status epilepticus

Summary

Summary: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)

Top Publications

  1. ncbi Nonconvulsive status epilepticus: Epilepsy Research Foundation workshop reports
    Matthew Walker
    Epilepsy Research Foundation, London, United Kingdom
    Epileptic Disord 7:253-96. 2005
  2. doi Expression profile of microRNAs in rat hippocampus following lithium-pilocarpine-induced status epilepticus
    Kai Hu
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China
    Neurosci Lett 488:252-7. 2011
  3. ncbi Kindling and status epilepticus models of epilepsy: rewiring the brain
    Kiyoshi Morimoto
    Department of Neuropsychiatry, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Prog Neurobiol 73:1-60. 2004
  4. pmc The pilocarpine model of temporal lobe epilepsy
    Giulia Curia
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery and Physiology, McGill University, Montreal, QC, Canada
    J Neurosci Methods 172:143-57. 2008
  5. pmc Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects
    Eva M Jimenez-Mateos
    Department of Physiology and Medical Physics and Centre for Study of Neurological Disorders, Royal College of Surgeons in Ireland, Dublin, Ireland
    Nat Med 18:1087-94. 2012
  6. doi Pilocarpine vs. lithium-pilocarpine for induction of status epilepticus in mice: development of spontaneous seizures, behavioral alterations and neuronal damage
    Christine J Müller
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Eur J Pharmacol 619:15-24. 2009
  7. doi Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice
    Christine J Müller
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Bunteweg 17, D 30559 Hannover, Germany
    Exp Neurol 219:284-97. 2009
  8. doi Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice
    Tobias Engel
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    FASEB J 26:1616-28. 2012
  9. ncbi Long-term neuronal replacement in adult rat hippocampus after status epilepticus despite chronic inflammation
    Sara Bonde
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84, Lund, Sweden
    Eur J Neurosci 23:965-74. 2006
  10. doi Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling
    Elena Avignone
    INSERM U603, Universite Paris Descartes, Unité Mixte de Recherche S603, Centre National de la Recherche Scientifique UMR 8154, 75006 Paris, France
    J Neurosci 28:9133-44. 2008

Research Grants

  1. Genomics of Pediatric Headache Disorders
    Andrew Hershey; Fiscal Year: 2006
  2. Intranasal CNS delivery of drugs against organophosphorous threat agents
    ARYAN MANGALAM NAMBOODIRI; Fiscal Year: 2013
  3. Prostaglandin signaling following seizures
    Jianxiong Jiang; Fiscal Year: 2013
  4. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2010
  5. Neuroprotective strategies in seizure-induced damage
    JANA VELISKOVA; Fiscal Year: 2011
  6. Subunit dependent properties of kainate receptors
    David D Mott; Fiscal Year: 2013
  7. Epigenetic modulation of epileptogenesis.
    PEYMAN GOLSHANI; Fiscal Year: 2010
  8. Novel Treatment Strategies for Targeting Posttraumatic Epilepsy
    Helen M Bramlett; Fiscal Year: 2013
  9. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2013
  10. Astrocyte Function and Temporal Lobe Epilepsy
    JAY ROBERT VARGAS; Fiscal Year: 2010

Detail Information

Publications442 found, 100 shown here

  1. ncbi Nonconvulsive status epilepticus: Epilepsy Research Foundation workshop reports
    Matthew Walker
    Epilepsy Research Foundation, London, United Kingdom
    Epileptic Disord 7:253-96. 2005
    In April 2004, a group of physicians with an interest in nonconvulsive status epilepticus representing a spectrum of opinion met in Oxford, sponsored by the Epilepsy Research Foundation (a charitable organization), to discuss and debate ..
  2. doi Expression profile of microRNAs in rat hippocampus following lithium-pilocarpine-induced status epilepticus
    Kai Hu
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China
    Neurosci Lett 488:252-7. 2011
    ..Here we investigated microRNA expression pattern in post status epilepticus rats (24h after status)...
  3. ncbi Kindling and status epilepticus models of epilepsy: rewiring the brain
    Kiyoshi Morimoto
    Department of Neuropsychiatry, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Prog Neurobiol 73:1-60. 2004
    ..From recent studies on the kindling and status epilepticus models, which have been used most extensively to investigate temporal lobe epilepsy, it is now clear that ..
  4. pmc The pilocarpine model of temporal lobe epilepsy
    Giulia Curia
    Montreal Neurological Institute and Departments of Neurology and Neurosurgery and Physiology, McGill University, Montreal, QC, Canada
    J Neurosci Methods 172:143-57. 2008
    Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the use of models of status epilepticus (SE), as in the case of the pilocarpine model...
  5. pmc Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects
    Eva M Jimenez-Mateos
    Department of Physiology and Medical Physics and Centre for Study of Neurological Disorders, Royal College of Surgeons in Ireland, Dublin, Ireland
    Nat Med 18:1087-94. 2012
    ..In experimental models of prolonged, injurious seizures (status epilepticus) and in human epilepsy, we found upregulation of miR-134, a brain-specific, activity-regulated miRNA that ..
  6. doi Pilocarpine vs. lithium-pilocarpine for induction of status epilepticus in mice: development of spontaneous seizures, behavioral alterations and neuronal damage
    Christine J Müller
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Eur J Pharmacol 619:15-24. 2009
    ..In this model, the cholinomimetic convulsant pilocarpine is used to induce a status epilepticus, which is followed by hippocampal damage and development of spontaneous recurrent seizures...
  7. doi Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice
    Christine J Müller
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Bunteweg 17, D 30559 Hannover, Germany
    Exp Neurol 219:284-97. 2009
    ..and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in the C57BL/6 (B6) inbred strain of mice, which is commonly used as background strain for genetically ..
  8. doi Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice
    Tobias Engel
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    FASEB J 26:1616-28. 2012
    Prolonged seizures [status epilepticus (SE)] constitute a neurological emergency that can permanently damage the brain...
  9. ncbi Long-term neuronal replacement in adult rat hippocampus after status epilepticus despite chronic inflammation
    Sara Bonde
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84, Lund, Sweden
    Eur J Neurosci 23:965-74. 2006
    Dentate gyrus (DG) neurogenesis is transiently increased during the first weeks after status epilepticus (SE)...
  10. doi Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling
    Elena Avignone
    INSERM U603, Universite Paris Descartes, Unité Mixte de Recherche S603, Centre National de la Recherche Scientifique UMR 8154, 75006 Paris, France
    J Neurosci 28:9133-44. 2008
    ..Here, we used a model of status epilepticus (SE) induced by intraperitoneal kainate injections to characterize the properties of microglial cells in ..
  11. pmc Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus
    G E Serrano
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 31:14850-60. 2011
    ..and a multifunctional neuronal modulator, is rapidly induced in select populations of cortical neurons after status epilepticus. The consequences of rapid activity-triggered induction of COX-2 in neurons have been the subject of much ..
  12. pmc Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus
    Ren Zhi Zhan
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurophysiol 102:670-81. 2009
    ..from both normotopic and hilar ectopic granule cells in slices from rats subjected to pilocarpine-induced status epilepticus. After status epilepticus, tonic GABA current was an order of magnitude greater than control in normotopic ..
  13. ncbi Status epilepticus severity influences the long-term outcome of neurogenesis in the adult dentate gyrus
    Paul Mohapel
    Section of Restorative Neurology, Wallenberg Neuroscience Center, SE 221 84 Lund, Sweden
    Neurobiol Dis 15:196-205. 2004
    b>Status epilepticus (SE) is characterized by continual seizure activity that can vary widely in the intensity of convulsions...
  14. ncbi Upregulation of nitric oxide synthase II contributes to apoptotic cell death in the hippocampal CA3 subfield via a cytochrome c/caspase-3 signaling cascade following induction of experimental temporal lobe status epilepticus in the rat
    Y C Chuang
    Department of Neurology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan, ROC
    Neuropharmacology 52:1263-73. 2007
    b>Status epilepticus results in preferential neuronal cell loss in the hippocampus...
