spinal cord injuries

Summary

Summary: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).

Top Publications

  1. pmc Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord
    Kristina A Kigerl
    Center for Brain and Spinal Cord Repair, Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 29:13435-44. 2009
  2. ncbi A sensitive and reliable locomotor rating scale for open field testing in rats
    D M Basso
    Department of Cell Biology, Neurobiology and Anatomy, Ohio State University, Columbus, USA
    J Neurotrauma 12:1-21. 1995
  3. ncbi Regeneration beyond the glial scar
    Jerry Silver
    Department of Neurosciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Nat Rev Neurosci 5:146-56. 2004
  4. ncbi Repertoire of microglial and macrophage responses after spinal cord injury
    Samuel David
    The Research Institute of the McGill University Health Center, 1650 Cedar Avenue, Montreal, Quebec, Canada, H3G 1A4
    Nat Rev Neurosci 12:388-99. 2011
  5. pmc Transplantation of mesenchymal stem cells promotes an alternative pathway of macrophage activation and functional recovery after spinal cord injury
    Hideaki Nakajima
    Department of Orthopaedics and Rehabilitation Medicine, University of Fukui Faculty of Medical Sciences, Fukui, Japan
    J Neurotrauma 29:1614-25. 2012
  6. pmc Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice
    Ravid Shechter
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    PLoS Med 6:e1000113. 2009
  7. pmc Role of microglia in neurotrauma
    David J Loane
    Department of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research STAR, National Study Center for Trauma and EMS, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Neurotherapeutics 7:366-77. 2010
  8. ncbi Restoring voluntary control of locomotion after paralyzing spinal cord injury
    Rubia van den Brand
    Neurology Department, University of Zurich, Ch 8008 Zurich, Switzerland
    Science 336:1182-5. 2012
  9. ncbi The glial scar and central nervous system repair
    J W Fawcett
    Department of Physiology and MRC Cambridge Centre for Brain Repair, University of Cambridge, UK
    Brain Res Bull 49:377-91. 1999
  10. ncbi Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains
    D Michele Basso
    Division of Physical Therapy, School of Allied Medical Professions, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurotrauma 23:635-59. 2006

Detail Information

Publications335 found, 100 shown here

  1. pmc Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord
    Kristina A Kigerl
    Center for Brain and Spinal Cord Repair, Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 29:13435-44. 2009
    ....
  2. ncbi A sensitive and reliable locomotor rating scale for open field testing in rats
    D M Basso
    Department of Cell Biology, Neurobiology and Anatomy, Ohio State University, Columbus, USA
    J Neurotrauma 12:1-21. 1995
    ..The BBB Locomotor Rating Scale offers investigators a more discriminating measure of behavioral outcome to evaluate treatments after spinal cord injury...
  3. ncbi Regeneration beyond the glial scar
    Jerry Silver
    Department of Neurosciences, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Nat Rev Neurosci 5:146-56. 2004
  4. ncbi Repertoire of microglial and macrophage responses after spinal cord injury
    Samuel David
    The Research Institute of the McGill University Health Center, 1650 Cedar Avenue, Montreal, Quebec, Canada, H3G 1A4
    Nat Rev Neurosci 12:388-99. 2011
    ..Harnessing their anti-inflammatory properties could pave the way for new therapeutic strategies for spinal cord trauma...
  5. pmc Transplantation of mesenchymal stem cells promotes an alternative pathway of macrophage activation and functional recovery after spinal cord injury
    Hideaki Nakajima
    Department of Orthopaedics and Rehabilitation Medicine, University of Fukui Faculty of Medical Sciences, Fukui, Japan
    J Neurotrauma 29:1614-25. 2012
    ....
  6. pmc Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice
    Ravid Shechter
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    PLoS Med 6:e1000113. 2009
    ..The hypothesis of the current study is that a specific population of infiltrating monocyte-derived MPhi is functionally distinct from the inflammatory resident microglia and is essential for recovery from SCI...
  7. pmc Role of microglia in neurotrauma
    David J Loane
    Department of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research STAR, National Study Center for Trauma and EMS, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Neurotherapeutics 7:366-77. 2010
    ..In that light, future research is needed to focus on clarifying the signals and mechanisms by which microglia can be guided to promote optimal functional recovery...
  8. ncbi Restoring voluntary control of locomotion after paralyzing spinal cord injury
    Rubia van den Brand
    Neurology Department, University of Zurich, Ch 8008 Zurich, Switzerland
    Science 336:1182-5. 2012
    Half of human spinal cord injuries lead to chronic paralysis. Here, we introduce an electrochemical neuroprosthesis and a robotic postural interface designed to encourage supraspinally mediated movements in rats with paralyzing lesions...
  9. ncbi The glial scar and central nervous system repair
    J W Fawcett
    Department of Physiology and MRC Cambridge Centre for Brain Repair, University of Cambridge, UK
    Brain Res Bull 49:377-91. 1999
    ....
  10. ncbi Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains
    D Michele Basso
    Division of Physical Therapy, School of Allied Medical Professions, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurotrauma 23:635-59. 2006
    ..05). The differing behavioral response to SCI suggests inherent genetic factors significantly impact locomotor recovery and must be considered in studies with inbred or genetically engineered mouse strains...
  11. ncbi Reactive astrocytes protect tissue and preserve function after spinal cord injury
    Jill R Faulkner
    Department of Neurobiology, University of California, Los Angeles, California 90095 1763, USA
    J Neurosci 24:2143-55. 2004
    ....
  12. ncbi Therapeutic interventions after spinal cord injury
    Sandrine Thuret
    Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King s College London, P O Box 39, 1 2 WW Ground, Denmark Hill, London SE5 8AF, UK
    Nat Rev Neurosci 7:628-43. 2006
    ..Basic scientific research should provide a rational basis for tailoring specific combinations of clinical therapies to different types of SCI...
  13. pmc Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study
    Susan Harkema
    Department of Neurological Surgery, Kentucky Spinal Cord Research Center, University of Louisville, KY, USA
    Lancet 377:1938-47. 2011
    ....
  14. pmc Transformation of nonfunctional spinal circuits into functional states after the loss of brain input
    Gregoire Courtine
    Neurology Department, University of Zurich, Zurich, Switzerland
    Nat Neurosci 12:1333-42. 2009
    ..These findings provide a strategy by which individuals with spinal cord injuries could regain substantial levels of motor control.
  15. pmc Disability, atrophy and cortical reorganization following spinal cord injury
    Patrick Freund
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK
    Brain 134:1610-22. 2011
    ..The degree of cortical reorganization is predicted by spinal atrophy and is associated with significant disability...
  16. ncbi Epidemiology of traumatic spinal cord injury: trends and future implications
    M J DeVivo
    National Spinal Cord Injury Statistical Center, Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, AL 35233 7330, USA
    Spinal Cord 50:365-72. 2012
    ..Review supplemented by inception cohort...
  17. ncbi Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury
    Tiziana Genovese
    IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
    J Pharmacol Exp Ther 326:12-23. 2008
    ..Together, the results indicate that PEA reduces inflammation and tissue injury associated with SCI and suggest a regulatory role for endogenous PPAR-alpha signaling in the inflammatory response associated with spinal cord trauma...
