spinal cord compression

Summary

Summary: Acute and chronic conditions characterized by external mechanical compression of the SPINAL CORD due to extramedullary neoplasm; EPIDURAL ABSCESS; SPINAL FRACTURES; bony deformities of the vertebral bodies; and other conditions. Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence.

Top Publications

  1. ncbi Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial
    Roy A Patchell
    Department of Surgery Neurosurgery, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Lancet 366:643-8. 2005
  2. ncbi Laminectomy and posterior cervical plating for multilevel cervical spondylotic myelopathy and ossification of the posterior longitudinal ligament: effects on cervical alignment, spinal cord compression, and neurological outcome
    John K Houten
    Department of Neurosurgery, New York University School of Medicine, New York, New York 10016, USA
    Neurosurgery 52:1081-7; discussion 1087-8. 2003
  3. ncbi Molecular mechanisms of spinal cord dysfunction and cell death in the spinal hyperostotic mouse: implications for the pathophysiology of human cervical spondylotic myelopathy
    Wen Ru Yu
    Division of Genetics and Development, Toronto Western Research Institute and Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Neurobiol Dis 33:149-63. 2009
  4. ncbi Prognostic factors for local control and survival after radiotherapy of metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Germany
    J Clin Oncol 24:3388-93. 2006
  5. pmc A re-assessment of erythropoietin as a neuroprotective agent following rat spinal cord compression or contusion injury
    Alberto Pinzon
    Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Exp Neurol 213:129-36. 2008
  6. ncbi A review of the pathophysiology of cervical spondylotic myelopathy with insights for potential novel mechanisms drawn from traumatic spinal cord injury
    M G Fehlings
    Division of Neurosurgery, Toronto Hospital, University of Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 23:2730-7. 1998
  7. ncbi The acute administration of eicosapentaenoic acid is neuroprotective after spinal cord compression injury in rats
    Siew Na Lim
    Centre for Neuroscience and Trauma, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London, UK
    Prostaglandins Leukot Essent Fatty Acids 83:193-201. 2010
  8. ncbi A model for acute, chronic, and delayed graded compression of the dog cauda equina. Presentation of the gross, microscopic, and vascular anatomy of the dog cauda equina and accuracy in pressure transmission of the compression model
    S Konno
    Department of Orthopedic Surgery, Fukushima Medical College, Japan
    Spine (Phila Pa 1976) 20:2758-64. 1995
  9. ncbi Animal models used in spinal cord regeneration research
    Brian K Kwon
    Collaboration on Repair Discoveries, University of British Columbia, Vancouver, Canada
    Spine (Phila Pa 1976) 27:1504-10. 2002
  10. pmc Spinal cord compression in breast cancer: a review of 70 cases
    M E Hill
    ICRF Clinical Oncology Unit, Guy s Hospital, London, UK
    Br J Cancer 68:969-73. 1993

Detail Information

Publications338 found, 100 shown here

  1. ncbi Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial
    Roy A Patchell
    Department of Surgery Neurosurgery, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Lancet 366:643-8. 2005
    The standard treatment for spinal cord compression caused by metastatic cancer is corticosteroids and radiotherapy. The role of surgery has not been established. We assessed the efficacy of direct decompressive surgery.
  2. ncbi Laminectomy and posterior cervical plating for multilevel cervical spondylotic myelopathy and ossification of the posterior longitudinal ligament: effects on cervical alignment, spinal cord compression, and neurological outcome
    John K Houten
    Department of Neurosurgery, New York University School of Medicine, New York, New York 10016, USA
    Neurosurgery 52:1081-7; discussion 1087-8. 2003
    ....
  3. ncbi Molecular mechanisms of spinal cord dysfunction and cell death in the spinal hyperostotic mouse: implications for the pathophysiology of human cervical spondylotic myelopathy
    Wen Ru Yu
    Division of Genetics and Development, Toronto Western Research Institute and Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Neurobiol Dis 33:149-63. 2009
    ..This study reports novel evidence, which demonstrates that chronic extrinsic cervical spinal cord compression leads to Fas-mediated apoptosis of neurons and oligodendrocytes which is associated with activation of ..
  4. ncbi Prognostic factors for local control and survival after radiotherapy of metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Germany
    J Clin Oncol 24:3388-93. 2006
    To evaluate potential prognostic factors for local control and survival after radiotherapy of metastatic spinal cord compression (MSCC).
  5. pmc A re-assessment of erythropoietin as a neuroprotective agent following rat spinal cord compression or contusion injury
    Alberto Pinzon
    Department of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Exp Neurol 213:129-36. 2008
    ..With these results, although we cannot conclude that there will be no beneficial effect in different SCI models, we caution researchers that the use of rhEPO requires further investigation before implementing clinical trials...
  6. ncbi A review of the pathophysiology of cervical spondylotic myelopathy with insights for potential novel mechanisms drawn from traumatic spinal cord injury
    M G Fehlings
    Division of Neurosurgery, Toronto Hospital, University of Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 23:2730-7. 1998
    ..Fundamental research at a cellular and molecular level, particularly in the areas of glutamatergic toxicity and apoptosis may result in clinically relevant treatments for this condition...
  7. ncbi The acute administration of eicosapentaenoic acid is neuroprotective after spinal cord compression injury in rats
    Siew Na Lim
    Centre for Neuroscience and Trauma, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London, UK
    Prostaglandins Leukot Essent Fatty Acids 83:193-201. 2010
    ..of the present study was to investigate the effects of treatment with eicosapentaenoic acid (EPA) after spinal cord compression injury in adult rats...
  8. ncbi A model for acute, chronic, and delayed graded compression of the dog cauda equina. Presentation of the gross, microscopic, and vascular anatomy of the dog cauda equina and accuracy in pressure transmission of the compression model
    S Konno
    Department of Orthopedic Surgery, Fukushima Medical College, Japan
    Spine (Phila Pa 1976) 20:2758-64. 1995
    ..e., additional compression after a certain time of chronic compression to resemble the changes in pressure that are characteristic for neurogenic claudication...
  9. ncbi Animal models used in spinal cord regeneration research
    Brian K Kwon
    Collaboration on Repair Discoveries, University of British Columbia, Vancouver, Canada
    Spine (Phila Pa 1976) 27:1504-10. 2002
    ..A literature review was conducted...
  10. pmc Spinal cord compression in breast cancer: a review of 70 cases
    M E Hill
    ICRF Clinical Oncology Unit, Guy s Hospital, London, UK
    Br J Cancer 68:969-73. 1993
    b>Spinal cord compression (SCC) is a relatively uncommon but frequently disabling complication of metastatic breast cancer...
  11. pmc Multivariate analysis of the neurological outcome of surgery for cervical compressive myelopathy
    Kenzo Uchida
    Division of Orthopaedics and Rehabilitation Medicine, Department of Surgery, Faculty of Medicine, University of Fukui, 23 Shimoaizuki, Matsuoka, Fukui, 910 1193, Japan
    J Orthop Sci 10:564-73. 2005
    ..We examined the results of multivariate analysis and multiple regression analysis of the neurological outcome of patients treated by cervical cord decompression...