  15. ncbi Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy
    E A van Vliet
    Epilepsy Institute of the Netherlands SEIN, Heemstede
    Brain 130:521-34. 2007
    ..Albumin extravasation in human was prominent after status epilepticus (SE) in astrocytes and neurons, and also in hippocampus of TLE patients...
  16. pmc Enhanced astrocytic Ca2+ signals contribute to neuronal excitotoxicity after status epilepticus
    Shinghua Ding
    Silvio Conte Center for Integration at the Tripartite Synapse, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:10674-84. 2007
    b>Status epilepticus (SE), an unremitting seizure, is known to cause a variety of traumatic responses including delayed neuronal death and later cognitive decline...
  17. ncbi Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesis
    H E Scharfman
    Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, West Haverstraw, New York 10993 1195, USA
    J Neurosci 20:6144-58. 2000
    ..granule cells was found at the hilar/CA3 border several weeks after pilocarpine- or kainic acid-induced status epilepticus. Intracellular recordings from pilocarpine-treated rats showed that these "granule-like" neurons were ..
  18. ncbi Trafficking of GABA(A) receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus
    David E Naylor
    Department of Neurology, Veterans Administration Greater Los Angeles Healthcare System, University of California, Los Angeles, California 90073, USA
    J Neurosci 25:7724-33. 2005
    During status epilepticus (SE), GABAergic mechanisms fail and seizures become self-sustaining and pharmacoresistant...
  19. ncbi The pilocarpine model of epilepsy: what have we learned?
    Fulvio A Scorza
    Disciplina de Neurologia Experimental, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Rua Botucatu, 862, Edifício José Leal Prado, 04023 900 São Paulo, SP, Brasil
    An Acad Bras Cienc 81:345-65. 2009
    ..that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies ..
  20. ncbi Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy
    Wolfgang Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Bunteweg 17, Hannover, Germany
    Epilepsy Res 50:105-23. 2002
    ..of temporal lobe epilepsy (TLE), post-status models of TLE in which epilepsy develops after a sustained status epilepticus, and genetic models of different types of epilepsy...
  21. ncbi Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus
    M G De Simoni
    Laboratory of Inflammation and Nervous System Diseases and Laboratory of Experimental Neurology, Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Eur J Neurosci 12:2623-33. 2000
    Limbic status epilepticus was induced in rats by unilateral 60-min electrical stimulation of the CA3 region of the ventral hippocampus...
  22. pmc Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus
    T Engel
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Cell Death Dis 1:e79. 2010
    ..Here, we investigated the development of epilepsy triggered by status epilepticus in wild-type and p53-deficient mice...
  23. pmc Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma
    Tobias Engel
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    FASEB J 24:853-61. 2010
    ..In the present study, we report that status epilepticus (SE) triggered by intra-amygdala kainic acid in mice causes rapid p53 accumulation and subsequent ..
  24. doi Involvement of P2X4 receptors in hippocampal microglial activation after status epilepticus
    Lauriane Ulmann
    Institut de Genomique Fonctionnelle, LabEx ICST, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5203, Universite Montpellier, Montpellier, France
    Glia 61:1306-19. 2013
    ..investigated the potential involvement of P2X4R in microglial functions in a model of kainate (KA)-induced status epilepticus (SE)...
  25. doi Oxidative stress mediates hippocampal neuron death in rats after lithium-pilocarpine-induced status epilepticus
    Jinzhi Liu
    Department of Neurology, Qianfoshan Hospital, Medical School of Shandong University, No 66, Jingshi Road, Jinan, Shandong 250014, PR China
    Seizure 19:165-72. 2010
    ..as the over-production of free radicals, can dramatically alter neuronal function and has been linked to status epilepticus (SE)...
  26. ncbi Treatment with valproate after status epilepticus: effect on neuronal damage, epileptogenesis, and behavioral alterations in rats
    Claudia Brandt
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Neuropharmacology 51:789-804. 2006
    ..seizures, can be initiated by a number of brain damaging insults, including traumatic brain injury, status epilepticus (SE), and stroke. Such acquired epilepsy is often associated with memory impairment and behavioral problems...
  27. pmc Experimental models of status epilepticus and neuronal injury for evaluation of therapeutic interventions
    Doodipala Samba Reddy
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M University Health Science Center, 8447 State Highway 47, MREB Building, Bryan, TX 77807, USA
    Int J Mol Sci 14:18284-318. 2013
    This article describes current experimental models of status epilepticus (SE) and neuronal injury for use in the screening of new therapeutic agents...
  28. pmc Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, Stanford, California 94305, USA
    J Neurosci 29:8259-69. 2009
    ..the dorsal hippocampus for prolonged periods beginning within hours after rats sustained pilocarpine-induced status epilepticus. Infusion for 1 month reduced aberrant Timm staining (a marker of mossy fibers) in the granule cell layer ..
  29. doi Up-regulation of endothelial endothelin-1 expression prior to vasogenic edema formation in the rat piriform cortex following status epilepticus
    Seung Mook Jo
    Department of Emergency Medical Services, Eulji University, Seongnam, Gyeonggi do 461 713, South Korea
    Neurosci Lett 501:25-30. 2011
    ..correlation between endogenous ET-1 expression and vasogenic edema formation in the pirifom cortex following status epilepticus (SE)...
  30. ncbi Status epilepticus evokes prolonged increase in the expression of CCL3 and CCL4 mRNA and protein in the rat brain
    Anna Guzik-Kornacka
    The Nencki Institute of Experimental Biology, Warsaw, Poland
    Acta Neurobiol Exp (Wars) 71:193-207. 2011
    ..in the enthorinal and piriform cortices, amygdala, and hippocampus showing the largest increase at 4D after status epilepticus. Increase in mRNA and protein levels of CCL3 and CCL4 in the animal model of temporal lobe epilepsy suggests ..
  31. ncbi Magnetic resonance imaging of changes elicited by status epilepticus in the rat brain: diffusion-weighted and T2-weighted images, regional blood volume maps, and direct correlation with tissue and cell damage
    P F Fabene
    Section of Anatomy and Histology, Department of Morphological and Biomedical Sciences, Faculty of Medicine, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
    Neuroimage 18:375-89. 2003
    ..with structural and functional magnetic resonance imaging (MRI) 12 h after the arrest of pilocarpine-induced status epilepticus lasting 4 h...
  32. pmc Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: role of NMDA receptor activation and NMDA dependent calcium entry
    Laxmikant S Deshpande
    Department of Neurology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Eur J Pharmacol 583:73-83. 2008
    ..cell death using low magnesium (Mg2+) induced continuous high frequency epileptiform discharges (in vitro status epilepticus) in hippocampal neuronal cultures...
  33. doi Acute encephalopathy with inflammation-mediated status epilepticus
    Rima Nabbout
    Neuropaediatrics Department, Necker Hospital, APHP, Paris, INSERM U663, Paris, and Faculty of Medicine, Descartes University, Paris, France
    Lancet Neurol 10:99-108. 2011
    ..FIRES begins in school age with status epilepticus lasting several weeks, involves perisylvian areas including mesial temporal structures, and is followed by ..
  34. ncbi Treatment of refractory status epilepticus with pentobarbital, propofol, or midazolam: a systematic review
    Jan Claassen
    Department of Neurology, Division of Critical Care Neurology, and The Comprehensive Epilepsy Center, Neurological Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Epilepsia 43:146-53. 2002
    ..infusion antiepileptic drugs (cIV-AEDs) offer alternatives to pentobarbital for the treatment of refractory status epilepticus (RSE). However, no prospective randomized studies have evaluated the treatment of RSE...
  35. pmc Degeneration and proliferation of astrocytes in the mouse dentate gyrus after pilocarpine-induced status epilepticus
    Karin Borges
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    Exp Neurol 201:416-27. 2006
    ..Here, we report transient region-specific loss of astrocytes in mice early after pilocarpine-induced status epilepticus (SE)...
