cluster headache

Summary

Summary: A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial SWEATING, eyelid EDEMA, and miosis. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)

Top Publications

  1. ncbi Hypothalamic activation in cluster headache attacks
    A May
    University Department of Clinical Neurology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
    Lancet 352:275-8. 1998
  2. ncbi Cluster headache: aetiology, diagnosis and management
    Karl Ekbom
    Department of Neurology, Huddinge University Hospital, Huddinge, Sweden
    Drugs 62:61-9. 2002
  3. ncbi Cluster headache: a prospective clinical study with diagnostic implications
    Anish Bahra
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom
    Neurology 58:354-61. 2002
  4. ncbi Cluster headache in the United States of America: demographics, clinical characteristics, triggers, suicidality, and personal burden
    Todd D Rozen
    Geisinger Wyoming Valley Geisinger Health System, Department of Neurology, Wilkes Barre, PA 18711, USA
    Headache 52:99-113. 2012
  5. ncbi Sustained effectiveness of occipital nerve stimulation in drug-resistant chronic cluster headache
    Delphine Magis
    Headache Research Unit, CHR Citadelle, Department of Neurology, University of Liege, Liege, Belgium
    Headache 51:1191-201. 2011
  6. ncbi EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias
    A May
    Department of Systems Neuroscience, University of Hamburg, Hamburg, Germany
    Eur J Neurol 13:1066-77. 2006
  7. ncbi Suboccipital injection with a mixture of rapid- and long-acting steroids in cluster headache: a double-blind placebo-controlled study
    Anna Ambrosini
    Headache Clinic, INM Neuromed, IRCCS, Via Atinense, 18, I 86077 Pozzilli, Isernia, Italy
    Pain 118:92-6. 2005
  8. ncbi Diagnostic delays and mis-management in cluster headache
    A Bahra
    Headache Group, Institute of Neurology, Queen Square, London, UK
    Acta Neurol Scand 109:175-9. 2004
  9. pmc Central modulation in cluster headache patients treated with occipital nerve stimulation: an FDG-PET study
    Delphine Magis
    University Neurology Department, Liege, Belgium
    BMC Neurol 11:25. 2011
  10. pmc Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: a randomized, sham-controlled study
    Jean Schoenen
    Headache Research Unit, Department of Neurology, CHR Citadelle, Liege University, B 4000 Liege, Belgium
    Cephalalgia 33:816-30. 2013

Detail Information

Publications246 found, 100 shown here

  1. ncbi Hypothalamic activation in cluster headache attacks
    A May
    University Department of Clinical Neurology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
    Lancet 352:275-8. 1998
    b>Cluster headache, one of the most severe pain syndromes in human beings, is usually described as a vascular headache...
  2. ncbi Cluster headache: aetiology, diagnosis and management
    Karl Ekbom
    Department of Neurology, Huddinge University Hospital, Huddinge, Sweden
    Drugs 62:61-9. 2002
    b>Cluster headache is characterised by repeated attacks of strictly unilateral pain in the orbital region associated with local autonomic symptoms or signs. The attacks are brief but of a very severe, almost excruciating intensity...
  3. ncbi Cluster headache: a prospective clinical study with diagnostic implications
    Anish Bahra
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom
    Neurology 58:354-61. 2002
  4. ncbi Cluster headache in the United States of America: demographics, clinical characteristics, triggers, suicidality, and personal burden
    Todd D Rozen
    Geisinger Wyoming Valley Geisinger Health System, Department of Neurology, Wilkes Barre, PA 18711, USA
    Headache 52:99-113. 2012
    To present results from the United States (US) Cluster Headache Survey including data on cluster headache demographics, clinical characteristics, suicidality, diagnostic delay, triggers, and personal burden.
  5. ncbi Sustained effectiveness of occipital nerve stimulation in drug-resistant chronic cluster headache
    Delphine Magis
    Headache Research Unit, CHR Citadelle, Department of Neurology, University of Liege, Liege, Belgium
    Headache 51:1191-201. 2011
    Drug-resistant chronic cluster headache (drCCH) is a devastating condition for which various invasive therapeutic procedures have been tempted without any satisfactory effect...
  6. ncbi EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias
    A May
    Department of Systems Neuroscience, University of Hamburg, Hamburg, Germany
    Eur J Neurol 13:1066-77. 2006
    b>Cluster headache and the other trigeminal-autonomic cephalalgias [paroxysmal hemicrania, short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) syndrome] are rare but very disabling ..
  7. ncbi Suboccipital injection with a mixture of rapid- and long-acting steroids in cluster headache: a double-blind placebo-controlled study
    Anna Ambrosini
    Headache Clinic, INM Neuromed, IRCCS, Via Atinense, 18, I 86077 Pozzilli, Isernia, Italy
    Pain 118:92-6. 2005
    Oral steroids can interrupt bouts of cluster headache (CH) attacks, but recurrence is frequent and may lead to steroid-dependency...
  8. ncbi Diagnostic delays and mis-management in cluster headache
    A Bahra
    Headache Group, Institute of Neurology, Queen Square, London, UK
    Acta Neurol Scand 109:175-9. 2004
    b>Cluster headache is a stereotyped form of primary headache that while common in terms of neurologic illnesses is much less common as a cause of disabling headache than migraine.
