catalepsy

Summary

Summary: A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. The limbs tend to remain in whatever position they are placed (waxy flexibility). Catalepsy may be associated with PSYCHOTIC DISORDERS (e.g., SCHIZOPHRENIA, CATATONIC), nervous system drug toxicity, and other conditions.

Top Publications

  1. ncbi Glutamatergic neurotransmission mediated by NMDA receptors in the inferior colliculus can modulate haloperidol-induced catalepsy
    L L Melo
    Laboratorio de Neuropsicofarmacologia, Universidade São Francisco, Av São Francisco de Assis, 218, Braganca Paulista, SP, 12916 900, Brasil
    Brain Res 1349:41-7. 2010
  2. ncbi BL-1020: a novel antipsychotic drug with GABAergic activity and low catalepsy, is efficacious in a rat model of schizophrenia
    Yona Geffen
    BioLineRx Ltd, 19 Hartum Street, Jerusalem, Israel
    Eur Neuropsychopharmacol 19:1-13. 2009
  3. ncbi Gene networks and haloperidol-induced catalepsy
    O D Iancu
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA
    Genes Brain Behav 11:29-37. 2012
  4. ncbi Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy
    Kenneth J Valenzano
    Department of Pharmacology, Purdue Pharma Discovery Research, Cranbury, NJ 08512, USA
    Neuropharmacology 48:658-72. 2005
  5. ncbi Caffeine and muscarinic antagonists act in synergy to inhibit haloperidol-induced catalepsy
    Rosa E Moo-Puc
    Laboratorio de Neurofisiologia, Centro de Investigaciones Regionales, Dr Hideyo Noguchi, Universidad Autonoma de Yucatan, Avenida Itzaes No 490, Merida, Yucatan 97000, Mexico
    Neuropharmacology 45:493-503. 2003
  6. ncbi A new synthetic varacin analogue, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153), decreased hereditary catalepsy and increased the BDNF gene expression in the hippocampus in mice
    Alexander V Kulikov
    Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia
    Psychopharmacology (Berl) 221:469-78. 2012
  7. pmc Differential network analysis reveals genetic effects on catalepsy modules
    Ovidiu D Iancu
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
    PLoS ONE 8:e58951. 2013
  8. ncbi 5-HT1A receptor activation and anti-cataleptic effects: high-efficacy agonists maximally inhibit haloperidol-induced catalepsy
    Eric P M Prinssen
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F 81106 Cedex, Castres, France
    Eur J Pharmacol 453:217-21. 2002
  9. ncbi Cannabidiol attenuates catalepsy induced by distinct pharmacological mechanisms via 5-HT1A receptor activation in mice
    Felipe V Gomes
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, Ribeirao Preto, SP, 14049 900, Brazil Center for Interdisciplinary Research on Applied Neurosciences NAPNA, University of Sao Paulo, Brazil Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 46:43-7. 2013
  10. ncbi Dopaminergic mechanisms underlying catalepsy, fear and anxiety: do they interact?
    Ana Caroline Colombo
    Laboratorio de Psicobiologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil Instituto de Neurociências e Comportamento INeC, Ribeirao Preto, SP, Brazil
    Behav Brain Res 257:201-7. 2013

Detail Information

Publications222 found, 100 shown here

  1. ncbi Glutamatergic neurotransmission mediated by NMDA receptors in the inferior colliculus can modulate haloperidol-induced catalepsy
    L L Melo
    Laboratorio de Neuropsicofarmacologia, Universidade São Francisco, Av São Francisco de Assis, 218, Braganca Paulista, SP, 12916 900, Brasil
    Brain Res 1349:41-7. 2010
    ..The present study examined the influence of excitatory amino acid-mediated mechanisms in the IC on the catalepsy induced by the dopamine receptor blocker haloperidol administered systemically (1 or 0.5 mg/kg) in rats...
  2. ncbi BL-1020: a novel antipsychotic drug with GABAergic activity and low catalepsy, is efficacious in a rat model of schizophrenia
    Yona Geffen
    BioLineRx Ltd, 19 Hartum Street, Jerusalem, Israel
    Eur Neuropsychopharmacol 19:1-13. 2009
    ..Oral BL-1020 or perphenazine were assessed in acute and subchronic schizophrenia rat models. Catalepsy, serum prolactin, receptor binding profile and cortical (PFC), hippocampal (Hip) and dopamine (DA) levels were ..
  3. ncbi Gene networks and haloperidol-induced catalepsy
    O D Iancu
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA
    Genes Brain Behav 11:29-37. 2012
    ..These results suggest that a network-based strategy will help identify the genetic factors associated with haloperidol response...
  4. ncbi Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy
    Kenneth J Valenzano
    Department of Pharmacology, Purdue Pharma Discovery Research, Cranbury, NJ 08512, USA
    Neuropharmacology 48:658-72. 2005
    ..However, activation of CB1 receptors is also associated with central side effects, including ataxia and catalepsy. More recently, a role for selective CB2 agonists in pain modification has been demonstrated...
  5. ncbi Caffeine and muscarinic antagonists act in synergy to inhibit haloperidol-induced catalepsy
    Rosa E Moo-Puc
    Laboratorio de Neurofisiologia, Centro de Investigaciones Regionales, Dr Hideyo Noguchi, Universidad Autonoma de Yucatan, Avenida Itzaes No 490, Merida, Yucatan 97000, Mexico
    Neuropharmacology 45:493-503. 2003
    The possible synergism between caffeine and muscarinic antagonists to inhibit haloperidol-induced catalepsy was investigated with the bar test in rats...
  6. ncbi A new synthetic varacin analogue, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153), decreased hereditary catalepsy and increased the BDNF gene expression in the hippocampus in mice
    Alexander V Kulikov
    Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia
    Psychopharmacology (Berl) 221:469-78. 2012
    ..The creation of effective psychotropic drugs is the key problem of psychopharmacology. Natural compounds and their synthetic analogues attract particular attention...
  7. pmc Differential network analysis reveals genetic effects on catalepsy modules
    Ovidiu D Iancu
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
    PLoS ONE 8:e58951. 2013
    We performed short-term bi-directional selective breeding for haloperidol-induced catalepsy, starting from three mouse populations of increasingly complex genetic structure: an F2 intercross, a heterogeneous stock (HS) formed by crossing ..
  8. ncbi 5-HT1A receptor activation and anti-cataleptic effects: high-efficacy agonists maximally inhibit haloperidol-induced catalepsy
    Eric P M Prinssen
    Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F 81106 Cedex, Castres, France
    Eur J Pharmacol 453:217-21. 2002
    Studies have shown that 5-HT1A receptor ligands modulate antipsychotic-induced catalepsy. Here, we further examined the role of intrinsic activity at 5-HT1A receptors in these effects...
  9. ncbi Cannabidiol attenuates catalepsy induced by distinct pharmacological mechanisms via 5-HT1A receptor activation in mice
    Felipe V Gomes
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, Ribeirao Preto, SP, 14049 900, Brazil Center for Interdisciplinary Research on Applied Neurosciences NAPNA, University of Sao Paulo, Brazil Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 46:43-7. 2013
    ..To investigate this possibility we evaluated if CBD would prevent catalepsy induced by drugs with distinct pharmacological mechanisms...
  10. ncbi Dopaminergic mechanisms underlying catalepsy, fear and anxiety: do they interact?
    Ana Caroline Colombo
    Laboratorio de Psicobiologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil Instituto de Neurociências e Comportamento INeC, Ribeirao Preto, SP, Brazil
    Behav Brain Res 257:201-7. 2013
    Haloperidol is a dopamine D2 receptor antagonist that induces catalepsy when systemically administered to rodents. The haloperidol-induced catalepsy is a state of akinesia and rigidity very similar to that seen in Parkinson's disease...
