Genomes and Genes
spinal cord neoplasms
Summary: Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
Publications282 found, 100 shown here
- Spinal dumbbell tumors: an analysis of a series of 118 casesHiroshi Ozawa
Department of Orthopaedic Surgery, Tohoku University School of Medicine, Sendai, Japan
J Neurosurg Spine 7:587-93. 2007..The authors analyzed a series of 118 cases of spinal dumbbell tumors to elucidate the feature of the tumors...
- Spinal neurinomas: retrospective analysis and long-term outcome of 179 consecutively operated cases and review of the literaturePiero Conti
Department of Neurosurgery, University of Florence, Florence, Italy
Surg Neurol 61:34-43; discussion 44. 2004..We decided to limit the retrospective study to obtain at least 5 years of follow-up. Therefore, 20 additional neurinomas treated between 1997 and 2002 were excluded...
- Solitary intramedullary spinal cord tumor presenting as the initial manifestation of metastatic renal cell carcinoma: case reportDaniel J Donovan
Neurosurgery Service, Department of Surgery, Tripler Army Medical Center, Honolulu, HI 96859 5000, USA
Spine (Phila Pa 1976) 31:E460-3. 2006..We present the case of a patient with a solitary neoplasm of the intramedullary spinal cord...
- Surgical results of intradural extramedullary tumorsKyung Won Song
Department of Orthopaedic Surgery, Kangdong Sacred Heart Hospital, Hallym University School of Medicine, Seoul, Korea
Clin Orthop Surg 1:74-80. 2009..To report the treatment results of 12 patients who underwent a total excision of intradural extramedullary tumors...
- Spinal leptomeningeal metastasis from cerebral glioblastoma multiforme presenting with radicular pain: case report and literature reviewS Alatakis
Department of Neurosurgery, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
Surg Neurol 56:33-7; discussion 37-8. 2001..Awareness of this condition will facilitate appropriate intervention...
- Breast adenocarcinoma metastatic to epidural cervical spine meningioma: case report and review of the literatureManish Aghi
Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA
J Neurooncol 75:149-55. 2005..Metastasis to meningioma must be considered in an epidural spinal lesion in all patients with a known malignancy, with surgical aggressiveness tailored to the intraoperative pathologic diagnosis...
- Minimally invasive resection of intradural-extramedullary spinal neoplasmsTrent L Tredway
Department of Neurosurgery, University of Washington, Seattle, Washington, USA
Neurosurgery 58:ONS52-8; discussion ONS52-8. 2006..Traditional treatment of these tumors includes open laminectomy with intradural resection. We describe an alternative minimally invasive surgical technique in a consecutive series of patients undergoing treatment for symptomatic lesions...
- Intradural, extramedullary spinal cord granular cell tumor: a case report and clinicopathologic review of the literatureBrian J Weinstein
Department of Pathology, Southern California Permanente Medical Group, Woodland Hills, California, USA
Neuropathology 30:621-6. 2010..Histologic recognition of this rare tumor is important because the subsequent clinical course of the disease differs from other similar lesions...
- Intramedullary spinal cord metastasis (ISCM) in renal cell carcinoma: a series of six casesM Fakih
Department of Medicine, University of Pittsburgh, PA 15213 2582, USA
Ann Oncol 12:1173-7. 2001..Although no major improvements in neurological function were noted, stabilizations were common. This prolonged their ability to live independently, a matter of utmost importance in these terminally ill patients...
- Spinal cord glioblastoma multiforme induced by radiation after treatment for Hodgkin disease. Case reportChing Ng
Department of Radiation Oncology, The Prince of Wales Cancer Centre, Randwick, New South Wales, Australia
J Neurosurg Spine 6:364-7. 2007..The authors report on a 26-year-old man with a very rare case of radiation-induced intramedullary spinal cord glioblastoma multiforme, which developed several years after radiotherapy for Hodgkin disease...
- Intramedullary ancient schwannoma of the cervical spinal cord: case report and review of literatureB S Darwish
Department of Neurosurgery, Capital Coast Health, Wellington Hospital, Wellington, New Zealand
J Clin Neurosci 9:321-3. 2002..This plexus was found mostly to exist along the branches of the anterior spinal artery. In our case, the tumour was supplied by two branches of the anterior spinal artery, which may add further support to the above theory...
- Radiation-induced spinal cord glioma subsequent to treatment of Hodgkin's disease: case report and reviewLaurent Riffaud
Department of Neurosurgery, Pontchaillou Hospital, Rennes University, Rennes, France
J Neurooncol 76:207-11. 2006..The very limited survival associated with these tumors regardless of therapy advocates palliative therapies without attempting complete resection...
- Unilateral hemilaminectomy for patients with intradural extramedullary tumorsCai Xing Sun
Zhejiang Traditional Medical University, Hangzhou 310009, China
J Zhejiang Univ Sci B 12:575-81. 2011....
- Minimally invasive microsurgical treatment of cervical intraspinal extramedullary tumorsYong Yu
Department of Neurosurgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China
J Clin Neurosci 18:1168-73. 2011....
