spinal cord neoplasms

Summary

Summary: Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.

Top Publications

  1. ncbi Spinal dumbbell tumors: an analysis of a series of 118 cases
    Hiroshi Ozawa
    Department of Orthopaedic Surgery, Tohoku University School of Medicine, Sendai, Japan
    J Neurosurg Spine 7:587-93. 2007
  2. ncbi Spinal neurinomas: retrospective analysis and long-term outcome of 179 consecutively operated cases and review of the literature
    Piero Conti
    Department of Neurosurgery, University of Florence, Florence, Italy
    Surg Neurol 61:34-43; discussion 44. 2004
  3. ncbi Solitary intramedullary spinal cord tumor presenting as the initial manifestation of metastatic renal cell carcinoma: case report
    Daniel J Donovan
    Neurosurgery Service, Department of Surgery, Tripler Army Medical Center, Honolulu, HI 96859 5000, USA
    Spine (Phila Pa 1976) 31:E460-3. 2006
  4. pmc Surgical results of intradural extramedullary tumors
    Kyung Won Song
    Department of Orthopaedic Surgery, Kangdong Sacred Heart Hospital, Hallym University School of Medicine, Seoul, Korea
    Clin Orthop Surg 1:74-80. 2009
  5. ncbi Spinal leptomeningeal metastasis from cerebral glioblastoma multiforme presenting with radicular pain: case report and literature review
    S Alatakis
    Department of Neurosurgery, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    Surg Neurol 56:33-7; discussion 37-8. 2001
  6. ncbi Breast adenocarcinoma metastatic to epidural cervical spine meningioma: case report and review of the literature
    Manish Aghi
    Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA
    J Neurooncol 75:149-55. 2005
  7. ncbi Minimally invasive resection of intradural-extramedullary spinal neoplasms
    Trent L Tredway
    Department of Neurosurgery, University of Washington, Seattle, Washington, USA
    Neurosurgery 58:ONS52-8; discussion ONS52-8. 2006
  8. ncbi Intradural, extramedullary spinal cord granular cell tumor: a case report and clinicopathologic review of the literature
    Brian J Weinstein
    Department of Pathology, Southern California Permanente Medical Group, Woodland Hills, California, USA
    Neuropathology 30:621-6. 2010
  9. ncbi Intramedullary spinal cord metastasis (ISCM) in renal cell carcinoma: a series of six cases
    M Fakih
    Department of Medicine, University of Pittsburgh, PA 15213 2582, USA
    Ann Oncol 12:1173-7. 2001
  10. ncbi Spinal cord glioblastoma multiforme induced by radiation after treatment for Hodgkin disease. Case report
    Ching Ng
    Department of Radiation Oncology, The Prince of Wales Cancer Centre, Randwick, New South Wales, Australia
    J Neurosurg Spine 6:364-7. 2007

Research Grants

  1. TARGETED THERAPY FOR CHEMORESISTANT TUMORS
    Nina Schor; Fiscal Year: 2006
  2. NEUROTROPHIC MECHANISMS IN NEUROBLASTOMA
    Nina Schor; Fiscal Year: 2008
  3. Polysomal RNA Antitumor Immunity
    John Chi; Fiscal Year: 2005
  4. NEURODEVELOPMENTAL AND NEURODEGERENTATIVE DISEASE
    Nina Schor; Fiscal Year: 2005
  5. Antioxidant Strategies for Parkinson's Disease
    Nina Schor; Fiscal Year: 2005
  6. Spatial-Temporal Imaging of Cell Proliferation & Hypoxia
    Robert Jeraj; Fiscal Year: 2007
  7. Lapatinib in childhood CNS malignancies
    Maryam Fouladi; Fiscal Year: 2006
  8. EARLY GENETIC EVENTS IN ASTROCYTOMA FORMATION
    JOHN HENSON; Fiscal Year: 2003
  9. HIV and the Proteasome in the Aging Human Brain
    Benjamin Gelman; Fiscal Year: 2005
  10. Dopamine Systems and Neuropsychiatric Changes in HIV/AIDS
    Benjamin B Gelman; Fiscal Year: 2010

Detail Information

Publications282 found, 100 shown here

  1. ncbi Spinal dumbbell tumors: an analysis of a series of 118 cases
    Hiroshi Ozawa
    Department of Orthopaedic Surgery, Tohoku University School of Medicine, Sendai, Japan
    J Neurosurg Spine 7:587-93. 2007
    ..The authors analyzed a series of 118 cases of spinal dumbbell tumors to elucidate the feature of the tumors...
  2. ncbi Spinal neurinomas: retrospective analysis and long-term outcome of 179 consecutively operated cases and review of the literature
    Piero Conti
    Department of Neurosurgery, University of Florence, Florence, Italy
    Surg Neurol 61:34-43; discussion 44. 2004
    ..We decided to limit the retrospective study to obtain at least 5 years of follow-up. Therefore, 20 additional neurinomas treated between 1997 and 2002 were excluded...
  3. ncbi Solitary intramedullary spinal cord tumor presenting as the initial manifestation of metastatic renal cell carcinoma: case report
    Daniel J Donovan
    Neurosurgery Service, Department of Surgery, Tripler Army Medical Center, Honolulu, HI 96859 5000, USA
    Spine (Phila Pa 1976) 31:E460-3. 2006
    ..We present the case of a patient with a solitary neoplasm of the intramedullary spinal cord...
  4. pmc Surgical results of intradural extramedullary tumors
    Kyung Won Song
    Department of Orthopaedic Surgery, Kangdong Sacred Heart Hospital, Hallym University School of Medicine, Seoul, Korea
    Clin Orthop Surg 1:74-80. 2009
    ..To report the treatment results of 12 patients who underwent a total excision of intradural extramedullary tumors...
  5. ncbi Spinal leptomeningeal metastasis from cerebral glioblastoma multiforme presenting with radicular pain: case report and literature review
    S Alatakis
    Department of Neurosurgery, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    Surg Neurol 56:33-7; discussion 37-8. 2001
    ..Awareness of this condition will facilitate appropriate intervention...
