post traumatic epilepsy
Summary: Recurrent seizures causally related to CRANIOCEREBRAL TRAUMA. Seizure onset may be immediate but is typically delayed for several days after the injury and may not occur for up to two years. The majority of seizures have a focal onset that correlates clinically with the site of brain injury. Cerebral cortex injuries caused by a penetrating foreign object (CRANIOCEREBRAL TRAUMA, PENETRATING) are more likely than closed head injuries (HEAD INJURIES, CLOSED) to be associated with epilepsy. Concussive convulsions are nonepileptic phenomena that occur immediately after head injury and are characterized by tonic and clonic movements. (From Rev Neurol 1998 Feb;26(150):256-261; Sports Med 1998 Feb;25(2):131-6)
Publications170 found, 100 shown here
- Posttraumatic epilepsyA Rinaldi
Neurol Sci 24:229-30. 2003
- Post traumatic epilepsy: a review of scientific evidenceY K Gupta
Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110 029
Indian J Physiol Pharmacol 50:7-16. 2006b>Post traumatic epilepsy is the development of recurrent seizures following head trauma and has a high clinical relevance. Several risk factors including some genetic factors increase the susceptibility of post traumatic epilepsy...
- [Nonlinear EEG analysis in prognosis of pharmacoresistant therapy and evaluation of using millimeter (MM) therapy in its treatment]G N Avakian
Zh Nevrol Psikhiatr Im S S Korsakova 107:42-5. 2007....
- Suppression of cortical myoclonus by levetiracetamRobert Schauer
Department of Neurology, Hospital Hochzirl, Zirl, Austria
Mov Disord 17:411-5. 2002..Add-on therapy with levetiracetam significantly improved the patient's clinical condition, suppressed cortical myoclonus-associated spikes, and enabled further neurorehabilitation...
- Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsyHiroaki Tani
Department of Neurology, Stanford University Medical Center, Stanford, CA 94305, USA
Neurobiol Dis 25:230-8. 2007....
- Post-traumatic epilepsy in children requiring inpatient rehabilitation following head injuryR E Appleton
The Roald Dahl EEG Unit, Alder Hey Children s Hospital, Liverpool, UK
J Neurol Neurosurg Psychiatry 72:669-72. 2002..To study the prevalence of, and identify possible risk factors for, the development of post-traumatic epilepsy in a cohort of children with severe head injury treated in an inpatient rehabilitation unit...
- Prevention of epilepsy after head trauma: do we need new drugs or a new approach?Larry S Benardo
Department of Neurology, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
Epilepsia 44:27-33. 2003..A pilot study is proposed to begin to translate these findings to explore the feasibility of early VPA delivery to severe head trauma patients admitted to Kings County Hospital Center in Brooklyn, NY, a Level 1 trauma center...
- Progression from frontal-parietal to mesial-temporal epilepsy after fluid percussion injury in the ratRAIMONDO D'AMBROSIO
Department of Neurological Surgery, Center on Human Development and Disability, University of Washington, School of Medicine, Harborview Medical Center, Box 359915, 325 Ninth Avenue, Seattle, WA 98104, USA
Brain 128:174-88. 2005..These observations establish numerous similarities between FPI-induced and human PTE and further validate it as a clinically relevant model of PTE...
- Secretion of natriuretic peptides caused by an epileptic attackT Obi
Department of Neurology, National Shizuoka Hospital, Shizuoka, Japan
Acta Neurol Scand 106:225-8. 2002..To describe clinical features of a patient with secretions of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) during an epileptic attack...
- [The forensic determination of post-traumatic epilepsy in 21 patients]L Liu
Yueyang Intermediate People's Court, Hunan 410200
Fa Yi Xue Za Zhi 17:25-7, 62. 2001..CONCLUSION: The forensic determination of post traumatic epilepsy must be on the basis of traumatic and previous history combined with EEG, CT and MRI analysis.
- Post-traumatic seizure disorder following acquired brain injuryRobert Teasell
Lawson Health Resort Institute, London, Ontario, Canada
Brain Inj 21:201-14. 2007....
- [Clinical features and surgical treatment of posttraumatic epilepsy]Song Tao Qi
Department of Neurosurgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
Di Yi Jun Yi Da Xue Xue Bao 24:472-4. 2004..To study the clinical features of posttraumatic epilepsy and evaluate the surgical procedures for anti-epileptic treatment and their therapeutic effects...
- Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesisIrina Kharatishvili
Epilepsy Research Group, Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, FIN 70211 Kuopio, Finland
Brain 130:3155-68. 2007..These results for the first time demonstrate that quantitative diffusion MRI can serve as a tool to facilitate prediction of increased seizure susceptibility in a clinically relevant model of human PTE...