- Intramedullary neuroma of the cervicomedullary junction. Case reportSandro Santagata
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02130, USA
J Neurosurg Spine 5:362-6. 2006..This case may represent the first true traumatic intramedullary neuroma of the CMJ diagnosed in a living patient and treated surgically...
- Localized cervical pruritus as the presenting symptom of a spinal cord tumorDavid Magilner
Department of Emergency Medicine, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157 1089, USA
Pediatr Emerg Care 22:746-7. 2006..Her presenting symptom was right-sided cervical pruritus, which progressed to pain over the course of several months. Pruritus as a symptom of spinal cord pathology is discussed...
- Hemilaminectomy for removal of extramedullary or extradural spinal cord tumors: medium to long-term clinical outcomesToshitaka Naganawa
Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu, Japan
Yonsei Med J 52:121-9. 2011..The present study was performed to evaluate the clinical outcomes, including spinal sagittal alignment of patients, associated with spinal cord tumors treated by surgical excision using hemilaminectomy...
- Management of spinal meningiomas: surgical results and a review of the literatureMatthias Setzer
Neurosurgical Clinic, Neurocenter, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Neurosurg Focus 23:E14. 2007..In this report, the authors describe their experience in the surgical management of spinal meningiomas at two neurosurgical centers. The results of a literature review are also presented...
- Recurrence of benign spinal neoplasmsU Schick
Clinic of Neurological Surgery, University of Leipzig, Germany
Neurosurg Rev 24:20-5. 2001..Benign tumours recur in 10.2% of cases, thus requiring long-term follow-up. Magnetic resonance imaging (MRI) studies are recommended up to 5 years postoperatively as a routine procedure...
- Extramedullary intradural spinal tumors: a pictorial reviewDouglas P Beall
Department of Radiological Sciences, University of Oklahoma Health Science Center, Oklahoma City, OK 73103, USA
Curr Probl Diagn Radiol 36:185-98. 2007..We discuss imaging features that are typical for the various entities and describe various therapeutic options that are important considerations for surgical treatment of these lesions...
- Glioblastoma with spinal seedingNegar Fakhrai
Clinical Division of Oncology, Department of Medicine I, University of Vienna, Austria
Strahlenther Onkol 180:455-7. 2004..This case report describes two patients suffering from GBM with spinal seeding. In both cases, the anatomic localization of the primary tumor close to the cerebrospinal fluid (CSF) was the main factor for spinal seeding...
- Stereotactic radiosurgery yields long-term control for benign intradural, extramedullary spinal tumorsSean Sachdev
Department of Radiation Oncology, Stanford University Cancer Center, Stanford, California, USA
Neurosurgery 69:533-9; discussion 539. 2011..Although a growing body of evidence supports its role in the treatment of malignant spinal lesions, a much less extensive dataset exists for treatment of benign spinal tumors...
- Spinal meningiomas in patients younger than 50 years of age: a 21-year experienceAaron A Cohen-Gadol
Department of Neurologic Surgery, Mayo Medical School, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
J Neurosurg 98:258-63. 2003..Spinal meningiomas occurring in younger patients may be more aggressive, with a worse prognosis. The authors present their 21-year experience with spinal meningiomas in patients younger than 50 years of age...
- Unilateral partial hemilaminectomy in the removal of a large spinal ependymomaNaci Balak
Department of Neurosurgery, Bakirkoy Dr Sadi Konuk Education and Research Hospital, Istanbul, Turkey
Spine J 8:1030-6. 2008..Although the hemilaminectomy technique is known to neurosurgeons performing spinal surgery, laminectomy traditionally has been used during spinal canal surgery for extirpation of spinal cord tumors...
- Surgical management of ventral intradural spinal lesionsPeter D Angevine
Columbia University College of Physicians and Surgeons, Department of Neurological Surgery, New York, New York, USA
J Neurosurg Spine 15:28-37. 2011..In this study, the authors review their experience with 35 consecutive cases of ventral intradural spinal lesions...
- Part I: spinal-cord neoplasms-intradural neoplasmsDavid E Traul
Department of Neurology, University of Virginia Health System, Charlottesville, VA 22908, USA
Lancet Oncol 8:35-45. 2007..In this Review, we discuss the published work on intradural spinal-cord tumours in terms of epidemiological, radiographic, and histological characteristics. Surgical and adjuvant treatment strategies are also reviewed...
- The transspinous mini-open approach for resection of intradural spinal neoplasms: cadaveric feasibility study and report of 3 clinical casesDaniel C Lu
Department of Neurological Surgery, University of California, Los Angeles, California, USA
World Neurosurg 74:195-9. 2010..Here, we demonstrate the feasibility and initial clinical experience with a new minimally invasive approach for resection of intradural tumors...
- Cases of glioblastoma multiforme metastasizing to spinal cordMetehan Karaca
Department of Radiation Oncology, Ankara University Faculty of Medicine, Cebeci Hospital, Dikimevi Ankara, Turkey
Neurol India 54:428-30. 2006..Leptomeningeal metastasis and dissemination were diagnosed with magnetic resonance imaging. Radiotherapy provided only temporary relief from pain with small improvement in neurological deficit but no survival advantage...