  6. ncbi Breast adenocarcinoma metastatic to epidural cervical spine meningioma: case report and review of the literature
    Manish Aghi
    Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA
    J Neurooncol 75:149-55. 2005
    ..Metastasis to meningioma must be considered in an epidural spinal lesion in all patients with a known malignancy, with surgical aggressiveness tailored to the intraoperative pathologic diagnosis...
  7. ncbi Minimally invasive resection of intradural-extramedullary spinal neoplasms
    Trent L Tredway
    Department of Neurosurgery, University of Washington, Seattle, Washington, USA
    Neurosurgery 58:ONS52-8; discussion ONS52-8. 2006
    ..Traditional treatment of these tumors includes open laminectomy with intradural resection. We describe an alternative minimally invasive surgical technique in a consecutive series of patients undergoing treatment for symptomatic lesions...
  8. ncbi Intradural, extramedullary spinal cord granular cell tumor: a case report and clinicopathologic review of the literature
    Brian J Weinstein
    Department of Pathology, Southern California Permanente Medical Group, Woodland Hills, California, USA
    Neuropathology 30:621-6. 2010
    ..Histologic recognition of this rare tumor is important because the subsequent clinical course of the disease differs from other similar lesions...
  9. ncbi Intramedullary spinal cord metastasis (ISCM) in renal cell carcinoma: a series of six cases
    M Fakih
    Department of Medicine, University of Pittsburgh, PA 15213 2582, USA
    Ann Oncol 12:1173-7. 2001
    ..Although no major improvements in neurological function were noted, stabilizations were common. This prolonged their ability to live independently, a matter of utmost importance in these terminally ill patients...
  10. ncbi Spinal cord glioblastoma multiforme induced by radiation after treatment for Hodgkin disease. Case report
    Ching Ng
    Department of Radiation Oncology, The Prince of Wales Cancer Centre, Randwick, New South Wales, Australia
    J Neurosurg Spine 6:364-7. 2007
    ..The authors report on a 26-year-old man with a very rare case of radiation-induced intramedullary spinal cord glioblastoma multiforme, which developed several years after radiotherapy for Hodgkin disease...
  11. ncbi Intramedullary ancient schwannoma of the cervical spinal cord: case report and review of literature
    B S Darwish
    Department of Neurosurgery, Capital Coast Health, Wellington Hospital, Wellington, New Zealand
    J Clin Neurosci 9:321-3. 2002
    ..This plexus was found mostly to exist along the branches of the anterior spinal artery. In our case, the tumour was supplied by two branches of the anterior spinal artery, which may add further support to the above theory...
  12. ncbi Radiation-induced spinal cord glioma subsequent to treatment of Hodgkin's disease: case report and review
    Laurent Riffaud
    Department of Neurosurgery, Pontchaillou Hospital, Rennes University, Rennes, France
    J Neurooncol 76:207-11. 2006
    ..The very limited survival associated with these tumors regardless of therapy advocates palliative therapies without attempting complete resection...
  13. pmc Unilateral hemilaminectomy for patients with intradural extramedullary tumors
    Cai Xing Sun
    Zhejiang Traditional Medical University, Hangzhou 310009, China
    J Zhejiang Univ Sci B 12:575-81. 2011
    ....
  14. ncbi Minimally invasive microsurgical treatment of cervical intraspinal extramedullary tumors
    Yong Yu
    Department of Neurosurgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China
    J Clin Neurosci 18:1168-73. 2011
    ....
  15. ncbi Intramedullary neuroma of the cervicomedullary junction. Case report
    Sandro Santagata
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02130, USA
    J Neurosurg Spine 5:362-6. 2006
    ..This case may represent the first true traumatic intramedullary neuroma of the CMJ diagnosed in a living patient and treated surgically...
  16. ncbi Localized cervical pruritus as the presenting symptom of a spinal cord tumor
    David Magilner
    Department of Emergency Medicine, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157 1089, USA
    Pediatr Emerg Care 22:746-7. 2006
    ..Her presenting symptom was right-sided cervical pruritus, which progressed to pain over the course of several months. Pruritus as a symptom of spinal cord pathology is discussed...
  17. pmc Hemilaminectomy for removal of extramedullary or extradural spinal cord tumors: medium to long-term clinical outcomes
    Toshitaka Naganawa
    Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, Gifu, Japan
    Yonsei Med J 52:121-9. 2011
    ..The present study was performed to evaluate the clinical outcomes, including spinal sagittal alignment of patients, associated with spinal cord tumors treated by surgical excision using hemilaminectomy...
  18. ncbi Management of spinal meningiomas: surgical results and a review of the literature
    Matthias Setzer
    Neurosurgical Clinic, Neurocenter, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Neurosurg Focus 23:E14. 2007
    ..In this report, the authors describe their experience in the surgical management of spinal meningiomas at two neurosurgical centers. The results of a literature review are also presented...
  19. ncbi Recurrence of benign spinal neoplasms
    U Schick
    Clinic of Neurological Surgery, University of Leipzig, Germany
    Neurosurg Rev 24:20-5. 2001
    ..Benign tumours recur in 10.2% of cases, thus requiring long-term follow-up. Magnetic resonance imaging (MRI) studies are recommended up to 5 years postoperatively as a routine procedure...
  20. ncbi Extramedullary intradural spinal tumors: a pictorial review
    Douglas P Beall
    Department of Radiological Sciences, University of Oklahoma Health Science Center, Oklahoma City, OK 73103, USA
    Curr Probl Diagn Radiol 36:185-98. 2007
    ..We discuss imaging features that are typical for the various entities and describe various therapeutic options that are important considerations for surgical treatment of these lesions...
  21. ncbi Glioblastoma with spinal seeding
    Negar Fakhrai
    Clinical Division of Oncology, Department of Medicine I, University of Vienna, Austria
    Strahlenther Onkol 180:455-7. 2004
    ..This case report describes two patients suffering from GBM with spinal seeding. In both cases, the anatomic localization of the primary tumor close to the cerebrospinal fluid (CSF) was the main factor for spinal seeding...