  9. pmc Central modulation in cluster headache patients treated with occipital nerve stimulation: an FDG-PET study
    Delphine Magis
    University Neurology Department, Liege, Belgium
    BMC Neurol 11:25. 2011
    Occipital nerve stimulation (ONS) has raised new hope for drug-resistant chronic cluster headache (drCCH), a devastating condition. However its mode of action remains elusive...
  10. pmc Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: a randomized, sham-controlled study
    Jean Schoenen
    Headache Research Unit, Department of Neurology, CHR Citadelle, Liege University, B 4000 Liege, Belgium
    Cephalalgia 33:816-30. 2013
    The pain and autonomic symptoms of cluster headache (CH) result from activation of the trigeminal parasympathetic reflex, mediated through the sphenopalatine ganglion (SPG)...
  11. ncbi The misdiagnosis of cluster headache: a nonclinic, population-based, Internet survey
    J A Klapper
    Colorado Neurology and Headache Center, Denver 80218, USA
    Headache 40:730-5. 2000
    OBJECTIVE: We conducted the first nonclinic, Internet-based survey of cluster headache to investigate this population with regard to diagnostic problems encountered, effective and ineffective medications, problems obtaining medications ..
  12. ncbi Anatomical location of effective deep brain stimulation electrodes in chronic cluster headache
    Denys Fontaine
    Centre Hospitalier Universitaire de Nice Neurosurgery, Nice, France
    Brain 133:1214-23. 2010
    ..stimulation of the posterior hypothalamus is a therapeutic approach to the treatment of refractory chronic cluster headache, but the precise anatomical location of the electrode contacts has not been clearly assessed...
  13. pmc Features involved in the diagnostic delay of cluster headache
    J A van Vliet
    Department of Neurology, Leiden University Medical Centre, 2300 RC Leiden, Netherlands
    J Neurol Neurosurg Psychiatry 74:1123-5. 2003
    b>Cluster headache (CH) is a comparatively rare, very severe primary headache. Although circumscript and recognisable criteria are available, the diagnosis is often missed or delayed...
  14. ncbi Electrical stimulation of sphenopalatine ganglion for acute treatment of cluster headaches
    Mehdi Ansarinia
    The Headache Specialists, Las Vegas, NV, USA
    Headache 50:1164-74. 2010
    ..For this reason, it was selected as a target for an acute neurostimulation study...
  15. ncbi Diffusion tensor imaging in episodic cluster headache
    Michael Teepker
    Department of Neurology, Philipps University of Marburg, Marburg, Germany
    Headache 52:274-82. 2012
    b>Cluster headache (CH) is a rare headache disorder with severe unilateral headache bouts and autonomic symptoms. The pathophysiology of CH is not completely understood...
  16. ncbi Cranial autonomic symptoms in migraine: characteristics and comparison with cluster headache
    T H Lai
    Department of Neurology, National Yang Ming University, Taipei, Taiwan
    J Neurol Neurosurg Psychiatry 80:1116-9. 2009
    Cranial autonomic symptoms (CAS) are distinguishing features of trigeminal autonomic cephalalgias, of which cluster headache (CH) is the most common, but they can occur in patients with migraine...
  17. ncbi Selective decreased grey matter volume of the pain-matrix network in cluster headache
    Martina Absinta
    Vita Salute San Raffaele University, Italy
    Cephalalgia 32:109-15. 2012
    We assessed the pattern of regional white matter and grey matter abnormalities in patients with cluster headache (CH), using tract-based spatial statistics (TBSS) and voxel-based morphometry (VBM).
  18. ncbi Altered regional homogeneity in spontaneous cluster headache attacks: a resting-state functional magnetic resonance imaging study
    En chao Qiu
    Department of Neurology, Chinese People s Liberation Army General Hospital, Beijing, China
    Chin Med J (Engl) 125:705-9. 2012
    Functional neuroimaging study has opened an avenue for exploring the pathophysiology of cluster headache (CH)...
  19. ncbi Female cluster headache in the United States of America: what are the gender differences? Results from the United States Cluster Headache Survey
    Todd D Rozen
    Geisinger Wyoming Valley Geisinger Health System, Department of Neurology, Wilkes Barre, PA 18711, USA
    J Neurol Sci 317:17-28. 2012
    To present results from the United States Cluster Headache Survey regarding gender differences in cluster headache demographics, clinical characteristics, diagnostic delay, triggers, treatment response and personal burden.
  20. ncbi Prophylactic treatment of episodic cluster headache with intravenous bolus of methylprednisolone
    P Mir
    Department of Neurology, University Hospital Virgen del Rocio, Avda Manuel Siurot s n, 41013 Seville, Spain
    Neurol Sci 24:318-21. 2003
    ..of intravenous boluses of methylprednisolone followed by prednisone as a prophylactic treatment for episodic cluster headache. Fourteen male patients (mean age, 42...
  21. ncbi Occipital nerve stimulation for the treatment of chronic cluster headache - lessons learned from 18 months experience
    O M Mueller
    University Hospital Essen, Neurosurgery, Essen, Germany
    Cent Eur Neurosurg 72:84-9. 2011
    ..has been recognized as a valuable surgical treatment option for patients with refractory chronic cluster headache (CCH). Due to the small number of afflicted individuals, the knowledge about this specific therapy is limited...
