Genomes and Genes
Summary: A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. The limbs tend to remain in whatever position they are placed (waxy flexibility). Catalepsy may be associated with PSYCHOTIC DISORDERS (e.g., SCHIZOPHRENIA, CATATONIC), nervous system drug toxicity, and other conditions.
Publications222 found, 100 shown here
- Glutamatergic neurotransmission mediated by NMDA receptors in the inferior colliculus can modulate haloperidol-induced catalepsyL L Melo
Laboratorio de Neuropsicofarmacologia, Universidade São Francisco, Av São Francisco de Assis, 218, Braganca Paulista, SP, 12916 900, Brasil
Brain Res 1349:41-7. 2010..The present study examined the influence of excitatory amino acid-mediated mechanisms in the IC on the catalepsy induced by the dopamine receptor blocker haloperidol administered systemically (1 or 0.5 mg/kg) in rats...
- BL-1020: a novel antipsychotic drug with GABAergic activity and low catalepsy, is efficacious in a rat model of schizophreniaYona Geffen
BioLineRx Ltd, 19 Hartum Street, Jerusalem, Israel
Eur Neuropsychopharmacol 19:1-13. 2009..Oral BL-1020 or perphenazine were assessed in acute and subchronic schizophrenia rat models. Catalepsy, serum prolactin, receptor binding profile and cortical (PFC), hippocampal (Hip) and dopamine (DA) levels were ..
- Gene networks and haloperidol-induced catalepsyO D Iancu
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA
Genes Brain Behav 11:29-37. 2012..These results suggest that a network-based strategy will help identify the genetic factors associated with haloperidol response...
- Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsyKenneth J Valenzano
Department of Pharmacology, Purdue Pharma Discovery Research, Cranbury, NJ 08512, USA
Neuropharmacology 48:658-72. 2005..However, activation of CB1 receptors is also associated with central side effects, including ataxia and catalepsy. More recently, a role for selective CB2 agonists in pain modification has been demonstrated...
- Caffeine and muscarinic antagonists act in synergy to inhibit haloperidol-induced catalepsyRosa E Moo-Puc
Laboratorio de Neurofisiologia, Centro de Investigaciones Regionales, Dr Hideyo Noguchi, Universidad Autonoma de Yucatan, Avenida Itzaes No 490, Merida, Yucatan 97000, Mexico
Neuropharmacology 45:493-503. 2003The possible synergism between caffeine and muscarinic antagonists to inhibit haloperidol-induced catalepsy was investigated with the bar test in rats...
- A new synthetic varacin analogue, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153), decreased hereditary catalepsy and increased the BDNF gene expression in the hippocampus in miceAlexander V Kulikov
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia
Psychopharmacology (Berl) 221:469-78. 2012..The creation of effective psychotropic drugs is the key problem of psychopharmacology. Natural compounds and their synthetic analogues attract particular attention...
- Differential network analysis reveals genetic effects on catalepsy modulesOvidiu D Iancu
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
PLoS ONE 8:e58951. 2013We performed short-term bi-directional selective breeding for haloperidol-induced catalepsy, starting from three mouse populations of increasingly complex genetic structure: an F2 intercross, a heterogeneous stock (HS) formed by crossing ..
- 5-HT1A receptor activation and anti-cataleptic effects: high-efficacy agonists maximally inhibit haloperidol-induced catalepsyEric P M Prinssen
Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F 81106 Cedex, Castres, France
Eur J Pharmacol 453:217-21. 2002Studies have shown that 5-HT1A receptor ligands modulate antipsychotic-induced catalepsy. Here, we further examined the role of intrinsic activity at 5-HT1A receptors in these effects...
- Cannabidiol attenuates catalepsy induced by distinct pharmacological mechanisms via 5-HT1A receptor activation in miceFelipe V Gomes
Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, Ribeirao Preto, SP, 14049 900, Brazil Center for Interdisciplinary Research on Applied Neurosciences NAPNA, University of Sao Paulo, Brazil Electronic address
Prog Neuropsychopharmacol Biol Psychiatry 46:43-7. 2013..To investigate this possibility we evaluated if CBD would prevent catalepsy induced by drugs with distinct pharmacological mechanisms...
- Dopaminergic mechanisms underlying catalepsy, fear and anxiety: do they interact?Ana Caroline Colombo
Laboratorio de Psicobiologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil Instituto de Neurociências e Comportamento INeC, Ribeirao Preto, SP, Brazil
Behav Brain Res 257:201-7. 2013Haloperidol is a dopamine D2 receptor antagonist that induces catalepsy when systemically administered to rodents. The haloperidol-induced catalepsy is a state of akinesia and rigidity very similar to that seen in Parkinson's disease...
- Modulation of haloperidol-induced catalepsy in rats by GABAergic neural substrate in the inferior colliculusJ G Tostes
Laboratorio de Neuropsicofarmacologia, Universidade São Francisco, Avenida São Francisco de Assis, 218, Braganca Paulista, SP 12916 900, Brazil Faculdade de Medicina de Itajubá, Avenida Renó Júnior, 368, São Vicente, Itajuba, MG 37502 138, Brazil
Neuroscience 255:212-8. 2013..the IC to motor behavior shows that glutamate-mediated mechanisms within the IC modulate haloperidol-induced catalepsy. The high density of GABAergic receptors in the IC led to this study of a possible link between these receptors, ..
- Haloperidol catalepsy consolidation in the rat as a model of neuromodulatory integrationA S Bazyan
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia
Neuroscience 99:279-88. 2000..Haloperidol administration (2.5 mg/kg i.p.) evoked catalepsy and increased the content of noradrenaline and dopamine in the same structures of the brain...
- Modulation by female sex hormones of the cannabinoid-induced catalepsy and analgesia in ovariectomized miceDina Kalbasi Anaraki
Department of Pharmacology, School of Medicine, Medical Sciences University of Tehran, P O Box 13145 784, Tehran, Iran
Eur J Pharmacol 586:189-96. 2008Cannabinoids are psychoactive compounds with many pharmacological properties such as analgesia, sedation and catalepsy most of which are mediated by cannabinoid CB1 receptors...
- The neurotensin-1 receptor agonist PD149163 inhibits conditioned avoidance responding without producing catalepsy in ratsElizabeth N Holly
Psychology Department, Northern Michigan University, 1401 Presque Isle Ave, Marquette, Michigan, USA
Eur Neuropsychopharmacol 21:526-31. 2011..0 or 8.0 mg/kg dose. PD149163 failed to significantly increase catalepsy scores. The typical antipsychotic drug haloperidol (0.01-1.0 mg/kg) significantly suppressed CAR at a 0.1, 0...
- Identification of quantitative trait loci for haloperidol-induced catalepsy on mouse chromosome 14E Rasmussen
Department of Psychiatry and Psychology, State University of New York at Stony Brook, Stony Brook, New York, USA
J Pharmacol Exp Ther 290:1337-46. 1999Previous studies have established that neuroleptic-induced catalepsy in mice is a highly heritable trait...