- A novel intravertebral tumor model in rabbitsEric Amundson
Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Neurosurgery 57:341-6; discussion 341-6. 2005....
- Surgical experience of 120 patients with lumbosacral lipomasH Arai
Department of Neurosurgery, Juntendo University, Tokyo, Japan
Acta Neurochir (Wien) 143:857-64. 2001..Concerning prophylactic surgery for asymptomatic patients, the former group of patients are obviously good candidates, but the latter group is not...
- Surgical outcome of a posterior approach for large ventral intradural extramedullary spinal cord tumorsChi Heon Kim
Department of Neurosurgery, Seoul National University Hospital, Seoul, South Korea
Spine (Phila Pa 1976) 36:E531-7. 2011..Case series...
- Impact of tumor histology on resectability and neurological outcome in primary intramedullary spinal cord tumors: a single-center experience with 102 patientsIsaac O Karikari
Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
Neurosurgery 68:188-97; discussion 197. 2011..Surgical outcomes for intramedullary spinal cord tumors are affected by many variables including tumor histology and preoperative neurological function...
- Spinal cord compression in metastatic prostate cancerH Tazi
Service d Urologie, Centre Hospitalier Universitaire Pontchaillou, Rue Henri Le, Guilloux, 35033 cedex, Rennes, France
Eur Urol 44:527-32. 2003..Spinal cord compression (SCC) in metastatic prostate cancer is not rare occurring in 1 to 12% of patients. We have analysed patients treated for this condition in our institution assessing outcome and prognostic factors...
- Evaluation of functional outcome and local control after radiotherapy for metastatic spinal cord compression in patients with prostate cancerDirk Rades
Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
J Urol 175:552-6. 2006..This study investigates prognostic factors and radiation schedules for functional outcome and local control of MSCC after radiotherapy in patients with prostate cancer...
- Intradural disc mimicking: a spinal tumor lesionM V Aydin
Department of Neurosurgery, Baskent University Medical School, Turkey
Spinal Cord 42:52-4. 2004..A case report of intradural disc hernia mimicking an intradural extramedullary spinal tumor lesion in radiological evaluation...
- A population-based study of malignant spinal cord compression in OntarioD A Loblaw
Division of Cancer Care and Epidemiology, Queen s Cancer Research Institute, Queen s University, Kingston Regional Cancer Centre and Kingston General Hospital, Kingston, Ontario, Canada
Clin Oncol (R Coll Radiol) 15:211-7. 2003..Population-based cohort study...
- Spinal and extracranial metastatic dissemination of malignant gliomaWai Hoe Ng
Department of Neurosurgery, National Neuroscience Institute, Tan Tock Seng, Singapore
J Clin Neurosci 12:379-82. 2005..The pathophysiology and natural history of this condition is still not fully understood, hence well-designed prospective studies are needed...
- Neurosurgical management of intramedullary spinal cord tumors in childrenKarl F Kothbauer
Division of Neurosurgery, Department of Surgery, Kantonsspital Luzern, Postfach, Luzern, Switzerland
Pediatr Neurosurg 43:222-35. 2007..g. lasers and intraoperative neurophysiological monitoring with motor evoked potentials. High-grade tumors are resected conservatively and treated with radiation and chemotherapy. The prognosis of high-grade glial tumors remains poor...
- Intramedullary spinal cord metastases: diagnosis and treatment - an illustrated reviewM Kalayci
Department of Neurosurgery, Zonguldak Karaelmas University Medical School, Zonguldak, Turkey
Acta Neurochir (Wien) 146:1347-54; discussion 1354. 2004..Optimum treatment remains controversial. On the basis of a review of previous reports and experience with a patient with an ISCM from a large cell lung cancer, we propose practical diagnostic and therapeutic approaches...
- Surgical pathology of spinal schwannomas: a light and electron microscopic analysis of tumor capsulesM Hasegawa
Department of Neurosurgery, Kanazawa University School of Medicine, Kanazawa, Japan
Neurosurgery 49:1388-92; discussion 1392-3. 2001..Although spinal schwannomas are often encountered, the pathology of the tumor capsule has not been reported. In this study, we describe the ultrastructural pathology of the tumor capsule of spinal schwannomas...
- Clinical characteristics of spinal nerve sheath tumors: analysis of 149 casesTakahiro Jinnai
Department of Neurosurgery, Ohtsu Municipal Hospital, Ohtsu, Japan
Neurosurgery 56:510-5; discussion 510-5. 2005..This article describes the growth pattern of a spinal nerve sheath tumor along the spinal nerve root at various spinal levels...
- Surgical management of spinal cord hemangioblastomas in patients with von Hippel-Lindau diseaseRussell R Lonser
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
J Neurosurg 98:106-16. 2003....
- MR imaging of a case of a dumbbell-shaped spinal schwannoma with intramedullary and intradural-extramedullary componentsK Kono
Department of Radiology, Izumi Municipal Hospital, Isumi-shi, Japan
Neuroradiology 43:864-7. 2001..Before surgery, the tumor was clearly revealed as a mass with two components, intramedullary and extramedullary, on MRI, and it could be useful for operation. We discuss the possible pathogenesis of this tumor...
