cerebral palsy

Summary

Summary: A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)

Top Publications

  1. ncbi A report: the definition and classification of cerebral palsy April 2006
    Peter Rosenbaum
    CanChild Centre for Childhood Disability Research, Hamilton, Ontario, Canada
    Dev Med Child Neurol Suppl 109:8-14. 2007
  2. ncbi Proposed definition and classification of cerebral palsy, April 2005
    Martin Bax
    Division of Paediatrics, Obstetrics and Gynaecology, Imperial College, London, UK
    Dev Med Child Neurol 47:571-6. 2005
  3. ncbi Use of a low-cost, commercially available gaming console (Wii) for rehabilitation of an adolescent with cerebral palsy
    Judith E Deutsch
    Department of Rehabilitation and Movement Science, School of Health Related Professions, University of Medicine and Dentistry of New Jersey, 65 Bergen St, SSB 723, Newark, NJ 07101 3001, USA
    Phys Ther 88:1196-207. 2008
  4. ncbi The Manual Ability Classification System (MACS) for children with cerebral palsy: scale development and evidence of validity and reliability
    Ann Christin Eliasson
    Neuropaediatric Research Unit, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Dev Med Child Neurol 48:549-54. 2006
  5. ncbi Chorioamnionitis as a risk factor for cerebral palsy: A meta-analysis
    Y W Wu
    Department of Neurology, University of California, PO Box 0114, San Francisco, CA 94143 0114, USA
    JAMA 284:1417-24. 2000
  6. ncbi Medial gastrocnemius muscle volume and fascicle length in children aged 2 to 5 years with cerebral palsy
    Lee Barber
    Griffith Health Institute, Griffith University, Gold Coast Campus, Queensland, Australia
    Dev Med Child Neurol 53:543-8. 2011
  7. ncbi MRI structural connectivity, disruption of primary sensorimotor pathways, and hand function in cerebral palsy
    Stephen Rose
    University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia
    Brain Connect 1:309-16. 2011
  8. ncbi Neurodevelopmental disability through 11 years of age in children born before 26 weeks of gestation
    Samantha Johnson
    Neonatology, Institute for Women s Health, University College London, London, United Kingdom
    Pediatrics 124:e249-57. 2009
  9. ncbi Repeated antenatal corticosteroids: effects on cerebral palsy and childhood behavior
    Noel P French
    Department of Neonatal Paediatrics, King Edward Memorial Hospital, Subiaco, Perth, Australia
    Am J Obstet Gynecol 190:588-95. 2004
  10. ncbi Placental lesions as predictors of cerebral palsy and abnormal neurocognitive function at school age in extremely low birth weight infants (<1 kg)
    Raymond W Redline
    Department of Pathology, Case School of Medicine and Rainbow Babies and Children s Hospital, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Pediatr Dev Pathol 10:282-92. 2007

Detail Information

Publications376 found, 100 shown here

  1. ncbi A report: the definition and classification of cerebral palsy April 2006
    Peter Rosenbaum
    CanChild Centre for Childhood Disability Research, Hamilton, Ontario, Canada
    Dev Med Child Neurol Suppl 109:8-14. 2007
    For a variety of reasons, the definition and the classification of cerebral palsy (CP) need to be reconsidered...
  2. ncbi Proposed definition and classification of cerebral palsy, April 2005
    Martin Bax
    Division of Paediatrics, Obstetrics and Gynaecology, Imperial College, London, UK
    Dev Med Child Neurol 47:571-6. 2005
    ..therapy for the consequences of injury, the need for reconsideration of the definition and classification of cerebral palsy (CP) has become evident...
  3. ncbi Use of a low-cost, commercially available gaming console (Wii) for rehabilitation of an adolescent with cerebral palsy
    Judith E Deutsch
    Department of Rehabilitation and Movement Science, School of Health Related Professions, University of Medicine and Dentistry of New Jersey, 65 Bergen St, SSB 723, Newark, NJ 07101 3001, USA
    Phys Ther 88:1196-207. 2008
    The purpose of this retrospective and prospective case report is to describe the feasibility and outcomes of using a low-cost, commercially available gaming system (Wii) to augment the rehabilitation of an adolescent with cerebral palsy.
  4. ncbi The Manual Ability Classification System (MACS) for children with cerebral palsy: scale development and evidence of validity and reliability
    Ann Christin Eliasson
    Neuropaediatric Research Unit, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Dev Med Child Neurol 48:549-54. 2006
    The Manual Ability Classification System (MACS) has been developed to classify how children with cerebral palsy (CP) use their hands when handling objects in daily activities...
  5. ncbi Chorioamnionitis as a risk factor for cerebral palsy: A meta-analysis
    Y W Wu
    Department of Neurology, University of California, PO Box 0114, San Francisco, CA 94143 0114, USA
    JAMA 284:1417-24. 2000
    Chorioamnionitis has been implicated in the pathogenesis of cerebral palsy, but most studies have not reported a significant association...
  6. ncbi Medial gastrocnemius muscle volume and fascicle length in children aged 2 to 5 years with cerebral palsy
    Lee Barber
    Griffith Health Institute, Griffith University, Gold Coast Campus, Queensland, Australia
    Dev Med Child Neurol 53:543-8. 2011
    ..area (PCSA), muscle length, fascicle length, and pennation angle in children aged 2 to 5 years with spastic cerebral palsy (CP) and in typically developing children...
  7. ncbi MRI structural connectivity, disruption of primary sensorimotor pathways, and hand function in cerebral palsy
    Stephen Rose
    University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia
    Brain Connect 1:309-16. 2011
    ....
  8. ncbi Neurodevelopmental disability through 11 years of age in children born before 26 weeks of gestation
    Samantha Johnson
    Neonatology, Institute for Women s Health, University College London, London, United Kingdom
    Pediatrics 124:e249-57. 2009
    ..To assess functional disability in children born before 26 weeks of gestation at 11 years of age and the stability of findings in individuals between 6 and 11 years of age...
  9. ncbi Repeated antenatal corticosteroids: effects on cerebral palsy and childhood behavior
    Noel P French
    Department of Neonatal Paediatrics, King Edward Memorial Hospital, Subiaco, Perth, Australia
    Am J Obstet Gynecol 190:588-95. 2004
    This study was undertaken to determine the effects of repeated courses of antenatal corticosteroids on childhood behavior and disabilities, including cognitive delay and cerebral palsy.
  10. ncbi Placental lesions as predictors of cerebral palsy and abnormal neurocognitive function at school age in extremely low birth weight infants (<1 kg)
    Raymond W Redline
    Department of Pathology, Case School of Medicine and Rainbow Babies and Children s Hospital, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Pediatr Dev Pathol 10:282-92. 2007
    ..pathology in a cohort study of inborn singleton ELBW infants born between 1992 and 1995 and evaluated for cerebral palsy (CP) and abnormal neurocognitive testing at 8 years of age (N = 129)...
  11. ncbi Transition to adulthood: validation of the Rotterdam Transition Profile for young adults with cerebral palsy and normal intelligence
    Mireille Donkervoort
    Department of Rehabilitation Medicine, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    Dev Med Child Neurol 51:53-62. 2009
    ..Transition Profile (RTP) to describe the transition process from childhood to adulthood in young adults with cerebral palsy (CP). Participants were recruited from rehabilitation centres and hospital departments of rehabilitation...
  12. ncbi Botulinum toxin assessment, intervention and after-care for lower limb spasticity in children with cerebral palsy: international consensus statement
    S C Love
    Centre for Musculoskeletal Studies, University of Western Australia, Princess Margaret Hospital, Perth, Western Australia, Australia
    Eur J Neurol 17:9-37. 2010
    ..has been used in association with other interventions in the management of spasticity in children with cerebral palsy (CP) for almost two decades...
  13. ncbi Gross muscle morphology and structure in spastic cerebral palsy: a systematic review
    Rod S Barrett
    School of Physiotherapy and Exercise Science, Griffith Health, Griffith University, Queensland, Australia
    Dev Med Child Neurol 52:794-804. 2010
    This systematic review and critical evaluation of the literature was conducted to determine how gross muscle morphology and structure are altered in individuals with spastic cerebral palsy (CP).
  14. ncbi Pain in children with cerebral palsy: a cross-sectional multicentre European study
    K N Parkinson
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    Acta Paediatr 99:446-51. 2010
    To determine the prevalence and associations of self-reported and parent-reported pain in children with cerebral palsy (CP) of all severities.
