craniocerebral trauma

Summary

Summary: Traumatic injuries involving the cranium and intracranial structures (i.e., BRAIN; CRANIAL NERVES; MENINGES; and other structures). Injuries may be classified by whether or not the skull is penetrated (i.e., penetrating vs. nonpenetrating) or whether there is an associated hemorrhage.

Top Publications

  1. ncbi Indications for computed tomography in patients with minor head injury
    M J Haydel
    Section of Emergency Medicine, Louisiana State University Health Science Center at New Orleans, USA
    N Engl J Med 343:100-5. 2000
  2. ncbi S100-B protein as a screening tool for the early assessment of minor head injury
    Drissa Zongo
    Service des urgences adultes, Hopital Pellegrin, Bordeaux, France
    Ann Emerg Med 59:209-18. 2012
  3. ncbi Concussion in professional football: reconstruction of game impacts and injuries
    Elliot J Pellman
    ProHEALTH Care Associates, LLP, Lake Success, New York, USA
    Neurosurgery 53:799-812; discussion 812-4. 2003
  4. ncbi The Canadian CT Head Rule for patients with minor head injury
    I G Stiell
    Divisions of Emergency Medicine, University of British Columbia, Vancouver, Canada
    Lancet 357:1391-6. 2001
  5. ncbi Publication bias and time-trend bias in meta-analysis of bicycle helmet efficacy: a re-analysis of Attewell, Glase and McFadden, 2001
    Rune Elvik
    Institute of Transport Economics, Gaustadalleen 21, NO 0349 Oslo, Norway
    Accid Anal Prev 43:1245-51. 2011
  6. ncbi The potential of melatonin in reducing morbidity-mortality after craniocerebral trauma
    M D Maldonado
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA, and Center for Rehabilitation and Traumatology of the Hospital University Virgen del Rocio, Seville, Spain
    J Pineal Res 42:1-11. 2007
  7. ncbi Comparison of the Canadian CT Head Rule and the New Orleans Criteria in patients with minor head injury
    Ian G Stiell
    Department of Emergency Medicine, University of Ottawa, Ottawa, Ontario, Canada
    JAMA 294:1511-8. 2005
  8. ncbi Neurochemical aftermath of amateur boxing
    Henrik Zetterberg
    Department of Experimental Neuroscience, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Arch Neurol 63:1277-80. 2006
  9. pmc Implementation of the Canadian C-Spine Rule: prospective 12 centre cluster randomised trial
    Ian G Stiell
    Department of Emergency Medicine, University of Ottawa, Canada
    BMJ 339:b4146. 2009
  10. ncbi Impact of mandatory helmet legislation on bicycle-related head injuries in children: a population-based study
    Alison K Macpherson
    Division of Paediatric Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatrics 110:e60. 2002

Detail Information

Publications355 found, 100 shown here

  1. ncbi Indications for computed tomography in patients with minor head injury
    M J Haydel
    Section of Emergency Medicine, Louisiana State University Health Science Center at New Orleans, USA
    N Engl J Med 343:100-5. 2000
    ..We performed a study to develop and validate a set of clinical criteria that could be used to identify patients with minor head injury who do not need to undergo CT...
  2. ncbi S100-B protein as a screening tool for the early assessment of minor head injury
    Drissa Zongo
    Service des urgences adultes, Hopital Pellegrin, Bordeaux, France
    Ann Emerg Med 59:209-18. 2012
    ..We evaluate S100-B protein measurement as a screening tool in a large population of patients with minor head injury...
  3. ncbi Concussion in professional football: reconstruction of game impacts and injuries
    Elliot J Pellman
    ProHEALTH Care Associates, LLP, Lake Success, New York, USA
    Neurosurgery 53:799-812; discussion 812-4. 2003
    ..Concussion in professional football was studied with respect to impact types and injury biomechanics. A combination of video surveillance and laboratory reconstruction of game impacts was used to evaluate concussion biomechanics...
  4. ncbi The Canadian CT Head Rule for patients with minor head injury
    I G Stiell
    Divisions of Emergency Medicine, University of British Columbia, Vancouver, Canada
    Lancet 357:1391-6. 2001
    ..There is much controversy about the use of computed tomography (CT) for patients with minor head injury. We aimed to develop a highly sensitive clinical decision rule for use of CT in patients with minor head injuries...
  5. ncbi Publication bias and time-trend bias in meta-analysis of bicycle helmet efficacy: a re-analysis of Attewell, Glase and McFadden, 2001
    Rune Elvik
    Institute of Transport Economics, Gaustadalleen 21, NO 0349 Oslo, Norway
    Accid Anal Prev 43:1245-51. 2011
    ..The re-analysis shows smaller safety benefits associated with the use of bicycle helmets than the original study...
  6. ncbi The potential of melatonin in reducing morbidity-mortality after craniocerebral trauma
    M D Maldonado
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA, and Center for Rehabilitation and Traumatology of the Hospital University Virgen del Rocio, Seville, Spain
    J Pineal Res 42:1-11. 2007
    b>Craniocerebral trauma (CCT) is the most frequent cause of morbidity-mortality as a result of an accident...
  7. ncbi Comparison of the Canadian CT Head Rule and the New Orleans Criteria in patients with minor head injury
    Ian G Stiell
    Department of Emergency Medicine, University of Ottawa, Ottawa, Ontario, Canada
    JAMA 294:1511-8. 2005
    ..However, uncertainty about the clinical performance of these rules exists...
  8. ncbi Neurochemical aftermath of amateur boxing
    Henrik Zetterberg
    Department of Experimental Neuroscience, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Arch Neurol 63:1277-80. 2006
    ..Little solid information is available on the possible risks for neuronal injury in amateur boxing...
  9. pmc Implementation of the Canadian C-Spine Rule: prospective 12 centre cluster randomised trial
    Ian G Stiell
    Department of Emergency Medicine, University of Ottawa, Canada
    BMJ 339:b4146. 2009
    ..To evaluate the effectiveness of an active strategy to implement the validated Canadian C-Spine Rule into multiple emergency departments...
  10. ncbi Impact of mandatory helmet legislation on bicycle-related head injuries in children: a population-based study
    Alison K Macpherson
    Division of Paediatric Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatrics 110:e60. 2002
    ..In Canada, 4 provinces have such legislation. The objective of this study was to measure the impact of helmet legislation on bicycle-related head injuries in Canadian children...
  11. ncbi Can the initial history predict whether a child with a head injury has been abused?
    Joeli Hettler
    Division of Emergency Medicine, Children s Hospital, Boston, Harvard Medical School, Boston, MA 02115, USA
    Pediatrics 111:602-7. 2003
    ..The objective of this study was to determine the diagnostic utility of certain historical features for identifying cases of abusive head trauma...
  12. ncbi Incidence and demography of non-accidental head injury in southeast Scotland from a national database
    Robert A Minns
    Department of Child Life and Health, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    Am J Prev Med 34:S126-33. 2008
    ....
  13. ncbi The effects of provincial bicycle helmet legislation on helmet use and bicycle ridership in Canada
    Jessica Dennis
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Inj Prev 16:219-24. 2010
    ..The objectives of this study were to determine the association between the comprehensiveness of helmet legislation and both helmet use and bicycle ridership...