- Haloperidol-induced catalepsy is absent in dopamine D(2), but maintained in dopamine D(3) receptor knock-out miceD Boulay
Department of Psychopharmacology, Sanofi Synthelabo, 31 Ave P Vaillant Couturier, 92220, Bagneux, France
Eur J Pharmacol 391:63-73. 2000..mice homozygous for the deletion of the dopamine D(2) receptor gene (D(2)(-/-) mice) do not present spontaneous catalepsy when tested in a "bar test"...
- Neuroleptic-induced catalepsy: electrophysiological mechanisms of functional recovery induced by high-frequency stimulation of the subthalamic nucleusBertrand Degos
Institut National de la Santé et de la Recherche Médicale Unité 667, College de France, 75231 Paris Cedex 05, France
J Neurosci 25:7687-96. 2005..receptors, respectively, were performed, and the parameters of STN HFS that reversed the neuroleptic-induced catalepsy were determined in freely moving animals...
- Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implicationsGiorgio Marchese
Neuroscienze S c a r l, Cagliari 09123, Italy
Br J Pharmacol 140:520-6. 2003The effect on rat catalepsy induced by Delta9-tetrahydrocannabinol (Delta9-THC) in association with haloperidol (HP) or clozapine (CLOZ) administration was investigated. Delta9-THC dose-dependently increased HP (0.05-1 mg kg-1, s.c...
- The orexin-1 antagonist SB-334867 blocks antipsychotic treatment emergent catalepsy: implications for the treatment of extrapyramidal symptomsKurt Rasmussen
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
Schizophr Bull 33:1291-7. 2007..Pretreatment with SB-334867 (0.01-10 mg/kg, intraperitoneal [IP]) significantly decreased the catalepsy produced by the administration of haloperidol (1 mg/kg, subcutaneous [SC]), risperidone (2 mg/kg, SC), and ..
- Intracerebroventricular administration of nitric oxide-sensitive guanylyl cyclase inhibitors induces catalepsy in miceM B Echeverry
Department MEF Physiology, FORP, University of Sao Paulo, Av Café S No, 14040 904, Ribeirao Preto, SP, Brazil
Psychopharmacology (Berl) 194:271-8. 2007b>Catalepsy is a preclinical test that predicts extrapyramidal symptoms in humans. It models symptoms of acute extrapyramidal side effects induced at the beginning of antipsychotic treatment...
- Catalepsy induced by intra-striatal administration of nitric oxide synthase inhibitors in ratsElaine A Del Bel
Department MEF Physiology, School of Odontology, FORP, Campus USP, Av Café S N, Ribeirao Preto, SP 14040 904, Brazil
Eur J Pharmacol 485:175-81. 2004Systemic administration of nitric oxide synthase (NOS) inhibitors induces catalepsy in a dose-dependent manner in male Albino-Swiss mice...
- Coadministration of L-NOARG and tiapride: effects on catalepsy in male miceMaria Cavas
Department of Psychobiology, School of Psychology, , Spain
Prog Neuropsychopharmacol Biol Psychiatry 26:69-73. 2002This study was designed to determine the possible potentiation of catalepsy behavior after coadministration of N(G)-nitro-L-arginine (L-NOARG), an inhibitor of nitric oxide synthase (NOS), and tiapride, a specific antagonist for D2 ..
- Acute effects of selective serotonin reuptake inhibitors on neuroleptic-induced catalepsy in miceJ G P Pires
Departamento de Ciencias Fisiologicas, Centro Biomedico, Universidade Federal do Espirito Santo, Av Marechal Campus 1468, 29040 090 Vitória, ES, Brazil
Braz J Med Biol Res 38:1867-72. 2005..Drugs that modify experimental neuroleptic catalepsy (NC) might affect extrapyramidal symptoms in PD...
- Evaluation of age and sex differences in locomotion and catalepsy during repeated administration of haloperidol and clozapine in adolescent and adult ratsJenny L Wiley
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
Pharmacol Res 58:240-6. 2008..Rats were injected daily with saline, 0.3 mg/kg haloperidol, or 10 mg/kg clozapine for 10 days and activity and catalepsy were measured...
- Mirtazapine enhances the effect of haloperidol on apomorphine-induced climbing behaviour in mice and attenuates haloperidol-induced catalepsy in ratsH H Berendsen
Department of Neuropharmacology, N V Organon, Oss, The Netherlands
Psychopharmacology (Berl) 135:284-9. 1998Activation of 5-HT1A receptors has been shown to attenuate catalepsy induced by typical antipsychotic compounds...
- Sub-chronic inhibition of nitric-oxide synthesis modifies haloperidol-induced catalepsy and the number of NADPH-diaphorase neurons in miceE A Del Bel
Department of Physiology, School of Odontology, FORP, Ribeirao Preto, SP, Brazil
Psychopharmacology (Berl) 147:356-61. 2000NG-nitro-L-arginine (L-NOARG), an inhibitor of nitric-oxide synthase (NOS), induces catalepsy in mice. This effect undergoes rapid tolerance, showing a significant decrease after 2 days of sub-chronic L-NOARG treatment...
- Catalepsy induced by a blockade of dopamine D1 or D2 receptors was reversed by a concomitant blockade of adenosine A(2A) receptors in the caudate-putamen of ratsW Hauber
Department of Animal Physiology, Institute of Biology, University of Stuttgart, D 70550 Stuttgart, Germany
Eur J Neurosci 14:1287-93. 2001..to determine, in more detail, the effects of an unselective and a selective adenosine A(2A) receptor blockade on catalepsy induced by a blockade of dopamine D1 or D2 receptors in rats...
- Loss of haloperidol induced gene expression and catalepsy in protein kinase A-deficient miceM R Adams
Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 94:12157-61. 1997..These results establish a direct role for protein kinase A as a mediator of haloperidol induced gene induction and cataleptic behavior...
- Detection and mapping of quantitative trait loci for haloperidol-induced catalepsy in a C57BL/6J x DBA/2J F2 intercrossN V Patel
Department of Psychiatry, SUNY 11794 8101, USA
Behav Genet 29:303-10. 1999A genomewide scan was conducted to detect quantitative trait loci (QTLs) for haloperidol-induced catalepsy in a C57BL/6J (B6) x DBA/2J (D2) F2 intercross (N = 678). Significant QTLs (LOD, > 4.3) were detected on chromosomes 1 and 9...
- Delta 9-tetrahydrocannabinol-induced catalepsy-like immobilization is mediated by decreased 5-HT neurotransmission in the nucleus accumbens due to the action of glutamate-containing neuronsK Sano
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8 19 1, Fukuoka City, Fukuoka 814 0180, Japan
Neuroscience 151:320-8. 2008Delta(9)-tetrahydrocannabinol (THC) has been reported to induce catalepsy-like immobilization, but the mechanism underlying this effect remains unclear...
- Characterization of the quantitative trait locus for haloperidol-induced catalepsy on distal mouse chromosome 1J R Hofstetter
Department of Veterans Affairs, Richard L Roudebush Medical Center, Indianapolis, IN 46202, USA
Genes Brain Behav 7:214-23. 2008We report here the confirmation of the quantitative trait locus for haloperidol-induced catalepsy on distal chromosome (Chr) 1. We determined that this quantitative trait locus was captured in the B6...