- The high incidence of tumor dissemination in myxopapillary ependymoma in pediatric patients. Report of five cases and review of the literatureDaniel R Fassett
Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah 84113, USA
J Neurosurg 102:59-64. 2005..In pediatric patients MPEs may spread throughout the CNS via cerebrospinal fluid pathways; therefore, MR imaging of the entire CNS axis is recommended at both presentation and follow-up review to detect tumor dissemination...
- Magnetic resonance imaging of intramedullary spinal cord schwannomas. Report of two cases and review of the literatureCesare Colosimo
Department of Clinical Sciences and Bioimaging, Neuroradiology Section, Institute of Advanced Biomedical Technology, Gabriele d Annunzio University of Chieti, School of Medicine, Chieti, Scalo, Italy
J Neurosurg 99:114-7. 2003..In cases in which an associated thickened Gd-enhancing spinal nerve root is seen the diagnosis of schwannoma should be assumed...
- [Prognostic factors in the treatment of the intradural extramedullary tumors: a study of 44 cases]Daniel Monte Serrat Prevedello
Departamento de Neurocirurgia, Hospital Nossa Senhora das Gracas, Brasil
Arq Neuropsiquiatr 61:241-7. 2003..Total resection is the ideal modality of surgical treatment. However, at the thoracic level, where the peculiarities of spine irrigation prevail, surgical morbidade may be higher (p=0.014)...
- Glioblastoma multiforme of the conus medullaris in a child: description of a case and literature reviewAlessandro Stecco
SCDU Radiologia, AO Maggiore della Carità, Novara, Italy
AJNR Am J Neuroradiol 26:2157-60. 2005..Nine months after the surgical treatment, the patient showed leptomeningeal recurrence. This case appears to be unusual for both the hysto-type and the nonspecific MR imaging features...
- Pediatric spinal cord tumors and massesPamela E Wilson
Department of Physical Medicine and Rehabilitation, B285, The Children s Hospital, 1056 E 19th Avenue, Denver, Colorado 80218, USA
J Spinal Cord Med 30:S15-20. 2007..This study presents detailed information regarding clinical presentation, histological findings, outcomes, functional assessment, and management of a series of patients with this diagnosis...
- Long term outcome with post-operative radiation therapy for spinal canal ependymomaSasha H Wahab
Department of Radiation Oncology, Washington University School of Medicine, 4921 Parkview Place, Lower Level, St Louis, MO 63110, USA
J Neurooncol 83:85-9. 2007..A retrospective study was performed to evaluate the long term efficacy and safety of post-operative radiation therapy in the management of spinal canal ependymoma at our institution...
- The natural history of hemangioblastomas of the central nervous system in patients with von Hippel-Lindau diseaseJohn E Wanebo
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
J Neurosurg 98:82-94. 2003....
- Imaging features and treatment of an intradural lumbar cystic schwannomaGuilherme Borges
Neurology and Neurosurgery Department, State University of Campinas UNICAMP, Campinas, SP, Brazil
Arq Neuropsiquiatr 63:681-4. 2005..The patient presented with complete recovery of his symptom. In this article we aim to emphasize the clinical presentation and treatment of lumbar spine schwannomas, and to illustrate the imaging findings within this uncommon case...
- Outcome following decompressive surgery for different histological types of metastatic tumors causing epidural spinal cord compression. Clinical articleKaisorn L Chaichana
Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
J Neurosurg Spine 11:56-63. 2009..The differential outcomes for patients with different histological types of metastatic disease therefore remain unknown...
- MR findings in spinal hemangioblastoma: correlation with symptoms and with angiographic and surgical findingsB C Chu
Department of Radiology, Hokkaido University School of Medicine, Sapporo, Japan
AJNR Am J Neuroradiol 22:206-17. 2001..CONCLUSION: Knowledge of these MR features helps to differentiate spinal hemangioblastoma from other diseases that show enhancing nodules...
- Resection of thoracic dumbbell neurinomas: single postero-lateral approach or combined posterior and transthoracic approach?M Payer
Department of Neurosurgery, University Hospital of Geneva, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
J Clin Neurosci 13:690-3. 2006..We report the removal of a dumbbell neurinoma at T6/7 using a single posterior midline approach with laminectomy and costo-transversectomy and review the literature regarding the approaches to thoracic dumbbell tumours...
- Intramedullary and spinal canal tumors in patients with neurofibromatosis 2: MR imaging findings and correlation with genotypeN J Patronas
Department of Diagnostic Radiology, Clinical Center, National Institutes of Health, 10 Center Dr, MSC 1182, Rm 1C660, Bethesda, MD 20892 1182, USA
Radiology 218:434-42. 2001....
- Results after surgery for lumbosacral lipoma: the significance of early and late worseningF van Calenbergh
Department of Neurosurgery, University Hospital Gasthuisberg, Catholic University, Herestraat 49, B 3000 Leuven, Belgium
Childs Nerv Syst 15:439-42; discussion 443. 1999..This can be interpreted as an argument against prophylactic surgery in asymptomatic patients...
