hyperkinesis

Summary

Summary: Excessive movement of muscles of the body as a whole, which may be associated with organic or psychological disorders.

Top Publications

  1. pmc Drosophila tao controls mushroom body development and ethanol-stimulated behavior through par-1
    Ian King
    Department of Anatomy, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 31:1139-48. 2011
  2. ncbi Interactions between child behavior patterns and parenting: implications for children's unintentional injury risk
    David C Schwebel
    Department of Psychology, University of Alabama at Birmingham, 1300 University Boulevard, CH 415, Birmingham, AL 35294, USA
    J Pediatr Psychol 29:93-104. 2004
  3. ncbi Mouse model of hyperkinesis implicates SNAP-25 in behavioral regulation
    E J Hess
    Department of Neuroscience and Anatomy, The Pennsylvania State University College of Medicine, Hershey Medical Center, 17033, USA
    J Neurosci 16:3104-11. 1996
  4. ncbi Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity
    R R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Science 283:397-401. 1999
  5. pmc Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis
    Andras Garami
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurosci 31:1721-33. 2011
  6. ncbi Effects of physostigmine on the conditioned hyperactivity and locomotor sensitization to morphine in rats
    Xinwang Li
    Department of Psychology, Capital Normal University, Beijing, China
    Behav Brain Res 206:223-8. 2010
  7. ncbi Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor
    T Miyakawa
    Department of Pharmacology and Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, Tennessee 37205, USA
    J Neurosci 21:5239-50. 2001
  8. ncbi Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes
    F Xavier Castellanos
    New York University Child Study Center, 577 First Avenue, CSC 204, New York, New York 10016 6404, USA
    Nat Rev Neurosci 3:617-28. 2002
  9. ncbi Heat makes a difference in activity-based anorexia: a translational approach to treatment development in anorexia nervosa
    Maria Cerrato
    Departamento de Psicologia Clinica y Psicobiologia, Facultad de Psicologia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
    Int J Eat Disord 45:26-35. 2012
  10. ncbi Reduction of BDNF expression in Fmr1 knockout mice worsens cognitive deficits but improves hyperactivity and sensorimotor deficits
    M Uutela
    Institute of Biomedicine, Physiology, University of Helsinki, Finland
    Genes Brain Behav 11:513-23. 2012

Detail Information

Publications241 found, 100 shown here

  1. pmc Drosophila tao controls mushroom body development and ethanol-stimulated behavior through par-1
    Ian King
    Department of Anatomy, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 31:1139-48. 2011
    ....
  2. ncbi Interactions between child behavior patterns and parenting: implications for children's unintentional injury risk
    David C Schwebel
    Department of Psychology, University of Alabama at Birmingham, 1300 University Boulevard, CH 415, Birmingham, AL 35294, USA
    J Pediatr Psychol 29:93-104. 2004
    ..Along with hypotheses to replicate previous univariate effects, it was hypothesized that active, involved parents with sufficient time resources might reduce injury risk among temperamentally at-risk children...
  3. ncbi Mouse model of hyperkinesis implicates SNAP-25 in behavioral regulation
    E J Hess
    Department of Neuroscience and Anatomy, The Pennsylvania State University College of Medicine, Hershey Medical Center, 17033, USA
    J Neurosci 16:3104-11. 1996
    Although hyperkinesis is expressed in several neurological disorders, the biological basis of this phenotype is unknown...
  4. ncbi Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity
    R R Gainetdinov
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Science 283:397-401. 1999
    ..The parallels between the DAT knockout mice and individuals with ADHD suggest that common mechanisms may underlie some of their behaviors and responses to psychostimulants...
  5. pmc Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis
    Andras Garami
    Systemic Inflammation Laboratory, Trauma Research, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurosci 31:1721-33. 2011
    ..overweight and includes hypometabolism, enhanced skin vasoconstriction, decreased thermopreferendum, and hyperkinesis. The latter may be one of the primary deficiencies in Trpv1 KO mice...
  6. ncbi Effects of physostigmine on the conditioned hyperactivity and locomotor sensitization to morphine in rats
    Xinwang Li
    Department of Psychology, Capital Normal University, Beijing, China
    Behav Brain Res 206:223-8. 2010
    ..Physostigmine attenuates the expressions but enhances the development of conditioned hyperactivity and sensitization and the possible mechanisms are discussed...
  7. ncbi Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor
    T Miyakawa
    Department of Pharmacology and Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, Tennessee 37205, USA
    J Neurosci 21:5239-50. 2001
    ..Our results indicate that M(1) muscarinic receptors play an important role in the regulation of locomotor activity but appear to be less critical for cognitive processes, as generally assumed...
  8. ncbi Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes
    F Xavier Castellanos
    New York University Child Study Center, 577 First Avenue, CSC 204, New York, New York 10016 6404, USA
    Nat Rev Neurosci 3:617-28. 2002
  9. ncbi Heat makes a difference in activity-based anorexia: a translational approach to treatment development in anorexia nervosa
    Maria Cerrato
    Departamento de Psicologia Clinica y Psicobiologia, Facultad de Psicologia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
    Int J Eat Disord 45:26-35. 2012
    ..To test the effect of raising ambient temperature (AT) on activity-based anorexia (ABA) and to extend to female rats previous findings reported in male animals...
  10. ncbi Reduction of BDNF expression in Fmr1 knockout mice worsens cognitive deficits but improves hyperactivity and sensorimotor deficits
    M Uutela
    Institute of Biomedicine, Physiology, University of Helsinki, Finland
    Genes Brain Behav 11:513-23. 2012
    ..Our results show that the absence of FMRP modifies the diverse effects of BDNF on the FXS phenotype...
  11. ncbi The hyperactive syndrome: metanalysis of genetic alterations, pharmacological treatments and brain lesions which increase locomotor activity
    Davide Viggiano
    Department of Health Sciences, Faculty of Scienze del Benessere, University of Molise, Via De Sanctis III Edificio Polifunzionale, 86100 Campobasso, Italy
    Behav Brain Res 194:1-14. 2008
    ..We suggest that the increased locomotor activity in many psychiatric diseases may derive from the interference with the development of this brain axis during a specific postnatal time window...
  12. ncbi Rodent models of attention-deficit/hyperactivity disorder
    Terje Sagvolden
    Center for Advanced Study at the Norwegian Academy of Science and Letters, Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Biol Psychiatry 57:1239-47. 2005
    ....
  13. pmc Up-regulation of calcyon results in locomotor hyperactivity and reduced anxiety in mice
    Heather Trantham-Davidson
    Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA
    Behav Brain Res 189:244-9. 2008
    ....
  14. pmc Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration
    Nicolas Maubourguet
    Unité Neurobiologie Intégrative des Systèmes Cholinergiques, Institut Pasteur, Paris, France
    PLoS Comput Biol 4:e1000229. 2008
    ....
