation in children undergoing strabismus surgery during sevoflurane anesthesia
    Marie T Aouad
    Department of Anesthesiology, American University of Beirut, Medical Center, Lebanon
    Anesthesiology 107:733-8. 2007
    ..The authors compared the incidence and severity of emergence agitation in children who received a single dose of propofol at the end of strabismus surgery versus children who received saline...
  43. ncbi The effect of caudal analgesia on emergence agitation in children after sevoflurane versus halothane anesthesia
    B Craig Weldon
    Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida 32610 0254, USA
    Anesth Analg 98:321-6, table of contents. 2004
    ..Emergence agitation appears to be an early and transient phenomenon after sevoflurane anesthesia in children with effective postoperative analgesia...
  44. ncbi Strong association of the rest-activity rhythm with well-being in demented elderly women
    S Sandra Carvalho-Bos
    Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Am J Geriatr Psychiatry 15:92-100. 2007
    ..The objective of this study is to investigate the association between actigraphic estimates of the sleep-wake rhythm and a range of functional domains that contribute to well-being in demented elderly patients...
  45. ncbi Management of patients presenting with acute psychotic episodes of schizophrenia
    Pierre Thomas
    Department of Psychiatry, University of Lille Medical School, Lille, France
    CNS Drugs 23:193-212. 2009
    ..The long-term goal should be to minimize the risk of psychotic relapse through adequate treatment adherence...
  46. ncbi Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients
    Eric B Milbrandt
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Crit Care Med 33:226-9; discussion 263-5. 2005
    ..To determine whether haloperidol use is associated with lower mortality in mechanically ventilated patients...
  47. ncbi The Mahoney Pain Scale: examining pain and agitation in advanced dementia
    Alison E J Mahoney
    Department of Psychology, Centre for Emotional Health, Macquarie University, Sydney, Australia
    Am J Alzheimers Dis Other Demen 23:250-61. 2008
    ..The clinical impressions of nurses who trialed the tool were favorable; they reported that it seemed accurate and easy to use. Thus, the Mahoney Pain Scale may be useful for assessing pain in dementia...
  48. ncbi The association between intravenous haloperidol and prolonged QT interval
    K Hatta
    Department of Psychiatry, Tokyo Metropolitan Bokuto General Hospital, Japan
    J Clin Psychopharmacol 21:257-61. 2001
    ..Therefore, clinicians should be aware of the association between intravenous HAL and QT prolongation...
  49. ncbi Dangerous wandering: elopements of older adults with dementia from long-term care facilities
    Myra A Aud
    Sinclair School of Nursing, University of Missouri Columbia, Columbia, Missouri, USA
    Am J Alzheimers Dis Other Demen 19:361-8. 2004
    ....
  50. ncbi A pilot, open-label safety study of quetiapine for treatment of moderate psychotic agitation in the emergency setting
    Glenn W Currier
    University of Rochester Medical Center, 300 Crittenden Boulevard, Rochester, NY 14642, USA
    J Psychiatr Pract 12:223-8. 2006
    ..The goal of this pilot study was primarily to explore the safety and, secondarily, the efficacy of the use of "prn" quetiapine for treatment of moderate agitation accompanied by psychosis in an emergency department setting...
  51. pmc Current practices in managing acutely disturbed patients at three hospitals in Rio de Janeiro-Brazil: a prevalence study
    Gisele Huf
    Ministry of Health, Brazil
    BMC Psychiatry 2:4. 2002
    ..In order to prepare for a randomised trial, due to start in the psychiatric emergency rooms of Rio de Janeiro in 2001, a survey of current practice was necessary...
  52. ncbi Factor analysis of the Cohen-Mansfield Agitation Inventory in three large samples of nursing home patients with dementia and behavioral disturbance
    Jonathan Rabinowitz
    Bar Ilan University, Ramat Gan, Israel
    Am J Geriatr Psychiatry 13:991-8. 2005
    ..The authors tested the CMAI factor structure by use of data from three samples of nursing home patients categorized a priori as having at least mild behavioral and psychological symptoms of dementia...
  53. ncbi Effectiveness of gabapentin for the treatment of behavioral disorders in dementia
    N Herrmann
    Division of Geriatric Psychiatry, University of Toronto, Ontario, Canada
    J Clin Psychopharmacol 20:90-3. 2000
    ..Gabapentin may have a role in treating a subgroup of dementia patients with severe behavioral disorders who have not responded to neuroleptics...
  54. ncbi Validation of a Clinical Global Impression Scale for Aggression (CGI-A) in a sample of 558 psychiatric patients
    Christian G Huber
    Psychosis Early Detection and Intervention Centre, Centre for Psychosocial Medicine, Department of Psychiatry and Psychotherapy, University Medical Centre Hamburg Eppendorf, Germany
    Schizophr Res 100:342-8. 2008
    ..Clinical management of aggression depends on the availability of easily administrable measurements allowing reliable evaluation. The present study's aim is to validate a Clinical Global Impression-Severity of Aggression scale (CGI-A)...