  12. ncbi A population-based study of malignant spinal cord compression in Ontario
    D A Loblaw
    Division of Cancer Care and Epidemiology, Queen s Cancer Research Institute, Queen s University, Kingston Regional Cancer Centre and Kingston General Hospital, Kingston, Ontario, Canada
    Clin Oncol (R Coll Radiol) 15:211-7. 2003
    ..Population-based cohort study...
  13. pmc A meta-analysis of surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease
    Paul Klimo
    Department of Neurosurgery, University of Utah, Salt Lake City, UT 84108, USA
    Neuro Oncol 7:64-76. 2005
    ..Neurologic status, overall health, extent of disease (spinal and extraspinal), and primary pathology all impact proper treatment selection...
  14. ncbi Interobserver and intraobserver reliability of the japanese orthopaedic association scoring system for evaluation of cervical compression myelopathy
    K Yonenobu
    Department of Orthopaedic Surgery, Osaka University Medical School, Suita, Japan
    Spine (Phila Pa 1976) 26:1890-4; discussion 1895. 2001
    ..It evaluates the severity of myelopathy by allocating points based on degree of dysfunction in each category...
  15. ncbi Spinal intradural extramedullary hydatidosis: report of three cases
    Fayçal Lakhdar
    Department of Neurosurgery, Hopital des specialites, Mohamed Vth University School of Medicine, Rabat, Morocco
    Neurosurgery 65:372-6; discussion 376-7. 2009
    ..We report 3 healthy patients who presented with progressive paraparesis attributed to a histologically proven intradural hydatid cyst...
  16. pmc The prevalence and phenotype of activated microglia/macrophages within the spinal cord of the hyperostotic mouse (twy/twy) changes in response to chronic progressive spinal cord compression: implications for human cervical compressive myelopathy
    Takayuki Hirai
    Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Eiheiji, Fukui, Japan
    PLoS ONE 8:e64528. 2013
    ..The present study assessed the localized prevalence of activated M1 and M2 microglia/macrophages in twy/twy mice that develop spontaneous cervical spinal cord compression, as a model of human disease.
  17. ncbi Do elderly patients benefit from surgery in addition to radiotherapy for treatment of metastatic spinal cord compression?
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 188:424-30. 2012
    ..One question regarding the treatment of metastatic spinal cord compression (MSCC) is whether elderly patients benefit from surgery in addition to radiotherapy? In attempting to ..
  18. ncbi Percutaneous translumbar spinal cord compression injury in dogs from an angioplasty balloon: MR and histopathologic changes with balloon sizes and compression times
    Phillip D Purdy
    Department of Radiology, Division of Neuroradiology, the University of Texas Southwestern Medical Center at Dallas 75390 8896, USA
    AJNR Am J Neuroradiol 25:1435-42. 2004
    ..Our previous model of spinal cord injury (SCI) included six dogs undergoing 30-minute compression with a balloon in the subarachnoid space. We determined whether various balloon sizes and compression times creates a gradation of injuries...
  19. ncbi Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    J Clin Oncol 23:3366-75. 2005
    To study five radiotherapy (RT) schedules and potential prognostic factors for functional outcome in metastatic spinal cord compression (MSCC).
  20. ncbi Effects of core body temperature on changes in spinal somatosensory-evoked potential in acute spinal cord compression injury: an experimental study in the rat
    I M Jou
    Department of Orthopedics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    Spine (Phila Pa 1976) 25:1878-85. 2000
    ..Acute spinal cord injury was induced by a clip compression model in rats to approximate spinal cord injury encountered in spinal surgery. Spinal somatosensory-evoked potential neuromonitoring was used to study the electrophysiologic change...
  21. ncbi Cervical laminectomy vs laminoplasty: is there a difference in outcome and postoperative pain?
    Besnik Nurboja
    Department of Neurosurgery, Kings College Hospital, London, United Kingdom
    Neurosurgery 70:965-70; discussion 970. 2012
    ..Cervical laminoplasty is often used for the decompression of multilevel cervical spondylotic myelopathy without creating spinal instability and kyphosis...
  22. ncbi A score predicting posttreatment ambulatory status in patients irradiated for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 72:905-8. 2008
    To create a scoring system to predict ambulatory status after radiotherapy (RT) for metastatic spinal cord compression (MSCC).
  23. ncbi Predicting survival for surgery of metastatic spinal cord compression in prostate cancer: a new score
    Sead Crnalic
    Department of Surgical and Perioperative Sciences Orthopedics, Umea University, Umea, Sweden
    Spine (Phila Pa 1976) 37:2168-76. 2012
    We retrospectively analyzed prognostic factors for survival in patients with prostate cancer operated for metastatic spinal cord compression.
  24. pmc Prognostic factors for different outcomes in patients with metastatic spinal cord compression from cancer of unknown primary
    Sarah Douglas
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    BMC Cancer 12:261. 2012
    Patients with cancer of unknown primary account for 10% of patients with metastatic spinal cord compression (MSCC)...
  25. pmc Establishment of a canine spinal cord injury model induced by epidural balloon compression
    Ji Hey Lim
    Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University, Seoul 151 742, Korea
    J Vet Sci 8:89-94. 2007
    ..5, 0, and 1.7, respectively. Based on these results, a SCO > 50% for 24 h, and > 75% for 12 h induces paraplegia up to a week after spinal cord injury...
  26. pmc Anterior versus posterior surgery for multilevel cervical myelopathy, which one is better? A systematic review
    Tao Liu
    Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, People s Republic of China
    Eur Spine J 20:224-35. 2011
    ..While for OPLL patients with occupying ratio ≥ 60%, anterior surgery had superior clinical outcome to posterior surgery...
  27. ncbi Final results of a prospective study comparing the local control of short-course and long-course radiotherapy for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Int J Radiat Oncol Biol Phys 79:524-30. 2011
    Many patients with metastatic spinal cord compression (MSCC) live long enough to develop a recurrence in the irradiated spinal area...
  28. ncbi Improved outcome after spinal cord compression injury in mice treated with docosahexaenoic acid
    Siew Na Lim
    Centre for Neuroscience and Trauma, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Exp Neurol 239:13-27. 2013
    ..For some of these indices of SCI, enrichment of the diet with 400 mg/kg/day DHA led to further improvement. However, dietary DHA supplementation, without the initial i.v. injection, was ineffective...
  29. ncbi A prospective evaluation of two radiotherapy schedules with 10 versus 20 fractions for the treatment of metastatic spinal cord compression: final results of a multicenter study
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg, Hamburg, Germany
    Cancer 101:2687-92. 2004
    The optimal treatment of patients with metastatic spinal cord compression (MSCC) is still being debated...