  15. ncbi Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists
    R J Ralph
    Departments of Neuroscience and Psychiatry, University of California San Diego, La Jolla, California 92093 0804, USA
    J Neurosci 21:305-13. 2001
    ..Furthermore, D1 receptor activation appears to be the critical substrate for the expression of preservative patterns of motor behavior, whereas both D1 and D2 receptors appear to regulate the amount of motor activity...
  16. ncbi Increased phencyclidine-induced hyperactivity following cortical cholinergic denervation
    Anna Mattsson
    Department of Neuroscience, Retzius Laboratory, Karolinska Institute, Stockholm, Sweden
    Neuroreport 16:1815-9. 2005
    ..These results suggest that aberrations in cholinergic function might lead to glutamatergic dysfunctions, which might be of relevance for the pathophysiology for schizophrenia...
  17. ncbi Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania
    Jos Prickaerts
    Division of Psychiatry, Johnson and Johnson Pharmaceutical Research and Development, B 2340 Beerse, Belgium
    J Neurosci 26:9022-9. 2006
    ..The behavioral observations led to the suggestion that the model at hand recapitulates hyperactivity as observed in the manic phase of bipolar disorder...
  18. pmc Attention deficits and hyperactivity following inhibition of cAMP-dependent protein kinase within the medial prefrontal cortex of rats
    Tracie A Paine
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 34:2143-55. 2009
    ..These studies indicate that PKA inhibition within the mPFC of rats produces inattention and hyperactivity, and thus might be useful in modeling human attention disorders...
  19. ncbi Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro
    Stephane Doly
    INSERM, U839 and Université Pierre et Marie Curie Paris 6, Institut du Fer a Moulin, Unité Mixte de Recherche S0839, Paris 75005, France
    J Neurosci 28:2933-40. 2008
    ..e., modulation of 5-HT release. As such, 5-HT(2B) receptor antagonists may serve as promising therapeutic drugs for MDMA abuse...
  20. ncbi Valproate attenuates hyperactive and perseverative behaviors in mutant mice with a dysregulated dopamine system
    Rebecca J Ralph-Williams
    Alcohol and Drug Abuse Research Center, Harvard Medical School and McLean Hospital, Belmont, Massachusetts, USA
    Biol Psychiatry 53:352-9. 2003
    ..We hypothesized that the DAT KD mice would also display deficits in prepulse inhibition (PPI) and would be perseverative in their locomotor behavior...
  21. ncbi Childhood behavioral profiles leading to adolescent conduct disorder: risk trajectories for boys and girls
    Sylvana Côté
    Carnegie Mellon University, Pittsburgh, USA
    J Am Acad Child Adolesc Psychiatry 41:1086-94. 2002
    ..To examine the link between childhood behavioral dimensions and adolescent conduct disorder (CD) among a large sample of boys and girls monitored longitudinally...
  22. ncbi Voluntary access to a warm plate reduces hyperactivity in activity-based anorexia
    Jacquelien J G Hillebrand
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Physiol Behav 85:151-7. 2005
    ..These data suggest that ABA rats prefer to prevent hypothermia passively by choosing a warm plate rather than actively regulating body temperature by hyperactivity...
  23. ncbi On the role of noradrenaline in psychostimulant-induced psychomotor activity and sensitization
    Louk J M J Vanderschuren
    Drug Abuse Program, Department of Medical Pharmacology, Research Institute Neurosciences VU, VU Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Psychopharmacology (Berl) 169:176-85. 2003
    ....
  24. ncbi Is clinic prevalence of ICD-10 hyperkinesis underestimated? Impact of increasing awareness by a questionnaire screen in an UK clinic
    D M Foreman
    Department of Child and Adolescent Psychiatry, Keele University, Hartshill Stoke on Trent, United Kingdom
    Eur Child Adolesc Psychiatry 10:130-4. 2001
    ..is common, but its diagnosis is still controversial, with two contending approaches: ADHD from DSM IV and hyperkinesis from ICD-10. The concept of ADHD predicts higher rates, but its use may lead to overmedication...
  25. pmc Interplay of beta2* nicotinic receptors and dopamine pathways in the control of spontaneous locomotion
    Maria Elena Avale
    Unité Neurobiologie Intégrative des Systèmes Cholinergiques, Unité de Recherche Associée 2182, Centre National de la Recherche Scientifique, Institut Pasteur, F75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 105:15991-6. 2008
    ..These findings highlight the crucial interplay of nAChRs over the DA control of spontaneous locomotion...
  26. pmc The impact of hyperactivity and leptin on recovery from anorexia nervosa
    A A van Elburg
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    J Neural Transm 114:1233-7. 2007
    ..No major relationship of activity with the course of recovery was detected, suggesting that in contrast to the acute stage of the disease, leptin and activity levels during the recovery process are dissociated...
  27. ncbi Dynamic behavioural changes in the Spontaneously Hyperactive Rat: 1. Control by place, timing, and reinforcement rate
    Jonathan Williams
    Gatsby Computational Neuroscience Unit, Institute of Cognitive Neuroscience, University College, 17 Queen Square, London, WC1N 3AR, United Kingdom
    Behav Brain Res 198:273-82. 2009
    ..Alterations in learning rate are not a sufficient explanation for either SHR or ADHD difference from controls...
  28. ncbi Animal behavior models of the mechanisms underlying antipsychotic atypicality
    Mark A Geyer
    Department of Psychiatry, University of California at San Diego, 9500 Gilman Drive, 0804, La Jolla, CA 92093 0804, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:1071-9. 2003
    ..Moreover, there is an urgent need for animal models focusing more on the negative and the cognitive symptoms. Hence, improved animal models are crucial for developing better treatments for schizophrenia...
  29. ncbi Unraveling the nature of hyperactivity in children with attention-deficit/hyperactivity disorder
    Kyoko Ohashi
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02178, USA
    Arch Gen Psychiatry 67:388-96. 2010
    ..Seated hyperactivity is a defining feature of the combined and predominantly hyperactive-impulsive subtypes of attention-deficit/hyperactivity disorder (ADHD), but its underlying nature is unknown...
  30. ncbi Nitric oxide involves in carnosine-induced hyperactivity in chicks
    Shozo Tomonaga
    Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan
    Eur J Pharmacol 524:84-8. 2005
    ..These results suggest that carnosine-induced hyperactivity may be linked to the constitutive NOS (cNOS), rather than iNOS, in the brain. Central carnosine may regulate brain function and/or behaviors by NO generation via cNOS in chicks...
  31. ncbi 3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions
    M G Bankson
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555-1031, USA
    J Pharmacol Exp Ther 297:846-52. 2001
    ....