  22. ncbi Stereotactic radiosurgery yields long-term control for benign intradural, extramedullary spinal tumors
    Sean Sachdev
    Department of Radiation Oncology, Stanford University Cancer Center, Stanford, California, USA
    Neurosurgery 69:533-9; discussion 539. 2011
    ..Although a growing body of evidence supports its role in the treatment of malignant spinal lesions, a much less extensive dataset exists for treatment of benign spinal tumors...
  23. ncbi Spinal meningiomas in patients younger than 50 years of age: a 21-year experience
    Aaron A Cohen-Gadol
    Department of Neurologic Surgery, Mayo Medical School, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
    J Neurosurg 98:258-63. 2003
    ..Spinal meningiomas occurring in younger patients may be more aggressive, with a worse prognosis. The authors present their 21-year experience with spinal meningiomas in patients younger than 50 years of age...
  24. ncbi Unilateral partial hemilaminectomy in the removal of a large spinal ependymoma
    Naci Balak
    Department of Neurosurgery, Bakirkoy Dr Sadi Konuk Education and Research Hospital, Istanbul, Turkey
    Spine J 8:1030-6. 2008
    ..Although the hemilaminectomy technique is known to neurosurgeons performing spinal surgery, laminectomy traditionally has been used during spinal canal surgery for extirpation of spinal cord tumors...
  25. ncbi Surgical management of ventral intradural spinal lesions
    Peter D Angevine
    Columbia University College of Physicians and Surgeons, Department of Neurological Surgery, New York, New York, USA
    J Neurosurg Spine 15:28-37. 2011
    ..In this study, the authors review their experience with 35 consecutive cases of ventral intradural spinal lesions...
  26. ncbi Part I: spinal-cord neoplasms-intradural neoplasms
    David E Traul
    Department of Neurology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Lancet Oncol 8:35-45. 2007
    ..In this Review, we discuss the published work on intradural spinal-cord tumours in terms of epidemiological, radiographic, and histological characteristics. Surgical and adjuvant treatment strategies are also reviewed...
  27. ncbi The transspinous mini-open approach for resection of intradural spinal neoplasms: cadaveric feasibility study and report of 3 clinical cases
    Daniel C Lu
    Department of Neurological Surgery, University of California, Los Angeles, California, USA
    World Neurosurg 74:195-9. 2010
    ..Here, we demonstrate the feasibility and initial clinical experience with a new minimally invasive approach for resection of intradural tumors...
  28. ncbi Cases of glioblastoma multiforme metastasizing to spinal cord
    Metehan Karaca
    Department of Radiation Oncology, Ankara University Faculty of Medicine, Cebeci Hospital, Dikimevi Ankara, Turkey
    Neurol India 54:428-30. 2006
    ..Leptomeningeal metastasis and dissemination were diagnosed with magnetic resonance imaging. Radiotherapy provided only temporary relief from pain with small improvement in neurological deficit but no survival advantage...
  29. ncbi A novel intravertebral tumor model in rabbits
    Eric Amundson
    Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Neurosurgery 57:341-6; discussion 341-6. 2005
    ....
  30. ncbi Surgical experience of 120 patients with lumbosacral lipomas
    H Arai
    Department of Neurosurgery, Juntendo University, Tokyo, Japan
    Acta Neurochir (Wien) 143:857-64. 2001
    ..Concerning prophylactic surgery for asymptomatic patients, the former group of patients are obviously good candidates, but the latter group is not...
  31. ncbi Surgical outcome of a posterior approach for large ventral intradural extramedullary spinal cord tumors
    Chi Heon Kim
    Department of Neurosurgery, Seoul National University Hospital, Seoul, South Korea
    Spine (Phila Pa 1976) 36:E531-7. 2011
    ..Case series...
  32. ncbi Impact of tumor histology on resectability and neurological outcome in primary intramedullary spinal cord tumors: a single-center experience with 102 patients
    Isaac O Karikari
    Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neurosurgery 68:188-97; discussion 197. 2011
    ..Surgical outcomes for intramedullary spinal cord tumors are affected by many variables including tumor histology and preoperative neurological function...
  33. ncbi Spinal cord compression in metastatic prostate cancer
    H Tazi
    Service d Urologie, Centre Hospitalier Universitaire Pontchaillou, Rue Henri Le, Guilloux, 35033 cedex, Rennes, France
    Eur Urol 44:527-32. 2003
    ..Spinal cord compression (SCC) in metastatic prostate cancer is not rare occurring in 1 to 12% of patients. We have analysed patients treated for this condition in our institution assessing outcome and prognostic factors...
  34. ncbi Evaluation of functional outcome and local control after radiotherapy for metastatic spinal cord compression in patients with prostate cancer
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Urol 175:552-6. 2006
    ..This study investigates prognostic factors and radiation schedules for functional outcome and local control of MSCC after radiotherapy in patients with prostate cancer...
  35. ncbi Intradural disc mimicking: a spinal tumor lesion
    M V Aydin
    Department of Neurosurgery, Baskent University Medical School, Turkey
    Spinal Cord 42:52-4. 2004
    ..A case report of intradural disc hernia mimicking an intradural extramedullary spinal tumor lesion in radiological evaluation...
  36. ncbi A population-based study of malignant spinal cord compression in Ontario
    D A Loblaw
    Division of Cancer Care and Epidemiology, Queen s Cancer Research Institute, Queen s University, Kingston Regional Cancer Centre and Kingston General Hospital, Kingston, Ontario, Canada
    Clin Oncol (R Coll Radiol) 15:211-7. 2003
    ..Population-based cohort study...
  37. ncbi Spinal and extracranial metastatic dissemination of malignant glioma
    Wai Hoe Ng
    Department of Neurosurgery, National Neuroscience Institute, Tan Tock Seng, Singapore
    J Clin Neurosci 12:379-82. 2005
    ..The pathophysiology and natural history of this condition is still not fully understood, hence well-designed prospective studies are needed...