  30. ncbi Viscoelastic relaxation and regional blood flow response to spinal cord compression and decompression
    G D Carlson
    University Hospitals Spine Institute, Department of Orthopaedic Surgery, Cleveland, Ohio, USA
    Spine (Phila Pa 1976) 22:1285-91. 1997
    ..METHODS: Twelve beagles were anesthetized and underwent T13 laminectomy. A constant velocity spinal cord compression was applied using a hydraulic loading piston with a subminiature pressure transducer rigidly attached to ..
  31. ncbi Clip compression model is useful for thoracic spinal cord injuries: histologic and functional correlates
    Peter C Poon
    Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 32:2853-9. 2007
    ..Experimental investigation of an acute thoracic spinal cord injury model in rats involving acute clip compression that simulates human injury...
  32. ncbi Development of an improved canine model of percutaneous spinal cord compression injury by balloon catheter
    Jae Hoon Lee
    Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, 1 Hwayang dong, Kwangjin gu, Seoul 143 701, Republic of Korea
    J Neurosci Methods 167:310-6. 2008
    ..And, this percutaneous spinal cord compression injury model has many potential applications...
  33. ncbi Clinical and radiological correlates of severity and surgery-related outcome in cervical spondylosis
    A Singh
    Department of Surgical Neurology and Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
    J Neurosurg 94:189-98. 2001
    ..The relationships between ambulatory-related data and severity or extent of spinal cord compression were less marked...
  34. ncbi Expression of apoptosis signal-regulating kinase 1 in mouse spinal cord under chronic mechanical compression: possible involvement of the stress-activated mitogen-activated protein kinase pathways in spinal cord cell apoptosis
    Takeshi Takenouchi
    Department of Orthopaedic Surgery, Graduated School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Spine (Phila Pa 1976) 33:1943-50. 2008
    To examine apoptosis signal cascade in neurons and oligodendrocytes under the chronic spinal cord compression of tiptoe-walking Yoshimura (TWY) mouse, which is model of progressive cervical cord compression.
  35. ncbi Delayed neuronal damage related to microglia proliferation after mild spinal cord compression injury
    T Morino
    Department of Orthopaedic Surgery, Ehime University School of Medicine, Shigenobu, 791 0295, Ehime, Japan
    Neurosci Res 46:309-18. 2003
    ..These results suggest that our mild-compression spinal cord injury model showed late-onset or delayed neuronal damage that may be related to pathological microglia proliferation...
  36. ncbi Outcome of decompression surgery for cervical spinal cord injury without bone and disc injury in patients with spinal cord compression: a multicenter prospective study
    O Kawano
    Department of Orthopaedic Surgery, Japan LHWO Spinal Injuries Center, Iizuka, Fukuoka, Japan
    Spinal Cord 48:548-53. 2010
    ..A multicenter prospective study comparing the neurological outcome of patients treated by surgical intervention versus conservative treatment for cervical spinal cord injury (CSCI) without bone and disc injury...
  37. ncbi Costal osteochondroma. A rare cause of spinal cord compression
    W M Tang
    Department of Orthopaedic Surgery, University of Hong Kong, Duchess of Kent Hospital, China
    Spine (Phila Pa 1976) 23:1900-3. 1998
    STUDY DESIGN: Report of a rare cause of spinal cord compression: costal osteochondroma...
  38. ncbi Spinal cord compression and dorsal root injury cause up-regulation of activating transcription factor-3 in large-diameter dorsal root ganglion neurons
    W L Huang
    Neuroscience Centre, Institute of Cell and Molecular Science, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK
    Eur J Neurosci 23:273-8. 2006
    ..The data show for the first time that ATF3 is up-regulated after spinal cord and dorsal root injury, but that this up-regulation is confined to the large-diameter cell population...
  39. ncbi Morphologic and morphometric magnetic resonance imaging features of Doberman Pinschers with and without clinical signs of cervical spondylomyelopathy
    Ronaldo C da Costa
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Am J Vet Res 67:1601-12. 2006
    ....
  40. ncbi The solitary intraspinal vertebral osteochondroma. An unusual cause of compressive myelopathy: features and literature review
    A Khosla
    Department of Radiology, St Louis University Health Sciences Center, Missouri, USA
    Spine (Phila Pa 1976) 24:77-81. 1999
    ..to those already reported makes a total of 41 published cases of solitary vertebral osteochondromas with spinal cord compression. METHODS: Clinical histories, computed tomographic studies, magnetic resonance imaging studies, routine ..
  41. ncbi The role of radiotherapy for metastatic epidural spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Nat Rev Clin Oncol 7:590-8. 2010
    Radiotherapy alone is the most common treatment for metastatic epidural spinal cord compression (MESCC). Decompressive surgery followed by radiotherapy is generally indicated only in 10-15% of MESCC cases...
  42. ncbi Cervical spondylotic myelopathy. Clinicopathologic study on the progression pattern and thin myelinated fibers of the lesions of seven patients examined during complete autopsy
    T Ito
    Department of Pathology, Niigata University, Japan
    Spine (Phila Pa 1976) 21:827-33. 1996
    ..Furthermore, the existence of thin myelinated fibers in the white matter suggests focal demyelinating and remyelinating processes occur in cervical spondylotic myelopathy...
  43. ncbi Osteochondroma of the spine: an enigmatic tumor of the spinal cord. A series of 10 cases
    M C Sharma
    Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
    J Neurosurg Sci 46:66-70; discussion 70. 2002
    ..Osteochondro-mas are common benign bony lesions of long bones but involvement of spine by solitary osteochondroma and its presentation as compressive myelopathy is rare. Most of the literature is in the form of case reports...
  44. pmc Diffusion tensor imaging in the cervical spinal cord
    Ting Song
    Department of Radiology, the Third Affiliated Hospital of Guangzhou Medical University, No 63 Duobao Road, Guangdong, 510150 Guangzhou, China
    Eur Spine J 20:422-8. 2011
    ..Using single-shot spin echo EPI sequence and six non-collinear diffusion directions with b value of 400 s mm(-2), DTI can clearly show the intramedullary microstructure and more lesions than conventional MRI...
  45. ncbi Cerebral spinal fluid flow, venous drainage and spinal cord compression in achondroplastic children: impact of magnetic resonance findings for decompressive surgery at the cranio-cervical junction
    K Brühl
    Department of Neuroradiology, University of Mainz, Germany
    Eur J Pediatr 160:10-20. 2001
    ..the present role of magnetic resonance in the clinical setting is limited to the demonstration of spinal cord compression in individual cases...
  46. ncbi Adenovirus-mediated retrograde transfer of neurotrophin-3 gene enhances survival of anterior horn neurons of twy/twy mice with chronic mechanical compression of the spinal cord
    Kenzo Uchida
    Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Matsuoka, Fukui, Japan
    J Neurosci Res 86:1789-800. 2008
    ..muscle to the cervical spinal accessory motoneurons in 16-week-old adult twy mice with relatively mild spinal cord compression. Four weeks after the AdV-NT-3 or AdV-beta-galactosidase cDNA (LacZ) as a marker gene injection, the ..