  11. ncbi Modulation of haloperidol-induced catalepsy in rats by GABAergic neural substrate in the inferior colliculus
    J G Tostes
    Laboratorio de Neuropsicofarmacologia, Universidade São Francisco, Avenida São Francisco de Assis, 218, Braganca Paulista, SP 12916 900, Brazil Faculdade de Medicina de Itajubá, Avenida Renó Júnior, 368, São Vicente, Itajuba, MG 37502 138, Brazil
    Neuroscience 255:212-8. 2013
    ..the IC to motor behavior shows that glutamate-mediated mechanisms within the IC modulate haloperidol-induced catalepsy. The high density of GABAergic receptors in the IC led to this study of a possible link between these receptors, ..
  12. ncbi Haloperidol catalepsy consolidation in the rat as a model of neuromodulatory integration
    A S Bazyan
    Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia
    Neuroscience 99:279-88. 2000
    ..Haloperidol administration (2.5 mg/kg i.p.) evoked catalepsy and increased the content of noradrenaline and dopamine in the same structures of the brain...
  13. ncbi Modulation by female sex hormones of the cannabinoid-induced catalepsy and analgesia in ovariectomized mice
    Dina Kalbasi Anaraki
    Department of Pharmacology, School of Medicine, Medical Sciences University of Tehran, P O Box 13145 784, Tehran, Iran
    Eur J Pharmacol 586:189-96. 2008
    Cannabinoids are psychoactive compounds with many pharmacological properties such as analgesia, sedation and catalepsy most of which are mediated by cannabinoid CB1 receptors...
  14. pmc The neurotensin-1 receptor agonist PD149163 inhibits conditioned avoidance responding without producing catalepsy in rats
    Elizabeth N Holly
    Psychology Department, Northern Michigan University, 1401 Presque Isle Ave, Marquette, Michigan, USA
    Eur Neuropsychopharmacol 21:526-31. 2011
    ..0 or 8.0 mg/kg dose. PD149163 failed to significantly increase catalepsy scores. The typical antipsychotic drug haloperidol (0.01-1.0 mg/kg) significantly suppressed CAR at a 0.1, 0...
  15. ncbi Identification of quantitative trait loci for haloperidol-induced catalepsy on mouse chromosome 14
    E Rasmussen
    Department of Psychiatry and Psychology, State University of New York at Stony Brook, Stony Brook, New York, USA
    J Pharmacol Exp Ther 290:1337-46. 1999
    Previous studies have established that neuroleptic-induced catalepsy in mice is a highly heritable trait...
  16. ncbi Haloperidol-induced catalepsy is absent in dopamine D(2), but maintained in dopamine D(3) receptor knock-out mice
    D Boulay
    Department of Psychopharmacology, Sanofi Synthelabo, 31 Ave P Vaillant Couturier, 92220, Bagneux, France
    Eur J Pharmacol 391:63-73. 2000
    ..mice homozygous for the deletion of the dopamine D(2) receptor gene (D(2)(-/-) mice) do not present spontaneous catalepsy when tested in a "bar test"...
  17. ncbi Neuroleptic-induced catalepsy: electrophysiological mechanisms of functional recovery induced by high-frequency stimulation of the subthalamic nucleus
    Bertrand Degos
    Institut National de la Santé et de la Recherche Médicale Unité 667, College de France, 75231 Paris Cedex 05, France
    J Neurosci 25:7687-96. 2005
    ..receptors, respectively, were performed, and the parameters of STN HFS that reversed the neuroleptic-induced catalepsy were determined in freely moving animals...
  18. pmc Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications
    Giorgio Marchese
    Neuroscienze S c a r l, Cagliari 09123, Italy
    Br J Pharmacol 140:520-6. 2003
    The effect on rat catalepsy induced by Delta9-tetrahydrocannabinol (Delta9-THC) in association with haloperidol (HP) or clozapine (CLOZ) administration was investigated. Delta9-THC dose-dependently increased HP (0.05-1 mg kg-1, s.c...
  19. pmc The orexin-1 antagonist SB-334867 blocks antipsychotic treatment emergent catalepsy: implications for the treatment of extrapyramidal symptoms
    Kurt Rasmussen
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Schizophr Bull 33:1291-7. 2007
    ..Pretreatment with SB-334867 (0.01-10 mg/kg, intraperitoneal [IP]) significantly decreased the catalepsy produced by the administration of haloperidol (1 mg/kg, subcutaneous [SC]), risperidone (2 mg/kg, SC), and ..
  20. ncbi Intracerebroventricular administration of nitric oxide-sensitive guanylyl cyclase inhibitors induces catalepsy in mice
    M B Echeverry
    Department MEF Physiology, FORP, University of Sao Paulo, Av Café S No, 14040 904, Ribeirao Preto, SP, Brazil
    Psychopharmacology (Berl) 194:271-8. 2007
    b>Catalepsy is a preclinical test that predicts extrapyramidal symptoms in humans. It models symptoms of acute extrapyramidal side effects induced at the beginning of antipsychotic treatment...
  21. ncbi Catalepsy induced by intra-striatal administration of nitric oxide synthase inhibitors in rats
    Elaine A Del Bel
    Department MEF Physiology, School of Odontology, FORP, Campus USP, Av Café S N, Ribeirao Preto, SP 14040 904, Brazil
    Eur J Pharmacol 485:175-81. 2004
    Systemic administration of nitric oxide synthase (NOS) inhibitors induces catalepsy in a dose-dependent manner in male Albino-Swiss mice...
  22. ncbi Coadministration of L-NOARG and tiapride: effects on catalepsy in male mice
    Maria Cavas
    Department of Psychobiology, School of Psychology, , Spain
    Prog Neuropsychopharmacol Biol Psychiatry 26:69-73. 2002
    This study was designed to determine the possible potentiation of catalepsy behavior after coadministration of N(G)-nitro-L-arginine (L-NOARG), an inhibitor of nitric oxide synthase (NOS), and tiapride, a specific antagonist for D2 ..
  23. ncbi Acute effects of selective serotonin reuptake inhibitors on neuroleptic-induced catalepsy in mice
    J G P Pires
    Departamento de Ciencias Fisiologicas, Centro Biomedico, Universidade Federal do Espirito Santo, Av Marechal Campus 1468, 29040 090 Vitória, ES, Brazil
    Braz J Med Biol Res 38:1867-72. 2005
    ..Drugs that modify experimental neuroleptic catalepsy (NC) might affect extrapyramidal symptoms in PD...
  24. pmc Evaluation of age and sex differences in locomotion and catalepsy during repeated administration of haloperidol and clozapine in adolescent and adult rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298 0613, USA
    Pharmacol Res 58:240-6. 2008
    ..Rats were injected daily with saline, 0.3 mg/kg haloperidol, or 10 mg/kg clozapine for 10 days and activity and catalepsy were measured...
  25. ncbi Mirtazapine enhances the effect of haloperidol on apomorphine-induced climbing behaviour in mice and attenuates haloperidol-induced catalepsy in rats
    H H Berendsen
    Department of Neuropharmacology, N V Organon, Oss, The Netherlands
    Psychopharmacology (Berl) 135:284-9. 1998
    Activation of 5-HT1A receptors has been shown to attenuate catalepsy induced by typical antipsychotic compounds...
  26. ncbi Sub-chronic inhibition of nitric-oxide synthesis modifies haloperidol-induced catalepsy and the number of NADPH-diaphorase neurons in mice
    E A Del Bel
    Department of Physiology, School of Odontology, FORP, Ribeirao Preto, SP, Brazil
    Psychopharmacology (Berl) 147:356-61. 2000
    NG-nitro-L-arginine (L-NOARG), an inhibitor of nitric-oxide synthase (NOS), induces catalepsy in mice. This effect undergoes rapid tolerance, showing a significant decrease after 2 days of sub-chronic L-NOARG treatment...
