movement disorders

Summary

Summary: Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.

Top Publications

  1. ncbi Sensorimotor integration in movement disorders
    Giovanni Abbruzzese
    Dipartimento di Scienze Neurologiche e della Visione, Universita di Genova, Via de Tony 5, 16132 Genoa, Italy
    Mov Disord 18:231-40. 2003
  2. ncbi Movement disorders in spinocerebellar ataxias
    Judith van Gaalen
    Department of Neurology, Donders Institute of Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mov Disord 26:792-800. 2011
  3. pmc Striatal microcircuitry and movement disorders
    Aryn H Gittis
    Gladstone Institute of Neurological Disease, San Francisco, CA, USA
    Trends Neurosci 35:557-64. 2012
  4. ncbi Dystonia and the cerebellum: a new field of interest in movement disorders?
    Pavel Filip
    Central European Institute of Technology, CEITEC MU, Behavioral and Social Neuroscience Research Group, Masaryk University, Brno, Czech Republic
    Clin Neurophysiol 124:1269-76. 2013
  5. ncbi Re-emergence of striatal cholinergic interneurons in movement disorders
    Antonio Pisani
    Fondazione Santa Lucia IRCCS, and Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00135, Rome, Italy
    Trends Neurosci 30:545-53. 2007
  6. ncbi Iron dysregulation in movement disorders
    Petr Dusek
    Parkinson s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Neurobiol Dis 46:1-18. 2012
  7. ncbi Neuronal oscillations in the basal ganglia and movement disorders: evidence from whole animal and human recordings
    William D Hutchison
    Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada, M5T 2S8
    J Neurosci 24:9240-3. 2004
  8. ncbi Functional (psychogenic) movement disorders: merging mind and brain
    Mark J Edwards
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK
    Lancet Neurol 11:250-60. 2012
  9. ncbi Antibody-mediated neuronal cell signaling in behavior and movement disorders
    Christine A Kirvan
    Department of Biological Sciences, California State University Sacramento, Sacramento, CA 95618 6077, USA
    J Neuroimmunol 179:173-9. 2006
  10. pmc Aberrant supplementary motor complex and limbic activity during motor preparation in motor conversion disorder
    Valerie Voon
    Behavioral and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Mov Disord 26:2396-403. 2011

Detail Information

Publications355 found, 100 shown here

  1. ncbi Sensorimotor integration in movement disorders
    Giovanni Abbruzzese
    Dipartimento di Scienze Neurologiche e della Visione, Universita di Genova, Via de Tony 5, 16132 Genoa, Italy
    Mov Disord 18:231-40. 2003
    Although current knowledge attributes movement disorders to a dysfunction of the basal ganglia-motor cortex circuits, abnormalities in the peripheral afferent inputs or in their central processing may interfere with motor program ..
  2. ncbi Movement disorders in spinocerebellar ataxias
    Judith van Gaalen
    Department of Neurology, Donders Institute of Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mov Disord 26:792-800. 2011
    ..spinocerebellar ataxias (SCAs) can present with a large variety of noncerebellar symptoms, including movement disorders. In fact, movement disorders are frequent in many of the various SCA subtypes, and they can be the ..
  3. pmc Striatal microcircuitry and movement disorders
    Aryn H Gittis
    Gladstone Institute of Neurological Disease, San Francisco, CA, USA
    Trends Neurosci 35:557-64. 2012
    ..Clinically, the basal ganglia receive the most attention for their role in movement disorders. Recent advances in technology have opened new avenues of research into the structure and function of basal ..
  4. ncbi Dystonia and the cerebellum: a new field of interest in movement disorders?
    Pavel Filip
    Central European Institute of Technology, CEITEC MU, Behavioral and Social Neuroscience Research Group, Masaryk University, Brno, Czech Republic
    Clin Neurophysiol 124:1269-76. 2013
    ..It is clear that as long as the cerebellum's role in dystonia genesis remains unexamined, it will be difficult to significantly improve the current standards of dystonia treatment or to provide curative treatment...
  5. ncbi Re-emergence of striatal cholinergic interneurons in movement disorders
    Antonio Pisani
    Fondazione Santa Lucia IRCCS, and Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00135, Rome, Italy
    Trends Neurosci 30:545-53. 2007
    ..This review gives an overview of these recent experimental and clinical studies, placing them within the context of the pathogenesis of movement disorders.
  6. ncbi Iron dysregulation in movement disorders
    Petr Dusek
    Parkinson s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
    Neurobiol Dis 46:1-18. 2012
    ..Other, more common degenerative movement disorders, such as Parkinson's disease, Huntington's disease, multiple system atrophy and progressive supranuclear ..
  7. ncbi Neuronal oscillations in the basal ganglia and movement disorders: evidence from whole animal and human recordings
    William D Hutchison
    Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada, M5T 2S8
    J Neurosci 24:9240-3. 2004
  8. ncbi Functional (psychogenic) movement disorders: merging mind and brain
    Mark J Edwards
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK
    Lancet Neurol 11:250-60. 2012
    Functional (psychogenic) movement disorders (FMD) are part of the wide spectrum of functional neurological disorders, which together account for over 16% of patients referred to neurology clinics...
  9. ncbi Antibody-mediated neuronal cell signaling in behavior and movement disorders
    Christine A Kirvan
    Department of Biological Sciences, California State University Sacramento, Sacramento, CA 95618 6077, USA
    J Neuroimmunol 179:173-9. 2006
    Behavioral and movement disorders may have antibody responses where mimicry and signal transduction may lead to neuropsychiatric abnormalities...
  10. pmc Aberrant supplementary motor complex and limbic activity during motor preparation in motor conversion disorder
    Valerie Voon
    Behavioral and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Mov Disord 26:2396-403. 2011
    ....
  11. ncbi Spastic movement disorder: impaired reflex function and altered muscle mechanics
    Volker Dietz
    Spinal Cord Injury Centre, University of Zurich, Switzerland
    Lancet Neurol 6:725-33. 2007
    ..tendon tap reflexes associated with muscle hypertonia are generally thought to be responsible for spastic movement disorders. Most antispastic treatments are, therefore, directed at the reduction of reflex activity...
  12. ncbi Peripheral trauma and movement disorders: a systematic review of reported cases
    Diana E van Rooijen
    Department of Neurology, Leiden University Medical Centre, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Neurol Neurosurg Psychiatry 82:892-8. 2011
    ..To perform a systematic review of cases reported in the literature in which a peripheral trauma preceded the onset of a movement disorder (MD)...
  13. ncbi Transcranial sonography in movement disorders
    Daniela Berg
    Center of Neurology, Department of Neurodegeneration and Hertie Institute of Clinical Brain Research, University of Tubingen, Germany
    Lancet Neurol 7:1044-55. 2008
    ..brain structures has become an important tool for the diagnosis and differential diagnosis of various movement disorders. The most widely recognised finding for movement disorders has been an increase in echogenicity of the ..
  14. ncbi Brain structure in movement disorders: a neuroimaging perspective
    Bogdan Draganski
    Departement des neurosciences cliniques, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
    Curr Opin Neurol 23:413-9. 2010
    An overview of recent advances in structural neuroimaging and their impact on movement disorders research is presented.
  15. ncbi Objective evaluation of manual performance deficits in neurological movement disorders
    Dennis A Nowak
    Department of Psychiatry III, University of Ulm, Leimgrubenweg 12 14, D 89075 Ulm, Germany
    Brain Res Rev 51:108-24. 2006
    Impaired hand function is a frequent finding in movement disorders. The skilled control of prehensile finger forces is an essential feature of tool use in daily life...