  47. ncbi Payer costs for inpatient treatment of pathologic fracture, surgery to bone, and spinal cord compression among patients with multiple myeloma or bone metastasis secondary to prostate or breast cancer
    Arie Barlev
    Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA 91320, USA
    J Manag Care Pharm 16:693-702. 2010
    ..to skeletal-related events (SREs), such as surgery or radiation to the bone, pathologic fracture, and spinal cord compression. Inpatient costs of these and other SREs represent an estimated 49%-59% of total costs related to SREs...
  48. ncbi Malignant spinal-cord compression
    Dheerendra Prasad
    Department of Radiation Oncology, University of Virginia, Charlottesville, VA, USA
    Lancet Oncol 6:15-24. 2005
    ..We also emphasise advances in radiation delivery and the results of a randomised trial that supported aggressive debulking in patients with MSCC...
  49. ncbi High-resolution magnetic resonance imaging and 18FDG-PET findings of the cervical spinal cord before and after decompressive surgery in patients with compressive myelopathy
    Kenzo Uchida
    Department of Orthopaedics and Rehabilitation Medicine, Fukui University Faculty of Medical Sciences, Fukui, Japan
    Spine (Phila Pa 1976) 34:1185-91. 2009
    ..Evaluation of cervical spinal cord (CSC) of patients with compressive myelopathy by magnetic resonance imaging (MRI) and high-resolution (18F)fluoro-deoxyglucose (18FDG) positron emission tomography (PET)...
  50. ncbi Metabolic neuroimaging of the cervical spinal cord in patients with compressive myelopathy: a high-resolution positron emission tomography study
    Kenzo Uchida
    Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medicine, and Biomedical Imaging Research Center, University of Fukui, Matsuoka, Fukui, Japan
    J Neurosurg Spine 1:72-9. 2004
    ....
  51. ncbi Can intramedullary signal change on magnetic resonance imaging predict surgical outcome in cervical spondylotic myelopathy?
    E Wada
    Department of Orthopaedic Surgery, Osaka University Medical School, Suita, Japan
    Spine (Phila Pa 1976) 24:455-61; discussion 462. 1999
    ..A retrospective study evaluating magnetic resonance imaging, computed tomographic myelography, and clinical parameters in patients with cervical spondylotic myelopathy...
  52. pmc Survival, complications and outcome in 282 patients operated for neurological deficit due to thoracic or lumbar spinal metastases
    Karl Ake Jansson
    Oncology Service, Department of Orthopedics, Karolinska Hospital, 171 76 Stockholm, Sweden
    Eur Spine J 15:196-202. 2006
    ..This study shows that important improvement of function can be gained by surgical treatment, but the complication rate was high and many patients died of their disease within the first months of surgery...
  53. ncbi A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury
    W L Huang
    Neuroscience Centre, Institute of Cell and Molecular Science, Queen Mary University of London, UK
    Brain 130:3004-19. 2007
    ..Given that the safety and tolerability of preparations enriched in omega-3 fatty acids is already well-documented, such a combined DHA treatment regime deserves consideration as a very promising approach to SCI management...
  54. ncbi Tumor necrosis factor-alpha and its receptors contribute to apoptosis of oligodendrocytes in the spinal cord of spinal hyperostotic mouse (twy/twy) sustaining chronic mechanical compression
    Tomoo Inukai
    Department of Orthopaedics and Rehabilitation Medicine, The University of Fukui, Fukui, Japan
    Spine (Phila Pa 1976) 34:2848-57. 2009
    ..Chronic spinal cord compression caused neuronal loss, myelin destruction, and axonal degeneration...
  55. ncbi Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse: Part 2. Quantitative neuroanatomical assessment and analysis of the relationships between axonal tracts, residual tissue, and locomotor recovery
    Mital Joshi
    Department of Surgery, Toronto Western Hospital, University of Toronto, Ontario, Canada
    J Neurotrauma 19:191-203. 2002
    ..In addition, we provide a detailed neuroanatomical study of clip compression injury in mice that can be used to study the molecular mechanisms of SCI in knockout and transgenic mice...
  56. ncbi Metastatic bone disease: clinical features, pathophysiology and treatment strategies
    R E Coleman
    Yorkshire Cancer Research Department of Clinical Oncology, Cancer Research Centre, Weston Park Hospital, Sheffield
    Cancer Treat Rev 27:165-76. 2001
    ..These include bone pain, fractures, hypercalcaemia and spinal cord compression, all of which may profoundly impair a patient's quality of life...
  57. ncbi Kinematic study of locomotor recovery after spinal cord clip compression injury in rats
    Olivier Alluin
    Multidisciplinary Team in Locomotor Rehabilitation of the Canadian Institutes of Health Research and Groupe de Recherche sur le Système Nerveux Central of the Fonds de la Recherche en Santé du Québec, Canada Research Chair on the Spinal Cord, Department of Physiology, University of Montreal, Montreal, Quebec, Canada
    J Neurotrauma 28:1963-81. 2011
    ..These findings constitute a kinematic baseline of locomotor recovery after clinically relevant SCI in rats and should be taken into account when evaluating various therapeutic strategies aimed at improving locomotor function...
  58. ncbi A segmental partial laminectomy for cervical spondylotic myelopathy: anatomical basis and clinical outcome in comparison with expansive open-door laminoplasty
    Koji Otani
    Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima City, Japan
    Spine (Phila Pa 1976) 34:268-73. 2009
    ..A comparative study regarding the clinical outcome of the 2-different surgical procedures for patients with cervical spondylotic myelopathy (CSM)...
  59. ncbi Absence of endogenous interleukin-10 enhances secondary inflammatory process after spinal cord compression injury in mice
    Tiziana Genovese
    IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
    J Neurochem 108:1360-72. 2009
    ..Taken together, our results clearly demonstrate that the presence of IL-10 reduces the development of inflammation and tissue injury events associated with spinal cord trauma...
  60. ncbi Cervical spondylotic myelopathy due to chronic compression: the role of signal intensity changes in magnetic resonance images
    Juan Jose Fernández de Rota
    Department of Spinal Surgery, University Hospital Virgen de la Victoria, Malaga, Spain
    J Neurosurg Spine 6:17-22. 2007
    ..The aim of the present study was to determine whether T2-weighted MR imaging can help assess the prognosis of the disease...
  61. ncbi Histological investigation of spinal cord lesions in the spinal hyperostotic mouse (twy/twy): morphological changes in anterior horn cells and immunoreactivity to neurotropic factors
    K Uchida
    Department of Orthopaedic Surgery, School of Medicine, Fukui Medical University, Matsuoka, Japan
    J Neurol 245:781-93. 1998
    ..We speculate that the presence of BDNF and NT-3 in neurons and astrocyte-like cells is proportionate to the severity of chronic mechanical compression and may contribute to the heterotropic neuronal reserve and survival...