  27. ncbi Catalepsy induced by a blockade of dopamine D1 or D2 receptors was reversed by a concomitant blockade of adenosine A(2A) receptors in the caudate-putamen of rats
    W Hauber
    Department of Animal Physiology, Institute of Biology, University of Stuttgart, D 70550 Stuttgart, Germany
    Eur J Neurosci 14:1287-93. 2001
    ..to determine, in more detail, the effects of an unselective and a selective adenosine A(2A) receptor blockade on catalepsy induced by a blockade of dopamine D1 or D2 receptors in rats...
  28. pmc Loss of haloperidol induced gene expression and catalepsy in protein kinase A-deficient mice
    M R Adams
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 94:12157-61. 1997
    ..These results establish a direct role for protein kinase A as a mediator of haloperidol induced gene induction and cataleptic behavior...
  29. ncbi Detection and mapping of quantitative trait loci for haloperidol-induced catalepsy in a C57BL/6J x DBA/2J F2 intercross
    N V Patel
    Department of Psychiatry, SUNY 11794 8101, USA
    Behav Genet 29:303-10. 1999
    A genomewide scan was conducted to detect quantitative trait loci (QTLs) for haloperidol-induced catalepsy in a C57BL/6J (B6) x DBA/2J (D2) F2 intercross (N = 678). Significant QTLs (LOD, > 4.3) were detected on chromosomes 1 and 9...
  30. ncbi Delta 9-tetrahydrocannabinol-induced catalepsy-like immobilization is mediated by decreased 5-HT neurotransmission in the nucleus accumbens due to the action of glutamate-containing neurons
    K Sano
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma 8 19 1, Fukuoka City, Fukuoka 814 0180, Japan
    Neuroscience 151:320-8. 2008
    Delta(9)-tetrahydrocannabinol (THC) has been reported to induce catalepsy-like immobilization, but the mechanism underlying this effect remains unclear...
  31. ncbi Characterization of the quantitative trait locus for haloperidol-induced catalepsy on distal mouse chromosome 1
    J R Hofstetter
    Department of Veterans Affairs, Richard L Roudebush Medical Center, Indianapolis, IN 46202, USA
    Genes Brain Behav 7:214-23. 2008
    We report here the confirmation of the quantitative trait locus for haloperidol-induced catalepsy on distal chromosome (Chr) 1. We determined that this quantitative trait locus was captured in the B6...
  32. ncbi Differential effects of cyclooxygenase inhibitors on haloperidol-induced catalepsy
    Pattipati S Naidu
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Prog Neuropsychopharmacol Biol Psychiatry 26:819-22. 2002
    ..cyclooxygenase (COX) inhibitor, dose-dependently (5 and 10 mg/kg) antagonized the haloperidol-induced catalepsy in mice...
  33. ncbi Diurnal variations in lymphocyte subpopulations in lymphoid organs of rats with genetic catalepsy and Wistar rats
    N G Panteleeva
    Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk
    Bull Exp Biol Med 137:288-90. 2004
    Parameters of the immune status of the thymus and spleen in rats with genetic catalepsy were lower compared to those in Wistar rats. Diurnal variations in cell subpopulations of lymphoid organs were different in animals of these strains...
  34. ncbi Gender-related differences in the effects of nitric oxide donors on neuroleptic-induced catalepsy in mice
    J G P Pires
    Departamento de Ciencias Fisiologicas, Centro Biomedico, Universidade Federal do Espirito Santo, Vitoria, ES, Brasil
    Braz J Med Biol Res 36:239-45. 2003
    ..and S-nitroso-N-acetylpenicillamine (SNAP), three pharmacologically different NO donors, on neuroleptic-induced catalepsy in 60- to 80-day-old male and female albino mice...
  35. ncbi Synthesis of some urea and thiourea derivatives of 3-phenyl/ethyl-2-thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidine and their antagonistic effects on haloperidol-induced catalepsy and oxidative stress in mice
    Faizul Azam
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Seventh October, Misurata, Libya
    Eur J Med Chem 44:3889-97. 2009
    ..All the compounds have been evaluated for their antiparkinsonian activity in catalepsy induced by haloperidol in mice...
  36. ncbi Design, synthesis and anti-Parkinsonian evaluation of 3-alkyl/aryl-8-(furan-2-yl)thiazolo[5,4-e][1,2,4]triazolo[1,5-c]pyrimidine-2(3H)-thiones against neuroleptic-induced catalepsy and oxidative stress in mice
    Faizul Azam
    Laboratory of Medicinal Chemistry, Faculty of Pharmacy, University of Seventh October, Misurata, Libya
    J Enzyme Inhib Med Chem 25:818-26. 2010
    ..All of the compounds were found to be active in haloperidol-induced catalepsy and oxidative stress in mice...
  37. ncbi Buspirone improves 6-hydroxydopamine-induced catalepsy through stimulation of nigral 5-HT(1A) receptors in rats
    Alireza M Nayebi
    Drug Applied Research Center, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran
    Pharmacol Rep 62:258-64. 2010
    ..the effect of buspirone, as a partial agonist of 5-HT(1A) receptors, on 6-hydroxydopamine (6-OHDA)-induced catalepsy in male Wistar rats...
  38. ncbi Role of adenosine and N-methyl-D-aspartate receptors in mediating haloperidol-induced gene expression and catalepsy
    E H Chartoff
    Program in Neurobiology and Behavior, University of Washington, Seattle, Washington, USA
    J Pharmacol Exp Ther 291:531-7. 1999
    ..An acute behavioral response to haloperidol is catalepsy, considered to be a rodent correlate of some of the immediate extrapyramidal motor side effects seen in humans...
  39. ncbi Effect of BR-16A (Mentat), a polyherbal formulation on drug-induced catalepsy in mice
    Anil Kumar
    University Institute of Pharmaceutical Science, Panjab University, Chandigarh 160 014, India
    Indian J Exp Biol 44:45-8. 2006
    ..Neuroleptic-induced catalepsy has long been used as an animal model for screening drugs for Parkinsonism...
  40. ncbi Adenosine A2A receptor knockout mice are partially protected against drug-induced catalepsy
    M El Yacoubi
    UMR 6036 CNRS, IFRMP 23, , Rouen, France
    Neuroreport 12:983-6. 2001
    b>Catalepsy assessed using the bar test was measured in both adenosine A2A receptor knockout (A2AR KO) and wild-type (A2AR WT) mice submitted to acute administration of the dopamine D2 receptor antagonist haloperidol (0.5, 2, 4, 6 mg/kg i...
  41. ncbi Involvement of 5-hydroxytryptamine1A receptors in Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka, University, 8 19 1, Nanakuma, Fukuoka 814 0180, Japan
    Eur J Pharmacol 550:117-22. 2006
    ..the involvement of 5-hydroxytryptamine(1A) (5-HT(1A)) receptors in Delta(9)-tetrahydrocannabinol (THC)-induced catalepsy-like immobilization in mice. THC (10 mg/kg, i.p...
  42. ncbi Delta9-tetrahydrocannbinol accounts for the antinociceptive, hypothermic, and cataleptic effects of marijuana in mice
    S A Varvel
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 314:329-37. 2005
    ..First, the effects of delta9-THC on analgesia, hypothermia, and catalepsy were compared with those of a marijuana extract with equated delta9-THC content after either i.v...
  43. ncbi Ecstasy counteracts catalepsy in rats, an anti-parkinsonian effect?
    Werner J Schmidt
    Zoological Institute, Neuropharmacology, Mohlstrasse 54 1, University Tübingen, 72074 Tubingen, Germany
    Neurosci Lett 330:251-4. 2002
    ..From the supraadditive effect of the enantiomers it may be concluded that both enantiomers contribute to the antiparkinsonian effects at two different target sites...