- [Epileptic seizures caused by psychopharmaceuticals]Karl Otto Nakken
Spesialsykehuset for epilepsi, G F Henriksens vei 23, 1337 Sandvika
Tidsskr Nor Laegeforen 123:1542-4. 2003
- [The neurophysiological analysis of symptomatic post-traumatic epilepsy]S A Kurbanova
Zh Nevrol Psikhiatr Im S S Korsakova 107:50-3. 2007..The EEG study with spectral coherent analysis allows to predict post-traumatic epilepsy and to use a differential approach in prescribing the appropriate anticonvulsive therapy to people after head injury...
- [Dysautonomic seizures in patients admitted to an intensive care unit following severe traumatic brain injury]J F Fernández-Ortega
Unidad de Cuidados Intensivos, Hospital Universitario Carlos Haya, Malaga, Spain
Rev Neurol 39:715-8. 2004..To describe clinical and radiologic features of dysautonomic crisis after severe traumatic brain injury and its influence in the clinical situation six months later...
- Post-traumatic early epilepsy in pediatric age group with emphasis on influential factorsOzkan Ates
Department of Neurosurgery, School of Medicine, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey
Childs Nerv Syst 22:279-84. 2006..An acute posttraumatic epileptic fit, which may induce secondary insults, should be hindered. The aim of the study is to define the risk factors for posttraumatic early epilepsy (PTEE) and the indications for prophylactic therapy...
- Posttraumatic seizures in survivors of torture: manifestations, diagnosis, and treatmentAlejandro Moreno
The Austin Medical Education Programs at Brackenridge Hospital, Austin, Texas 78759, USA
J Immigr Health 6:179-86. 2004..This paper addresses the differential diagnosis of posttraumatic epilepsy in survivors of torture...
- Posttraumatic epilepsy with special emphasis on prophylaxis and preventionC A Pagni
Neurosurgical Clinic University of Torino, Torino, Italy
Acta Neurochir Suppl 93:27-34. 2005..Some of them (phosphate diester of vitamin E and C, melatonin, vanillyl alcohol) may be employed in clinical practice, but up to date there is no controlled study in human beings...
- Clinical trials for prevention of epileptogenesisSusan T Herman
Epilepsy Res 68:35-8. 2006..Issues revolve around selection of subjects, consent for participation, length of follow-up, and selection of an appropriate endpoint. The use of biomarkers are a possible solution in future research...
- Traumatic brain injury rehabilitation: state of the scienceWayne A Gordon
Department of Rehabilitation Medicine, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
Am J Phys Med Rehabil 85:343-82. 2006
- Waking-sleep modulation of paroxysmal activities induced by partial cortical deafferentationDragos A Nita
Laboratory of Neurophysiology, Faculty of Medicine, Laval University, Quebec, Canada G1K 7P4
Cereb Cortex 17:272-83. 2007....
- Adenosine A1 receptor knockout mice develop lethal status epilepticus after experimental traumatic brain injuryPatrick M Kochanek
Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
J Cereb Blood Flow Metab 26:565-75. 2006..05) and SE was restricted to the ko mice (83% incidence). Our data suggest a critical endogenous anticonvulsant action of adenosine at A1 receptors early after experimental TBI...
- [Post traumatic partial seizures]P Carvajal
, Zaragoza, 50009,
Rev Neurol 33:737-9. 2001INTRODUCTION: Post traumatic epilepsy represents 4% of the prevalence of the disorder and is one of the sequelas which is most difficult to prevent. Risk factors have been described to predict the appearance of seizures...
- Effectiveness of cerebral hemispherotomy for improving behavioral disorders associated with intractable post-traumatic seizuresMichiharu Morino
Department of Neurosurgery, Osaka City University Graduate School of Medicine, Japan
Neurol Med Chir (Tokyo) 46:182-5. 2006..These findings suggest that the effects of seizures may be reversible in brain areas connected with, but remote from, the epileptogenic cortex...
- Post-traumatic hyperexcitability is not caused by impaired buffering of extracellular potassiumVijayalakshmi Santhakumar
Department of Anatomy and Neurobiology, University of California, Irvine, California 92697 1280, USA
J Neurosci 23:5865-76. 2003....
- Risk factors for posttraumatic seizures in adultsNancy R Temkin
Department of Neurological Surgery, University of Washington, Seattle, Washington 98104, USA
Epilepsia 44:18-20. 2003..This article looks at factors about the injury or individual that put people at especially high risk of developing posttraumatic seizures...
- High-flux haemodialysis treatment as treatment for carbamazepine intoxicationK H Koh
Kuching Sarawak General Hospital, Sarawak
Med J Malaysia 61:109-11. 2006..Thus, haemodialysis using high-flux membranes is a feasible and effective therapeutic option for carbamazepine intoxication...
- Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisisPaul M Vespa
Department of Neurosurgery, University of California Los Angeles, Los Angeles, CA, USA
Crit Care Med 35:2830-6. 2007..To determine whether nonconvulsive electrographic post-traumatic seizures result in increases in intracranial pressure and microdialysis lactate/pyruvate ratio...
- Does glucocorticoid administration prevent late seizures after head injury?Nathaniel F Watson
Neurology and Sleep Disorders Center, University of Washington, Seattle, Washington 98104 2499, USA
Epilepsia 45:690-4. 2004..Preventing posttraumatic epilepsy has been a difficult challenge. In this study we evaluated the association between glucocorticoid administration after traumatic brain injury (TBI) and posttraumatic seizures...
- Neurophysiologically-based mean-field modelling of tonic cortical activity in post-traumatic stress disorder (PTSD), schizophrenia, first episode schizophrenia and attention deficit hyperactivity disorder (ADHD)Donald L Rowe
School of Physics, University of Sydney, NSW 2006, Australia
J Integr Neurosci 3:453-87. 2004..The model is also found to be sensitive to the effects of medication in the schizophrenia and FESz group, further supporting the validity of the model...
- Episodic coma in a new leukodystrophyAlberto J Espay
Department of Neurology, Section of Pediatric Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Pediatr Neurol 26:139-42. 2002..A detailed review of the literature is presented along with discussion of the potential mechanisms of neurologic deterioration...
- Local cortical hypoperfusion imaged with CT perfusion during postictal Todd's paresisMarlon S Mathews
Department of Neurological Surgery, University of California, Irvine, CA, USA
Neuroradiology 50:397-401. 2008..However, it is unclear whether the pathophysiology of Todd's paralysis is related to alterations in cerebral perfusion. We report CT perfusion findings in a patient presenting with postictal aphasia and right hemiparesis...
- A 5-year study of the outcome of surgically treated depressed skull fracturesSyed A Al-Haddad
Walton Centre for Neurology and Neurosurgery, Liverpool, UK
Ann R Coll Surg Engl 84:196-200. 2002..The aim of our study was, therefore, to examine the factors influencing the surgical outcome of patients with depressed skull fractures...
- Prevention and treatment of post-traumatic epilepsyCarlo Alberto Pagni
Expert Rev Neurother 6:1223-33. 2006..However, currently drug therapy should be instituted only after the first late unprovoked seizure...
- [Post-traumatic epilepsy]P de la Pena
Sección de Epilepsia, Hospital Universitario 12 de Octubre, Madrid, Espana
Rev Neurol 26:256-61. 1998..It has not been shown to be of use in preventing post-traumatic epilepsy. Other treatments, such as antioxidants, calcium antagonist and glutamate inhibitors are still only at an experimental stage...
- Post-traumatic seizures exacerbate histopathological damage after fluid-percussion brain injuryYing hui Bao
Department of Neurological Surgery, Neurotrauma Research Center, and The Miami Project To Cure Paralysis, University of Miami School of Medicine, Miami, Florida, USA
J Neurotrauma 28:35-42. 2011..These findings emphasize the need to control seizures after TBI to limit even further damage to the injured brain...
- Quantitative T2 mapping as a potential marker for the initial assessment of the severity of damage after traumatic brain injury in ratIrina Kharatishvili
Department of Neurobiology, AI Virtanen Institute for Molecular Sciences, Epilepsy Research Laboratory, University of Kuopio, Kuopio, Finland
Exp Neurol 217:154-64. 2009....
- Electroclinical features of a family with simple febrile seizures and temporal lobe epilepsy associated with SCN1A loss-of-function mutationEleonora Colosimo
Institute of Neurology, University Magna Graecia, Catanzaro, Italy
Epilepsia 48:1691-6. 2007..We showed that the mutation is associated with a loss of SCN1A function...
- [Frequency of neurological sequelae secondary to head traumas]E Alva
Rev Neurol 24:1390-2. 1996..The commonest findings are of post-traumatic epilepsy and of unspecified changes in behaviour and learning capacity...
- The difference in seizure incidences between young and adult rats related to lipid peroxidation after intracortical injection of ferric chlorideN Golden
Department of Neurosurgery, Sanglah General Hospital, School of Medicine, Udayana University, Denpasar, Bali, Indonesia
Singapore Med J 51:105-9. 2010..This study examined some of the hypothesised reasons for the difference in the incidence of early post-traumatic seizures between children and adults...
- Traumatic brain injuryJane E Risdall
Surgeon Commander, Royal Navy, UK
Philos Trans R Soc Lond B Biol Sci 366:241-50. 2011....