  32. ncbi Chromosomal mapping of excessive physical activity in mice in response to a restricted feeding schedule
    C Gelegen
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Centre Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:317-26. 2010
    ..Therefore, our data open new roads for interspecies genetic studies of AN and for unraveling novel mechanisms and potential effective treatment strategies for these neurobehavioral traits...
  33. ncbi Coloboma mouse mutant as an animal model of hyperkinesis and attention deficit hyperactivity disorder
    M C Wilson
    Department of Neurosciences, University of New Mexico, Health Sciences Center, Albuquerque 87131 5223, USA
    Neurosci Biobehav Rev 24:51-7. 2000
    b>Hyperkinesis and developmental behavioral deficiencies are cardinal signs of attention-deficit hyperactivity disorder...
  34. ncbi Further validation of LABORAS using various dopaminergic manipulations in mice including MPTP-induced nigro-striatal degeneration
    Leann P Quinn
    Neurology and GI CEDD, GlaxoSmithKline Pharmaceuticals, Harlow, Essex CM19 5AW, UK
    J Neurosci Methods 156:218-27. 2006
    ..The data captured and analysed using LABORAS, suggests that the automated system is able to detect both pharmacologically and lesion-induced changes in behaviour of mice, reliably and efficiently...
  35. ncbi Aripiprazole, an atypical antipsychotic, prevents the motor hyperactivity induced by psychotomimetics and psychostimulants in mice
    Juliana V Leite
    Department of Pharmacology, Ribeirao Preto School of Medicine, University of São Paulo Av Bandeirantes 3900, Ribeirao Preto SP, 14049 900, Brazil
    Eur J Pharmacol 578:222-7. 2008
    ..It also shows that aripiprazole may prevent the acute effects of psychostimulant drugs without significant motor impairment...
  36. pmc Bimodal effect of amphetamine on motor behaviors in C57BL/6 mice
    Jonathan W Yates
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Neurosci Lett 427:66-70. 2007
    ..These data provide a basis for using C57BL/6 mice as a strain to study the molecular and cellular mechanisms underlying psychostimulant effects, drug addiction and psychotic disorders...
  37. ncbi Differential role of serotonergic projections arising from the dorsal and median raphe nuclei in locomotor hyperactivity and prepulse inhibition
    Snezana Kusljic
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, Parkville, Australia
    Neuropsychopharmacology 28:2138-47. 2003
    ..This study may help to explain the role of different serotonin projections in the brain in the pathophysiology of schizophrenia...
  38. ncbi ST2472: a new potential antipsychotic with very low liability to induce side-effects
    Maria A Stasi
    Sigma Tau Industrie Farmaceutiche Riunite S p A, Pomezia, Rome, Italy
    Int J Neuropsychopharmacol 11:309-19. 2008
    ..In conclusion, ST2472 seems to be an antipsychotic with lower liability to produce side-effects than other antipsychotics, such as haloperidol, risperidone, olanzapine and clozapine, which were evaluated as reference drugs...
  39. ncbi The effect of combined treatment with imipramine and amantadine on the behavioral reactivity of central alpha1-adrenergic system in rats
    M Dziedzicka-Wasylewska
    Institute of Pharmacology, Polish Academy of Sciences, Krakow
    Behav Pharmacol 15:159-65. 2004
    ....
  40. ncbi Potential antidepressants: pharmacology of 2-(4-methyl piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile in rodent behavioural models
    R Mahesh
    Pharmacy Group, Birla Institute of Technology and Science, Pilani, Rajasthan, India
    Pharmazie 62:919-24. 2007
    ..This preliminary study points to a serotonergic mechanism behind the antidepressant-like effects of NA-2 and invigorates further investigation of analogous compounds in various other models of depression...
  41. ncbi Environmental enrichment enhances sensitization to GBR 12935-induced activity and decreases dopamine transporter function in the medial prefrontal cortex
    Jun Zhu
    College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Behav Brain Res 148:107-17. 2004
    ..These results suggest that EC-induced changes in activity may be due to decreased DAT function and decreased DA metabolism in the mPFC...
  42. ncbi Hyperactivity following postnatal NMDA antagonist treatment: reversal by D-amphetamine
    Anders Fredriksson
    University of Uppsala, Department of Neuroscience and Psychiatry, Ulleraker, SE 750 17 Uppsala, Sweden
    Neurotox Res 5:549-64. 2003
    ....
  43. ncbi Chronic microinjection of valproic acid into the nucleus accumbens attenuates amphetamine-induced locomotor activity
    Wha Young Kim
    Department of Physiology, Brain Korea 21 Project for Medical Science, Brain Research Institute, Yonsei University College of Medicine, 134 Shinchondong, Seodaemungu, Seoul 120 752, South Korea
    Neurosci Lett 432:54-7. 2008
    ..These results indicate that neuronal modifications in the NAcc induced by chronic valproic acid can modulate amphetamine-induced locomotor activity...
  44. ncbi Interaction between the noradrenergic and serotonergic systems in locomotor hyperactivity and striatal expression of Fos induced by amphetamine in rats
    A Munoz
    Laboratory of Neuroanatomy and Experimental Neurology, Dept of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Spain
    Exp Brain Res 153:92-9. 2003
    ..Concurrent stimulation of dopaminergic and serotonergic receptors appears necessary to regulate Amphetamine-induced responses in the striatal neurons...
  45. ncbi The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2/3 agonist, LY379268, in mouse models predictive of antipsychotic activity
    M L Woolley
    GlaxoSmithKline plc, Harlow, Essex, CM19 5AW, UK
    Psychopharmacology (Berl) 196:431-40. 2008
    ..Conversely, pre-clinical studies suggest that mGluR2 may be responsible for mediating the antipsychotic activity of mGluR2/3 agonists, although to date, the role of mGluR3 has not been specifically assessed...
  46. ncbi Stimulation of postsynaptic alpha1b- and alpha2-adrenergic receptors amplifies dopamine-mediated locomotor activity in both rats and mice
    Anne Sophie Villegier
    INSERM U 114, College de France, 75231 Paris, France
    Synapse 50:277-84. 2003
    ..Involvement of these adrenergic receptor mechanisms may be exploited in the therapy of Parkinson's disease...
  47. ncbi Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats
    Edmund Przegalinski
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Eur Neuropsychopharmacol 14:217-25. 2004
    ....
  48. ncbi Behavioural supersensitivity following neonatal 6-hydroxydopamine: attenuation by MK-801
    T Archer
    Department of Psychology, University of Goteborg, Sweden
    Neurotox Res 12:113-24. 2007
    ..The present findings confirm the influence of non-competitive glutamate antagonists in attenuating the behavioural supersensitivity to dopamine antagonists...