  62. ncbi Predictability of operative results of cervical compression myelopathy based on preoperative computed tomographic myelography
    T Koyanagi
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    Spine (Phila Pa 1976) 18:1958-63. 1993
    ..In cervical disc herniation, regardless of the transverse area or duration, the recovery was good, and pathologic state was considered essentially different...
  63. ncbi Multimodal therapy for localized spinal epidural follicular lymphoma
    Christoph Kahl
    Department of Internal Medicine, Division of Hematology and Oncology, University of Rostock, Germany
    Onkologie 33:381-4. 2010
    Myelopathy due to epidural spinal cord compression is rare in patients with malignant lymphoma and most of these patients are diagnosed with high-grade lymphoma. An epidural growth of low-grade lymphoma is even more unusual...
  64. ncbi Increased expression of neurotrophins and their receptors in the mechanically compressed spinal cord of the spinal hyperostotic mouse (twy/twy)
    Kenzo Uchida
    Department of Orthopaedic Surgery, School of Medicine, Fukui Medical University, Shimoaizuki 23, Matsuoka, 910 1193 Fukui, Japan
    Acta Neuropathol 106:29-36. 2003
    ....
  65. ncbi The first score predicting overall survival in patients with metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Cancer 112:157-61. 2008
    The current study was performed to create a scoring system to estimate the survival of patients with metastatic spinal cord compression (MSCC).
  66. ncbi Primary spinal intradural hydatid cyst--a short report
    K Pushparaj
    Department of Neurosurgery, Govt. Rajaji Hospital, Madurai, 625 020, India
    Neurol India 49:203-4. 2001
    ..Primary spinal hydatid cysts are uncommon. Among these, intradural presentation is very rare. A case of primary spinal intradural hydatid cyst presenting as incomplete dorsal cord compression is reported here for its rarity...
  67. ncbi MR diffusion tensor imaging and fiber tracking in spinal cord compression
    David Facon
    Department of Neuroradiology, C H U de Bicêtre, Paris XI University, Le Kremlin Bicetre, France
    AJNR Am J Neuroradiol 26:1587-94. 2005
    ..Our objective is to evaluate the diagnostic accuracy of apparent diffusion coefficient (ADC), fractional anisotropy (FA), and fiber tracking in both acute and slowly progressive spinal cord compressions...
  68. pmc The human G93A-SOD1 mutation in a pre-symptomatic rat model of amyotrophic lateral sclerosis increases the vulnerability to a mild spinal cord compression
    Natasa Jokic
    Centre for Neuroscience and Trauma, Blizard Institute of Cell and Molecular Science, Queen Mary University of London, UK
    BMC Genomics 11:633. 2010
    ....
  69. ncbi Outcome following decompressive surgery for different histological types of metastatic tumors causing epidural spinal cord compression. Clinical article
    Kaisorn L Chaichana
    Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Neurosurg Spine 11:56-63. 2009
    Metastatic epidural spinal cord compression (MESCC) is a relatively common and debilitating complication of metastatic disease that often results in neurological deficits...
  70. ncbi Systematic review of the diagnosis and management of malignant extradural spinal cord compression: the Cancer Care Ontario Practice Guidelines Initiative's Neuro-Oncology Disease Site Group
    D Andrew Loblaw
    Departments of Radiation Oncology and Medicine, Sunnybrook and Women s College Health Science Centre, University of Toronto, Ontario, Canada
    J Clin Oncol 23:2028-37. 2005
    This systematic review describes the diagnosis and management of adult patients with a suspected or confirmed diagnosis of extradural malignant spinal cord compression (MSCC).
  71. pmc Non-Hodgkin's lymphoma presenting with extradural spinal cord compression: functional outcome and survival
    R A Eeles
    Academic Unit of Radiotherapy and Oncology, Royal Marsden Hospital, Adelaide, Australia
    Br J Cancer 63:126-9. 1991
    ..non-Hodgkin's lymphoma (NHL), of intermediate or high grade histology presented with extradural spinal cord compression. All had decompressive surgery...
  72. ncbi Operative results of canal-expansive laminoplasty for cervical spondylotic myelopathy in elderly patients
    J Tanaka
    Department of Orthopaedic Surgery, Tokyo Metropolitan Tama Geriatric Hospital, Japan
    Spine (Phila Pa 1976) 24:2308-12. 1999
    ..CONCLUSIONS: The severity of the clinical picture and the duration of symptoms influenced the outcome of the operation. Despite the advanced age of some patients (> 80), the operation increased the chance of recovery from the disease...
  73. ncbi A remotely controlled model of spinal cord compression injury in mice: toward real-time analysis
    Pascal Kouyoumdjian
    Pathophysiology and Therapy of Sensory and Motor Deficits, Institute for Neurosciences of Montpellier, INSERM U583, Saint Eloi Hospital, Montpellier, France
    J Neurosurg Spine 11:461-70. 2009
    ..The second condition is that the exploration of the consequences of each mechanism of spinal trauma requires modeling the different etiologic aspects of the injury...
  74. pmc Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1-2 trial
    Xin Shelley Wang
    Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Lancet Oncol 13:395-402. 2012
    ..We investigated the clinical benefit of SBRT for managing spinal metastases and reducing cancer-related symptoms...
  75. ncbi Prognostic factors in a series of 504 breast cancer patients with metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 188:340-5. 2012
    This study was performed to identify new significant prognostic factors in breast cancer patients irradiated for metastatic spinal cord compression (MSCC).
  76. ncbi Neurogenic bladder dysfunction in patients with neoplastic spinal cord compression: adaptation of the bladder management strategy to the underlying disease
    A Reitz
    Department of Urology, University of Heidelberg, Germany
    NeuroRehabilitation 21:65-9. 2006
    To study the outcome of different bladder management strategies in patients with neoplastic spinal cord compression.
  77. ncbi Abnormal somatosensory evoked potentials indicate compressive cervical myelopathy in mucopolysaccharidoses
    R Boor
    University Children s Hospital, Johannes Gutenberg University, Mainz, Germany
    Neuropediatrics 31:122-7. 2000
    ..MRI studies in 13 subjects revealed spinal cord compression at the cranio-cervical junction in 10 patients; 5 patients had an increased signal intensity on the T2-..
  78. ncbi Effect of spinal cord signal intensity changes on clinical outcome after surgery for cervical spondylotic myelopathy
    Anooj Chatley
    Department of Neurosurgery, Sanjay Gandhi Institute of Postgraduate Medical Sciences, Lucknow, India
    J Neurosurg Spine 11:562-7. 2009
    ..However, the prognostic significance of signal intensity changes remains controversial. The purpose of this study was to evaluate the effect of spinal cord T2 signal intensity changes on the outcome after surgery for CSM...
  79. ncbi Early graft of neural precursors in spinal cord compression reduces glial cyst and improves function
    Marina Boido
    Neuroscience Institute of the Cavalieri Ottolenghi Foundation, Neuroscience Institute of Turin, Italy
    J Neurosurg Spine 15:97-106. 2011
    ..The authors undertook this study to evaluate grafting of neural tube precursors as a possible therapeutic strategy in a model of spinal cord compression in the mouse.