  36. ncbi Memory impairment following status epilepticus in immature rats: time-course and environmental effects
    Annemarieke Rutten
    Department of Neurology, Harvard Medical School, Children s Hospital, Boston, MA 02115, USA
    Eur J Neurosci 16:501-13. 2002
    b>Status epilepticus (SE) has a high mortality and morbidity rate in children. Disturbances in learning and memory are frequently associated with SE although it is not clear when the cognitive deficits occur...
  37. ncbi Impaired activation of CA3 pyramidal neurons in the epileptic hippocampus
    Giuseppe Biagini
    Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, 41100 Modena, Italy
    Neuromolecular Med 7:325-42. 2005
    ..of hippocampal-entorhinal cortex (EC) slices obtained from epileptic rats 3 wk after pilocarpine-induced status epilepticus (SE) revealed hyperexcitability in many limbic areas, but not in CA3 and medial EC layer III...
  38. doi Differential DNA methylation patterns define status epilepticus and epileptic tolerance
    Suzanne F C Miller-Delaney
    Departments of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    J Neurosci 32:1577-88. 2012
    Prolonged seizures (status epilepticus) produce pathophysiological changes in the hippocampus that are associated with large-scale, wide-ranging changes in gene expression...
  39. pmc Acute and chronic responses to the convulsant pilocarpine in DBA/2J and A/J mice
    M R Winawer
    Department of Neurology and G H Sergievsky Center, Columbia University, New York, NY 10032, USA
    Neuroscience 149:465-75. 2007
    ..These strains were compared using the chemoconvulsant pilocarpine, because pilocarpine induces status epilepticus, a state of severe, prolonged seizures...
  40. doi Increased perivascular laminin predicts damage to astrocytes in CA3 and piriform cortex following chemoconvulsive treatments
    F Gualtieri
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy
    Neuroscience 218:278-94. 2012
    b>Status epilepticus (SE) induced by pilocarpine or kainate is associated with yet not systemically investigated astrocytic and vascular injuries...
  41. ncbi Temporal patterns of the cerebral inflammatory response in the rat lithium-pilocarpine model of temporal lobe epilepsy
    Brigitte Voutsinos-Porche
    INSERM U405, Faculty of Medicine, Strasbourg, France
    Neurobiol Dis 17:385-402. 2004
    ..expression of IL1-beta, NF-kappaB, and COX-2 started by 12 h post-injection, persisted for 24 h (status epilepticus period), and returned to basal levels by 3 and 6 days (latent period)...
  42. pmc Alteration in P-glycoprotein functionality affects intrabrain distribution of quinidine more than brain entry-a study in rats subjected to status epilepticus by kainate
    Stina Syvänen
    Division of Pharmacology, LACDR, Leiden University, The Netherlands
    AAPS J 14:87-96. 2012
    ..quinidine microdialysis to study potential changes in brain P-glycoprotein functionality after induction of status epilepticus (SE) by kainate. Rats were infused with 10 or 20 mg/kg quinidine over 30 min or 4 h...
  43. doi Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus
    Giuseppe Biagini
    Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, Modena, Italy
    J Neuropathol Exp Neurol 67:687-701. 2008
    ..Here, we describe a lesion that destroys the perforant path in CA3 after status epilepticus (SE) induced by pilocarpine injection in 8-week-old rats...
  44. pmc Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine
    Andrey Mazarati
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1752, USA
    Brain 131:2071-83. 2008
    ..Male Wistar rats were subjected to LiCl and pilocarpine status epilepticus (SE)...
  45. pmc EEG spike activity precedes epilepsy after kainate-induced status epilepticus
    Andrew White
    Department of Pediatrics and Neurology, School of Medicine, University of Colorado Health Sciences Campus, Denver, Colorado 80262, USA
    Epilepsia 51:371-83. 2010
    ....
  46. doi Epileptic tolerance is associated with enduring neuroprotection and uncoupling of the relationship between CA3 damage, neuropeptide Y rearrangement and spontaneous seizures following intra-amygdala kainic acid-induced status epilepticus in mice
    E M Jimenez-Mateos
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    Neuroscience 171:556-65. 2010
    ..neuropeptide Y rearrangement and spontaneous seizures in sham- and seizure-preconditioned mice after status epilepticus induced by intra-amygdala kainate...
  47. ncbi Effects of early seizures on later behavior and epileptogenicity
    Gregory L Holmes
    Neuroscience Center at Dartmouth, Section of Neurology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Ment Retard Dev Disabil Res Rev 10:101-5. 2004
    ..These changes occur in the absence of cell loss. Although impaired cognitive function and brain changes have been well-documented following early-onset seizures, the mechanisms of seizure-induced dysfunction remain unclear...
  48. ncbi High-frequency oscillations after status epilepticus: epileptogenesis and seizure genesis
    Anatol Bragin
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Epilepsia 45:1017-23. 2004
    To investigate the temporal relation between high-frequency oscillations (HFOs) in the dentate gyrus and recurrent spontaneous seizures after intrahippocampal kainite-induced status epilepticus.
  49. pmc Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus
    J N Nicoletti
    City University of New York, New York, NY 10016, USA
    Neuroscience 151:232-41. 2008
    ..of mRNA and protein, we investigated whether VEGF protein expression increased after pilocarpine-induced status epilepticus. In addition, we administered exogenous VEGF in one experiment and blocked endogenous VEGF in another to ..
  50. pmc (R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus
    Stina Syvänen
    Division of Pharmacology, LACDR, Leiden University, P, O, Box 9502, 2300 RA Leiden, The Netherlands
    BMC Med Imaging 11:1. 2011
    ..In the rat, pharmacoresistant epilepsy can be mimicked by inducing status epilepticus by intraperitoneal injection of kainate, which leads to development of spontaneous seizures after 3 weeks to ..
  51. pmc P2X7 receptor regulates leukocyte infiltrations in rat frontoparietal cortex following status epilepticus
    Ji Eun Kim
    Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chunchon 200 702, South Korea
    J Neuroinflammation 7:65. 2010
    ..In the present study, we investigated the roles of P2X7 receptor in recruitment and infiltration of neutrophil during epileptogenesis in rat epilepsy models...
  52. ncbi Nonconvulsive seizures in the pediatric intensive care unit: etiology, EEG, and brain imaging findings
    Montri Saengpattrachai
    Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Epilepsia 47:1510-8. 2006
    ....
  53. pmc Subunit-specific trafficking of GABA(A) receptors during status epilepticus
    Howard P Goodkin
    Department of Neurology, Health Sciences Center, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 28:2527-38. 2008
    ..proposed that a reduced surface expression of GABA(A) receptors (GABARs) contributes to the pathogenesis of status epilepticus (SE), a condition characterized by prolonged seizures...
  54. pmc MicroRNA expression profile of the hippocampus in a rat model of temporal lobe epilepsy and miR-34a-targeted neuroprotection against hippocampal neurone cell apoptosis post-status epilepticus
    Kai Hu
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China
    BMC Neurosci 13:115. 2012
    ..Profiling miRNA expression in the rat model of temporal lobe epilepsy and investigating the function of specific miRNAs in epilepsy offers the prospect of a deeper understanding of the mechanisms of epilepsy...
  55. doi Transcriptional upregulation of nitric oxide synthase II by nuclear factor-kappaB promotes apoptotic neuronal cell death in the hippocampus following experimental status epilepticus
    Yao Chung Chuang
    Department of Neurology, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung County, Taiwan, Republic of China
    J Neurosci Res 88:1898-907. 2010
    Whereas status epilepticus, or the condition of continuous epileptic seizures, produces a characteristic pattern of preferential neuronal cell loss in the hippocampus, the underlying mechanism is still unsettled...
  56. pmc Regulation of cell death and epileptogenesis by the mammalian target of rapamycin (mTOR): a double-edged sword?