  22. ncbi Treatment of refractory chronic cluster headache by chronic occipital nerve stimulation
    Denys Fontaine
    Centre Hospitalier Universitaire de Nice, France
    Cephalalgia 31:1101-5. 2011
    Greater occipital nerve stimulation (ONS) has been recently proposed to treat severe chronic cluster headache patients (CCH) refractory to medical treatment. We report the results of a French multidisciplinary cohort study.
  23. ncbi Long-term results of radiofrequency rhizotomy in the treatment of cluster headache
    J M Taha
    Department of Neurosurgery, University of Cincinnati College of Medicine, OH 45267-0515, USA
    Headache 35:193-6. 1995
    Although the primary treatment of chronic cluster headache is medical, surgical treatment is sometimes used...
  24. ncbi Intranasal lidocaine for cluster headache
    L Robbins
    Robbins Headache Clinic, Northbrook, Illinois, USA
    Headache 35:83-4. 1995
    Thirty male patients with cluster headache were given 4% lidocaine solution to use intranasally as an abortive therapy. Four sprays of lidocaine were used ipsilateral to the pain, and two more were used, if necessary...
  25. ncbi Preemptive oral treatment with sumatriptan during a cluster period
    I Monstad
    Nevrologisk avd, Hedmark Sentralsykehus, Elverum, Norway
    Headache 35:607-13. 1995
    ..of a 7-day period of preemptive treatment with oral sumatriptan (100 mg tid) on the frequency and severity of cluster headache attacks occurring during an established cluster headache period. Safety and tolerability were also assessed...
  26. ncbi Specific hypothalamic activation during a spontaneous cluster headache attack
    T Sprenger
    Department of Neurology, Technical University of Munich, Germany
    Neurology 62:516-7. 2004
  27. pmc Functional magnetic resonance imaging in episodic cluster headache
    Nicola Morelli
    University Centre for Adaptive Disorders and Headache UCADH, Institute of Neurology, Department of Neurosciences, University of Pisa, Pisa, Italy
    J Headache Pain 10:11-4. 2009
    We have investigated the cerebral activation centre in four patients with episodic cluster headache (CH) with functional magnetic resonance imaging (f-MRI)...
  28. ncbi Hypothalamic stimulation in chronic cluster headache: a pilot study of efficacy and mode of action
    J Schoenen
    Headache Research Unit, University Department of Neurology, CHR Citadelle, Bd du XIIème de Ligne, B 4000 Liege, Belgium
    Brain 128:940-7. 2005
    We enrolled six patients suffering from refractory chronic cluster headache in a pilot trial of neurostimulation of the ipsilateral ventroposterior hypothalamus using the stereotactic coordinates published previously...
  29. ncbi Parenteral indomethacin (the INDOTEST) in cluster headache
    F Antonaci
    Department of Neurological Sciences, Institute of Neurology IRCCS C Mondino, University of Pavia, Pavia, Italy
    Cephalalgia 23:193-6. 2003
    ..in the assessment of chronic paroxysmal hemicrania (CPH) and other unilateral headache disorders like cluster headache (CH), with which CPH can be confounded...
  30. ncbi Chronic cluster headache responsive to pramipexole
    A Palmieri
    Headache Unit, Service of Neurology, Hospital of San Donà di Piave, Italy
    Cephalalgia 26:761-2. 2006
  31. ncbi Diagnostic and therapeutic trajectory of cluster headache patients in Flanders
    E Van Alboom
    Department of Neurology of Ghent University Hospital, Ghent, Belgium
    Acta Neurol Belg 109:10-7. 2009
    A fraction of cluster headache (CH) patients face diagnostic delay, misdiagnosis, undertreatment and mismanagement. Specific data for Flanders are warranted.
  32. ncbi Cluster headache, hypothalamus, and orexin
    Philip R Holland
    Headache Research Group, Department of Neurology, University of California, San Francisco, Box 0114, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Curr Pain Headache Rep 13:147-54. 2009
    b>Cluster headache (CH) is a highly disabling condition resulting in severe, recurrent unilateral bouts of pain and accompanying autonomic symptoms...
  33. ncbi Cognitive processing in cluster headache
    Stefan Evers
    Department of Neurology, University of Munster, Albert Schweitzer Str 33, 48129 Munster, Germany
    Curr Pain Headache Rep 9:109-12. 2005
    Little is known about specific changes of cognitive processing in cluster headache. Studies on event-related potentials (ERP) suggest that stimulus evaluation is impaired in chronic cluster headache and in episodic cluster headache during ..
  34. ncbi The incidence and prevalence of cluster headache: a meta-analysis of population-based studies
    M Fischera
    Department of Neurology, University of Munster, Munster, Germany
    Cephalalgia 28:614-8. 2008
    b>Cluster headache is a trigemino-autonomic cephalgia with a low prevalence. Several population-based studies on its prevalence and incidence have been performed, but with different methodology resulting in different figures...
  35. ncbi Sphenopalatine ganglion radiofrequency ablation for the management of chronic cluster headache
    Samer Narouze
    Cleveland Clinic Foundation, Pain Management Department, Cleveland, OH 44195, USA
    Headache 49:571-7. 2009
    Chronic cluster headache patients are often resistant to pharmacological management...
  36. ncbi Facilitated temporal processing of pain and defective supraspinal control of pain in cluster headache
    Armando Perrotta
    Headache Clinic, IRCCS Mediterranean Neurological Institute Neuromed, Pozzilli, Italy
    Pain 154:1325-32. 2013
    In cluster headache (CH), pathogenesis has been emphasized the role of the posterior hypothalamus...