  18. ncbi Origin of new glial cells in intact and injured adult spinal cord
    Fanie Barnabe-Heider
    Department of Cell and Molecular Biology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Cell Stem Cell 7:470-82. 2010
    ..We provide an integrated view of how several distinct cell types contribute in complementary ways to cell maintenance and the reaction to injury...
  19. pmc Spinal cord injury reveals multilineage differentiation of ependymal cells
    Konstantinos Meletis
    Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
    PLoS Biol 6:e182. 2008
    ..Modulating the fate of ependymal progeny after spinal cord injury may offer an alternative to cell transplantation for cell replacement therapies in spinal cord injury...
  20. ncbi The bright side of the glial scar in CNS repair
    Asya Rolls
    Asya Rolls, Ravid Shechter and Michal Schwartz are at the Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Nat Rev Neurosci 10:235-41. 2009
    ..However, increasing evidence suggests a beneficial role for this scar tissue as part of the endogenous local immune regulation and repair process. How can these opposing effects be reconciled? Perhaps it is all a matter of timing...
  21. pmc Axonal integrity predicts cortical reorganisation following cervical injury
    Patrick Freund
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 83:629-37. 2012
    ..Traumatic spinal cord injury (SCI) leads to disruption of axonal architecture and macroscopic tissue loss with impaired information flow between the brain and spinal cord-the presumed basis of ensuing clinical impairment...
  22. pmc Functional regeneration of respiratory pathways after spinal cord injury
    Warren J Alilain
    Department of Neurosciences, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, Ohio 44106, USA
    Nature 475:196-200. 2011
    b>Spinal cord injuries often occur at the cervical level above the phrenic motor pools, which innervate the diaphragm...
  23. pmc STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury
    Julia E Herrmann
    Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 28:7231-43. 2008
    ..These findings indicate that STAT3 signaling is a critical regulator of certain aspects of reactive astrogliosis and provide additional evidence that scar-forming astrocytes restrict the spread of inflammatory cells after SCI...
  24. ncbi A pericyte origin of spinal cord scar tissue
    Christian Goritz
    Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
    Science 333:238-42. 2011
    ..The formation of connective tissue is common to many injuries and pathologies, and here we demonstrate a cellular origin of fibrosis...
  25. pmc A systematic review of cellular transplantation therapies for spinal cord injury
    Wolfram Tetzlaff
    University of British Columbia, ICORD, Vancouver, British Columbia, Canada
    J Neurotrauma 28:1611-82. 2011
    ..With respect to the timing of intervention, nearly all of the studies reviewed were conducted with transplantations occurring subacutely and acutely, while chronic treatments were rare and often failed to yield functional benefits...
  26. pmc Retraining the injured spinal cord
    V R Edgerton
    Brain Research Institute and Departments of Physiological Science and Neurobiology, University of California, Los Angeles, CA 90095, USA
    J Physiol 533:15-22. 2001
    ..These concepts and observations demonstrate that (a) the spinal cord can interpret complex afferent information and generate the appropriate motor task; and (b) motor ability can be defined to a large degree by training...
  27. pmc Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment
    Kevin D Beck
    Anatomy and Neurobiology, University of California, Irvine, CA 92697 4292, USA
    Brain 133:433-47. 2010
    ....
  28. pmc Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice
    Brian J Cummings
    Department of Physical Medicine and Rehabilitation, Reeve Irvine Research Center, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 102:14069-74. 2005
    ..Glial fibrillary acidic protein-positive astrocytic differentiation was rare, and hCNS-SCns did not appear to contribute to the scar. These data suggest that hCNS-SCns may possess therapeutic potential for CNS injury and disease...
  29. ncbi Proinflammatory cytokine synthesis in the injured mouse spinal cord: multiphasic expression pattern and identification of the cell types involved
    Isabelle Pineau
    Department of Anatomy and Physiology, Laval University, Ste Foy, Quebec, Canada G1V 4G2
    J Comp Neurol 500:267-85. 2007
    ..Overall, these results indicate that following SCI, all classes of neural cells initially contribute to the organization of inflammation, whereas recruited immune cells mostly contribute to its maintenance at later time points...
  30. pmc Influence of a locomotor training approach on walking speed and distance in people with chronic spinal cord injury: a randomized clinical trial
    Edelle C Field-Fote
    Department of Physical Therapy, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Phys Ther 91:48-60. 2011
    ..Impaired walking limits function after spinal cord injury (SCI), but training-related improvements are possible even in people with chronic motor incomplete SCI...
  31. ncbi Chondroitinase ABC promotes functional recovery after spinal cord injury
    Elizabeth J Bradbury
    Sensory Function Group, Centre for Neuroscience Research, Hodgkin Building, Kings College London, Guy s Campus, London Bridge, London SE1 1UL, UK
    Nature 416:636-40. 2002
    ..Our results demonstrate that CSPGs are important inhibitory molecules in vivo and suggest that their manipulation will be useful for treatment of human spinal injuries...
  32. pmc PTEN deletion enhances the regenerative ability of adult corticospinal neurons
    Kai Liu
    F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 13:1075-81. 2010
    ..Thus, modulating neuronal intrinsic PTEN/mTOR activity represents a potential therapeutic strategy for promoting axon regeneration and functional repair after adult spinal cord injury...
  33. ncbi Anti-TNF therapy in the injured spinal cord
    Emanuela Esposito
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica Policlinico Universitario Via C Valeria Gazzi 98100 Messina, Italy
    Trends Pharmacol Sci 32:107-15. 2011
    ..g. thalidomide) and discuss their potential as therapy for SCI...
  34. pmc Spinal cord injury: a systematic review of current treatment options
    David W Cadotte
    Division of Neurosurgery, University of Toronto, and Neural Repair and Regeneration, Spinal Program, University Health Network, Toronto Western Hospital, Toronto, ON, Canada
    Clin Orthop Relat Res 469:732-41. 2011
    ..Research has revealed an understanding of mechanisms that occur after the primary injury and contribute to functional loss. By targeting these secondary mechanisms of injury, clinicians may be able to offer improved recovery after SCI...
  35. ncbi Activated microglia contribute to the maintenance of chronic pain after spinal cord injury
    Bryan C Hains
    Department of Neurology, Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 26:4308-17. 2006
    ..These results suggest an important role for activated microglia in the maintenance of chronic central below-level pain after SCI and support the newly emerging role of non-neuronal immune cells as a contributing factor in post-SCI pain...
  36. ncbi Plasticity of the spinal neural circuitry after injury
    V Reggie Edgerton
    Brain Research Institute, University of California, Los Angeles, California 90095, USA
    Annu Rev Neurosci 27:145-67. 2004
    ..Rehabilitative efforts combining locomotor training pharmacological means and/or spinal cord electrical stimulation paradigms will most likely result in more effective methods of recovery than using only one intervention...
  37. ncbi Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury
    Kristina A Kigerl
    Integrated Biomedical Science Graduate Program, College of Medicine, Ohio State University, Columbus, Ohio, USA
    J Neurochem 102:37-50. 2007
    ..Together, these data suggest that in the absence of pathogens, TLR2 and TLR4 are important for coordinating post-injury sequelae and perhaps in regulating inflammation and gliosis after SCI...
  38. ncbi The cellular inflammatory response in human spinal cords after injury
    Jennifer C Fleming
    BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada
    Brain 129:3249-69. 2006
    ....