  38. ncbi Neurosurgical management of intramedullary spinal cord tumors in children
    Karl F Kothbauer
    Division of Neurosurgery, Department of Surgery, Kantonsspital Luzern, Postfach, Luzern, Switzerland
    Pediatr Neurosurg 43:222-35. 2007
    ..g. lasers and intraoperative neurophysiological monitoring with motor evoked potentials. High-grade tumors are resected conservatively and treated with radiation and chemotherapy. The prognosis of high-grade glial tumors remains poor...
  39. ncbi Intramedullary spinal cord metastases: diagnosis and treatment - an illustrated review
    M Kalayci
    Department of Neurosurgery, Zonguldak Karaelmas University Medical School, Zonguldak, Turkey
    Acta Neurochir (Wien) 146:1347-54; discussion 1354. 2004
    ..Optimum treatment remains controversial. On the basis of a review of previous reports and experience with a patient with an ISCM from a large cell lung cancer, we propose practical diagnostic and therapeutic approaches...
  40. ncbi Surgical pathology of spinal schwannomas: a light and electron microscopic analysis of tumor capsules
    M Hasegawa
    Department of Neurosurgery, Kanazawa University School of Medicine, Kanazawa, Japan
    Neurosurgery 49:1388-92; discussion 1392-3. 2001
    ..Although spinal schwannomas are often encountered, the pathology of the tumor capsule has not been reported. In this study, we describe the ultrastructural pathology of the tumor capsule of spinal schwannomas...
  41. ncbi Clinical characteristics of spinal nerve sheath tumors: analysis of 149 cases
    Takahiro Jinnai
    Department of Neurosurgery, Ohtsu Municipal Hospital, Ohtsu, Japan
    Neurosurgery 56:510-5; discussion 510-5. 2005
    ..This article describes the growth pattern of a spinal nerve sheath tumor along the spinal nerve root at various spinal levels...
  42. ncbi Surgical management of spinal cord hemangioblastomas in patients with von Hippel-Lindau disease
    Russell R Lonser
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 98:106-16. 2003
    ....
  43. ncbi MR imaging of a case of a dumbbell-shaped spinal schwannoma with intramedullary and intradural-extramedullary components
    K Kono
    Department of Radiology, Izumi Municipal Hospital, Isumi-shi, Japan
    Neuroradiology 43:864-7. 2001
    ..Before surgery, the tumor was clearly revealed as a mass with two components, intramedullary and extramedullary, on MRI, and it could be useful for operation. We discuss the possible pathogenesis of this tumor...
  44. ncbi The high incidence of tumor dissemination in myxopapillary ependymoma in pediatric patients. Report of five cases and review of the literature
    Daniel R Fassett
    Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah 84113, USA
    J Neurosurg 102:59-64. 2005
    ..In pediatric patients MPEs may spread throughout the CNS via cerebrospinal fluid pathways; therefore, MR imaging of the entire CNS axis is recommended at both presentation and follow-up review to detect tumor dissemination...
  45. ncbi Magnetic resonance imaging of intramedullary spinal cord schwannomas. Report of two cases and review of the literature
    Cesare Colosimo
    Department of Clinical Sciences and Bioimaging, Neuroradiology Section, Institute of Advanced Biomedical Technology, Gabriele d Annunzio University of Chieti, School of Medicine, Chieti, Scalo, Italy
    J Neurosurg 99:114-7. 2003
    ..In cases in which an associated thickened Gd-enhancing spinal nerve root is seen the diagnosis of schwannoma should be assumed...
  46. ncbi [Prognostic factors in the treatment of the intradural extramedullary tumors: a study of 44 cases]
    Daniel Monte Serrat Prevedello
    Departamento de Neurocirurgia, Hospital Nossa Senhora das Gracas, Brasil
    Arq Neuropsiquiatr 61:241-7. 2003
    ..Total resection is the ideal modality of surgical treatment. However, at the thoracic level, where the peculiarities of spine irrigation prevail, surgical morbidade may be higher (p=0.014)...
  47. ncbi Glioblastoma multiforme of the conus medullaris in a child: description of a case and literature review
    Alessandro Stecco
    SCDU Radiologia, AO Maggiore della Carità, Novara, Italy
    AJNR Am J Neuroradiol 26:2157-60. 2005
    ..Nine months after the surgical treatment, the patient showed leptomeningeal recurrence. This case appears to be unusual for both the hysto-type and the nonspecific MR imaging features...
  48. pmc Pediatric spinal cord tumors and masses
    Pamela E Wilson
    Department of Physical Medicine and Rehabilitation, B285, The Children s Hospital, 1056 E 19th Avenue, Denver, Colorado 80218, USA
    J Spinal Cord Med 30:S15-20. 2007
    ..This study presents detailed information regarding clinical presentation, histological findings, outcomes, functional assessment, and management of a series of patients with this diagnosis...
  49. ncbi Long term outcome with post-operative radiation therapy for spinal canal ependymoma
    Sasha H Wahab
    Department of Radiation Oncology, Washington University School of Medicine, 4921 Parkview Place, Lower Level, St Louis, MO 63110, USA
    J Neurooncol 83:85-9. 2007
    ..A retrospective study was performed to evaluate the long term efficacy and safety of post-operative radiation therapy in the management of spinal canal ependymoma at our institution...
  50. ncbi The natural history of hemangioblastomas of the central nervous system in patients with von Hippel-Lindau disease
    John E Wanebo
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 98:82-94. 2003
    ....
  51. ncbi Imaging features and treatment of an intradural lumbar cystic schwannoma
    Guilherme Borges
    Neurology and Neurosurgery Department, State University of Campinas UNICAMP, Campinas, SP, Brazil
    Arq Neuropsiquiatr 63:681-4. 2005
    ..The patient presented with complete recovery of his symptom. In this article we aim to emphasize the clinical presentation and treatment of lumbar spine schwannomas, and to illustrate the imaging findings within this uncommon case...