- Animal models of post-traumatic epilepsyAsla Pitkanen
Epilepsy Research Laboratory, AI Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland
J Neurotrauma 23:241-61. 2006....
- Minozac treatment prevents increased seizure susceptibility in a mouse "two-hit" model of closed skull traumatic brain injury and electroconvulsive shock-induced seizuresMaryAnn Chrzaszcz
Department of Pediatrics, Division of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
J Neurotrauma 27:1283-95. 2010..These data implicate glial activation in the mechanisms of epileptogenesis after TBI, and identify a potential therapeutic approach to attenuate the delayed neurological sequelae of TBI...
- Prognostic factors and outcome of children with severe head injury: an 8-year experienceAntonio Chiaretti
Pediatric Intensive Care Unit, Gemelli Hospital, Largo Gemelli, 00168 Rome, Italy
Childs Nerv Syst 18:129-36. 2002..Our aim was to analyze prognostic factors and their association with outcome among children with severe head injury...
- Spontaneous epileptiform activity in rat neocortex after controlled cortical impact injuryLie Yang
Department of Physiology and Pharmacology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
J Neurotrauma 27:1541-8. 2010....
- Fulminant hepatitis after grand mal seizures: mechanisms and role of liver transplantationPhilippe Ichai
Centre Hepatobiliaire, Assistance Publique Hopitaux de Paris, Universite Paris Sud, Hopital Paul Brousse, Villejuif, France
Hepatology 38:443-51. 2003..The neurological prognosis and overall survival of these patients remains poor...
- Blood-brain barrier breakdown following traumatic brain injury: a possible role in posttraumatic epilepsyOren Tomkins
Departments of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel
Cardiovasc Psychiatry Neurol 2011:765923. 2011..Based on recent animal studies and the colocalization found between the region of disrupted BBB and abnormal EEG activity, we suggest a role for a vascular lesion in the pathogenesis of PTE...
- Post-traumatic seizure susceptibility is attenuated by hypothermia therapyColeen M Atkins
Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Eur J Neurosci 32:1912-20. 2010..These findings demonstrate that reductions in seizure susceptibility after TBI are improved with post-traumatic hypothermia and provide a new therapeutic avenue for the treatment of post-traumatic epilepsy...
- [Morphology changes of ubiquitin-proteasome system in traumatic epilepsy]Peng xiang He
Department of Forensic Medicine, Zhongshan Medical College, Sun Yat Sen University, Guangzhou 510080, China
Fa Yi Xue Za Zhi 26:10-4. 2010To investigate the value of ubiquitin(Ub) and ubiquitin-activating enzymel(UbE1) for the appraisement of post traumatic epilepsy (PTE).
- Cognitive and functional outcomes of terror victims who suffered from traumatic brain injuryIsabella Schwartz
Department of Physical Medicine and Rehabilitation, Hadassah University Hospital, Jerusalem, Israel
Brain Inj 22:255-63. 2008..To describe the outcomes of terror victims suffered from traumatic brain injury (TBI)...
- Adenosine neuromodulation and traumatic brain injuryT A Lusardi
R S Dow Neurobiology Laboratory, Portland OR, USA
Curr Neuropharmacol 7:228-37. 2009....
- Neurological and mental outcome after severe head injury in childhood: a long-term follow-up of 318 childrenM Kieslich
Department of Paediatrics, Paediatric Neurology, Johann Wolfgang Goethe University, Frankfurt Main, Germany
Disabil Rehabil 23:665-9. 2001..Identification of prognostic risk factors in paediatric head injury...
- Effect of vagus nerve stimulation in post-traumatic epilepsy and failed epilepsy surgery : preliminary reportHai Ong Lee
Department of Neurosurgery, Research Institute for Clinical Medicine, Chonbuk National University Medical School Hospital, Jeonju, Korea
J Korean Neurosurg Soc 44:196-8. 2008..In this study, we investigated the efficacy of VNS to patients who had refractory result to epilepsy surgery and patients with post-traumatic epilepsy...
- Profile of post-traumatic epilepsy in Benin City, NigeriaO A Ogunrin
Department of Medicine, University of Benin Teaching Hospital, Benin City, Nigeria
West Afr J Med 29:153-7. 2010b>Post traumatic epilepsy is recurrent chronic seizures occurring after four weeks following brain injury. It commonly occurs after road traffic accidents thus making it a preventable cause of chronic seizures...
- Optimizing therapy of seizures in neurosurgeryRoberto Michelucci
Department of Neurosciences, Bellaria Hospital, Bologna, Italy
Neurology 67:S14-8. 2006..The newly developed AEDs that are devoid of hepatic metabolism, such as levetiracetam and gabapentin, are now recommended because of good results in preliminary studies and because they do not show interactions with anticancer agents...