- Differential effects of cyclooxygenase inhibitors on haloperidol-induced catalepsyPattipati S Naidu
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
Prog Neuropsychopharmacol Biol Psychiatry 26:819-22. 2002..cyclooxygenase (COX) inhibitor, dose-dependently (5 and 10 mg/kg) antagonized the haloperidol-induced catalepsy in mice...
- Diurnal variations in lymphocyte subpopulations in lymphoid organs of rats with genetic catalepsy and Wistar ratsN G Panteleeva
Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk
Bull Exp Biol Med 137:288-90. 2004Parameters of the immune status of the thymus and spleen in rats with genetic catalepsy were lower compared to those in Wistar rats. Diurnal variations in cell subpopulations of lymphoid organs were different in animals of these strains...
- Gender-related differences in the effects of nitric oxide donors on neuroleptic-induced catalepsy in miceJ G P Pires
Departamento de Ciencias Fisiologicas, Centro Biomedico, Universidade Federal do Espirito Santo, Vitoria, ES, Brasil
Braz J Med Biol Res 36:239-45. 2003..and S-nitroso-N-acetylpenicillamine (SNAP), three pharmacologically different NO donors, on neuroleptic-induced catalepsy in 60- to 80-day-old male and female albino mice...
- Synthesis of some urea and thiourea derivatives of 3-phenyl/ethyl-2-thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidine and their antagonistic effects on haloperidol-induced catalepsy and oxidative stress in miceFaizul Azam
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Seventh October, Misurata, Libya
Eur J Med Chem 44:3889-97. 2009..All the compounds have been evaluated for their antiparkinsonian activity in catalepsy induced by haloperidol in mice...
- Design, synthesis and anti-Parkinsonian evaluation of 3-alkyl/aryl-8-(furan-2-yl)thiazolo[5,4-e][1,2,4]triazolo[1,5-c]pyrimidine-2(3H)-thiones against neuroleptic-induced catalepsy and oxidative stress in miceFaizul Azam
Laboratory of Medicinal Chemistry, Faculty of Pharmacy, University of Seventh October, Misurata, Libya
J Enzyme Inhib Med Chem 25:818-26. 2010..All of the compounds were found to be active in haloperidol-induced catalepsy and oxidative stress in mice...
- Buspirone improves 6-hydroxydopamine-induced catalepsy through stimulation of nigral 5-HT(1A) receptors in ratsAlireza M Nayebi
Drug Applied Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran
Pharmacol Rep 62:258-64. 2010..the effect of buspirone, as a partial agonist of 5-HT(1A) receptors, on 6-hydroxydopamine (6-OHDA)-induced catalepsy in male Wistar rats...
- Role of adenosine and N-methyl-D-aspartate receptors in mediating haloperidol-induced gene expression and catalepsyE H Chartoff
Program in Neurobiology and Behavior, University of Washington, Seattle, Washington, USA
J Pharmacol Exp Ther 291:531-7. 1999..An acute behavioral response to haloperidol is catalepsy, considered to be a rodent correlate of some of the immediate extrapyramidal motor side effects seen in humans...
- Effect of BR-16A (Mentat), a polyherbal formulation on drug-induced catalepsy in miceAnil Kumar
University Institute of Pharmaceutical Science, Panjab University, Chandigarh 160 014, India
Indian J Exp Biol 44:45-8. 2006..Neuroleptic-induced catalepsy has long been used as an animal model for screening drugs for Parkinsonism...
- Adenosine A2A receptor knockout mice are partially protected against drug-induced catalepsyM El Yacoubi
UMR 6036 CNRS, IFRMP 23, , Rouen, France
Neuroreport 12:983-6. 2001b>Catalepsy assessed using the bar test was measured in both adenosine A2A receptor knockout (A2AR KO) and wild-type (A2AR WT) mice submitted to acute administration of the dopamine D2 receptor antagonist haloperidol (0.5, 2, 4, 6 mg/kg i...
- Involvement of 5-hydroxytryptamine1A receptors in Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in miceNobuaki Egashira
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka, University, 8 19 1, Nanakuma, Fukuoka 814 0180, Japan
Eur J Pharmacol 550:117-22. 2006..the involvement of 5-hydroxytryptamine(1A) (5-HT(1A)) receptors in Delta(9)-tetrahydrocannabinol (THC)-induced catalepsy-like immobilization in mice. THC (10 mg/kg, i.p...
- Delta9-tetrahydrocannbinol accounts for the antinociceptive, hypothermic, and cataleptic effects of marijuana in miceS A Varvel
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
J Pharmacol Exp Ther 314:329-37. 2005..First, the effects of delta9-THC on analgesia, hypothermia, and catalepsy were compared with those of a marijuana extract with equated delta9-THC content after either i.v...
- Ecstasy counteracts catalepsy in rats, an anti-parkinsonian effect?Werner J Schmidt
Zoological Institute, Neuropharmacology, Mohlstrasse 54 1, University Tübingen, 72074 Tubingen, Germany
Neurosci Lett 330:251-4. 2002..From the supraadditive effect of the enantiomers it may be concluded that both enantiomers contribute to the antiparkinsonian effects at two different target sites...
- Evaluation of amphetamine-induced hyperlocomotion and catalepsy following long-acting risperidone administration in ratsGiorgio Marchese
CNR, Institute of Biomedical Technology, Sect Cagliari, Technological Park of Sardinia Sardegna Ricerche, Pula, Cagliari, Italy
Eur J Pharmacol 620:36-41. 2009..To ascertain this hypothesis, antagonism of amphetamine-induced hyperlocomotion and catalepsy were analyzed in rats for a period of 1-6 weeks following long-acting risperidone (20-60 mg/kg) injection...
- Dopamine D2 receptor occupancy predicts catalepsy and the suppression of conditioned avoidance response behavior in ratsM L Wadenberg
Section of Biopsychology, CAMH, University of Toronto, Canada
Psychopharmacology (Berl) 150:422-9. 2000..Patients showed a clinical response with > or = 65% D2 occupancy, but EPS only when D2 occupancy >78%. Catalepsy and the selective suppression of conditioned avoidance response (CAR) are often used as animal models to predict ..
- Effect of NR-ANX-C (a polyherbal formulation) on haloperidol induced catalepsy in albino miceVinod Nair
Department of Pharmacology, Kasturba Medical College, Mangalore, India
Indian J Med Res 126:480-4. 2007..In rodents, administration of haloperidol leads to the development of a behavioural state called catalepsy, in which the animal is not able to correct an externally imposed posture...
- Enhanced efficacy of both typical and atypical antipsychotic drugs by adjunctive alpha2 adrenoceptor blockade: experimental evidenceMarie Louise Wadenberg
Department of Physiology and Pharmacology, Section of Neuropsychopharmacology, Karolinska Institutet, Stockholm, Sweden
Int J Neuropsychopharmacol 10:191-202. 2007..olanzapine) antipsychotic drug, both lacking appreciable alpha2 adrenoceptor affinity, on (i) CAR; (ii) catalepsy; and (iii) DA output in the prefrontal cortex and the nucleus accumbens using microdialysis...