  52. ncbi Outcome following decompressive surgery for different histological types of metastatic tumors causing epidural spinal cord compression. Clinical article
    Kaisorn L Chaichana
    Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Neurosurg Spine 11:56-63. 2009
    ..The differential outcomes for patients with different histological types of metastatic disease therefore remain unknown...
  53. ncbi MR findings in spinal hemangioblastoma: correlation with symptoms and with angiographic and surgical findings
    B C Chu
    Department of Radiology, Hokkaido University School of Medicine, Sapporo, Japan
    AJNR Am J Neuroradiol 22:206-17. 2001
    ..CONCLUSION: Knowledge of these MR features helps to differentiate spinal hemangioblastoma from other diseases that show enhancing nodules...
  54. ncbi Resection of thoracic dumbbell neurinomas: single postero-lateral approach or combined posterior and transthoracic approach?
    M Payer
    Department of Neurosurgery, University Hospital of Geneva, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    J Clin Neurosci 13:690-3. 2006
    ..We report the removal of a dumbbell neurinoma at T6/7 using a single posterior midline approach with laminectomy and costo-transversectomy and review the literature regarding the approaches to thoracic dumbbell tumours...
  55. ncbi Intramedullary and spinal canal tumors in patients with neurofibromatosis 2: MR imaging findings and correlation with genotype
    N J Patronas
    Department of Diagnostic Radiology, Clinical Center, National Institutes of Health, 10 Center Dr, MSC 1182, Rm 1C660, Bethesda, MD 20892 1182, USA
    Radiology 218:434-42. 2001
    ....
  56. ncbi Results after surgery for lumbosacral lipoma: the significance of early and late worsening
    F van Calenbergh
    Department of Neurosurgery, University Hospital Gasthuisberg, Catholic University, Herestraat 49, B 3000 Leuven, Belgium
    Childs Nerv Syst 15:439-42; discussion 443. 1999
    ..This can be interpreted as an argument against prophylactic surgery in asymptomatic patients...
  57. ncbi Pediatric intramedullary spinal cord tumors
    Kurtis I Auguste
    Department of Neurological Surgery, University of California, San Francisco, CA 94143 0112, USA
    Neurosurg Clin N Am 17:51-61. 2006
  58. ncbi Spinal hemangioblastoma containing metastatic renal cell carcinoma in von Hippel-Lindau disease. Case report and review of the literature
    Meric A Altinoz
    Department of Neurosurgery, Brain Tumour Research Center, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
    J Neurosurg Spine 3:495-500. 2005
    ..A review of the literature revealed that RCC-to-CNS hemangioblastoma is the second most common donor-recipient tumor association among the tumor-to-tumor metastases...
  59. ncbi Postoperative changes of spinal curvature and range of motion in adult patients with cervical spinal cord tumors: analysis of 51 cases and review of the literature
    Takashi Asazuma
    Department of Orthopaedic Surgery, National Defense Medical College, Saitama, Japan
    J Spinal Disord Tech 17:178-82. 2004
    ..We sought to determine factors likely to influence postoperative changes in cervical spinal curvature and range of motion (ROM) in patients with cervical spinal cord tumors...
  60. ncbi Intramedullary spinal tumors of disordered embryogenesis
    K Muraszko
    Department of Pediatric Neurosurgery, University of Michigan, Ann Arbor 48109 0339, USA
    J Neurooncol 47:271-81. 2000
    ..Proper surgical management of these various conditions necessitates a thorough understanding of their embryologic etiology and the anatomic/physiologic ramifications that such lesions have on the developing spinal cord...
  61. ncbi Neurofibromatosis 2 in the pediatric population
    Fabio Nunes
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Child Neurol 18:718-24. 2003
    ..Further work is needed to determine optimal management of pediatric neurofibromatosis 2...
  62. ncbi Neurofibromatosis type 2 diagnosed in the absence of vestibular schwannomas. A case report and guidelines for a screening protocol for children at risk
    A J Janse
    Department of Paediatrics, Wilhelmina Children's Hospital, Utrecht, The Netherlands
    Eur J Pediatr 160:439-43. 2001
    ..In these cases molecular studies may provide additional evidence for the diagnosis. We propose guidelines for a screening protocol for children at risk for having neurofibromatosis type 2...
  63. ncbi Intramedullary spinal cord tumors in children
    George I Jallo
    Division of Pediatric Neurosurgery, Johns Hopkins Hospital, 600 North Wolfe Street, Harvey 811, Baltimore, MD 21287, USA
    Childs Nerv Syst 19:641-9. 2003
    ..Pediatric intramedullary spinal cord tumors are rare and make up only a small percentage of all central nervous system neoplasms...
  64. ncbi Metastases to hemangioblastomas in von Hippel-Lindau disease
    S Taylor Jarrell
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 105:256-63. 2006
    ....
  65. ncbi Spinal cord astrocytomas: presentation, management, and outcome
    Chan Roonprapunt
    Department of Neurosurgery, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030, USA
    Neurosurg Clin N Am 17:29-36. 2006
  66. ncbi Role of surgery for maintaining urological function and prevention of retethering in the treatment of lipomeningomyelocele: experience recorded in 75 lipomeningomyelocele patients
    Joon Ki Kang
    Department of Neurosurgery, Kangnam St Mary s Hospital, College of Medicine, The Catholic University of Korea, 505 Banpo dong Seocho gu, Seoul 137 040, Korea
    Childs Nerv Syst 19:23-9. 2003
    ....
  67. ncbi Surgical management of isolated hemangioblastomas of the spinal cord
    C Roonprapunt
    Division of Pediatric Neurosurgery, Institute for Neurology and Neurosurgery, Beth Israel Medical Center, New York, New York 10128, USA
    Neurosurgery 49:321-7; discussion 327-8. 2001
    ..These tumors have characteristic imaging properties on magnetic resonance imaging and angiography. Surgical removal of these lesions results in excellent long-term functional outcome...