  15. ncbi A systematic review of interventions for children with cerebral palsy: state of the evidence
    Iona Novak
    Cerebral Palsy Alliance, Sydney, Australia University of Notre Dame Australia, Sydney, Australia
    Dev Med Child Neurol 55:885-910. 2013
    The aim of this study was to describe systematically the best available intervention evidence for children with cerebral palsy (CP).
  16. ncbi The changing panorama of cerebral palsy in Sweden. X. Prevalence and origin in the birth-year period 1999-2002
    K Himmelmann
    Queen Silvia Children s Hospital, Sahlgrenska Academy at the University of Gothenburg, Goteborg, Sweden
    Acta Paediatr 99:1337-43. 2010
    The aim of the study was to describe the prevalence and origin of cerebral palsy (CP), which is the tenth report from the western Swedish study.
  17. ncbi Occupational therapy home programs for cerebral palsy: double-blind, randomized, controlled trial
    Iona Novak
    Cerebral Palsy Institute, School of Medicine Sydney, University of Notre Dame Australia, Sydney, Australia
    Pediatrics 124:e606-14. 2009
    ..therapy home program (OTHP), compared with no OTHP, with respect to function and parent satisfaction with child function, participation, goal attainment, and quality of upper limb skill in school-aged children with cerebral palsy.
  18. ncbi Cerebral palsy and fetal inflammatory response syndrome: a review
    Asher Bashiri
    Department of Obstetrics and Gynecology, Soroka University Medical Center, PO Box 151, Beer Sheva, Israel
    J Perinat Med 34:5-12. 2006
    b>Cerebral palsy (CP) is the most common cause of severe physical disability in childhood...
  19. ncbi The prevalence, distribution, and effect of pain among adolescents with cerebral palsy
    Samantha Doralp
    Faculty of Health Sciences, The University of Western Ontario, London, Ontario, Canada N6G 1H1
    Pediatr Phys Ther 22:26-33. 2010
    To describe the prevalence, distribution, and intensity of pain and determine the relationship between pain intensity and effect on daily activities in adolescents with cerebral palsy.
  20. ncbi Statistical spatial filtering for a P300-based BCI: tests in able-bodied, and patients with cerebral palsy and amyotrophic lateral sclerosis
    Gabriel Pires
    Institute for Systems and Robotics ISR, University of Coimbra, 3030 290 Coimbra, Portugal
    J Neurosci Methods 195:270-81. 2011
    ..The system was tested by three subjects with cerebral palsy (CP), two subjects with amyotrophic lateral sclerosis (ALS), and nineteen able-bodied subjects...
  21. ncbi Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy?
    Bobbi Fleiss
    Centre for the Developing Brain, Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Imperial College, Hammersmith Campus, London, UK
    Lancet Neurol 11:556-66. 2012
    b>Cerebral palsy is caused by injury or developmental disturbances to the immature brain and leads to substantial motor, cognitive, and learning deficits...
  22. ncbi New insights into the pathology of white matter tracts in cerebral palsy from diffusion magnetic resonance imaging: a systematic review
    Simon M Scheck
    UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia
    Dev Med Child Neurol 54:684-96. 2012
    ..To evaluate its role in the research domain, we systematically reviewed the literature about children with cerebral palsy (CP) to document common findings and identify strengths and possible limitations of this neuroimaging ..
  23. ncbi The energy expenditure of normal and pathologic gait
    R L Waters
    Rancho Los Amigos Medical Center, 7601 E Imperial Highway, Downey, CA 90242, USA
    Gait Posture 9:207-31. 1999
    ..This paper also will examine the effectiveness of rehabilitation interventions at mitigating the energetic penalties of disability during ambulation...
  24. pmc Adaptor protein complex-4 (AP-4) deficiency causes a novel autosomal recessive cerebral palsy syndrome with microcephaly and intellectual disability
    Andres Moreno-De-Luca
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA
    J Med Genet 48:141-4. 2011
    b>Cerebral palsy is a heterogeneous group of neurodevelopmental brain disorders resulting in motor and posture impairments often associated with cognitive, sensorial, and behavioural disturbances...
  25. ncbi Intrauterine infection and the development of cerebral palsy
    Bo Hyun Yoon
    Department of Obstetrics and Gynaecology, Seoul National University College of Medicine, Seoul, South Korea
    BJOG 110:124-7. 2003
    b>Cerebral palsy is a serious motor disorder that appears in early life. The expectation that improved obstetrical and neonatal care would decrease the rate of this condition has not been realised...
  26. pmc Voluntary muscle activation, contractile properties, and fatigability in children with and without cerebral palsy
    Scott K Stackhouse
    Program in Biomechanics and Movement Science, University of Delaware, Newark, Delaware, USA
    Muscle Nerve 31:594-601. 2005
    b>Cerebral palsy (CP) may lead to profound weakness in affected portions of the extremities and trunk...
  27. ncbi Altered inflammatory responses in preterm children with cerebral palsy
    Chang Yi Lin
    Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan, Taiwan
    Ann Neurol 68:204-12. 2010
    Perinatal inflammatory responses contribute to periventricular leukomalacia (PVL) and cerebral palsy (CP) in preterm infants. Here, we examined whether preterm children with CP had altered inflammatory responses when school-aged.
  28. ncbi Progressive bone and joint abnormalities of the spine and lower extremities in cerebral palsy
    David S Morrell
    Department of Radiology, Oregon Health Sciences University, Mail Code L340, 3181 SW Sam Jackson Park Rd, Portland, OR 97201, USA
    Radiographics 22:257-68. 2002
    Bone and joint changes in cerebral palsy result from muscle spasticity and contracture. The spine and the joints of the lower extremity are most commonly affected. Scoliosis may progress rapidly and may continue after skeletal maturity...
  29. ncbi The epidemiology of cerebral palsy: incidence, impairments and risk factors
    Else Odding
    Dept of Rehabilitation Medicine, Erasmus MC University Medical Centre Rotterdam, 3000 CA Rotterdam, The Netherlands
    Disabil Rehabil 28:183-91. 2006
    Describing the epidemiology of cerebral palsy (CP), its impairments and risk factors.
  30. ncbi Cerebral palsy
    L Andrew Koman
    Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston Salem, NC 27157 1070, USA
    Lancet 363:1619-31. 2004
    b>Cerebral palsy, a range of non-progressive syndromes of posture and motor impairment, is a common cause of disability in childhood...
  31. pmc A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy
    Dwight J Rouse
    University of Alabama at Birmingham, Birmingham, USA
    N Engl J Med 359:895-905. 2008
    Research suggests that fetal exposure to magnesium sulfate before preterm birth might reduce the risk of cerebral palsy.
  32. ncbi To constrain or not to constrain, and other stories of intensive upper extremity training for children with unilateral cerebral palsy
    Andrew M Gordon
    Department of Biobehavioral Sciences, Teachers College, Columbia University, New York 10027, USA
    Dev Med Child Neurol 53:56-61. 2011
    Impaired hand function is among the most functionally disabling symptoms of unilateral cerebral palsy. Evidence-based treatment approaches are generally lacking...
  33. ncbi Development of a condition-specific measure of quality of life for children with cerebral palsy: empirical thematic data reported by parents and children
    E Waters
    School of Health and Social Development, Faculty of Health and Behavioural Sciences, Deakin University, Melbourne, Victoria, Australia
    Child Care Health Dev 31:127-35. 2005
    ..health-related quality of life (HRQOL) are important outcome variables in clinical trials for children with cerebral palsy, there are substantial limitations in existing measures of QOL...
  34. ncbi Hand function in relation to brain lesions and corticomotor-projection pattern in children with unilateral cerebral palsy
    Linda Holmström
    Department of Woman and Child Health, Karolinska Institutet Karolinska University Hospital, Stockholm, Sweden
    Dev Med Child Neurol 52:145-52. 2010
    To investigate relationships between hand function, brain lesions, and corticomotor projections in children with unilateral cerebral palsy (CP).
  35. pmc Postural muscle dyscoordination in children with cerebral palsy
    Jolanda C van der Heide
    Department of Neurology, University of Groningen, The Netherlands
    Neural Plast 12:197-203; discussion 263-72. 2005
    ..of the knowledge currently available on muscular dyscoordination underlying postural problems in children with cerebral palsy (CP)...