  55. ncbi Verbal and physical non-aggressive agitated behaviors in elderly persons with dementia: robustness of syndromes
    Jiska Cohen-Mansfield
    Research Institute on Aging of the Hebrew Home of Greater Washington, Washington D C, USA
    J Psychiatr Res 39:325-32. 2005
    ..The present study was conducted to examine the robustness of two major syndromes, verbal agitation and physical non-aggressive agitation, as assessed via direct observations...
  56. ncbi Agitation and depression in frail nursing home elderly patients with dementia: treatment characteristics and service use
    Stephen J Bartels
    Aging Services Research, New Hampshire Dartmouth Psychiatric Research Center, Department of Psychiatry, Dartmouth Medical School, Lebanon, NH 03766, USA
    Am J Geriatr Psychiatry 11:231-8. 2003
    ..The authors describe characteristics, treatment, and acute service use associated with agitation and depression in dementia...
  57. ncbi [Anticonvulsant mood stabilizers in the treatment of behavioral and psychological symptoms of dementia (BPSD)]
    D Pinheiro
    Service de Psychiatrie Adulte, Centre Hospitalier Sainte Marie, route de Montredon, B P 21, 43001 Le Puy en Velay cedex, France
    Encephale 34:409-15. 2008
    ....
  58. ncbi Managing the acutely agitated and psychotic patient
    Kimberly Nordstrom
    Colorado West Regional Mental Health and Yampa Valley Medical Center, Denver, CO, USA
    CNS Spectr 12:5-11. 2007
    ....
  59. ncbi A naturalistic multicenter study of intramuscular olanzapine in the treatment of acutely agitated manic or schizophrenic patients
    L San
    Hospital San Rafael, Passeig Vall d Hebron, 107 117, 08035 Barcelona, Spain
    Eur Psychiatry 21:539-43. 2006
    ..The data thus obtained was compared with that reported from randomized double-blind clinical trials...
  60. ncbi Retrospective analysis of psychomotor agitation, hypomanic symptoms, and suicidal ideation in unipolar depression
    Paolo Olgiati
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Depress Anxiety 23:389-97. 2006
    In bipolar depression, psychomotor agitation is relatively common and often is associated with other noneuphoric hypomanic symptoms and suicidal ideation...
  61. pmc Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial
    Michael C Reade
    Department of Intensive Care Medicine, Austin Hospital and the University of Melbourne, 145 Studley Road, Heidelberg, Victoria 3084, Australia
    Crit Care 13:R75. 2009
    ..Dexmedetomidine, a novel sedative and anxiolytic agent, may have particular utility in these patients. We sought to compare the efficacy of haloperidol and dexmedetomidine in facilitating extubation...
  62. ncbi Dexmedetomidine to facilitate drug withdrawal
    Gerald A Maccioli
    Critical Health Systems, Inc, Raleigh, North Carolina, USA
    Anesthesiology 98:575-7. 2003
  63. pmc Tackling agitated delirium--the tip of the iceberg
    Valerie J Page
    Department of Anaesthetics, Watford General Hospital, Vicarage Road, Watford, WD19 4DZ, UK
    Crit Care 13:158. 2009
    ..Further research is needed into the pharmacological management of delirium, including the use of dexmedetomidine in the management of agitation and the clinical efficacy of haloperidol...
  64. ncbi Predictors of need-driven behaviors in nursing home residents with dementia and associated certified nursing assistant burden
    Misti J Norton
    Department of Psychology, The University of Alabama, Box 870348, Tuscaloosa, AL 35487 0348, USA
    Aging Ment Health 14:303-9. 2010
    ..American Journal of Alzheimer's Disease, 5, 10-19] were examined as potential predictors of need-driven behaviors (NDBs) and resistiveness to care and CNA burden...
  65. ncbi Antecedents, descriptions and consequences of wandering in cognitively-impaired adults and the Safe Return (SR) program
    M A Rowe
    University of Florida College of Nursing and Institute on Aging, Gainesville, USA
    Am J Alzheimers Dis Other Demen 16:344-52. 2001
    ..Recommendations are provided for communities to develop strategies to minimize unattended wandering and to determine effective methods of locating CI individuals when they become lost...
  66. ncbi Brief psychosocial therapy for the treatment of agitation in Alzheimer disease (the CALM-AD trial)
    Clive Ballard
    Wolfson Centre for Age Related Diseases, King s College London, Guy s Campus, London SE1 1UL, UK
    Am J Geriatr Psychiatry 17:726-33. 2009
    ..Good practice guidelines state that a psychological intervention should usually precede pharmacotherapy, but there are no data evaluating the feasibility of psychological interventions used in this way...