  14. ncbi Scandinavian guidelines for initial management of minimal, mild, and moderate head injuries. The Scandinavian Neurotrauma Committee
    T Ingebrigtsen
    Norwegian Neurosurgical Society
    J Trauma 48:760-6. 2000
    ..The Scandinavian Neurotrauma Committee was initiated by the Scandinavian Neurosurgical Society to develop evidence-based guidelines for improved care of neurotrauma patients...
  15. ncbi Diagnostic management strategies for adults and children with minor head injury: a systematic review and an economic evaluation
    A Pandor
    School of Health and Related Research ScHARR, University of Sheffield, Sheffield, UK
    Health Technol Assess 15:1-202. 2011
    ..Selective use of CT investigations helps minimise unnecessary radiation exposure and resource use, but can lead to missed opportunities to provide early treatment for ICI...
  16. ncbi Bicycle helmet efficacy: a meta-analysis
    R G Attewell
    Covance Pty Ltd, Ainslie, ACT, Australia
    Accid Anal Prev 33:345-52. 2001
    ..Despite this, the use of helmets is sub-optimal. Helmet use for all riders should be further encouraged to the extent that it is uniformly accepted and analogous to the use of seat belts by motor vehicle occupants...
  17. ncbi Disaster epidemiology and medical response in the Chi-Chi earthquake in Taiwan
    N J Liang
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Ann Emerg Med 38:549-55. 2001
    ..Epidemiologic analysis can guide disaster response and preparation...
  18. ncbi Pattern of maxillofacial and associated injuries in road traffic accidents
    M K Akama
    Department of Oral and Maxillofacial Surgery, School of Dental Sciences, University of Nairobi, P O Box 19676 00202, Nairobi, Kenya
    East Afr Med J 84:287-95. 2007
    ..In an attempt to reduce RTAs, the government of Kenya has enacted a legislation requiring mandatory fitting of speed governors and safety belts by passenger service vehicles...
  19. ncbi Effects of head and extracranial injuries on serum protein S100B levels in trauma patients
    Olli Savola
    Department of Neurology, Oulu University Hospital, Oulu, Finland
    J Trauma 56:1229-34; discussion 1234. 2004
    ..Serum protein S100B determinations have been recently suggested as markers of traumatic brain injury. However, little is known about the effects of extracranial injuries on S100B levels in trauma patients...
  20. pmc A prospective cluster-randomized trial to implement the Canadian CT Head Rule in emergency departments
    Ian G Stiell
    Department of Emergency Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ont
    CMAJ 182:1527-32. 2010
    ..We sought to evaluate the effectiveness of implementing this validated decision rule at multiple emergency departments...
  21. pmc Impact of early intervention on outcome following mild head injury in adults
    J Ponsford
    Monash Epworth Rehabilitation Research Centre, Epworth Hospital, Richmond, Victoria, Australia
    J Neurol Neurosurg Psychiatry 73:330-2. 2002
    ..The impact of mild head injury is variable and determinants of outcome remain poorly understood. Results of previous intervention studies have been mixed...
  22. ncbi Indications for computed tomography in patients with mild head injury
    Kenichiro Ono
    Department of Neurosurgery, Japan Self Defense Forces Central Hospital, Tokyo
    Neurol Med Chir (Tokyo) 47:291-7; discussion 297-8. 2007
    ..These indications for CT including JCS may be useful in the management of patients with mild head injury...
  23. ncbi Serum S-100B concentration provides additional information fot the indication of computed tomography in patients after minor head injury: a prospective multicenter study
    Peter Biberthaler
    Chirurgische Klinik und Poliklinik Innenstadt, Ludwig Maximilians Universitat Munchen, Nussbaumstrasse 20, 80336 Munchen, Germany
    Shock 25:446-53. 2006
    ..A prospective study of the clinical value of S-100B measurement in such patients is now under way...
  24. ncbi Reducing regional inequality in mortality from road traffic injuries through enforcement of the mandatory motorcycle helmet law in Taiwan
    Tsung Hsueh Lu
    NCKU Research Center for Health Data and Institute of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Inj Prev 18:150-7. 2012
    ..This study was conducted to examine whether passage of the mandatory motorcycle helmet law in 1997 reduced the regional inequality in mortality from road traffic injuries (RTIs) across 22 cities/counties in Taiwan...
  25. ncbi Adult respiratory distress syndrome: a complication of induced hypertension after severe head injury
    C F Contant
    Department of Neurosurgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosurg 95:560-8. 2001
    ....
  26. ncbi The impact of compulsory cycle helmet legislation on cyclist head injuries in New South Wales, Australia
    Scott R Walter
    NSW Injury Risk Management Research Centre, University of New South Wales, Sydney, Australia
    Accid Anal Prev 43:2064-71. 2011
    ..Despite numerous data limitations, we identified evidence of a positive effect of compulsory cycle helmet legislation on cyclist head injuries at a population level such that repealing the law cannot be justified...
  27. pmc Diagnostic criteria and the use of ICD-10 codes to define and classify minor head injury
    J Bellner
    Department of Neurosurgery, Lund University Hospital, Lund, Sweden
    J Neurol Neurosurg Psychiatry 74:351-2. 2003
    ..Epidemiological research on the incidence of traumatic head injuries relies on the correct definition and classification of the injury...
  28. ncbi Post-traumatic cerebral infarction. Neuroimaging findings, etiology and outcome
    A Server
    Department of Neuroradiology, Division of Radiology, , Oslo, Norway
    Acta Radiol 42:254-60. 2001
    ..The overall death rate was 43.8% and this result suggests that PTCI is an indication of a poor clinical outcome, especially among patients with associated subdural hematoma, brain swelling/edema and tSAH...
  29. ncbi The cost-effectiveness of diagnostic management strategies for adults with minor head injury
    M W Holmes
    School of Health and Related Research, The University of Sheffield, United Kingdom
    Injury 43:1423-31. 2012
    ..To estimate the cost-effectiveness of diagnostic management strategies for adults with minor head injury...
  30. pmc Head impact exposure in youth football
    Ray W Daniel
    Center for Injury Biomechanics, Virginia Tech Wake Forest University, 440 ICTAS Building, Stanger St, Blacksburg, VA 24061, USA
    Ann Biomed Eng 40:976-81. 2012
    ..In order to minimize these most severe head impacts, youth football practices should be modified to eliminate high impact drills that do not replicate the game situations...
  31. ncbi Bicycle helmet wearing and the risk of head, face, and neck injury: a French case--control study based on a road trauma registry
    Emmanuelle Amoros
    Transport, Occupational and Environmental Epidemiology Research and Surveillance Unit UMRESTTE, French Institute of Science and Technology for Transport, Development and Networks IFSTTAR, Lyon Bron, France
    Inj Prev 18:27-32. 2012
    ..Previous case-control studies on bicycle helmet efficacy are mostly Anglo-Saxon, and based on data from the early 1990s when hard-shell helmets were common...