  36. ncbi The epidemiology and causes of cerebral palsy
    Dinah S Reddihough
    Royal Childrens Hospital, Melbourne
    Aust J Physiother 49:7-12. 2003
    b>Cerebral palsy is the commonest physical disability in childhood, occurring in 2.0 to 2.5 per 1000 live births...
  37. ncbi Probability of walking in children with cerebral palsy in Europe
    Eva Beckung
    Queen Silvia Children s Hospital Sahlgrenska, University of Goteborg, Goteborg, Sweden
    Pediatrics 121:e187-92. 2008
    The purpose of this work was to describe walking ability in children with cerebral palsy from the Surveillance of Cerebral Palsy in Europe common database through 21 years and to examine the association between walking ability and ..
  38. ncbi Gait classification in children with cerebral palsy: a systematic review
    Fiona Dobson
    Hugh Williamson Gait Laboratory and Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville, VIC 3052, Australia
    Gait Posture 25:140-52. 2007
    ..of the literature evaluates the validity of existing classifications of gait deviations in children with cerebral palsy (CP)...
  39. ncbi Increased risk of adverse neurological development for late preterm infants
    Joann R Petrini
    Perinatal Data Center, March of Dimes National Office, White Plains, NY 10605, USA
    J Pediatr 154:169-76. 2009
    To assess the risks of moderate prematurity for cerebral palsy (CP), developmental delay/mental retardation (DD/MR), and seizure disorders in early childhood.
  40. ncbi Relationship between attrition and neurodevelopmental impairment rates in extremely preterm infants at 18 to 24 months: a systematic review
    Ursula Guillen
    Division of Neonatology, The Children s Hospital of Philadelphia, PA 19104, USA
    Arch Pediatr Adolesc Med 166:178-84. 2012
    ..To assess the effect of loss to follow-up rates at 18 to 24 months on neurodevelopmental outcome statistics for infants of less than 1000 g birth weight or less than 28 weeks' gestational age...
  41. ncbi Interleukin-6 genotype and risk for cerebral palsy in term and near-term infants
    Yvonne W Wu
    Department of Neurology, University of California, San Francisco, San Francisco, CA 94143 0137, USA
    Ann Neurol 66:663-70. 2009
    Chorioamnionitis is associated with increased risk for cerebral palsy (CP) in term infants. A functional polymorphism in the interleukin-6 (IL-6) gene has been implicated in newborn brain injury...
  42. ncbi The health of primary caregivers of children with cerebral palsy: how does it compare with that of other Canadian caregivers?
    Jamie C Brehaut
    Clinical Epidemiology Unit, Ottawa Health Research Institute, Ottawa Hospital, Ottawa, Ontario, Canada
    Pediatrics 114:e182-91. 2004
    ..The goal of this study was to compare the physical and psychologic health of CGs of children with cerebral palsy (CP) with that of the general population of CGs.
  43. ncbi Towards an intelligent wheelchair system for users with cerebral palsy
    Luis Montesano
    Department de Informática e Ingeniería de Sistemas, Universidad de Zaragoza, Zaragoza, Spain
    IEEE Trans Neural Syst Rehabil Eng 18:193-202. 2010
    ..The study focuses on patients with cerebral palsy, one of the most common disorders affecting muscle control and coordination, thereby impairing movement...
  44. pmc Clinical management of spasticity
    A J Thompson
    J Neurol Neurosurg Psychiatry 76:459-63. 2005
  45. ncbi Mental health, health related quality of life and recurrent musculoskeletal pain in children with cerebral palsy 8-18 years old
    Kjersti Ramstad
    Department of Clinical Neuroscience, Division of Women and Children, Oslo University Hospital, Norway
    Disabil Rehabil 34:1589-95. 2012
    To extend knowledge on mental health with children's self-report and explore mental health and health related quality of life (HRQL) in a context of recurrent musculoskeletal pain in cerebral palsy (CP).
  46. pmc Quantitative analysis of brain pathology based on MRI and brain atlases--applications for cerebral palsy
    Andreia V Faria
    The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuroimage 54:1854-61. 2011
    We have developed a new method to provide a comprehensive quantitative analysis of brain anatomy in cerebral palsy patients, which makes use of two techniques: diffusion tensor imaging and automated 3D whole brain segmentation based on ..
  47. ncbi The effect of lower extremity selective voluntary motor control on interjoint coordination during gait in children with spastic diplegic cerebral palsy
    Eileen G Fowler
    Department of Orthopaedic Surgery, University of California at Los Angeles, Los Angeles, CA 90095, United States
    Gait Posture 29:102-7. 2009
    Damage to motor tracts in the periventricular white matter is a primary etiology in spastic diplegic cerebral palsy (CP). These tracts are responsible for the production of selective voluntary motor control (SVMC)...
  48. ncbi Responsiveness of Goal Attainment Scaling in comparison to two standardized measures in outcome evaluation of children with cerebral palsy
    Duco Steenbeek
    Revant Rehabilitation Centre Breda, The Netherlands
    Clin Rehabil 25:1128-39. 2011
    ..To assess the responsiveness of Goal Attainment Scaling compared with the Pediatric Evaluation of Disability Inventory (PEDI) and the 66-item Gross Motor Function Measure (GMFM-66) in multidisciplinary rehabilitation practice...
  49. ncbi The dynamic balance of the children with cerebral palsy and typical developing during gait. Part I: Spatial relationship between COM and COP trajectories
    Bih Jen Hsue
    Institute of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan
    Gait Posture 29:465-70. 2009
    ..Dynamic stability of 32 children with cerebral palsy (CP) was examined and compared with 10 typically developing (TD) children by measuring the displacement of ..
  50. ncbi Virtual reality in pediatric neurorehabilitation: attention deficit hyperactivity disorder, autism and cerebral palsy
    Michelle Wang
    Virtual Reality and Neurorehabilitation Laboratory, Department of Rehabilitation Science, University of Toronto, Toronto, Ont, Canada
    Neuroepidemiology 36:2-18. 2011
    ..and use of virtual reality (VR) for children with attention deficit hyperactivity disorder (ADHD), autism and cerebral palsy. This literature review explores how VR systems have been used as treatment tools to address the primary ..
  51. ncbi The changing panorama of cerebral palsy in Sweden. IX. Prevalence and origin in the birth-year period 1995-1998
    K Himmelmann
    The Queen Silvia Children s Hospital, Goteborg University, Goteborg, Sweden
    Acta Paediatr 94:287-94. 2005
    This is the ninth report from the western-Swedish study of the prevalence and origin of cerebral palsy.
  52. ncbi Capacity, capability, and performance: different constructs or three of a kind?
    Laura Holsbeeke
    Rehabilitation Center De Hoogstraat, Center of Excellence for Rehabilitation Medicine, Utrecht, The Netherlands
    Arch Phys Med Rehabil 90:849-55. 2009
    The present study focused on motor activities of young children with cerebral palsy (CP) and examined the relation between motor capacity (what a person can do in a standardized, controlled environment), motor capability (what a person ..
  53. ncbi Outcomes at 2 years of age after repeat doses of antenatal corticosteroids
    Caroline A Crowther
    Disciplines of Obstetrics and Gynaecology, University of Adelaide, Women s and Children s Hospital, Adelaide, Australia
    N Engl J Med 357:1179-89. 2007
    ..However, data have not been available regarding longer-term effects of this treatment...
  54. ncbi Quantitative diffusion tensor imaging in cerebral palsy due to periventricular white matter injury
    Bejoy Thomas
    Department of Radiology, University Hospitals, KUL, Leuven, Belgium
    Brain 128:2562-77. 2005
    ..and secondary degenerative changes in cerebral white matter and deep grey matter in patients with spastic cerebral palsy due to PWI and to look for any possible reorganization of the axonal architecture...
  55. pmc Motor cortical functional geometry in cerebral palsy and its relationship to disability
    T M Kesar
    Dept of Physical Therapy, University of Delaware, Newark, DE, United States
    Clin Neurophysiol 123:1383-90. 2012
    To investigate motor cortical map patterns in children with diplegic and hemiplegic cerebral palsy (CP), and the relationships between motor cortical geometry and motor function in CP.
  56. ncbi The relationship between early concentrations of 25 blood proteins and cerebral white matter injury in preterm newborns: the ELGAN study
    Alan Leviton
    Neuroepidemiology Unit, Department of Neurology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    J Pediatr 158:897-903.e1-5. 2011
    ..To evaluate whether concentrations of inflammation-related proteins are elevated in the blood of preterm newborns who develop cerebral white matter damage...