  44. ncbi Evaluation of amphetamine-induced hyperlocomotion and catalepsy following long-acting risperidone administration in rats
    Giorgio Marchese
    CNR, Institute of Biomedical Technology, Sect Cagliari, Technological Park of Sardinia Sardegna Ricerche, Pula, Cagliari, Italy
    Eur J Pharmacol 620:36-41. 2009
    ..To ascertain this hypothesis, antagonism of amphetamine-induced hyperlocomotion and catalepsy were analyzed in rats for a period of 1-6 weeks following long-acting risperidone (20-60 mg/kg) injection...
  45. ncbi Dopamine D2 receptor occupancy predicts catalepsy and the suppression of conditioned avoidance response behavior in rats
    M L Wadenberg
    Section of Biopsychology, CAMH, University of Toronto, Canada
    Psychopharmacology (Berl) 150:422-9. 2000
    ..Patients showed a clinical response with > or = 65% D2 occupancy, but EPS only when D2 occupancy >78%. Catalepsy and the selective suppression of conditioned avoidance response (CAR) are often used as animal models to predict ..
  46. ncbi Effect of NR-ANX-C (a polyherbal formulation) on haloperidol induced catalepsy in albino mice
    Vinod Nair
    Department of Pharmacology, Kasturba Medical College, Mangalore, India
    Indian J Med Res 126:480-4. 2007
    ..In rodents, administration of haloperidol leads to the development of a behavioural state called catalepsy, in which the animal is not able to correct an externally imposed posture...
  47. ncbi Enhanced efficacy of both typical and atypical antipsychotic drugs by adjunctive alpha2 adrenoceptor blockade: experimental evidence
    Marie Louise Wadenberg
    Department of Physiology and Pharmacology, Section of Neuropsychopharmacology, Karolinska Institutet, Stockholm, Sweden
    Int J Neuropsychopharmacol 10:191-202. 2007
    ..olanzapine) antipsychotic drug, both lacking appreciable alpha2 adrenoceptor affinity, on (i) CAR; (ii) catalepsy; and (iii) DA output in the prefrontal cortex and the nucleus accumbens using microdialysis...
  48. ncbi In vitro and in vivo characterization of F-97013-GD, a partial 5-HT1A agonist with antipsychotic- and antiparkinsonian-like properties
    Arturo Zazpe
    Department of Research, FAES FARMA, S A, Máximo Aguirre 14, 48940 Leioa, Vizcaya, Spain
    Neuropharmacology 51:129-40. 2006
    ..In addition, only high doses of F-97013-GD induced catalepsy in rodents and, like 8-OH-DPAT and clozapine, the compound reversed the haloperidol-induced catalepsy in rats...
  49. ncbi Effects of Ipomoea carnea aqueous fraction intake by dams during pregnancy on the physical and neurobehavioral development of rat offspring
    A Schwarz
    Department of Pathology, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Av Prof Dr Orlando Marques de Paiva, 87, CEP 05508 900, Sao Paulo, Sao Paulo, Brazil
    Neurotoxicol Teratol 25:615-26. 2003
    ..The physical and reflex developmental parameters, open-field, plus-maze, social interaction, forced swimming, catalepsy and stereotyped behaviors, as well as striatal, cortical and hypothalamic monoamine levels (at 140 days of age) ..
  50. ncbi Some behavioural effects of carbamazepine - comparison with haloperidol
    E Nowakowska
    Department of Pharmacoeconomics and Social Pharmacy, Karol Marcinkowski University of Medical Sciences, Poznan, Poland
    J Physiol Pharmacol 58:253-64. 2007
    ..CBZ did not induce catalepsy after single as well as chronic administration...
  51. ncbi Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models
    Sridhar Natesan
    Schizophrenia Program and the PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 31:1854-63. 2006
    ..Haloperidol and risperidone induced catalepsy at doses producing >80% D2RO, while aripiprazole despite higher D2RO (>90%) induced no catalepsy...
  52. ncbi Catalepsy intensifies context-dependently irrespective of whether it is induced by intermittent or chronic dopamine deficiency
    A Klein
    Zoological Institute, Neuropharmacology, University of Tuebingen, Germany
    Behav Pharmacol 14:49-53. 2003
    It is well known that neuroleptic-induced catalepsy in rats intensifies upon repeated testing...
  53. ncbi Pharmacological actions of a novel and selective dopamine D3 receptor antagonist, KCH-1110
    Woo Kyu Park
    Pharmaceutical Screening Research Team, Korea Research Institute of Chemical Technology, 100 Jang Dong, Yusong gu, Daejon 305 343, South Korea
    Pharmacol Res 48:615-22. 2003
    ..KCH-1110 did not induce catalepsy in mice, but at much higher doses only a slight catalepsy response was shown...
  54. ncbi A role for presynaptic mechanisms in the actions of nomifensine and haloperidol
    P A Garris
    Cellular and Integrative Physiology Section, Department of Biological Sciences, Illinois State University, Normal, IL 61790 4120, USA
    Neuroscience 118:819-29. 2003
    ..effects on dopaminergic signaling and produce the dopamine (DA)-related behaviors of motor activation and catalepsy, respectively...
  55. ncbi Effects of tryptophan and valine administration on behavioral pharmacology of haloperidol
    Obaid Ali
    Central Drugs Laboratory, Ministry of Health, Government of Pakistan, Pakistan
    Pak J Pharm Sci 18:23-8. 2005
    ..and a large neutral amino acid other than tryptophan (valine) on the modulation of haloperidol induced catalepsy and akinesia...
  56. ncbi Aripiprazole, an atypical antipsychotic, prevents the motor hyperactivity induced by psychotomimetics and psychostimulants in mice
    Juliana V Leite
    Department of Pharmacology, Ribeirao Preto School of Medicine, University of São Paulo Av Bandeirantes 3900, Ribeirao Preto SP, 14049 900, Brazil
    Eur J Pharmacol 578:222-7. 2008
    ..Independent groups also received aripiprazole (0.1-1 mg/kg) or haloperidol (0.5 mg/kg) and were tested for catalepsy. All doses of aripiprazole were effective in preventing the motor stimulant effects of amphetamine and cocaine...
  57. ncbi Effects of group I metabotropic glutamate receptors blockade in experimental models of Parkinson's disease
    Andrzej Dekundy
    Preclinical R and D, Merz Pharmaceuticals GmbH, Eckenheimer Landstr 100, 60318 Frankfurt am Main, Germany
    Brain Res Bull 69:318-26. 2006
    ..EMQMCM), in animal studies indicative of antiparkinsonian-like activity such as haloperidol-induced catalepsy, hypoactivity in open field following haloperidol, and rotation in rats with unilateral 6-hydroxydopamine(OHDA)-..
  58. ncbi ACP-103, a 5-hydroxytryptamine 2A receptor inverse agonist, improves the antipsychotic efficacy and side-effect profile of haloperidol and risperidone in experimental models
    Luis R Gardell
    ACADIA Pharmaceuticals, Inc, 3911 Sorrento Valley Blvd, San Diego, CA 92121, USA
    J Pharmacol Exp Ther 322:862-70. 2007
    ..ACP-103 also attenuated catalepsy produced by haloperidol or risperidone...
  59. ncbi Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis
    Judith A Siuciak
    CNS Discovery, MS 8220 4142, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
    Neuropharmacology 51:386-96. 2006
    ..In rats, papaverine potentiates haloperidol-induced catalepsy, consistent with the hypothesis that inhibition of PDE10A can increase striatal output and prompting a further ..
  60. ncbi Pharmacological profiles in rats of novel antipsychotics with combined dopamine D2/serotonin 5-HT1A activity: comparison with typical and atypical conventional antipsychotics
    Laurent Bardin
    Division of Neurobiology, Pierre Fabre Research Centre, Castres, France
    Behav Pharmacol 18:103-18. 2007
    ..Propensity to induce catalepsy, predictive of occurrence of extrapyramidal side effects, was inversely related to affinity at 5-HT1A receptors...