  16. ncbi Evidence-based review and assessment of botulinum neurotoxin for the treatment of movement disorders
    Mark Hallett
    The George Washington University School of Medicine and Health Sciences, Ross Hall, Department of Neurology, 2300 Eye Street, NW Suite 713W, Washington, DC 20037, USA
    Toxicon 67:94-114. 2013
    ..To assess the efficacy and safety of BoNT injections for the treatment of certain movement disorders, including blepharospasm, hemifacial spasm, oromandibular dystonia, cervical dystonia, focal limb dystonias, ..
  17. ncbi Classification of movement disorders
    Stanley Fahn
    Department of Neurology, Columbia University Medical Center, New York, New York, USA
    Mov Disord 26:947-57. 2011
    The classification of movement disorders has evolved. Even the terminology has shifted, from an anatomical one of extrapyramidal disorders to a phenomenological one of movement disorders...
  18. ncbi Long-term efficacy of botulinum toxin A in treatment of various movement disorders over a 10-year period
    G Y R Hsiung
    Movement Disorders Clinic, Department of Clinical Neurosciences at University of Calgary, Alberta, Canada
    Mov Disord 17:1288-93. 2002
    Although botulinum toxin A (BTX) has been licensed in Canada for treatment of various movement disorders since 1990, few clinical studies regarding its long-term efficacy and side effects have been reported...
  19. ncbi HIV-related movement disorders: epidemiology, pathogenesis and management
    Francisco Cardoso
    Movement Disorders Clinic, Department of Psychiatry and Neurology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    CNS Drugs 16:663-8. 2002
    Clinically relevant movement disorders are identified in 3% of patients with HIV infection seen at tertiary referral centres...
  20. pmc Mechanisms and targets of deep brain stimulation in movement disorders
    Matthew D Johnson
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Neurotherapeutics 5:294-308. 2008
    ..known as deep brain stimulation (DBS), has become a preferred surgical treatment for medication-refractory movement disorders. Despite its remarkable clinical success, the therapeutic mechanisms of DBS are still not completely ..
  21. ncbi Sensorimotor disturbances in chronic neck pain--range of motion, peak velocity, smoothness of movement, and repositioning acuity
    Per Sjölander
    Southern Lapland Research Department, Postgatan 7, SE 912 32 Vilhelmina, Sweden
    Man Ther 13:122-31. 2008
    ..The observed individuality in sensorimotor disturbances emphasizes the importance of developing specific rehabilitation programs for specific dysfunctions, and of using objective and quantitative methods for evaluation of rehabilitation...
  22. ncbi Effects of trunk restraint combined with intensive task practice on poststroke upper extremity reach and function: a pilot study
    Michelle L Woodbury
    Brain Rehabilitation Research Center, Malcom Randall Veterans Administration Medical Center, Department of Occupational Therapy, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, USA
    Neurorehabil Neural Repair 23:78-91. 2009
    ..Little attention is typically given to arm-trunk kinematics during task practice. Preventing compensatory trunk motion during short-term practice immediately improves kinematics, but effects of longer-term practice are unknown...
  23. ncbi Assessment: Botulinum neurotoxin for the treatment of movement disorders (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
    D M Simpson
    Department of Neurology, Mount Sinai Medical Center, New York, NY, USA
    Neurology 70:1699-706. 2008
    To perform an evidence-based review of the safety and efficacy of botulinum neurotoxin (BoNT) in the treatment of movement disorders.
  24. ncbi A systematic review of the clinimetric properties of neuromotor assessments for preterm infants during the first year of life
    Alicia J Spittle
    Victorian Infant Brain Studies, Murdoch Childrens Research Institute, Parkville, Melbourne, Australia
    Dev Med Child Neurol 50:254-66. 2008
    ..85). Selection of motor assessment tools during the first year of life for infants born preterm will depend on the intended purpose of their use for discrimination, prediction, and/or evaluation...
  25. ncbi Zebrafish as a new animal model for movement disorders
    Laura Flinn
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, UK
    J Neurochem 106:1991-7. 2008
    ..We will then summarize all work undertaken so far to establish zebrafish as a new animal model for movement disorders and will finally emphasize its particular strength - amenability to high throughput in vivo drug screening.
  26. ncbi A randomized controlled trial of gravity-supported, computer-enhanced arm exercise for individuals with severe hemiparesis
    Sarah J Housman
    Sensory Motor Performance Program, Rehabilitation Institute of Chicago, Chicago, Illinois 60660, USA
    Neurorehabil Neural Repair 23:505-14. 2009
    ..The purpose of this study was to compare semiautonomous training with T-WREX and conventional semiautonomous exercises that used a tabletop for gravity support...
  27. ncbi Sydney Multicenter Study of Parkinson's disease: non-L-dopa-responsive problems dominate at 15 years
    Mariese A Hely
    Department of Neurology, Westmead Hospital, Westmead New South Wales, Australia
    Mov Disord 20:190-9. 2005
    ....
  28. pmc Postural dysfunction in children with cerebral palsy: some implications for therapeutic guidance
    Eva Brogren Carlberg
    Department of Woman and Child Health, Neuropediatric Research Unit, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Neural Plast 12:221-8; discussion 263-72. 2005
    ..The challenge facing us now is to provide evidence about the efficacy of specific treatment approaches facilitating that children reach an optimal level of functioning in daily life...
  29. ncbi Autism and Asperger's disorder: are they movement disorders involving the cerebellum and/or basal ganglia?
    Ashwini Nayate
    Department of Psychological Medicine, Monash University, Clayton, Vic, Australia
    Brain Res Bull 67:327-34. 2005
    ..This review examines the role of the frontostriatal and cerebellar motor systems in the behavioural features of autism and AD, with gait as a proxy, and discusses difficulties with their diagnosis and their possible pathogenesis...
  30. ncbi Hip displacement in cerebral palsy
    Brendan Soo
    Department of Orthopaedic Surgery, Royal Children s Hospital, Flemington Road, Parkville, Victoria 3052, Australia
    J Bone Joint Surg Am 88:121-9. 2006
    ..Knowledge regarding its overall incidence and associated risk factors can facilitate treatment of these children...
  31. ncbi Association of surgically acquired motor and language deficits on overall survival after resection of glioblastoma multiforme
    Matthew J McGirt
    Department of Neurosurgery, The Neuro Oncology Surgical Outcomes Research Laboratory, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Neurosurgery 65:463-9; discussion 469-70. 2009
    ..We set out to determine whether new-onset postoperative motor or speech deficits were associated with survival in our institutional experience with glioblastoma multiforme (GBM)...
  32. ncbi Movement disorders in complex regional pain syndrome
    Jacobus J Van Hilten
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Pain Med 11:1274-7. 2010
    About 25% of the patients with complex regional pain syndrome (CRPS) suffer movement disorders, including loss of voluntary control, bradykinesia, dystonia, myoclonus, and tremor...
  33. ncbi Management of referred deep brain stimulation failures: a retrospective analysis from 2 movement disorders centers
    Michael S Okun
    Department of Neurology, University of Florida, Movement Disorders Center, McKnight Brain Institute, Gainesville, FL 32610, USA
    Arch Neurol 62:1250-5. 2005
    ..An attempt is made herein to evaluate the reasons for DBS failure in a series of such patients and to make recommendations to improve overall DBS outcomes...
  34. ncbi Fatigue rating scales critique and recommendations by the Movement Disorders Society task force on rating scales for Parkinson's disease
    Joseph H Friedman
    NeuroHealth, Parkinson s Disease and Movement Disorders Center, Warwick, Rhode Island 02886, USA
    Mov Disord 25:805-22. 2010
    ..The committee concluded that current scales are adequate for fatigue studies in PD but that studies on sensitivity and specificity of the scales are still needed...
  35. ncbi Preventing and controlling dyskinesia in Parkinson's disease--a view of current knowledge and future opportunities
    Peter Jenner
    Neurodegenerative Diseases Research Centre, School of Health and Biomedical Sciences, King s College, London, United Kingdom
    Mov Disord 23:S585-98. 2008
    ..Certainly, the use of CDD can reduce dyskinesia intensity but other factors also influence its appearance and it is these that we need to study at the preclinical level if effective therapies are to be developed...