  80. ncbi Evidence for the role of PI(3) -kinase-AKT-eNOS signalling pathway in secondary inflammatory process after spinal cord compression injury in mice
    Irene Paterniti
    IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
    Eur J Neurosci 33:1411-20. 2011
    ..Overall these results suggest that activation of the Akt pathway in SC tissue subject to SCI is a protective event, triggered in order to protect the injured tissue through a fine tuning of the endothelial NO pathway...
  81. ncbi Quantitative analysis of the spinal cord motoneuron under chronic compression: an experimental observation in the mouse
    H Baba
    Department of Orthopaedic Surgery, Fukui Medical School, Matsuoka, Japan
    J Neurol 243:109-16. 1996
    ..segments were Nissl-stained and counted topographically and then analysed in relation to the extent of spinal cord compression. The number of motoneurons in C1-C3 spinal cord segments decreased significantly with a linear ..
  82. ncbi Metastatic spinal cord compression: radiotherapy outcome and dose fractionation
    Peter J Hoskin
    Mount Vernon Centre for Cancer Treatment, Rickmansworth Road, Northwood, Middlesex HA6 2RN, UK
    Radiother Oncol 68:175-80. 2003
    No standard dose fractionation has been defined for metastatic spinal cord compression. This retrospective analysis was undertaken to explore the impact of hypofractionated treatment compared to conventional multifraction treatment.
  83. ncbi Magnetic resonance imaging vertebral canal and body ratios in Doberman Pinschers with and without disk-associated cervical spondylomyelopathy and clinically normal English Foxhounds
    Steven De Decker
    Department of Small Animal Medicine and Clinical Biology, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium
    Am J Vet Res 72:1496-504. 2011
    ....
  84. ncbi Surgical management of prostate cancer metastatic to the spine
    Brian J Williams
    Department of Neurosurgery, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Neurosurg Spine 10:414-22. 2009
    ..In this study, a series of patients undergoing spinal surgery for metastatic prostate cancer were reviewed to identify predictors of survival and functional outcome...
  85. ncbi Spinal cord compression injury in adult rats initiates changes in dorsal horn remodeling that may correlate with development of neuropathic pain
    Adrianna Kalous
    Pain Management Research Institute and Kolling Institute, University of Sydney at Royal North Shore Hospital, St Leonards, New South Wales, Australia
    J Comp Neurol 513:668-84. 2009
    ..Our results provide further evidence that anatomical reorganization of sensory and nociceptive dorsal horn circuits rostral to an injury could factor in the development or maintenance of spinal cord injury pain...
  86. ncbi Histological and functional evaluation of experimental spinal cord injury: evidence of a stepwise response to graded compression
    J A Gruner
    Cephalon Inc, Department of Experimental Pharmacology, West Chester, PA 19380 4245, USA
    Brain Res 729:90-101. 1996
    ..In contrast, the present study provides evidence that functional and morphological outcome after spinal cord compression injury may occur in a discontinuous, non-graded manner in response to linearly graded injury levels...
  87. ncbi A patient with lung cancer metastatic to the fifth thoracic vertebra and spinal cord compression treated with percutaneous vertebroplasty and I-125 seed implantation
    Yang Zuozhang
    Department of Orthopedics, Tumor Hospital of Yunnan Province, The Third Affiliated Hospital of Kunming Medical College, Kunming, China
    Diagn Interv Radiol 17:384-7. 2011
    ..We report treating a spinal cord compression and T5 metastatic lung cancer patient through percutaneous vertebroplasty and I-125 seed ..
  88. ncbi Mouse spinal cord compression injury is ameliorated by intrathecal cationic manganese(III) porphyrin catalytic antioxidant therapy
    Huaxin Sheng
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 366:220-5. 2004
    ..catalytic antioxidant Mn(III)TDE-2-ImP5+ (AEOL 10150) on outcome from spinal cord compression (SCC) in the mouse...
  89. pmc Apoptosis of neurons and oligodendrocytes in the spinal cord of spinal hyperostotic mouse (twy/twy): possible pathomechanism of human cervical compressive myelopathy
    Kenzo Uchida
    Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Matsuoka Shimoaizuki 23 3, Eiheiji, Fukui, 910 1193, Japan
    Eur Spine J 21:490-7. 2012
    ..Mutant twy/twy mouse developed ossification of the ligamentum flavum at C2-C3 and exhibited progressive paralysis...
  90. pmc A new score predicting the survival of patients with spinal cord compression from myeloma
    Sarah Douglas
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    BMC Cancer 12:425. 2012
    This study was performed to create and validate a scoring system for the survival of patients with malignant spinal cord compression (SCC) from myeloma.
  91. ncbi Spinal cord blood flow changes following systemic hypothermia and spinal cord compression injury: an experimental study in the rat using Laser-Doppler flowmetry
    H Westergren
    Unit of Neurosurgery, Department of Neuroscience, Uppsala University, Sweden
    Spinal Cord 39:74-84. 2001
    ..METHODS: Twenty-four rats were randomized either to thoracic laminectomy only (Th VII-IX) or to 35 g spinal cord compression trauma...
  92. ncbi [Effectiveness and toxicity of reirradiation (Re-RT) for metastatic spinal cord compression (MSCC)]
    Dirk Rades
    Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Universitatsklinikum, Hamburg Eppendorf
    Strahlenther Onkol 181:595-600. 2005
    Radiation myelopathy is a serious late toxicity after radiotherapy (RT) of metastatic spinal cord compression (MSCC). The risk of myelopathy depends on the equivalent dose in 2-Gy fractions (EQD2)...
  93. ncbi Matched pair analysis comparing surgery followed by radiotherapy and radiotherapy alone for metastatic spinal cord compression
    Dirk Rades
    University of Lubeck, Lubeck, Germany
    J Clin Oncol 28:3597-604. 2010
    ..That study was limited to highly selected patients. Additional studies comparing surgery plus radiotherapy to radiotherapy could better clarify the role of surgery...
  94. ncbi The optimal dose fractionation schema for malignant extradural spinal cord compression
    D Andrew Loblaw
    Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Canada
    J Support Oncol 9:121-4. 2011
    Malignant epidural spinal cord compression is a dreaded complication of malignancy. Fortunately, it does not happen very often...
  95. ncbi A multinational, multidisciplinary consensus for the diagnosis and management of spinal cord compression among patients with mucopolysaccharidosis VI
    Guirish A Solanki
    Department of Paediatric Neurosurgery, Birmingham Children s Hospital, Birmingham B4 6NH, UK
    Mol Genet Metab 107:15-24. 2012
    ..Therefore, the key to optimal patient care is to implement best practices through meaningful communication among treatment team members at each center and among MPS VI specialists worldwide...