  61. ncbi Contrasting loxapine to its isomer isoloxapine--the critical role of in vivo D2 blockade in determining atypicality
    Sridhar Natesan
    Schizophrenia PET program, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada, M5T 1R8
    Schizophr Res 77:189-99. 2005
    ..The purpose of this study was to systematically compare the two drugs in in vitro and in vivo animal models, and to understand mechanisms underlying their differential typical/atypical profiles...
  62. ncbi Aripiprazole and its human metabolite are partial agonists at the human dopamine D2 receptor, but the rodent metabolite displays antagonist properties
    Martyn D Wood
    Psychiatry Centre for Excellence in Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
    Eur J Pharmacol 546:88-94. 2006
    ....
  63. ncbi Reversal of haloperidol-induced extrapyramidal symptoms by buspirone: a time-related study
    Darakhshan Jabeen Haleem
    Department of Biochemistry, Neurochemistry and Biochemical Neuropharmacology Research Laboratory, University of Karachi, Karachi, Pakistan
    Behav Pharmacol 18:147-53. 2007
    ..Prior administration of buspirone for 2 weeks may be of help in the improvement of extrapyramidal symptoms induced by antipsychotic drugs...
  64. ncbi Anticataleptic properties of alpha2 adrenergic antagonists in the crossed leg position and bar tests: differential mediation by 5-HT1A receptor activation
    Mark S Kleven
    Neurobiology II, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F 81106 Castres, France
    Psychopharmacology (Berl) 177:373-80. 2005
    ..improve the antipsychotic-like effects of neuroleptics and attenuate dopamine D(2) receptor antagonist-induced catalepsy. However, several alpha(2) adrenergic antagonists also display serotonin 5-HT(1A) receptor agonist activity, ..
  65. ncbi Streptozotocin-induced diabetes differentially modifies haloperidol- and gamma-hydroxybutyric acid (GHB)-induced catalepsy
    Rajkumar J Sevak
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Eur J Pharmacol 517:64-7. 2005
    ..Haloperidol and GHB produced catalepsy in control and diabetic rats; haloperidol was less potent in diabetic rats (D(50)=0...
  66. ncbi Decreased brain docosahexaenoic acid during development alters dopamine-related behaviors in adult rats that are differentially affected by dietary remediation
    Beth Levant
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Mail Stop 1018, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Behav Brain Res 152:49-57. 2004
    ..Beginning at P56, rats were subjected to a battery of behavioral tests. Catalepsy induced by haloperidol (3mg/kg, i.p.) in deficient animals was 49% of that observed in control animals (P < 0...
  67. ncbi Haloperidol versus risperidone on rat "early onset" vacuous chewing
    Giorgio Marchese
    Neuroscienze S c ar l, Via Palabanda 9, 09123, Cagliari, Italy
    Behav Brain Res 149:9-16. 2004
    Similarly to acute rat catalepsy, "early onset" vacuous chewing movements (VCMs) induced by subchronic treatment with antipsychotic have recently been proposed as a model of human extrapyramidal symptoms...
  68. pmc Neuroleptic-like effects of gamma-hydroxybutyrate: interactions with haloperidol and dizocilpine
    Rajkumar J Sevak
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Eur J Pharmacol 483:289-93. 2004
    ..Here, we examined the ability of GHB and haloperidol to induce catalepsy and to affect operant responding. When given alone, both compounds induced catalepsy and decreased response rate...
  69. ncbi Novel antipsychotic agents with 5-HT(1A) agonist properties: role of 5-HT(1A) receptor activation in attenuation of catalepsy induction in rats
    Mark S Kleven
    Pierre Fabre Research Centre, Neurobiology 2 Division, 17 Ave Jean Moulin, 81106 Castres, France
    Neuropharmacology 49:135-43. 2005
    Compounds possessing 5-HT(1A) agonist properties attenuate catalepsy induced by D(2) receptor blockade...
  70. ncbi Impairment of dopaminergic system function after chronic treatment with corticotropin-releasing factor
    Emanuela Izzo
    Department of Neuropharmacology, CVN 12, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, California, CA 92037, USA
    Pharmacol Biochem Behav 81:701-8. 2005
    ....
  71. ncbi Intensification of cataleptic response in 6-hydroxydopamine-induced neurodegeneration of substantia nigra is not dependent on the degree of dopamine depletion
    J Srinivasan
    Zoological Institute, Neuropharmacology, University of Tuebingen, Tuebingen 72076, Germany
    Synapse 51:213-8. 2004
    An intensification of catalepsy has been observed upon repeated testing in rats with permanent neurodegeneration of substantia nigra...
  72. ncbi Brain tyrosine depletion attenuates haloperidol-induced striatal dopamine release in vivo and augments haloperidol-induced catalepsy in the rat
    George E Jaskiw
    Psychiatry Service 116A B, Louis Stokes Cleveland VAMC, 10000 Brecksville Road, Brecksville, OH 44141, USA
    Psychopharmacology (Berl) 172:100-7. 2004
    ..Since the DA antagonist haloperidol (HAL) increases striatal DA release and induces catalepsy through its actions on striatal DA systems, it provides a useful paradigm to assess both neurochemical and ..
  73. ncbi Design and synthesis of trans-3-(2-(4-((3-(3-(5-methyl-1,2,4-oxadiazolyl))- phenyl)carboxamido)cyclohexyl)ethyl)-7-methylsulfonyl-2,3,4,5-tetrahydro-1H-3-benzazepine (SB-414796): a potent and selective dopamine D3 receptor antagonist
    Gregor J Macdonald
    GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, UK
    J Med Chem 46:4952-64. 2003
    ....
  74. ncbi Design, synthesis, and evaluation of the antipsychotic potential of orally bioavailable neurotensin (8-13) analogues containing non-natural arginine and lysine residues
    M Kyle Hadden
    Department of Pharmaceutical Sciences, Medical University of South Carolina, 280 Calhoun Street, PO Box 250140, Charleston, SC 29425, USA
    Neuropharmacology 49:1149-59. 2005
    ..Finally, KH28 did not produce catalepsy, a deleterious side-effect elicited by classical antipsychotic drugs...
  75. ncbi The acute EPS of haloperidol may be unrelated to its metabolic transformation to BCPP+
    Donald M N Sikazwe
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, FL 32307, USA
    Bioorg Med Chem Lett 13:3779-82. 2003
    ..This study suggests that D2 affinity may be the primary underlying mechanism for acute catalepsy induction by haloperidol.
  76. ncbi Evaluation of N-desmethylclozapine as a potential antipsychotic--preclinical studies
    Sridhar Natesan
    1Schizophrenia Program and the PET Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Neuropsychopharmacology 32:1540-9. 2007
    ..hyperlocomotion (AIL) and conditioned avoidance response (CAR) models); measures predictive of side effects (catalepsy and prolactin elevation); and molecular markers predictive of antipsychotic action (striatal Fos induction)...
  77. ncbi CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity
    Judith A Siuciak
    CNS Discovery, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
    Neuropharmacology 52:279-90. 2007
    ..At doses up to 56 mg/kg, CP-809,101 did not produce catalepsy. Thus, the present results demonstrate that the 5-HT(2C) agonist, CP-809,101, has a pharmacological profile ..
  78. ncbi Increasing D2 affinity results in the loss of clozapine's atypical antipsychotic action
    Shitij Kapur
    Department of Psychiatry, University of Toronto, Toronto M5S 3H6, Canada
    Neuroreport 13:831-5. 2002
    ..When tested in a series of animal models indicative of the typical/atypical distinction (catalepsy, striatal gene-induction, prolactin elevation) isoclozapine lost atypical properties and behaved like a typical ..
  79. ncbi The neurosteroid 3 alpha-hydroxy-5 alpha-pregnan-20-one affects dopamine-mediated behavior in rodents
    Rahul T Khisti
    Department of Pharmaceutical Sciences, Nagpur University Campus, Nagpur 440 010, Maharashtra, India
    Psychopharmacology (Berl) 161:120-8. 2002
    The neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-THP) has been previously shown to induce catalepsy in mice that is modified by GABAergic, dopaminergic, adenosinergic and serotonergic agents...