  39. pmc IL-10 promotes neuronal survival following spinal cord injury
    Zhigang Zhou
    Department of Neurology, University of Michigan and Ann Arbor VA Healthcare System, 5027 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Exp Neurol 220:183-90. 2009
    ....
  40. ncbi Post-traumatic inflammation following spinal cord injury
    O N Hausmann
    Neurosurgical Department, University Clinics Basel, Switzerland
    Spinal Cord 41:369-78. 2003
    ..This review summarizes the current knowledge concerning the structural features (vascular, cellular, and biochemical events) of SCI and gives an overview of the regulation of post-traumatic inflammation...
  41. pmc Cell death after spinal cord injury is exacerbated by rapid TNF alpha-induced trafficking of GluR2-lacking AMPARs to the plasma membrane
    Adam R Ferguson
    Brain and Spinal Injury Center, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94110, USA
    J Neurosci 28:11391-400. 2008
    ....
  42. ncbi International standards for neurological classification of spinal cord injury
    Ralph J Marino
    J Spinal Cord Med 26:S50-6. 2003
  43. pmc Stem cells in human neurodegenerative disorders--time for clinical translation?
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Wallenberg Neuroscience Center, University Hospital, Lund, Sweden
    J Clin Invest 120:29-40. 2010
    ..In particular, we need to better understand the mechanisms of action of stem cells after transplantation and learn how to control stem cell proliferation, survival, migration, and differentiation in the pathological environment...
  44. ncbi Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats
    P G Popovich
    Department of Physiology, College of Medicine, Ohio State University, Columbus 43210, USA
    J Comp Neurol 377:443-64. 1997
    ..These strain-specific findings potentially represent differences in corticosteroid regulation of immunity and may help predict a range of functional neurologic consequences affected by neuroimmune interactions...
  45. ncbi Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury
    Soheila Karimi-Abdolrezaee
    Division of Cell and Molecular Biology, Toronto Western Research Institute, Krembil Neuroscience Center, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 26:3377-89. 2006
    ..Our data provide strong evidence in support of the feasibility of adult NPCs for cell-based remyelination after SCI...
  46. pmc Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors
    Katherine C Murray
    Centre for Neuroscience, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada
    Nat Med 16:694-700. 2010
    ..Accordingly, blocking constitutively active 5-HT2C receptors with SB206553 or cyproheptadine, in both rats and humans, largely eliminates these calcium currents and muscle spasms, providing a new rationale for antispastic drug therapy...
  47. pmc Multipotent adult progenitor cells prevent macrophage-mediated axonal dieback and promote regrowth after spinal cord injury
    Sarah A Busch
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 31:944-53. 2011
    ..Our results demonstrate that MAPCs have therapeutic benefits after spinal cord injury and provide specific evidence that adult stem cells exert positive immunomodulatory and neurotrophic influences...
  48. ncbi In vivo imaging of axonal degeneration and regeneration in the injured spinal cord
    Martin Kerschensteiner
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Med 11:572-7. 2005
    ..These results suggest that time-lapse imaging of spinal cord injury may provide a powerful analytical tool for assessing the pathogenesis of spinal cord injury and for evaluating therapies that enhance regeneration...
  49. pmc Fate of transplanted bone marrow derived mesenchymal stem cells following spinal cord injury in rats by transplantation routes
    Eun Sun Kang
    Department of Orthopedic Surgery, Seoul St Mary s Hosptial, College of Medicine, The Catholic University of Korea, Seoul, Korea
    J Korean Med Sci 27:586-93. 2012
    ..1, and 8.5 ± 2.8, respectively. Regardless of the delivery route, the MSCs transplantation following spinal cord injuries presented better behavioral improvement...
  50. ncbi Cotransplantation of mouse neural stem cells (mNSCs) with adipose tissue-derived mesenchymal stem cells improves mNSC survival in a rat spinal cord injury model
    Jin Soo Oh
    Department of Neurosurgery, Spine and Spinal Cord Institute, College of Medicine, Yonsei University, Seoul, Korea
    Cell Transplant 20:837-49. 2011
    ..These findings suggest that cotransplantation of mNSCs with AT-MSCs may be a more effective transplantation protocol to improve the survival of cells transplanted into the injured spinal cord...
  51. ncbi Tumor necrosis factor-α antagonist reduces apoptosis of neurons and oligodendroglia in rat spinal cord injury
    Ke Bing Chen
    Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Japan
    Spine (Phila Pa 1976) 36:1350-8. 2011
    ..To examine the effects of a tumor necrosis factor (TNF)-α antagonist (etanercept) on rat spinal cord injury and identify a possible mechanism for its action...
  52. pmc Functional role of exercise-induced cortical organization of sensorimotor cortex after spinal transection
    T Kao
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    J Neurophysiol 106:2662-74. 2011
    ..We hypothesize that this increased activity is related to the ability of the animal to take weight supported steps and that, therefore, these changes in cortical organization after spinal cord injury are relevant for functional recovery...
  53. ncbi N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice show better functional recovery after spinal cord injury
    Zenya Ito
    Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Neurosci 30:5937-47. 2010
    ..N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice are a good model to investigate the roles of keratan sulfate in the CNS...
  54. pmc Spinal cord injury immediately changes the state of the brain
    Juan Aguilar
    Hospital Nacional de Paraplejicos, Servicio de Salud de Castilla La Mancha, Toledo, Spain
    J Neurosci 30:7528-37. 2010
    ....
  55. ncbi Evidence for a spinal central pattern generator in humans
    M R Dimitrijevic
    Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas 77030, USA
    Ann N Y Acad Sci 860:360-76. 1998
    ....
  56. pmc Grafted neural progenitors integrate and restore synaptic connectivity across the injured spinal cord
    Joseph F Bonner
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 31:4675-86. 2011
    ..These findings provide the first evidence for the ability of NPC to form a neuronal relay by extending active axons across the injured spinal cord to the intended target establishing a critical step for neural repair with stem cells...
  57. ncbi Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat
    Von R King
    Institute of Cell and Molecular Science, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, United Kingdom
    J Neurosci 26:4672-80. 2006
    ..In contrast, the use of preparations enriched in omega-6 PUFAs after injury could worsen outcome after SCI...
  58. pmc Concise review: Bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications
    Karina T Wright
    Spinal Studies and Midlands Centre for Spinal Injuries, RJAH Orthopaedic Hospital, Oswestry, Shropshire, United Kingdom
    Stem Cells 29:169-78. 2011
    ..We then discuss some of the specific issues related to the translation of HSC and MSC therapies for patients with SCI and present a comprehensive critique of the current bone marrow cell clinical trials for the treatment of SCI to date...
  59. ncbi Cortical sensory map rearrangement after spinal cord injury: fMRI responses linked to Nogo signalling
    Toshiki Endo
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Brain 130:2951-61. 2007
    ..In such situations, methods to control cortical plasticity, possibly by targeting Nogo signalling, may become helpful...
  60. ncbi Efficient differentiation of human embryonic stem cells into oligodendrocyte progenitors for application in a rat contusion model of spinal cord injury
    Candace L Kerr
    Department of Gynecology and Obstetrics and Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Int J Neurosci 120:305-13. 2010
    ..The extent of injury and effect of early cell transplant was measured using behavioral and electrophysiological assessments which demonstrated increased neurological responses in rats transplanted with OPCs compared to controls...