  67. ncbi A double-blind, placebo-controlled dose-response comparison of intramuscular olanzapine and haloperidol in the treatment of acute agitation in schizophrenia
    Alan Breier
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, DC 1748, Indianapolis, IN 46285, USA
    Arch Gen Psychiatry 59:441-8. 2002
    ..An intramuscular (IM) formulation of olanzapine has been developed because there are no rapid-acting IM atypical antipsychotic drugs currently available in the United States for treating acute agitation in patients with schizophrenia...
  68. ncbi Agitated "unipolar" depression re-conceptualized as a depressive mixed state: implications for the antidepressant-suicide controversy
    Hagop S Akiskal
    Department of Psychiatry and International Mood Center, University of California, La Jolla, CA, USA
    J Affect Disord 85:245-58. 2005
    ..S., Mallya, G., 1987. Criteria for the "soft" bipolar spectrum: treatment implications. Psychopharmacol Bull. 23, 68-73]...
  69. ncbi Management of agitation in the intensive care unit
    Mark D Siegel
    Pulmonary and Critical Care Section, Yale University School of Medicine, Medical Intensive Care Unit, Yale New Haven Hospital, New Haven, CT, USA
    Clin Chest Med 24:713-25. 2003
    ..In turn, the reward for excellent care will be shorter lengths of stay, more rapid liberation from mechanical ventilation, improved cognition, cost savings, and, perhaps, improved survival...
  70. ncbi Feasibility of dexmedetomidine in facilitating extubation in the intensive care unit
    P A Arpino
    Department of Pharmacy, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Pharm Ther 33:25-30. 2008
    ..Adding dexmedetomidine (dex), a potent alpha-2-adrenergic receptor agonist that possesses sedative, anxiolytic and analgesic effects without causing significant respiratory depression, may facilitate extubation in these patients...
  71. ncbi A randomized placebo-controlled trial of risperidone for the treatment of aggression, agitation, and psychosis of dementia
    Henry Brodaty
    Academic Department for Old Age Psychiatry, School of Psychiatry, University of New South Wales, Sydney, Australia
    J Clin Psychiatry 64:134-43. 2003
    ..This randomized, double-blind, placebo-controlled trial examined the efficacy and safety of risperidone in the treatment of aggression, agitation, and psychosis in elderly nursing-home patients with dementia...
  72. ncbi Motor Activity Assessment Scale: a valid and reliable sedation scale for use with mechanically ventilated patients in an adult surgical intensive care unit
    J W Devlin
    Department of Pharmacy Services, Henry Ford Hospital, Detroit, MI, USA
    Crit Care Med 27:1271-5. 1999
    ..To establish the validity and reliability of a new sedation scale, the Motor Activity Assessment Scale (MAAS)...
  73. ncbi Comparison of rapidly acting intramuscular olanzapine, lorazepam, and placebo: a double-blind, randomized study in acutely agitated patients with dementia
    Karena M Meehan
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Neuropsychopharmacology 26:494-504. 2002
    ..Intramuscular injection of olanzapine may therefore provide substantial benefit in rapidly treating inpatients with acute dementia-related agitation...
  74. ncbi Impact of systematic evaluation of pain and agitation in an intensive care unit
    Gerald Chanques
    Intensive Care and Anesthesiology Department B DAR B, Saint Eloi Hospital, Montpellier University Hospital, Montpellier Cedex 5, France
    Crit Care Med 34:1691-9. 2006
    ....
  75. ncbi The management of inappropriate vocalisation in dementia: a hierarchical approach
    Sue Barton
    Old Age Psychiatry, Royal Cornhill Hospital, Aberdeen, Scotland, UK
    Int J Geriatr Psychiatry 20:1180-6. 2005
    ..Inappropriate vocalisation is notoriously difficult to treat and clinicians may have to rely on a "trial and error" approach when attempting to limit the distress it causes...
  76. pmc Clinical review: agitation and delirium in the critically ill--significance and management
    Jean Claude Chevrolet
    Hopital Cantonal Universitaire, Rue Micheli du Crest, CH 1211 Geneva 4, Switzerland
    Crit Care 11:214. 2007
    ..Excellent tools are presently available for this purpose. Treatment, including prevention, must be undertaken without delay, and the ICU physician should follow logical, strict and systematic rules when applying therapy...
  77. ncbi Factors associated with the use of physical restraints for agitated patients in psychiatric emergency rooms
    Marcelo N Migon
    Department of Mental Health, Duque de Caxias General Hospital, Duque de Caxias, Rio de Janeiro, Brazil
    Gen Hosp Psychiatry 30:263-8. 2008
    ..To examine factors associated with physical restraint in psychiatric emergency rooms...