- Therapeutic approaches to epileptogenesis--hope on the horizonAsla Pitkanen
Epilepsy Research Laboratory, AI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland
Epilepsia 51:2-17. 2010..Furthermore, a novel scheme for defining epileptogenesis-related terms is presented...
- Intractable epilepsy and craniocerebral trauma: analysis of 163 patients with blunt and penetrating head injuries sustained in warHadi Kazemi
Shefa Neuroscience Research Center, Tehran, Iran
Injury 43:2132-5. 2012..Patients with military brain injury carry a high risk of intractable post-traumatic epilepsy decades after their injury, and thus require a long-term medical follow-up...
- Pediatric posttraumatic seizures: epidemiology, putative mechanisms of epileptogenesis and promising investigational progressKimberly D Statler
Division of Critical Care, Department of Pediatrics, The University of Utah School of Medicine, Salt Lake City, Utah 84158 0289, USA
Dev Neurosci 28:354-63. 2006....
- Blocking brain-derived neurotrophic factor inhibits injury-induced hyperexcitability of hippocampal CA3 neuronsRaminder Gill
Department of Pharmacology and Therapeutics, McGill University, Bellini Life Sciences Complex, 3649 Promenade Sir William Osler, Montreal, QC, Canada, H3G 0B1
Eur J Neurosci 38:3554-66. 2013..Therefore, our data suggest that blocking the BDNF-TrkB signaling cascade shortly after injury may be a potential therapeutic target for the treatment of post-traumatic epilepsy. ..
- Functional definition of seizure provides new insight into post-traumatic epileptogenesisRAIMONDO D'AMBROSIO
Department of Neurological Surgery, School of Medicine, University of Washington Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104, USA
Brain 132:2805-21. 2009....
- Treatment of post-traumatic epilepsyChristine Hung
Department of Neurology, Department of Veterans Affairs VA, Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA, 90073, USA
Curr Treat Options Neurol 14:293-306. 2012..The potential and need for rigorous clinical research in PTE continue to be in great demand...
- Anti-epileptogenesis in rodent post-traumatic epilepsy modelsAsla Pitkanen
Department of Neurobiology, Epilepsy Research Laboratory, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
Neurosci Lett 497:163-71. 2011..Also, current understanding of the mechanisms and biomarkers for PTE as well as factors associated with preclinical study designs are discussed. Finally, we summarize the attempts to prevent PTE in experimental models...
- A multimodal imaging approach to the evaluation of post-traumatic epilepsySilvia F Storti
Department of Neurological, Neuropsychological, Morphological and Movement Sciences, Section of Clinical Neurology, University of Verona, Policlinico G B Rossi, P le L A Scuro 10, 37134, Verona, Italy
MAGMA 25:345-60. 2012..By combining noninvasive imaging techniques in a multimodal approach, we sought to investigate pathophysiological mechanisms underlying epileptic activity in seven patients with severe traumatic brain injury...
- Topological basis of epileptogenesis in a model of severe cortical traumaVladislav Volman
Howard Hughes Medical Institute, Computational Neurobiology Laboratory, The Salk Institute for Biological Studies, University of California, Riverside, California, USA
J Neurophysiol 106:1933-42. 2011..Thus in the deafferentation model of post-traumatic epilepsy, a trauma-induced change in functional (rather than anatomical) connectivity might be sufficient for epileptogenesis...
- Are the neurotrophic factors a suitable therapeutic target for the prevention of epileptogenesis?Michele Simonato
Section of Pharmacology, Department of Clinical and Experimental Medicine, Neuroscience Center, University of Ferrara, and National Institute of Neuroscience, Ferrara, Italy
Epilepsia 51:48-51. 2010..These findings are discussed with consideration of the hurdles that will have to be overcome before clinical application...
- PET scan as an aid for the return of a head-injured aviator to flying dutyAlon Grossman
Israeli Air Force Aeromedical Center, Israel
Aviat Space Environ Med 77:1080-2. 2006..PET scan was used as an additional tool for predicting the epileptogenic potential of this finding, thus aiding the decision regarding the return of the aviator to flying duty...
- Traumatic brain injuryJan Stevens
Robert J Dole Veteran s Administration, Spinal Cord Injury Dysfunction and Traumatic Brain Injury Clinic, KS, USA
Kans Nurse 83:3-5. 2008
- Prognostic factors in the persistence of posttraumatic epilepsy after penetrating head injuries sustained in warBehzad Eftekhar
Sina Trauma Research Center, Sina Hospital, Tehran, Iran
J Neurosurg 110:319-26. 2009....