- Pediatric intramedullary spinal cord tumorsKurtis I Auguste
Department of Neurological Surgery, University of California, San Francisco, CA 94143 0112, USA
Neurosurg Clin N Am 17:51-61. 2006
- Spinal hemangioblastoma containing metastatic renal cell carcinoma in von Hippel-Lindau disease. Case report and review of the literatureMeric A Altinoz
Department of Neurosurgery, Brain Tumour Research Center, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
J Neurosurg Spine 3:495-500. 2005..A review of the literature revealed that RCC-to-CNS hemangioblastoma is the second most common donor-recipient tumor association among the tumor-to-tumor metastases...
- Postoperative changes of spinal curvature and range of motion in adult patients with cervical spinal cord tumors: analysis of 51 cases and review of the literatureTakashi Asazuma
Department of Orthopaedic Surgery, National Defense Medical College, Saitama, Japan
J Spinal Disord Tech 17:178-82. 2004..We sought to determine factors likely to influence postoperative changes in cervical spinal curvature and range of motion (ROM) in patients with cervical spinal cord tumors...
- Intramedullary spinal tumors of disordered embryogenesisK Muraszko
Department of Pediatric Neurosurgery, University of Michigan, Ann Arbor 48109 0339, USA
J Neurooncol 47:271-81. 2000..Proper surgical management of these various conditions necessitates a thorough understanding of their embryologic etiology and the anatomic/physiologic ramifications that such lesions have on the developing spinal cord...
- Neurofibromatosis 2 in the pediatric populationFabio Nunes
Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
J Child Neurol 18:718-24. 2003..Further work is needed to determine optimal management of pediatric neurofibromatosis 2...
- Neurofibromatosis type 2 diagnosed in the absence of vestibular schwannomas. A case report and guidelines for a screening protocol for children at riskA J Janse
Department of Paediatrics, Wilhelmina Children's Hospital, Utrecht, The Netherlands
Eur J Pediatr 160:439-43. 2001..In these cases molecular studies may provide additional evidence for the diagnosis. We propose guidelines for a screening protocol for children at risk for having neurofibromatosis type 2...
- Intramedullary spinal cord tumors in childrenGeorge I Jallo
Division of Pediatric Neurosurgery, Johns Hopkins Hospital, 600 North Wolfe Street, Harvey 811, Baltimore, MD 21287, USA
Childs Nerv Syst 19:641-9. 2003..Pediatric intramedullary spinal cord tumors are rare and make up only a small percentage of all central nervous system neoplasms...
- Metastases to hemangioblastomas in von Hippel-Lindau diseaseS Taylor Jarrell
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
J Neurosurg 105:256-63. 2006....
- Spinal cord astrocytomas: presentation, management, and outcomeChan Roonprapunt
Department of Neurosurgery, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030, USA
Neurosurg Clin N Am 17:29-36. 2006
- Role of surgery for maintaining urological function and prevention of retethering in the treatment of lipomeningomyelocele: experience recorded in 75 lipomeningomyelocele patientsJoon Ki Kang
Department of Neurosurgery, Kangnam St Mary s Hospital, College of Medicine, The Catholic University of Korea, 505 Banpo dong Seocho gu, Seoul 137 040, Korea
Childs Nerv Syst 19:23-9. 2003....
- Surgical management of isolated hemangioblastomas of the spinal cordC Roonprapunt
Division of Pediatric Neurosurgery, Institute for Neurology and Neurosurgery, Beth Israel Medical Center, New York, New York 10128, USA
Neurosurgery 49:321-7; discussion 327-8. 2001..These tumors have characteristic imaging properties on magnetic resonance imaging and angiography. Surgical removal of these lesions results in excellent long-term functional outcome...
- Chromosomal abnormalities subdivide ependymal tumors into clinically relevant groupsY Hirose
Department of Neurological Surgery, University of California, San Francisco, CA 91943-0808, USA
Am J Pathol 158:1137-43. 2001..We conclude that cytogenetic analysis of ependymomas may help to classify these tumors and provide leads concerning their initiation and progression. The relationship of these aberrations to patient outcome needs to be addressed...
- Solitary fibrous tumor of the spinal cord: a clinicopathologic study of two casesStefano Pizzolitto
Department of Pathology and Laboratory Medicine, General Hospital S Maria della Misericordia, Udine, Italy
Ann Diagn Pathol 8:268-75. 2004....
- Clear cell ependymoma with a lipidized component that developed in the thoracic spinal cordYeong Jin Kim
Department of Neurosurgery, Higashiosaka City General Hospital, 3 4 5 Nishiiwata cho, Higashiosaka 578 8588, Japan
Neurol Res 25:324-8. 2003..The MIB-1 staining index was 0.25%. Based on these findings, diagnosis of clear cell ependymoma with a lipidized component was made...
- Intramedullary spinal cord tumors in patients older than 50 years of age: management and outcome analysisRaj K Shrivastava
Department of Neurosurgery, St Luke s Roosevelt Hospital Center, New York, New York, USA
J Neurosurg Spine 2:249-55. 2005..The authors examined their IMSCT database and report the first large series of IMSCTs in patients older than 50 years of age...