    Ling Hui Zeng
    Department of Pharmacy, Zhejiang University City College, Hangzhou, Zhejiang, China
    Cell Cycle 9:2281-5. 2010
    ..In particular, kainate-induced status epilepticus causes abnormal activation of the mTOR pathway, and the mTOR inhibitor, rapamycin, can decrease the ..
  57. ncbi Pilocarpine-induced seizures cause selective time-dependent changes to adult-generated hippocampal dentate granule cells
    Cynthia Walter
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Neurosci 27:7541-52. 2007
    ..Pathological brain states therefore may pose a significant hurdle for the appropriate integration of newly born endogenous, and exogenous, neurons...
  58. pmc Optimal neuroprotection by erythropoietin requires elevated expression of its receptor in neurons
    Pascal E Sanchez
    University of Lyon, F 69003 Lyon, France
    Proc Natl Acad Sci U S A 106:9848-53. 2009
    ..conditions, and they are highly sensitive to excitotoxic damage, such as occurs with pilocarpine-induced status epilepticus (Pilo-SE)...
  59. ncbi Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability
    Katherine Jakubs
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    Neuron 52:1047-59. 2006
    ..Rats were exposed to a physiological stimulus, i.e., running, or a brain insult, i.e., status epilepticus, which gave rise to neuronal death, inflammation, and chronic seizures...
  60. ncbi Reelin regulates neuronal progenitor migration in intact and epileptic hippocampus
    Chao Gong
    Department of Neurology and Program for Neuroscience, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Neurosci 27:1803-11. 2007
    ..Loss of Reelin expression in the epileptic adult hippocampus, moreover, likely contributes to ectopic chain migration and aberrant integration of newborn DGCs...
  61. ncbi "Dormant basket cell" hypothesis revisited: relative vulnerabilities of dentate gyrus mossy cells and inhibitory interneurons after hippocampal status epilepticus in the rat
    Robert S Sloviter
    Departments of Pharmacology and Neurology, University of Arizona, Tucson, Arizona 85724, USA
    J Comp Neurol 459:44-76. 2003
    ..Conversely, kainic acid-induced status epilepticus in chronically implanted animals produced similarly extensive hilar cell loss and immediate granule cell ..
  62. pmc Development of spontaneous recurrent seizures after kainate-induced status epilepticus
    Philip A Williams
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurosci 29:2103-12. 2009
    ..convulsive and nonconvulsive) was analyzed quantitatively for approximately 100 d after kainate-induced status epilepticus in adult rats...
  63. doi Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy
    Claudia Brandt
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, D 30559 Hannover, Germany
    J Neurosci 30:8602-12. 2010
    ..A variety of brain insults, including status epilepticus (SE), lead to changes in the expression of the cation-chloride cotransporters KCC2 and NKCC1, resulting in ..
  64. pmc The CREB/CRE transcriptional pathway: protection against oxidative stress-mediated neuronal cell death
    Boyoung Lee
    Department of Neuroscience, Ohio State University, Columbus, 43210, USA
    J Neurochem 108:1251-65. 2009
    ..Together, these data both extend our understanding of CREB functionality and provide in vivo validation for a model in which CREB functions as a pivotal upstream integrator of neuroprotective signaling against ROS-mediated cell death...
  65. pmc Trafficking of NMDA receptors during status epilepticus: therapeutic implications
    Claude G Wasterlain
    Department of Neurology, Veterans Administration Greater Los Angeles Healthcare System West Los Angeles, 11301 Wilshire Boulevard, West Los Angeles, CA 90073, U S A
    Epilepsia 54:78-80. 2013
    We used two models of status epilepticus (SE) to study trafficking of N-methyl-d-aspartate (NMDA) receptors...
  66. doi N (w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses
    Edward Beamer
    Institute of Ageing and Chronic Disease, Faculty of Health and Life Sciences, University of Liverpool, 4th floor Room 4 306, UCD Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    Eur J Neurosci 36:3194-203. 2012
    ..nitric oxide synthase (nNOS) inhibitor, N (w) -propyl-l-arginine (L-NPA), on kainic acid (KA)-induced status epilepticus (SE) and early epileptogenesis in C57BL/6J mice. SE was induced with 20 mg/kg KA (i.p...
  67. ncbi Effects of the vitamin E in catalase activities in hippocampus after status epilepticus induced by pilocarpine in Wistar rats
    D O Barros
    Curso de Farmácia, Faculdade Católica Rainha do Sertão, Rua Juvěncio Alves, 660, Centro, Quixada, 63900 00, CE, Brazil
    Neurosci Lett 416:227-30. 2007
    ..Neurochemical studies have proposed a role for catalase in brain mechanisms responsible by development to status epilepticus (SE) induced by pilocarpine...
  68. doi Mortality and recovery from refractory status epilepticus in the intensive care unit: a 7-year observational study
    Raoul Sutter
    Department of Neurology, Clinic for Intensive Care Medicine, University Hospital Basel, Basel, Switzerland
    Epilepsia 54:502-11. 2013
    Refractory status epilepticus (RSE) is a life-threatening neurologic emergency with high mortality and morbidity...
  69. doi Causes of status epilepticus
    Eugen Trinka
    Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University Salzburg, Salzburg, Austria
    Epilepsia 53:127-38. 2012
    b>Status epilepticus (SE) is the most extreme form of epilepsy. It describes a prolonged seizure that may occur in patients with previous epilepsy or in acute disorders of the central nervous system...
  70. pmc Reduction in delayed mortality and subtle improvement in retrograde memory performance in pilocarpine-treated mice with conditional neuronal deletion of cyclooxygenase-2 gene
    Jamie R Levin
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, USA
    Epilepsia 53:1411-20. 2012
    Pilocarpine induces prolonged status epilepticus (SE) in rodents that results in neurodegeneration and cognitive deficits, both commonly observed to be associated with human temporal lobe epilepsy...
  71. ncbi Deep brain stimulation of the anterior nucleus of the thalamus: effects of electrical stimulation on pilocarpine-induced seizures and status epilepticus
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital and University Health Network, University of Toronto, Toronto, Ontario, Canada
    Epilepsy Res 78:117-23. 2008
    ..As the optimal stimulation settings remain elusive, we studied the effects of different stimulation parameters against pilocarpine induced seizures and status epilepticus (SE).
  72. doi Status epilepticus induces long lasting increase in S100A6 expression in astrocytes
    Ewelina Jurewicz
    Nencki Institute of Experimental Biology, 3 Pasteur Street, 02 093, Warsaw, Poland
    Neurochem Res 38:1941-8. 2013
    ..we examined expression and localization of the S100A6 protein in rat brain in a model of epilepsy induced by Status Epilepticus evoked by amygdala stimulation...
  73. pmc Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation
    Jianxiong Jiang
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 110:3591-6. 2013
    ..We found that in the mouse pilocarpine model of status epilepticus (SE), systemic administration of TG6-10-1 completely recapitulates the effects of conditional ablation of ..
  74. pmc Morpho-physiologic characteristics of dorsal subicular network in mice after pilocarpine-induced status epilepticus
    De Fu He
    Epilepsy Research Lab, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore, Singapore
    Brain Pathol 20:80-95. 2010
    ..calbindin, parvalbumin (PV) and immunopositive interneurons, was found at 2 months after pilocarpine-induced status epilepticus (SE)...
  75. doi Prognostic value of electrographic postanoxic status epilepticus in comatose cardiac-arrest survivors in the therapeutic hypothermia era
    Stephane Legriel
    Intensive Care Department, CH Versailles Site André Mignot, Le Chesnay 78, France
    Resuscitation 84:343-50. 2013
    The independent prognostic significance of postanoxic status epilepticus (PSE) has not been evaluated prospectively since the introduction of therapeutic hypothermia...