  32. ncbi Bicycle safety helmet legislation and bicycle-related non-fatal injuries in California
    Brian Ho Yin Lee
    Department of Urban Design and Planning, College of Architecture and Urban Planning, University of Washington, 3949 15th Avenue N E, 410 Gould Hall, Box 355740, Seattle, WA 98195 5740, USA
    Accid Anal Prev 37:93-102. 2005
    ....
  33. ncbi Can social psychological models be used to promote bicycle helmet use among teenagers? A comparison of the Health Belief Model, Theory of Planned Behavior and the Locus of Control
    Timo Lajunen
    Department of Psychology, Middle East Technical University, ODTU 06531, Ankara, Turkey
    J Safety Res 35:115-23. 2004
    ..Attitudes, personality and behavior. Open University Press, Milton Keynes) and Locus of Control model (LC; Psychological Monographs, (1966) (80) in understanding the intention to use bicycle helmet use among bicycle helmet owners...
  34. ncbi Emergency head injury imaging: implementing NICE 2007 in a tertiary neurosciences centre and a busy district general hospital
    J S Mooney
    Salford Royal Foundation NHS Trust, Emergency Department, Salford, UK
    Emerg Med J 28:778-82. 2011
    ..Head injuries are a common emergency department (ED) presentation. The National Institute for Health and Clinical Excellence (NICE) updated its guidance in September 2007 regarding imaging required for patients with head injuries...
  35. ncbi Barriers to bicycle helmet use among Dutch paediatricians
    E Villamor
    Department of Pediatrics, Research Institute Growth and Development, Maastricht University Medical Centre, Maastricht, The Netherlands
    Child Care Health Dev 34:743-7. 2008
    ..We aimed to determine why Dutch paediatricians do or do not wear helmets while bicycling and whether their personal behaviour is influencing their position about the promotion of helmet use...
  36. ncbi External validation of the Canadian CT Head Rule and the New Orleans Criteria for CT scanning in patients with minor head injury
    Marion Smits
    Department of Radiology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
    JAMA 294:1519-25. 2005
    ....
  37. ncbi S100B serum level predicts computed tomography findings after minor head injury
    Kay Müller
    Department of Neurosurgery, University Hospital of North Norway, Tromsø, Norway
    J Trauma 62:1452-6. 2007
    ..The present multicenter study was performed to investigate whether determination of protein S100B in serum could contribute to the selection of patients for CT scanning...
  38. ncbi Consequences of head size following trauma to the human head
    Svein Kleiven
    Department of Aeronautics, Royal Institute of Technology, Teknikringen, 8 100 44 Stockholm, Sweden
    J Biomech 35:153-60. 2002
    ..The conclusion is that the size dependence of the intracranial stresses associated with injury, is not predicted by the HIC. It is suggested that variations in head size should be considered when developing new head injury criteria...
  39. pmc Environmental risk factors for Parkinson's disease and parkinsonism: the Geoparkinson study
    F D Dick
    Dr F Dick, Department of Environmental and Occupational Medicine, Aberdeen University Medical School, Foresterhill, Aberdeen AB25 2ZP, UK
    Occup Environ Med 64:666-72. 2007
    ..To investigate the associations between Parkinson's disease and other degenerative parkinsonian syndromes and environmental factors in five European countries...
  40. pmc Subdural haematoma and effusion in infancy: an epidemiological study
    C Hobbs
    Community Paediatrics, St James s University Hospital, Leeds, UK
    Arch Dis Child 90:952-5. 2005
    ..To determine incidence, aetiology, and clinical features of subdural haematoma and effusion (SDH/E) in infancy throughout the British Isles...
  41. ncbi Neck injuries in young pediatric homicide victims
    Laura K Brennan
    Division of General Pediatrics, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    J Neurosurg Pediatr 3:232-9. 2009
    ....
  42. ncbi Shaken baby syndrome in Switzerland: results of a prospective follow-up study, 2002-2007
    Manuela Fanconi
    Child Protection Group, University Children s Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland
    Eur J Pediatr 169:1023-8. 2010
    ..Demographic characteristics and outcomes of Swiss patients were comparable to published studies...
  43. ncbi A review of risk factors and patterns of motorcycle injuries
    Mau Roung Lin
    Institute of Injury Prevention and Control, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan, ROC
    Accid Anal Prev 41:710-22. 2009
    ..Features of motorcycle use and potentially effective prevention programs for motorcycle crash injuries in developing countries are discussed. Finally, recommendations for future motorcycle-injury research are made...
  44. ncbi Measuring acceptability of clinical decision rules: validation of the Ottawa acceptability of decision rules instrument (OADRI) in four countries
    Jamie C Brehaut
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, ON, Canada
    Med Decis Making 30:398-408. 2010
    ..No existing instrument measures the acceptability of a rule. The current study validated such an instrument...
  45. ncbi Analysis of missed cases of abusive head trauma
    C Jenny
    Department of Pediatrics, Brown University School of Medicine, Providence, RI, USA
    JAMA 281:621-6. 1999
    ..Abusive head trauma (AHT) is a dangerous form of child abuse that can be difficult to diagnose in young children...
  46. ncbi Minor head injury: guidelines for the use of CT--a multicenter validation study
    Marion Smits
    Department of Radiology, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Radiology 245:831-8. 2007
    ..To prospectively and externally validate published national and international guidelines for the indications of computed tomography (CT) in patients with a minor head injury...
  47. ncbi Subsequent development of thrombocytopenia and coagulopathy in moderate and severe head injury: support for serial laboratory examination
    Matthew M Carrick
    Michel E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA
    J Trauma 58:725-9; discussion 729-30. 2005
    ..This study assessed the development of thrombocytopenia and coagulopathy at admission and within the subsequent 72 hours after TBI...
  48. ncbi Raised serum S100B levels after acute bone fractures without cerebral injury
    Johan Undén
    Department of Neurosurgery, Lund University Hospital, Lund, Sweden
    J Trauma 58:59-61. 2005
    ..However, the cerebral specificity of S100B has been questioned. This study aims to show serum S100B levels after uncomplicated bone fractures in patients without current or prior neurologic diseases...
  49. ncbi Coagulopathy as a parameter to predict the outcome in head injury patients--analysis of 61 cases
    Jinn Rung Kuo
    Department of Neurosurgery, Chi Mei Medical Center, Yung Kang City, Tainan, Taiwan
    J Clin Neurosci 11:710-4. 2004
    ..We conclude that: (1) Coagulation state in head injury patients within 24 h after injury is of value in determining the outcome. (2) Coagulopathy score > or = 4 is a good predictor to evaluate mortality rate of head injury patients...
  50. ncbi Bicycle-related injuries among children and adolescents in the United States
    Tracy J Mehan
    Center for Injury Research and Policy, The Research Institute at Nationwide Children s Hospital, The Ohio State University, Columbus, OH, 43205, USA
    Clin Pediatr (Phila) 48:166-73. 2009
    ..77) times more likely to have their injuries result in death. The large number of annual bicycle related-injuries is evidence that prevention of these injuries should remain an important area of bicycle safety research and practice...
  51. ncbi Epidural hematoma in infants: a different entity?