  36. ncbi Assessment of upper-limb sensorimotor function of subacute stroke patients using visually guided reaching
    Angela M Coderre
    Queen s University, Kingston, ON, Canada
    Neurorehabil Neural Repair 24:528-41. 2010
    ..Using robotic technology, we examined the ability of a visually guided reaching task to assess the sensorimotor function of patients with stroke...
  37. ncbi Injectable neuromuscular blockade in the treatment of spasticity and movement disorders
    Ann H Tilton
    Department of Neurology, Section of Child Neurology, Louisiana State University Health Science Center, New Orleans, LA, USA
    J Child Neurol 18:S50-66. 2003
    ..The treatment program, in which chemodenervation is only one tool, requires a multidisciplinary evaluation and individualized plan to address the whole patient...
  38. ncbi Prevalence of movement disorders in men and women aged 50-89 years (Bruneck Study cohort): a population-based study
    Gregor K Wenning
    Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
    Lancet Neurol 4:815-20. 2005
    There is emerging awareness that movement disorders rank among the most common neurological diseases. However, the overall burden of these disorders in the general community is not well defined...
  39. ncbi Robotic devices as therapeutic and diagnostic tools for stroke recovery
    Bruce T Volpe
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, Burke Cornell Medical Research Institute, White Plains, New York 10605, USA
    Arch Neurol 66:1086-90. 2009
    ..Additionally, robotic devices can measure motor performance objectively and will contribute to a detailed phenotype of stroke recovery...
  40. ncbi Microdeletions detected using chromosome microarray in children with suspected genetic movement disorders: a single-centre study
    Russell C Dale
    Movement Disorder Clinic, Institute of Neuroscience and Muscle Research, Children s Hospital at Westmead, University of Sydney, Sydney, New South Wales, Australia
    Dev Med Child Neurol 54:618-23. 2012
    ..We examined whether CMA is a valuable tool in the investigation of children with suspected genetic movement disorders.
  41. ncbi Neuropsychiatric assessment of patients with hyperkinetic and hypokinetic movement disorders
    I Litvan
    Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 9130, USA
    Arch Neurol 55:1313-9. 1998
    ....
  42. ncbi 'Jumping to conclusions' bias in functional movement disorders
    Isabel Pareés
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 83:460-3. 2012
    ..In this study, the authors aimed to specifically investigate whether patients with functional movement disorders have abnormalities in probabilistic reasoning.
  43. ncbi Atypical movement disorders in antiphospholipid syndrome
    Davide Martino
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 21:944-9. 2006
    b>Movement disorders have only rarely been reported in association with antiphospholipid syndrome (APS). In such cases, chorea is the most common disorder observed, with occasional reports of hemidystonia, Parkinsonism, and hemiballism...
  44. ncbi Movement disorders and inborn errors of metabolism in adults: a diagnostic approach
    F Sedel
    Federation of Nervous System Diseases, Salpetriere Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    J Inherit Metab Dis 31:308-18. 2008
    Inborn errors of metabolism (IEMs) may present in adolescence or adulthood with various movement disorders including parkinsonism, dystonia, chorea, tics or myoclonus...
  45. pmc Complex movement disorders at disease onset in childhood narcolepsy with cataplexy
    Giuseppe Plazzi
    Department of Neurological Sciences, University of Bologna, 40123 Bologna, Italy
    Brain 134:3480-92. 2011
    ..Further studies are warranted to assess clinical course and whether the associated movement disorder is also caused by hypocretin deficiency or by additional neurochemical abnormalities...
  46. ncbi Genetics of Parkinson disease and other movement disorders
    Kishore R Kumar
    Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Lubeck, Lubeck, Germany
    Curr Opin Neurol 25:466-74. 2012
    We will review the recent advances in the genetics of Parkinson disease and other movement disorders such as dystonia, essential tremor and restless legs syndrome (RLS).
  47. pmc Functional brain networks and abnormal connectivity in the movement disorders
    Kathleen L Poston
    Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA
    Neuroimage 62:2261-70. 2012
    Clinical manifestations of movement disorders, such as Parkinson's disease (PD) and dystonia, arise from neurophysiological changes within the cortico-striato-pallidothalamocortical (CSPTC) and cerebello-thalamo-cortical (CbTC) circuits...
  48. ncbi Quadrupedal coordination of bipedal gait: implications for movement disorders
    Volker Dietz
    Spinal Cord Injury Centre, Balgrist University Hospital, Forchstr 340, Ch 8008 Zurich, Switzerland
    J Neurol 258:1406-12. 2011
    ..This has consequences for the limb coordination in movement disorders such as in Parkinson's disease (PD) and after stroke...
  49. ncbi Spectrum of movement disorders in neuroferritinopathy
    Douglas E Crompton
    Department of Neurology, Regional Neurosciences Centre, Newcastle upon Tyne, United Kingdom
    Mov Disord 20:95-9. 2005
    ..The diagnosis should therefore be considered in patients with a wide variety of different movement disorders. Characteristic neuroimaging assists in identifying affected individuals.
  50. ncbi Psychogenic movement disorders: past developments, current status, and future directions
    Anthony E Lang
    Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 26:1175-86. 2011
    As the field of movement disorders has developed and matured over the past 25 years, psychogenic movement disorders have become increasingly recognized in subspecialty clinics...
  51. ncbi Towards remote evaluation of movement disorders via smartphones
    N Kostikis
    Department of Applied Informatics, University of Macedonia, Thessaloniki 54006, Greece
    Conf Proc IEEE Eng Med Biol Soc 2011:5240-3. 2011
    ..the availability of what is essentially a cheap, ubiquitous networked sensor, is that of remote diagnosis of movement disorders, such as Parkinson's disease...
  52. ncbi Are abnormal fidgety movements an early marker for complex minor neurological dysfunction at puberty?
    Christa Einspieler
    Institute of Physiology, Center for Physiological Medicine, Medical University of Graz, Harrachgasse 21 5, A 8010 Graz, Austria
    Early Hum Dev 83:521-5. 2007
    ..However, it is uncertain whether the GM assessment can be used to predict mild neurological impairment...
  53. ncbi Antibody binding to neuronal surface in movement disorders associated with lupus and antiphospholipid antibodies
    Russell C Dale
    Neuroimmunology Group, Institute of Neuroscience and Muscle Research, The Children s Hospital at Westmead, University of Sydney, Sydney, NSW, Australia
    Dev Med Child Neurol 53:522-8. 2011
    ..b>Movement disorders are rare neuropsychiatric complications of lupus and antiphospholipid syndrome, and autoimmune and ..
  54. ncbi Motor improvement and corticospinal modulation induced by hybrid assistive neuromuscular dynamic stimulation (HANDS) therapy in patients with chronic stroke
    Toshiyuki Fujiwara
    Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo
    Neurorehabil Neural Repair 23:125-32. 2009
    ....
  55. pmc Anti-basal ganglia antibodies: a possible diagnostic utility in idiopathic movement disorders?
    A J Church
    Neuroinflammation Department, Institute of Neurology, Queen Square, London, UK WC1N 3BG
    Arch Dis Child 89:611-4. 2004
    ..The spectrum of post-streptococcal brain disorders includes chorea, tics, and dystonia. The proposed mediators of disease are anti-basal ganglia (neuronal) antibodies (ABGA)...
  56. pmc A predictable worm: application of Caenorhabditis elegans for mechanistic investigation of movement disorders
    Paige M Dexter
    Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, USA
    Neurotherapeutics 9:393-404. 2012
    Ongoing investigations into causes and cures for human movement disorders are important toward the elucidation of diseases such as Parkinson's disease (PD) and dystonia...