  57. ncbi Architecture of the medial gastrocnemius in children with spastic diplegia
    Adam P Shortland
    One Small Step Gait Laboratory, Guy s Hospital, London, UK
    Dev Med Child Neurol 44:158-63. 2002
    ..We suggest that muscle contracture may be better explained in terms of shortness of the aponeuroses of pennate muscles, such as the medial gastrocnemius, through reduced muscle fibre diameter...
  58. ncbi Genetics considerations in cerebral palsy
    G Bradley Schaefer
    University of Nebraska Medical Center, Munroe Meyer Institute for Rehabilitation and Genetics Medicine, Omaha, NE 68198 5430, USA
    Semin Pediatr Neurol 15:21-6. 2008
    b>Cerebral palsy refers to a collective of neurologic conditions that share in common disorders of motor function and posture. Traditionally, and still today in many circles, the term is considered almost synonymous with brain injury...
  59. ncbi Effect of treadmill training with body weight support on gait and gross motor function in children with spastic cerebral palsy
    Rong Ju Cherng
    Department of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Am J Phys Med Rehabil 86:548-55. 2007
    To examine the effect of treadmill training with body weight support (TBWS) on gait and gross motor function in children with spastic cerebral palsy (CP).
  60. ncbi Combined passive stretching and active movement rehabilitation of lower-limb impairments in children with cerebral palsy using a portable robot
    Yi Ning Wu
    Rehabilitation Institute of Chicago, Chicago, IL, USA
    Neurorehabil Neural Repair 25:378-85. 2011
    Ankle impairments are closely associated with functional limitations in children with cerebral palsy (CP). Passive stretching is often used to increase the range of motion (ROM) of the impaired ankle...
  61. ncbi Decreasing incidence and severity of cerebral palsy in prematurely born children
    Ingrid C van Haastert
    Department of Neonatology, Wilhelmina Children s Hospital University Medical Center Utrecht, Utrecht, The Netherlands
    J Pediatr 159:86-91.e1. 2011
    To examine incidence and severity of cerebral palsy (CP), and associated factors among preterm survivors (gestational age <34 weeks), admitted to a neonatal intensive care unit from 1990-2005.
  62. ncbi Hand impairments and their relationship with manual ability in children with cerebral palsy
    Carlyne Arnould
    Laboratory of Rehabilitation and Physical Medicine, Universite Catholique de Louvain, Bruxelles, Belgium
    J Rehabil Med 39:708-14. 2007
    To study hand impairments and their relationship with manual ability in children with cerebral palsy.
  63. ncbi Age-related changes of pain experience in cerebral palsy and healthy individuals
    Inmaculada Riquelme
    Department of Nursing and Physiotherapy, University of the Balearic Islands, Palma de Mallorca, Spain
    Pain Med 12:535-45. 2011
    Pain is a serious problem for many individuals with cerebral palsy (CP). Pain and injury in early life may cause long-term changes in somatosensory and pain processing...
  64. pmc Joint-position sense and kinesthesia in cerebral palsy
    JASON R WINGERT
    Department of Health and Wellness, University of North Carolina at Asheville, Asheville, NC 28804, USA
    Arch Phys Med Rehabil 90:447-53. 2009
    To examine joint-position sense and kinesthesia in all extremities in participants with diplegic or hemiplegic cerebral palsy (CP).
  65. ncbi White matter injury correlates with hypertonia in an animal model of cerebral palsy
    Alexander Drobyshevsky
    Department of Pediatrics, Evanston Northwestern Healthcare and Northwestern University, Evanston, Illinois 60201, USA
    J Cereb Blood Flow Metab 27:270-81. 2007
    Hypertonia and postural deficits are observed in cerebral palsy and similar abnormalities are observed in postnatal rabbits after antenatal hypoxia-ischemia...
  66. ncbi Neonatal and 5-year outcomes after birth at 30-34 weeks of gestation
    Stephane Marret
    Department of Neonatal Medicine, Rouen University Hospital and Inserm Avenir Research Group, Institute for Biomedical Research, University of Rouen, Rouen, France
    Obstet Gynecol 110:72-80. 2007
    ..To evaluate the rates of in-hospital death, neonatal complications, and 5-year outcomes of infants born at 30-34 weeks of gestation...
  67. ncbi Repeat injection of botulinum toxin A is safe and effective for upper limb movement and function in children with cerebral palsy
    Kevin Lowe
    Department of Paediatric Rehabilitation, Sydney Children s Hospital and University of New South Wales, Randwick, Australia
    Dev Med Child Neurol 49:823-9. 2007
    ..Forty-two children (31 males, 11 females; range 2-8 y, mean 4 y [SD 1 y 7 mo]) with hemiplegic cerebral palsy (Gross Motor Function Classification System Level I) longitudinally participated for 30 months, with the first ..
  68. ncbi Quantitative aspects of the early motor repertoire in preterm infants: do they predict minor neurological dysfunction at school age?
    Janneke L M Bruggink
    Department of Pediatrics, Division of Neonatology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, The Netherlands
    Early Hum Dev 85:25-36. 2009
    ..Qualitative aspects of the motor repertoire, at 11-16 weeks post-term are predictive for minor neurological dysfunction (MND) at 7 to 11 years of age. Predictive value of quantitative aspects is unknown so far...
  69. ncbi Adverse events and health status following botulinum toxin type A injections in children with cerebral palsy
    Stephen J O'Flaherty
    Kids Rehab, The Children s Hospital at Westmead, Westmead, NSW, Australia
    Dev Med Child Neurol 53:125-30. 2011
    The aim of this study was to assess changes in health status before and after, as well as adverse events after, botulinum toxin type A (BoNT-A) injections in children with cerebral palsy (CP).
  70. ncbi In-home virtual reality videogame telerehabilitation in adolescents with hemiplegic cerebral palsy
    Meredith R Golomb
    Division of Pediatric Neurology, Indiana University School of Medicine, Indianapolis, IN, USA
    Arch Phys Med Rehabil 91:1-8.e1. 2010
    Golomb MR, McDonald BC, Warden SJ, Yonkman J, Saykin AJ, Shirley B, Huber M, Rabin B, AbdelBaky M, Nwosu ME, Barkat-Masih M, Burdea GC. In-home virtual reality videogame telerehabilitation in adolescents with hemiplegic cerebral palsy.
  71. pmc The relationship between fractures and DXA measures of BMD in the distal femur of children and adolescents with cerebral palsy or muscular dystrophy
    Richard C Henderson
    Department of Orthopaedics, University of North Carolina, Chapel Hill, NC 27599 7055, USA
    J Bone Miner Res 25:520-6. 2010
    ..in a cross-sectional study of 619 children aged 6 to 18 years with muscular dystrophy or moderate to severe cerebral palsy compiled from eight centers...
  72. ncbi Management of the upper limb in cerebral palsy
    Terence Y P Chin
    Department of Orthopaedics, Royal Children s Hospital, Parkville, Victoria, Australia
    J Pediatr Orthop B 14:389-404. 2005
    The management of the upper limb in cerebral palsy is often complex and challenging...
  73. ncbi Amplitude-integrated EEG is useful in predicting neurodevelopmental outcome in full-term infants with hypoxic-ischemic encephalopathy: a meta-analysis
    R Edwin Spitzmiller
    Department of Pediatrics, Division of Neonatology, University of Cincinnati and the Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    J Child Neurol 22:1069-78. 2007
    ..is a common cause of neurological complications resulting in chronic handicapping conditions, such as cerebral palsy. Amplitude-integrated electroencephalography (EEG) has been used in many European countries for more than a ..
  74. ncbi Effectiveness of botulinum toxin A for upper and lower limb spasticity in children with cerebral palsy: a summary of evidence
    Marissa Barlaan Lukban
    Department of Pediatrics and Neurosciences, University of the Philippines College of Medicine, Manila, Philippines
    J Neural Transm 116:319-31. 2009
    Botulinum toxin type A (BoNT-A) therapy has gained wide acceptance in the management of spasticity in cerebral palsy (CP)...
  75. ncbi Cross-cultural adaptation of the Gross Motor Function Classification System into Brazilian-Portuguese (GMFCS)
    Erika Hiratuka
    Department of Occupational Therapy, Universidade Federal de Sao Carlos UFSCar, Sao Carlos, SP, Brasil
    Rev Bras Fisioter 14:537-44. 2010
    Due to the complexity of clinical symptoms of cerebral palsy and the difficulties in classifying it based upon the motor types and the topography of the body distribution only, Canadian researchers have proposed the Gross Motor Function ..