  76. doi Mossy fiber sprouting in pilocarpine-induced status epilepticus rat hippocampus: a correlative study of diffusion spectrum imaging and histology
    Li Wei Kuo
    Interdisciplinary MRI MRS Lab, Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan
    Neuroimage 41:789-800. 2008
    ..study between diffusion characteristics and the severity of MFS was investigated in the pilocarpine-induced status epilepticus (SE) rat model. Nine SE rats and five control rats were studied with MRI and histological Timm's staining...
  77. pmc Changes in microRNA expression in the whole hippocampus and hippocampal synaptoneurosome fraction following pilocarpine induced status epilepticus
    Rashmi M Risbud
    Division of Pediatric Neurology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 8:e53464. 2013
    ..were performed on rat hippocampus 4 hours, 48 hours and 3 weeks following an episode of pilocarpine induced status epilepticus. Eighty microRNAs increased at one or more of the time points...
  78. ncbi N-methyl-D-asparate receptor antagonists abolish the maintenance phase of self-sustaining status epilepticus in rat
    A M Mazarati
    Department of Neurology and Brain Research Institute, UCLA School of Medicine, Los Angeles, CA, USA
    Neurosci Lett 265:187-90. 1999
    ..acid (AMPA)/kainate receptors on the maintenance of self-sustaining status epilepticus (SSSE) induced in rats by brief intermittent electrical stimulation of the perforant path (PPS)...
  79. doi Are morphologic and functional consequences of status epilepticus in infant rats progressive?
    H Kubova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 4, Czech Republic
    Neuroscience 235:232-49. 2013
    The present study examined whether status epilepticus (SE) induced by LiCl-pilocarpine in immature rats (postnatal day [P]12) interferes with normal development; leads to progressive epileptogenesis, or cognitive decline and to pathology ..
  80. doi Resveratrol pre-treatment reduces early inflammatory responses induced by status epilepticus via mTOR signaling
    Sheng Jun Wang
    Department of Neurology, Qilu Hospital, Shandong University, 107, Wenhua Xi Road, Ji nan 250012, PR China
    Brain Res 1492:122-9. 2013
    ..investigated the role of resveratrol in nuclear factor-kappa B associated inflammatory responses induced by status epilepticus. Our data showed that seizures activated mammalian target of rapamycin (mTOR), increased the activity of ..
  81. ncbi Magnetic resonance imaging findings within 5 days of status epilepticus in childhood
    Rod C Scott
    Great Ormond Street Hospital for Children NHS Trust, Institute of Child Health, University College London, London, UK
    Brain 125:1951-9. 2002
    The nature of the relationships between status epilepticus, acute hippocampal injury, mesial temporal sclerosis (MTS) and temporal lobe epilepsy remains unclear...
  82. doi Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex
    S Chen
    Department of Pharmacology, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan
    Neuroscience 166:341-53. 2010
    ..and excitatory propagation pattern in the IC of rats 4-7 days and 2 months after pilocarpine-induced status epilepticus (4-7 d and 2 m post-SE rats, respectively)...
  83. pmc Frequency and timing of nonconvulsive status epilepticus in comatose post-cardiac arrest subjects treated with hypothermia
    Jon C Rittenberger
    Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neurocrit Care 16:114-22. 2012
    ..However, nonconvulsive status epilepticus (NCSE) may cause persistent coma. The frequency and timing of NCSE after cardiac arrest is unknown.
  84. ncbi Prognosis following Postanoxic Myoclonus Status epilepticus
    Andrew C F Hui
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, SAR, China
    Eur Neurol 54:10-3. 2005
    ..We report a series of patients who developed postanoxic myoclonus status epilepticus (MSE), which was defined as continuous myoclonic seizure activity lasting 30 min or more...
  85. doi Beneficial effects of desacyl-ghrelin, hexarelin and EP-80317 in models of status epilepticus
    Giuseppe Biagini
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy
    Eur J Pharmacol 670:130-6. 2011
    ..activity of ghrelin and other growth hormone secretagogue receptor 1a (GHSR(1a)) ligands in rats exposed to status epilepticus induced by pilocarpine or kainate...
  86. ncbi Repeated low-dose treatment of rats with pilocarpine: low mortality but high proportion of rats developing epilepsy
    M Glien
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, , D-30559 Hannover, Germany
    Epilepsy Res 46:111-9. 2001
    ..is widely used for studying the factors that contribute to the development of epilepsy as a consequence of status epilepticus (SE)...
  87. ncbi Lipid peroxidation in hippocampus early and late after status epilepticus induced by pilocarpine or kainic acid in Wistar rats
    F Dal-Pizzol
    Laboratório de Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, RS, Porto Alegre, Brazil
    Neurosci Lett 291:179-82. 2000
    ..These results indicating a putative role of reactive oxygen species in kainic acid and pilocarpine induced epilepsy...
  88. pmc Inappropriate emergency management of status epilepticus in children contributes to need for intensive care
    R F M Chin
    Neurosciences Unit, Institute of Child Health, University College London, WC1N 1EH, UK
    J Neurol Neurosurg Psychiatry 75:1584-8. 2004
    To characterise the clinical features, emergency pre-paediatric intensive care (PIC) treatment, and course of status epilepticus (SE) in children admitted to PIC...
  89. doi The PPARγ agonist rosiglitazone prevents cognitive impairment by inhibiting astrocyte activation and oxidative stress following pilocarpine-induced status epilepticus
    Sun Hong
    Department of Neurology, The Second Affiliated Hospital, Medical School of Xi an Jiaotong University, NO 157 West 5 Road, Xi an, 710004, Shaanxi Province, China
    Neurol Sci 33:559-66. 2012
    ..cognitive impairment by inhibiting astrocyte activation and regulating glutathione (GSH) homeostasis after status epilepticus (SE)...
  90. pmc MRI abnormalities following febrile status epilepticus in children: the FEBSTAT study
    Shlomo Shinnar
    Neurology and Pediatrics, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Neurology 79:871-7. 2012
    The FEBSTAT study is a prospective study that seeks to determine the acute and long-term consequences of febrile status epilepticus (FSE) in childhood.
  91. doi Predictors and prognosis of status epilepticus treated with intravenous sodium valproate
    Somsak Tiamkao
    Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Epileptic Disord 11:228-31. 2009
    To retrospectively review the efficacy of intravenous sodium valproate (VPAiv) treatment of status epilepticus (SE) and analyse predictive factors for seizure control and death.
  92. doi Status epilepticus-induced pathologic plasticity in a rat model of focal cortical dysplasia
    Francesca Colciaghi
    Molecular Neuroanatomy and Pathogenesis Unit, Neurological Institute C Besta, via Temolo 4, 20126 Milano, Italy
    Brain 134:2828-43. 2011
    ..We induced cortical malformations by exposing rats prenatally to methylazoxymethanol acetate and triggered status epilepticus and recurrent seizures in adult methylazoxymethanol acetate rats with pilocarpine...
  93. doi Bi-lateral changes to hippocampal cholesterol levels during epileptogenesis and in chronic epilepsy following focal-onset status epilepticus in mice
    Maura Heverin
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    Brain Res 1480:81-90. 2012
    ..of seizure-induced brain injury suggest that brain cholesterol levels are altered by prolonged seizures (status epilepticus) and are a feature of the pathophysiology of temporal lobe epilepsy...
  94. ncbi Advances in the pathophysiology of status epilepticus
    J W Y Chen
    Department of Neurology and Brain Research Institute, Geffen School of Medicine at UCLA, and VA Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA
    Acta Neurol Scand 115:7-15. 2007
    b>Status epilepticus (SE) describes an enduring epileptic state during which seizures are unremitting and tend to be self-perpetuating...
  95. ncbi Safety and efficacy of intravenous valproate in pediatric status epilepticus and acute repetitive seizures
    Kian Ti Yu
    Harbor UCLA Medical Center, 1000 W Carson, Box 468, Torrance, CA 90502, USA
    Epilepsia 44:724-6. 2003
    To evaluate the safety and efficacy of intravenous valproate (VPA) loading in children with status epilepticus (SE) or acute repetitive seizures.