  57. ncbi Movement disorders caused by medical disease
    Brandon Barton
    Department of Neurological Sciences, Movement Disorders Section, Rush University Medical Center, Chicago, Illinois 60612, USA
    Semin Neurol 29:97-110. 2009
    b>Movement disorders often occur in the context of medical illness, whether as the presenting sign of the illness, as a related feature of the underlying disease process, or as a complication of treatment...
  58. ncbi Prevalence of spontaneous dyskinesia in schizophrenia
    W S Fenton
    Chestnut Lodge Hospital, Rockville, MD 20850, USA
    J Clin Psychiatry 61:10-4. 2000
    ..Relative to the incidence and accrued prevalence of spontaneous dyskinesia expected during the natural history of untreated schizophrenia, the cumulative impact of treatment with new neuroleptic agents has yet to be determined...
  59. ncbi Movement disorders and pregnancy: a review of the literature
    Sarah M Kranick
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mov Disord 25:665-71. 2010
    Pregnant patients are rarely encountered in the movement disorders clinic, but they present significant dilemmas regarding treatment and counseling for neurologists...
  60. ncbi Movement disorders and neurochemical changes in zebrafish larvae after bath exposure to fluoxetine (PROZAC)
    Mark J Airhart
    Department of Anatomy and Cell Biology, P O Box 70582, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 1708, USA
    Neurotoxicol Teratol 29:652-64. 2007
    ..These results suggest a correlation between decreased concentration of SERT and 5-HT(1A) receptor transcripts in spinal cord and decreased SSA subsequent to fluoxetine exposure...
  61. ncbi Coping strategies and IQ in psychogenic movement disorders and paralysis
    M van Beilen
    Department of Neurology, University Medical Center Groningen, University of Groningen, The Netherlands
    Mov Disord 24:922-5. 2009
    ..Low active coping is not the result of low IQ and is not specific for psychogenic symptoms. At least part of the lower coping skills reported in patients with psychogenic symptoms may be the result of having an illness in general...
  62. ncbi Pathophysiology of the basal ganglia and movement disorders: from animal models to human clinical applications
    Zvi Israel
    Department of Neurosurgery, Hadassah University Hospital, Jerusalem, Israel
    Neurosci Biobehav Rev 32:367-77. 2008
    ..Here, we review the main insights learned from microelectrode physiological studies of MPTP monkeys over the last 20 years since the introduction of this animal model...
  63. ncbi Functional neurosurgery for movement disorders: a historical perspective
    Alim Louis Benabid
    CEA Minatec LETI and INSERM, Joseph Fourier University, Grenoble, France
    Prog Brain Res 175:379-91. 2009
    ..In the meantime, movement disorders, and particularly parkinsonian and essential tremors, were treated by electrolytic or mechanic lesions in ..
  64. ncbi Botulinum toxin: clinical use
    Daniel D Truong
    The Parkinson s and Movement Disorder Institute, 9940 Talbert Avenue, Fountain Valley, CA 92708, USA
    Parkinsonism Relat Disord 12:331-55. 2006
    ..Many other indications are currently under investigation, including gastroenterologic and urologic indications, analgesic management and migraine. This paper is an extensive review of the spectrum of BoNT clinical applications...
  65. ncbi Apraxia in movement disorders
    Cindy Zadikoff
    Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Brain 128:1480-97. 2005
    ..skilled movements cannot be explained by the more elemental motor disorders typical of patients with movement disorders. Generally this does not present a significant diagnostic problem when dealing with 'higher-level' praxic ..
  66. ncbi Psychogenic movement disorders
    Amitabh Gupta
    Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Neurol 22:430-6. 2009
    This review summarizes the progress made in the area of psychogenic movement disorders (PMDs) over the past 2 years, and a simplified classification of diagnostic certainty is proposed that incorporates electrophysiological assessment.
  67. ncbi Diagnosis and classification of chronic low back pain disorders: maladaptive movement and motor control impairments as underlying mechanism
    Peter O'Sullivan
    Body logic Physiotherapy, 146 Salvado Rd, Wembley, WA 6014, Australia
    Man Ther 10:242-55. 2005
    ..Although growing evidence exists to support this approach, further research is required to fully validate it...
  68. pmc Review of the possible relationship and hypothetical links between attention deficit hyperactivity disorder (ADHD) and the simple sleep related movement disorders, parasomnias, hypersomnias, and circadian rhythm disorders
    Arthur S Walters
    New Jersey Neuroscience Institute at JFK Medical Center, Seton Hall University School of Graduate Medical Education, Edison, NJ, USA
    J Clin Sleep Med 4:591-600. 2008
    ..not only disrupted in a nonspecific way but that ADHD has an increased association with simple sleep related movement disorders such as restless legs syndrome/periodic limb movements in sleep (RLS/PLMS), rhythmic movement disorder (body ..
  69. ncbi Bilateral slowing of mentally simulated actions after stroke
    Francine Malouin
    Center for interdisciplinary research in rehabilitation and social integration CIRRIS, IRDPQ, 525 Blvd Hamel east, Quebec City, P Q, Canada, G1M 2S8
    Neuroreport 15:1349-53. 2004
    ....
  70. ncbi Action observation has a positive impact on rehabilitation of motor deficits after stroke
    Denis Ertelt
    Department of Neurology and Neuroimage Nord, University Hospital Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Neuroimage 36:T164-73. 2007
    ....
  71. ncbi Movement disorders in patients with multiple sclerosis
    Natalya Shneyder
    Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Handb Clin Neurol 100:307-14. 2011
    ..A review of the literature in multiple sclerosis reveals case reports of a variety of other movement disorders such as myoclonus, spasmodic torticollis, paroxysmal dystonia, chorea, ballism, and parkinsonism...
  72. pmc Alien hand syndrome: neural correlates of movements without conscious will
    Michael Schaefer
    Department of Neurology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    PLoS ONE 5:e15010. 2010
    ..This study aimed to examine neural correlates of this rare neurological disorder in a patient with corticobasal degeneration and alien hand syndrome of the left hand...
  73. ncbi Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders
    David R P Guay
    Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Am J Geriatr Pharmacother 8:331-73. 2010
    Few drugs are available for the management of hyperkinetic movement disorders such as the dystonias, choreas, dyskinesias, and tics...
  74. ncbi Deep brain stimulation for movement disorders
    Kelly L Collins
    Department of Neurosurgery, University of Michigan Medical Center, 1500 E Medical Center Drive, SPC 5338, Ann Arbor, MI 48109 5338, USA
    Neurobiol Dis 38:338-45. 2010
    Deep brain stimulation (DBS) is a widely employed therapeutic modality for the treatment of movement disorders. Full FDA approval or humanitarian device exemption has been made for Parkinson's disease, tremor, and dystonia...
  75. ncbi The pedunculopontine nucleus: its role in the genesis of movement disorders
    M S Lee
    Department of Neurology, Yongdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
    Yonsei Med J 41:167-84. 2000
    ....
  76. pmc Pathological basal ganglia activity in movement disorders
    T Wichmann
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Neuroscience 198:232-44. 2011
    Our understanding of the pathophysiology of movement disorders and associated changes in basal ganglia activities has significantly changed during the last few decades...
  77. ncbi PET functional imaging of deep brain stimulation in movement disorders and psychiatry
    Benedicte Ballanger
    PET Imaging Centre, Center of Addiction Mental Health, University of Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 29:1743-54. 2009
    Deep brain stimulation (DBS) represents a major advance in the treatment of various severe movement disorders or neuropsychiatric diseases...
  78. pmc Oscillations in sensorimotor cortex in movement disorders: an electrocorticography study
    Andrea L Crowell
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA, USA
    Brain 135:615-30. 2012
    b>Movement disorders of basal ganglia origin may arise from abnormalities in synchronized oscillatory activity in a network that includes the basal ganglia, thalamus and motor cortices...