  61. pmc Transplanted oligodendrocytes and motoneuron progenitors generated from human embryonic stem cells promote locomotor recovery after spinal cord transection
    Slaven Erceg
    Cellular Reprogramming Laboratory, Centro de Investigación Príncipe Felipe CIPF, Valencia, Spain
    Stem Cells 28:1541-9. 2010
    ..Taken together, these results indicate that OPC and MP derived from hESC could be a useful therapeutic strategy to repair injured spinal cord...
  62. pmc The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury
    Sari S Hannila
    Department of Biological Sciences, Hunter College, City University of New York, New York, NY 10021, USA
    Exp Neurol 209:321-32. 2008
    ..Further study of these genes, in combination with human clinical trials of existing agents such as rolipram, would allow the therapeutic potential of cAMP to be fully realized...
  63. ncbi Neuroprotective features of mesenchymal stem cells
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genoa, Italy
    Best Pract Res Clin Haematol 24:59-64. 2011
    ..This review discusses the targets and mechanisms of BM-MSC mediated neuroprotection...
  64. ncbi Functional and electrophysiological changes after graded traumatic spinal cord injury in adult rat
    Qilin Cao
    Kentucky Spinal Cord Injury Research Center, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA Department of Neurological Surgery, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Exp Neurol 191:S3-S16. 2005
    ..These data support the notion that widespread WM damage in the ventral and lateral funiculi may be a major cause for locomotor deficits and lack of tcMMEP responses after SCI...
  65. ncbi Astrocyte intermediate filaments in CNS pathologies and regeneration
    Milos Pekny
    Department of Medical Biochemistry, Sahlgrenska Academy at Goteborg University, Box 430, 405 30 Goteborg, Sweden
    J Pathol 204:428-37. 2004
    ..GFAP is the principal astrocyte intermediate filament protein and dominant mutations in the GFAP gene have been shown to lead to Alexander disease, a fatal neurodegenerative condition in humans...
  66. ncbi Acute cervical traumatic spinal cord injury: MR imaging findings correlated with neurologic outcome--prospective study with 100 consecutive patients
    Firoz Miyanji
    Spinal Program, Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, 399 Bathurst St, West Wing, 4th Floor, Room 449, Toronto, Ontario, Canada
    Radiology 243:820-7. 2007
    ..To prospectively evaluate whether quantitative and qualitative magnetic resonance (MR) imaging assessments after spinal cord injury (SCI) correlate with patient neurologic status and are predictive of outcome at long-term follow-up...
  67. pmc Timing in the absence of supraspinal input II: regularly spaced stimulation induces a lasting alteration in spinal function that depends on the NMDA receptor, BDNF release, and protein synthesis
    Kyle M Baumbauer
    Department of Psychology, Texas A and M University, College Station, Texas 77843 4325, USA
    J Neurosci 29:14383-93. 2009
    ..The results suggest that spinal systems can detect regularity and that this type of stimulation promotes adaptive plasticity, which may foster recovery after spinal injury...
  68. ncbi LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis
    Sha Mi
    Biogen Idec Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Med 13:1228-33. 2007
    ..Antagonism of LINGO-1 or its pathway is therefore a promising approach for the treatment of demyelinating diseases of the CNS...
  69. ncbi Instrumental learning within the spinal cord: underlying mechanisms and implications for recovery after injury
    James W Grau
    Department of Psychology, Texas A and M University, College Station, TX 77843 4235, USA
    Behav Cogn Neurosci Rev 5:191-239. 2006
    ..Uncontrollable, but not controllable, stimulation impairs the recovery of function after a contusion injury...
  70. pmc BDNF and learning: Evidence that instrumental training promotes learning within the spinal cord by up-regulating BDNF expression
    F Gomez-Pinilla
    Division of Neurosurgery, UCLA Brain Injury Research Center, USA
    Neuroscience 148:893-906. 2007
    ..The findings indicate that instrumental training enables learning and elevates BDNF mRNA levels within the lumbar spinal cord. BDNF is both necessary, and sufficient, to produce the enabling effect...
  71. pmc Two chronic motor training paradigms differentially influence acute instrumental learning in spinally transected rats
    Allison J Bigbee
    Department of Neurology, University of California at Los Angeles, Los Angeles, CA 90095 1769, United States
    Behav Brain Res 180:95-101. 2007
    ....
  72. ncbi Degenerative and regenerative mechanisms governing spinal cord injury
    Christos Profyris
    Motor Neuron Disease and Paralysis Laboratory, Neural Injury and Repair Group, The Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria 3010, Australia
    Neurobiol Dis 15:415-36. 2004
    ....
  73. ncbi Cell death in models of spinal cord injury
    Michael S Beattie
    Department of Neuroscience, The Ohio State University Medical Center, 333 W 10th Avenue, Columbus, OH 43210, USA
    Prog Brain Res 137:37-47. 2002
    ..Continued study of both contusion models and other new approaches to studying these mechanisms will be needed to maximize strategies for acute and chronic therapies, and for neural repair...
  74. pmc Repulsive Wnt signaling inhibits axon regeneration after CNS injury
    Yaobo Liu
    Neurobiology Section, Biological Sciences Division, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 28:8376-82. 2008
    ..Therefore, repulsive Wnt signaling may be a cause of cortical spinal tract axon retraction and inhibits axon sprouting after injury...
  75. ncbi Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and p75 expression following spinal cord injury in the rat
    S Casha
    Division of Neurosurgery, Toronto Western Research, The University Health Network, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Neuroscience 103:203-18. 2001
    ..Activation of the FAS and p75 death receptor pathways may be involved in initiating this process...
  76. ncbi Bone marrow stromal cells infused into the cerebrospinal fluid promote functional recovery of the injured rat spinal cord with reduced cavity formation
    Masayoshi Ohta
    Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Exp Neurol 187:266-78. 2004
    ....
  77. ncbi Skin-derived precursors generate myelinating Schwann cells that promote remyelination and functional recovery after contusion spinal cord injury
    Jeff Biernaskie
    Developmental and Stem Cell Biology Group, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1L7
    J Neurosci 27:9545-59. 2007
    ..Thus, SKP-derived SCs provide an accessible, potentially autologous source of cells for transplantation into and treatment of the injured spinal cord...
  78. ncbi The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration
    Eugene Park
    Division of Neurosurgery and Institute of Medical Science, University of Toronto, and Division of Cell and Molecular Biology, Toronto Western Research Institute, Toronto Western Hospital, University Health Network, Ontario, Canada
    J Neurotrauma 21:754-74. 2004
    ..The latter mechanism appears key to glutamatergic white matter degeneration after SCI and may represent an attractive therapeutic target...
  79. ncbi Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury
    Hong Yang
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0626, USA
    J Neurosci 26:2157-66. 2006
    ..Thus, cell replacement is an extensive natural compensatory response to injury in the primate spinal cord that contributes to neural repair and is a potential target for therapeutic enhancement...
  80. ncbi Synergistic effects of transplanted adult neural stem/progenitor cells, chondroitinase, and growth factors promote functional repair and plasticity of the chronically injured spinal cord
    Soheila Karimi-Abdolrezaee
    Division of Genetics and Development, Toronto Western Research Institute and Krembil Neuroscience Center, University Health Network, Toronto, Ontario M5T 2S8, Canada
    J Neurosci 30:1657-76. 2010
    ..These findings could potentially bring us closer to the application of NPCs for patients suffering from chronic SCI or other conditions characterized by the formation of a glial scar...