  80. ncbi Central 5-HT(4) receptors and dopamine-dependent motor behaviors: searching for a functional role
    Philippe De Deurwaerdère
    Laboratoire Neuropsychobiologie des Desadaptations, UMR CNRS 5541, Universite Victor Segalen Bordeaux 2, B P 31, 146 rue Leo Saignat, 33077 Cedex, Bordeaux, France
    Pharmacol Biochem Behav 71:627-33. 2002
    ..motor behaviors related to change of nigrostriatal dopamine (DA) transmission, namely, stereotyped behavior and catalepsy in rats...
  81. pmc Neuroleptics and animal models: feasibility of oral treatment monitored by plasma levels and receptor occupancy assays
    Emma Perez-Costas
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, SPARKS Center SC865, Birmingham, AL 35294, USA
    J Neural Transm 115:745-53. 2008
    ....
  82. ncbi Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies
    Giuseppe Campiani
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via Aldo Moro, 53100 Siena, Italy
    J Med Chem 45:344-59. 2002
    ..This atypical antipsychotic lead has low propensity to induce catalepsy in rat...
  83. ncbi Dysregulation of the mesolimbic dopamine system and reward in MCH-/- mice
    Pavlos Pissios
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Biol Psychiatry 64:184-91. 2008
    ....
  84. ncbi Possible involvement of prostaglandins in haloperidol-induced orofacial dyskinesia in rats
    P S Naidu
    Division of Pharmacology, University Institute of Pharmaceutical Sciences, Panjab University, 160014, Chandigarh, India
    Eur J Pharmacol 430:295-8. 2001
    ..Behavioural assessment of orofacial dyskinesia was done 24 h after the last dose of haloperidol. Catalepsy was induced in rats by acute treatment with haloperidol (1 mg/kg), and catalepsy was scored for the next 4 h...
  85. ncbi Mechanisms for metoclopramide-mediated sensitization and haloperidol-induced catalepsy in rats
    Mervan S Agovic
    Department of Physiology and Pharmacology, The City University of New York, Medical School, New York, New York 10031, USA
    Eur J Pharmacol 587:181-6. 2008
    ..such as the dopamine D(2) receptor antagonist, haloperidol are known to cause movement disorders or catalepsy in experimental animals. Catalepsy is believed to result from blockade of dopamine D(2) receptors...
  86. ncbi Dosing time-dependent tolerance of catalepsy by repetitive administration of haloperidol in mice
    J Viyoch
    Department of Clinical Pharmacokinetics, Division of Pharmaceutical Sciences, Graduate School, Kyushu University, Higashi-ku, Fukuoka, Japan
    J Pharmacol Exp Ther 298:964-9. 2001
    ..p. at 9:00 AM or 9:00 PM, the time nearly corresponding to the maximal or minimal catalepsy responses to a single dose, respectively, for 14 days and catalepsy responses were monitored at 1 h after ..
  87. ncbi Effects of buspirone on dopamine dependent behaviours in rats
    A G Dhavalshankh
    Department of Pharmacology, Krishna Institute of Medical Sciences, Karad
    Indian J Physiol Pharmacol 51:375-86. 2007
    ..apomorphine in biochemical presynaptic nigrostriatal D2 DA autoreceptor test systems buspirone neither induced catalepsy nor antagonised apomorphine-induced turning behaviour in rats indicating that at these doses buspirone does not ..
  88. pmc Feeding conditions differentially affect the neurochemical and behavioral effects of dopaminergic drugs in male rats
    Rajkumar J Sevak
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, United States
    Eur J Pharmacol 592:109-15. 2008
    ..the dopamine receptor agonist quinpirole (yawning), and the dopamine receptor antagonist raclopride (catalepsy). Amphetamine increased locomotion and produced conditioned place preference...
  89. ncbi Behavioral and biochemical effects of amperozide and serotonin agents on nigrostriatal and mesolimbic dopamine systems
    Pu Yuan Chang
    Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Chin J Physiol 51:106-15. 2008
    ..Furthermore, DOI and amperozide, but not ritanserin, reduced the haloperidol-induced catalepsy. [corrected] When animals were unilaterally radiofrequency lesioned in either caudate putamen (CP) or nucleus ..
  90. ncbi Dopamine D2 long receptor-deficient mice display alterations in striatum-dependent functions
    Y Wang
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
    J Neurosci 20:8305-14. 2000
    ..Interestingly, haloperidol produced significantly less catalepsy and inhibition of locomotor activity in D2L-/- mice...
  91. ncbi Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6-hydroxydopamine-induced partial degeneration of substantia nigra in rats
    J Srinivasan
    Zoological Institute, Neuropharmacology, University of Tuebingen, Auf der Morgenstelle 28E, 72076, Tuebingen, Germany
    Eur J Neurosci 17:2586-92. 2003
    ..Behaviour was evaluated by catalepsy tests and activity box...
  92. ncbi [Neuroleptic-like activity of the tripeptide neurotensin analog GZR-123]
    L S Guzevatykh
    Laboratory of Psychopharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul 8, Moscow, 125315 Russia
    Eksp Klin Farmakol 65:3-6. 2002
    ..At a dose 1250 times the ED50 for apomorphine and L-DOPA dependent tests, GZR-123 did not cause acute toxicity and did not provoke catalepsy.
  93. ncbi Nootropic activity of Albizzia lebbeck in mice
    S D Chintawar
    Department of Pharmacology, M V P Samaj s College of Pharmacy, Nashik 422 002, Maharashtra, India
    J Ethnopharmacol 81:299-305. 2002
    ..The brain concentrations of GABA and dopamine were decreased, whereas the 5-HT level was increased. The data indicate the involvement of monoamine neurotransmitters in the nootropic action of BF of A. lebbeck...
  94. ncbi Effects of dopamine receptor blockade on cerebral blood flow response to somatosensory stimulation in the unanesthetized rat
    Takanori Esaki
    Laboratory of Cerebral Metabolism, National Institute of Mental Health NIH, Building 36, 36 Convent Drive, Bethesda, MD 20892 4030, USA
    J Pharmacol Exp Ther 303:497-502. 2002
    ..These results do not support a role for direct dopaminergic vasoactive mechanisms in the increases in CBF associated with neuronal functional activation...
  95. ncbi Dopamine D3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in rats
    Stanislav R Vorel
    Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Neurosci 22:9595-603. 2002
    ....
  96. ncbi Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 2: asymmetric synthesis and biological evaluation
    He Zhao
    Neurogen Corporation, 35Northeast Industrial Road, Branford, CT 06405, USA
    Bioorg Med Chem Lett 12:3111-5. 2002
    ..Three compounds having D(2)/D(4) affinity ratios approximating that found for the atypical neuroleptic clozapine were further evaluated in behavioral tests of antipsychotic efficacy and motor side effects...
  97. ncbi In vitro and in vivo pharmacological profile of 4-(4-fluorobenzylidene)-1-[2-[5-(4-fluorophenyl)-1H-pyrazol-4-yl] ethyl] piperidine (NRA0161)
    Yoshiko Suzuki
    Molecular Biology Laboratory, Taisho Pharmaceutical Co, Ltd, 1 403 Yoshino cho, Saitama shi, Saitama, 330 8530, Japan
    Life Sci 71:2603-15. 2002
    ..antagonized the MAP-induced stereotyped behavior in mice and NRA0161 dose-dependently and significantly induced catalepsy in rats...
  98. ncbi Effects of dextromethorphan on dopamine dependent behaviours in rats
    R V Gaikwad
    Department of Pharmacology, Krishna Institute of Medical Sciences, Karad 415 110, India
    Indian J Exp Biol 45:712-9. 2007
    ..5-75 mg/kg, ip did not induce oral stereotypies or catalepsy and did not antagonize apomorphine stereotypy in rats. These results indicate that dextromethorphan at 7...