  49. pmc A reverse-translational approach to bipolar disorder: rodent and human studies in the Behavioral Pattern Monitor
    Jared W Young
    University of California San Diego, Department of Psychiatry, 9500 Gilman Dr, La Jolla, CA 92093 0603, USA
    Neurosci Biobehav Rev 31:882-96. 2007
    ..This unique approach to modeling BD provides an opportunity to identify the neurobiology underlying BD mania and test novel antimanic agents...
  50. ncbi A retinoic-acid critical period in the early postnatal mouse brain
    Tuanlian Luo
    E Kennedy Shriver Center at the University of Massachusetts Medical School, Waltham, MA 02452, USA
    Biol Psychiatry 56:971-80. 2004
    ..Very little is known about the role of retinoic acid in maturation of the mammalian forebrain...
  51. ncbi Synthesis and biological activity of picobenzide (3,5-dimethyl-N-(pyridin-4-ylmethyl)benzamide) analogues as potential antipsychotic agents
    Ana Gradillas
    Departamento de Químicas, Facultad de Farmacia, Universidad San Pablo CEU, Boadilla del Monte, Madrid Spain
    Arzneimittelforschung 55:725-9. 2005
    ..Two compounds showed a promising pharmacological profile in screening tests of antipsychotic activity, since they affected apomorphine-induced hyperactivity without significant effects on stereotypies...
  52. ncbi Bupropion hydrochloride produces conditioned hyperactivity in rats
    Jamie L Wilkinson
    University of Nebraska Lincoln, Department of Psychology, United States
    Physiol Behav 90:790-6. 2007
    ..However, a predictive relation between reactivity to forced novelty and the subsequent locomotor effect of bupropion may not be one of these similarities...
  53. ncbi Augmented cocaine-induced accumbal dopamine efflux, motor activity and place preference in rats fed with a tryptophan-deficient diet
    M Carta
    Department of Applied Sciences for Biosystems, Section of Physiology and Human Nutrition, University of Cagliari, Via Porcell 4, Cagliari 09124, Italy
    Neurosci Lett 401:125-9. 2006
    ..These data indicate that a tryptophan-deficient diet alters the behavioural and neurochemical effect of psychostimulants, such as cocaine, and suggest an important role of serotonin in modulation of these effects...
  54. ncbi Treatment with valproate after status epilepticus: effect on neuronal damage, epileptogenesis, and behavioral alterations in rats
    Claudia Brandt
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Neuropharmacology 51:789-804. 2006
    ....
  55. ncbi Actions at sites other than D(3) receptors mediate the effects of BP897 on l-DOPA-induced hyperactivity in monoamine-depleted rats
    Naomi P Visanji
    Toronto Western Research Institute, 399 Bathurst Street, MC11 419, Toronto, Ontario, Canada M5T 2S8
    Exp Neurol 202:85-92. 2006
    ..Thus, while BP897 may reduce LID, we raise the possibility that receptors other than D(3) receptors might be involved in this action...
  56. ncbi Myoclonus, motor deficits, alterations in emotional responses and monoamine metabolism in epsilon-sarcoglycan deficient mice
    Fumiaki Yokoi
    Department of Molecular and Integrative Physiology, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, 405 N Mathews Ave, Urbana, Illinois 61801, USA
    J Biochem 140:141-6. 2006
    ..Therefore, antipsychotic agents and serotonin reuptake inhibitors may offer potential benefits for M-D patients...
  57. ncbi Blockade of group II metabotropic glutamate receptors in the nucleus accumbens produces hyperlocomotion in rats previously exposed to amphetamine
    Henry Chi
    Department of Psychiatry, University of Chicago, 5841 South Maryland Avenue, MC3077, Chicago, IL 60637, USA
    Neuropharmacology 51:986-92. 2006
    ..These results indicate that group II mGluRs, particularly those found in the NAcc, are well positioned to modulate the expression of locomotor sensitization by amphetamine...
  58. ncbi Hyperlocomotion associated with transient prenatal vitamin D deficiency is ameliorated by acute restraint
    Thomas H J Burne
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Queensland 4076, Australia
    Behav Brain Res 174:119-24. 2006
    ..The time spent in the centre was not altered by prenatal diet or acute restraint. Thus, transient prenatal vitamin D deficiency induces a transient spontaneous hyperlocomotion in adulthood that is modulated by acute restraint stress...
  59. pmc Acute and chronic methylphenidate dose-response assessment on three adolescent male rat strains
    Pamela B Yang
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, 740 Westwood Blvd, Room A8 144, Los Angeles, CA 90024, USA
    Brain Res Bull 71:301-10. 2006
    ..These results suggest that the animal's age at time of drug treatment and strain/genetic variability play a crucial role in the acute and chronic effect of MPD and in the development of behavioral sensitization...
  60. ncbi Effects of clozapine plus lamotrigine on phencyclidine-induced hyperactivity
    Harriet J Williams
    Department of Pharmacology, Dalhousie University, Halifax, NS, Canada B3H 4H7
    Prog Neuropsychopharmacol Biol Psychiatry 30:239-43. 2006
    ..Therefore, LTG at doses that do not induce ataxia enhanced PCP-induced hyper-locomotion in rats, whereas the combination of LTG and CLZ significantly decreased PCP-induced hyper-locomotion consistent with clinical data...
  61. ncbi Seizure-prone EL/Suz mice exhibit physical and motor delays and heightened locomotor activity in response to novelty during development
    Melanie P McFadyen-Leussis
    Department of Psychology, Boston College, Chestnut Hill, MA 02467, USA
    Epilepsy Behav 6:312-9. 2005
    ..Overall, the present results demonstrate that the behavioral and physiological phenotype of seizure-prone EL/Suz mice is deviant more than 2 months before the onset of seizure susceptibility...
  62. ncbi Antipsychotic profile of rolipram: efficacy in rats and reduced sensitivity in mice deficient in the phosphodiesterase-4B (PDE4B) enzyme
    Judith A Siuciak
    CNS Discovery, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
    Psychopharmacology (Berl) 192:415-24. 2007
    ....
  63. ncbi Nucleus accumbens NMDA receptor subunit expression and function is enhanced in morphine-dependent rats
    Fraser Murray
    AstraZeneca, Alderley Park, Macclesfiled, Cheshire, SK10 4TG, UK
    Eur J Pharmacol 562:191-7. 2007
    ..Taken together, these data support several studies in the literature indicating that NMDA receptors in the nucleus accumbens are involved in the process of opiate dependence...
  64. ncbi Dietary cadmium exposure attenuates D-amphetamine-evoked [3H]dopamine release from striatal slices and methamphetamine-induced hyperactivity
    Dennis K Miller
    Department of Psychological Sciences, 208 McAlester Hall, University of Missouri, Columbia MO 65211, USA
    Pharmacol Biochem Behav 80:557-66. 2005
    ..This suggests that cadmium does not directly interfere with the mechanism of action for amphetamine pharmacology; rather, it suggests that long-term cadmium exposure induces a change in the number and/or function of striatal neurons...