- In vitro and in vivo characterization of F-97013-GD, a partial 5-HT1A agonist with antipsychotic- and antiparkinsonian-like propertiesArturo Zazpe
Department of Research, FAES FARMA, S A, Máximo Aguirre 14, 48940 Leioa, Vizcaya, Spain
Neuropharmacology 51:129-40. 2006..In addition, only high doses of F-97013-GD induced catalepsy in rodents and, like 8-OH-DPAT and clozapine, the compound reversed the haloperidol-induced catalepsy in rats...
- Effects of Ipomoea carnea aqueous fraction intake by dams during pregnancy on the physical and neurobehavioral development of rat offspringA Schwarz
Department of Pathology, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Av Prof Dr Orlando Marques de Paiva, 87, CEP 05508 900, Sao Paulo, Sao Paulo, Brazil
Neurotoxicol Teratol 25:615-26. 2003..The physical and reflex developmental parameters, open-field, plus-maze, social interaction, forced swimming, catalepsy and stereotyped behaviors, as well as striatal, cortical and hypothalamic monoamine levels (at 140 days of age) ..
- Some behavioural effects of carbamazepine - comparison with haloperidolE Nowakowska
Department of Pharmacoeconomics and Social Pharmacy, Karol Marcinkowski University of Medical Sciences, Poznan, Poland
J Physiol Pharmacol 58:253-64. 2007..CBZ did not induce catalepsy after single as well as chronic administration...
- Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal modelsSridhar Natesan
Schizophrenia Program and the PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
Neuropsychopharmacology 31:1854-63. 2006..Haloperidol and risperidone induced catalepsy at doses producing >80% D2RO, while aripiprazole despite higher D2RO (>90%) induced no catalepsy...
- Catalepsy intensifies context-dependently irrespective of whether it is induced by intermittent or chronic dopamine deficiencyA Klein
Zoological Institute, Neuropharmacology, University of Tuebingen, Germany
Behav Pharmacol 14:49-53. 2003It is well known that neuroleptic-induced catalepsy in rats intensifies upon repeated testing...
- Pharmacological actions of a novel and selective dopamine D3 receptor antagonist, KCH-1110Woo Kyu Park
Pharmaceutical Screening Research Team, Korea Research Institute of Chemical Technology, 100 Jang Dong, Yusong gu, Daejon 305 343, South Korea
Pharmacol Res 48:615-22. 2003..KCH-1110 did not induce catalepsy in mice, but at much higher doses only a slight catalepsy response was shown...
- A role for presynaptic mechanisms in the actions of nomifensine and haloperidolP A Garris
Cellular and Integrative Physiology Section, Department of Biological Sciences, Illinois State University, Normal, IL 61790 4120, USA
Neuroscience 118:819-29. 2003..effects on dopaminergic signaling and produce the dopamine (DA)-related behaviors of motor activation and catalepsy, respectively...
- Effects of tryptophan and valine administration on behavioral pharmacology of haloperidolObaid Ali
Central Drugs Laboratory, Ministry of Health, Government of Pakistan, Pakistan
Pak J Pharm Sci 18:23-8. 2005..and a large neutral amino acid other than tryptophan (valine) on the modulation of haloperidol induced catalepsy and akinesia...
- Aripiprazole, an atypical antipsychotic, prevents the motor hyperactivity induced by psychotomimetics and psychostimulants in miceJuliana V Leite
Department of Pharmacology, Ribeirao Preto School of Medicine, University of São Paulo Av Bandeirantes 3900, Ribeirao Preto SP, 14049 900, Brazil
Eur J Pharmacol 578:222-7. 2008..Independent groups also received aripiprazole (0.1-1 mg/kg) or haloperidol (0.5 mg/kg) and were tested for catalepsy. All doses of aripiprazole were effective in preventing the motor stimulant effects of amphetamine and cocaine...
- Effects of group I metabotropic glutamate receptors blockade in experimental models of Parkinson's diseaseAndrzej Dekundy
Preclinical R and D, Merz Pharmaceuticals GmbH, Eckenheimer Landstr 100, 60318 Frankfurt am Main, Germany
Brain Res Bull 69:318-26. 2006..EMQMCM), in animal studies indicative of antiparkinsonian-like activity such as haloperidol-induced catalepsy, hypoactivity in open field following haloperidol, and rotation in rats with unilateral 6-hydroxydopamine(OHDA)-..
- ACP-103, a 5-hydroxytryptamine 2A receptor inverse agonist, improves the antipsychotic efficacy and side-effect profile of haloperidol and risperidone in experimental modelsLuis R Gardell
ACADIA Pharmaceuticals, Inc, 3911 Sorrento Valley Blvd, San Diego, CA 92121, USA
J Pharmacol Exp Ther 322:862-70. 2007..ACP-103 also attenuated catalepsy produced by haloperidol or risperidone...
- Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosisJudith A Siuciak
CNS Discovery, MS 8220 4142, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
Neuropharmacology 51:386-96. 2006..In rats, papaverine potentiates haloperidol-induced catalepsy, consistent with the hypothesis that inhibition of PDE10A can increase striatal output and prompting a further ..
- Pharmacological profiles in rats of novel antipsychotics with combined dopamine D2/serotonin 5-HT1A activity: comparison with typical and atypical conventional antipsychoticsLaurent Bardin
Division of Neurobiology, Pierre Fabre Research Centre, Castres, France
Behav Pharmacol 18:103-18. 2007..Propensity to induce catalepsy, predictive of occurrence of extrapyramidal side effects, was inversely related to affinity at 5-HT1A receptors...
- Contrasting loxapine to its isomer isoloxapine--the critical role of in vivo D2 blockade in determining atypicalitySridhar Natesan
Schizophrenia PET program, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
Schizophr Res 77:189-99. 2005..The purpose of this study was to systematically compare the two drugs in in vitro and in vivo animal models, and to understand mechanisms underlying their differential typical/atypical profiles...
- Aripiprazole and its human metabolite are partial agonists at the human dopamine D2 receptor, but the rodent metabolite displays antagonist propertiesMartyn D Wood
Psychiatry Centre for Excellence in Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
Eur J Pharmacol 546:88-94. 2006....
- Reversal of haloperidol-induced extrapyramidal symptoms by buspirone: a time-related studyDarakhshan Jabeen Haleem
Department of Biochemistry, Neurochemistry and Biochemical Neuropharmacology Research Laboratory, University of Karachi, Karachi, Pakistan
Behav Pharmacol 18:147-53. 2007..Prior administration of buspirone for 2 weeks may be of help in the improvement of extrapyramidal symptoms induced by antipsychotic drugs...
- Anticataleptic properties of alpha2 adrenergic antagonists in the crossed leg position and bar tests: differential mediation by 5-HT1A receptor activationMark S Kleven
Neurobiology II, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F 81106 Castres, France
Psychopharmacology (Berl) 177:373-80. 2005..improve the antipsychotic-like effects of neuroleptics and attenuate dopamine D(2) receptor antagonist-induced catalepsy. However, several alpha(2) adrenergic antagonists also display serotonin 5-HT(1A) receptor agonist activity, ..