  37. ncbi Classification of primary headaches
    R B Lipton
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461 1926, USA
    Neurology 63:427-35. 2004
    ..The four categories of primary headaches include migraine, tension-type headache, cluster headache and other trigeminal autonomic cephalalgias, and other primary headaches...
  38. ncbi Treatment costs and indirect costs of cluster headache: A health economics analysis
    Charly Gaul
    Department of Neurology, University Duisburg Essen, Essen, Germany
    Cephalalgia 31:1664-72. 2011
    b>Cluster headache (CH) is the most frequent trigemino-autonomic cephalgia. CH can manifest as episodic (eCH) or chronic cluster headache (cCH) causing significant burden of disease and requiring attack therapy and prophylactic treatment.
  39. pmc Neuroimaging in cluster headache and other trigeminal autonomic cephalalgias
    Elisa Iacovelli
    Neurology Section, Department of Medico Surgical Sciences and Biotechnologies, Sapienza University of Rome, Viale dell Universita 30, 00185, Rome, Italy
    J Headache Pain 13:11-20. 2012
    ..The available functional neuroimaging data in cluster headache and other TACs will thus be summarized...
  40. ncbi Clinical features of unilateral headaches beyond migraine and cluster headache and their response to indomethacin
    Stefan Seidel
    Department of Neurology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 123:536-41. 2011
    The majority of previous studies on unilateral headaches beyond migraine and cluster headache have focussed on certain disorders such as paroxysmal hemicrania, SUNCT and primary stabbing headache...
  41. ncbi Melatonin as adjunctive therapy in the prophylaxis of cluster headache: a pilot study
    Tamara Pringsheim
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada
    Headache 42:787-92. 2002
    The periodicity of cluster headache suggests involvement of the suprachiasmatic nucleus of the hypothalamus, the biological clock...
  42. ncbi Central nervous system dysregulation extends beyond the pain-matrix network in cluster headache
    Maria A Rocca
    Institute of Experimental Neurology, Department of Neuroradiology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Cephalalgia 30:1383-91. 2010
    In this study, we investigated whether abnormalities of the brain resting-state networks (RSNs) occur in patients with episodic cluster headache (CH), outside the attacks of the disease.
  43. ncbi The psychiatric comorbidities of cluster headache
    Matthew S Robbins
    Montefiore Headache Center, 1575 Blondell Avenue, Suite 225, Bronx, NY 10461, USA
    Curr Pain Headache Rep 17:313. 2013
    Although the comorbidity of migraine has been extensively studied, the relationships between cluster headache and psychiatric disease have not been well-addressed...
  44. ncbi Epidemiology and genetics of cluster headache
    Michael Bjørn Russell
    Department of Neurology, Akershus University Hospital, Oslo, Norway
    Lancet Neurol 3:279-83. 2004
    b>Cluster headache, the most severe primary headache, is characterised by unilateral pain, ipsilateral autonomic features, and, in many cases, restlessness...
  45. ncbi Clinical profile of cluster headaches in Japan: low prevalence of chronic cluster headache, and uncoupling of sense and behaviour of restlessness
    Noboru Imai
    Department of Neurology, Shizuoka Red Cross Hospital, 8 2 Ohtemachi, Aoi ku, Shizuoka, Japan
    Cephalalgia 31:628-33. 2011
    ..This study examined the clinical profile of cluster headaches in Japan and the potential presence of features peculiar to Japan. Most previous studies of cluster headaches have focused on Caucasian populations...
  46. ncbi Eletriptan for the short-term prophylaxis of cluster headache
    Karin Zebenholzer
    Department of Neurology, University of Vienna Austria Medical School
    Headache 44:361-4. 2004
    A beneficial prophylactic effect from eletriptan 40 mg given to a single patient with cluster headache was observed.
  47. ncbi Case series of four different headache types presenting as tooth pain
    Aurelio A Alonso
    Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Endod 32:1110-3. 2006
    ..This case series describes four patients, one each with migraine headache, cluster headache, paroxysmal hemicrania, and hemicrania continua, all of which who presented to dentists with the chief ..
  48. ncbi Valsalva-induced cluster: a new subtype of cluster headache
    James Ko
    Department of Neurology, Jefferson Headache Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Headache 42:301-2. 2002
    ..This may be the first reported case of cluster that only occurs after a defined trigger and never spontaneously. It also may be the first cluster headache subtype that is indomethacin responsive.
  49. ncbi Occipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot study
    Delphine Magis
    Headache Research Unit, Department of Neurology, Liege University, CHR Citadelle, Liege, Belgium
    Lancet Neurol 6:314-21. 2007
    Drug-resistant chronic cluster headache (drCCH) is a devastating disorder for which various destructive procedures have been tried unsuccessfully. Occipital nerve stimulation (ONS) is a new, safe strategy for intractable headaches...
  50. ncbi Outpatient intravenous dihydroergotamine for refractory cluster headache
    E Magnoux
    Montreal Migraine Clinic, Quebec, Canada
    Headache 44:249-55. 2004
    To evaluate the efficacy and safety of outpatient intravenous dihydroergotamine (DHE) for treatment of refractory cluster headache.