  79. ncbi Meta-analysis of neutralizing antibody conversion with onabotulinumtoxinA (BOTOX®) across multiple indications
    Markus Naumann
    Department of Neurology, Klinikum Augsburg Neurologische Klinik, Augsburg, Germany
    Mov Disord 25:2211-8. 2010
    ..Based on these large trials, the frequency of antibody conversion after onabotulinumtoxinA treatment is very low, and infrequently leads to loss of efficacy. © 2010 Movement Disorder Society...
  80. ncbi Movement disorders after resuscitation from cardiac arrest
    Arun Venkatesan
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neurol Clin 24:123-32. 2006
    ..Although rare, several movement disorders may arise as a consequence of hypoxic injury, including myoclonus, dystonia, akinetic-rigid syndromes, ..
  81. ncbi Movement disorders in musicians
    Joseph Jankovic
    Parkinson s Disease Center, Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mov Disord 23:1957-65. 2008
    ..of this article is to review the epidemiology, phenomenology, pathophysiology, genetics, and treatment of movement disorders, particularly task-specific dystonia, in musicians...
  82. ncbi Opinions and clinical practices related to diagnosing and managing patients with psychogenic movement disorders: An international survey of movement disorder society members
    Alberto J Espay
    Movement Disorders Center, Department of Neurology, University of Cincinnati College of Medicine, Ohio 45267 0525, USA
    Mov Disord 24:1366-74. 2009
    ..Disorder Society completed a 22-item questionnaire probing diagnostic and management issues in psychogenic movement disorders (PMD)...
  83. ncbi Movement disorders in Japanese encephalitis
    U K Misra
    Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Neurol 244:299-303. 1997
    b>Movement disorders in Japanese encephalitis (JE), although reported, have not been analyzed systematically. In this study, we report an analysis of movement disorders in 14 out of 17 JE patients, correlated with the radiological findings...
  84. ncbi Lack of conscious recognition of one's own actions in a haptically deafferented patient
    Pierre Fourneret
    Institut des Sciences Cognitives, 67 Boulevard Pinel, 69675 Bron Cedex, France
    Neuroreport 13:541-7. 2002
    ..We suggest that information derived from efferent processes cannot in themselves be a source for conscious experience about our own actions...
  85. pmc Physiology of psychogenic movement disorders
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, Building 10, Room 7D37, 10 Center Drive MSC 1428, Bethesda, Maryland 20892 1428, USA
    J Clin Neurosci 17:959-65. 2010
    Psychogenic movement disorders (PMDs) are common, but their physiology is largely unknown...
  86. ncbi Moving with or without will: functional neural correlates of alien hand syndrome
    Frederic Assal
    Neurology Clinic, Department of Clinical Neurosciences, University Hospital, Geneva, Switzerland
    Ann Neurol 62:301-6. 2007
    ....
  87. ncbi Systematic review of paramedical therapies for Parkinson's disease
    Katherine H O Deane
    Department of Neurology, City Hospital NHS Trust, and The University of Birmingham, Birmingham, United Kingdom
    Mov Disord 17:984-91. 2002
    ..However, this lack of evidence is not proof of a lack of effect. Further large pragmatic randomised controlled trials are required to determine the effectiveness of paramedical therapies in Parkinson's disease...
  88. ncbi Psychogenic movement disorders
    Vanessa K Hinson
    Department of Neurosciences, Murray Center for Research on Parkinson s Disease and Related Disorders, Medical University of South Carolina, Charleston Memorial Hospital, Charleston, SC 29425, USA
    Lancet Neurol 5:695-700. 2006
    Diagnosis and treatment of psychogenic movement disorders are challenging for both neurologists and psychiatrists...
  89. ncbi Psychogenic movement disorders: a crisis for neurology
    Mark Hallett
    Human Motor Control Section, NINDS NIH, Building 10, Room 5N226, 10 Center Drive, MSC 1428, Bethesda, MD 20892 1428, USA
    Curr Neurol Neurosci Rep 6:269-71. 2006
  90. ncbi GABAergic circuits in the basal ganglia and movement disorders
    Adriana Galvan
    Department of Neurology, School of Medicine and Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
    Prog Brain Res 160:287-312. 2007
    ..not surprising that abnormalities of GABAergic transmission are key elements in pathophysiologic models of movement disorders involving the basal ganglia...
  91. ncbi Chronic motor cortex stimulation for movement disorders: a promising perspective
    Angelo Franzini
    Department of Neurosurgery, Istituto Nazionale Neurologico C Besta, Via Celoria, 11 20133 Milano, Italy
    Neurol Res 25:123-6. 2003
    ..No complications or undesired side effects of electrode implant and stimulation were observed...
  92. ncbi Modeling movement disorders--CRPS-related dystonia explained by abnormal proprioceptive reflexes
    Winfred Mugge
    Laboratory for Neuromuscular Control, Department of Biomechanical Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft, The Netherlands
    J Biomech 45:90-8. 2012
    ..reflexes and biomechanical properties of the limb is essential in understanding the etiology of movement disorders. A non-linear neuromuscular model of the wrist incorporating muscle dynamics and neural control was ..
  93. ncbi The role of DAT-SPECT in movement disorders
    G Kägi
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, National Hospital for Neurology and Neurosurgery, London, UK
    J Neurol Neurosurg Psychiatry 81:5-12. 2010
    ..This review addresses the value of DAT-SPECT and its impact on diagnostic accuracy in movement disorders presenting with tremor and/or parkinsonism.
  94. ncbi In vivo imaging of synaptic function in the central nervous system: I. Movement disorders and dementia
    Susanne Nikolaus
    Clinic of Nuclear Medicine, University Hospital Dusseldorf, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    Behav Brain Res 204:1-31. 2009
    ..in vivo imaging studies on synaptic neurotransmission, which so far have been performed on patients with movement disorders and/or dementia...
  95. ncbi Movement disorders in autoimmune diseases
    José Fidel Baizabal-Carvallo
    Parkinson s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas, USA
    Mov Disord 27:935-46. 2012
    b>Movement disorders have been known to be associated with a variety of autoimmune diseases, including Sydenham's chorea, pediatric autoimmune neuropsychiatric disorders associated with streptococcus, systemic lupus erythematosus, ..
  96. ncbi Surgical treatment of cervical myeloradiculopathy associated with movement disorders: indications, technique, and clinical outcome
    Albert S Wong
    Division of Neurosurgery, University of Toronto, and Spinal Program, Krembil Neuroscience Center, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    J Spinal Disord Tech 18:S107-14. 2005
    b>Movement disorders may be associated with advanced cervical myeloradiculopathy, which represents a major management challenge...
  97. ncbi Botulinum toxin for the treatment of movement disorders
    Mary Ann Thenganatt
    Department of Neurology, College of Physicians and Surgeons, Columbia University, 710 West 168th Street, New York, NY 10032, USA
    Curr Neurol Neurosci Rep 12:399-409. 2012
    After botulinum toxin was initially used to treat strabismus in the 1970s, others started using it to treat movement disorders including blepharospasm, hemifacial spasm, cervical dystonia, spasmodic dysphonia, and oromandibular dystonia...
  98. ncbi Persistent movement disorders following Japanese encephalitis
    U A Murgod
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Neurology 57:2313-5. 2001
    The authors report on movement disorders that persist for a long duration following Japanese encephalitis (JE). Fifteen patients with diagnosed JE were followed up after an interval of 3 to 5 years...
  99. ncbi Sensorimotor integration: basic concepts, abnormalities related to movement disorders and sensorimotor training-induced cortical reorganization
    Sergio Machado
    Cartografía Cerebral e Integración Sensitivomotora, Instituto de Psiquiatria, Universidad Federal de Rio de Janeiro, IPUB UFRJ, Brasil
    Rev Neurol 51:427-36. 2010
    ..Sensorimotor integration is defined as the capability of the central nervous system to integrate different sources of stimuli, and parallelly, to transform such inputs in motor actions...