    L Beni-Adani
    Department of Neurosurgery, Hadassah University Hospital, Ein Karem, Jerusalem, Israel
    J Trauma 46:306-11. 1999
    ..Because there are no optimal prognostic tools or clear guidelines to perform computed tomography in this unique population, a new approach of neurotrauma scoring is suggested...
  52. ncbi Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study
    Nathan Kuppermann
    Department of Emergency Medicine, University of California, Davis School of Medicine, Davis, CA, USA
    Lancet 374:1160-70. 2009
    ..CT imaging of head-injured children has risks of radiation-induced malignancy. Our aim was to identify children at very low risk of clinically-important traumatic brain injuries (ciTBI) for whom CT might be unnecessary...
  53. pmc Effect of alcohol on Glasgow Coma Scale in head-injured patients
    Lance Stuke
    Department of Surgery, Division of Burns, Trauma and Surgical Critical Care, University of Texas Southwestern Medical School, Dallas, TX 75390 9158, USA
    Ann Surg 245:651-5. 2007
    ..The purpose of this study was to test the hypothesis that the presence of blood alcohol has a clinically significant impact on GCS in TBI patients...
  54. pmc Severe traumatic head injury affects systemic cytokine expression
    Damien J LaPar
    Division of Trauma and Surgical Critical Care, Department of Surgery, University of Virginia, Charlottesville, VA 22903, USA
    J Am Coll Surg 214:478-86; discussion 486-8. 2012
    ..This study aimed to characterize systemic cytokine profiles among traumatically injured patients to assess the effect of traumatic head injury on the systemic inflammatory response...
  55. ncbi Secondary intracranial hemorrhage after mild head injury in patients with low-dose acetylsalicylate acid prophylaxis
    Mark Tauber
    Department of Traumatology and Sports Injuries, University Hospital of Salzburg, Salzburg, Austria
    J Trauma 67:521-5; discussion 525. 2009
    ..In the literature, there is no evidence concerning the incidence of secondary intracranial hemorrhagic events (SIHE) in patients with LDA prophylaxis that had negative primary computed tomography (CT)-scan of the head...
  56. ncbi Intractable epilepsy and craniocerebral trauma: analysis of 163 patients with blunt and penetrating head injuries sustained in war
    Hadi Kazemi
    Shefa Neuroscience Research Center, Tehran, Iran
    Injury 43:2132-5. 2012
    ..Patients with military brain injury carry a high risk of intractable post-traumatic epilepsy decades after their injury, and thus require a long-term medical follow-up...
  57. ncbi Validation of a wireless head acceleration measurement system for use in soccer play
    ERIN HANLON
    Bioengineering Center, College of Engineering, Wayne State University, Detroit, MI, USA
    J Appl Biomech 26:424-31. 2010
    ..96 ± 0.02 for head to head forehead impacts. The systems showed a strong relationship when comparing RMS error, linear head acceleration, angular head acceleration, and the cross correlation values...
  58. ncbi Mild head injury - mortality and complication rate: meta-analysis of findings in a systematic literature review
    J L Af Geijerstam
    The Swedish Council on Technology Assessment in Health Care SBU, Stockholm, Sweden
    Acta Neurochir (Wien) 145:843-50; discussion 850. 2003
    ..These have not been reliably summarised. The study aims to estimate as accurately as possible the mortality, the complication rates, and the frequency of pathological findings on CT in patients with mild head injury...
  59. ncbi A nationwide review of the associations among cervical spine injuries, head injuries, and facial fractures
    Ryan Patrick Mulligan
    Divisions of Neurosurgery and Plastic Surgery, Texas A and M Health Science Center and Scott and White, Temple, Texas, USA
    J Trauma 68:587-92. 2010
    ..The purpose of this study was to review the incidence of facial fractures, c-spine injuries, and head injuries at trauma centers across the United States...
  60. ncbi Pediatric crushing head injury: biomechanics and clinical features of an uncommon type of craniocerebral trauma
    Antonio López López-Guerrero
    Unit of Pediatric Neurosurgery and Regional Service of Neurosurgery, Virgen de Arrixaca University Hospital, 30120 El Palmar, Murcia, Spain
    Childs Nerv Syst 28:2033-40. 2012
    ..However, a special type of head injury occurs when the children sustain a traumatism whose main component is a static load in relation to a crushing mechanism with the head relatively immobile...
  61. ncbi Predicting intracranial lesions by antiplatelet agents in subjects with mild head injury
    Andrea Fabbri
    Dipartimento dell Emergenza, Presidio Ospedaliero Morgagni Pierantoni, Azienda USL Forlì, Via Forlanini 34, I 47100 Forlì, Italy
    J Neurol Neurosurg Psychiatry 81:1275-9. 2010
    ..The effect of pre-injury antiplatelet treatment in the risk of intracranial lesions in subjects after mild head injury (Glasgow Coma Scale (GCS) 14-15) is uncertain...
  62. pmc Emotional and cognitive consequences of head injury in relation to the glasgow outcome scale
    J T Wilson
    Department of Psychology, University of Stirling, Stirling FK9 4LA, UK
    J Neurol Neurosurg Psychiatry 69:204-9. 2000
    ..The aims of the study were to investigate aspects of the validity of structured interviews for the GOS, and address the issue of the relation between the GOS and subjective reports of health outcome...
  63. ncbi Mortality prediction of head Abbreviated Injury Score and Glasgow Coma Scale: analysis of 7,764 head injuries
    Demetrios Demetriades
    Division of Trauma and SICU, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Am Coll Surg 199:216-22. 2004
    ..We assessed the prognostic value and limitations of Glasgow Coma Scale (GCS) and head Abbreviated Injury Score (AIS) and correlated head AIS with GCS...
  64. ncbi The Canadian CT Head Rule Study for patients with minor head injury: rationale, objectives, and methodology for phase I (derivation)
    I G Stiell
    Ottawa Hospital Research Institute, 1053 Carling Avenue, Ottawa, Ontario, Canada K1Y 4E9
    Ann Emerg Med 38:160-9. 2001
    ..The Canadian CT Head Rule Study for patients with minor head injury: rationale, objectives, and methodology for phase I (derivation). Ann Emerg Med. August 2001;38:160-169.]..
  65. ncbi Trends in helmet use and head injuries in San Diego County: the effect of bicycle helmet legislation
    Ming Ji
    Division of Epidemiology and Biostatistics, Graduate School of Public Health, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 4162, USA
    Accid Anal Prev 38:128-34. 2006
    ..Probably due to several of its limitations, the current study did not confirm that helmet legislation alone significantly reduced head injury rates in San Diego County during the study period...
  66. ncbi Effect of mouthguards on head responses and mandible forces in football helmet impacts
    David C Viano
    ProBiomechanics LLC, 265 Warrington Rd, Bloomfield Hills, MI 48304 2952, USA
    Ann Biomed Eng 40:47-69. 2012
    ..8-63.9%. Mouthguards tested in this study with the Hybrid III articulating mandible lowered forces on the dentition and TMJ, but generally did not influence HIC or concussion risks...