  81. ncbi Epidemiology, demographics, and pathophysiology of acute spinal cord injury
    L H Sekhon
    Department of Neurosurgery, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia
    Spine (Phila Pa 1976) 26:S2-12. 2001
    ..This review examines the epidemiology, demographics, and pathophysiology of acute spinal cord injury...
  82. ncbi Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats
    Dai Shi Tian
    Department of Neurology, Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, PR China
    Brain Res 1135:177-85. 2007
    ..Our findings suggest that modulation of microglial proliferation with associated proinflammatory cytokine expression may be a mechanism of cell cycle inhibition-mediated neuroprotections in the CNS trauma...
  83. ncbi Targeting recovery: priorities of the spinal cord-injured population
    Kim D Anderson
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697 4292, USA
    J Neurotrauma 21:1371-83. 2004
    ..In order to improve the relevance of research in this area, the concerns of the SCI population must be better known and taken into account. This approach is consistent with and emphasized by the new NIH roadmap to discovery...
  84. pmc Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury
    Roberta Brambilla
    The Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Exp Med 202:145-56. 2005
    ....
  85. ncbi BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury
    P Lu
    Department of Neurosciences and Center for Neural Repair, University of California at San Diego, La Jolla, CA 92093 0626, USA
    Exp Neurol 191:344-60. 2005
    ..Combination therapy with other experimental approaches will likely be required to achieve axonal growth beyond the lesion site and functional recovery...
  86. ncbi Incidence, prevalence and epidemiology of spinal cord injury: what learns a worldwide literature survey?
    M Wyndaele
    Department of Urology, University Hospital Antwerp, Edegem, Belgium
    Spinal Cord 44:523-9. 2006
    ..Literature survey...
  87. ncbi Transplantation of human embryonic stem cell-derived oligodendrocyte progenitors into rat spinal cord injuries does not cause harm
    Frank Cloutier
    University of California at Irvine, Reeve Irvine Research Center, Department of Anatomy, College of Medicine, 2111 Gillespie Neuroscience Research Facility, Irvine, CA 92697 4292, USA
    Regen Med 1:469-79. 2006
    ..In addition, our results indicate that transplantation of human embryonic stem cell-derived oligodendrocyte progenitor cells into the injured spinal cord is not associated with a decline in locomotor function...
  88. ncbi Treatment of a mouse model of spinal cord injury by transplantation of human induced pluripotent stem cell-derived long-term self-renewing neuroepithelial-like stem cells
    Yusuke Fujimoto
    Laboratory of Molecular Neuroscience, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Japan
    Stem Cells 30:1163-73. 2012
    ..Our findings indicate that hiPS-lt-NES transplantation represents a promising avenue for effective cell-based treatment of SCI...
  89. pmc Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS)
    Michael G Fehlings
    Divisions of Neurosurgery and Orthopedic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 7:e32037. 2012
    ..Our objective was to evaluate the relative effectiveness of early (<24 hours after injury) versus late (≥ 24 hours after injury) decompressive surgery after traumatic cervical SCI...
  90. ncbi Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation
    Guillermo Garcia-Alias
    Centre for Brain Repair, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK
    Nat Neurosci 12:1145-51. 2009
    ..combined with physical rehabilitation promotes recovery of manual dexterity in rats with cervical spinal cord injuries. Rats received a C4 dorsal funiculus cut followed by chondroitinase ABC or penicillinase as a control...
  91. ncbi Changes in supraspinal activation patterns following robotic locomotor therapy in motor-incomplete spinal cord injury
    Patricia Winchester
    University of Texas Southwestern Medical Center, Department of Physical Therapy, Dallas, TX 75390 8876, USA
    Neurorehabil Neural Repair 19:313-24. 2005
    ..The purpose of this study was to evaluate the potential for supraspinal reorganization associated with 12 weeks of robotic BWSTT using functional magnetic resonance imaging (fMRI)...
  92. ncbi Progressive damage after brain and spinal cord injury: pathomechanisms and treatment strategies
    Helen M Bramlett
    Department of Neurological Surgery, Neurotrauma Research Center, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA
    Prog Brain Res 161:125-41. 2007
    ..This chapter summarizes some of the recent data regarding progressive damage after CNS trauma and mechanisms underlying these changes...
  93. pmc Interaction of NG2(+) glial progenitors and microglia/macrophages from the injured spinal cord
    Junfang Wu
    Department of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia, USA
    Glia 58:410-22. 2010
    ..Thus, the nonreplacement of lost glial cells in the central lesion zone may involve, at least in part, inhibitory factors produced by microglia/macrophages that are concentrated within the lesion...
  94. ncbi Strategies to restore motor functions after spinal cord injury
    Pascale Boulenguez
    Laboratoire Plasticité et Physio Pathologie de Motricité UMR6196, Centre National de Recherche Scientifique CNRS and Aix Marseille Université, CNRS, 31 Chemin Joseph Aiguier, F 13402 Marseille cx 20, France
    Curr Opin Neurobiol 19:587-600. 2009
    ..Finally, improvements in the understanding of the mechanisms underlying spasticity may lead to new treatments of this disabling complication affecting patients with SCI...
  95. ncbi CatWalk-assisted gait analysis in the assessment of spinal cord injury
    Frank P T Hamers
    Rudolf Magnus Institute of Neuroscience, Department of Oto Rhino Laryngology, Utrecht, The Netherlands
    J Neurotrauma 23:537-48. 2006
    ..Therefore, a major part of this review is devoted to the history and meaning of these coordination measures...
  96. ncbi Results of a phase II placebo-controlled randomized trial of minocycline in acute spinal cord injury
    Steven Casha
    Department of Clinical Neurosciences and the Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada
    Brain 135:1224-36. 2012
    ..Although this study does not establish the efficacy of minocycline in spinal cord injury the findings are encouraging and warrant further investigation in a multi-centre phase III trial. ClinicalTrials.gov number NCT00559494...
  97. pmc A systematic review of non-invasive pharmacologic neuroprotective treatments for acute spinal cord injury
    Brian K Kwon
    University of British Columbia, Combined Neurosurgical and Orthopaedic Spine Program, Department of Orthopaedics, Vancouver, British Columbia, Canada
    J Neurotrauma 28:1545-88. 2011
    ..The review highlights the extent of investigation that has occurred in these specific therapies, and points out gaps in our knowledge that would be potentially valuable prior to human translation...
  98. ncbi Bone marrow stromal cell transplantation for treatment of sub-acute spinal cord injury in the rat
    Chizuka Ide
    Department of Occupational Therapy, Faculty of Nursing and Rehabilitation, Aino University, Higashi Ohda, 4 5 4, Ibaragi City, Osaka, Japan
    Brain Res 1332:32-47. 2010
    ..5-5.7 in the control. BMSC transplantation into lesions of advanced SCI has markedly beneficial effects on tissue repair and axonal outgrowth, leading to improved locomotion in rats...
  99. ncbi Basic concepts of activity-based interventions for improved recovery of motor function after spinal cord injury
    Roland R Roy
    Department of Integrative Biology and Physiology and the Brain Research Institute, University of California, Los Angeles, CA, USA
    Arch Phys Med Rehabil 93:1487-97. 2012
    ..Herein, we provide a brief review of some of the neurophysiologic rationale for the success of these interventions...