  76. ncbi Intra- and interrater reliabilities of the Myotonometer when assessing the spastic condition of children with cerebral palsy
    Desiree D Aarrestad
    Physical Therapy Department, University of Montana, Missoula, MT 59812, USA
    J Child Neurol 19:894-901. 2004
    ..a portable electronic device that quantifies muscle tone (stiffness) and paresis, in assessing children with cerebral palsy. Two raters used the Myotonometer to assess the biceps brachii and medial gastrocnemius muscles of 10 children ..
  77. ncbi Investigation of the timed 'up & go' test in children
    Elizabeth N Williams
    School of Physiotherapy, University of Melbourne, Parkville, Victoria 3010, Australia
    Dev Med Child Neurol 47:518-24. 2005
    ..females; mean age 5y 9mo [SD 1y 8mo]; range 3 to 9y) and in 41 young people with physical disabilities due to cerebral palsy or spina bifida (20 males, 21 females; mean age 8y 11mo [SD 4y 3mo], range 3 to 19y)...
  78. ncbi Deficits in eccentric versus concentric torque in children with spastic cerebral palsy
    D L Damiano
    Department of Orthopaedics, University of Virginia, Charlottesville, USA
    Med Sci Sports Exerc 33:117-22. 2001
    The purposes of this study were to determine whether ambulatory children with spastic cerebral palsy (CP) had abnormal isokinetic eccentric peak torque values at the knee and ankle, and to gain further insights on the influence of ..
  79. ncbi Quantitative diffusion tensor tractography of the motor and sensory tract in children with cerebral palsy
    Shoko Yoshida
    Department of Radiology, Kyoto City Hospital, Kyoto, Japan Department of Pediatrics, Kyoto City Hospital, Kyoto, Japan
    Dev Med Child Neurol 52:935-40. 2010
    ..the findings of quantitative diffusion tensor tractography of the motor and sensory tracts in children with cerebral palsy (CP) and typically developed comparison individuals, and also to evaluate the correlation with gross motor ..
  80. ncbi Gross Motor Function Classification System and outcome tools for assessing ambulatory cerebral palsy: a multicenter study
    D J Oeffinger
    Shriners Hospitals for Children, Lexington, KY, USA
    Dev Med Child Neurol 46:311-9. 2004
    The relationships between different levels of severity of ambulatory cerebral palsy, defined by the Gross Motor Function Classification System (GMFCS), and several pediatric outcome instruments were examined...
  81. ncbi Evaluation of a collaborative wheelchair system in cerebral palsy and traumatic brain injury users
    Qiang Zeng
    National University of Singapore
    Neurorehabil Neural Repair 23:494-504. 2009
    ..This article describes the evaluation of the Collaborative Wheelchair Assistant (CWA), a robotic wheelchair that lets the user control the speed and provides guiding assistance along virtual paths programmed in software...
  82. ncbi Stability and harmony of gait in children with cerebral palsy
    Marco Iosa
    Clinical Laboratory of Experimental Neurorehabilitation, Fondazione Santa Lucia IRCCS, Rome, Italy
    Res Dev Disabil 33:129-35. 2012
    The aim of this study was to quantitatively assess the stability and harmony of gait in children with cerebral palsy. Seventeen children with spastic hemiplegia due to cerebral palsy (5.0±2...
  83. ncbi Botulinum neurotoxin A: an unusual systemic effect
    Katherine Howell
    Department of Child Development and Rehabilitation, Royal Children s Hospital, Parkville, Victoria, Australia
    J Paediatr Child Health 43:499-501. 2007
    ..We report the case of a boy with severe cerebral palsy who developed deterioration in respiratory and oromotor function following repeated injections of Botulinum ..
  84. pmc Hamstring contractures in children with spastic cerebral palsy result from a stiffer extracellular matrix and increased in vivo sarcomere length
    Lucas R Smith
    Departments of Bioengineering, University of California, San Diego, CA, USA
    J Physiol 589:2625-39. 2011
    b>Cerebral palsy (CP) results from an upper motoneuron (UMN)lesion in the developing brain. Secondary to the UMNl esion,which causes spasticity, is a pathological response by muscle - namely, contracture...
  85. pmc Sensory and motor deficits in children with cerebral palsy born preterm correlate with diffusion tensor imaging abnormalities in thalamocortical pathways
    Alexander H Hoon
    Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Dev Med Child Neurol 51:697-704. 2009
    b>Cerebral palsy (CP) is frequently linked to white matter injury in children born preterm. Diffusion tensor imaging (DTI) is a powerful technique providing precise identification of white matter microstructure...
  86. ncbi Cerebral palsy rates by birth weight, gestation and severity in North of England, 1991-2000 singleton births
    Svetlana V Glinianaia
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    Arch Dis Child 96:180-5. 2011
    To investigate changes in rates of cerebral palsy (CP) by birth weight, gestational age, severity of disability, clinical subtype and maternal age in the North of England, 1991-2000.
  87. ncbi Prevalence of motor-skill impairment in preterm children who do not develop cerebral palsy: a systematic review
    Jacqueline Williams
    Murdoch Childrens Research Institute, Melbourne, Australia
    Dev Med Child Neurol 52:232-7. 2010
    Motor skill impairment is a common negative outcome in children born preterm who do not develop cerebral palsy (CP)...
  88. ncbi Repeat botulinum toxin-A injections in the upper limb of children with hemiplegia: a randomized controlled trial
    Christine A Olesch
    Developmental Medicine, Royal Children s Hospital, Melbourne, Victoria, Australia
    Dev Med Child Neurol 52:79-86. 2010
    ..of repeat botulinum toxin A (BoNT-A) injections in the affected arm of 22 children with hemiplegic cerebral palsy (19 males, three females), aged 1 year 10 months to 4 years 10 months (mean 3y 8mo, SD 9mo) in a randomized ..
  89. ncbi A systematic review of the clinimetric properties of neuromotor assessments for preterm infants during the first year of life
    Alicia J Spittle
    Victorian Infant Brain Studies, Murdoch Childrens Research Institute, Parkville, Melbourne, Australia
    Dev Med Child Neurol 50:254-66. 2008
    ..85). Selection of motor assessment tools during the first year of life for infants born preterm will depend on the intended purpose of their use for discrimination, prediction, and/or evaluation...
  90. ncbi The health and well-being of caregivers of children with cerebral palsy
    Parminder Raina
    Department of Clinical Epidemiology and Biostatistics, McMaster Evidence based Practice Centre, Hamilton, ON, Canada
    Pediatrics 115:e626-36. 2005
    ..Although impaired motor function is the hallmark of the cerebral palsy (CP) syndromes, many children with this development disorder also experience sensory, communicative, and ..
  91. ncbi A model of cerebral palsy from fetal hypoxia-ischemia
    Matthew Derrick
    Department of Pediatrics, Northwestern University and Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    Stroke 38:731-5. 2007
    ..Prenatal hypoxia-ischemia is believed to account for a majority of cerebral palsy cases...
  92. ncbi High familial risks for cerebral palsy implicate partial heritable aetiology
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany
    Paediatr Perinat Epidemiol 21:235-41. 2007
    b>Cerebral palsy is the commonest cause of severe childhood disability, the aetiology of which is largely unknown. Data on familial aggregation of cerebral palsy are very limited...
  93. pmc Update on stem cell therapy for cerebral palsy
    James E Carroll
    Medical College of Georgia, Neurology, Augusta, GA 30912, USA
    Expert Opin Biol Ther 11:463-71. 2011
    Due to the publicity about stem cell transplantation for the treatment of cerebral palsy, many families seek information on treatment, and many travel overseas for cell transplantation...
  94. ncbi Preterm fetal hypoxia-ischemia causes hypertonia and motor deficits in the neonatal rabbit: a model for human cerebral palsy?
    Matthew Derrick
    Department of Pediatrics, Northwestern University, and Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    J Neurosci 24:24-34. 2004
    ..brain has been strongly implicated in the subsequent development of the hypertonic motor deficits of cerebral palsy (CP) in premature and full-term infants who present with neonatal encephalopathy...
  95. ncbi Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis
    Susan R Hintz
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, 750 Welch Rd, Suite 315, Palo Alto, CA 94304, USA
    Pediatrics 115:696-703. 2005
    ..The objective of this study was to compare growth, neurologic, and cognitive outcomes among ELBW survivors of SurgNEC and MedNEC with NoNEC at 18 to 22 months' corrected age...