  96. ncbi Potential usefulness of 18F-2-fluoro-deoxy-D-glucose positron emission tomography in cervical compressive myelopathy
    H Baba
    Department of Orthopaedic Surgery, School of Medicine, Fukui Medical University, Japan
    Spine (Phila Pa 1976) 24:1449-54. 1999
    ..18FDG-PET images may also offer additional information related to neuronal dysfunction induced by mechanical compression...
  97. ncbi A validated scoring system to identify long-term survivors after radiotherapy for metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Strahlenther Onkol 189:462-6. 2013
    This study aimed to develop and validate a scoring system to identify long-term survivors after conventional radiotherapy (RT) for metastatic spinal cord compression (MSCC).
  98. ncbi Biomechanical effects of spinal cord compression due to ossification of posterior longitudinal ligament and ligamentum flavum: a finite element analysis
    Yoon Hyuk Kim
    Department of Mechanical Engineering, Kyung Hee University, Yongin, Republic of Korea
    Med Eng Phys 35:1266-71. 2013
    ..in the cord and the cross-sectional area of the cord were investigated for various grades and shapes of spinal cord compression in OPLL and OLF...
  99. ncbi Brachytelephalangic chondrodysplasia punctata with severe spinal cord compression: report of four new cases
    Arnaud Garnier
    Pediatric Intensive Care Unit, Service de Reanimation, AP HP, Hopital Robert Debre, and Université Paris VII, Faculté de Médecine Denis Diderot, IFR02, 48, boulevard Serurier, 75019, Paris, France
    Eur J Pediatr 166:327-31. 2007
    ..Although the symptoms are usually mild, severe spinal cord compression by dysplastic vertebras may develop...
  100. ncbi Extradural thoracic spinal cord compression: unusual initial presentation of post-transplant lymphoproliferative disorder
    Nicholas A Bakker
    Department of Neurosurgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Heart Lung Transplant 27:1165-8. 2008
    ..To our knowledge, this is the first reported case of PTLD presenting with signs and symptoms of spinal cord compression. The differential diagnosis of spinal cord compression in a patient who has had a transplant should ..
  101. ncbi Acute spinal cord compression and calcium pyrophosphate deposition disease. Case illustration
    Vincent Baty
    Departement de Medecine, Clinique Mutualiste Eugène André, Lyon, France
    J Neurosurg 99:240. 2003

Research Grants49

  1. Intubation Mechanics of the Stable and Unstable Cervical Spine
    BRANDON GERAD SANTONI; Fiscal Year: 2013
    ..and (2) which intubation techniques and devices minimize cervical spine movement and the possibility of spinal cord compression. To fill this knowledge gap, the aims of this project are to quantify the pattern of cervical spine ..
  2. Profiling and Characterizing Prostate Cancer Tumor Dormancy in the Bone Marrow
    ROBERT LOUIS VESSELLA; Fiscal Year: 2010
    ..a nidus for disease recurrence and their activation can lead to the replacement of bone marrow (BM), spinal cord compression, severe bone pain, cachexia and death...
  3. Characterization of WWOX, the Cancer Gene Spanning FRA16D
    C Marcelo Aldaz; Fiscal Year: 2013
    ..Patients suffer from severe pain, spontaneous fractures and possible spinal cord compression caused by development of osteolytic lesions...
  4. CLINICAL AND CLASSICAL EPIDEMIOLOGY IN ONCOLOGY
    James Talcott; Fiscal Year: 1991
    ..these techniques to cancer patient populations: those with fever and neutropenia and those with suspected spinal cord compression. The proposed studies of patients with fever and neutropenia build on a retrospective study which ..
  5. Genes important in breast cancer metastasis
    Robin Anderson; Fiscal Year: 2003
    ..disease have bone involvement, resulting in severe pain, pathological fractures, hypercalcemia and spinal cord compression. These complications are a significant clinical problem for which there is no effective treatment...
  6. EIHC and Prostate Cancer Adhesion to Bone Endothelium
    Carlton Cooper; Fiscal Year: 2004
    ..cancer bone metastasis is a major clinical problem and is commonly associated with intractable pain and spinal cord compression. Nearly 100% of men who die of prostate cancer have bone metastases...
  7. Novel Total Disc Implants
    Ashok Khandkar; Fiscal Year: 2004
    ..When conservative treatment fails, and diagnostic imaging evidence of nerve root or spinal cord compression is apparent, a discectomy, followed by fusion of the segment is performed...
  8. Molecular Modulators of Breast-Bone Metastasis
    John Price; Fiscal Year: 2004
    ..occurs frequently and causes significant problems including pain, fracture, immobility, and even spinal cord compression leading to paralysis...
  9. Prevention of Neck Injuries in Older Adults During Rear Motor Vehicle Collsions
    PAUL IVANCIC; Fiscal Year: 2009
    ..The proposed project will provide important research-based data that may form the basis for future safety standards and help to decrease the frequency and severity of neck injuries in older adults, thus benefiting society. ..
  10. Artificial Nutrition in Terminally Ill Cancer Patients
    Sydney Dy; Fiscal Year: 2007
    ..Dy with the skills she needs to develop into an independent clinical researcher in oncology palliative care decision-making and health services research. ..
  11. ADAM: Androgen Deprivation vs. Antiandrogen Monotherapy
    Matthew Smith; Fiscal Year: 2004
    ..In addition, this project will provide important insights into the relative contributions of testosterone and estrogen in bone metabolism, and maintenance of muscle size and strength in older men. ..
  12. Paget's Disease of Bone/Dysplasia:Advances/Challenges
    G Roodman; Fiscal Year: 2006
    ..to become aware of the effectiveness of the various drugs that can be used to treat the two disorders; 5.) to understand the role of surgery in managing the two disorders. ..
  13. Pain Mechanisms and the Development of Analgesics
    Tony Yaksh; Fiscal Year: 2006
    ..g. COX2 inhibitors, GABApentin, ziconotide) and failures (NK1 antagonist). [unreadable] [unreadable] [unreadable]..
  14. Skin Adaptation to Mechanical Stress
    Joan Sanders; Fiscal Year: 2006
    ..By understanding the process of skin adaptation (natural skin strengthening) at both a cellular and molecular level, therapies to encourage skin adaptation before breakdown occurs can be intelligently pursued. ..
  15. INTERFACE MECHANICS, MATERIALS AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2007
    ..The development of methods to predict and overcome the detrimental effects of residual limb shape change and ultimately prevent soft-tissue breakdown will help to prevent secondary disability and morbidity in the amputee population. ..
  16. Effect of vertebral endplate composition on disc health
    Frank Acosta; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  17. Analysis of Cartilage Morphology and sGAG Content via Contrast Enhanced Micro-CT
    Robert Guldberg; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  18. University of Texas SPORE in Prostate Cancer
    Christopher Logothetis; Fiscal Year: 2007
    ..The achievement of the aims of this Prostate Cancer SPORE proposal will contribute to the development of effective treatments for patients with prostate cancer. ..