  65. ncbi Adult mice with reduced Nurr1 expression: an animal model for schizophrenia
    P Rojas
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Mol Psychiatry 12:756-66. 2007
    ..This suggests that the Nurr1 mutant mouse may be a potential animal model for studies on some of the behavioral and molecular mechanisms underlying schizophrenia...
  66. ncbi DPP IV inhibitor blocks mescaline-induced scratching and amphetamine-induced hyperactivity in mice
    Susan L Lautar
    Guilford Pharmaceuticals, Inc, 6611 Tributary Street, Baltimore, MD 21224, USA
    Brain Res 1048:177-84. 2005
    ..Taken together, these data suggest that the antipsychotic effects of AMAC are the result of DPP IV inhibition...
  67. ncbi Mice with conditional inactivation of fibroblast growth factor receptor-2 signaling in oligodendrocytes have normal myelin but display dramatic hyperactivity when combined with Cnp1 inactivation
    Y Kaga
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030, USA
    J Neurosci 26:12339-50. 2006
    ....
  68. ncbi Brain serotonin depletion by lesions of the median raphe nucleus enhances the psychotomimetic action of phencyclidine, but not dizocilpine (MK-801), in rats
    Snezana Kusljic
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, Parkville, Australia
    Brain Res 1049:217-26. 2005
    ..Thus, MRN projections may play an inhibitory role in mechanisms involved in symptoms of schizophrenia...
  69. ncbi Arvanil, a hybrid endocannabinoid and vanilloid compound, behaves as an antihyperkinetic agent in a rat model of Huntington's disease
    Eva de Lago
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    Brain Res 1050:210-6. 2005
    ..Nevertheless, considering the lack of efficacious pharmacological treatments in this basal ganglia disorder, our findings might provide the basis for the development of more specific drugs against HD...
  70. pmc The neurochemical and behavioral effects of the novel cholinesterase-monoamine oxidase inhibitor, ladostigil, in response to L-dopa and L-tryptophan, in rats
    Yotam Sagi
    Eve Topf and U S A National Parkinson Foundation, Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Technion Rappaport Faculty of Medicine, Haifa, Israel
    Br J Pharmacol 146:553-60. 2005
    ....
  71. ncbi Hyperactivity in the rat is associated with spontaneous low level of n-3 polyunsaturated fatty acids in the frontal cortex
    S Vancassel
    Unité de Nutrition et Régulation Lipidique des Fonctions Cérébrales, NuReLice, INRA, Domaine de Vilvert, 78352 Jouy en Josas Cedex, France
    Behav Brain Res 180:119-26. 2007
    ..This differential model in rats should help to better understand the role of PUFA in several psychopathologies in which PUFA composition is modified...
  72. ncbi CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity
    Judith A Siuciak
    CNS Discovery, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
    Neuropharmacology 52:279-90. 2007
    ..These data suggest that 5-HT(2C) agonists may be a novel approach in the treatment of psychosis as well as for the improvement of cognitive dysfunction associated with schizophrenia...
  73. ncbi Hyperresponsiveness to phencyclidine in animals lesioned in the amygdala on day 7 of life. Implications for an animal model of schizophrenia
    E W P M Daenen
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Department of Pharmacology and Anatomy, P O Box 85060, 3508 AB Utrecht, The Netherlands
    Eur Neuropsychopharmacol 13:273-9. 2003
    ..The hyperresponsiveness to PCP in rats lesioned in the amygdala on day 7 of life further contributes to the validation of this putative animal model of schizophrenia...
  74. ncbi Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment
    Wha Young Kim
    Department of Physiology, Brain Korea 21 Project for Medical Science, Brain Research Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun gu, Seoul 120 752, South Korea
    Behav Brain Res 191:62-6. 2008
    ..These results suggest that activation of group II, but not of group I, mGluRs in the NAcc contributes to the expression of conditioned locomotion in an environment associated with amphetamine...
  75. ncbi Ischemia-induced hyperactivity: effects of dim versus bright illumination on open-field exploration and habituation following global ischemia in rats
    Marc Milot
    University of Ottawa, Ottawa, ON K1N 9A9, Canada
    Behav Brain Res 192:166-72. 2008
    ..These observations may help explain discrepant ischemia-induced behavioral effects reported in the open field...
  76. ncbi Subchronic continuous phencyclidine administration potentiates amphetamine-induced frontal cortex dopamine release
    Andrea Balla
    Nathan Kline Institute for Psychiatric Research, New York University School of Medicine, Orangeburg, NY 10962, USA
    Neuropsychopharmacology 28:34-44. 2003
    ..Finally, these studies provide a model system in which to evaluate effects of potential psychotherapeutic agents...
  77. ncbi Nonphysical contact between cagemates alleviates the social isolation syndrome in C57BL/6 male mice
    Susanna Pietropaolo
    Laboratory of Behavioural Neurobiology, ETH Zurich, Schwerzenbach, Switzerland
    Behav Neurosci 122:505-15. 2008
    ..Our results demonstrated for the first time the relevance of nonphysical contact including its ability to undermine the emergence of the isolation syndrome in mice...
  78. ncbi Ketamine induces hyperactivity in rats and hypersensitivity to nicotine in rat striatal slices
    Kelli R Rodvelt
    Department of Psychological Sciences, University of Missouri, Columbia, MO 65211, USA
    Pharmacol Biochem Behav 91:71-6. 2008
    ..These data indicate that the function of nicotinic acetylcholine receptors that mediate dopamine release are altered by ketamine, and support a role for nicotinic acetylcholine receptors in schizophrenia pathology...
  79. ncbi Antipsychotic property of a muscarinic receptor agonist in animal models for schizophrenia
    Shunsuke Maehara
    Department of Pharmacology, Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, 3 Okubo, Tsukuba, Ibaraki 300 2611, Japan
    Pharmacol Biochem Behav 91:140-9. 2008
    ....
  80. ncbi A novel black-hooded mutant rat (ci3) with spontaneous circling behavior but normal auditory and vestibular functions
    A Lessenich
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Neuroscience 107:615-28. 2001
    ..Apart from the use of ci3 rats for studying the functional lateralization of brain functions, the ci3 mutant may serve as a new model for movement disorders with abnormal lateralization...
  81. ncbi The muscarinic receptor agonist xanomeline has an antipsychotic-like profile in the rat
    K J Stanhope
    Vernalis Research Limited, Winnersh, Wokingham, United Kingdom
    J Pharmacol Exp Ther 299:782-92. 2001
    ..The antipsychotic-like effects of xanomeline in the animal models used here suggest that it may be a useful treatment for psychosis...