  78. ncbi Temporal patterns of disruptive vocalization in elderly nursing home residents
    L D Burgio
    Applied Gerontology Program, Department of Psychology, School of Social Work, University of Alabama at Tuscaloosa, Rm 210 Osband, Box 870315, Tuscaloosa, AL 35487-0315, USA
    Int J Geriatr Psychiatry 16:378-86. 2001
    ..The results are discussed in relation to these methodological issues and clinical implications of the findings...
  79. ncbi The efficacy of divalproex sodium in the treatment of agitation associated with major depression
    Charles DeBattista
    Depression Research Clinic, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    J Clin Psychopharmacol 25:476-9. 2005
    ..Thus, agitation merits investigation as a treatment target in clinical depression...
  80. ncbi Effectiveness of rapid initial dose escalation of up to forty milligrams per day of oral olanzapine in acute agitation
    Robert W Baker
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285
    J Clin Psychopharmacol 23:342-8. 2003
    ..Rapid assessment and effective treatment are necessary to manage agitation and, potentially, to shorten the time to recovery...
  81. ncbi Treatment of psychomotor agitation and self-injurious behavior with estrogen and progesterone in a patient with Sanfilippo syndrome
    Steven A Kushner
    Gen Hosp Psychiatry 27:298-300. 2005
  82. ncbi A prospective study of agitation in a medical-surgical ICU: incidence, risk factors, and outcomes
    Samir Jaber
    Intensive Care Unit and Transplantation, Department of Anesthesiology, DAR B, Hospital Saint Eloi, University of Montpellier, Montpellier Cedex 5, France
    Chest 128:2749-57. 2005
    ..Although agitation is thought to be common in the ICU, it has been poorly studied. We evaluated the incidence, risks factors, and outcomes of agitation in ICU...
  83. ncbi Agitation in nursing home residents: the role of gender and social context
    L D Burgio
    School of Social Work and Department of Psychology, University of Alabama at Tuscaloosa, 35487 0315, USA
    Int Psychogeriatr 12:495-511. 2000
    ..Results suggest that staff touch and verbal interaction elicit agitation in a significant proportion of residents. Once agitation occurs, staff were likely to respond by interacting verbally, but not physically, with the resident...
  84. ncbi Quetiapine to treat agitation in dementia: a randomized, double-blind, placebo-controlled study
    Kate X Zhong
    1800 Concord Pike, Wilmington, DE 19850 5437, USA
    Curr Alzheimer Res 4:81-93. 2007
    ..However, caution should be exercised given the concerns regarding increased mortality with atypical antipsychotics in this vulnerable patient population...
  85. ncbi [Patients in a state of agitation at the admission service of a Rouen hospital emergency department]
    F Moritz
    Service d Accueil et d Urgences Adulte, Hopital Charles Nicolle, CHU Rouen
    Presse Med 28:1630-4. 1999
    ..To determine the incidence and causes of agitation states in patients presenting at the Rouen University Hospital emergency room and to analyze the management scheme...
  86. ncbi Evaluation of three aggression/agitation behaviour rating scales for use on an acute admission and assessment psychogeriatric ward
    A Shah
    Imperial College School of Medicine, London, UK
    Int J Geriatr Psychiatry 13:415-20. 1998
    ..In recent years many instruments measuring aggressive and agitated behaviours among the elderly in a variety of settings have emerged. Individual instruments have only occasionally been compared with each other...
  87. ncbi Duration of risperidone treatment for BPSD
    John Snowdon
    Int J Geriatr Psychiatry 21:699-701. 2006
  88. pmc Elderly patients with dementia-related symptoms of severe agitation and aggression: consensus statement on treatment options, clinical trials methodology, and policy
    Carl Salzman
    Department of Psychiatry, Harvard Medical School, Boston, Mass 02115, USA
    J Clin Psychiatry 69:889-98. 2008
    ..In 2005, the FDA issued a black box warning regarding increased risk of mortality associated with the use of atypical antipsychotic drugs in this patient population...
  89. ncbi Agitation and psychosis in dementia
    Clive Ballard
    Am J Geriatr Psychiatry 15:913-7. 2007
  90. pmc Clinical symptom responses to atypical antipsychotic medications in Alzheimer's disease: phase 1 outcomes from the CATIE-AD effectiveness trial
    David L Sultzer
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    Am J Psychiatry 165:844-54. 2008
    ..The study measured the effects of atypical antipsychotics on psychiatric and behavioral symptoms in patients with Alzheimer's disease and psychosis or agitated behavior...
  91. ncbi Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the evidence
    Kathleen N Franco
    Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA
    J Am Med Dir Assoc 7:201-2. 2006
    ....
  92. pmc Effect of enhanced psychosocial care on antipsychotic use in nursing home residents with severe dementia: cluster randomised trial
    Jane Fossey
    Oxford University and Oxford Mental Healthcare Trust, Oxford
    BMJ 332:756-61. 2006
    ..To evaluate the effectiveness of a training and support intervention for nursing home staff in reducing the proportion of residents with dementia who are prescribed neuroleptics...