  19. Program Project Grant-Pathobiology of Paget's Disease
    G Roodman; Fiscal Year: 2007
    ..The knowledge gained from this P01 grant will offer important insights for normal bone cell biology especially for understanding the paracrine regulation of osteoblasts by OCLs. ..
  20. Modulation of MSC Differentiation for Fibrocartilage Tissue Engineering
    Marc E Levenston; Fiscal Year: 2010
    ..This will aid in the development of functional tissue engineered replacements and may aid in understanding why particular approaches to cartilage repair succeed or fail. ..
  21. Characterization of Toxicity with Spinal Opiates
    Tony L Yaksh; Fiscal Year: 2010
    ..The present studies aim to define the mechanisms of granuloma formation and point to specific methods to prevent granuloma formation, which will increase the utility and reduce the risks of this important pain therapy. ..
  22. Intrathecal enzyme therapy for mucopolysaccharidosis I
    Patricia I Dickson; Fiscal Year: 2010
    ..Intrathecal enzyme therapy will be studied in patients with spinal cord compression, which is a debilitating condition common in MRS I patients that often requires spinal surgery to correct...
  23. Phosphodiesterase-inhibitors, vascular integrity and SCI
    Raymond J Grill; Fiscal Year: 2010
    ..We propose to explore the nature of this chronic BSCB dysfunction over a time course of 1 year. In addition, we will also explore whether treatment with PDE-ls in the acute phase results in a repaired BSCB in the chronic. ..
  24. Spatiotemporal Progression of Meniscal Degradation
    Marc E Levenston; Fiscal Year: 2010
    ..These studies will provide important new insights into the progression of meniscal degeneration and could lead to novel diagnostic or therapeutic targets to prevent or delay the progression of OA. ..
  25. OSTEOCLASTS FROM TRANSGENIC MICE
    G Roodman; Fiscal Year: 2009
    ..Our long-term goal will be to characterize the role of ADAM8/a9b1 in the bone destruction which accompanies collagen induced arthritis, which will be started in grant year 5. ..
  26. Pilot/Phase I Study of Intrathecal Laronidase for Spinal Cord Compression in Muco
    Patricia Dickson; Fiscal Year: 2009
    ..Up to 10 study participants with spinal cord compression due to MPS will be studied...
  27. Assessment of Tissue Response to Stress
    Joan Sanders; Fiscal Year: 2006
    ..this technology could be applied to other areas of rehabilitation, for example, shoe design for patients with insensate feet, cushion design for wheelchair users, and mattress design for bedridden patients [unreadable] [unreadable]..
  28. Polysomal RNA Antitumor Immunity
    John Chi; Fiscal Year: 2005
    ..Results from these experiments will help characterize the potential use of dendritic cells transfected with polysomal RNA in creating antigen specific tumor vaccines for brain tumors. ..
  29. INTERFACE MECHANICS, MATERIALS, AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2003
    ....
  30. Mechanical Stimulation for TMJ Disc Tissue Engineering
    MARC LEVENSTON; Fiscal Year: 2003
    ..abstract_text> ..
  31. NERVE REPAIR BY SYNTHETIC AND BIOLOGICAL POLYMERS
    Riyi Shi; Fiscal Year: 2003
    ..Frequent consultation with a neurosurgeon, who is a member of the research team, will provide necessary input to direct the study and experiments towards clinically relevant solutions for transection nerve injuries. ..
  32. PATHOBIOLOGY OF THE OSTEOCLAST IN PAGETS DISEASE
    G Roodman; Fiscal Year: 2002
    ..abstract_text> ..
  33. ACUTE REPAIR OF SPINAL INJURY WITH FUSOGENS
    Richard Borgens; Fiscal Year: 2002
    ..An anatomical evaluation of the degree of axonal repair between control and PEG treated spinal cords using a horseradish peroxidase dye exclusion test and conventional histology. ..
  34. NEW BIOMATERIALS TO MINIMIZE SCAR TISSUE FORMATION
    Joan Sanders; Fiscal Year: 2002
    ..e. soft-tissue complications that require surgical repair through use of a biomaterial. The new materials will prevent scar tissue formation and reduce the occurrence of secondary complications. ..
  35. Phase II Trial of Thalidomide in Primary Amyloidosis
    Angela Dispenzieri; Fiscal Year: 2002
    ..The ultimate goal of the proposed studies is to improve the prognosis of patient with this fatal disease. ..
  36. NEUROSCIENCE OF HIV CONFERENCE
    Joseph Berger; Fiscal Year: 2002
    ..Dr. Brian Wigdahl, international co-chair of the ISNV, is a co-investigator on this grant. ..
  37. CERVICAL SPINE INJURIES IN FRONT, REAR AND SIDE IMPACTS
    Manohar Panjabi; Fiscal Year: 2004
    ....
  38. JCV Virus Expression in Oropharynx and HIV
    Joseph Berger; Fiscal Year: 2004
    ..This line of investigation would add credence to an oropharyngeal mechanism of JCV transmission and may ultimately lead to the clinical identification of an acute illness attributable to this pathogen. ..
  39. Tensile Stimulation of Tissue Engineered Fibrocartilage
    MARC LEVENSTON; Fiscal Year: 2004
    ..abstract_text> ..
  40. Quality of Life in Patients with Brain Metastases
    Joseph King; Fiscal Year: 2005
    ..abstract_text> ..
  41. NEUROBIOLOGY OF PAIN
    Tony Yaksh; Fiscal Year: 2005
    ..The complexity of the problems and the diversity of the training approaches emphasize that the training received by these fellows will provide a broad base of knowledge relevant to wide areas of neurobiology. ..
  42. Spinal Galanin and its Receptors in Pain Processing
    Tony Yaksh; Fiscal Year: 2005
    ..We believe the outcome of these studies will provide direct evidence for the role played by this spinal peptidergic system in pain and point to the development of novel anti-hyperpathic agents. ..
  43. DEVELOPMENTAL ASPECTS OF OSTEOCLAST FORMATION IN VITRO
    G Roodman; Fiscal Year: 2005
    ....
  44. PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDS
    Tony Yaksh; Fiscal Year: 2005
    ....
  45. HIV Neuroprotection Workshop
    Joseph Berger; Fiscal Year: 2004
    ..The proposed conference is the first of its kind to highlight neuroprotection in HIV CNS and PNS disorders. By coupling this meeting with the International Symposium on Neurovirology this synergy can be exploited. ..
  46. CLINICAL RESEARCH IN NEURO-ONCOLOGY
    ROY PATCHELL; Fiscal Year: 2004
    ..abstract_text> ..
  47. MR PREDICTORS OF RESPONSE TO HAART IN HIV DEMENTIA
    Joseph Berger; Fiscal Year: 2004
    ..It will also open novel avenues for exploring the differential sensitivities of these pathways to HAART, and suggest unique therapeutic options. ..
  48. INTERFACE MECHANICS, MATERIALS, AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2002
    ....