  96. ncbi Defining the pathogenesis and pathophysiology of neonatal encephalopathy and cerebral palsy
    Gary D V Hankins
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas 77555 0587, USA
    Obstet Gynecol 102:628-36. 2003
    The topics of neonatal encephalopathy and cerebral palsy, as well as hypoxic-ischemic encephalopathy, are of paramount importance to anyone who ventures to deliver infants...
  97. ncbi Cerebral palsy is characterized by protein mediators in cord serum
    Tuula Kaukola
    Department of Pediatrics and Biocenter Oulu, University of Oulu, Oulu, Finland
    Ann Neurol 55:186-94. 2004
    b>Cerebral palsy (CP) is a major neurodevelopmental disability in childhood. An association between intrauterine infection and CP has been reported...
  98. ncbi Chorioamnionitis and cerebral palsy: a meta-analysis
    Jobe G Shatrov
    School of Medicine, Sydney, The University of Notre Dame Australia and Cerebral Palsy Institute, Darlinghurst, New South Wales, Australia
    Obstet Gynecol 116:387-92. 2010
    To examine the relationships between clinical or histological chorioamnionitis and cerebral palsy using a meta-analysis approach.
  99. ncbi Physical and sedentary activity in adolescents with cerebral palsy
    Carol A Maher
    University of South Australia, Adelaide, SA, Australia
    Dev Med Child Neurol 49:450-7. 2007
    ..This study investigated the physical and sedentary activity patterns of adolescents with cerebral palsy (CP)...
  100. ncbi The effectiveness of passive stretching in children with cerebral palsy
    Tamis Pin
    University of Melbourne, Victoria, Australia
    Dev Med Child Neurol 48:855-62. 2006
    ..this review was to evaluate the evidence on the effectiveness of passive stretching in children with spastic cerebral palsy. Seven studies were selected according to the selection criteria and scored against the Physiotherapy Evidence ..
  101. pmc Practice parameter: pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child
    M R Delgado
    University of Texas Southwestern Medical Center, Dallas, USA
    Neurology 74:336-43. 2010
    To evaluate published evidence of efficacy and safety of pharmacologic treatments for childhood spasticity due to cerebral palsy.

Research Grants77

  1. Hybrid Optical/Doppler Imaging of Ischemia in NEC - a multicenter trial
    David A Benaron; Fiscal Year: 2010
    ..NEC requiring surgery carries increased risk of cerebral palsy, cognitive or psychomotor impairment, or both...
  2. Secondary Muscle Pathology &Metabolic Dysregulation in Adult with Cerebral Palsy
    Mark Peterson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Premature declines in function among adults with cerebral palsy (CP) may occur as a result of early and accelerated weakness, beyond that which is expected for adults in the general population...
  3. EEG Synchrony, perinatal risk and outcome: analysis of CHIME data
    PHILIP GEORGE GRIEVE; Fiscal Year: 2010
    ..care have led to decreased mortality of premature infants;however, these infants remain at high risk for cerebral palsy (CP), developmental delay, and sensory-motor deficits in infancy and learning disabilities, dyslexia, and ..
  4. Biochemical, Biomechanical & Morphological Properties of Quantitative Ultrasound
    Barbara L McFarlin; Fiscal Year: 2010
    ..1% to 0.4%;cerebral palsy could be reduced from 6.3% to 0.7%;and respiratory distress syndrome could be decreased from 44% to 3%...
  5. DAMP-RAGE Signaling and Fetal Injury in Inflammation-Induced Preterm Birth
    Irina A Buhimschi; Fiscal Year: 2013
    ..intra-uterine and/or fetal inflammation, prematurity and incidence of adverse neonatal outcomes, including cerebral palsy. If targeted interventions to improve outcome are to be developed we need to fully understand the molecular ..
  6. Chondroitin Sulfate Proteoglycan and Myelination in Intraventricular Hemorrhage
    Praveen Ballabh; Fiscal Year: 2010
    ..Intraventricular hemorrhage (IVH) in premature infants predisposes to white matter injury and subsequent cerebral palsy. The most common white matter injury in premature infants is 'gliosis and hypomyelination with intact ..
  7. Mother Sibling Interactions
    Julie A Thompson; Fiscal Year: 2010
    ..Many VLBW infants experience some degree of cognitive, motor, and language delays, [4-7] and 5-10% develop cerebral palsy.[8, 9] Parents look forward to the discharge of a VLBW from the hospital, but at the same time they are ..
  8. Early Identification of Developmental Disorders in Infants
    B Eugene Parker; Fiscal Year: 2012
    ..g., cerebral palsy, mental retardation) and an additional 25-50% exhibiting mild to moderate neurodevelopmental disabilities (e.g...
  9. Effect of botulinum toxin plus vibration on bone in children with cerebral palsy
    Christopher M Modlesky; Fiscal Year: 2012
    ..This may pose a significant problem for children with spastic cerebral palsy (CP) because they are often treated with Botox and they already feature low bone mass and underdeveloped bone ..
  10. PROTECTIVE EFFECTS OF DELAYED CORD CLAMPING IN VLBW INFANTS
    JUDITH SMITH MERCER; Fiscal Year: 2012
    ..Of the approximately 57,000 infants born annually at less than 1500 grams, 10% develop cerebral palsy and 25 to 50% show later cognitive and behavioral deficits affecting school performance with higher rates ..
  11. Translational refinement of adaptive communication system for locked-in patients
    Melanie Fried-Oken; Fiscal Year: 2013
    ..stroke, Parkinson's disease, multiple sclerosis, spinal cord injury) and neurodevelopmental disorders (cerebral palsy, muscular dystrophy) drive the proposed research...
  12. Physiological Disturbances Associated with Neonatal Intraventricular Hemorrhage
    JEFFREY RADIN KAISER; Fiscal Year: 2012
    ..Approximately 75% of these infants develop mental retardation and/or cerebral palsy, resulting in profound individual and familial consequences...
  13. Mitochondria, Superoxide &MnSOD in a fetal hypoxic cerebral palsy model
    Matthew Derrick; Fiscal Year: 2012
    Hypoxic-ischemic brain injury to fetuses results in stillbirths, neonatal death, cerebral palsy, mental retardation or learning disabilities...
  14. Joubert Syndrome Biennial Conference: Advancing Translational Ciliopathy Research
    DANIEL A DOHERTY; Fiscal Year: 2013
    ..Joubert syndrome and related disorders (JSRD) provide a model for studying intellectual disability, ataxic cerebral palsy, retinal dystrophy, cystic kidney disease, and liver fibrosis...
  15. Sensorimotor Control of the Human Orofacial System
    Steven M Barlow; Fiscal Year: 2012
    ..Prematurity is the leading cause of developmental disabilities in children, including cerebral palsy, mental retardation, blindness, chronic lung problems, attention deficit, and speech/language disorders...
  16. Detection and Quantification of Neonatal Intraventricular Hemorrhage
    Michael D Weiss; Fiscal Year: 2013
    ..Large IVHs are associated with unfavorable neurologic outcomes. Adverse neurodevelopmental sequelae include cerebral palsy, seizures, posthemorrhagic hydrocephalus (which may require a ventriculoperitoneal shunt), blindness, deafness,..
  17. Cytokines and the blood-brain barrier in the ovine fetus
    Barbara S Stonestreet; Fiscal Year: 2012
    ..Perinatal hypoxic/ischemic brain injury often results in cerebral palsy (CP) and mental retardation...
  18. Glial Interactions in Premyelinating Oligodendrocyte Destruction
    Jianrong Li; Fiscal Year: 2010
    ..provided by applicant): Periventricular leukomalacia (PVL) is the principal white matter lesion underlying cerebral palsy and a leading cause of chronic neurological deficits in survivors of premature birth...
  19. Fetal Brain Damage: A Placental Disorder
    ANNA PENN; Fiscal Year: 2009
    ..provide fundamental new insights in placental physiology and neurodevelopment, help redefine disorders such as cerebral palsy, autism and schizophrenia as disorders of the placenta and open new avenues to theraputic treatments to ..
  20. Viral Immunomodulation and Rational CMV Vaccine Design
    Mark R Schleiss; Fiscal Year: 2013
    ..newborn infants from the devastating consequences of congenital HCMV infection, including mental retardation, cerebral palsy, and deafness...