  99. ncbi Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, potentiates neurochemical and behavioral effects of haloperidol in the rat
    Catherine Pillot
    Laboratoire de Physiologie, Faculte des Sciences Pharmaceutiques et Biologiques, 75006 Paris, France
    J Neurosci 22:7272-80. 2002
    ..any motor effect when used alone, ciproxifan strongly potentiated haloperidol-induced locomotor hypoactivity and catalepsy, two behaviors in which striatal neurons are involved...
  100. ncbi The differential effect of haloperidol and repetitive induction on four immobility responses in mouse and guinea pig
    T Fregoso-Aguilar
    Department of Physiology, National School of Biological Sciences, National Polytechnic Institute, Mexico
    Behav Pharmacol 13:253-60. 2002
    ....
  101. ncbi Cyclooxygenase inhibitor modulation of dopamine-related behaviours
    Brian M Ross
    Highland Psychiatric Research Foundation, UHI Millennium Institute, The Greenhouse, Beechwood Business Park North, Inverness, Scotland IV2 3ED, UK
    Eur J Pharmacol 450:141-51. 2002
    ..Both drugs inhibited catalepsy induced by the dopamine D1-like receptor antagonist R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-..

Research Grants60

  1. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
    ..two QTLs found on chromosomes 1 and 14 and which have been repeatedly shown to be associated with the catalepsy response...
  2. CB1 Receptor Regulation by Cannabinoid Receptor Interacting Protein CRIP1a
    DANA E contact SELLEY; Fiscal Year: 2010
    ..effects of the knockout on the pharmacological potency of CB agonists in tests of hypothermia, hypolocomotion, catalepsy and antinociception...
  3. Dorsal Column Stimulation as a New Therapy for Motor Disorders
    Miguel A L Nicolelis; Fiscal Year: 2013
    ..Open field activity, catalepsy tests and rotating rod tests will be used to evaluate their motor function and compare it to a sham treated ..
  4. CB1 and DA Receptor Deletion by RNAi in Cocaine Self-Administration
    CAROLINE EVELYN BASS; Fiscal Year: 2011
    ..and medulla and assessing the efficacy of THC in inducing antinociception, hypoactivity, hypothermia, and catalepsy;3) delineate and define the contribution of D1 and D2 receptors in the ventral striatum, dorsal striatum and VTA ..
  5. Design of New Therapeutic Agents to Treat Schizophrenia
    James M Cook; Fiscal Year: 2013
    ..to reverse the cognitive symptoms of schizophrenia in the PPI model of PCP treated rats but induced no signs of catalepsy. Under specific aims 2 and 3, synthetic routes to generate the proposed compounds are already establish and ..
  6. Candidate Medications for Cannabis Addiction: FAAH Inhibitors
    Alexandros Makriyannis; Fiscal Year: 2013
    ..receptor binding, plasma and microsomal stability) and in vivo endpoints (brain penetrability, hypothermia, catalepsy, and drug discrimination) to identify novel FAAH inhibitors as 'lead'compounds...
  7. Novel Neurotensin Analogs as Antischizophrenics
    Thomas A Dix; Fiscal Year: 2012
    ..This compound showed strong efficacy in the key rat models of psychosis, did not cause catalepsy, and animals did not develop resistance to it...
  8. Evaluating BMY-14802 as an anti-dyskinesia treatment in the 6-OHDA rat model of P
    MELANIE PAQUETTE; Fiscal Year: 2009
    ..Antagonism of the D2 receptor is observed behaviorally as catalepsy, a slowness to move out of awkward positions...
  9. CANNABINOIDS AND THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
    Laura Murphy; Fiscal Year: 2002
    ..Furthermore, the role of CRH in the ability of cannabinoids to decrease luteinizing hormone (LH) and induce catalepsy and alterations in feeding behavior will be investigated...
  10. DRUG SELF ADMINISTRATION IN MOUSE MODELS OF NEUROAIDS
    Lisa Gold; Fiscal Year: 1999
    ..drug probes in tasks assessing learning (nonconditional spatial discrimination), motor activity (locomotion, catalepsy), and analgesia...
  11. EFFECTS OF ACUTE BENZODIAZEPINE GROWING WITH TIME
    SEYMOUR ANTELMAN; Fiscal Year: 1990
    ..same dose readministered two weeks later; 2) one injection of diazepam significantly sensitizes both haloperidol catalepsy and ptosis two weeks but not two hours later; 3) a single injection of saline 1 month earlier completely ..
  12. CANNABIDIOL--EFFECT ON CYTOCHROME P450 ISOZYMES
    Lester Bornheim; Fiscal Year: 2000
    ..THC) and its metabolites and metabolite half-times in the brain, but also increase the duration of THC-induced catalepsy. CBD pretreatment also increases brain levels of cocaine as well as acute cocaine-induced seizure activity and ..
  13. BIOLOGICAL ACTIVITIES OF CANNABINOIDS
    Sumner Burstein; Fiscal Year: 1993
    ..pair, will be measured and compared with tissue levels of eicosanoids and with biological endpoints such as catalepsy, analgesia and anti-edema effects...
  14. DOPAMINE AGONISTS FOR THE THERAPY OF COCAINE ADDICTION
    JOHN NEUMEYER; Fiscal Year: 1999
    ..a primate species and to further evaluate agonist efficacy in behavioral assays of eyeblinking and reversal of catalepsy induced by dopamine D1 receptor blockade, This research is expected to result in one or more dopamine D1 partial ..
  15. ELECTROPHYSIOLOGY OF CANNABINOID ACTION ON RAT BEHAVIORS
    Jing Yu Chang; Fiscal Year: 2001
    ..addition, the effect of different doses of cannabinoid on spontaneous locomotor activity (from hyper-activity to catalepsy in response to different does of cannabinoid) will be investigated...
  16. MECHANISM OF ACTION OF CANNABIS
    Sumner Burstein; Fiscal Year: 1991
    ..are proposed which will attempt to show a casual relationship between THC-induced prostaglandin changes and catalepsy and/or motor toxicity in the mouse...
  17. Developmental Psychopharmacology of Antipsychotics
    JENNY WILEY; Fiscal Year: 2007
    ..subsequently, they will be evaluated in behavioral procedures designed to measure motor activity (locomotion and catalepsy)...
  18. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2010
    ..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
  19. Discriminative Stimulus Effects of Alcohol in Mice
    Wouter Koek; Fiscal Year: 2007
    ..This future research will increase our understanding of risk factors for alcoholism and drug abuse and will help the development of effective approaches to prevention and treatment. [unreadable] [unreadable] [unreadable]..
  20. "Post-partum steroid withdrawal-induced depression"
    REBECCA CRAFT; Fiscal Year: 2006
    ..Findings from the proposed model will enhance our understanding of the etiology of PPD and possibly lead to improved treatment options. ..
  21. Brain Cannabinoid Signaling: Selectivity and Adaptation
    Laura J Sim Selley; Fiscal Year: 2010
    ..regulates acute and chronic CB1R signaling, THC-mediated in vivo effects (antinociception, locomotor inhibition, catalepsy, hypothermia) and tolerance...
  22. Drug Abuse Related Polymorphism in Fatty Acid Amide Hydrolase
    Benjamin Cravatt; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  23. Mechanisms of Amphetamine Action on Dopaminergic Signaling
    PAUL GARRIS; Fiscal Year: 2007
    ..New microsensor technology will be employed in laboratory animals to characterize amphetamine's effect on brain chemistry related to learning and motivaton. [unreadable] [unreadable] [unreadable]..
  24. NEUROPEPTIDERGIC CONTROL OF MATERNAL BEHAVIOR
    BENJAMIN NEPHEW; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  25. CB-1 Antagonists for Cannabis Addiction
    Jack Bergman; Fiscal Year: 2008
    ..neutral antagonism will be studied in rats to confirm their biological activity as antagonists of CB-1 induced catalepsy and to separate active compounds on the basis of the duration of their behavioral effects...