  93. ncbi Injectable atypical antipsychotics for agitation in borderline personality disorder
    J C Pascual
    Pharmacopsychiatry 39:117-8. 2006
    ..Twenty agitated BPD patients were treated with intramuscular atypical antipsychotics (olanzapine or ziprasidone). Results suggest intramuscular atypical antipsychotics may be effective, fast and safe for treating acute BPD patients...
  94. ncbi Comparative efficacy of risperidone versus haloperidol on behavioural and psychological symptoms of dementia
    Guk Hee Suh
    Department of Psychiatry, Hallym University Medical Center, Hangang Sacred Heart Hospital, Seoul, Korea
    Int J Geriatr Psychiatry 21:654-60. 2006
    ..Behavioural and psychological symptoms of dementia (BPSD) cannot be regarded as a single clinical syndrome, but rather as a heterogeneous group of symptoms, each of which can be considered as possible targets for therapy...
  95. ncbi [New formulations of olanzapine in the treatment of acute agitation]
    György Bartkó
    Jahn Ferenc Dél pesti Psychiatric Hospital, Budapest, Hungary
    Neuropsychopharmacol Hung 8:171-8. 2006
    ..Evidence suggests that the new formulations of olanzapine should be among the first-line choices in the treatment of agitation in acute psychosis...
  96. ncbi Quetiapine treatment of psychosis associated with dementia: a double-blind, randomized, placebo-controlled clinical trial
    Pierre N Tariot
    Memory Disorders Center, Banner Alzheimer s Disease Institute, Phoenix, Arizona, USA
    Am J Geriatr Psychiatry 14:767-76. 2006
    ....
  97. ncbi Treatment of agitation and aggression in bipolar mania: efficacy of quetiapine
    Peter F Buckley
    Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Affect Disord 100:S33-43. 2007
    ..Agitation and aggression are potentially disruptive and dangerous features of bipolar mania. This analysis evaluated the effects of quetiapine on agitation and aggression in patients with bipolar I mania...
  98. ncbi Aripiprazole for the treatment of psychoses in institutionalized patients with Alzheimer dementia: a multicenter, randomized, double-blind, placebo-controlled assessment of three fixed doses
    Jacobo E Mintzer
    Alzheimer s Research and Clinical Programs, Medical University of South Carolina, North Charleston, SC 29406 6076, USA
    Am J Geriatr Psychiatry 15:918-31. 2007
    ..To assess the efficacy and safety of aripiprazole for psychosis associated with Alzheimer dementia (AD)...
  99. ncbi Quetiapine for agitation or psychosis in patients with dementia and parkinsonism
    Roger Kurlan
    Mt Hope Professional Building, Rochester, NY 14620, USA
    Neurology 68:1356-63. 2007
    ..To assess the efficacy and tolerability of quetiapine for agitation or psychosis in patients with dementia and parkinsonism...
  100. ncbi Neither atypical nor conventional antipsychotics increase mortality or hospital admissions among elderly patients with dementia: a two-year prospective study
    Minna M Raivio
    Memory Research and Treatment Centers Finland Medical Center Hemo Oy, Lahti, Finland
    Am J Geriatr Psychiatry 15:416-24. 2007
    ..Antipsychotics are widely used to manage behavioral disorders in patients with dementia. Recently, serious concerns have been raised about the stroke and mortality risk of atypical antipsychotics when administered to patients with dementia...
  101. ncbi To prescribe or not to prescribe? Atypical antipsychotic drugs in patients with dementia
    Dilip V Jeste
    Department of Psychiatry University of California, San Diego VA San Diego Healthcare System San Diego, CA 92161, USA
    South Med J 100:961-3. 2007

Research Grants69

  1. Behavioral Studies of Mental Retardation and Depression
    William McIlvane; Fiscal Year: 2007
    ..Certain hallmarks of depression (changes in body weight, sleep problems, psychomotor agitation, etc.) can be detected readily via behavioral observation techniques. However, other hallmarks (e.g...
  2. Rumination, arousal and cognition in depression: an fMRI/EEG study
    FRIDA POLLI; Fiscal Year: 2009
    ..is dysregulated in depression, manifested in clinical symptoms such as diminished interest, fatigue, psychomotor agitation/retardation, and insomnia/hypersomnia, and will result in abnormal psychophysiological and neural ..
  3. ENGAGEMENT OF PERSONS WITH DEMENTIA
    Jiska Cohen Mansfield; Fiscal Year: 2006
    ..In that way, it presents an exciting prospect for improving the quality of life in demented persons, thereby reducing their caregivers' burden. ..
  4. TREATMENT OF AGITATION IN THE NURSING HOME
    Jiska Cohen Mansfield; Fiscal Year: 2010
    ..PHS 398 (Rev. 05/01) Page 2 Principal Investigator/Program Director (Last, first, middle): Cohen-Mansfield, Jiska ..