- Neurological outcome after resection of intramedullary spinal cord tumors in childrenMatthew J McGirt
Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
Childs Nerv Syst 24:93-7. 2008..Clinical and radiographic risk factors predictive of postoperative neurological outcome may serve as a guide for surgical risk stratification...
- Torticollis secondary to posterior fossa and cervical spinal cord tumors: report of five cases and literature reviewSefer Kumandas
Department of Pediatric Neurology, Erciyes University Medical School, Kayseri, Turkey
Neurosurg Rev 29:333-8; discussion 338. 2006..Although torticollis secondary to tumors is rarely seen, it is necessary to be kept in mind in the differential diagnosis...
- The natural history of conservatively managed symptomatic intramedullary spinal cord cavernomasSiddharth Kharkar
Neurosurgery 60:865-72; discussion 865-72. 2007..The objective is to provide additional information regarding the natural history of conservatively managed, symptomatic, intramedullary spinal cord cavernous malformations...
- Gene expression patterns in ependymomas correlate with tumor location, grade, and patient ageAndrey Korshunov
Department of Neuropathology, Neurosurgical Nikolai Nilovich Burdenko Institute, Moscow, Russia
Am J Pathol 163:1721-7. 2003..In summary, our results provide new insight in the biochemical pathways particularly intriguing in the pathomechanism of ependymomas and suggest that this entity comprises molecularly distinct diseases...
- Radical excision of intramedullary spinal cord tumors: surgical morbidity and long-term follow-up evaluation in 164 children and young adultsS Constantini
Institute for Neurology and Neurosurgery, Beth Israel Medical Center, New York, New York, USA
J Neurosurg 93:183-93. 2000..In an attempt to resolve this controversy, the long-term morbidity and survival in a large series of children have been retrospectively reviewed...
- Tumors of the spine in childrenAndrea Rossi
Department of Pediatric Neuroradiology, G Gaslini Children s Hospital, Largo G Gaslini 5, I 16147 Genoa, Italy
Neuroimaging Clin N Am 17:17-35. 2007..Magnetic resonance imaging provides crucial information regarding the extent, location, and internal structure of the mass, thus critically narrowing the differential diagnosis and guiding surgery...
- Intramedullary cavernous angioma of the spinal cord in a pediatric patient, with multiple cavernomas, familial occurrence and partial spontaneous regression: case report and review of the literatureAntonio Santoro
Department of Neurological Sciences Neurosurgery, University of Rome La Sapienza, Neurochirurgia1, Viale del Policlinico, 155, 00185 Rome, Italy
Childs Nerv Syst 23:1319-26. 2007..The authors present their experience with the 17th pediatric intramedullary cavernoma reported in English literature...
- Low back pain and sciatica as the presenting symptoms of neurinoma near the conus medullaris. Contribution of magnetic resonance imagingLatifa Harzallah
Joint Bone Spine 72:187-9. 2005
- Solitary fibrous tumor of the spinal nerve rootlet: report of a case mimicking schwannomaSimonetta Piana
Servizio di Anatomia ed Istologia Patologica, Ospedale Santa Maria Nuova, Reggio Emilia, Italy
Arch Pathol Lab Med 128:335-7. 2004..The present case suggests that solitary fibrous tumor should be considered in differentiating spindle cell lesions of the spinal cord and nerve rootlet...
- Analysis of chromosome 7 in adult and pediatric ependymomas using chromogenic in situ hybridizationMariarita Santi
Department of Pathology, Children s Hospital National Medical Center, Washington, DC, USA
J Neurooncol 72:25-8. 2005..These results encourage further investigations with CISH on a larger scale to determine its merit as an ancillary diagnostic and prognostic tool...
- Solitary fibrous tumor of the spinal cord: case report and review of the literatureMitsuhiro Kawamura
Department of Orthopedic Surgery, Osaka Seamen s Insurance Hospital, Osaka, Japan
Neurosurgery 55:433. 2004
- Intramedullary spinal cord ependymomas in children: treatment, results and follow-upM Lonjon
Service de Neurochirurgie, Hopital Pasteur, Nice, France
Pediatr Neurosurg 29:178-83. 1998..We conclude that a complete removal can be achieved in almost all cases of intramedullary spinal cord ependymomas in children, and that the long survival rates justify avoiding post-operative radiation therapy...
- Spinal cord gangliogliomas: a review of 56 patientsGeorge I Jallo
Johns Hopkins University School of Medicine, Division of Pediatric Neurosurgery, Baltimore, MD, USA
J Neurooncol 68:71-7. 2004..Patients have a long survival following radical surgery. These tumors have an indolent course, and radiotherapy appears to be unnecessary...
- The results of radiotherapy for ependymomas: the Mayo Clinic experienceS E Schild
Mayo Clinic Arizona, Department of Radiation Oncology, Scottsdale 85259, USA
Int J Radiat Oncol Biol Phys 42:953-8. 1998..This analysis was performed to examine the outcome of patients with histologically confirmed ependymomas of the brain or spinal cord who received postoperative radiotherapy...