- Functional outcome and health-related quality of life 10 years after moderate-to-severe traumatic brain injuryN Andelic
Department of Physical Medicine and Rehabilitation, Ulleval University Hospital, University of Oslo, Oslo, Norway
Acta Neurol Scand 120:16-23. 2009..To describe the functional outcome and health-related quality of life (HRQL) 10 years after moderate-to-severe traumatic brain injury (TBI)...
- Characteristics and surgical outcomes for medial temporal post-traumatic epilepsyP Hartzfeld
Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan 48202, USA
Br J Neurosurg 22:224-30. 2008..The favourable outcomes obtained following surgery in this group attest to a commonality with other risk factors in the genesis of epilepsy in this location...
- Posttraumatic epilepsy: the challenge of translating discoveries in the laboratory to pathways to a cureMarc A Dichter
Department of Neurology, University of Pennsylvania, Philadelphia 19104, USA
Epilepsia 50:41-5. 2009....
- Corticosteroids and head injuryAmit Agrawal
Clin Neurol Neurosurg 110:421-2. 2008
- Mortality in late post-traumatic seizuresJeffrey Englander
Department of Physical Medicine and Rehabilitation, Santa Clara Valley Medical Center, San Jose, California, USA
J Neurotrauma 26:1471-7. 2009....
- Early seizures and cerebral oedema after trivial head trauma associated with the CACNA1A S218L mutationA H Stam
Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
J Neurol Neurosurg Psychiatry 80:1125-9. 2009....
- Occurrence of epilepsy during the first 10 years after traumatic brain injury acquired in childhood up to the age of 18 years in the south western Swedish population-based seriesI Emanuelson
Institution for Clinical Sciences, Department of Pediatrics, University of Gothenburg, Sweden
Brain Inj 23:612-6. 2009..The risk of seizures is increased after a traumatic brain injury (TBI), but the impact and duration of this increased risk is not well characterized in children...
- Clinical depression, posttraumatic stress disorder, and comorbid depression and posttraumatic stress disorder as risk factors for in-hospital mortality after coronary artery bypass grafting surgeryTam K Dao
University of Houston, Baylor College of Medicine, 2002 Holcombe Blvd, Houston, TX 77030, USA
J Thorac Cardiovasc Surg 140:606-10. 2010....
- Presurgical evaluation in refractory epilepsy secondary to meningitis or encephalitis: bilateral memory deficits often preclude surgeryAntonio Donaire
Hospital Clinic i Provincial Barcelona, Spain
Epileptic Disord 9:127-33. 2007..Good surgical outcome can be expected in selected patients with unilateral MTS and congruent memory deficits...
- The impact of prophylactic treatment on post-traumatic epilepsy after severe traumatic brain injuryR Formisano
Rehabilitation Hospital, I R C C S Santa Lucia Foundation, Rome, Italy
Brain Inj 21:499-504. 2007..To assess the incidence of late post-traumatic epilepsy (PTE) in patients with very severe traumatic brain injury (TBI) who either received or did not receive anti-epileptic prophylactic treatment...
- Severe head injury in early infancy: analysis of causes and possible predictive factors for outcomeElisabetta Marton
Neurosurgery Department, Padova University, Ca Foncello Hospital, 31100 Treviso, Italy
Childs Nerv Syst 23:873-80. 2007..The aim of this study was to analyse the causes and prognostic factors for outcome in severe traumatic brain injuries (TBI) in early infancy...
- Neural circuit mechanisms of post-traumatic epilepsyRobert F Hunt
Epilepsy Research Laboratory, Department of Neurological Surgery, University of California San Francisco, CA, USA
Front Cell Neurosci 7:89. 2013..A better understanding of mechanisms that promote the generation of epileptic activity versus those that promote compensatory brain repair and functional recovery should aid development of successful new therapies for PTE...
- [Preventive and therapeutic attitude in post-traumatic epileptic seizures]J Sancho-Rieger
Servicio de Nuerología, Hospital General Universitario de Valencia, Valencia, Espana
Rev Neurol 35:S39-42. 2002..The most important factors governing the presentation of post traumatic seizures have to do with the seriousness of the injury, the extension of the brain tissue that is affected and the penetrating nature of the brain traumatism...
- Epilepsy at the movies: possession to presidential assassinationSallie Baxendale
Institute of Neurology, UCL, London, UK
Lancet Neurol 2:764-70. 2003....
- School-based interventions for children exposed to violenceRichard Neugebauer
JAMA 290:2541-2; author reply 2542. 2003
- Posttraumatic epilepsy risk factors: one-year prospective study after head injuryF Angeleri
Institute for Nervous Diseases, Neurological Clinic, University of Ancona, Italy
Epilepsia 40:1222-30. 1999....