  100. ncbi Factors associated with improved neurologic outcomes in patients with incomplete tetraplegia
    Matthew E Pollard
    Department of Orthopaedic Surgery, Atlanta Medical Center, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 28:33-9. 2003
    Retrospective review of 412 patients with traumatic, incomplete, cervical spinal cord injuries, and an average follow-up period of 2 years.
  101. pmc Glial inhibition of CNS axon regeneration
    Glenn Yiu
    Division of Neuroscience, Children s Hospital, Boston, Massachusetts 02115, USA
    Nat Rev Neurosci 7:617-27. 2006
    ..Greater insight into glial inhibition is crucial for developing therapies to promote functional recovery after neural injury...

Research Grants75

  1. Chronic Electrical Stimulation to Reduce Bladder Hyperreflexia after SCI
    Kenneth J Gustafson; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Although about 11% of Americans are veterans, 25% of all individuals with spinal cord injuries (SCIs) in the US are veterans. Neurogenic bladder is a common neurologic complication associated with SCI...
  2. Effects of brain-selective estradiol on gene expression and female sex behavior
    Kim Wallen; Fiscal Year: 2013
    ..If successful these studies will revolutionize the treatment of clinical problems resulting from hypoestrogenic conditions. ..
  3. Optimization of EphA4 antagonists for CNS disorders
    ELENA B contact PASQUALE; Fiscal Year: 2010
    ..this, recent studies suggest that inhibiting EphA4-ephrin interaction could be useful for the treatment of spinal cord injuries. Finally, recent work has implicated ephrin-A3 and another EphA4 ligand, ephrin-A2, in maintaining the ..
  4. Neural Representation of Reach-to-Grasp for Cortical FES Neuroprostheses
    Abidemi Bolu Ajiboye; Fiscal Year: 2012
    ..RELEVANCE Although about 11% of Americans are Veterans, they comprise almost 20% of all individuals with spinal cord injuries. Individuals who have experienced high cervical spinal cord injury, or other severely paralyzing ..
  5. Enhancing Plasticity in Damaged Spinal Cord to Repair Transmission and Function
    Victor L Arvanian; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Many soldiers return home with contusive spinal cord injuries (SCI), mostly due to the powerful explosives used in the improvised bombs that rattle U.S. troops inside heavily armored vehicles...
  6. Stem cells for novel gene delivery of nitric oxide in the gut
    Hiroshi Mashimo; Fiscal Year: 2013
    ..not only in the gut, but in a wide range pathologies prevalent in our aging Veteran population such as spinal cord injuries, male impotence, urinary incontinence in which nitric oxide play a major role, and in a wide range of ..
  7. Cell Cycle Pathways and Spinal Cord Injury
    ALAN IRA FADEN; Fiscal Year: 2011
    ..therapeutically relevant, delayed systemic administration of Flavopiridol improves post-traumatic function and histological outcome. ..
  8. A zebrafish model for neural regeneration
    ALLISON F ROSENBERG; Fiscal Year: 2012
    Patients with traumatic peripheral nerve or spinal cord injuries (250,000 Americans alone) require extensive medical treatment...
  9. MOLECULAR AND GENETIC ANALYSIS OF GPR126 IN PERIPHERAL NERVE.
    Kelly R Monk; Fiscal Year: 2013
    ....
  10. Transcriptional regulation of neuronal differentiation
    Bennett G Novitch; Fiscal Year: 2013
    ..function underlies several devastating neurodegenerative diseases as well as a failure to recover from spinal cord injuries. Currently, few therapies exist to treat these conditions, though great hope has been placed on using stem ..
  11. SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITY
    Xiang Yang Chen; Fiscal Year: 2012
    ..This project is revealing the mechanisms of these reflex changes, and showing how they can be induced and guided to increase recovery of function after spinal cord injury or with other injury or disease. ..
  12. Hands-Free Assistive Reading Technology for Persons with Disabilities
    IRENE SANDRA SCHIPPER; Fiscal Year: 2010
    ..Included in this population, for example, are patients who have suffered cerebrovascular accidents, spinal cord injuries, amyotrophic lateral sclerosis (ALS), multiple sclerosis, cerebral palsy, and arthritic joint changes...
  13. Effect of Intense Multi-Modal Training on Bone Mineral Density, Bone Biomarkers,
    Todd Anthony Astorino; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): PROJECT SUMMARY Approximately 11,000 spinal cord injuries (SCI) occur annually, with 80 % of injuries occurring in men...
  14. A Novel Surface Sensing Pathway in Proteus mirabilis
    Philip N Rather; Fiscal Year: 2013
    ..in patients undergoing extensive catheterization, such as elderly nursing home patients and those with spinal cord injuries. When grown on solid surfaces, such as Foley catheters or agar plates, P...
  15. Novel modalities for assessing the cortical tissue-electrode interface
    Jeffrey R Capadona; Fiscal Year: 2010
    ..could restore function to patients with motor deficiencies including individuals who have suffered from spinal cord injuries (~15,000/yr in the US) or stroke (750,000/yr in the US);of which a significant population are veterans...
  16. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith S Eisen; Fiscal Year: 2012
    ..a model to understand normal motoneuron development;this knowledge is critical for designing therapies for spinal cord injuries and diseases such as ALS...
  17. Profiling human reactive astrocytes for neurotrauma biomarkers
    Ina Beate Wanner; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Neurotrauma encompasses patients with a range of traumatic brain and spinal cord injuries including soldiers with blast inflicted injury, infants with the often undiagnosed shaken baby syndrome and ..
  18. Cervical spinal injury and demyelination in aged rats
    Michael S Beattie; Fiscal Year: 2010
    ..cord injury (SCI) is changing, with more and more aged individuals showing up at emergency rooms with spinal cord injuries, especially cervical SCIs related to falls (Ho et al, 2007)...
  19. Intrathecal therapy for autonomic dysreflexia
    Paul C Dolber; Fiscal Year: 2013
    ..They may additionally lay the foundation for investigation of descending neurotransmitter delivery by intraspinal neuronal grafts. ..
  20. EVALUATION OF AXONAL INTEGRITY USING DIFFUSION TENSOR IMAGING
    Wilson Z Ray; Fiscal Year: 2013
    ..A major shortcoming limiting efforts to improve the treatment of patients with spinal cord injuries is the lack of quantifiable metrics on which to base clinical decisions...
  21. Myelin Composition Influence on Bilayer Interactions in Multiple Sclerosis
    Jacob N Israelachvili; Fiscal Year: 2010
    ..that polyethylene glycol (PEG) and poloxamers, non-toxic and FDA-approved polymers, recently used to treat spinal cord injuries in animals, might act to heal the myelin sheath via adding an attractive osmotic 'depletion'force ..
  22. Identifying transcription factors expressed by ventral spinal cord interneurons
    KATHARINE EMMA LEWIS; Fiscal Year: 2013
    ..This is a critical gap in our knowledge as it dramatically impedes our ability to treat spinal cord injuries and neuronal diseases that affect locomotion...
  23. Regulation of Ptf1a in the Developing Nervous System
    David M Meredith; Fiscal Year: 2010
    ..Furthermore, the advancement in our understanding of how spinal neurons are formed should accelerate the progress in treating spinal cord trauma. ..