  100. ncbi Cranial movement disorders: clinical features, pathophysiology, differential diagnosis and treatment
    Giovanni Fabbrini
    Movement Disorders Clinic, Department of Neurosciences and Neuromed Institute, Sapienza University of Rome, Rome
    Nat Clin Pract Neurol 5:93-105. 2009
    Cranial movement disorders are a common neurological problem. These disorders can be limited to the cranial muscles alone or manifest as part of a more generalized movement disorder...

Research Grants79

  1. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
    ..will be obtained will be of general value in understanding the genetic structure of the extrapyramidal system which in turn will help our understanding of movement disorders that are prevalent in the VA population, such a Parkinsonism.
  2. Exome re-sequencing candidate loci for familial essential tremor
    Barry E Kosofsky; Fiscal Year: 2012
    ..Studying the untoward effects of mutant ET genes will increase our knowledge of ET and other movement disorders such as Parkinson disease.
  3. Dopamine D1 Receptor in mouse models of primary dystonia
    Laurie J Ozelius; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Primary torsion dystonias (PTD) are a group of movement disorders characterized by twisting muscle contractures, with dystonia as the only clinical sign (except for tremor) and in the absence of ..
  4. Multi-Organ Autonomic Electrophysiology in Parkinson Disease
    Samay Jain; Fiscal Year: 2013
    ..D., M.S. is a junior faculty member in the University of Pittsburgh, Department of Neurology Movement Disorders Division since 2006. In 2007, Dr...
  5. Role of G-gamma-7 in striatal cannabinoid and D2 dopamine
    Dana E Selley; Fiscal Year: 2010
    ..These studies will provide information that contributes to our understanding of the neural mechanisms of drug addiction and possibly neuropsychiatric and movement disorders, such as schizophrenia and Parkinsonism.
  6. Improving Quality of Care in Parkinsons Disease: A Randomized Controlled Trial
    KAREN ILENE CONNOR; Fiscal Year: 2013
    ..Centers (PADRECC) were established a decade ago to provide subspecialty care within VA for PD and other movement disorders, but there are inadequate numbers of subspecialists to provide care to all veterans with PD...
  7. A Phase II Trial of Levodopa in Angelman Syndrome
    Wen Hann Tan; Fiscal Year: 2013
    ..by applicant): This study will investigate the efficacy of levodopa in improving the neurodevelopment and movement disorders in children with Angelman Syndrome (AS), a rare neurodevelopmental disorder with a prevalence of ..
  8. BRAIN LIPID METABOLISM, DENDRITES AND SYNAPSES IN AGING AND ALZHEIMER'S DISEASE
    Guojun Bu; Fiscal Year: 2013
    ..LRP1-KO mice have memory deficits and movement disorders consistent with compromised dendritic spine/synaptic integrity and synaptic functions...
  9. RTP801 and ATF4 in Neuronal Death in PD
    OREN ABRAHAM LEVY; Fiscal Year: 2013
    ..Next, I came to Columbia for fellowship training in movement disorders. I have developed my clinical skills in caring for patients with movement disorders, primarily Parkinson&..
  10. Udall Parkinson's Disease Center at Emory University: Circuitry to Therapy
    THOMAS N WICHMANN; Fiscal Year: 2013
    ..Other Center assets will be its close ties to the clinical movement disorders group at Emory, the fact that a portion of the research will be carried out in primates at the Yerkes ..
  11. Phenotypic Spectrum of LRRK2 Mutations
    Rachel Saunders-Pullman; Fiscal Year: 2013
    ..I have extensive training in movement disorders and epidemiology, and have published on LRRK2 PD, Gaucher associated PD, and biomarkers associated with PD, ..
  12. The Biosynthesis of Anandamide
    Dale G Deutsch; Fiscal Year: 2010
    ..such diverse functions as reinforcement, mood, memory, appetite, pain and movement, understanding how it is synthesized may lead to treatment for drug addiction, depression, compulsive behaviors, neuropathic pain and movement disorders.
  13. Endocannabinoid Intracellular Transporters
    Dale G Deutsch; Fiscal Year: 2010
    ..such diverse functions as reinforcement, mood, memory, appetite, pain and movement;drugs that prevent their inactivation may be good for treating drug addiction, depression, compulsive behaviors, neuropathic pain and movement disorders.
  14. Clinical center for the study of neuroprotection from PD
    Joseph Jankovic; Fiscal Year: 2013
    ..This requires coordination of care across specialties as well as within Movement Disorders. As examples, we are currently working with a participant who had had 2 coronary stents placed recently, but ..
  15. Aerobic Exercise, Neurotrophins, and fMRI of Hippocampal Function and Structure
    Karin Schon; Fiscal Year: 2011
    ..Wagenaar, Ph.D., a professor of exercise physiology and neurorehabilitation who is known for his work on movement disorders, Dr. Andrew E. Budson, M.D...
  16. Local Circuit Properties of Mouse Corticospinal Neurons
    Patrick L Sheets; Fiscal Year: 2011
    ..primary motor cortex (M1) causes major neurological impairment including paralysis/paraplegia, epilepsy, and movement disorders including amyotrophic lateral sclerosis (ALS), a disease affecting upper motor neurons...
  17. Advanced technology for neural interfaces based on microstimulation
    DOUGLAS BUCHANAN MCCREERY; Fiscal Year: 2013
    ..to the individual stimulus pulses, and may find other uses in clinical medicine, including treatment of movement disorders. In a study just completed, we found that encoding of amplitude modulation by microstimulation in the ..
  18. GABA channels and dopamine in striatum
    Stefano Vicini; Fiscal Year: 2013
    ..neurons are the major output neurons from the mammalian striatum, control movements and become imbalanced in movement disorders. Previous reports have suggested that dopamine depletion induces changes in GABA receptors which exacerbate ..
  19. Brain Matters 3: Values at the Crossroads of Neurology, Psychiatry, and Psycholog
    PAUL JASON FORD; Fiscal Year: 2012
    ..These diagnoses include, but are not limited to, chronic pain disorders, psychogenic movement disorders, conversion disorders, post traumatic stress disorder, and fibromyalgia...
  20. The Effect of Low Frequency STN DBS on Sleep and Vigilance in PD Patients
    AMY WILLIS AMARA; Fiscal Year: 2013
    ..Her subsequent clinical residency training in neurology and fellowship training in both Movement Disorders and Sleep Medicine provide a framework upon which this proposal and her career can grow...
  21. Behavioral therapy to treat urinary symptoms in Parkinson's disease
    ELIZABETH CAMILLE VAUGHAN; Fiscal Year: 2012
    ..Burgio, PhD (behavioral psychology), and Jorge L. Juncos, MD (movement disorders). Advisors: Gerald McGwin, PhD (biostatistics) and Felicia Goldstein, PhD (neuropsychology)...
  22. High Sensitivity Mobile PET for Brain Imaging and Proton Therapy Monitoring
    Georges El Fakhri; Fiscal Year: 2010
    ..diseases such as Alzheimer's disease, Parkinson Disease with Dementia and Lewy Body Dementia, in movement disorders and in psychiatric disorders such as obsessive compulsive disorders and post traumatic stress disorders and ..
  23. Characterization of Striatal Nitric Oxide Signaling
    Anthony West; Fiscal Year: 2009
    ..these studies may reveal novel drug targets within cyclic nucleotide signaling cascades for treating movement disorders including akinesia and L-DOPA-induced dyskinesias which are associated with abnormal corticostriatal ..
  24. Neuroimaging for Early Diagnosis of Manganese Toxicity in Humans and Rodents
    Ulrike Dydak; Fiscal Year: 2013
    ..the neurotransmitter 3-aminobutyric acid (GABA) in the basal ganglia brain region, similar to those found in movement disorders. However the dose-dependency, specificity and the mechanism underlying these alterations is unknown...