  68. pmc Chromosomal abnormalities subdivide ependymal tumors into clinically relevant groups
    Y Hirose
    Department of Neurological Surgery, University of California, San Francisco, CA 91943-0808, USA
    Am J Pathol 158:1137-43. 2001
    ..We conclude that cytogenetic analysis of ependymomas may help to classify these tumors and provide leads concerning their initiation and progression. The relationship of these aberrations to patient outcome needs to be addressed...
  69. ncbi Solitary fibrous tumor of the spinal cord: a clinicopathologic study of two cases
    Stefano Pizzolitto
    Department of Pathology and Laboratory Medicine, General Hospital S Maria della Misericordia, Udine, Italy
    Ann Diagn Pathol 8:268-75. 2004
    ....
  70. ncbi Clear cell ependymoma with a lipidized component that developed in the thoracic spinal cord
    Yeong Jin Kim
    Department of Neurosurgery, Higashiosaka City General Hospital, 3 4 5 Nishiiwata cho, Higashiosaka 578 8588, Japan
    Neurol Res 25:324-8. 2003
    ..The MIB-1 staining index was 0.25%. Based on these findings, diagnosis of clear cell ependymoma with a lipidized component was made...
  71. ncbi Intramedullary spinal cord tumors in patients older than 50 years of age: management and outcome analysis
    Raj K Shrivastava
    Department of Neurosurgery, St Luke s Roosevelt Hospital Center, New York, New York, USA
    J Neurosurg Spine 2:249-55. 2005
    ..The authors examined their IMSCT database and report the first large series of IMSCTs in patients older than 50 years of age...
  72. ncbi Neurological outcome after resection of intramedullary spinal cord tumors in children
    Matthew J McGirt
    Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Childs Nerv Syst 24:93-7. 2008
    ..Clinical and radiographic risk factors predictive of postoperative neurological outcome may serve as a guide for surgical risk stratification...
  73. ncbi Torticollis secondary to posterior fossa and cervical spinal cord tumors: report of five cases and literature review
    Sefer Kumandas
    Department of Pediatric Neurology, Erciyes University Medical School, Kayseri, Turkey
    Neurosurg Rev 29:333-8; discussion 338. 2006
    ..Although torticollis secondary to tumors is rarely seen, it is necessary to be kept in mind in the differential diagnosis...
  74. ncbi The natural history of conservatively managed symptomatic intramedullary spinal cord cavernomas
    Siddharth Kharkar
    Neurosurgery 60:865-72; discussion 865-72. 2007
    ..The objective is to provide additional information regarding the natural history of conservatively managed, symptomatic, intramedullary spinal cord cavernous malformations...
  75. pmc Gene expression patterns in ependymomas correlate with tumor location, grade, and patient age
    Andrey Korshunov
    Department of Neuropathology, Neurosurgical Nikolai Nilovich Burdenko Institute, Moscow, Russia
    Am J Pathol 163:1721-7. 2003
    ..In summary, our results provide new insight in the biochemical pathways particularly intriguing in the pathomechanism of ependymomas and suggest that this entity comprises molecularly distinct diseases...
  76. ncbi Radical excision of intramedullary spinal cord tumors: surgical morbidity and long-term follow-up evaluation in 164 children and young adults
    S Constantini
    Institute for Neurology and Neurosurgery, Beth Israel Medical Center, New York, New York, USA
    J Neurosurg 93:183-93. 2000
    ..In an attempt to resolve this controversy, the long-term morbidity and survival in a large series of children have been retrospectively reviewed...
  77. ncbi Tumors of the spine in children
    Andrea Rossi
    Department of Pediatric Neuroradiology, G Gaslini Children s Hospital, Largo G Gaslini 5, I 16147 Genoa, Italy
    Neuroimaging Clin N Am 17:17-35. 2007
    ..Magnetic resonance imaging provides crucial information regarding the extent, location, and internal structure of the mass, thus critically narrowing the differential diagnosis and guiding surgery...
  78. ncbi Intramedullary cavernous angioma of the spinal cord in a pediatric patient, with multiple cavernomas, familial occurrence and partial spontaneous regression: case report and review of the literature
    Antonio Santoro
    Department of Neurological Sciences Neurosurgery, University of Rome La Sapienza, Neurochirurgia1, Viale del Policlinico, 155, 00185 Rome, Italy
    Childs Nerv Syst 23:1319-26. 2007
    ..The authors present their experience with the 17th pediatric intramedullary cavernoma reported in English literature...
  79. ncbi Low back pain and sciatica as the presenting symptoms of neurinoma near the conus medullaris. Contribution of magnetic resonance imaging
    Latifa Harzallah
    Joint Bone Spine 72:187-9. 2005
  80. ncbi Solitary fibrous tumor of the spinal nerve rootlet: report of a case mimicking schwannoma
    Simonetta Piana
    Servizio di Anatomia ed Istologia Patologica, Ospedale Santa Maria Nuova, Reggio Emilia, Italy
    Arch Pathol Lab Med 128:335-7. 2004
    ..The present case suggests that solitary fibrous tumor should be considered in differentiating spindle cell lesions of the spinal cord and nerve rootlet...
  81. ncbi Analysis of chromosome 7 in adult and pediatric ependymomas using chromogenic in situ hybridization
    Mariarita Santi
    Department of Pathology, Children s Hospital National Medical Center, Washington, DC, USA
    J Neurooncol 72:25-8. 2005
    ..These results encourage further investigations with CISH on a larger scale to determine its merit as an ancillary diagnostic and prognostic tool...
  82. ncbi Solitary fibrous tumor of the spinal cord: case report and review of the literature
    Mitsuhiro Kawamura
    Department of Orthopedic Surgery, Osaka Seamen s Insurance Hospital, Osaka, Japan
    Neurosurgery 55:433. 2004
  83. ncbi Intramedullary spinal cord ependymomas in children: treatment, results and follow-up
    M Lonjon
    Service de Neurochirurgie, Hopital Pasteur, Nice, France
    Pediatr Neurosurg 29:178-83. 1998
    ..We conclude that a complete removal can be achieved in almost all cases of intramedullary spinal cord ependymomas in children, and that the long survival rates justify avoiding post-operative radiation therapy...