  24. Bladder Voiding via Pudendal Nerve Block
    KENNETH GUSTAFSON; Fiscal Year: 2009
    ..Although about 9% of Americans are veterans, they comprise over 17% of all individuals with spinal cord injuries in the United States...
  25. The Nerve Terminal as the Site of Action for Type-2 Alkenes
    RICHARD MICHAEL LOPACHIN; Fiscal Year: 2013
    ..The 1,3-dicarbonyl compounds, through their actions as surrogate nucleophiles, could prevent or minimize damage associated with environmentally acquired type-2 alkene toxicity. ..
  26. Molecular Pathogenesis of Skeletal Muscle Atrophy
    Christopher M Adams; Fiscal Year: 2013
    ..First, we found that ATF4 mRNA levels were increased in atrophied skeletal muscle from human subjects with spinal cord injuries. Second, we found that transfection of mouse skeletal muscle with plasmid DNA encoding mouse ATF4 induced ..
  27. Role of leucine zipper bearing kinase LZK in mammalian axon regeneration
    Meifan Chen; Fiscal Year: 2013
    ..consisting of the brain and spinal cord, to regenerate is a major obstacle to functional recovery from spinal cord injuries for which there is currently no effective treatment...
  28. Research Training in Rehabilitation for Brain Injury and Neurological Disability
    MICHAEL VAN DOREN JOHNSTON; Fiscal Year: 2013
    ..who will go on to make important contributions that advance the rehabilitation of patients with brain and spinal cord injuries and other neurological disabilities, and 2) equip these trainees with the skills needed to become ..
  29. Role of Protease Activated Receptors in Spinal Cord Injury and Repair
    Isobel A Scarisbrick; Fiscal Year: 2013
    ..abstract_text> ..
  30. Therapeutic Strategies for Spinal Cord Injury
    Radhika Vaishnav; Fiscal Year: 2009
    ..The objective of this project is to develop a combinatorial therapeutic strategy for the treatment of SCI in a rat model. The findings of this study will provide a foundation for the design of future translational studies in human SCI. ..
  31. In Vivo Control and Functional Visualization of Stem Cell-Driven CNS Regeneration
    Jin Hyung Lee; Fiscal Year: 2010
    ..for therapeutic development, the complex nature of the neural fabric underlying CNS diseases such as spinal cord injuries, Parkinson's disease, Alzheimer's disease, multiple sclerosis, and stroke, substantially negate ..
  32. Development of Biomaterials that Release Therapeutic Agents to Modulate Inflammat
    Ryan J Gilbert; Fiscal Year: 2010
    ..The research described in this proposal will determine if hydrogels loaded with glutathione or interleukin-10 are more effective at reducing secondary injury than injection of these agents in a rat spinal cord injury model. ..
  33. The Coordination of Netrin Signal Transduction
    Guofa Liu; Fiscal Year: 2011
    ..netrins will not only help us understand how the brain establishes its complex and precise wiring during development, but also provide a basis to design new strategies for injury-related diseases, such as stroke and spinal cord injuries.
  34. Neuroimaging based on DTI as a biomarker for spinal cord injury in children.
    Mary Jane Mulcahey; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Each year, an estimated 11,000 new spinal cord injuries occur in the United States...
  35. Role of Acrolein in Spinal Cord Injury
    Riyi Shi; Fiscal Year: 2013
    ..Such therapeutic strategies could benefit not only spinal cord injury, but also patients with other diseases associated with oxidative stress. ..
  36. Targeting Endogenous Inhibitors to Enhance Spinal Axon Regeneration After Injury
    Ronald L Schnaar; Fiscal Year: 2012
    ..approach is based on our recent discovery that delivery of the enzyme sialidase to the site of experimental spinal cord injuries results in significant enhancements in spinal axon outgrowth, locomotor recovery, and cardiovascular reflex ..
  37. Femtosecond laser axotomy for in vivo nerve regeneration studies in C elegans
    Adela Ben Yakar; Fiscal Year: 2010
    b>Spinal cord injuries with consequent paralysis affect more than 250,000 people in the US and several million worldwide. The biological causes that prevent axonal regeneration to occur in the central nervous system (CMS) are still elusive...
  38. Automated Assessment of Structural Changes &Functional Recovery Post Spinal Inju
    Baba C Vemuri; Fiscal Year: 2013
    ..Three severities of spinal cord injuries will be produced (light, mild and moderate contusions) based upon normed injury device parameters...
  39. LIM-HD/bHLH Combinatorial Code in Motoneurons
    Soo Kyung Lee; Fiscal Year: 2013
    ..These studies should also provide new tools for developing therapeutic strategies for the spinal cord injuries and diseases associated with impaired motor function, such as ALS (Lou Gehrig[unreadable]s disease), and ..
  40. Modulatory Axonal Guidance Cues
    Jonathan A Raper; Fiscal Year: 2012
    ..PROJECT NARRATIVE Spinal cord injuries leave approximately 10,000 people partially or fully paralyzed in the United States each year...
  41. The role of cAMP signaling in OSN axon convergence in the olfactory bulb
    PAULA MICHELLE HERON; Fiscal Year: 2012
    ..This understanding of endogenous neural replacement can only help advance the design of effective regenerative therapies for brain and spinal cord injuries.
  42. Muscle Plasticity, Fitness, and Health after Spinal Cord Injury
    Kevin K McCully; Fiscal Year: 2013
    ..Thus, this research has the potential to significantly benefit people with spinal cord injuries.
  43. Activity-dependent functional regeneration after SCI and OEC transplantation
    PATRICIA EMORY PHELPS; Fiscal Year: 2013
    ..Ultimately, such mechanisms may be among the best candidates to enhance the functional benefits derived from OEC transplantation in completely paralyzed SCI patients. ..
  44. The Neural Organization of Tool Use Actions in Humans
    Scott H Frey; Fiscal Year: 2010
    ..ADLs) involving tools and other manipulable objects, including: Cerebral Vascular Accidents (CVAs), spinal cord injuries, Multiple Sclerosis (MS), and Parkinson's Disease (PD)...
  45. The National Neurotrauma Society 30th Annual Conference (Phoenix July 22-25,2012)
    KEVIN KA WANG WANG; Fiscal Year: 2012
    ..In addition, approximately 12,000 new spinal cord injuries occur each year. The theme of this year's conference is "The Spectrum of Neurotrauma".
  46. CRCNS: Organization of the locomotor CPG in the rodent spinal cord
    Ilya A Rybak; Fiscal Year: 2013
    ..These CPGs survive upper spinal cord injuries, and are in principle capable of restoring locomotion after injury, as demonstrated in rodents and cats...
  47. Mechanisms Underlying Rhythm Generation in Identified Spinal Interneurons in Mice
    Lea Ziskind Conhaim; Fiscal Year: 2010
    ..spinal cord that is disconnected from descending voluntary control, will provide important insight into possible therapeutic strategies of activating undamaged neurons in rhythm generating networks of patients with spinal cord injuries.
  48. Anti-Inflammatory Microgel Coatings for Neural Electrodes
    Stacie M Gutowski; Fiscal Year: 2013
    ..Neuroprosthetic devices have the potential to restore functionality to patients with sensory loss, spinal cord injuries, and certain neurological diseases that affect brain function and signaling to the body...