  67. ncbi Intracranial effects of endotracheal suctioning in the acute phase of head injury
    Marco Gemma
    University of Milano, Institute of Anesthesiology and Intensive Care, Neurointensive Care Unit, IRCCS San Raffaele Hospital, Milano, Italy
    J Neurosurg Anesthesiol 14:50-4. 2002
    ..In the case of patients with head injuries who coughed or moved during endotracheal suctioning, we strongly suggest deepening the level of sedation before completing the procedure to reduce the risk of adverse effects...
  68. ncbi [Influence of the respiratory physiotherapy on intracranial pressure in severe head trauma patients]
    Rosana A Thiesen
    Unidade de Terapia Intensiva, Hospital das Clinicas, Universidade Estadual de Campinas, Campinas, SP, Brazil
    Arq Neuropsiquiatr 63:110-3. 2005
    ..To evaluate influence of the respiratory physiotherapy on intracranial pressure (ICP) in patients with severe head trauma...
  69. ncbi Performance of the Canadian CT Head Rule and the New Orleans Criteria for predicting any traumatic intracranial injury on computed tomography in a United States Level I trauma center
    Linda Papa
    Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, FL, USA
    Acad Emerg Med 19:2-10. 2012
    ..Additionally, the performance of the CCHR was assessed in a larger cohort of those presenting with GCS of 13 to 15...
  70. ncbi Endotracheal lidocaine in preventing endotracheal suctioning-induced changes in cerebral hemodynamics in patients with severe head trauma
    Federico Bilotta
    Department of Anesthesiology, Intensive Care and Pain Medicine, University of Rome La Sapienza, Viale Somalia, 81, Rome, 00199, Italy
    Neurocrit Care 8:241-6. 2008
    ....
  71. ncbi Abusive head trauma during a time of increased unemployment: a multicenter analysis
    Rachel P Berger
    Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania 15224, USA
    Pediatrics 128:637-43. 2011
    ..To evaluate the rate of abusive head trauma (AHT) in 3 regions of the United States before and during an economic recession and assess whether there is a relationship between the rate of AHT and county-level unemployment rates...
  72. ncbi Posttraumatic cerebral infarction in patients with moderate or severe head trauma
    R Marino
    Institute of Anesthesiology Intensive Care, University of Brescia, Brescia, Italy
    Neurology 67:1165-71. 2006
    ..To evaluate the frequency, types, and location of posttraumatic cerebral infarction, to assess if secondary cerebral insults were associated with cerebral infarction, and to determine if cerebral infarction affected patients' outcome...
  73. ncbi Motor vehicle injuries in childhood: a hospital-based study in Saudi Arabia
    Stanley J Crankson
    Division of Pediatric Surgery, Department of Surgery, King Abdulaziz Medical City Riyadh, King Fahad National Guard Hospital, P O Box 22490, Riyadh 11426, Kingdom of Saudi Arabia
    Pediatr Surg Int 22:641-5. 2006
    ..Head trauma is the most common cause of morbidity and mortality. This study suggests that nationwide programs should target the use of seatbelts and helmets, and dangerous driving practices...
  74. pmc Effectiveness of bicycle helmet legislation to increase helmet use: a systematic review
    M Karkhaneh
    Department of Public Health Sciences, University of Alberta, Edmonton, Canada
    Inj Prev 12:76-82. 2006
    ..Helmet legislation has been proposed as a method to increase helmet wearing; while this social intervention is thought to be effective, no systematic review has been performed...
  75. ncbi Estimating the probability of abusive head trauma: a pooled analysis
    Sabine Ann Maguire
    Department of Child Health, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Pediatrics 128:e550-64. 2011
    ..To determine which combinations of clinical features assist in distinguishing abusive head trauma (AHT) from nonabusive head trauma...
  76. ncbi Developing a decision instrument to guide computed tomographic imaging of blunt head injury patients
    William R Mower
    UCLA Emergency Medicine Center, UCLA School of Medicine, Los Angeles, CA 90024, USA
    J Trauma 59:954-9. 2005
    ..Clinical characteristics may be able reliably identify patients who do not have intracranial injuries and consequently, do no require imaging...
  77. ncbi Chronic tinnitus resulting from head or neck injuries
    Robert L Folmer
    Department of Otolaryngology, Oregon Hearing Research Center, Oregon Health Science University Tinnitus Clinic, Portland, 97239, USA
    Laryngoscope 113:821-7. 2003
    ....
  78. pmc Effect of legislation on the use of bicycle helmets
    John C LeBlanc
    Department of Pediatrics, Dalhousie University, Halifax, NS
    CMAJ 166:592-5. 2002
    ..We measured compliance before, during and after 1997, when legislation making the use of helmets mandatory for cyclists was enacted in Nova Scotia...
  79. pmc Arguments against helmet legislation are flawed
    Brent Hagel
    Montreal Children s Hospital Research Institute, Montreal, Canada
    BMJ 332:725-6. 2006
  80. ncbi Management of severe head injury: institutional variations in care and effect on outcome
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle, WA, USA
    Crit Care Med 30:1870-6. 2002
    ....
  81. pmc Mild head injury: reliability of early computed tomographic findings in triage for admission
    J L Af Geijerstam
    The Swedish Council on Technology Assessment in Health Care SBU and the Department of Medicine, Clinical Epidemiology Unit, Karolinska University Hospital, Stockholm, Sweden
    Emerg Med J 22:103-7. 2005
    ..To search the literature for case reports on adverse outcomes in patients with mild head injury where acute computed tomography (CT) findings had been normal...
  82. pmc Immediate and delayed traumatic intracranial hemorrhage in patients with head trauma and preinjury warfarin or clopidogrel use
    Daniel K Nishijima
    Department of Emergency Medicine, UC Davis School of Medicine, Sacramento, CA, USA
    Ann Emerg Med 59:460-8.e1-7. 2012
    ..The objective of this study is to address these gaps in knowledge...
  83. ncbi Pediatric neurotrauma in Kathmandu, Nepal: implications for injury management and control
    Karim Mukhida
    Division of Neurosurgery, University of Toronto, Toronto, Canada
    Childs Nerv Syst 22:352-62. 2006
    ..The epidemiology of acute pediatric neurotrauma in Kathmandu was studied to assess the implications of these data for injury prevention programs...
  84. ncbi Implementation of a guideline for computed tomography head imaging in head injury: a prospective study
    Christina Fong
    Monash Medical Centre, Southernhealth Care, Clayton, Victoria, Australia
    Emerg Med Australas 20:410-9. 2008
    ..To improve appropriate ordering of head computed tomography (CT) in patients presenting with a head injury by applying an evidence-based head injury guideline...
  85. ncbi Apolipoprotein E modifies the CNS response to injury via a histamine-mediated pathway
    Brian E Mace
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Neurol Res 29:243-50. 2007
    ..These results suggest that apoE modifies secondary neuronal injury caused by histamine release and are consistent with previous observations that apoE affects the CNS inflammatory response in an isoform-specific manner...
  86. pmc Assessment, investigation, and early management of head injury: summary of NICE guidance
    David Yates
    Trauma Audit and Research Network TARN, Manchester M6 8HD
    BMJ 335:719-20. 2007
  87. pmc An observational study of compliance with the Scandinavian guidelines for management of minimal, mild and moderate head injury
    Ben Heskestad
    Department of Neurosurgery, Oslo University Hospital Ulleval, Oslo, Norway
    Scand J Trauma Resusc Emerg Med 20:32. 2012
    ..The aim of the present study was to investigate guideline compliance after an educational intervention...