  96. ncbi Status epilepticus: pathophysiology and management in adults
    James W Y Chen
    Department of Neurology and Brain Research Institute, Geffen School of Medicine at UCLA, and VA Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA
    Lancet Neurol 5:246-56. 2006
    As in Clark and Prout's classic work, we identify three phases of generalised convulsive status epilepticus, which we call impending, established, and subtle...
  97. ncbi Comparison of status epilepticus models induced by pilocarpine and nerve agents - a systematic review of the underlying aetiology and adopted therapeutic approaches
    F R Tang
    Temasek Laboratories, National University of Singapore, Singapore
    Curr Med Chem 18:886-99. 2011
    ..poisoning, effective neuroprotection in the field remains a challenge amongst subjects with established status epilepticus following nerve agent intoxication...
  98. doi [+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats
    Brian R Coleman
    Department of Biochemical Pharmacology Division of Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    Chem Biol Interact 175:387-95. 2008
    ..Our results suggest that [+]-Hup A protects against seizure and status epilepticus (SE) by blocking NMDA-induced excitotoxicity in vivo...
  99. ncbi Progression of brain damage after status epilepticus and its association with epileptogenesis: a quantitative MRI study in a rat model of temporal lobe epilepsy
    Jaak Nairismägi
    National Bio NMR Facility and Department of Biomedical NMR, University of Kuopio, Kuopio, Finland
    Epilepsia 45:1024-34. 2004
    This study examined the hypothesis that neurodegeneration continues after status epilepticus (SE) ends and that the severity of damage at the early phase of the epileptogenic process predicts the outcome of epilepsy in a long-term follow-..
  100. doi Efficacy of ketogenic diet in severe refractory status epilepticus initiating fever induced refractory epileptic encephalopathy in school age children (FIRES)
    Rima Nabbout
    Department of Neuropediatrics, Centre de Référence Épilepsies Rares, Hopital Necker Enfants Malades, Paris, France
    Epilepsia 51:2033-7. 2010
    ..in school age children (FIRES) is a devastating condition initiated by prolonged perisylvian refractory status epilepticus (SE) triggered by fever of unknown cause...
  101. pmc P2X7 receptor activation ameliorates CA3 neuronal damage via a tumor necrosis factor-α-mediated pathway in the rat hippocampus following status epilepticus
    Ji Eun Kim
    Department of Anatomy and Neurobiology, Institute of Epilepsy Research, College of Medicine, Hallym University, Chunchon, Kangwon Do 200 702, South Korea
    J Neuroinflammation 8:62. 2011
    ..In the present study, we addressed the question of whether P2X7 receptor-mediated TNF-α regulation is involved in pathogenesis and outcome of status epilepticus (SE).

Research Grants74

  1. Genomics of Pediatric Headache Disorders
    Andrew Hershey; Fiscal Year: 2006
    ..microarrays to show that there are unique blood genomic profiles in rats following ischemia, hemorrhage, status epilepticus, and insulin-induced hypoglycemia...
  2. Intranasal CNS delivery of drugs against organophosphorous threat agents
    ARYAN MANGALAM NAMBOODIRI; Fiscal Year: 2013
    ..symptoms of acute CTA poisoning including salivation, lacrimation, defecation, muscular twitching, seizures/status epilepticus and ultimately rapid death due to respiratory failure...
  3. Prostaglandin signaling following seizures
    Jianxiong Jiang; Fiscal Year: 2013
    ..More recently, we have found that pharmacological inhibition of EP2 receptors after pilocarpine-induced status epilepticus in mice provides many beneficial effects including reductions in mortality, weight loss, functional loss, ..
  4. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2010
    ..In experimental animals, all known nerve agents, produce convulsive seizures and status epilepticus within minutes of exposure...
  5. Neuroprotective strategies in seizure-induced damage
    JANA VELISKOVA; Fiscal Year: 2011
    ..Additionally, EB protects against status epilepticus (SE)-induced neuronal damage in the hilus of the hippocampal dentate gyrus...
  6. Subunit dependent properties of kainate receptors
    David D Mott; Fiscal Year: 2013
    ..KAR subunit RNA and protein in the hippocampus during the development of epilepsy after pilocarpine-induced status epilepticus (SE)...
  7. Epigenetic modulation of epileptogenesis.
    PEYMAN GOLSHANI; Fiscal Year: 2010
    ..b>Status epilepticus (SE) causes chronic seizures in animal models...
  8. Novel Treatment Strategies for Targeting Posttraumatic Epilepsy
    Helen M Bramlett; Fiscal Year: 2013
    ..These studies will determine if changes in receptor localization seen after status epilepticus influence the development of seizure susceptibility after TBI...
  9. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2013
    ..We will employ a model of chronic epilepsy that develops in male Wistar rats following pilocarpine - induced status epilepticus (SE)...
  10. Astrocyte Function and Temporal Lobe Epilepsy
    JAY ROBERT VARGAS; Fiscal Year: 2010
    ..We recently discovered that in a rat model of status epilepticus (SE)-induced TLE, reactive astrocytes dramatically increase the expression of a number of kainate receptor (..
  11. CELL BIOLOGY OF THE NEURONAL SODIUM CHANNEL
    William A Catterall; Fiscal Year: 2013
    ..iii) Patients with DS have prolonged episodes of status epilepticus. We will induce status epilepticus in DS mice by thermal stimulation and determine the changes in ..
  12. Calcium Signaling in a Model of Temporal Lobe Epilepsy
    Karen S Wilcox; Fiscal Year: 2013
    ..animal models have been developed that exhibit some of the hallmarks of this seizure disorder: a period of status epilepticus (SE) which serves as the initial insult to the CNS, a variable latent period during which seizures do not ..
  13. Next Generation Oxime Therapeutic for Chemical Agent Inhibited CNS (Brain) ChEs
    Richard K Gordon; Fiscal Year: 2010
    ..distribution in diaphragm, blood, and brain, (d) The most efficacious formulation will be validated in our status epilepticus guinea pig model as a therapy for CNS chemical agent OP-induced toxicity of DFP, GB, GD, and VX using EEC ..
  14. Identifying neurons and circuits critical for epileptogenesis
    Istvan Mody; Fiscal Year: 2013
    ..there is a good correlation between the occurrence of a neurological insult earlier in life (head trauma, status epilepticus, stroke, inflammation, etc.) and the development of TLE after a "latent period"...
  15. Neurobiological basis of Depression as a Comorbidity in Epilepsy
    Andrey M Mazarati; Fiscal Year: 2010
    ..To induce TLE, two weeks-old Wistar rats will be subjected to LiCl and pilocarpine status epilepticus (SE)...
  16. Group I Metabotropic Glutamate Receptors and Epileptogenesis
    Paul A Rutecki; Fiscal Year: 2013
    ..provided by applicant): The development of epilepsy following traumatic brain injury (TBI), stroke, or status epilepticus is a process that involves many mechanisms that provide targets for the prevention of epilepsy...
  17. Validation of High-Throughput Screening of Candidate Antiepileptogenic Drugs
    Andrey Mazarati; Fiscal Year: 2009
    ..The majority of currently available models of epileptogenesis employ a precipitating insult (e.g. status epilepticus, SE), which leads to progressive neurodegenerative and neuronal plastic changes, and culminates in the ..
  18. GABA(A) Receptor Subunit Regulation in Epileptogenesis
    Shelley J Russek; Fiscal Year: 2013
    ..decreases in expression of the a1 gene (Gabra1) in rat hippocampal dentate granule neurons following status epilepticus (SE) that are associated with later development of epilepsy...
  19. Impact of neuronal chloride transport on treatment of seizures.
    Kevin J Staley; Fiscal Year: 2013
    ..available diuretics and inhibitors of cytoskeletal changes might also be useful in the treatment of status epilepticus in both developing and mature nervous systems...