- Streptozotocin-induced diabetes differentially modifies haloperidol- and gamma-hydroxybutyric acid (GHB)-induced catalepsyRajkumar J Sevak
Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
Eur J Pharmacol 517:64-7. 2005..Haloperidol and GHB produced catalepsy in control and diabetic rats; haloperidol was less potent in diabetic rats (D(50)=0...
- Decreased brain docosahexaenoic acid during development alters dopamine-related behaviors in adult rats that are differentially affected by dietary remediationBeth Levant
Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Mail Stop 1018, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
Behav Brain Res 152:49-57. 2004..Beginning at P56, rats were subjected to a battery of behavioral tests. Catalepsy induced by haloperidol (3mg/kg, i.p.) in deficient animals was 49% of that observed in control animals (P < 0...
- Haloperidol versus risperidone on rat "early onset" vacuous chewingGiorgio Marchese
Neuroscienze S c ar l, Via Palabanda 9, 09123, Cagliari, Italy
Behav Brain Res 149:9-16. 2004Similarly to acute rat catalepsy, "early onset" vacuous chewing movements (VCMs) induced by subchronic treatment with antipsychotic have recently been proposed as a model of human extrapyramidal symptoms...
- Neuroleptic-like effects of gamma-hydroxybutyrate: interactions with haloperidol and dizocilpineRajkumar J Sevak
Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
Eur J Pharmacol 483:289-93. 2004..Here, we examined the ability of GHB and haloperidol to induce catalepsy and to affect operant responding. When given alone, both compounds induced catalepsy and decreased response rate...
- Novel antipsychotic agents with 5-HT(1A) agonist properties: role of 5-HT(1A) receptor activation in attenuation of catalepsy induction in ratsMark S Kleven
Pierre Fabre Research Centre, Neurobiology 2 Division, 17 Ave Jean Moulin, 81106 Castres, France
Neuropharmacology 49:135-43. 2005Compounds possessing 5-HT(1A) agonist properties attenuate catalepsy induced by D(2) receptor blockade...
- Impairment of dopaminergic system function after chronic treatment with corticotropin-releasing factorEmanuela Izzo
Department of Neuropharmacology, CVN 12, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, California, CA 92037, USA
Pharmacol Biochem Behav 81:701-8. 2005....
- Intensification of cataleptic response in 6-hydroxydopamine-induced neurodegeneration of substantia nigra is not dependent on the degree of dopamine depletionJ Srinivasan
Zoological Institute, Neuropharmacology, University of Tuebingen, Tuebingen 72076, Germany
Synapse 51:213-8. 2004An intensification of catalepsy has been observed upon repeated testing in rats with permanent neurodegeneration of substantia nigra...
- Brain tyrosine depletion attenuates haloperidol-induced striatal dopamine release in vivo and augments haloperidol-induced catalepsy in the ratGeorge E Jaskiw
Psychiatry Service 116A B, Louis Stokes Cleveland VAMC, 10000 Brecksville Road, Brecksville, OH 44141, USA
Psychopharmacology (Berl) 172:100-7. 2004..Since the DA antagonist haloperidol (HAL) increases striatal DA release and induces catalepsy through its actions on striatal DA systems, it provides a useful paradigm to assess both neurochemical and ..
- Design and synthesis of trans-3-(2-(4-((3-(3-(5-methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SB-414796): a potent and selective dopamine D3 receptor antagonistGregor J Macdonald
GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK
J Med Chem 46:4952-64. 2003....
- Design, synthesis, and evaluation of the antipsychotic potential of orally bioavailable neurotensin (8-13) analogues containing non-natural arginine and lysine residuesM Kyle Hadden
Department of Pharmaceutical Sciences, Medical University of South Carolina, 280 Calhoun Street, PO Box 250140, Charleston, SC 29425, USA
Neuropharmacology 49:1149-59. 2005..Finally, KH28 did not produce catalepsy, a deleterious side-effect elicited by classical antipsychotic drugs...
- The acute EPS of haloperidol may be unrelated to its metabolic transformation to BCPP+Donald M N Sikazwe
College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, FL 32307, USA
Bioorg Med Chem Lett 13:3779-82. 2003..This study suggests that D2 affinity may be the primary underlying mechanism for acute catalepsy induction by haloperidol.
- Evaluation of N-desmethylclozapine as a potential antipsychotic--preclinical studiesSridhar Natesan
1Schizophrenia Program and the PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
Neuropsychopharmacology 32:1540-9. 2007..hyperlocomotion (AIL) and conditioned avoidance response (CAR) models); measures predictive of side effects (catalepsy and prolactin elevation); and molecular markers predictive of antipsychotic action (striatal Fos induction)...
- CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activityJudith A Siuciak
CNS Discovery, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
Neuropharmacology 52:279-90. 2007..At doses up to 56 mg/kg, CP-809,101 did not produce catalepsy. Thus, the present results demonstrate that the 5-HT(2C) agonist, CP-809,101, has a pharmacological profile ..
- Increasing D2 affinity results in the loss of clozapine's atypical antipsychotic actionShitij Kapur
Department of Psychiatry, University of Toronto, Toronto M5S 3H6, Canada
Neuroreport 13:831-5. 2002..When tested in a series of animal models indicative of the typical/atypical distinction (catalepsy, striatal gene-induction, prolactin elevation) isoclozapine lost atypical properties and behaved like a typical ..
- The neurosteroid 3 alpha-hydroxy-5 alpha-pregnan-20-one affects dopamine-mediated behavior in rodentsRahul T Khisti
Department of Pharmaceutical Sciences, Nagpur University Campus, Nagpur 440 010, Maharashtra, India
Psychopharmacology (Berl) 161:120-8. 2002The neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-THP) has been previously shown to induce catalepsy in mice that is modified by GABAergic, dopaminergic, adenosinergic and serotonergic agents...
- Central 5-HT(4) receptors and dopamine-dependent motor behaviors: searching for a functional rolePhilippe De Deurwaerdère
Laboratoire Neuropsychobiologie des Desadaptations, UMR CNRS 5541, Universite Victor Segalen Bordeaux 2, B P 31, 146 rue Leo Saignat, 33077 Cedex, Bordeaux, France
Pharmacol Biochem Behav 71:627-33. 2002..motor behaviors related to change of nigrostriatal dopamine (DA) transmission, namely, stereotyped behavior and catalepsy in rats...
- Neuroleptics and animal models: feasibility of oral treatment monitored by plasma levels and receptor occupancy assaysEmma Perez-Costas
Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, SPARKS Center SC865, Birmingham, AL 35294, USA
J Neural Transm 115:745-53. 2008....
- Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studiesGiuseppe Campiani
Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via Aldo Moro, 53100 Siena, Italy
J Med Chem 45:344-59. 2002..This atypical antipsychotic lead has low propensity to induce catalepsy in rat...