  25. The Impact of Deep Brain Stimulation on Frontal-Subcortical Emotional Processing
    Joseph S Neimat; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The basal ganglia have long been known to play an important role in movement disorders. These nuclei have been important targets to the surgical treatment of Parkinson's disease (PD) and other ..
  26. Glutamate, aging and enriched environment after dopamine loss
    CHARLES KENNETH MESHUL; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Investigation of movement disorders, especially Parkinson's disease, is a high priority research area within the Department of Veterans ..
  27. Lipidomic profile of endocannabinoids from neuronal cells
    VINCENT JO DAVISSON; Fiscal Year: 2010
    ..manipulation of this system has potentially therapeutic effects in such conditions as convulsions, glaucoma, movement disorders, anxiety, obesity, and multiple sclerosis...
  28. PEROMYSCUS LABORATORY MODELS FOR BIOMEDICAL RESEARCH
    Gabor Szalai; Fiscal Year: 2013
    ..enhance the importance of Peromyscus as a research tool in areas of gene discovery in the area of repetitive movement disorders, juvenile and adult ataxia, and epilepsy, gene expression in disease and environmental toxicology, and ..
  29. Adult Neurological Phenotypes of Fragile X Gray Zone Expansion
    Deborah A Hall; Fiscal Year: 2013
    ..This project will determine: 1) the association of FMR1 gray zone expansions and the presence of movement disorders and cognitive deficits in a community based sample, 2) the relationship of loss of normal AGG interspersions ..
  30. Prevalence of FMRI Expansions in Movement Disorders
    Deborah A Hall; Fiscal Year: 2010
    Dr. Deborah Ann Hall is applying for a mentored patient-oriented research (K23) award in the area of movement disorders. This proposal describes a research and training program for the development of a clinician-investigator in neurology...
  31. Aerobic Exercise, Neurotrophins, and fMRI of Hippocampal Function and Structure
    Karin Schon; Fiscal Year: 2013
    ..Wagenaar, Ph.D., a professor of exercise physiology and neurorehabilitation who is known for his work on movement disorders, Dr. Andrew E. Budson, M.D...
  32. Effects of octanoic acid for treatment of essential voice tremor
    SOREN YVETTE LOWELL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Essential tremor is among the most common movement disorders, affecting nearly 5% of people over the age of 65...
  33. ROLE OF DOPAMINE RECEPTORS IN PRIMARY FOCAL DYSTONIAS
    Morvarid Karimi; Fiscal Year: 2013
    ..I have received clinical training in Movement Disorders under Dr...
  34. In Vivo Reconstitution Models for NeuroAIDS and Beta-Amyloidosis
    Tsuneya Ikezu; Fiscal Year: 2010
    ..with HIV abound, including cognitive dysfunction (HIV associated dementia, HAD, and minor cognitive movement disorders, MCMD, among others) seen during the later stages of the disease...
  35. Cortical Control of Hindlimb Muscles in Primates
    PAUL DAVID CHENEY; Fiscal Year: 2012
    ..of cortical organization have been shown to relate directly to normal movement as well as aspects of movement disorders in conditions such as stroke and cerebral palsy...
  36. Regulation of basal ganglia output neurons
    Fu Ming Zhou; Fiscal Year: 2012
    ..control circuit and the pathophysiology of PD and provide a potential route for therapeutic intervention in movement disorders of basal ganglia origin such as PD...
  37. Non-invasive Markers of Neurodegeneration in Movement Disorders
    David E Vaillancourt; Fiscal Year: 2013
    ..Other movement disorders that commonly mimic symptoms of PD include the Parkinsonian variant of multiple system atrophy (MSA), ..
  38. Aging the Central Nervous System and Mobility in Older Adults
    Stephanie A Studenski; Fiscal Year: 2013
    ..g., Neurology, Gait &Posture, Behavioral and Brain Functions, Movement Disorders, Journal of Gerontology: Medical Sciences, Frontiers in Aging Neuroscience, etc.) for publication...
  39. Cortical and basal ganglia local field potentials in human movement disorders
    Philip A Starr; Fiscal Year: 2012
    Abstract The goal of this project is to advance the understanding of movement disorders pathophysiology through studies of basal ganglia and cortical local field potentials (LFPs) in humans...
  40. Parkinson Disease Disparities and Outcomes
    Allison Wright Willis; Fiscal Year: 2013
    ..I am an Assistant Professor of Neurology and Movement Disorders Specialist at Washington University School of Medicine in St. Louis, MO...
  41. Pontine motor circuits
    Jun Lu; Fiscal Year: 2013
    ..relays basal ganglia output to spinal motor cord circuitry, therapeutic and diagnostic strategies may be developed for individuals suffering from Parkinsonism and possibly other movement disorders such as cataplexy.
  42. Organization and Function of Striatal Microcircuits in Health and Disease
    ARYN HILARY GITTIS; Fiscal Year: 2012
    ..Imbalances between these two pathways are hypothesized to underlie movement disorders such as Parkinson's disease, Huntington's disease, Tourette syndrome, and dystonia...
  43. Organization and Function of Striatal Microcircuits in Health and Disease
    ARYN HILARY GITTIS; Fiscal Year: 2013
    ..Imbalances between these two pathways are hypothesized to underlie movement disorders such as Parkinson's disease, Huntington's disease, Tourette syndrome, and dystonia...
  44. Interdisciplinary Training in Pathobiology and Rehabilitation Medicine
    Marcas M Bamman; Fiscal Year: 2013
    ..Training ill occur in one of two areas of concentrated strength: 1) Neuromusculo- skeletal and Movement Disorders;or 2) Cardiopulmonary and Metabolic Diseases...
  45. EXPERIMENTAL THERAPEUTICS IN NEUROLOGICAL DISEASE
    Robert C Griggs; Fiscal Year: 2013
    ..draws on strengths of 1) clinical neuroscientists with investigative programs in neuromuscular disease, movement disorders, multiple sclerosis, dementia, epilepsy, stroke, and AIDS;(2) integration with Biostatistics faculty;(3)..
  46. Targeting physiologic changes as a route towards therapy for degenerative ataxias
    VIKRAM GOVINDARAJU SHAKKOTTAI; Fiscal Year: 2013
    ..faculty position at a neurology department at a major institution, combining the care of patients with movement disorders and heading a research laboratory that continues to interrogate the role of ion-channels in the pathogenesis ..
  47. Elucidating and understanding the genetic basis of movement disorders
    Coro Paisan-Ruiz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Complex movement disorders (CMDs), defined as disorders in which patients are affected by more than one movement disorder (such as parkinsonism and dystonia, or myoclonus and tremor), are a continuing ..
  48. STRUCTURE AND FUNCTION OF POTASSIUM CHANNELS
    Brad S Rothberg; Fiscal Year: 2010
    ..as well as smooth muscle contractility, and consequently, dysfunction of BK channels is associated with movement disorders and epilepsy in humans, and with hypertension in mouse models...
  49. Optimizing communication devices for children with dyskinetic cerebral palsy
    Terence D Sanger; Fiscal Year: 2012
    ..For children with dyskinetic cerebral palsy (CP and severe arm movement disorders, devices such as adapted keyboards, programmable touch-screens, and joystick interfaces may be their most ..
  50. Accuracy of Examining Cough Function and its Relationship to Airway Protection
    Christine M Sapienza; Fiscal Year: 2013
    ..Participants with PD will be recruited from the University of Florida Movement Disorders Center...
  51. Accuracy of Examining Cough Function and its Relationship to Airway Protection
    CHRISTINE M contact SAPIENZA; Fiscal Year: 2010
    ..Participants with PD will be recruited from the University of Florida Movement Disorders Center...