  20. New York-Presbyterian NETT Consortium
    Stephan A Mayer; Fiscal Year: 2011
    ..cardiac arrest, the Merci'clot retriever for acute ischemic stroke, midazolam infusion for refractory status epilepticus, and clinical trials evaluating neuroprotective agents for acute stroke, thrombolytic therapy for ..
  21. Efficacy of GluR5 Antogonists Against Soman-Induced Seizures and Neuropathology
    MARIA F BRAGA; Fiscal Year: 2013
    ..One of the clinical manifestations of exposure to nerve agents is seizure activity and status epilepticus which can lead to death, or brain damage with long-term cognitive/behavioral consequences...
  22. mTOR dysregulation in Epilepsy
    Angela N Carter; Fiscal Year: 2013
    ..lab and others have shown that mTORC1 is altered early following prolonged chemoconvulsant-induced seizures [status epilepticus (SE)] in rodents...
  23. Neonatal EEG Monitor
    Tammy Tsuchida; Fiscal Year: 2012
    ..EEG) is a crucial tool in Neonatal Intensive Care Units (NICU), where it is used to diagnose seizures and status epilepticus and to monitor critically ill neonates...
  24. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2012
    ..The FEBSTAT study examines the consequences of febrile status epilepticus (FSE) and will clarify the relationship between FSE, hippocampal atrophy, MTS, and subsequent epilepsy and ..
  25. Detection and Alerting System for Seizure Onset (DASSO)
    Todd A Summers; Fiscal Year: 2013
    ..Failure to intervene can result in injury during attack, mental impairment or death secondary to status epilepticus, or Sudden Unexplained Death in Epilepsy (SUDEP)...
  26. GABA Receptors and Hilar Neuron Survival in Epilepsy
    Carolyn R Houser; Fiscal Year: 2013
    ..the hypothesis that increasing tonic inhibition in hilar neurons will protect them from damage following status epilepticus. Specific Aim 4 will examine the functional circuitry of hilar neurons in vivo by using optogenetic methods ..
  27. Developing GalR 1/2 Agonists to Treat Nerve Gas Induced Seizure
    Tamas Bartfai; Fiscal Year: 2010
    ..and therapy regimen are not effective for OP-NG induced seizures, which usually progress rapidly into status epilepticus, causing profound brain damage...
  28. A Neurosteroid-based Novel Treatment for OP-Intoxication
    Doodipala Samba Reddy; Fiscal Year: 2012
    ..OP intoxication following exposure to DFP and related military nerve agents results in persistent seizures, status epilepticus (SE) and permanent brain injury...
  29. Molecular Determinants of GABAA Receptor Gene Regulation
    SHELLEY JUNE RUSSEK; Fiscal Year: 2010
    ..in vivo underlie changes in functional properties of dentate granule cells following pilocarpine-induced status epilepticus (SE)...
  30. Treatment of Status Epilepticus: A Translational Proposal
    Claude G Wasterlain; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Treatment Of Status Epilepticus: A Translational Proposal Epilepsy is the most common diagnosis in VA outpatient clinics, and the large number of traumatic brain injuries in OEF/OIF is expected to ..
  31. Neurosteroid Treatment for OP Intoxication
    Doodipala Samba Reddy; Fiscal Year: 2013
    ..Exposure to nerve agents or OP poisoning can result in persistent seizures, status epilepticus (SE), and permanent brain injury...
  32. AGE RELATED SEIZURE SUPPRESSION
    Solomon L Moshe; Fiscal Year: 2011
    ..Epidemiological studies suggest that early in life, the brain is very susceptible to seizures and especially status epilepticus (SE)...
  33. Signaling pathway dysregulation in epilepsy
    Anne E Anderson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Prolonged continuous seizure activity (status epilepticus, SE) is associated with an increased risk for developing epilepsy with hippocampal sclerosis and comorbidities such as long-term cognitive ..
  34. Proneurotrophin signaling in epilepsy
    AJAY THOMAS; Fiscal Year: 2013
    ..The most commonly used animal models of TLE utilize chemoconvulsants to induce prolonged seizures or status epilepticus (SE), which then leads to development of spontaneous recurrent seizures (SRS, epilepsy) after a latent ..
  35. Calcium Signaling in Astrocytes
    KAREN S contact WILCOX; Fiscal Year: 2010
    ..data from age-matched controls, in slices from animals during both the latent period (after induction of status epilepticus but before spontaneous seizures) and after spontaneous seizures have begun...
  36. HCN Channel Trafficking in Epilepsy
    Dane M Chetkovich; Fiscal Year: 2012
    ..of TLE, we found that excitability was reduced and Ih and distal enrichment of HCN1 was enhanced 24h after status epilepticus, a time point before onset of spontaneous seizures (latency)...
  37. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The FEBSTAT study examines the consequences of febrile status epilepticus (FSE) and is clarifying the relationship between FSE, hippocampal atrophy, hippocampal sclerosis (HS), and the development of ..
  38. Modulating ProNGF-induced cell death in Epilepsy: strategies for neuroprotection
    Helen E Scharfman; Fiscal Year: 2013
    ..role of neurotrophins, particularly proNGF in mediating neuronal apoptosis following severe seizures (status epilepticus;SE)...
  39. A Novel Mouse Model of Temporal Lobe Epilepsy
    Karen S Wilcox; Fiscal Year: 2013
    ..Viral infections of the central nervous system (CNS) are associated with an increased risk for seizures, status epilepticus (SE), and the development of chronic epilepsy...
  40. Perisomatic Inhibitory Network Dysfunction in Neurological Disease
    Vijayalakshmi Santhakumar; Fiscal Year: 2013
    ..Understanding how activity patterns in the perisomatic inhibitory network are altered following status epilepticus and dynamically regulated during seizures will help evaluate whether pharmacological manipulation of gap ..
  41. Rat transcriptome biomarkers for the prediction of temporal lobe epilepsy
    STANISLAV KARSTEN; Fiscal Year: 2009
    b>Status epilepticus (SE) is a common cause of hippocampal neurodegeneration and synaptic reorganization that ultimately may, or may not lead to the development of temporal lobe epilepsy (TLE)...
  42. PARP-1 activation in seizures and status epilepticus
    Yi Chen Lai; Fiscal Year: 2013
    ..His main research interest is status epilepticus, a prevalent disease of childhood associated with significant mortality and morbidity...
  43. Role of zinc in regulating axo-dendritic chloride following status epilepticus
    Daniel L Jones; Fiscal Year: 2011
    ..are important in maintaining proper levels of excitation in the brain, and are often disrupted following status epilepticus. The efficacy of synaptic inhibition, provided by inhibitory interneurons that release the neurotransmitter ..
  44. Neuronal Loss and Plasticity in Epilepsy
    Carolyn R Houser; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abstract A severe brain insult such as status epilepticus or traumatic brain injury has the potential for producing epilepsy later in life...
  45. Anticonvulsant effects of novel concentric ring electrode electrical stimulation
    WALTER GRANT BESIO; Fiscal Year: 2010
    ..Hypothesis 2: {The suppression of pilocarpine (PILO)-induced status epilepticus (SE) by TcES via concentric ring electrodes reduces SE-provoked neuronal death...
  46. STATUS EPILEPTICUS REORGANIZES CANNABINOID RECEPTORS
    ROBERT JOHN DELORENZO; Fiscal Year: 2010
    ..Our laboratory has demonstrated that one hour of prolonged seizures (status epilepticus, SE) in the pilocarpine model of SE produces a long-term reorganization in the expression of the CB1 ..
  47. Canine Status Epilepticus: A Translational Platform for Human Therapeutic Trials
    Ilo E Leppik; Fiscal Year: 2011
    ..subsequent projects that will facilitate the translation of new drugs discovered from laboratory models of status epilepticus to treatment of human status epilepticus (HSE)...