  82. ncbi Stimulation of metabotropic but not ionotropic glutamatergic receptors in the nucleus accumbens is required for the D-amphetamine-induced release of functional dopamine
    L Darracq
    INSERM U114, , 11 place Marcelin-Berthelot, 75231 Cedex 05, Paris, France
    Neuroscience 103:395-403. 2001
    ..We suggest that the activation of metabotropic glutamate receptors in the nucleus accumbens is required for functional dopamine release following systemic D-amphetamine injection...
  83. ncbi Subchronic and chronic PCP treatment produces temporally distinct deficits in attentional set shifting and prepulse inhibition in rats
    Alice Egerton
    Psychiatric Research Institute of Neuroscience in Glasgow PsyRING, University of Glasgow, Glasgow, G12 8QQ, UK
    Psychopharmacology (Berl) 198:37-49. 2008
    ..6 mg/kg PCP) and chronic intermittent administration of 2.6 mg/kg PCP to rats produces hypofrontality and other neurochemical changes akin to schizophrenia pathology (Cochran et al., Neuropsychopharmacology, 28:265-275, 2003)...
  84. ncbi Inhibitory effects of D2 agonists by striatal injection on excessive release of dopamine and hyperactivity induced by Bay K 8644 in rats
    H Maruya
    Department of Internal Medicine III, Tokyo Medical University, 6 7 1 Nishi Shinjujku, Shinjuku ku, Tokyo 160 0023, Japan
    Neuroscience 118:1091-8. 2003
    ..Consequently, the effect of D(2) agonists in the clinical treatment of Parkinson's disease may be due to stimulation of postsynaptic D(2) receptors rather than presynaptic autoreceptors...
  85. ncbi Effects of sodium arsenite exposure on development and behavior in the rat
    V M Rodriguez
    Center for Neurobiology, Campus UNAM Juriquilla, P O Box 1 1141, Qere taro, Qro 76001, Mexico
    Neurotoxicol Teratol 24:743-50. 2002
    ..These results indicate that rats exposed to arsenic during development present deficits in spontaneous locomotor activity and alterations in a spatial learning task...
  86. ncbi Group II mGlu receptor activation suppresses norepinephrine release in the ventral hippocampus and locomotor responses to acute ketamine challenge
    Daniel S Lorrain
    Department of Neuropharmacology, Merck Research Laboratories, San Diego, CA 92121, USA
    Neuropsychopharmacology 28:1622-32. 2003
    ....
  87. pmc Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein
    Steven L Senior
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Eur J Neurosci 27:947-57. 2008
    ..Rather, we propose that loss of both alpha- and gamma-synuclein causes an increase in release probability from dopaminergic synapses...
  88. ncbi Further dissection of a genomic locus associated with behavioral activity in the Wistar-Kyoto hyperactive rat, an animal model of hyperkinesis
    M P Moisan
    Laboratory of Neurogenetics and Stress, INSERM U471 INRA UR 502, Institut Francois Magendie, Bordeaux, France
    Mol Psychiatry 8:348-52. 2003
    ..1) Our approach has been to search for quantitative trait loci (QTL) in a genetic animal model of hyperkinesis, the Wistar-Kyoto hyperactive (WKHA) rat, by a whole-genome scan analysis...
  89. ncbi Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease
    Isabel Lastres-Becker
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    J Neurochem 84:1097-109. 2003
    ....
  90. ncbi [Asynchrony of ventricular contraction and relaxation--pathophysiologically recognized phenomenon, now can be clinically assessed]
    C Bruch
    Abteilung fur Kardiologie, Universitat Essen
    Herz 23:506-15. 1998
    ..The maximum amplitude is reached in early diastole ("post-ejection thickening"). Since hyperkinesis develops in the normal region, the ischemic and the normal region contract asynchronously...
  91. ncbi Features of central neurotransmission in animals in conditions of dietary magnesium deficiency and after its correction
    A A Spasov
    Research Institute of Pharmacology and Department of Pharmacology, Volgograd State Medical University, 1 Pavshikh Bortsov Square, 400131, Volgograd, Russia
    Neurosci Behav Physiol 39:645-53. 2009
    ..Thus, dietary magnesium deficiency led to impairment of neurotransmission in central serotoninergic, M-cholinergic, and noradrenergic structures and administration of magnesium salts reversed these changes...
  92. ncbi Neuropsychiatric assessment of Gilles de la Tourette patients: comparative study with other hyperkinetic and hypokinetic movement disorders
    J Kulisevsky
    Movement Disorders Unit, Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, Spain
    Mov Disord 16:1098-104. 2001
    ..Abnormalities of other brain structures (e.g., amygdala, brainstem nuclei) may account for the significantly higher anxiety scores differentiating GTS from HD patients...
  93. ncbi An open-label dose-titration study of the efficacy and tolerability of tizanidine hydrochloride tablets in the prophylaxis of chronic daily headache
    J R Saper
    Michigan Head-Pain and Neurological Institute, Ann Arbor 48104, USA
    Headache 41:357-68. 2001
    ..treatment due to adverse events: somnolence and dry mouth alone (n = 1), or in combination with either hyperkinesis (n = 1) or constipation (n = 1)...
  94. pmc Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease
    P H Reddy
    Genetics and Molecular Biology Branch, National Institutes of Health, Bethesda, MD 20892, USA
    Philos Trans R Soc Lond B Biol Sci 354:1035-45. 1999
    ..Thus, animals expressing the CAG repeat expansions appear to represent clinically analogous models for HD pathogenesis, and may also provide insights into the underlying pathophysiological mechanisms of other triplet repeat disorders...
  95. ncbi Experimental infection of cattle with Trypanosoma brucei rhodesiense
    B T Wellde
    Walter Reed Project, Veterinary Research Laboratory, Ministry of Agriculture and Livestock Development, Kabete, Kenya
    Ann Trop Med Parasitol 83:133-50. 1989
    ..Demyelination was limited to perivascular areas. Occasionally a moderate to severe pancarditis was found...
  96. ncbi Tako-tsubo-like left ventricular dysfunction: clinical presentation, instrumental findings, additional cardiac and non-cardiac diseases and potential pathomechanisms
    C Stollberger
    Krankenanstalt Rudolfstiftung, Medizinische Abteilung, Wien, Osterreich
    Minerva Cardioangiol 53:139-45. 2005
    ..catecholamine levels, coronary vasospasm, atherosclerotic plaques rupture, myocarditis, catecholamine-induced hyperkinesis of the basal left ventricular segments and genetic...
  97. ncbi Role of central histaminergic system in lorazepam withdrawal syndrome in rats
    C Nath
    Division of Pharmacology, Central Drug Research Institute, Lucknow, India
    Pharmacol Biochem Behav 68:777-82. 2001
    ..Astemizole, a peripheral antagonist of H1 receptor, could not affect any withdrawal sign. It may be concluded that histamine H1 receptors are facilitatory and H3 receptors are inhibitory for benzodiazepine (BZD) withdrawal syndrome...