  21. PPM-PREP: Peer-Mentored Preparedness for Adults with Developmental Disabilities
    DAVID PAUL EISENMAN; Fiscal Year: 2010
    ..intervention targeting adults with a developmental disability, such as mental retardation, epilepsy, cerebral palsy or autism, who are living independently in the community (ADD)...
  22. UNDERSTANDING NEUROBEHAVIORAL DEFICITS IN PRETERM INFANTS THROUGH IMAGING
    David C Van Essen; Fiscal Year: 2012
    ..Approximately 10-15% of very preterm children (born <30 weeks gestational age) develop cerebral palsy, and 30 - 60% of very preterm children experience cognitive impairments...
  23. Glial Interactions in Premyelinating Oligodendrocyte Destruction
    Jianrong Li; Fiscal Year: 2012
    ..Human periventricular leukomalacia (PVL) is the major form of cerebral white matter injury underlying cerebral palsy and a leading cause of chronic neurological deficits in survivors of premature birth...
  24. Periventricular White Matter Injury Prevention
    Scott A Rivkees; Fiscal Year: 2013
    ..associated with significant morbidity, as affected individuals may have profound intellectual impairment and cerebral palsy 5-7...
  25. Hands-Free Assistive Reading Technology for Persons with Disabilities
    IRENE SANDRA SCHIPPER; Fiscal Year: 2010
    ..cerebrovascular accidents, spinal cord injuries, amyotrophic lateral sclerosis (ALS), multiple sclerosis, cerebral palsy, and arthritic joint changes...
  26. Molecular Characterization of Neural Stem Cell Apoptosis
    KEVIN AARON ROTH; Fiscal Year: 2012
    ..in hypoxia-ischemia-induced neural stem cell death in the neonatal mouse brain in vivo, a model of human cerebral palsy, and test the hypothesis that p53 regulates neural stem cell death, at least in part, through a transcription-..
  27. Design of Slack Channel Activators
    Heike Wulff; Fiscal Year: 2012
    ..treatment of stroke and the prevention of the effects of global cerebral ischemia as occurs, for example, in cerebral palsy. By increasing the slow afterhyperpolarizations, KNa channel activators may also be useful for reducing ..
  28. A Multimodality Approach to Estimating Newborn Brain Oxygen Metabolism (CMRO2)
    PATRICIA ELLEN GRANT; Fiscal Year: 2010
    ..It is a common cause of cerebral palsy, seizures, complex behavioral disorders and intellectual impairment...
  29. Determining Prevalence of Acute Bilirubin Encephalopathy in Developing Countries
    Tina Marye Slusher; Fiscal Year: 2013
    ..Data from large referral hospitals strongly suggests that ABE is a major cause of neurologic disability (cerebral palsy, deafness, language difficulty) and death in neonates in developing countries...
  30. Long term consequences of white matter damage by perinatal hyperoxia.
    Vittorio Gallo; Fiscal Year: 2013
    ..by perinatal hyperoxia PI: Vittorio Gallo, PhD PROJECT SUMMARY Survivors of premature birth frequently develop cerebral palsy and cognitive impairment...
  31. Cellular and molecular mechanisms of preterm white matter injury
    Art Riddle; Fiscal Year: 2013
    ..clinical problem that results in deleterious consequences for motor and cognitive development resulting in cerebral palsy and related learning disabilities by largely unknown pathogenic mechanisms...
  32. Chronic intermittent hyperoxia and development of respiratory control
    Ryan W Bavis; Fiscal Year: 2013
    ..hyperoxia may contribute to pathologies such as bronchopulmonary dysplasia, retinopathy of prematurity, and cerebral palsy. Despite these efforts, infants routinely experience episodes of hyperoxia during O2 therapy...
  33. Cortical Control of Hindlimb Muscles in Primates
    PAUL DAVID CHENEY; Fiscal Year: 2012
    ..relate directly to normal movement as well as aspects of movement disorders in conditions such as stroke and cerebral palsy. While the cortical control of the arm and hand in primates has been the focus of considerable attention over ..
  34. Late adverse Impact of Getting Hyperbilrubinemia or photo Therapy (LIGHT) study
    Thomas B Newman; Fiscal Year: 2013
    ..of jaundice in newborns: 1) it is not known to what extent high bilirubin levels increase the risks of cerebral palsy and hearing loss, the two main adverse effects of hyperbilirubinemia;and 2) it is not known whether ..
  35. Conjunctival Continuous Blood and Tissue Gas Monitor for Infant Care
    LOTHAR KEMPEN; Fiscal Year: 2009
    ..If the oxygen is insufficient, the infant may develop cerebral palsy or expire, while too much oxygen may cause blindness from retinopathy...
  36. Identification of maternal and fetal genetic factors in preterm birth
    Jeffrey C Murray; Fiscal Year: 2010
    ..Surviving infants have high rates of cognitive delay, cerebral palsy, chronic lung disease, blindness and deafness...
  37. Motion-Specific Toy Controllers for Upper Extremity Rehabilitation in Children
    Joseph J Crisco; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cerebral palsy (CP) is a neuromotor impairment comprised of a group of non-progressive clinical syndromes of children that are characterized by motor dysfunction and affects approximately one out of ..
  38. Portion control lifestyle change to decrease obesity in persons with disabilities
    Mary E Segal; Fiscal Year: 2012
    ..This proposal results from the collaboration of a community agency, United Cerebral Palsy of Central Pennsylvania, and an academic center, Temple University, funded through NIH's "Partners in ..
  39. Effects of Methylmercury on Neuronal Cell Migration
    Hitoshi Komuro; Fiscal Year: 2010
    ..The victims manifested a cerebral palsy-like syndrome characterized by severe mental retardation, motor dysfunction, and repeated convulsions...
  40. Human Epilepsy Genetics - Neuronal Migration Disorders
    Christopher A Walsh; Fiscal Year: 2013
    ..It is known that epilepsy, specific learning deficits and mental retardation, cerebral palsy, and abnormalities of brain volume can be attributed in many cases to pathological malformations of the ..
  41. Point-of Care System for Determination of Bilirubin Capacity in Neonates
    GLEN D RAMSAY; Fiscal Year: 2013
    ..jaundice) in neonates has long been known to lead to neurological dysfunction including irreversible athetoid cerebral palsy with speech, ocular and hearing impairments, and even death...
  42. CELL IDENTITY DETERMINATION IN CEREBRAL CORTEX
    Christopher A Walsh; Fiscal Year: 2013
    ..Abnormalities of cerebral cortical development can cause mental retardation, epilepsy, learning disorders, and cerebral palsy. In the previous funding period of this grant we studied of the mechanisms of several causes of microcephaly (..
  43. Role of Neuronal NOS in Neurotoxicity
    Stephen M Black; Fiscal Year: 2010
    ..The neurologic sequelae of the severe form of this injury include mental retardation, epilepsy, cerebral palsy and blindness...
  44. Gestural Interfaces and Robotics for Rehabilitation
    CORINNA E LATHAN; Fiscal Year: 2010
    ..the clinical efficacy of the CosmoBot Robotics System as a therapy intervention for children diagnosed with cerebral palsy, brain injury, and stroke...
  45. Neurotrophin Protection of Hypoxic Ischemic Brain Injury
    Mir Ahamed Hossain; Fiscal Year: 2013
    ..by applicant): Perinatal hypoxia-ischemia (HI) is a major cause of life-long neurological disability such as cerebral palsy. There are few treatments available for this devastating disorder...
  46. Glutamate Receptors in Hypoxic-ischemic Injury to Developing Oligodendrocytes
    Wenbin Deng; Fiscal Year: 2012
    ..PVL) is the predominant form of brain injury in the premature infant, and the most common cause of cerebral palsy. PVL affects up to 50% of the 56,000 premature infants born in the U. S...
  47. Neonatal Biomarkers in Extremely Preterm Babies Predict Childhood Brain Disorders
    Karl Kuban; Fiscal Year: 2013
    ..11% had cerebral palsy, 40% had a developmental quotient below 70, and 11% had microcephaly...
  48. Structural Mechanisms of Botulinum Neurotoxin Pathogenesis
    DANA BORDEN LACY; Fiscal Year: 2012
    ..power, the potency of botulinum neurotoxin allows it to be used clinically in the treatment of dystonias, cerebral palsy, multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's, and migraines...
  49. Potential use of a decoy peptide for hypoxia/ischemia treatment
    Michel Baudry; Fiscal Year: 2010
    ..rate of children developing serious neurological disorders, including motor and learning disabilities, cerebral palsy and seizures...