- Dysregulation of the mesolimbic dopamine system and reward in MCH-/- micePavlos Pissios
Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Biol Psychiatry 64:184-91. 2008....
- Possible involvement of prostaglandins in haloperidol-induced orofacial dyskinesia in ratsP S Naidu
Division of Pharmacology, University Institute of Pharmaceutical Sciences, Panjab University, 160014, Chandigarh, India
Eur J Pharmacol 430:295-8. 2001..Behavioural assessment of orofacial dyskinesia was done 24 h after the last dose of haloperidol. Catalepsy was induced in rats by acute treatment with haloperidol (1 mg/kg), and catalepsy was scored for the next 4 h...
- Mechanisms for metoclopramide-mediated sensitization and haloperidol-induced catalepsy in ratsMervan S Agovic
Department of Physiology and Pharmacology, The City University of New York, Medical School, New York, New York 10031, USA
Eur J Pharmacol 587:181-6. 2008..such as the dopamine D(2) receptor antagonist, haloperidol are known to cause movement disorders or catalepsy in experimental animals. Catalepsy is believed to result from blockade of dopamine D(2) receptors...
- Dosing time-dependent tolerance of catalepsy by repetitive administration of haloperidol in miceJ Viyoch
Department of Clinical Pharmacokinetics, Division of Pharmaceutical Sciences, Graduate School, Kyushu University, Higashi-ku, Fukuoka, Japan
J Pharmacol Exp Ther 298:964-9. 2001..p. at 9:00 AM or 9:00 PM, the time nearly corresponding to the maximal or minimal catalepsy responses to a single dose, respectively, for 14 days and catalepsy responses were monitored at 1 h after ..
- Effects of buspirone on dopamine dependent behaviours in ratsA G Dhavalshankh
Department of Pharmacology, Krishna Institute of Medical Sciences, Karad
Indian J Physiol Pharmacol 51:375-86. 2007..apomorphine in biochemical presynaptic nigrostriatal D2 DA autoreceptor test systems buspirone neither induced catalepsy nor antagonised apomorphine-induced turning behaviour in rats indicating that at these doses buspirone does not ..
- Feeding conditions differentially affect the neurochemical and behavioral effects of dopaminergic drugs in male ratsRajkumar J Sevak
Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, United States
Eur J Pharmacol 592:109-15. 2008..the dopamine receptor agonist quinpirole (yawning), and the dopamine receptor antagonist raclopride (catalepsy). Amphetamine increased locomotion and produced conditioned place preference...
- Behavioral and biochemical effects of amperozide and serotonin agents on nigrostriatal and mesolimbic dopamine systemsPu Yuan Chang
Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan, Republic of China
Chin J Physiol 51:106-15. 2008..Furthermore, DOI and amperozide, but not ritanserin, reduced the haloperidol-induced catalepsy. [corrected] When animals were unilaterally radiofrequency lesioned in either caudate putamen (CP) or nucleus ..
- Dopamine D2 long receptor-deficient mice display alterations in striatum-dependent functionsY Wang
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
J Neurosci 20:8305-14. 2000..Interestingly, haloperidol produced significantly less catalepsy and inhibition of locomotor activity in D2L-/- mice...
- Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6-hydroxydopamine-induced partial degeneration of substantia nigra in ratsJ Srinivasan
Zoological Institute, Neuropharmacology, University of Tuebingen, Auf der Morgenstelle 28E, 72076, Tuebingen, Germany
Eur J Neurosci 17:2586-92. 2003..Behaviour was evaluated by catalepsy tests and activity box...
- [Neuroleptic-like activity of the tripeptide neurotensin analog GZR-123]L S Guzevatykh
Laboratory of Psychopharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul 8, Moscow, 125315 Russia
Eksp Klin Farmakol 65:3-6. 2002..At a dose 1250 times the ED50 for apomorphine and L-DOPA dependent tests, GZR-123 did not cause acute toxicity and did not provoke catalepsy.
- Nootropic activity of Albizzia lebbeck in miceS D Chintawar
Department of Pharmacology, M V P Samaj s College of Pharmacy, Nashik 422 002, Maharashtra, India
J Ethnopharmacol 81:299-305. 2002..The brain concentrations of GABA and dopamine were decreased, whereas the 5-HT level was increased. The data indicate the involvement of monoamine neurotransmitters in the nootropic action of BF of A. lebbeck...
- Effects of dopamine receptor blockade on cerebral blood flow response to somatosensory stimulation in the unanesthetized ratTakanori Esaki
Laboratory of Cerebral Metabolism, National Institute of Mental Health NIH, Building 36, 36 Convent Drive, Bethesda, MD 20892 4030, USA
J Pharmacol Exp Ther 303:497-502. 2002..These results do not support a role for direct dopaminergic vasoactive mechanisms in the increases in CBF associated with neuronal functional activation...
- Dopamine D3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in ratsStanislav R Vorel
Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
J Neurosci 22:9595-603. 2002....
- Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 2: asymmetric synthesis and biological evaluationHe Zhao
Neurogen Corporation, 35Northeast Industrial Road, Branford, CT 06405, USA
Bioorg Med Chem Lett 12:3111-5. 2002..Three compounds having D(2)/D(4) affinity ratios approximating that found for the atypical neuroleptic clozapine were further evaluated in behavioral tests of antipsychotic efficacy and motor side effects...
- In vitro and in vivo pharmacological profile of 4-(4-fluorobenzylidene)-1-[2-[5-(4-fluorophenyl)-1H-pyrazol-4-yl] ethyl] piperidine (NRA0161)Yoshiko Suzuki
Molecular Biology Laboratory, Taisho Pharmaceutical Co, Ltd, 1 403 Yoshino cho, Saitama shi, Saitama, 330 8530, Japan
Life Sci 71:2603-15. 2002..antagonized the MAP-induced stereotyped behavior in mice and NRA0161 dose-dependently and significantly induced catalepsy in rats...
- Effects of dextromethorphan on dopamine dependent behaviours in ratsR V Gaikwad
Department of Pharmacology, Krishna Institute of Medical Sciences, Karad 415 110, India
Indian J Exp Biol 45:712-9. 2007..5-75 mg/kg, ip did not induce oral stereotypies or catalepsy and did not antagonize apomorphine stereotypy in rats. These results indicate that dextromethorphan at 7...
- Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, potentiates neurochemical and behavioral effects of haloperidol in the ratCatherine Pillot
Laboratoire de Physiologie, Faculte des Sciences Pharmaceutiques et Biologiques, 75006 Paris, France
J Neurosci 22:7272-80. 2002..any motor effect when used alone, ciproxifan strongly potentiated haloperidol-induced locomotor hypoactivity and catalepsy, two behaviors in which striatal neurons are involved...
- The differential effect of haloperidol and repetitive induction on four immobility responses in mouse and guinea pigT Fregoso-Aguilar
Department of Physiology, National School of Biological Sciences, National Polytechnic Institute, Mexico
Behav Pharmacol 13:253-60. 2002....