- Recurrent spinal ependymoma showing partial remission under ImatimibN Fakhrai
Department of Medicine I, Clinical Division of Oncology, University of Vienna, Vienna, Austria
Acta Neurochir (Wien) 146:1255-8. 2004..There are few treatment options for recurrent spinal ependymoma after surgery and radiation therapy...
- Solitary fibrous tumour of the spinal cordJ P Mordani
Department of Radiology, City General Hospital, Stoke on Trent, UK
Neuroradiology 42:679-81. 2000..The tumour predominantly consisted of monomorphic spindle cells with a storiform pattern. MRI demonstrated an inhomogeneously enhancing cervical intramedullary tumour. The patient was well without recurrence 18 months after surgery...
- [Nocturnal back pain; a misdiagnosed symptom of spinal tumor]R J Groen
Slotervaart Ziekenhuis, afd Neurochirurgie, Louwesweg 6, 1066 EC Amsterdam
Ned Tijdschr Geneeskd 145:2134-8. 2001..The importance of recognising these early complaints is stressed. Nowadays, MRI is the technique of choice to answer the question whether there is a space occupying process in the spine...
- Spinal tumors in childrenMandy Binning
Department of Neurosurgery, University of Utah, 175 N Medical Drive East, 3B 409 SOM, Salt Lake City, UT 84132 2303, USA
Neurosurg Clin N Am 18:631-58. 2007..Rather, the key clinical, diagnostic, and therapeutic features of each tumor are discussed...
- Cervical intra-/extramedullary solitary fibrous tumourB Ogungbo
Department of Neurosurgery, James Cook University Hospital, Middlesbrough, UK
Br J Neurosurg 19:254-7. 2005..The final histology was a solitary fibrous tumour (SFT) of the cervical spinal cord. The radiological diagnosis, surgical management and histology are reviewed...
- [A rare cause of sciatica]T Amezyane
Clinique Medicale, HIA Val de Grace, 00446 ARMEES cedex, France
Rev Med Interne 27:494-6. 2006
- The clinical and surgical aspects of spinal tumors in childrenAlper Baysefer
Department of Neurosurgery, School of Medicine, Gulhane Military Medical Academy, Ankara, Turkey
Pediatr Neurol 31:261-6. 2004..Laminotomy was the main surgical method in 60% of the patients with spinal tumor, especially in children younger than 3 years of age...
- Outcome in 53 patients with spinal cord cavernomasPierre Labauge
Service de Neurologie, CHU de Nimes, 30029 France
Surg Neurol 70:176-81; discussion 181. 2008..Prevalence of cerebral cavernomas in the general population is close to 0.5%. In contrast, SCCs are rare. The aim of this study was to determine the outcome of SCC in a large sample of patients...
- Enlargement of the spinal cord: inflammation or neoplasm?Marko Brinar
University Department of Internal Medicine, Zagreb School of Medicine and University Hospital Center, Kispaticeva 12, Zagreb, Croatia
Clin Neurol Neurosurg 108:284-9. 2006....
- Intramedullary cavernous angiomas of the spinal cord in the pediatric age group: a pediatric seriesMahmoud G Nagib
Neurosurgical Associates Ltd, Minneapolis, MN 55407, USA
Pediatr Neurosurg 36:57-63. 2002..MRI of the entire neuraxis is recommended for lesion multiplicity. An attempt at total resection and long-term MRI follow-up are recommended...
- Extent of surgical resection of malignant astrocytomas of the spinal cord: outcome analysis of 35 patientsMatthew J McGirt
Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, Maryland 21218, USA
Neurosurgery 63:55-60; discussion 60-1. 2008..We report the outcomes of the surgical management of 35 malignant spinal cord astrocytomas and assess the association of extent of resection with survival after aggressive resection of these tumors...
- Long term outcomes following surgical resection of myxopapillary ependymomasCarlos A Bagley
Division of Neurosurgery, Duke University School of Medicine, Durham, NC, USA
Neurosurg Rev 32:321-34; discussion 334. 2009..Excellent outcomes may be obtained, however, with the use of aggressive surgical techniques. No clear benefit for adjunctive chemotherapy, and radiation therapy was demonstrated...
- EpendymomasMarc C Chamberlain
Department of Neurology, USC Norris Cancer Center, 1441 Eastlake Avenue, Suite 3459, Los Angeles, CA 90033 0804, USA
Curr Neurol Neurosci Rep 3:193-9. 2003..Disease-free survival following recurrence is unusual (<15% at 5 years) and suggests intensification of initial adjuvant treatment may best prevent relapse...
- Intramedullary spinal cord cavernous malformations: clinical features and risk of hemorrhageIbrahim Erol Sandalcioglu
Department of Neurosurgery, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany
Neurosurg Rev 26:253-6. 2003..Based on the significant risk of rehemorrhage and the gratifying functional results, surgery is indicated for symptomatic IMSC cavernous malformations...
- Pediatric intramedullary spinal cavernous malformationsH Deutsch
Institute for Neurology and Neurosurgery, Beth Israel Medical Center, New York, New York 10128, USA
Spine (Phila Pa 1976) 26:E427-31. 2001..CONCLUSIONS: The surgical removal of these malformations results in a good functional outcome. The entire neuraxis should be screened because there is a high incidence of multiple lesions...