  48. Seizure-induced Neuronal Loss and Epileptogenesis in the Immature Brain
    JEFFREY JOHN EKSTRAND; Fiscal Year: 2013
    ..the lithium pilocarpine (LiPC) animal model of epilepsy, a well established model of chemoconvulsant status epilepticus (SE), to reexamine whether prolonged seizures result in the development of epilepsy in immature animals, and,..
  49. Roles for gliotransmisssion in seizure-related disorders
    Philip G Haydon; Fiscal Year: 2010
    ..b>Status epilepticus, a period of repeated often intractable seizures, is followed by a latent period of epileptogenesis during ..
  50. Contributions of aberrant granule cell integration to the development of epilepsy
    Steve C Danzer; Fiscal Year: 2013
    ..Epilepsy frequently develops following neurological injuries such as head trauma, hypoxia or status epilepticus. Abnormal integration of new brain cells may result as a direct consequence of this initial injury...
  51. Aberrant Neurogenesis in Experimental Temporal Lobe Epilepsy
    Jack M Parent; Fiscal Year: 2013
    ..integrated adult-born DGCs compensate for epileptogenic hyperexcitability by restoring inhibition after status epilepticus (SE)-induced injury...
  52. CRE Mediated Transcription in Epileptogenesis
    Brenda E Porter; Fiscal Year: 2012
    ..We will induce a long seizure called status epilepticus (SE) to induce the development of epilepsy or spontaneous seizures...
  53. Drosophila Bang-sensitive Paralytic Mutants
    Mark A Tanouye; Fiscal Year: 2013
    ..6y;SMEI (severe myoclonic epilepsy in infancy), an intractable epilepsy frequently resulting in convulsive status epilepticus;and ICEGTC (intractable childhood epilepsy with generalized tonic-clonic), an atypical SMEI that does not ..
  54. Prevention of Temporal Lobe Epilepsy
    James O McNamara; Fiscal Year: 2013
    ..Clinical observations as well as studies of diverse animal models underlie the idea that febrile status epilepticus (FSE) in childhood can cause TLE later in life...
  55. UK NETT Clinical Site Hub
    ROGER LOYD HUMPHRIES; Fiscal Year: 2013
    ..lorazepam in status epilepticus), ALIAS Part 2 (albumin v...
  56. Mechanisms of hippocampal excitotoxic cell death and structural remodeling
    Karl H Obrietan; Fiscal Year: 2010
    ..In this aim, we will characterize the temporal and cell-type specific expression of status epilepticus-(SE) induced MAPK pathway activation in the hippocampus, and then determine whether MAPK signaling confers ..
  57. Role of COX2 of Neuronal Origin in Blood-Brain Communication after status epilept
    Raymond J Dingledine; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Status epilepticus (SE) in man and rodents can produce cognitive deficits and trigger a series of molecular and cellular events that eventually culminate in the appearance of spontaneous seizures, i.e...
  58. Autonomic consequences of brief seizures
    Mark Stewart; Fiscal Year: 2004
    ..dysfunction with increasing seizure intensity, sudden death during a seizure is not limited to cases of status epilepticus or even generalized tonic-clonic seizures...
  59. Patients' Experiences of Emergency Research (PEER)- Views of Patients included in
    Rebecca D Pentz; Fiscal Year: 2010
    ..need for clinical research on treatment of acute neurological conditions such as traumatic brain injury, status epilepticus, and stroke...
  60. Regulation of epileptogenesis by the transcriptional repressor, REST
    Jenny Hsieh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Status epilepticus (SE) in man and rodents can produce cognitive deficits and trigger a series of molecular and cellular events that eventually culminate in the appearance of spontaneous seizures, i.e...
  61. Galanin, Seizures, and Neuroinflammation
    Marc Scott Weinberg; Fiscal Year: 2013
    ..adeno-associated galanin vector to susceptible brain areas shortly following chemiconvulsant-induced status epilepticus can ameliorate the ensuing neurodegeneration and / or neuroinflammation following insult...
  62. Prostanoid Modulators that Reduce Brain Injury After Seizures
    Raymond J Dingledine; Fiscal Year: 2013
    ..Therapies that can be administered hours after chemical exposure are needed. Prolonged status epilepticus (SE) induced by the muscarinic agonist, pilocarpine, or the organophosphate, diisopropyl fluorophosphate (..
  63. Astrocyte dysfunction in epileptogenesis: the role of adenosine
    Detlev Boison; Fiscal Year: 2013
    ..This proposal will explore status epilepticus (SE)- triggered epileptogenesis and dysfunction of the endogenous adenosine-based seizure control system in ..
  64. GABAA RECEPTOR CHANNEL ALTERATION BY PROLONGED SEIZURES
    Robert MacDonald; Fiscal Year: 2003
    ..during some seizures, early termination fails and a prolonged epileptic state occurs that has been termed status epilepticus. Status epilepticus is relatively common, has a high morbidity and mortality and is a medical emergency ..
  65. GABA-A Receptor Gene Transfer to Prevent Epileptogenesis
    SHELLEY RUSSEK; Fiscal Year: 2004
    ..about the genetic mechanisms that regulate granule cells of adult rats following pilocarpine-induced status epilepticus (SE), it has yet to be demonstrated that these changes are either necessary or sufficient for the ..
  66. OXIDATIVE STRESS IN SEIZURE INDUCED NEURONAL INJURY
    WOLF DIETRICH DETTBARN; Fiscal Year: 1999
    ..production of radical oxygen species (ROS) are proposed to be implicated in the series of events linking status epilepticus with neuronal injury. One of the well-recognized targets of ROS-induced injury is peroxidation of lipids...
  67. The Medial Entorhinal Cortex and Temporal Lobe Epilepsy
    KAREN WILCOX; Fiscal Year: 2007
    ..mEC-HC brain slice preparation obtained from control rats and those subjected to the kainic acid-induced status epilepticus (SE) model of TLE (Aims 2 & 3) to perform the following specific aims: 1) Compare and contrast the ..
  68. Astrocytes and temporal lobe epilepsy
    KAREN WILCOX; Fiscal Year: 2009
    ..animal models have been developed that exhibit some of the hallmarks of this seizure disorder: a period of status epilepticus (SE) which serves as the initial insult to the CNS, a variable latent period during which seizures do not ..
  69. Pharmacoresistance in rats with kainate-induced epilepsy
    F Dudek; Fiscal Year: 2005
    ..with spontaneous recurrent seizures, following a latent period from electrically or chemically induced status epilepticus, may be useful for identifying new AED for the pharmacoresistant population...
  70. Status Epilepticus Outcomes in the United States
    Edwin Trevathan; Fiscal Year: 2001
    DESCRIPTION: (taken from abstract) Status epilepticus (SE) is a common, life- threatening medical emergency that is experienced by about 150,000 people in the United States (US) each year, with up to 40,000 SE-associated deaths...
  71. LITHIUM POTENTIATED STATUS EPILEPTICUS
    RICHARD JOPE; Fiscal Year: 1990
    This project uses electrophysiological and biochemical methods to study a new model of status epilepticus. This model uses pretreatment with lithium followed by administration of subthreshold doses of convulsants...
  72. Signaling mechanisms underlying VEGF-induced neuroprotection in vivo
    Susan Croll; Fiscal Year: 2007
    ..VEGF also protects neurons in models of cell death in vivo. One such model is the pilocarpine-induced status epilepticus model, in which cell damage occurs within days after a single, prolonged status epilepticus event...
  73. Epileptogenesis after febrile status epilepticus: a role of hyperthermia
    Claude Wasterlain; Fiscal Year: 2009
    ..tell us if correcting hyperthermia after the first seizure reduces the long-term consequences of febrile status epilepticus (epileptogenesis and brain damage)...
  74. Mechanisms of regulation of excitability in immature CNS
    Joaquin N Lugo; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Prolonged, continuous seizure activity (status epilepticus) is associated with significant mortality and morbidity, particularly in children...