- Cyclooxygenase inhibitor modulation of dopamine-related behavioursBrian M Ross
Highland Psychiatric Research Foundation, UHI Millennium Institute, The Greenhouse, Beechwood Business Park North, Inverness, Scotland IV2 3ED, UK
Eur J Pharmacol 450:141-51. 2002..Both drugs inhibited catalepsy induced by the dopamine D1-like receptor antagonist R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-..
- Genetics and Haloperidol ResponseRobert J Hitzemann; Fiscal Year: 2012..two QTLs found on chromosomes 1 and 14 and which have been repeatedly shown to be associated with the catalepsy response...
- CB1 Receptor Regulation by Cannabinoid Receptor Interacting Protein CRIP1aDANA E contact SELLEY; Fiscal Year: 2010..effects of the knockout on the pharmacological potency of CB agonists in tests of hypothermia, hypolocomotion, catalepsy and antinociception...
- Dorsal Column Stimulation as a New Therapy for Motor DisordersMiguel A L Nicolelis; Fiscal Year: 2013..Open field activity, catalepsy tests and rotating rod tests will be used to evaluate their motor function and compare it to a sham treated ..
- CB1 and DA Receptor Deletion by RNAi in Cocaine Self-AdministrationCAROLINE EVELYN BASS; Fiscal Year: 2011..and medulla and assessing the efficacy of THC in inducing antinociception, hypoactivity, hypothermia, and catalepsy;3) delineate and define the contribution of D1 and D2 receptors in the ventral striatum, dorsal striatum and VTA ..
- Design of New Therapeutic Agents to Treat SchizophreniaJames M Cook; Fiscal Year: 2013..to reverse the cognitive symptoms of schizophrenia in the PPI model of PCP treated rats but induced no signs of catalepsy. Under specific aims 2 and 3, synthetic routes to generate the proposed compounds are already establish and ..
- Candidate Medications for Cannabis Addiction: FAAH InhibitorsAlexandros Makriyannis; Fiscal Year: 2013..receptor binding, plasma and microsomal stability) and in vivo endpoints (brain penetrability, hypothermia, catalepsy, and drug discrimination) to identify novel FAAH inhibitors as 'lead'compounds...
- Novel Neurotensin Analogs as AntischizophrenicsThomas A Dix; Fiscal Year: 2012..This compound showed strong efficacy in the key rat models of psychosis, did not cause catalepsy, and animals did not develop resistance to it...
- Evaluating BMY-14802 as an anti-dyskinesia treatment in the 6-OHDA rat model of PMELANIE PAQUETTE; Fiscal Year: 2009..Antagonism of the D2 receptor is observed behaviorally as catalepsy, a slowness to move out of awkward positions...
- CANNABINOIDS AND THE HYPOTHALAMIC-PITUITARY-ADRENAL AXISLaura Murphy; Fiscal Year: 2002..Furthermore, the role of CRH in the ability of cannabinoids to decrease luteinizing hormone (LH) and induce catalepsy and alterations in feeding behavior will be investigated...
- DRUG SELF ADMINISTRATION IN MOUSE MODELS OF NEUROAIDSLisa Gold; Fiscal Year: 1999..drug probes in tasks assessing learning (nonconditional spatial discrimination), motor activity (locomotion, catalepsy), and analgesia...
- EFFECTS OF ACUTE BENZODIAZEPINE GROWING WITH TIMESEYMOUR ANTELMAN; Fiscal Year: 1990..same dose readministered two weeks later; 2) one injection of diazepam significantly sensitizes both haloperidol catalepsy and ptosis two weeks but not two hours later; 3) a single injection of saline 1 month earlier completely ..
- CANNABIDIOL--EFFECT ON CYTOCHROME P450 ISOZYMESLester Bornheim; Fiscal Year: 2000..THC) and its metabolites and metabolite half-times in the brain, but also increase the duration of THC-induced catalepsy. CBD pretreatment also increases brain levels of cocaine as well as acute cocaine-induced seizure activity and ..
- BIOLOGICAL ACTIVITIES OF CANNABINOIDSSumner Burstein; Fiscal Year: 1993..pair, will be measured and compared with tissue levels of eicosanoids and with biological endpoints such as catalepsy, analgesia and anti-edema effects...
- DOPAMINE AGONISTS FOR THE THERAPY OF COCAINE ADDICTIONJOHN NEUMEYER; Fiscal Year: 1999..a primate species and to further evaluate agonist efficacy in behavioral assays of eyeblinking and reversal of catalepsy induced by dopamine D1 receptor blockade, This research is expected to result in one or more dopamine D1 partial ..
- ELECTROPHYSIOLOGY OF CANNABINOID ACTION ON RAT BEHAVIORSJing Yu Chang; Fiscal Year: 2001..addition, the effect of different doses of cannabinoid on spontaneous locomotor activity (from hyper-activity to catalepsy in response to different does of cannabinoid) will be investigated...
- MECHANISM OF ACTION OF CANNABISSumner Burstein; Fiscal Year: 1991..are proposed which will attempt to show a casual relationship between THC-induced prostaglandin changes and catalepsy and/or motor toxicity in the mouse...
- Developmental Psychopharmacology of AntipsychoticsJENNY WILEY; Fiscal Year: 2007..subsequently, they will be evaluated in behavioral procedures designed to measure motor activity (locomotion and catalepsy)...
- Neuropharmacology of GHB discriminationWouter Koek; Fiscal Year: 2010..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
- Discriminative Stimulus Effects of Alcohol in MiceWouter Koek; Fiscal Year: 2007..This future research will increase our understanding of risk factors for alcoholism and drug abuse and will help the development of effective approaches to prevention and treatment. [unreadable] [unreadable] [unreadable]..
- "Post-partum steroid withdrawal-induced depression"REBECCA CRAFT; Fiscal Year: 2006..Findings from the proposed model will enhance our understanding of the etiology of PPD and possibly lead to improved treatment options. ..
- Brain Cannabinoid Signaling: Selectivity and AdaptationLaura J Sim Selley; Fiscal Year: 2010..regulates acute and chronic CB1R signaling, THC-mediated in vivo effects (antinociception, locomotor inhibition, catalepsy, hypothermia) and tolerance...
- Drug Abuse Related Polymorphism in Fatty Acid Amide HydrolaseBenjamin Cravatt; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Mechanisms of Amphetamine Action on Dopaminergic SignalingPAUL GARRIS; Fiscal Year: 2007..New microsensor technology will be employed in laboratory animals to characterize amphetamine's effect on brain chemistry related to learning and motivaton. [unreadable] [unreadable] [unreadable]..
- NEUROPEPTIDERGIC CONTROL OF MATERNAL BEHAVIORBENJAMIN NEPHEW; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- CB-1 Antagonists for Cannabis AddictionJack Bergman; Fiscal Year: 2008..neutral antagonism will be studied in rats to confirm their biological activity as antagonists of CB-1 induced catalepsy and to separate active compounds on the basis of the duration of their behavioral effects...
- METABOTROPIC GLUTAMATE RECEPTORS IN BASAL GANGLIACOLLEEN NISWENDER; Fiscal Year: 2009..Furthermore, we will test the hypothesis that agonists or allosteric potentiators of this receptor can provide palliative relief in rodent models of PD by actions in the GP. ..