  52. Circadian Rhythms and Sleep-Wake Cycles in Parkinson's Disease
    Aleksandar Videnovic; Fiscal Year: 2013
    ..Aleksandar Videnovic with the research skills and experience to bridge the areas of movement disorders, sleep and circadian biology in order to understand the basis for sleep and wake disturbances in PD. Dr...
  53. Genetic Control of Basal Telencephalic Development
    John L R Rubenstein; Fiscal Year: 2013
    ..Disruption of these mechanisms can cause psychiatric and neurological disorders that include mental retardation, autism, schizophrenia, movement disorders and addiction.
  54. DBS of the pedunculopontine nucleus in Parkinsonian primate
    Jerrold L Vitek; Fiscal Year: 2010
    ..As a treatment of gait dysfunction, the utility of PPN DBS may extend beyond the PD population to other movement disorders, including progressive supranuclear palsy and multiple systems atrophy.
  55. Metabotropic glutamate receptor-mediated synaptic plasticity in the basal ganglia
    KARI JOHNSON; Fiscal Year: 2012
    ..Disruption of basal ganglia function causes devastating movement disorders such as Parkinson's disease (PD)...
  56. M1 and M4 mAChRs in striatum-implication in treatment of movement disorders
    Zixiu Xiang; Fiscal Year: 2013
    ..and pathophysiological functions in the striatum and provide the basis for the development of improved anticholinergic therapies for PD, dystonia and other movement disorders that could be devoid of the severe adverse effects.
  57. The role of UCHL1 on the health and stability of upper motor neurons
    Pembe Hande Ozdinler; Fiscal Year: 2013
    ..Mutations in the UCHL1 gene is linked both to movement disorders in patients with Parkinson's disease, and more recently in early neurodegeneration which involves the ..
  58. Chemical probes of the astroglial potassium channel Kir4.1
    Jerod S Denton; Fiscal Year: 2012
    ..These studies may lay the foundation for the development of novel drugs to treat cancer, movement disorders and high blood pressure...
  59. Optogenetic dissection of striatal circuits in a mouse model of human dystonia
    Alexandra Nelson; Fiscal Year: 2013
    ..we hope to identify new targets for therapeutic development in dystonia as well as other hyperkinetic movement disorders. We propose to use several novel tools to better understand circuit dysfunction in dystonia...
  60. Dentatothalamocortical electrical stimulation in post-stroke motor recovery
    Andre Guelman Machado; Fiscal Year: 2013
    ..given that the technology for deep brain stimulation (DBS) is already FDA approved for the treatment of movement disorders and has been proven safe in over 40,000 implants...
  61. Molecular Control of Na+ Channel Density and Localization in Myelinated Axons
    Lori L Isom; Fiscal Year: 2013
    ..Preliminary Data demonstrate that mice that lack Scn1b in myelinating glia have movement disorders, dysmyelination, delayed myelination or lack of myelination, and axonal degeneration...
  62. Longitudinal multi-modality imaging in progressive apraxia of speech
    JENNIFER LOUISE WHITWELL; Fiscal Year: 2013
    ..She will also have support from a team of world renowned scientists including dementia, movement disorders and speech pathology specialists, a nuclear medicine scientist, neuropsychologists, and biostatisticians...
  63. EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Curt Freed; Fiscal Year: 2005
    ..The PI is at U CO Health Sciences; the second center is the Movement Disorders Unit at Columbia Presbyterian Medical Center in NY (Stanley Fahn)...
  64. GENETIC ANALYSIS OF PAROXYSMAL DYSTONIC CHOREOATHETOSIS
    John Fink; Fiscal Year: 2000
    DESCRIPTION (modified from the principal investigator's application): Involuntary movement disorders are a major cause of disability...
  65. PALLIDAL PHYSIOLOGY IN HUMAN AND PRIMATE DYSTONIA
    PHILIP STARR; Fiscal Year: 2005
    ..Recently, attempts have been made to understand movement disorders in terms of alterations in a loop circuit involving the cortex, basal ganglia and thalamus...
  66. PET IN HYPERKINETIC DISORDERS--A MULTICENTER STUDY
    David Eidelberg; Fiscal Year: 2001
    Idiopathic torsion dystonia (ITD) and Huntington's disease (HD) are common hereditary hyperkinetic movement disorders affecting the basal ganglia...
  67. Functional Studies of Subtypes of Parkinson's Diseasee
    Xuemei Huang; Fiscal Year: 2007
    ..disease (PD), and allow the applicant to develop expertise in using functional MRI (fMRI) as a tool to study movement disorders. The primary mentor of this work will be Dr...
  68. GROWTH OF OPTIC NERVE FIBERS
    Robert Williams; Fiscal Year: 1999
    ..poor foveal development, severe deficits in visual acuity, loss of binocular vision, strabismus, and eye movement disorders. For these reasons it is critical to know more about the mechanisms responsible for generating precise ..
  69. NIH-BIOMECHANICS IN MOVEMENT SCIENCE: BUILDING TRANSDOMAIN BRIDGES
    Irene S Davis; Fiscal Year: 2010
    ..Sciences is well poised to enhance the understanding of the broad array of neurologic and orthopedic human movement disorders. This requires integration of knowledge from the mechanics of cells and tissues, to joints, limbs, and even ..
  70. ON-OFF MOOD CHANGE IN PARKINSONS DISEASE
    Kevin Black; Fiscal Year: 2000
    ..clinical and research experience to a productive research career focused on the functional neuroanatomy of movement disorders. This is seen as a natural extension of the applicant's prior research experience, and his longstanding ..
  71. SUBSTANTIA NIGRA IN MOVEMENT AND MOVEMENT DISORDERS
    Thomas Wichmann; Fiscal Year: 2000
    ..A. 4). With the hypothesis that abnormal discharge in SNr contributes to Parkinsonian motor signs, it is expected that inactivation of SNr will ameliorate the motor disturbances, and that effects of GPi and SNr lesions will be additive. ..
  72. Neostriatal Visual Processing & Initiation of Movement
    Emad Eskandar; Fiscal Year: 2005
    ..Disorders of the basal ganglia lead to a variety of disabling movement disorders, the most common of which is Parkinson's disease...
  73. Two-photon calcium imaging of the effects of cortical microstimulation
    R Reid; Fiscal Year: 2009
    ..Similarly, deep brain stimulation has proven highly valuable in the treatment of intractable movement disorders including Parkinson's...
  74. BASAL GANGLIA GENE EXPRESSION AND MOVEMENT DISORDERS
    Kalpana Merchant; Fiscal Year: 1993
    ..The APD-induced movement disorders are clinically indistinguishable from their idiopathic counterparts...
  75. NEUROIMAGING OF HYPERKINETIC MOVEMENT DISORDERS
    Michael Hutchinson; Fiscal Year: 2001
    Despite recent progress, there is still uncertainty about the pathophysiology of movement disorders in man...
  76. Advanced Technology and Tools for DBS Programming for Speech Functionality
    Craig van Horne; Fiscal Year: 2009
    ..deep brain stimulation (DBS) has proven to be effective for motor problems in patients with PD and other movement disorders. However, the effects of DBS on speech have not been consistently positive...
  77. CEREBELLOTHALAMIC SYSTEM--MOTOR AND COGNITIVE CIRCUITS
    Igor Ilinsky; Fiscal Year: 1999
    ..Traditionally, VL has been implicated in manifestations of movement disorders such as Parkinsonian tremor and rigidity, but the mechanisms of this involvement remain unclear...
  78. Parkin function: Regulation of members of synaptotagmin
    Duong Huynh; Fiscal Year: 2009
    Parkinson's disease (PD) is a disabling movement disorders caused by reduced dopamine levels in the striatum resulting from the death of dopaminergic neurons in the substantia nigra...
  79. Cholinergic Enhancement of Human Cortical Plasticity
    Bruce Rosen; Fiscal Year: 2003
    ..opportunities for the remediation of several different neurological conditions, such as stroke-induced movement disorders, dystonia, and dyslexia...