  98. ncbi Tako-tsubo-like left ventricular dysfunction with ST-segment elevation: a novel cardiac syndrome mimicking acute myocardial infarction
    Satoshi Kurisu
    Division of Cardiology, Hiroshima City Hospital, Hiroshima, Japan
    Am Heart J 143:448-55. 2002
    Peculiar asynergy, which consists of hypokinesis or akinesis from the mid portion to the apical area and hyperkinesis of the basal area on contrast left ventriculogram, is rare...
  99. ncbi Spinocerebellar degenerations
    Susan L Perlman
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Handb Clin Neurol 100:113-40. 2011
    ..Some testing should be done even in individuals with a confirmed genetic cause, as the presence of a secondary factor (nutritional deficiency, thyroid dysfunction) can contribute to the phenotype...
  100. ncbi Neuropsychiatric assessment of patients with hyperkinetic and hypokinetic movement disorders
    I Litvan
    Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 9130, USA
    Arch Neurol 55:1313-9. 1998
    ....
  101. ncbi Prospective open-label clinical trial of trihexyphenidyl in children with secondary dystonia due to cerebral palsy
    Terence D Sanger
    Stanford University, Stanford, California, USA
    J Child Neurol 22:530-7. 2007
    ..A larger, randomized prospective trial stratified by the presence or absence of hyperkinetic movements is needed to confirm these results...

Research Grants60

  1. RNA interference therapy for Huntington's disease: studies in non-human primates
    Beverly L Davidson; Fiscal Year: 2010
    ..This work is a collaborative effort between laboratories at the University of Iowa and the Oregon National Primate Research Center at the Oregon Health Sciences University. ..
  2. Ph 2 Study of Dextromethorphan in the Treatment of Rett Syndrome
    SAKKUBAI R NAIDU; Fiscal Year: 2013
    ..Analyses will be done on an intention-to-treat basis. Our previous study showing improved alertness and social interaction on neuropsychological and behavioral assessments is encouraging. ..
  3. Optimizing communication devices for children with dyskinetic cerebral palsy
    Terence D Sanger; Fiscal Year: 2012
    ....
  4. PET IN HYPERKINETIC DISORDERS--A MULTICENTER STUDY
    David Eidelberg; Fiscal Year: 2001
    ..This approach may have great utility in evaluating new interventions for the treatment of the hyperkinetic movement disorders. ..
  5. EYE MOVEMENT OF HYPERKINETIC CHILDREN
    Bernard Cohen; Fiscal Year: 1980
    ..The goal of the research is to gain insight into the pathophysiology of the hyperkinetic syndrome and to develop measures which will aid in the diagnosis of hyperkinesis and the evaluation of treatment.
  6. Improving memory after hippocampal cell loss
    MARK BARDGETT; Fiscal Year: 2007
    ..The results may shed light on new directions in the treatment of memory disorders, and the proposed work will also enhance education in biomedical research among college undergraduates in Kentucky. [unreadable] [unreadable] [unreadable]..
  7. Dopamine D4 Receptor in Sustained Attention
    Kehong Zhang; Fiscal Year: 2003
    ..The findings may also provide a pharmacological basis for innovative treatment for ADHD to replace stimulant therapy. ..
  8. Viral neuropathology neuropeptides and epilepsy
    Marylou Solbrig; Fiscal Year: 2005
    ....
  9. REGULATION OF NEUROTRANSMISSION AND BEHAVIOR
    Michael Wilson; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  10. DOPAMINE NEUROTRANSMISSION IN EXPERIMENTAL PARKINSONISM
    PAUL GARRIS; Fiscal Year: 2005
    ..Moreover, L-DOPA is associated with adverse side effects after extended use, apparently due to non-physiological dopamine replacement. However, how L-DOPA acts on dopaminergic signaling is not completely established. ..
  11. Neural control of abnormal movement
    Terence Sanger; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  12. Risk and Protective Factors in School Maladjustment
    GARY LADD; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  13. Serotonin Club IUPHAR Satellite Meeting
    Mark Geyer; Fiscal Year: 2006
    ..Hence, helping neuroscientists-in-training attend the meeting will have a positive influence on trainees and a lasting impact on the field. [unreadable] [unreadable] [unreadable]..
  14. NEUROBEHAVIORAL PHARMACOLOGY OF STIMULANTS
    Kathryn A Cunningham; Fiscal Year: 2010
    ....
  15. Childhood Motor Impairment and Assisted Communication
    Terence Sanger; Fiscal Year: 2004
    ....
  16. Failure of Motor Learning in Childhood Dystonia
    Terence D Sanger; Fiscal Year: 2010
    ..These experiments will demonstrate a potentially important contributor to motor symptoms in dystonia, and they will indicate specific new treatment opportunities. ..
  17. Mechanisms of Amphetamine Action on Dopaminergic Signaling
    PAUL GARRIS; Fiscal Year: 2007
    ..New microsensor technology will be employed in laboratory animals to characterize amphetamine's effect on brain chemistry related to learning and motivaton. [unreadable] [unreadable] [unreadable]..
  18. A Simple Measure for Studying Sensory Gating Deficits
    Neal Swerdlow; Fiscal Year: 2007
    ..abstract_text> ..
  19. Neural basis of heritable DA-mediated gating deficits
    Neal R Swerdlow; Fiscal Year: 2010
    ....
  20. Targeted Proteomics of Stress and Addiction
    KATHRYN CUNNINGHAM; Fiscal Year: 2005
    ..abstract_text> ..
  21. Computational Modeling of Developmental Processes
    LARRY TABER; Fiscal Year: 2009
    ..This software will open up new avenues for studying the mechanics of development in the cardiovascular, nervous, and other systems composed of soft tissue. ..
  22. Early Identification of Adverse Reactions to Herbs
    Stephen Bent; Fiscal Year: 2007
    ..Ultimately, this research strives to identify improved methods for the early detection of adverse events, providing patients with a safer environment to achieve the potential benefits of herbal products. ..
  23. Chronic Alcohol & AIDS Impact on Muscle Wasting
    Patricia Molina; Fiscal Year: 2006
    ..abstract_text> ..
  24. VALIDITY OF DSM-IV SUBTYPES OF ADHD FOR YOUNG CHILDREN
    Benjamin Lahey; Fiscal Year: 2009
    ..Answering these questions will inform taxonomy, etiologic theory, and assist future efforts at targeted prevention. ..
  25. DEVELOPMENTAL MODELS OF GATING DEFICITS IN SCHIZOPHRENIA
    Mark A Geyer; Fiscal Year: 2010
    ..Hence, Aim 3 studies will test the hypothesized differential roles of specific CRF receptors in mediating isolation rearing-induced deficits in PPI in mice, using CRF-R1 and CRF-R2 null mutant mice. ..