  50. Optimizing communication devices for children with dyskinetic cerebral palsy
    Terence D Sanger; Fiscal Year: 2012
    ..For children with dyskinetic cerebral palsy (CP and severe arm movement disorders, devices such as adapted keyboards, programmable touch-screens, and ..
  51. Mechanisms and novel therapy in intrauterine inflammation induced brain injury
    Sujatha Kannan; Fiscal Year: 2013
    ..Maternal immune activation has been implicated in the development of neurodevelopmental disorders such cerebral palsy, but there is a fundamental knowledge gap in understanding the mechanisms by which maternal inflammation ..
  52. Exploring the Effects of Rehabilitation on Brain Remodeling in Progressive MS
    VICTOR WILLIAM MARK; Fiscal Year: 2010
    ..efficacy for significantly improving real-world motor disability in other chronic disorders (stroke and cerebral palsy) in randomized clinical trials...
  53. NEUROBIOLOGY OF CORTICAL SYSTEMS
    MICHAEL CRAIR; Fiscal Year: 2013
    ..such as dyslexia, autism, Tourette's Syndrome, Attention Deficit Hyperactivity Disorder, epilepsy, cerebral palsy, dementias (e.g., Alzheimer's and Huntington's diseases), and stroke...
  54. Molecular Mechanisms of Oligodendrocyte Differentiation and Myelination
    QING R LU; Fiscal Year: 2013
    ..with myelinating diseases such as multiple sclerosis and periventricular leukomalacia - a precursor lesion of cerebral palsy occurred in premature infants...
  55. Selective Inhibition of Neuronal Nitric Oxide Synthase
    Richard B Silverman; Fiscal Year: 2013
    ..At present two of our inhibitors have been found to be very effective at preventing cerebral palsy phenotype in a rabbit model for cerebral palsy. For this indication, administration by injection is acceptable...
  56. Brain Research to Ameliorate Impaired Neurodevelopment-Home-based Intervention
    Waldemar A Carlo; Fiscal Year: 2010
    ..Survivors of birth asphyxia have high rates of mental retardation, cerebral palsy, and other neurodevelopmental disorders...
  57. Influence of human gene variants on the effects of developmental MeHg exposure
    Michael J Carvan; Fiscal Year: 2010
    ..Prenatally exposed children display a range of effects varying from severe cerebral palsy to subtle developmental delays...
  58. White matter injury in germinal matrix hemorrhage
    Praveen Ballabh; Fiscal Year: 2013
    ..premature infants and predisposes them to white matter injury and to the attendant neurologic dysfunctions-- cerebral palsy plus cognitive deficits. The most common white matter injury in these infants is "hypomyelination and gliosis"...
  59. Cerebellar stimulation for the treatment of dystonia: preclinical studies
    Ellen J Hess; Fiscal Year: 2013
    ..abnormal activity of the cerebellum is observed in many different forms of dystonia additionally, some cerebral palsy patients, who also often suffer from dystonia in addition to spasticity, have experienced improvement after ..
  60. Near Infrared Brain Imaging for Guiding Treatment in Children with Cerebral Palsy
    Georgios Alexandrakis; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Near Infrared Brain Imaging for Guiding Treatment in Children with Cerebral Palsy Abstract We propose a feasibility study for the translation of functional near infrared (fNIR) brain imaging as a tool ..
  61. Mechanisms of Neonatal Erythropoietin Neuroprotection
    Shenandoah Robinson; Fiscal Year: 2011
    Children who are born very preterm are prone to cerebral palsy, epilepsy, cognitive delay and behavioral problems, but current interventions have failed to reduce the neurologic morbidity...
  62. NEUROBIOLOGY OF DISEASE IN CHILDREN CONFERENCES
    Bernard L Maria; Fiscal Year: 2013
    ..held from 2006-2009 on spinal muscular atrophy (2006), brain tumors (2007), injury to the preterm brain and cerebral palsy (2008), and muscular dystrophy (2009) were also very successful...
  63. ZeroG: Dynamic Over-Ground Body-Weight Support System
    Joseph Hidler; Fiscal Year: 2009
    ..and endurance while unsupported, are common to individuals following stroke, multiple sclerosis (MS), cerebral palsy (CP), spinal cord injury (SCI), amputation, and normal complications related to general aging...
  64. EEG synchrony of preterm infants: Regional disparities and perinatal risks
    Philip Grieve; Fiscal Year: 2009
    ..low birth weight (ELBW: birth weight <1000gm;age at birth ~ <30 wks) infants are at high risk for cerebral palsy (CP), developmental delay, and sensory-motor deficits in infancy and learning disabilities, dyslexia, and ..
  65. GENETIC ANALYSIS OF PAROXYSMAL DYSTONIC CHOREOATHETOSIS
    John Fink; Fiscal Year: 2000
    ..dystonia, Tourette syndrome, Parkinson's disease, neuroleptic-induced tardive dyskinesia and extrapyramidal cerebral palsy. Moveover, understanding the molecular basis of PDC will suggest mechanisms by which alcohol and caffeine ..
  66. Early Identification of Developmental Disorders in Infants
    B Parker; Fiscal Year: 2007
    ..g., cerebral palsy, mental retardation) and an additional 25-50% exhibiting mild to moderate neurodevelopmental disabilities (e.g...
  67. Dystonia in an Animal Model of Kernicterus
    Steven Shapiro; Fiscal Year: 2007
    ..of dystonia secondary to neonatal hyperbilirubinemia in order to better treat this severe dystonic form of cerebral palsy. Classic kernicterus with dystonia, "athetoid cerebral palsy," oculomotor and auditory impairments, as well as ..
  68. EXPERIMENTAL MODEL FOR CHORIOAMNIONITIS AND PREMATURITY
    Michael Gravett; Fiscal Year: 2005
    ..cause of prematurity, and are associated with increased risk of neonatal white matter lesions of the brain and cerebral palsy. However, the mechanisms by which infection leads to prematurity and/or cerebral palsy remain speculative and ..
  69. IMPROVING GAIT AND FUNCTION IN CP BY STRENGTHENING THE ANKLE
    Jack Engsberg; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Many treatments exist to improve the gait and function of persons with cerebral palsy (CP)...
  70. Placental Pathology: Digital Assessment and Validation
    Carolyn Salafia; Fiscal Year: 2009
    ..greatest single agent of perinatal morbidity and mortality) as well as a contributor to the development of cerebral palsy and other significant childhood diseases...
  71. Applications of FES Artificial Walking for Cerebral Palsy
    Jessica Rose; Fiscal Year: 2009
    ..conference is to create a research network on functional electrical stimulation (FES) assisted walking in cerebral palsy (CP)...
  72. MECHANISMS OF HYPOXIC CEREBRAL VASODILATATION IN NEWBORN
    William Pearce; Fiscal Year: 1992
    ..hypoxic insults, there is a 20 to 30% risk for significant neurological and developmental disorders including cerebral palsy, mental retardation, epilepsy, and intraventricular hemorrhage...
  73. HYPOTHYROXINEMIA OF PREMATURITY AND NEURODEVELOPMENT
    MARY REUSS; Fiscal Year: 1993
    ..In our preliminary analyses, low thyroxine levels at birth are significantly associated with subsequent cerebral palsy and with delay in cognitive development at age 2...
  74. CHORIOAMNIONITIS--CYTOKINES ALTER PERINATAL HEMODYNAMICS
    TOBY YANOWITZ; Fiscal Year: 2003
    ..b>Cerebral palsy is 30 times more common in premature than term infants and may be predicted by periventricular leukomalacia (..
  75. Epo Neuroprotection of ELBW Infants: Planning Grant
    Sandra E Juul; Fiscal Year: 2010
    ..Major morbidities include cerebral palsy, deafness, blindness, and mental retardation, and one or more of these problems is present in up to 48% of ..
  76. OUTCOMES OF HEEL CORD LENGTHENING IN CHILDREN WITH CP
    Jack Engsberg; Fiscal Year: 1999
    ..Adapted from the Applicant's Description): The long term goal is to improve function in children with cerebral palsy (CP). Equinus deformity is the most common problem in children with CP...
  77. Reactive nitrogen species in hypoxic fetal brain injury
    Sidhartha Tan; Fiscal Year: 2007
    Oxygen deficiency in babies results in dire consequences of stillbirths, newborn epilepsy, cerebral palsy, mental retardation and learning difficulties later in life...