  5. Emergency Linkage to Outpatient Psychiatric Care
    Glenn Currier; Fiscal Year: 2007
    ..abstract_text> ..
  6. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  7. TREATMENT OF BEHAVIORAL SYMPTOMS IN ALZHEIMERS DISEASE
    Davangere Devanand; Fiscal Year: 2001
    ..These clinical data will be important in improving the management of AD patients with behavioral complications. ..
  8. Antipsychotic Discontinuation in Alzheimer s Disease
    Davangere Devanand; Fiscal Year: 2008
    ..The results will be of considerable value to the practicing clinician and have substantial implications for the regulatory oversight of elder care. ..
  9. A PRESCRIPTION FOR ENHANCING RESIDENT QUALITY OF LIFE
    Ann Kolanowski; Fiscal Year: 2008
    ..This study holds promise for improving quality of life for nursing home residents with dementia by using theoretically based activities to respond to their needs. ..
  10. MANAGEMENT FOR RISK OF RELAPSE IN SCHIZOPHRENIA
    Stephen Marder; Fiscal Year: 2004
    ..The investigator will evaluate outcome during the next two years with measures of clinical psychopathology, medication side effects, functional outcomes, and quality of life. ..
  11. TREATMENT OF NEGATIVE SYMPTOMS & COGNITIVE IMPAIRMENTS
    Stephen Marder; Fiscal Year: 2003
    ..The study will provide new information on the efficacy of d- cycloserine and glycine for both persistent primary and secondary negative symptoms and its effect on cognitive functioning. ..
  12. Depressoin in Alzheimer's Disease Study-2 (DIADS-2)
    Jacobo Mintzer; Fiscal Year: 2007
    ..abstract_text> ..
  13. Depression in Alzheimer's Disease Study 2 (DIADS-2)
    Lon Schneider; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  14. Apathy in Alzheimer's Disease Methylphenidate Trial
    Paul B Rosenberg; Fiscal Year: 2010
    ..This study aims to develop a new treatment for apathy in AD that could decrease its debilitating consequences and reduce patients'dependency on caregivers, providing well-deserved relief to patients and their loved ones. ..
  15. Institute for Research Minority Training on Mental Health
    Jacobo Mintzer; Fiscal Year: 2007
    ..We expect this effort to be the incubator for a new generation of minority researchers dedicated to the study mental health and aging. ..
  16. Progestrone and the Effects of Nicotine
    Mehmet Sofuoglu; Fiscal Year: 2006
    ..By characterizing the progesterone effects on nicotine dependence, this study may provide a better understanding of the mechanisms which mediate the sex and menstrual cycle phase effects on nicotine dependence. ..
  17. Rehabilitation and Health Care for Older Adults with SMI
    Stephen Bartels; Fiscal Year: 2005
    ..abstract_text> ..
  18. ADHD: Detection and Service Use
    Regina Bussing; Fiscal Year: 2008
    ..The research team has an extensive track record of success with similar study designs and will use innovative technologies to adhere to an efficient management plan. ..
  19. Metabolic Effects of Newer Antipsychotics in Older Pts
    Dilip Jeste; Fiscal Year: 2009
    ..abstract_text> ..
  20. GABA Medications for Tobacco Addiction
    Mehmet Sofuoglu; Fiscal Year: 2009
    ..The findings of this study will provide valuable information to develop new pharmacotherapies for smoking cessation. ..
  21. A Novel Animal Model of Relevance to Schizophrenia
    David Feifel; Fiscal Year: 2009
    ..The successful development of this animal model could significantly enhance the understanding of the underlying causes of schizophrenia-associated abnormalities and improve drug discovery. ..
  22. Treating Insomnia & Nightmares After Trauma: Impact on Symptoms & Quality of Life
    Sean P A Drummond; Fiscal Year: 2010
    ..This study will examine whether treatments specifically targeted at those sleep disorders can improve clinical outcomes and increase health- related quality of life in individuals recently exposed to war-related trauma. ..
  23. Can Longitudinal Population-Based Data Help to Personalize Depression Treatment?
    Gregory E Simon; Fiscal Year: 2010
    ..We propose a set of targeted methodologic studies to prepare for a multi-site research consortium focused on predicting response to specific depression treatments. ..
  24. Natural History of Attempts to Stop Smoking
    John R Hughes; Fiscal Year: 2010
    ....
  25. Exercise & Health Promotion for MCI: A Controlled Trial
    Linda Teri; Fiscal Year: 2010
    ..These older adults are at increased risk of developing Alzheimer's disease within 3 years, and delaying or preventing cognitive decline will preserve their ability to live independently and save public health dollars. ..
  26. NEUROBIOLOGY OF PAIN
    Tony Yaksh; Fiscal Year: 2005
    ..The complexity of the problems and the diversity of the training approaches emphasize that the training received by these fellows will provide a broad base of knowledge relevant to wide areas of neurobiology. ..