  88. ncbi Reasons for ordering computed tomography scans of the head in patients with minor brain injury
    Martin Rohacek
    Department of Emergency Medicine, Inselspital, University Hospital Bern, Bern, Switzerland
    Injury 43:1415-8. 2012
    ..We hypothesized that institutional guidelines are not frequently used, and that psychological factors are a common reason for ordering an unnecessary CT...
  89. ncbi A decrease in both mild and severe bicycle-related head injuries in helmet wearing ages--trend analyses in Sweden
    Peter Berg
    Department of Public Health and Caring Sciences and Social Medicine, Uppsala Science Park, SE 751 85 Uppsala, Sweden
    Health Promot Int 22:191-7. 2007
    ..The increasing helmet use among younger schoolchildren probably contributed to the decrease in head injuries...
  90. ncbi Abusive head trauma at a tertiary care children's hospital in Mexico City. A preliminary study
    Claudia Diaz-Olavarrieta
    National Institute of Public Health, Research Center on Health Population, Mexico City, Mexico
    Child Abuse Negl 35:915-23. 2011
    ....
  91. pmc Alcohol consumption, blood alcohol concentration level and guideline compliance in hospital referred patients with minimal, mild and moderate head injuries
    Marianne Efskind Harr
    Department of Neurosurgery, Oslo University Hospital Ulleval, Norway
    Scand J Trauma Resusc Emerg Med 19:25. 2011
    ....
  92. ncbi Canadian CT head rule study for patients with minor head injury: methodology for phase II (validation and economic analysis)
    I G Stiell
    Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Ann Emerg Med 38:317-22. 2001
    ..This will determine the clinical utility of the rule and is essential if such a rule is to be widely adopted into clinical practice...
  93. pmc Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults: an evidence and consensus-based update
    Johan Undén
    Department of Intensive Care and Perioperative Medicine, Institute for Clinical Sciences, Södra Förstadsgatan 101, 20502 Malmo, Sweden
    BMC Med 11:50. 2013
    ..In 2000, the Scandinavian Neurotrauma Committee (SNC) presented evidence-based guidelines for initial management of these injuries. Since then, considerable new evidence has emerged...
  94. ncbi Clinical decision rules for adults with minor head injury: a systematic review
    Sue E Harnan
    School of Health and Related Research, University of Sheffield, Sheffield, South Yorkshire, UK
    J Trauma 71:245-51. 2011
    ..This study aimed to systematically identify clinical decision rules for adults with minor head injury and compare the estimated diagnostic accuracies for any intracranial injury and injury requiring neurosurgical intervention...
  95. ncbi Head and traumatic brain injuries among Australian children, July 2000-June 2006
    Jesia G Berry
    Research Centre for Injury Studies, Flinders University, Adelaide, South Australia, Australia
    Inj Prev 16:198-202. 2010
    ..To describe the rates of hospitalisation for head and traumatic brain injury among Australian children aged 0-14 years...
  96. doi Non-accidental head injury--the evidence
    Timothy J David
    Department of Child Health, Booth Hall Children s Hospital, University of Manchester, Blackley, Manchester, M9 7AA, UK
    Pediatr Radiol 38:S370-7. 2008
  97. pmc Cerebral perfusion pressure and risk of brain hypoxia in severe head injury: a prospective observational study
    Antonio J Marín-Caballos
    Servicio de Cuidados Criticos y Urgencias, Hospitales Universitarios Virgen del Rocio, Avda Manuel Siurot s n, Seville, 41013, Spain
    Crit Care 9:R670-6. 2005
    ..We study the distribution of hypoxic PtiO2 samples at different CPP thresholds, using prospective multimodality monitoring in patients with severe traumatic brain injury...
  98. ncbi Which clinical features distinguish inflicted from non-inflicted brain injury? A systematic review
    S Maguire
    Child Health, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Arch Dis Child 94:860-7. 2009
    ..A systematic review of the scientific literature to define clinical indicators distinguishing inflicted (iBI) from non-inflicted brain injury (niBI)...
  99. ncbi Perfusion computed tomography in the acute phase of mild head injury: regional dysfunction and prognostic value
    Zwany Metting
    Department of Neurology, University Medical Center Groningen, Groningen, The Netherlands
    Ann Neurol 66:809-16. 2009
    ..Furthermore, the relation between perfusion CT parameters and severity of head injury and outcome was evaluated...
  100. ncbi Paediatric trauma: injury pattern and mortality in the UK
    J Bayreuther
    Paediatric A E, Fulham Road, Chelsea and Westminster Hospital, London, UK
    Arch Dis Child Educ Pract Ed 94:37-41. 2009
    ..Trauma accounts for a large proportion of childhood deaths. No data exist about injury patterns within paediatric trauma in the UK. Identification of specific high-risk injury patterns may lead to improved care and outcome...
  101. ncbi A systematic review of the diagnostic accuracy of ocular signs in pediatric abusive head trauma
    Gaurav Bhardwaj
    Faculty of Medicine, University of New South Wales, Randwick, NSW, Australia
    Ophthalmology 117:983-992.e17. 2010
    ..To review systematically the diagnostic accuracy of various ocular signs for pediatric abusive head trauma (AHT)...

Research Grants72

  1. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN IRA FADEN; Fiscal Year: 2010
    ..The Centers for Disease Control and Prevention (CDC) defines traumatic brain injury (TBI) as craniocerebral trauma associated with a decreased level of consciousness, amnesia, other neurologic or neuropsychological ..
  2. Emergency Neurophysiological Assessment Bedside Logic Engine
    Don M Tucker; Fiscal Year: 2010
    ..Network access technology will facilitate remote review by expert neurologists, and a training protocol will provide first-responder usability for emergency technicians and physicians without training in clinical neurophysiology. ..
  3. PARP inhibitor and Redox Catalyst Conjugate for Traumatic Brain Injury
    Kanneganti Murthy; Fiscal Year: 2012
    ..We are developing a novel drug that targets the basic mechanisms of this condition and will test this agent in a clinically-relevant animal model. ..
  4. Effect of Inducible Antioxidants on Hemoglobin Toxicity
    Raymond F Regan; Fiscal Year: 2010
    ..The ultimate goal is to reduce brain injury in tissue surrounding a blood clot, and to thereby improve the likelihood of survival and return to an independent, productive life. ..
  5. Novel non-invasive device for treatment of elevated intracranial pressures
    Keith G Lurie; Fiscal Year: 2011
    ....
  6. Investigation of Zinc Neurochemistry by Optical Sensing and MRI
    Stephen J Lippard; Fiscal Year: 2013
    ..Uncontrolled zinc levels contribute to neurodegenerative diseases, which may be responsive to zinc-selective chelating agents also devised in the project. ..
  7. Clinical Decision Support for Mild Traumatic Brain Injury
    EDWARD ROBERT MELNICK; Fiscal Year: 2013
    ..The tool will include special provisions for shared decision- making with the elderly, another AHRQ priority population. ..