- Changes of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate receptors in layer V of epileptogenic, chronically isolated rat neocortexV N Kharazia
Department of Neurology and Neurological Sciences, Stanford University, CA 94305, USA
Neuroscience 102:23-34. 2001..A sub-population of layer V neurons remains relatively unaffected, and would presumably be capable of generating fast glutamatergic synaptic potentials necessary for the development of synchronous epileptiform activity...
- Antiepileptic drug prophylaxis in severe traumatic brain injuryNicola Latronico
Neurology 61:1161-2; author reply 1162. 2003
- Early post-traumatic seizures in children with head injuryA Chiaretti
Pediatric Intensive Care Unit, Catholic University of Rome, Italy
Childs Nerv Syst 16:862-6. 2000..Appropriate management of head-trauma patients must include suitable and immediate prophylaxis with anti-epileptic drugs...
- Epidemiology of posttraumatic epilepsy: a critical reviewLauren C Frey
Department of Neurology, University of Colorado Health Science Center, Denver, Colorado 80262, USA
Epilepsia 44:11-7. 2003..Traumatic brain injury (TBI) is a major cause of epilepsy. We need to understand its frequency and its contribution to the total spectrum of the convulsive disorders...
- Evaluation and treatment of psychosis after traumatic brain injuryThomas W McAllister
Dartmouth Medical School, Department of Psychiatry, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
NeuroRehabilitation 17:357-68. 2002..Anticonvulsant, antidepressant or other drugs may also be needed in some cases. Medication approaches must be adjusted for the particular characteristics and vulnerabilities of the patient with a TBI...
- Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 19. The role of anti-seizure prophylaxis following severe pediatric traumatic brain injuryP David Adelson
University of Pittsburgh Children s Hospital, USA
Pediatr Crit Care Med 4:S72-5. 2003
- Epilepsy and traumaDavid Ranson
Victorian Institute of Forensic Medicine, Department of Forensic Medicine, Monash University
J Law Med 10:265-6. 2003
- Evaluation of seizure-like episodes in survivors of moderate and severe traumatic brain injuryAnne M Hudak
Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, 75390, USA
J Head Trauma Rehabil 19:290-5. 2004..However, as such therapy is frequently ineffective, we studied the usefulness of prolonged video electroencephalogram (VEEG) monitoring in the clinical management of paroxysmal behaviors in TBI survivors...
- Differential effects of topiramate in patients with traumatic brain injury and obesity--a case seriesOrnah T Dolberg
Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
Psychopharmacology (Berl) 179:838-45. 2005..Topiramate is an antiepileptic drug known to have effects on weight. In order to use this as a tool to treat eating disorders, it is useful to examine whether these effects can be predicted in certain patients...
- Valproic acid-associated sialadenosis of the parotid and submandibular glands: diagnostic and therapeutic aspectsP S Mauz
Department of ENT, University Hospital Tubingen, Tubingen, Germany
Acta Otolaryngol 125:386-91. 2005..If the submandibular glands are involved, partial removal is recommended...
- Valproic acid-induced hyperammonemia: a case reportMariposa McCall
Department of Psychiatry and Behavioral Sciences, University of California, Davis Medical Center, Sacramento, CA 95817, USA
J Clin Psychopharmacol 24:521-6. 2004....
- Effect of melatonin and phenytoin on an intracortical ferric chloride model of posttraumatic seizures in ratsA K Srivastava
Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India
Methods Find Exp Clin Pharmacol 24:145-9. 2002..These findings showed a superior protective effect of melatonin over phenytoin in an intracortical FeCl3 model of posttraumatic epilepsy...
- Diffusion tensor imaging in late posttraumatic epilepsyRakesh K Gupta
Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Epilepsia 46:1465-71. 2005....
- Post-traumatic epilepsy: an overviewAmit Agrawal
Department of Neurosurgery, K S Hegde Medical Academy, Deralakatte, 575018 Mangalore, Karnataka, India
Clin Neurol Neurosurg 108:433-9. 2006..Routine preventive anticonvulsants are not indicated for patients with head injuries, and treatment in the acute phase does not reduce death or disability rates...
- Complications of missile craniocerebral injuries during the Croatian Homeland WarMario Tudor
Department of Neurosurgery, Clinical Hospital Split, Vjekoslava Spinéića 1, 21000 Split, Croatia
Mil Med 170:422-6. 2005..A total of 176 patients with well-defined head injuries from missiles, sustained during the Croatian Homeland War (1991-1995), developed a total of 61 (34.5%) complications...
- School-based interventions for children exposed to violenceNancy Rappaport
JAMA 290:2541; author reply 2542. 2003
- Persisting Grand Mal and Myoclonic Seizures in JME including VeteransAntonio V Delgado-Escueta; Fiscal Year: 2013..Understanding JME disease mechanisms brings an era of targeted and designer medicine, and positively impacts the mission of the VA healthcare system and the health of Veterans. ..