  51. ncbi Sphenopalatine endoscopic ganglion block: a revision of a traditional technique for cluster headache
    Giovanni Felisati
    University of Milan, Via di Rudini 8, 20100 Milan, Italy
    Laryngoscope 116:1447-50. 2006
    The diagnosis of chronic cluster headache (CH), the most painful form of headache, is based on typical clinical features characterized by strictly unilateral pain with no side shift and ipsilateral oculofacial autonomic phenomena...
  52. ncbi Effectiveness of intranasal zolmitriptan in acute cluster headache: a randomized, placebo-controlled, double-blind crossover study
    Elizabeth Cittadini
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, England
    Arch Neurol 63:1537-42. 2006
    b>Cluster headache is a form of primary headache in which attacks are rapid in onset with very severe pain. The mainstays of acute therapy are inhaled oxygen and sumatriptan succinate injection.
  53. ncbi Cluster headache: clinical presentation, lifestyle features, and medical treatment
    Markus Schürks
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Headache 46:1246-54. 2006
    b>Cluster headache (CH) is a rare but severe headache form with a distinct clinical presentation. Misdiagnoses and mismanagement among these patients are high.
  54. ncbi Cluster headache in the Taiwanese -- a clinic-based study
    K H Lin
    Department of Internal Medicine, Chia I Veterans Hospital, Chia Yi, Taiwan
    Cephalalgia 24:631-8. 2004
    b>Cluster headache has not been fully investigated in Asians. One hundred and four patients (90M/14F; mean age 39.2 +/- 12.2 years) with cluster headache were recruited from two major headache clinics in Taiwan...
  55. ncbi Cluster headache: a review of neuroimaging findings
    Alexandre F M DaSilva
    PAIN Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Curr Pain Headache Rep 11:131-6. 2007
    Classified as a trigeminal autonomic cephalalgia, cluster headache is characterized by recurrent short-lived excruciating pain attacks, which are concurrent with autonomic signs...
  56. ncbi Divalproex sodium in the treatment of migraine and cluster headaches
    R Michael Gallagher
    University Headache Center, Moorestown, NJ 08057 1550, USA
    J Am Osteopath Assoc 102:92-4. 2002
    ..Overall, divalproex sodium was found to be an effective and generally well-tolerated prophylactic treatment option as monotherapy or in polytherapy for migraine and cluster headache.
  57. ncbi Differences in clinical characteristics and frequency of accompanying migraine features in episodic and chronic cluster headache
    C Gaul
    Department of Neurology and Headache Centre, University Duisburg Essen, Hufelandstrasse 55, 45147 Essen, Germany
    Cephalalgia 32:571-7. 2012
    Data on clinical differences between episodic (eCH) and chronic cluster headache (cCH) and accompanying migraine features are limited.
  58. ncbi Cluster headache: diagnosis and treatment
    Rashmi Halker
    Department of Neurology, Mayo Clinic Arizona, Phoenix, Arizona, USA
    Semin Neurol 30:175-85. 2010
    b>Cluster headache is a rare yet exquisitely painful primary headache disorder occurring in either episodic or chronic patterns...
  59. ncbi Possible predictive factors in the evolution of episodic to chronic cluster headache
    P Torelli
    Headache Center, Institute of Neurology, University of Parma, Italy
    Headache 40:798-808. 2000
    ..study was to identify general factors and distinctive clinical features differentiating patients with chronic cluster headache (CH) evolved from episodic CH and patients with episodic CH...
  60. ncbi Aspects on the pathophysiology of migraine and cluster headache
    L Edvinsson
    Department of Internal Medicine, Lund University Hospital, S 221 85 Lund, Sweden
    Pharmacol Toxicol 89:65-73. 2001
    ..In cluster headache and in a case of chronic paroxysmal headache there was in addition release of the parasympathetic ..
  61. ncbi [Stimulation of the occipital nerve in the treatment of drug-resistant cluster headache]
    Cristian de Quintana-Schmidt
    Servicio de Neurocirugia, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Espana
    Rev Neurol 51:19-26. 2010
    To evaluate the occipital nerve stimulation therapy in as a treatment for drug-resistant cluster headache.
  62. ncbi Peripheral neurostimulation for the treatment of refractory cluster headache, long-term follow-up: case report
    Antonios Mammis
    Department of Neurosurgery, Cushing Neuroscience Institutes, Hofstra University School of Medicine and North Shore University Hospital, Manhasset, New York, USA
    Neuromodulation 14:432-5; discussion 435. 2011
    b>Cluster headache is a headache syndrome characterized by periodic episodes of intense headache with spontaneous remission...
  63. pmc Valsalva-induced cluster headache
    Brian E McGeeney
    Department of Neurology, Boston University School of Medicine, Boston, MA, USA
    J Headache Pain 7:416-8. 2006
    A case valsalva-induced cluster headache is presented. Cluster attacks induced by valsalva manoeuvres alone were only recently described, and such patients have features of cough headache and cluster headache...
  64. ncbi Dental presentations of cluster headaches
    Sheldon G Gross
    Connecticut Center for Oral and Facial Pain, One Northwestern Drive, Bloomfield, CT 06002, USA
    Curr Pain Headache Rep 10:126-9. 2006
    b>Cluster headache has been defined by the International Headache Society (IHS) as one of the primary headaches. A primary headache is a headache that has no other known cause, such as infection or trauma...