- Enzymes That Regulate Fatty Acid Amide Function In VivoBenjamin Cravatt; Fiscal Year: 2009..These studies will elucidate the functions of key enzymes that regulate FAA signaling in vivo. These proteins may represent new targets for the treatment of pain, addiction, and other neurological disorders. ..
- Pharmacotherapy of Cannabinoid Withdrawal: Pre-Clinical StudiesLance R McMahon; Fiscal Year: 2010..Collectively, these specific aims provide a framework for developing novel pharmacotherapies of marijuana withdrawal that could markedly decrease marijuana use and dependence. ..
- BEHAVIORAL EFFECTS AND ABUSE OF DOPAMINERGIC DRUGSJack Bergman; Fiscal Year: 2007..This research should point to novel directions for the development of medications with which to manage the abuse and addictive liabilities of psychomotor stimulant drugs ..
- CONTROL OF ENDOCANNABINOID RELEASE IN VIVODaniele Piomelli; Fiscal Year: 2003..Moreover, by uncovering the neurochemical interactions between cocaine and the endogenous cannabinoids, our studies will contribute to the general understanding of substance abuse and neuropsychiatric disorders. ..
- Multiple Factors Affecting Placebo Response in PDChristopher Goetz; Fiscal Year: 2004..Defining these determinant influences will help enhance placebo responses in clinical practice and control them in clinical trials. ..
- Feto-Maternal Pharmacokinetics of Abused InhalantsSTEPHEN DEWEY; Fiscal Year: 2004..Ultimately, the hope is to relate the mother's exposure to inhalants to the dose received by the fetus and to post-natal behavioral deficits. ..
- Drug discrimination and THC withdrawal in monkeysLANCE MCMAHON; Fiscal Year: 2005..abstract_text> ..
- Antipsychotic-Like Drug Effects of NeurotensinDavid Feifel; Fiscal Year: 2004....
- STRUCTURE/FUNCTION STUDIES OF FATTY ACID AMIDE HYDROLASEBenjamin Cravatt; Fiscal Year: 2004..abstract_text> ..
- MOTOR EFFECTS OF ATYPICAL ANTIPSYCHOTICSJohn Salamone; Fiscal Year: 2003..Taken together, the results of these experiments will help to identify the pharmacological characteristics and brain circuits that underlie the motor effects of clozapine. ..
- PALLIDAL GABA AND ATYPICALITY OF ANTIPSYCHOTIC DRUGSRONALD SEE; Fiscal Year: 2002..The information obtained will facilitate the development of optimal pharmacotherapy for mental disorders, particularly schizophrenia. ..
- BEHAVIORAL EFFECTS OF NIGRAL D1 ANTAGONISMJohn Salamone; Fiscal Year: 2001....
- 2006 Genes & Behavior ConferenceRobert Hitzemann; Fiscal Year: 2006..We believe the second conference will be even more successful than the first. [unreadable] [unreadable] [unreadable]..
- Brain LC-PUFAs and Maternal Mental HealthBeth Levant; Fiscal Year: 2006..These findings will also suggest novel treatments for such illnesses when they occur. ..
- MOTOR ACTIONS OF CANNABINOIDS IN A PARKINSONS MODELCLARA SANUDO PENA; Fiscal Year: 2002..Behavioral, biochemical, and physiological studies will be conducted in parallel to test this possibility. It will also help integrate the cannabinergic system with the current knowledge of basal ganglia physiology. ..
- Cocaine Addiction:Medication Strategies and EvalutionJack Bergman; Fiscal Year: 2006..abstract_text> ..
- Measurement of GPCR-mediated thallium flux:GIRK (RMI)COLLEEN NISWENDER; Fiscal Year: 2005..Identified compounds will provide new pharmacological tools to test the role of the ?2C adrenergic receptor in psychiatric and cardiovascular disorders and the role of GIRK 1/2 channels in the modulation of neuronal excitability. ..
- DOPAMINE NEUROTRANSMISSION IN EXPERIMENTAL PARKINSONISMPAUL GARRIS; Fiscal Year: 2005..Moreover, L-DOPA is associated with adverse side effects after extended use, apparently due to non-physiological dopamine replacement. However, how L-DOPA acts on dopaminergic signaling is not completely established. ..
- Translational Genetic Study of Fear and AnxietyABRAHAM PALMER; Fiscal Year: 2007..This training program will prepare the candidate for an academic career focused on the use of endophenotypes, animal models and bioinformatics to elucidate the genetic basis of psychiatric disease. [unreadable] [unreadable]..
- Characterization of a novel brain cannabinoid ligandDaniele Piomelli; Fiscal Year: 2010..The objective of our research is to understand how these transmitters are produced and eliminated, and discover innovative medicines that target these processes. ..
- Cellular Mechanisms for Oligodendrocyte MyelinationBruce D Trapp; Fiscal Year: 2010..Collectively, these studies should identify therapeutic targets that enhance remyelination and reduce the progression of neurological disability in MS patients. ..
- Dopamine D2 and Adenosine A2A roles:Tremulous MovementsJohn Salamone; Fiscal Year: 2007..abstract_text> ..
- Role of oleoylethanolamide in the control of food intakeDaniele Piomelli; Fiscal Year: 2010....
- Brain DHA, Dopamine, and Behavior: Roles in ADHDBeth Levant; Fiscal Year: 2006..Such insights may identify a means by which certain risk factors for ADHD may be reduced or eliminated or the severity of the disease may be reduced through appropriate pre- and postnatal nutrition. [unreadable] [unreadable]..
- Microarray Platform for Profiling Cancer ProteasesBenjamin Cravatt; Fiscal Year: 2008..These proteases may in turn represent valuable new markers and targets for the diagnosis and treatment of cancer. ..
- CHEMICAL APPROACHES FOR ACTIVITY BASED PROTEOMICSBenjamin Cravatt; Fiscal Year: 2008..unreadable] [unreadable]..
- Assay for HTS of Gi/Go-linked GPCRs: mGluR7 as Prot(RMI)COLLEEN NISWENDER; Fiscal Year: 2007..abstract_text> ..
- MOLECULAR MECHANISMS OF SCHWANN CELL MYELINATIONBruce Trapp; Fiscal Year: 2008....
- Role of Endocannabinoids in the Behavioral Consequences of Social IsolationDaniele Piomelli; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Chronic Cannabinoids, Tumor Growth and HyperalgesiaDARRYL HAMAMOTO; Fiscal Year: 2005..Positive results from these studies would suggest that cannabinoids could be useful for the treatment of cancer pain. ..
- Oleylethanolamide derivatives as anti-obesity agentsDaniele Piomelli; Fiscal Year: 2005....
- Effort-related Functions of Nucleus Accumbens Adenosine A2A ReceptorsJohn D Salamone; Fiscal Year: 2010....
- A Novel Animal Model of Relevance to SchizophreniaDavid Feifel; Fiscal Year: 2009..The successful development of this animal model could significantly enhance the understanding of the underlying causes of schizophrenia-associated abnormalities and improve drug discovery. ..