  84. ncbi Spinal cord gangliogliomas: a review of 56 patients
    George I Jallo
    Johns Hopkins University School of Medicine, Division of Pediatric Neurosurgery, Baltimore, MD, USA
    J Neurooncol 68:71-7. 2004
    ..Patients have a long survival following radical surgery. These tumors have an indolent course, and radiotherapy appears to be unnecessary...
  85. ncbi The results of radiotherapy for ependymomas: the Mayo Clinic experience
    S E Schild
    Mayo Clinic Arizona, Department of Radiation Oncology, Scottsdale 85259, USA
    Int J Radiat Oncol Biol Phys 42:953-8. 1998
    ..This analysis was performed to examine the outcome of patients with histologically confirmed ependymomas of the brain or spinal cord who received postoperative radiotherapy...
  86. ncbi Recurrent spinal ependymoma showing partial remission under Imatimib
    N Fakhrai
    Department of Medicine I, Clinical Division of Oncology, University of Vienna, Vienna, Austria
    Acta Neurochir (Wien) 146:1255-8. 2004
    ..There are few treatment options for recurrent spinal ependymoma after surgery and radiation therapy...
  87. ncbi Solitary fibrous tumour of the spinal cord
    J P Mordani
    Department of Radiology, City General Hospital, Stoke on Trent, UK
    Neuroradiology 42:679-81. 2000
    ..The tumour predominantly consisted of monomorphic spindle cells with a storiform pattern. MRI demonstrated an inhomogeneously enhancing cervical intramedullary tumour. The patient was well without recurrence 18 months after surgery...
  88. ncbi [Nocturnal back pain; a misdiagnosed symptom of spinal tumor]
    R J Groen
    Slotervaart Ziekenhuis, afd Neurochirurgie, Louwesweg 6, 1066 EC Amsterdam
    Ned Tijdschr Geneeskd 145:2134-8. 2001
    ..The importance of recognising these early complaints is stressed. Nowadays, MRI is the technique of choice to answer the question whether there is a space occupying process in the spine...
  89. ncbi Spinal tumors in children
    Mandy Binning
    Department of Neurosurgery, University of Utah, 175 N Medical Drive East, 3B 409 SOM, Salt Lake City, UT 84132 2303, USA
    Neurosurg Clin N Am 18:631-58. 2007
    ..Rather, the key clinical, diagnostic, and therapeutic features of each tumor are discussed...
  90. ncbi Cervical intra-/extramedullary solitary fibrous tumour
    B Ogungbo
    Department of Neurosurgery, James Cook University Hospital, Middlesbrough, UK
    Br J Neurosurg 19:254-7. 2005
    ..The final histology was a solitary fibrous tumour (SFT) of the cervical spinal cord. The radiological diagnosis, surgical management and histology are reviewed...
  91. ncbi [A rare cause of sciatica]
    T Amezyane
    Clinique Medicale, HIA Val de Grace, 00446 ARMEES cedex, France
    Rev Med Interne 27:494-6. 2006
  92. ncbi The clinical and surgical aspects of spinal tumors in children
    Alper Baysefer
    Department of Neurosurgery, School of Medicine, Gulhane Military Medical Academy, Ankara, Turkey
    Pediatr Neurol 31:261-6. 2004
    ..Laminotomy was the main surgical method in 60% of the patients with spinal tumor, especially in children younger than 3 years of age...
  93. ncbi Outcome in 53 patients with spinal cord cavernomas
    Pierre Labauge
    Service de Neurologie, CHU de Nimes, 30029 France
    Surg Neurol 70:176-81; discussion 181. 2008
    ..Prevalence of cerebral cavernomas in the general population is close to 0.5%. In contrast, SCCs are rare. The aim of this study was to determine the outcome of SCC in a large sample of patients...
  94. ncbi Enlargement of the spinal cord: inflammation or neoplasm?
    Marko Brinar
    University Department of Internal Medicine, Zagreb School of Medicine and University Hospital Center, Kispaticeva 12, Zagreb, Croatia
    Clin Neurol Neurosurg 108:284-9. 2006
    ....
  95. ncbi Intramedullary cavernous angiomas of the spinal cord in the pediatric age group: a pediatric series
    Mahmoud G Nagib
    Neurosurgical Associates Ltd, Minneapolis, MN 55407, USA
    Pediatr Neurosurg 36:57-63. 2002
    ..MRI of the entire neuraxis is recommended for lesion multiplicity. An attempt at total resection and long-term MRI follow-up are recommended...
  96. ncbi Extent of surgical resection of malignant astrocytomas of the spinal cord: outcome analysis of 35 patients
    Matthew J McGirt
    Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, Maryland 21218, USA
    Neurosurgery 63:55-60; discussion 60-1. 2008
    ..We report the outcomes of the surgical management of 35 malignant spinal cord astrocytomas and assess the association of extent of resection with survival after aggressive resection of these tumors...
  97. ncbi Long term outcomes following surgical resection of myxopapillary ependymomas
    Carlos A Bagley
    Division of Neurosurgery, Duke University School of Medicine, Durham, NC, USA
    Neurosurg Rev 32:321-34; discussion 334. 2009
    ..Excellent outcomes may be obtained, however, with the use of aggressive surgical techniques. No clear benefit for adjunctive chemotherapy, and radiation therapy was demonstrated...
  98. ncbi Ependymomas
    Marc C Chamberlain
    Department of Neurology, USC Norris Cancer Center, 1441 Eastlake Avenue, Suite 3459, Los Angeles, CA 90033 0804, USA
    Curr Neurol Neurosci Rep 3:193-9. 2003
    ..Disease-free survival following recurrence is unusual (<15% at 5 years) and suggests intensification of initial adjuvant treatment may best prevent relapse...