  26. METABOTROPIC GLUTAMATE RECEPTORS IN BASAL GANGLIA
    COLLEEN NISWENDER; Fiscal Year: 2009
    ..Furthermore, we will test the hypothesis that agonists or allosteric potentiators of this receptor can provide palliative relief in rodent models of PD by actions in the GP. ..
  27. Enzymes That Regulate Fatty Acid Amide Function In Vivo
    Benjamin Cravatt; Fiscal Year: 2009
    ..These studies will elucidate the functions of key enzymes that regulate FAA signaling in vivo. These proteins may represent new targets for the treatment of pain, addiction, and other neurological disorders. ..
  28. Pharmacotherapy of Cannabinoid Withdrawal: Pre-Clinical Studies
    Lance R McMahon; Fiscal Year: 2010
    ..Collectively, these specific aims provide a framework for developing novel pharmacotherapies of marijuana withdrawal that could markedly decrease marijuana use and dependence. ..
  29. BEHAVIORAL EFFECTS AND ABUSE OF DOPAMINERGIC DRUGS
    Jack Bergman; Fiscal Year: 2007
    ..This research should point to novel directions for the development of medications with which to manage the abuse and addictive liabilities of psychomotor stimulant drugs ..
  30. CONTROL OF ENDOCANNABINOID RELEASE IN VIVO
    Daniele Piomelli; Fiscal Year: 2003
    ..Moreover, by uncovering the neurochemical interactions between cocaine and the endogenous cannabinoids, our studies will contribute to the general understanding of substance abuse and neuropsychiatric disorders. ..
  31. Multiple Factors Affecting Placebo Response in PD
    Christopher Goetz; Fiscal Year: 2004
    ..Defining these determinant influences will help enhance placebo responses in clinical practice and control them in clinical trials. ..
  32. Feto-Maternal Pharmacokinetics of Abused Inhalants
    STEPHEN DEWEY; Fiscal Year: 2004
    ..Ultimately, the hope is to relate the mother's exposure to inhalants to the dose received by the fetus and to post-natal behavioral deficits. ..
  33. Drug discrimination and THC withdrawal in monkeys
    LANCE MCMAHON; Fiscal Year: 2005
    ..abstract_text> ..
  34. Antipsychotic-Like Drug Effects of Neurotensin
    David Feifel; Fiscal Year: 2004
    ....
  35. STRUCTURE/FUNCTION STUDIES OF FATTY ACID AMIDE HYDROLASE
    Benjamin Cravatt; Fiscal Year: 2004
    ..abstract_text> ..
  36. MOTOR EFFECTS OF ATYPICAL ANTIPSYCHOTICS
    John Salamone; Fiscal Year: 2003
    ..Taken together, the results of these experiments will help to identify the pharmacological characteristics and brain circuits that underlie the motor effects of clozapine. ..
  37. PALLIDAL GABA AND ATYPICALITY OF ANTIPSYCHOTIC DRUGS
    RONALD SEE; Fiscal Year: 2002
    ..The information obtained will facilitate the development of optimal pharmacotherapy for mental disorders, particularly schizophrenia. ..
  38. BEHAVIORAL EFFECTS OF NIGRAL D1 ANTAGONISM
    John Salamone; Fiscal Year: 2001
    ....
  39. 2006 Genes & Behavior Conference
    Robert Hitzemann; Fiscal Year: 2006
    ..We believe the second conference will be even more successful than the first. [unreadable] [unreadable] [unreadable]..
  40. Brain LC-PUFAs and Maternal Mental Health
    Beth Levant; Fiscal Year: 2006
    ..These findings will also suggest novel treatments for such illnesses when they occur. ..
  41. MOTOR ACTIONS OF CANNABINOIDS IN A PARKINSONS MODEL
    CLARA SANUDO PENA; Fiscal Year: 2002
    ..Behavioral, biochemical, and physiological studies will be conducted in parallel to test this possibility. It will also help integrate the cannabinergic system with the current knowledge of basal ganglia physiology. ..
  42. Cocaine Addiction:Medication Strategies and Evalution
    Jack Bergman; Fiscal Year: 2006
    ..abstract_text> ..
  43. Measurement of GPCR-mediated thallium flux:GIRK (RMI)
    COLLEEN NISWENDER; Fiscal Year: 2005
    ..Identified compounds will provide new pharmacological tools to test the role of the ?2C adrenergic receptor in psychiatric and cardiovascular disorders and the role of GIRK 1/2 channels in the modulation of neuronal excitability. ..
  44. DOPAMINE NEUROTRANSMISSION IN EXPERIMENTAL PARKINSONISM
    PAUL GARRIS; Fiscal Year: 2005
    ..Moreover, L-DOPA is associated with adverse side effects after extended use, apparently due to non-physiological dopamine replacement. However, how L-DOPA acts on dopaminergic signaling is not completely established. ..
  45. Translational Genetic Study of Fear and Anxiety
    ABRAHAM PALMER; Fiscal Year: 2007
    ..This training program will prepare the candidate for an academic career focused on the use of endophenotypes, animal models and bioinformatics to elucidate the genetic basis of psychiatric disease. [unreadable] [unreadable]..
  46. Characterization of a novel brain cannabinoid ligand
    Daniele Piomelli; Fiscal Year: 2010
    ..The objective of our research is to understand how these transmitters are produced and eliminated, and discover innovative medicines that target these processes. ..
  47. Cellular Mechanisms for Oligodendrocyte Myelination
    Bruce D Trapp; Fiscal Year: 2010
    ..Collectively, these studies should identify therapeutic targets that enhance remyelination and reduce the progression of neurological disability in MS patients. ..
  48. Dopamine D2 and Adenosine A2A roles:Tremulous Movements
    John Salamone; Fiscal Year: 2007
    ..abstract_text> ..
  49. Role of oleoylethanolamide in the control of food intake
    Daniele Piomelli; Fiscal Year: 2010
    ....
  50. Brain DHA, Dopamine, and Behavior: Roles in ADHD
    Beth Levant; Fiscal Year: 2006
    ..Such insights may identify a means by which certain risk factors for ADHD may be reduced or eliminated or the severity of the disease may be reduced through appropriate pre- and postnatal nutrition. [unreadable] [unreadable]..
  51. Microarray Platform for Profiling Cancer Proteases
    Benjamin Cravatt; Fiscal Year: 2008
    ..These proteases may in turn represent valuable new markers and targets for the diagnosis and treatment of cancer. ..
  52. CHEMICAL APPROACHES FOR ACTIVITY BASED PROTEOMICS
    Benjamin Cravatt; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  53. Assay for HTS of Gi/Go-linked GPCRs: mGluR7 as Prot(RMI)
    COLLEEN NISWENDER; Fiscal Year: 2007
    ..abstract_text> ..
  54. MOLECULAR MECHANISMS OF SCHWANN CELL MYELINATION
    Bruce Trapp; Fiscal Year: 2008
    ....
  55. Role of Endocannabinoids in the Behavioral Consequences of Social Isolation
    Daniele Piomelli; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  56. Chronic Cannabinoids, Tumor Growth and Hyperalgesia
    DARRYL HAMAMOTO; Fiscal Year: 2005
    ..Positive results from these studies would suggest that cannabinoids could be useful for the treatment of cancer pain. ..
  57. Oleylethanolamide derivatives as anti-obesity agents
    Daniele Piomelli; Fiscal Year: 2005
    ....
  58. Effort-related Functions of Nucleus Accumbens Adenosine A2A Receptors
    John D Salamone; Fiscal Year: 2010
    ....
  59. A Novel Animal Model of Relevance to Schizophrenia
    David Feifel; Fiscal Year: 2009
    ..The successful development of this animal model could significantly enhance the understanding of the underlying causes of schizophrenia-associated abnormalities and improve drug discovery. ..