  49. Spinal Control of Locomotion: Studies and Applications
    Ilya A Rybak; Fiscal Year: 2010
    ..pattern and control of locomotion and (2) to find optimal strategies for restoring locomotor function after spinal cord injuries. In this project, two comprehensive databases will be created based on experimental studies of fictive ..
  50. The 29th Annual National Neurotrauma Society Symposium
    Malcolm Ross Bullock; Fiscal Year: 2011
    ..Approximately 12,000 new spinal cord injuries occur each year...
  51. Motoneuron pool plasticity following spinal cord injury
    Thomas M Hamm; Fiscal Year: 2013
    ..In this project we will identify changes in the organization of motoneuron pools following incomplete spinal cord injuries, the effect of locomotor training on these changes, and the impact of these changes on motoneuron pool ..
  52. Brain-Robot Interfact: A Robust, High Performance Predictive Control Algorithm
    MST KAMRUNNAHAR; Fiscal Year: 2012
    ..It has implications that people with neurological disorders such as brain or spinal cord injuries will be better assisted through the development of smarter, more effective neural prosthetics.
  53. Mechanisms that Regulate Intracellular Transport
    Thomas S Hays; Fiscal Year: 2013
    ..Our work has important long-term implications for the understanding and treatment of spinal cord injuries, and the family of neurodegenerative diseases, including Amyotrophic lateral sclerosis, Huntington's ..
  54. Automatic Control of Standing Balance with Functional Neuromuscular Stimulation
    Ronald J Triolo; Fiscal Year: 2013
    ..control systems to restore standing function and enhance the postural stability of individuals paralyzed by spinal cord injuries (SCI)...
  55. NEUROMOLECULAR BASIS FOR PAIN IN SCI AND BURN INJURY
    Stephen Waxman; Fiscal Year: 2011
    ..to identify and characterize cellular and molecular mechanisms that contribute to pain following burn and spinal cord injuries, with the objective of delineating specific targets for more effective pain management...
  56. Molecular Determinants of Adult CNS Axonal Growth
    Stephen M Strittmatter; Fiscal Year: 2010
    ..This work is critical to optimize the opportunity for development of clinical methods to increase axonal growth and improve functional recovery from neurological damage. ..
  57. Spinal Cord-to-Computer Interface
    Mesut Sahin; Fiscal Year: 2013
    ..Each year about 15,000 spinal cord injuries occur in the US. Majority of these cases survive and depend on others for their basic needs...
  58. SENSORY AND MOTOR INTEGRATION IN THE SPINAL CORD
    PAUL S STEIN; Fiscal Year: 2010
    ..There is considerable similarity in the organization of spinal cord in all vertebrates, including humans. Our findings of CPG organization will be of interest to those developing new therapies for spinal-injured humans. ..
  59. Regenerative and Degenerative Responses to Axonal Injury
    Catherine A Collins; Fiscal Year: 2013
    ..The findings from this work will be important both for treatment of spinal cord injuries and also for understanding mechanisms of neurodegenerative disorders.
  60. Visual Motor Transformation in Cortex
    Lawrence H Snyder; Fiscal Year: 2012
    ..how the brain generates and represents plans for movement is also critical to the development of promising neuroprosthetics for patients with amputations, spinal cord injuries, and disorders such as amyotrophic lateral sclerosis.
  61. Control of Locomotor Activity by Identified Premotor Spinal Interneurons
    Mark A Masino; Fiscal Year: 2013
    ..locomotion, which can be used to inform clinical and procedural strategies to treat individuals with spinal cord injuries. PUBLIC HEALTH RELEVANCE: In vertebrates, the neural network that drives locomotion is composed of a set of ..
  62. Repair of Brachial Sensory Root Injuries in the Spinal Cord
    Eric Frank; Fiscal Year: 2010
    ..The goal of these experiments is to determine if artemin is sufficiently effective to warrant study for the repair of brachial root injuries in humans. ..
  63. 31st Annual National Neurotrauma Society(NNS)Symposium
    Claudia S Robertson; Fiscal Year: 2013
    ..Highlights of the program include sessions on combination therapy for neurotrauma;combined brain and spinal cord injuries;mild TBI updates including new treatment strategies for mild TBI and post-trauma headaches;SCI updates on ..
  64. Novel Ex Vivo Gene Therapy for Spinal Cord Injury
    Alpa Trivedi; Fiscal Year: 2004
    There are approximately 10,000 traumatic spinal cord injuries in the United States each year. The average age of injury is 31 years. The majority (90%) of individuals survive and live near-normal life spans...
  65. Neuroprotective Drugs for Spinal Cord Injury
    JEAN WRATHALL; Fiscal Year: 2001
    ..PROPOSED COMMERCIAL APPLICATION: On average, 11,000 traumatic spinal cord injuries (SCI) are reported every year in the United States...
  66. REGENERATION IN THE SPINAL CORD-ROLE OF NEUROFILAMENT
    MICHAEL SELZER; Fiscal Year: 2003
    ..4) The in situ studies will be extended to animals that either underexpress or overexpress NF-180, as described for Specific Aims 1 and 2. ..
  67. Interneuronal mechanisms for the control of walking
    Jianguo Cheng; Fiscal Year: 2009
    Paraplegic patients dream to be able to walk again after spinal cord injuries. A practical issue concerns the feasibility to reactivate the spared spinal neural circuitry to control some of the lost locomotor functions...
  68. Molecular Mechanisms of PDE5 Regulation
    Jackie Corbin; Fiscal Year: 2005
    ..which is used in treatment of male erectile dysfunction associated with diabetes, aging, spinal cord injuries and other pathologies...
  69. Spinal Cord Stimulation to Restore Cough In Humans
    Anthony DiMarco; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Patients with cervical and thoracic spinal cord injuries have paralysis of a major portion of their expiratory muscles and therefore, lack a normal cough mechanism...
  70. GUIDANCE MOLECULES IN SPINAL CORD REGENERATION
    MICHAEL SELZER; Fiscal Year: 2009
    ....
  71. PAIN MANAGEMENT IN PERSONS WITH DISABILITIES
    Barbara de Lateur; Fiscal Year: 2000
    ..project is the development and evaluation of treatments for chronic pain in persons with amputations and spinal cord injuries (SCI)...
  72. BODY COMPOSITION AND NUTRITION IN SPINAL CORD INJURY
    PAUL SCHLOERB; Fiscal Year: 1991
    ..From all of these data, optimum protein-calorie nutritional support will be defined...
  73. Carbon Nanotube Fibers as Implantable Neural Electrodes
    Douglas Adamson; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Sensory and stimulatory prosthetic devices to treat spinal cord injuries and other nervous system diseases require implantation of electrically conductive interfaces between neural tissues and ..
  74. REDUCING SPINAL CORD INJURY WITH RETROGRADE PERFUSION
    John Kern; Fiscal Year: 2004
    DESCRIPTION (Verbatim from Applicant's Abstract): Many people suffer traumatic spinal cord injuries in the United States every year...
  75. Developing a pocket neuromuscular evaluator
    Li Qun Zhang; Fiscal Year: 2010
    ..widely used to evaluate neurological state and diagnose various neurological disorders including stroke, spinal cord injuries, multiple sclerosis, and cerebral palsy...