  27. MENTAL DISORDERS AS RISK FACTORS FOR SUBSTANCE DISORDERS
    Ronald Kessler; Fiscal Year: 2003
    ....
  28. POPULATION-BASED MANAGEMENT OF DEPRESSION
    Gregory Simon; Fiscal Year: 2003
    ..e. 12-18 mos) Incremental cost and cost-effectiveness of each intervention program compared to care as usual. ..
  29. Adult Outcome of Attention Deficit Hyperactivity Disorder
    Joseph Biederman; Fiscal Year: 2007
    ..For these reasons, we expect the proposed work to clarify the course and outcome of ADHD. ..
  30. EVALUATION OF A CIGARETTE SUBSTITUTE
    John Hughes; Fiscal Year: 2001
    ..We believe it imperative to begin studying these substitutes so that, unlike low-tar/low nicotine cigarettes, we will know whether their introduction is good or bad for public health. ..
  31. PANDAS and Strep Infection: Are they Linked?
    Roger Kurlan; Fiscal Year: 2004
    ..Disproving the PANDAS hypothesis would prevent the use of expensive and potentially dangerous therapies (e.g., plasma exchange, immune globulin, antibiotics) that have been proposed for PANDAS patients. ..
  32. PROSPECTIVE STUDY OF TARDIVE DYSKINESIA DEVELOPMENT
    John Kane; Fiscal Year: 2001
    ..This strategy will provide a rapid and cost-effective answer to a critical question. ..
  33. PROBING DRUG RELATED MENTAL DISORDERS OF AGING
    Ira Katz; Fiscal Year: 2003
    ..We will also explore the impact of medications on daily reports of positive or negative events and on the relationship between daily events and daily affect. ..
  34. Child Psychopathology and Risk for Drug Use Disorders
    NAOMI MARMORSTEIN; Fiscal Year: 2004
    ..These hypotheses will be examined using survival analyses, odds ratios, logistic regression, and hierarchical linear modeling; the correlated nature of the twin data used in this study will be statistically controlled. ..
  35. DEPRESSION/DESIRE FOR DEATH IN TERMINAL CANCER PATIENTS
    William Breitbart; Fiscal Year: 2003
    ..This study is expected to provide a direct evaluation of desire for death in terminally ill cancer patients, and to ascertain whether a pharmacological treatment for depression influences desire for death. ..
  36. Promoting Health & Functioning in Persons with SMI
    Stephen Bartels; Fiscal Year: 2008
    ..If found to be effective, ISL will provide a practical approach to improving health, independent functioning, and longevity in disabled persons with SMI. [unreadable] [unreadable] [unreadable]..
  37. PREVENTION OF SUICIDE IN THE ELDERLY
    Ira Katz; Fiscal Year: 2002
    ..Data will also be collected to document the impact of intervention on patient care, and on physician knowledge, attitudes, and satisfaction and test hypotheses derived from preliminary studies of the three IRCs. ..
  38. Sedation Effects in Mechanically Ventilated Patients
    Mary Jo Grap; Fiscal Year: 2009
    ..abstract_text> ..
  39. ADHD Symptoms in Autism: Cognition, Behavior, Treatment
    Deborah Pearson; Fiscal Year: 2009
    ..Thus, the primary goals of the proposed research are to characterize ADHD in school-aged children with Autistic Disorder (DSM-IV), and to assess their cognitive and behavioral response to MPH. ..
  40. Risk Factors for Psychopathology in the WHO WMH Surveys
    Ronald Kessler; Fiscal Year: 2009
    ..Third, the level of detail in the description of data analysis plans has been substantially expanded in this revised submission in response to reviewer comments. ..
  41. MANAGEMENT OF SLEEP-ACTIVITY DISRUPTION IN ALZHEIMERS
    Glenna Dowling; Fiscal Year: 2001
    ..Differences will be determined in the main effects between groups, main effects within groups over time, and the interaction between group and time. Post-hoc contrasts (Tukey) will be performed as needed. ..
  42. Cocaine Withdrawal and Pharmacotherapy Response
    Mehmet Sofuoglu; Fiscal Year: 2010
    ..This proposal, by testing the efficacy of carvedilol and investigating the influence of withdrawal severity on carvedilol's efficacy, may result in development of more effective treatments for cocaine addiction. ..
  43. Quantifying Children's Emotions with the Emotion Intensity-Linkage Function Model
    Michael Potegal; Fiscal Year: 2010
    ....
  44. Cognitive Sequelae of early and mid-life depression
    Hochang Lee; Fiscal Year: 2008
    ..This award will provide groundwork for his long term goal of becoming an expert in clinical epidemiology of late life mental disorders. ..
  45. UAMS Alzheimer's Disease Core Center
    Cornelia Beck; Fiscal Year: 2005
    ..abstract_text> ..