  65. ncbi The treatment of cluster headache with repetitive intravenous dihydroergotamine
    P J Mather
    Department of Medicine, Temple University Hospital, Philadelphia, PA
    Headache 31:525-32. 1991
    We reviewed our experience with 54 cluster headache patients (23 episodic, 31 chronic) admitted to our headache center 64 tines over the past five years and treated with repetitive intravenous dihydroergotamine (IV DHE)...
  66. ncbi The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache
    Jes Olesen
    University of Copenhagen, Department of Neurology, Glostrup Hospital, Ndr Ringvej 57, DK 2600 Glostrup, Copenhagen, Denmark
    Pharmacol Ther 120:157-71. 2008
    ..e. independent disorders that are not caused by another disease) are migraine, tension-type headache and cluster headache. All primary headaches are in need of better treatments...
  67. ncbi Occipital nerve stimulation for chronic cluster headache and hemicrania continua: pain relief and persistence of autonomic features
    T J Schwedt
    Mayo Clinic College of Medicine, Scottsdale, AZ 85259, USA
    Cephalalgia 26:1025-7. 2006
  68. ncbi Burden of cluster headache
    R M Jensen
    Danish Headache Centre, Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    Cephalalgia 27:535-41. 2007
    The aim was to analyse the socioeconomic burden of cluster headache in patients from a tertiary headache centre...
  69. ncbi Treatment of intractable chronic cluster headache by occipital nerve stimulation in 14 patients
    Brian Burns
    Headache Group, Department of Neurology, University of California San Francisco, San Francisco, CA 19143 0114, USA
    Neurology 72:341-5. 2009
    b>Cluster headache is a primary headache involving repeated attacks of excruciatingly severe headache usually occurring several times a day...
  70. ncbi Cluster headache prevalence in the Italian general population
    Paola Torelli
    Headache Center, Section of Neurology, Department of Neuroscience, University of Parma, Italy
    Neurology 64:469-74. 2005
    Prevalence of cluster headache (CH) is estimated at 56 to 69 per 100,000.
  71. ncbi Altered metabolism in frontal brain circuits in cluster headache
    T Sprenger
    Department of Neurology, Klinikum rechts der Isaar, Technische Universitat Munchen, Munich, Germany
    Cephalalgia 27:1033-42. 2007
    Neuroimaging studies have explored cerebral activation patterns in patients with cluster headache (CH) during attacks and have revealed activation of multiple brain areas known to belong to the general pain-processing network...
  72. ncbi Topiramate in the prophylactic treatment of cluster headache
    Miguel J A Láinez
    Department of Neurology, Hospital Clinico Universitario, Universidad de Valencia, Avenida Blasco Ibañez 17, 46 010 Valencia, Spain
    Headache 43:784-9. 2003
    The role of topiramate in the prophylactic treatment of cluster headache is still unclear. The aim of this study was to evaluate the effectiveness of topiramate in a group of patients with refractory episodic or chronic cluster headache.
  73. ncbi Hypothalamic deep brain stimulation in positron emission tomography
    Arne May
    Department of Systems Neuroscience, University of Hamburg, D 20246 Hamburg, Germany
    J Neurosci 26:3589-93. 2006
    Recently, functional imaging data have underscored the crucial role the hypothalamus plays in cluster headache, one of the most severe forms of primary headache. This prompted the application of hypothalamic deep brain stimulation...
  74. ncbi Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene
    M Schurks
    Department of Neurology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Neurology 66:1917-9. 2006
    The G1246A polymorphism in the gene of the hypocretin receptor 2 (HCRTR2) has been linked to the risk for cluster headache (CH). The authors examined this association in a large sample of 226 patients with CH and 266 controls from Germany...
  75. ncbi High-flow oxygen for treatment of cluster headache: a randomized trial
    Anna S Cohen
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square London, England
    JAMA 302:2451-7. 2009
    b>Cluster headache is an excruciatingly painful primary headache syndrome, with attacks of unilateral pain and cranial autonomic symptoms. The current licensed treatment for acute attacks is subcutaneous sumatriptan.
  76. ncbi A negative trial of sodium valproate in cluster headache: methodological issues
    M El Amrani
    Service de Neurologie, Hopital Lariboisiere, Paris, France
    Cephalalgia 22:205-8. 2002
    ..of a double-blind placebo controlled study of sodium valproate (SV) (1000-2000 mg/day) in the prophylaxis of cluster headache CH. Episodic and chronic CH were defined according to the International Headache Society classification...
  77. pmc Chronic cluster headache: a French clinical descriptive study
    A Donnet
    Department of Neurology, Clinical Neuroscience Federation, La Timone Hospital, Marseille, France
    J Neurol Neurosurg Psychiatry 78:1354-8. 2007
    b>Cluster headache (CH) is a relatively rare disease and episodic CH is more frequent than chronic CH. Few studies have described the characteristics of patients with chronic CH.
  78. ncbi Single high-dose steroid treatment in episodic cluster headache
    F Antonaci
    Department of Neurological Sciences, IRCCS C Mondino, University of Pavia, 27100 Pavia, Italy
    Cephalalgia 25:290-5. 2005
    Corticosteroids appear to be the most rapid-acting of the prophylactic drugs used in the treatment of cluster headache (CH). These agents are frequently employed as a short-term regimen to induce clinical remission...