  99. ncbi Intramedullary spinal cord cavernous malformations: clinical features and risk of hemorrhage
    Ibrahim Erol Sandalcioglu
    Department of Neurosurgery, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Neurosurg Rev 26:253-6. 2003
    ..Based on the significant risk of rehemorrhage and the gratifying functional results, surgery is indicated for symptomatic IMSC cavernous malformations...
  100. ncbi Pediatric intramedullary spinal cavernous malformations
    H Deutsch
    Institute for Neurology and Neurosurgery, Beth Israel Medical Center, New York, New York 10128, USA
    Spine (Phila Pa 1976) 26:E427-31. 2001
    ..CONCLUSIONS: The surgical removal of these malformations results in a good functional outcome. The entire neuraxis should be screened because there is a high incidence of multiple lesions...
  101. ncbi Pediatric low-grade and ependymal spinal cord tumors
    T E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Pediatr Neurosurg 32:30-6. 2000
    ..Patients with disseminated EP, MPEP, JPA and nonpilocytic astrocytoma may achieve long-term progression-free survival with craniospinal irradiation...

Research Grants20

  1. TARGETED THERAPY FOR CHEMORESISTANT TUMORS
    Nina Schor; Fiscal Year: 2006
    ..Ultimately, this predictive panel will help to identify those patients whose chemoresistant tumors are likely to be particularly sensitive to enediyne treatment. [unreadable] [unreadable]..
  2. NEUROTROPHIC MECHANISMS IN NEUROBLASTOMA
    Nina Schor; Fiscal Year: 2008
    ..abstract_text> ..
  3. Polysomal RNA Antitumor Immunity
    John Chi; Fiscal Year: 2005
    ..Results from these experiments will help characterize the potential use of dendritic cells transfected with polysomal RNA in creating antigen specific tumor vaccines for brain tumors. ..
  4. NEURODEVELOPMENTAL AND NEURODEGERENTATIVE DISEASE
    Nina Schor; Fiscal Year: 2005
    ..Funding of this program will perpetuate this history at an economically and academically critical time. ..
  5. Antioxidant Strategies for Parkinson's Disease
    Nina Schor; Fiscal Year: 2005
    ..abstract_text> ..
  6. Spatial-Temporal Imaging of Cell Proliferation & Hypoxia
    Robert Jeraj; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  7. Lapatinib in childhood CNS malignancies
    Maryam Fouladi; Fiscal Year: 2006
    ..These data will be used in the rational design of future phase I combination or frontline studies to improve the outcome in children with these poor prognosis tumors. [unreadable] [unreadable]..
  8. EARLY GENETIC EVENTS IN ASTROCYTOMA FORMATION
    JOHN HENSON; Fiscal Year: 2003
    ..As a way forward to new hypotheses, they will determine genome-wide changes in subsets of LGA patients with good and poor outcomes using comparative genomic hybridization (CGH). ..
  9. HIV and the Proteasome in the Aging Human Brain
    Benjamin Gelman; Fiscal Year: 2005
    ..The linkage between brain inflammation and altered neuronal protein turnover could lead to a unifying functional concept of dementia with application to HIV and aging both. ..
  10. Dopamine Systems and Neuropsychiatric Changes in HIV/AIDS
    Benjamin B Gelman; Fiscal Year: 2010
    ..The project breaks ground neuroscientifically, as no autopsy study has advanced to a "task specific" behavioral correlation with circuit level anomalies of a specific neurotransmitter system. ..
  11. MYELOPATHY AND NEUROPATHY DURING CHANGING HIV BURDEN
    Benjamin Gelman; Fiscal Year: 2004
    ..Together, the studies we have proposed will provide insights concerning prevalent AIDS morbidities in the HAART era. ..
  12. Indomethacin and p38 Regulating AP-1 In Heat Shock
    Jacob Locke; Fiscal Year: 2004
    ..abstract_text> ..
  13. Gene Transfer to Facilitate Dose-Intensification in the Treatment of Pediatric B*
    Lars Wagner; Fiscal Year: 2007
    ..We hypothesize this strategy will be well tolerated and allow for meaningful dose escalation through chemoprotection afforded by gene transfer into hematopoietic stem cells. [unreadable] [unreadable] [unreadable]..
  14. TEXAS REPOSITORY FOR AIDS NEUROPATHOGENESIS RESEARCH
    Benjamin Gelman; Fiscal Year: 2007
    ..abstract_text> ..
  15. Regulation- Medulloblastoma Growth by alpha-v integrins
    Tobey Macdonald; Fiscal Year: 2006
    ..The long-range goal of this work is to broaden our understanding of medulloblastoma growth, so that novel biologic therapies may be developed into new treatments for medulloblastoma, the most common malignant brain tumor in children. ..
  16. Antigen specific modeling of glioma immunotherapy
    Andrew Parsa; Fiscal Year: 2007
    ..The long-term goal of this proposal is to facilitate the development of Dr. Parsa into an independent investigator capable of making meaningful scientific contributions. ..
  17. Inhibition of the PI3 Kinase Pathway in Malignant Glioma by Convection Enhanced D
    James Waldron; Fiscal Year: 2007
    ..Demonstration of improved outcomes with combination therapy will support the development of human clinical trials using specific pathway inhibition to improve response to immunotherapy. [unreadable] [unreadable] [unreadable]..
  18. BODY WEIGHT SUPPORTED AMBULATION TRAINING AFTER SCI
    Blair Calancie; Fiscal Year: 2004
    ..abstract_text> ..
  19. SPINAL MOTOR CONDUCTION AND RECOVERY AFTER HUMAN SCI
    Blair Calancie; Fiscal Year: 2009
    ..A slow-release formulation the K-channel blocker 4-aminopyridine will be tested for its effects on conduction in some cases. ..
  20. PRE-CLINICAL STUDIES OF SPINAL-CORD INJURY REPAIR
    Nurit Kalderon; Fiscal Year: 2004
    ..g., dose protocol) at which repair is facilitated. Analysis of repair is conducted using magnetic resonance imaging of the lesion site at the cord, quantitative histologic and electrophysiologic methods and behavioral methods. ..