  46. FATIGUE, SLEEP AND CIRCADIAN RHYTHMS IN BREAST CANCER
    Sonia Ancoli Israel; Fiscal Year: 2004
    ..Results will provide a scientific basis for future intervention studies, particularly studies with light therapy which can re-synchronize rhythms. ..
  47. Depression, Cytokines, and Pancreatic Cancer
    William Breitbart; Fiscal Year: 2006
    ..abstract_text> ..
  48. RAT INTESTINAL MEMBRANE--VITAMIN D-MEDIATED EFFECTS
    Michael Sitrin; Fiscal Year: 2001
    ..Accordingly the specific aims of the proposal are to characterize the mechanisms involved in inhibition of cellular proliferation in CaCo-2 cells and the actions of the secosteroids in inducing apoptosis. ..
  49. A PROSPECTIVE STUDY OF THE DEVELOPMENT OF ADHD AND ODD
    Elizabeth Harvey; Fiscal Year: 2004
    ..abstract_text> ..
  50. Antipsychotic-Like Drug Effects of Neurotensin
    David Feifel; Fiscal Year: 2004
    ....
  51. Pain Assessment in Cognitively Impaired Children
    Shobha Malviya; Fiscal Year: 2005
    ..A reliable and valid pain assessment tool is critical to facilitate our future study of pain management strategies in these children. ..
  52. DVD Consent for Research in Older Schizophrenia Patients
    Dilip Jeste; Fiscal Year: 2008
    ..The DVD-based consent is not intended to supplant, but rather to supplement, the researcher-participant in-person interaction involved in consent process. ..
  53. Treating Mildly Cognitive- Impaired Depressed Elderly
    Gregory Pelton; Fiscal Year: 2005
    ....
  54. Improving Affect & Behavior in Assisted Living Residents
    Linda Teri; Fiscal Year: 2006
    ..Finally, the results of this trial will be used to develop a multi-site effectiveness trial on treatment to reduce affective and behavioral disturbance in AL residents with dementia. ..
  55. Epidemiology and Care of Comorbid Obesity and Depression
    Gregory Simon; Fiscal Year: 2006
    ..weight loss, nutrient intake, physical activity, depressive symptoms, functional impairment and disability in the two groups of women with comorbid obesity and depression randomly assigned to the two different intervention programs ..
  56. COMPARING THREE ELECTRODE PLACEMENTS TO OPTIMIZE ECT
    Keith Rasmussen; Fiscal Year: 2005
    ..The results of this study will promote more effective and safer treatment of the most severely ill depressed patients. ..
  57. Meaning-Centered Psychotherapy in Advanced Cancer
    William Breitbart; Fiscal Year: 2002
    ..Larger, randomized controlled trials of Meaning-Centered Group Psychotherapy will be conducted in the future utilizing the insights learned from this pilot intervention study. ..
  58. LATE ONSET SCHIZOPHRENIA--A NEUROPSYCHIATRIC STUDY
    Dilip Jeste; Fiscal Year: 2002
    ..g., MRI quantitative analysis, outcome and functioning measures) to the new questions being asked. Our studies should have a major impact on the understanding of schizophrenia and aging. ..
  59. WANDERING-- BACKROUND AND PROXIMAL FACTORS
    Donna Algase; Fiscal Year: 2003
    ..abstract_text> ..
  60. Novel Rehabilitative Approaches for Recovery from TBI
    ANTHONY KLINE; Fiscal Year: 2008
    ..Our long-term goal is to develop therapies that facilitate functional recovery after human TBI. ..
  61. Restless Legs risk in the biracial East Baltimore cohort
    Hochang Lee; Fiscal Year: 2006
    ..The value of these data analyses will be enhanced by the independent, blinded confirmation of the RLS screening questions (in approximately 20% of all subjects) using a validated diagnostic interview. ..
  62. NEUROLEPTIC-INDUCED MOVEMENT DISORDERS IN OLDER PATIENTS
    Dilip Jeste; Fiscal Year: 2003
    ..We believe that our findings will have major therapeutic implications for the use of antipsychotics, particularly in older patients. ..
  63. Cognitive Sequelae of Methamphetamine Abuse
    Ruth Salo; Fiscal Year: 2005
    ..abstract_text> ..
  64. Neural Correlates of Methamphetamine Use in Schizophrenia: An MRS Study
    Ruth Salo; Fiscal Year: 2007
    ..These findings will have important implications for neurobiological models of comorbid substance abuse and treatment. [unreadable] [unreadable] [unreadable]..
  65. Interaction of Serotonin & Cholinergic Systems After TBI
    ANTHONY KLINE; Fiscal Year: 2004
    ..The long-term goal is to develop pharmacotherapies that attenuate posttraumatic neuronal cell death and facilitate cognitive performance after human TBI. ..