  79. ncbi A polymorphism of the hypocretin receptor 2 gene is associated with cluster headache
    I Rainero
    Neurology III Headache Center, Department of Neuroscience, University of Turin, Via Cherasco 15 10126 Turin, Italy
    Neurology 63:1286-8. 2004
    Several polymorphisms of the hypocretin/orexin system genes were evaluated in 109 cluster headache patients and 211 controls. The 1246 G>A polymorphism of the gene was significantly different between cases and controls...
  80. ncbi Outcome of trigeminal nerve section in the treatment of chronic cluster headache
    R G Jarrar
    Departments of Neurology, Mayo Clinic, Rochester, MN, USA
    Neurology 60:1360-2. 2003
    Chronic cluster headache accounts for 10 to 15% of all patients with cluster headache and is often resistant to medical management...
  81. ncbi Acute and preventive pharmacologic treatment of cluster headache
    George J Francis
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, T3B 6A8, Canada
    Neurology 75:463-73. 2010
    b>Cluster headache (CH) is a rare and disabling primary headache disorder. CH attacks are unilateral, short, severe headaches associated with ipsilateral autonomic symptoms that occur in a periodic fashion...
  82. ncbi Zolmitriptan nasal spray in the acute treatment of cluster headache: a meta-analysis of two studies
    Cecilia Hedlund
    Department of Statistics and Informatics AstraZeneca R and D, Sodertalje, Sweden
    Headache 49:1315-23. 2009
    To conduct an individual subject meta-analysis of available controlled studies of zolmitriptan nasal spray in the acute treatment of cluster headache.
  83. ncbi Success, failure, and putative mechanisms in hypothalamic stimulation for drug-resistant chronic cluster headache
    Massimo Leone
    Department of Neurology, Headache Centre and Pain Neuromodulation Unit, Fondazione Istituto Nazionale Neurologico Carlo Besta, Milano, Italy
    Pain 154:89-94. 2013
    Drug-resistant chronic cluster headache (CH) is an unremitting illness with excruciatingly severe headaches that occur several times daily...
  84. ncbi Cluster headache with aura
    Todd D Rozen
    Geisinger Specialty Clinic, MC 37 31, 1000 East Mountain Drive, Wilkes Barre, PA 18711, USA
    Curr Pain Headache Rep 15:98-100. 2011
    Aura was not recognized as a clinical symptom of cluster headache until fairly recently, but studies now have indicated that upwards of 20% of patients with cluster headache may have aura, the same percentage of migraine sufferers who ..
  85. ncbi Management of cluster headache
    Peer C Tfelt-Hansen
    Danish Headache Center, Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    CNS Drugs 26:571-80. 2012
    The prevalence of cluster headache is 0.1% and cluster headache is often not diagnosed or misdiagnosed as migraine or sinusitis...
  86. ncbi Treatment of cluster headache attacks with less than 6 mg subcutaneous sumatriptan
    Nora Gregor
    Department of Neurology, University of Munster, Germany
    Headache 45:1069-72. 2005
    Subcutaneous (SQ) sumatriptan 6 mg is effective in the treatment of acute cluster headache attacks. However, patients sometimes benefit from a dose less than 6 mg.
  87. ncbi Investigation into sleep disturbance of patients suffering from cluster headache
    M E Nobre
    Department of Neurology, Universidade Federal Fluminense, Niteroi, Brazil
    Cephalalgia 25:488-92. 2005
    The new discoveries relating to cluster headache (CH) encouraged the study of the relationship of the hypothalamus to respiratory physiology and its comorbidity with sleep apnoea...
  88. ncbi Clusterlike headache in a patient with a pituitary adenoma. With a review of the literature
    P Milos
    Department of Neurology, , Sweden
    Headache 36:184-8. 1996
    ..On pharmacological testing of the pupillary response to 1% and 5% phenylephrine and 2% tyramine solutions, there was no convincing evidence of persistent sympathetic dysfunction on the earlier symptomatic side...
  89. ncbi Valproate semisodium ER for migraine and cluster headache prophylaxis
    Brigitte V Lovell
    Thomas Jefferson University, Department of Neurology, 111 South 11th Street, Suite 8130 Gibbon Building, Philadelphia, PA 19107, USA
    Expert Opin Drug Metab Toxicol 6:495-504. 2010
    Migraine and cluster headache (CH) are disabling syndromes that often require prophylactic treatment. Valproate semisodium ER (VPS ER) is FDA-approved for the treatment of epilepsy, acute mania in bipolar disorder and migraine prophylaxis.
  90. ncbi Neurostimulation in chronic cluster headache
    Delphine Magis
    Curr Pain Headache Rep 12:145-53. 2008
    About 1% of all chronic cluster headache patients become intractable (iCCH; ie, they are refractory to adequate regimens of all established preventive drugs)...
  91. ncbi Age of onset in cluster headache: the clinical spectrum (three case reports)
    S Evers
    Cephalalgia 22:160-2. 2002
  92. ncbi Antihistamine responsive cluster headache in a teenaged girl
    D Neubauer
    Department of Child Neurology, University Children's Hospital, Ljubljana, Slovenia
    Headache 37:296-8. 1997
    Episodic cluster headache is a well-recognized entity usually starting in the second decade of life. Uncommonly, the first typical symptoms may present in the first decade of life, but are rarely recognized as such during childhood...