  26. FUNCTIONAL CONSEQUENCES OF VACCINATION IN AD TG MICE
    David Morgan; Fiscal Year: 2010
    ..Success in these aims will identify conditions of passiveimmunization which maximizethe cognitive benefitswhile retaining high levels of patient safety for clinical trials in patients with Alzheimer's disease. ..
  27. ROLE OF THE HIGH AFFINITY NICOTINE RECEPTOR IN ADDICTION
    MARINA PICCIOTTO; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  28. TRICCS: Targeting Inattention in Childhood Cancer Survivors
    Kristina Hardy; Fiscal Year: 2008
    ..Further, we predict that increases in working memory and attention from baseline to post-intervention will be of moderate effect size, and will be maintained at 3-month follow-up. [unreadable] [unreadable] [unreadable] [unreadable]..
  29. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal R Swerdlow; Fiscal Year: 2010
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  30. Computational and Experimental Study of Early Cardiac Morphogenesis
    LARRY TABER; Fiscal Year: 2009
    ..In addition, the computational model created during the course of our research may someday lead to advanced models of the developing human heart, which is not amenable to direct experimental study. ..
  31. NICOTINE ADDICTION IN MICE LACKING THE NEURONAL NACHR
    MARINA PICCIOTTO; Fiscal Year: 2009
    ..We propose that this mouse model may have implications for the development of psychiatric disorders in subjects exposed to nicotine in utero. ..
  32. Genetic Epidemiology of Youth Conduct Problems
    Benjamin Lahey; Fiscal Year: 2007
    ..These include maternal age at first birth, maternal smoking during pregnancy, family socioeconomic status, neighborhood socioeconomic status, neighborhood social disorganization, and urbanicity. ..
  33. CNS VIRAL INJURY AND VULNERABILITY TO OPIATE DRUG ABUSE
    Marylou Solbrig; Fiscal Year: 2002
    ..At the conclusion of the grant period, the requisite skills in behavioral pharmacology, neuropharmacology and molecular biology for continued work in the study and treatment of drug addiction will have been acquired by the candidate. ..
  34. RISK & PROTECTIVE FACTORS IN EARLY SCHOOL MALADJUSTMENT
    GARY LADD; Fiscal Year: 2001
    ..g., anxiety, depression, loneliness, low self-esteem), and (c) school failure (e.g., underachievement, scholastic disengagement, school avoidance, truancy, suspensions, and drop out). ..
  35. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  36. Role of the a4b2 Nicotine Receptor in Neuropathology
    JANICE CARLSON; Fiscal Year: 2003
    ..It is my hope that these experiments will shed light on how nicotine is both neurotoxic and neuroprotective, and how the alpha4beta2 receptor may be involved in these seemingly opposite effects. ..
  37. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  38. Neuropsychopharmacol Interactions - Cocaine & Serotonin
    KATHRYN CUNNINGHAM; Fiscal Year: 2004
    ..Thus, the release time and salary support provided by this K02 would continue to enhance the development of my career in the science of drug dependence. ..
  39. Cerebellar-Striatal-Prefrontal Dysfunction in ADHD
    Francisco Castellanos; Fiscal Year: 2004
    ..Eventually, such advances in nosology will lead to improved matches between treatment options and the underlying disorder(s). ..
  40. Alcoholism and Disease: Immune /Pathological Mechanisms
    Patricia Molina; Fiscal Year: 2002
    ..The proceedings of these symposia will be published and a summary report to the NIAAA will be prepared. ..
  41. Emotional and attentional biases to drug and trauma cues in addiction with PTSD
    Estate Sokhadze; Fiscal Year: 2006
    ..Decreased frontal topdown control further contributes to inability to override these automatic responses and addictive behaviors. [unreadable] [unreadable] [unreadable]..
  42. Arm Kinematics in Hyperkinetic Cerebral Palsy
    Terence Sanger; Fiscal Year: 2005
    ..Hlatky will guide the design and implementation of clinical trials and outcome measure validation. The proposal includes coursework in cellular and molecular neurobiology and in the design of clinical research studies. ..
  43. Neuroscience at the Boundaries of Neurology and Psychiatry
    Neal Swerdlow; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  44. NEURAL CIRCUITRY OF SENSORIMOTOR GATING ACROSS SPECIES
    Neal Swerdlow; Fiscal Year: 2006
    ....
  45. NEUROPSYCHOPHARMACOLOGY MDMA--MONOAMINERGIC MECHANISMS
    KATHRYN CUNNINGHAM; Fiscal Year: 2005
    ..abstract_text> ..
  46. NIH Task Force on Childhood Motor Disorders
    Terence Sanger; Fiscal Year: 2006
    ..The ultimate objective is to improve the functional abilities and societal participation of children with motor disorders. ..
  47. Cannabinoid effects on HIV/AIDS
    Patricia E Molina; Fiscal Year: 2010
    ....
  48. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  49. Genetic Studies of Substance Abuse in Iowa Adoptees
    Robert Philibert; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  50. A thyroid receptor co-activator hypothesis for psychosis
    Robert Philibert; Fiscal Year: 2005
    ..The net effect will be to produce an independent investigator capable of functional and translational research. ..
  51. AAV Gene Therapy for Alzheimer's Disease
    David Morgan; Fiscal Year: 2009
    ..The outcome of these studies will, hopefully, be a novel gene therapeutic approach to dismantle the catastrophe of Alzheimer's dementia. ..
  52. STARTLE GATING AND LOCOMOTION IN D2-FAMILY KNOCKOUT MICE
    Mark Geyer; Fiscal Year: 2004
    ..This information will have important implications for the further development of therapeutic approaches to the treatment of both schizophrenia and drug abuse. ..
  53. BIOMECHANICS OF LOOPING IN THE EMBRYONIC HEART
    LARRY TABER; Fiscal Year: 2003
    ..Defining the biomechanical forces involved in looping would provide insight into this morphogenetic process and thereby help researchers searching for the link between gene expression and looping morphology. ..
  54. BASIC DIMENSIONS OF CHILD AND ADOLESCENT PSYCHOPATHOLOGY
    Benjamin Lahey; Fiscal Year: 2004
    ..Potential development and gender differences in the dimensions of psychopathology will be evaluated using structural equation modeling. ..
  55. In Vivo BM Stem Cell Gene Transfer for MPS type I
    Dao Pan; Fiscal Year: 2006
    ..Taken together, these data would not only open a door to a novel approach for treatment of human diseases, but also provide a new tool to study adult stem cell plasticity and the nature of hematopoiesis. ..
  56. A vaccine approach to Parkinson's disease
    David Morgan; Fiscal Year: 2003
    ..Success will encourage further development of a vaccine as a therapeutic agent in PD. ..