  8. Elevated Zinc in Ischemia and reperfusion
    Yang V Li; Fiscal Year: 2013
    ....
  9. Development and Validation of a Diagnostic Tool for Infant Head Injuries from Fal
    SUSAN SHEPS contact MARGULIES; Fiscal Year: 2010
    ....
  10. Predict Near Future Bed Exit for Effective Intervention to Avoid Nighttime Falls
    THOMAS HENRY WHALEN; Fiscal Year: 2012
    ..Therefore, with a rapidly aging population, ever-increasing healthcare costs, and limited healthcare resources, there is significant and critical relevance to reducing the number of falls, and fall-related injuries among the elderly. ..
  11. Identifying neurons and circuits critical for epileptogenesis
    Istvan Mody; Fiscal Year: 2013
    ..The new discoveries will facilitate the translation of our basic findings into clinical practice. ..
  12. High School Student NeuroResearch Program (HSNRP)
    Marlys Hearst Witte; Fiscal Year: 2013
    ..Ongoing short-term and long-term evaluation including surveys, database registry and career portfolios will document efficacy of the training model and promote networking. ..
  13. Neuropeptide Modulation of ASICs
    Candice C Askwith; Fiscal Year: 2012
    ..ASIC1a represents an exciting new target for therapeutics to prevent brain injury and these studies will provide vital information to understand the fundamental mechanism of ASIC1a-induced neuronal death. ..
  14. Profiling human reactive astrocytes for neurotrauma biomarkers
    Ina Beate Wanner; Fiscal Year: 2012
    ....
  15. Group I Metabotropic Glutamate Receptors and Epileptogenesis
    Paul A Rutecki; Fiscal Year: 2013
    ....
  16. Meningioma: Risk Factors and Quality of Life
    Melissa L Bondy; Fiscal Year: 2010
    ..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningiomas. ..
  17. Meningioma: Risk Factors and Quality of Life
    Joellen M Schildkraut; Fiscal Year: 2010
    ..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..
  18. Meningioma: Risk Factors and Quality of Life
    Peter M Black; Fiscal Year: 2010
    ..This study represents the first concentratedeffort to examine environmental and genetic risk factors for meningioma. ..
  19. Meningioma: Risk Factors and Quality of Life
    Elizabeth B Claus; Fiscal Year: 2010
    ..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..
  20. Meningioma: Risk Factors and Quality of Life
    JOSEPH LEO WIEMELS; Fiscal Year: 2010
    ..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..
  21. Investigating the Role of Atg1 in the Regulation of Glutamate Receptors
    Faith Liebl; Fiscal Year: 2009
    ..Determining the role of atg1 in glutamate receptor cluster formation by analyses of atg1 mutants will improve our understanding of both autophagy and the mechanisms that govern glutamate receptor expression and location. ..
  22. Summers in Childrens Research for Diverse High School Students
    Marlys Hearst Witte; Fiscal Year: 2013
    ....
  23. TGF-beta Mediated Inflammatory Signaling: a Critical Role in Epileptogenesis
    Daniela Kaufer; Fiscal Year: 2012
    ..Since brain insults are one of the primary causes of disability with no means of prevention as of yet, this proposal represents an important advancement toward resolving this unmet medical need. ..
  24. Viscoelastic Properties of Human Facial Skin
    MARK WILLIAM BEATTY; Fiscal Year: 2012
    ..These objectives match those stated by RR&D as being key goals of this funding award. ..
  25. Canonical Transient Receptor Potential Channels and Excitotoxicity
    Fang Zheng; Fiscal Year: 2010
    ..In addition, the signaling studies mentioned in the abstract have been deleted. All else has remained the same since the proposed experiments to remain in the grant address the original scope of the grant. ..
  26. p75NTR Ligands for Treament of Traumatic Brain Injury
    Stephen M Massa; Fiscal Year: 2013
    ..The overall goal of this research is to advance the application of these neurotrophic compounds to the treatment of brain trauma and other conditions. ..
  27. Cognition in Parkinson's Disease
    DEBORAH LYNN HARRINGTON; Fiscal Year: 2013
    ..This knowledge could promote more optimal, individualized treatments and drive the development of new medication treatments. ..
  28. Failure of metabolite clearance in a model of multi-lacunar infarcts
    Maiken Nedergaard; Fiscal Year: 2013
    ..The proposed studies will provide fundamental new insight into cognitive impairment in vascular dementia, and will likely also improve our understanding of the pathophysiology of brain injury following stroke and head trauma. ..
  29. Ghrelin and Traumatic Brain Injury
    Rongqian Wu; Fiscal Year: 2012
    ..The relevance of this proposal to public health is to eventually use ghrelin in the treatment of patients with head injury. ..
  30. High-resolution ex vivo micro-computerized tomography system
    Mary F Barbe; Fiscal Year: 2010
    ..The acquisition of the SkyScan 1172 is essential for continued progress of these and future projects requiring this state-of-the-art technology. ..
  31. Dynamic Neuroimaging with High-resolution SSVEPs
    Ramesh Srinivasan; Fiscal Year: 2012
    ....
  32. CXCR4-Vagal Tone and Gastric motility
    Richard C Rogers; Fiscal Year: 2013
    ..Our hypothesis is that chemokines released as a function of the disease process directly affect the activity of cells in the brainstem that are responsible for essential digestion and feeding behavior control. ..
  33. Chronic Traumatic Encephalopathy: Clinical Presentation and Biomarkers
    Robert A Stern; Fiscal Year: 2013
    ..abstract_text> ..
  34. Facilitating Advancement in the Social Sciences
    CARRIE L SAETERMOE; Fiscal Year: 2010
    ....
  35. Calvarial periosteal afferents in post-traumatic headache
    Dan Levy; Fiscal Year: 2012
    ..Data collected will lead to further testable hypotheses on the cellular and molecular changes that contribute to the development of PTH. ..
  36. High Performance, Low Cost PET Scintillators
    Kanai S Shah; Fiscal Year: 2013
    ..Construction and evaluation of detector modules for PET imaging based on optically transparent ceramic garnet scintillators is also planned in the proposed effort. ..
  37. Molecular mechanisms of adult neurogenesis following traumatic brain injury
    MICHELLE LEE THEUS; Fiscal Year: 2010
    ..Our ultimate goal is to devise novel experimental therapies to treat brain injury and improve recovery of function in patients who sustain head trauma using adult neural stem cells. ..
  38. Mouse genetic differences in exercise-induced hippocampal neurogenesis &learning
    Justin S Rhodes; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The goal of this project is to discover mechanisms for pro cognitive effects of exercise at multiple levels of biological organization from genes to physiology to behavior. ..
  39. HMGB1 and Traumatic Brain Injury
    Krishnan M Dhandapani; Fiscal Year: 2013
    ..The results of these studies may support the future development of novel therapeutics directed against this pathway to limit neurological injury following head trauma. ..
  40. Neuronal Loss and Plasticity in Epilepsy
    Carolyn R Houser; Fiscal Year: 2013
    ..The broad goals of the studies are to identify progressive changes that could promote the development of epilepsy following status epilepticus or head trauma and thus provide a basis for designing treatments to prevent such changes. ..