  93. ncbi Antiepileptic drugs in the management of cluster headache and trigeminal neuralgia
    T D Rozen
    Department of Neurology, Jefferson Medical College, Thomas Jefferson University Hospital, Jefferson Headache Center, Philadelphia, PA, USA
    Headache 41:S25-32. 2001
    b>Cluster headache and trigeminal neuralgia are relatively rare but debilitating neurologic conditions...
  94. ncbi Intranasal medications for the treatment of migraine and cluster headache
    Alan M Rapoport
    Columbia University College of Physicians and Surgeons, New York, NY, USA
    CNS Drugs 18:671-85. 2004
    ..and one experimental medication (civamide, a cis-isomer of capsaicin) for the treatment of migraine and cluster headache. Although the efficacy of intranasal agents varies with the product used, intranasal delivery may be both ..
  95. ncbi Age at onset and sex ratio in cluster headache: observations over three decades
    K Ekbom
    Department of Neurology at the Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden
    Cephalalgia 22:94-100. 2002
    Five hundred and fifty-four patients with episodic cluster headache (ECH) and chronic cluster headache (CCH) were examined between 1963 and 1997...
  96. ncbi Behavior during cluster headache
    Paola Torelli
    Headache Center, Section of Neurology, Department of Neuroscience, University of Parma, Via Gramsci, 14, 43100 Parma, Italy
    Curr Pain Headache Rep 9:113-9. 2005
    b>Cluster headache (CH), also known as "suicide headache," is characterized by a distinctive behavior during attacks. In 80% to 90% of cases, patients are restless and constantly moving in a vain attempt to relieve pain...
  97. ncbi Verapamil for cluster headache. Clinical pharmacology and possible mode of action
    Peer Tfelt-Hansen
    Danish Headache Centre, Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    Headache 49:117-25. 2009
    ..High-dose verapamil (360-720 mg) is, however, currently the mainstay in the prophylactic treatment of cluster headache. The oral pharmacokinetics are variable...
  98. ncbi Cluster headache: evidence for a disorder of circadian rhythm and hypothalamic function
    Tamara Pringsheim
    Department of Neurology, University of Toronto, ON, Canada
    Can J Neurol Sci 29:33-40. 2002
    ..This article reviews the literature for evidence of a disorder of circadian rhythm and hypothalamic function in cluster headache. Cluster headache exhibits diurnal and seasonal rhythmicity...
  99. ncbi Interictal pain in cluster headache
    Michael J Marmura
    Thomas Jefferson University, Philadelphia, PA, USA
    Cephalalgia 30:1531-4. 2010
    b>Cluster headache is characterized by severe attacks of unilateral pain, but many patients experience symptoms more commonly associated with migraine such as persistent pain.
  100. ncbi Connectivity of an effective hypothalamic surgical target for cluster headache
    S L F Owen
    University Laboratory of Physiology, University of Oxford, Oxford, UK
    J Clin Neurosci 14:955-60. 2007
    ..In a patient with chronic cluster headache we implanted a deep brain stimulating electrode into the ipsilateral postero-medial hypothalamus to ..
  101. pmc Prevalence of patent foramen ovale in a large series of patients with migraine with aura, migraine without aura and cluster headache, and relationship with clinical phenotype
    Giorgio Dalla Volta
    Neurologia, Istituto Clinico Città di Brescia, Brescia, Italy
    J Headache Pain 6:328-30. 2005
    ..patients with migraine with aura (MA+), 74 patients with migraine without aura (MA-), and 38 patients with cluster headache (CH). One-hundred-sixty-one MA+subjects (61.9%), 12 MA-subjects (16.2%), and 14 CH-subjects (36...

Research Grants7

  1. PALLIDAL PHYSIOLOGY IN HUMAN AND PRIMATE DYSTONIA
    PHILIP STARR; Fiscal Year: 2005
    ..Development of an animal model in a large nonhuman primate will open the possibility for further detailed investigations of basal ganglia physiology in dystonia, beyond those which are possible during human surgery. ..
  2. Hypothalamic Deep Brain Stimulation for Morbid Obesity:Development of a Pig Model
    William P Melega; Fiscal Year: 2010
    ..g., Parkinson's disease, epilepsy, cluster headache)...
  3. MODULATORY ROLE OF GABA AND 5HT RECEPTORS IN MIGRAINE
    F Cutrer; Fiscal Year: 1999
    Despite the fact that vascular head pain including migraine and cluster headache afflicts up to 15% of the population and inflicts significant suffering and economic loss, its pathophysiology and mechanism of treatment remain obscure...
  4. SEROTONIN 1B AND 1D RECEPTORS IN HEAD PAIN
    Sonja Potrebic; Fiscal Year: 2003
    ..A clinical study will test the proposed selectivity of 5HT1B/1D agonists for migraine and cluster headache.
  5. DBS Effects on Mood and Cognition in Parkinsons Disease
    Michael Okun; Fiscal Year: 2007
    ..This proposal includes active and experienced mentoring, access to diverse resources, and a scientific environment suited specifically for the development of the PI as an independent physician scientist. ..
  6. Outcome Measures in Idiopathic Intracranial Hypertension
    Deborah Friedman; Fiscal Year: 2008
    ..Acquire the training, mentoring and experience necessary to conduct independent, funded clinical research in ophthalmologic and neurological disorders Obtain a Masters Degree in Public Health/Clinical Investigator track ..
  7. Automated Cognitive Assessment System
    Norman Gordon; Fiscal Year: 2004
    ..abstract_text> ..