- Pediatric low-grade and ependymal spinal cord tumorsT E Merchant
Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Pediatr Neurosurg 32:30-6. 2000..Patients with disseminated EP, MPEP, JPA and nonpilocytic astrocytoma may achieve long-term progression-free survival with craniospinal irradiation...
- TARGETED THERAPY FOR CHEMORESISTANT TUMORSNina Schor; Fiscal Year: 2006..Ultimately, this predictive panel will help to identify those patients whose chemoresistant tumors are likely to be particularly sensitive to enediyne treatment. [unreadable] [unreadable]..
- NEUROTROPHIC MECHANISMS IN NEUROBLASTOMANina Schor; Fiscal Year: 2008..abstract_text> ..
- Polysomal RNA Antitumor ImmunityJohn Chi; Fiscal Year: 2005..Results from these experiments will help characterize the potential use of dendritic cells transfected with polysomal RNA in creating antigen specific tumor vaccines for brain tumors. ..
- NEURODEVELOPMENTAL AND NEURODEGERENTATIVE DISEASENina Schor; Fiscal Year: 2005..Funding of this program will perpetuate this history at an economically and academically critical time. ..
- Antioxidant Strategies for Parkinson's DiseaseNina Schor; Fiscal Year: 2005..abstract_text> ..
- Spatial-Temporal Imaging of Cell Proliferation & HypoxiaRobert Jeraj; Fiscal Year: 2007..unreadable] [unreadable]..
- Lapatinib in childhood CNS malignanciesMaryam Fouladi; Fiscal Year: 2006..These data will be used in the rational design of future phase I combination or frontline studies to improve the outcome in children with these poor prognosis tumors. [unreadable] [unreadable]..
- EARLY GENETIC EVENTS IN ASTROCYTOMA FORMATIONJOHN HENSON; Fiscal Year: 2003..As a way forward to new hypotheses, they will determine genome-wide changes in subsets of LGA patients with good and poor outcomes using comparative genomic hybridization (CGH). ..
- HIV and the Proteasome in the Aging Human BrainBenjamin Gelman; Fiscal Year: 2005..The linkage between brain inflammation and altered neuronal protein turnover could lead to a unifying functional concept of dementia with application to HIV and aging both. ..
- Dopamine Systems and Neuropsychiatric Changes in HIV/AIDSBenjamin B Gelman; Fiscal Year: 2010..The project breaks ground neuroscientifically, as no autopsy study has advanced to a "task specific" behavioral correlation with circuit level anomalies of a specific neurotransmitter system. ..
- MYELOPATHY AND NEUROPATHY DURING CHANGING HIV BURDENBenjamin Gelman; Fiscal Year: 2004..Together, the studies we have proposed will provide insights concerning prevalent AIDS morbidities in the HAART era. ..
- Indomethacin and p38 Regulating AP-1 In Heat ShockJacob Locke; Fiscal Year: 2004..abstract_text> ..
- Gene Transfer to Facilitate Dose-Intensification in the Treatment of Pediatric B*Lars Wagner; Fiscal Year: 2007..We hypothesize this strategy will be well tolerated and allow for meaningful dose escalation through chemoprotection afforded by gene transfer into hematopoietic stem cells. [unreadable] [unreadable] [unreadable]..
- TEXAS REPOSITORY FOR AIDS NEUROPATHOGENESIS RESEARCHBenjamin Gelman; Fiscal Year: 2007..abstract_text> ..
- Regulation- Medulloblastoma Growth by alpha-v integrinsTobey Macdonald; Fiscal Year: 2006..The long-range goal of this work is to broaden our understanding of medulloblastoma growth, so that novel biologic therapies may be developed into new treatments for medulloblastoma, the most common malignant brain tumor in children. ..
- Antigen specific modeling of glioma immunotherapyAndrew Parsa; Fiscal Year: 2007..The long-term goal of this proposal is to facilitate the development of Dr. Parsa into an independent investigator capable of making meaningful scientific contributions. ..
- Inhibition of the PI3 Kinase Pathway in Malignant Glioma by Convection Enhanced DJames Waldron; Fiscal Year: 2007..Demonstration of improved outcomes with combination therapy will support the development of human clinical trials using specific pathway inhibition to improve response to immunotherapy. [unreadable] [unreadable] [unreadable]..
- BODY WEIGHT SUPPORTED AMBULATION TRAINING AFTER SCIBlair Calancie; Fiscal Year: 2004..abstract_text> ..
- SPINAL MOTOR CONDUCTION AND RECOVERY AFTER HUMAN SCIBlair Calancie; Fiscal Year: 2009..A slow-release formulation the K-channel blocker 4-aminopyridine will be tested for its effects on conduction in some cases. ..
- PRE-CLINICAL STUDIES OF SPINAL-CORD INJURY REPAIRNurit Kalderon; Fiscal Year: 2004..g., dose protocol) at which repair is facilitated. Analysis of repair is conducted using magnetic resonance imaging of the lesion site at the cord, quantitative histologic and electrophysiologic methods and behavioral methods. ..