  41. Goal-directed Resuscitative Interventions during Pediatric Inter-facility Transpo
    MICHAEL HUGH STROUD; Fiscal Year: 2011
    ..This study has the potential to change the current practice of pediatric inter-facility transport, and improve clinical outcomes of pediatric SIRS. ..
  42. Racial Stereotypes and the Recognition of Child Abuse
    Antoinette L Laskey; Fiscal Year: 2010
    ..Specific Aim 3 will be refinement and testing of this intervention and its effects on physicians'decision-making behavior in order to gather important data needed to develop a successful R01 application. ..
  43. Neural Interactions Among Multiple Motor Structures
    Marc H Schieber; Fiscal Year: 2010
    ..Such an improved understanding of the motor system can lead to improved rehabilitative treatment, and improved functional recovery after nervous system injury from diseases such as stroke and head trauma. ..
  44. NEUROBEHAVIORAL OUTCOME OF HEAD INJURY IN CHILDREN
    Harvey Levin; Fiscal Year: 2013
    ..Head injuries can cause teenagers to have problems with their friends. This study tries to figure out why head injuries cause these social problems and may help find ways to treat young people with a head injury. ..
  45. MR spectroscopic imaging to detect the development of latent epilepsy
    Jullie W Pan; Fiscal Year: 2013
    ..This will be done in a blinded fashion. As all animals will also be video and EEG monitored, we will also be able to test the ability of the MRSI to identify those animals who go on to develop overt recurrent seizures. ..
  46. Contributions of aberrant granule cell integration to the development of epilepsy
    Steve C Danzer; Fiscal Year: 2013
    ..By determining how normal brains become epileptic, we can begin to develop therapies to delay, halt and ultimately reverse the process. ..
  47. Biological Inquiry into the Mechanisms and Neuroprotective Strategy for TBI
    Dong Feng Chen; Fiscal Year: 2013
    ..If the hypothesis is proven valid, an innovative technology that has strong implications for translation into clinical practice could be developed in the near future. ..
  48. Role of BACE in the pathogenesis of Alzheimer's disease after head trauma
    Giuseppina Tesco; Fiscal Year: 2013
    ..abstract_text> ..
  49. NMDA Receptor Dynamics After Brain Injury
    Anat Biegon; Fiscal Year: 2011
    ..The results may explain the failure of NMDAR antagonists in clinical trials and suggest novel strategies for treatment of brain injury. ..
  50. Altered synaptogenesis after albumin exposure: A model for post traumatic epilep
    Lydia J Wood; Fiscal Year: 2012
    ..Furthermore, by dissociating different effects of albumin on the development of synaptic reorganization, I expect to identify possible targets for therapeutic prevention of posttraumatic epileptogenesis. ..
  51. Chronic TBI Bcl 2-20:34 Protection Against Lowered Seizure Susceptibility
    Roi Ann Wallis; Fiscal Year: 2013
    ..To this end, we will also evaluate mitochondrial structure and function after CCI with and without treatment with the Bcl-220-34 peptide. ..
  52. Field Triage of Head Injured Older Adults Taking Anticoagulants or Platelet Inhib
    DANIEL KIDEN NISHIJIMA; Fiscal Year: 2013
    ....
  53. Brain injury due to soccer heading and opportunities for its mitigation
    MICHAEL LAWRENCE LIPTON; Fiscal Year: 2013
    ..Aim III (Intensive measurement): Determine the short-term effects on and variability in day-to-day cognitive function and PCS using an intensive measurement design. ..
  54. Factors Associated with Quality of Care Delivered to Children in US EDs
    James P Marcin; Fiscal Year: 2012
    ..abstract_text> ..
  55. High-Level Expression of Human EAAT3 for Biochemical and Structural Analysis
    DIANNE LYNN DECAMP; Fiscal Year: 2011
    ....
  56. Neuroplasticity-Based Technology for Executive Function Deficits in Concussion
    Brian T Miller; Fiscal Year: 2013
    ....
  57. 1/2 A Large-Scale Schizophrenia Association Study in Sweden
    Patrick F Sullivan; Fiscal Year: 2013
    ..We propose to do this using the largest and most comprehensively studied sample collection in the field and which includes both genetic and environmental risk factors. ..
  58. Console Electronics Upgrade for 11.7T MRI System
    Chien Ho; Fiscal Year: 2013
    ..Overall, the proposed equipment upgrade is critical for maintaining the 11.7T instrument as a state-of-the-art system to support ongoing research for 5 Major and 12 Minor users. ..
  59. Long Term Outcomes in ICU Patients: Delirium & Apolipoprotein E
    Sheila Alexander; Fiscal Year: 2009
    ..This would likely lead to decreased time in the ICU and hospital. ..
  60. Effectiveness of bicycle helmet laws in preventing injuries among youth
    Pinka Chatterji; Fiscal Year: 2010
    ..The results from this study will provide policymakers with new, important information not only about the effectiveness of existing helmet laws, but also about how these laws can be designed to maximize their preventive benefits. ..
  61. The Epilepsy Phenome/ Genome Project (EPGP)
    Daniel H Lowenstein; Fiscal Year: 2013
    ....
  62. Basic Mechanisms of the Epilepsies Workshops
    Antonio Delgado Escueta; Fiscal Year: 2009
    ..5 million persons) and worldwide (50-100 million persons) and still there are no cures and treatments that put a dent in the stable prevalence and incident rates of the epilepsies. ..
  63. HYPOTHERMIA AND TRAUMA
    Larry Jenkins; Fiscal Year: 2000
    ....
  64. REGULATING CEREBROSPINAL FLUID FORMATION
    Barry Hoffer; Fiscal Year: 1992
    ..It is planned that promising animal studies will be followed up by clinical study proposals...
  65. NAAG Peptidase Inhibitors for the Treatment of Traumatic Brain Injury
    Jia Zhou; Fiscal Year: 2009
    ....
  66. CHILD AND FAMILY FUNCTIONING AFTER PEDIATRIC HEAD TRAUMA
    JoAnne Youngblut; Fiscal Year: 2001
    ..If nursing research and care can facilitate achieving these objectives, burden on health care, educational, and family systems will be reduced. ..
  67. APOLIPOPROTEIN E AND THE ISCHEMIC BRAIN
    David Warner; Fiscal Year: 2001
    ..We believe that this information would be of substantial value in defining both the relevance of Apo E mechanisms to ischemic outcome and provide a basis for therapeutic approaches to the treatment of stroke. ..
  68. BEHAVIORAL EFFECTS OF BRAIN INJURY
    Suzanne Corkin; Fiscal Year: 1990
    ....
  69. MUSCARINIC RECEPTOR COUPLING TO INOSITIDES IN CNS
    Stephen Fisher; Fiscal Year: 2006
    ..Accordingly, knowledge of the signal transduction pathways that regulate VSOAC is an essential prerequisite for the rational design of therapeutic agents. ..
  70. Revitalizing Allografts for Craniofacial Reconstruction
    Edward Schwarz; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  71. PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURY
    Ivan Soltesz; Fiscal Year: 2001
    ....