- TBI epileptogenesis: pathologic hippocampal L-glut synaptic plasticityJohn T Slevin; Fiscal Year: 2011....
- Group I Metabotropic Glutamate Receptors and EpileptogenesisPaul A Rutecki; Fiscal Year: 2013....
- TGF-beta Mediated Inflammatory Signaling: a Critical Role in EpileptogenesisDaniela Kaufer; Fiscal Year: 2012..Since brain insults are one of the primary causes of disability with no means of prevention as of yet, this proposal represents an important advancement toward resolving this unmet medical need. ..
- IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUSJEROME NONE ENGEL; Fiscal Year: 2013..The ultimate goal of this research direction is to identify targets for intervention that will treat, prevent, or cure epilepsy, and to define reliable biomarkers of epilepsy. ..
- Chronic TBI Bcl 2-20:34 Protection Against Lowered Seizure SusceptibilityRoi Ann Wallis; Fiscal Year: 2013..To this end, we will also evaluate mitochondrial structure and function after CCI with and without treatment with the Bcl-220-34 peptide. ..
- PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURYIvan Soltesz; Fiscal Year: 2013..It is anticipated that defining the functional consequences of experimental post-traumatic epilepsy will aid in the future development of novel treatment strategies. ..
- PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURYIvan Soltesz; Fiscal Year: 2001....
- Pilot: Levetiracetam to Prevent Post-Traumatic EpilepsyPavel Klein; Fiscal Year: 2006..A positive finding of such a study would be the first successful attempt at prevention of epilepsy, a lifelong debilitating illness. ..
- Developing a rat model of posttraumatic epilepsyPHILIP SCHWARTZKROIN; Fiscal Year: 2005..In addition, animals will be tested for seizure threshold (latency to flurothyl-induced seizures). Treated and tested animals will be sacrificed for histological analysis of damage. ..
- BIOCHEMISTRY OF KINDLING DEVELOPMENTJames McNamara; Fiscal Year: 2000..Fundamental insights emerging from this work may also shed light on signal transduction in a diversity of physiologic and pathologic settings. ..
- CORTICAL EXCITABILITY AFTER TRAUMATIC BRAIN INJURYGolijeh Golarai; Fiscal Year: 2002..This rare interdisciplinary research opportunity will allow me to contribute to the understanding of post-traumatic epilepsy while increasing my breadth and depth as a scientist. ..
- Pathophysiology of glia following traumatic brain injuryRAIMONDO D AMBROSIO; Fiscal Year: 2005..Investigations on these post-traumatic changes will allow a more rational treatment to TBI. ..
- Posttraumatic epilepsy induced by fluid percussion injury in the ratRAIMONDO D apos AMBROSIO; Fiscal Year: 2010..abstract_text> ..
- Antiepileptogenic & Disease Modifying Effects of AEDsAsla Pitkanen; Fiscal Year: 2005..abstract_text> ..
- MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMANancy Temkin; Fiscal Year: 2004..abstract_text> ..
- Post Traumatic Nonconvulsive Epileptiform ActivityPaul Vespa; Fiscal Year: 2005..The hypothesis and unique approach come at a crucial time of failed clinical trials and address an important new therapeutic target. ..
- RCT Methylphenidate & Memory/Attention Training in Traumatic Brain InjuryThomas McAllister; Fiscal Year: 2010..Further, it will help to clarify underlying neural mechanisms and suggest additional treatment possibilities. ..
- MRS Detects Metabolic Dysfunction after Brain InjuryPaul Vespa; Fiscal Year: 2009..The knowledge from the proposed studies will have widespread application to critical care of neurotrauma patients. ..
- DOPAMINERGIC MODULATION WORKING MEMORY TBI--FMRI STUDYThomas McAllister; Fiscal Year: 2003..Performance and fMRI visualized activation of WM circuitry will be characterized at baseline (on placebo) and following administration of a dopamine agonist. ..
- Gender Differences in Dopamine Function after TBIAmy Wagner; Fiscal Year: 2003....
- Candidate genetic polymorphisms/ HIV-associated dementiaRamon Diaz Arrastia; Fiscal Year: 2002..These studies, is if successful, will provide genetic evidence for a role of specific inflammatory mediators in HAD, and may identify novel targets for therapeutic intervention. ..
- Optical Intrinsic Signal Imaging of SeizureJames Chen; Fiscal Year: 2006..This project will be conducted at the UCLA School of Medicine under Drs. Toga and Wasterlain's guidance. Both mentors are internationally known authorities in their respective fields of research. ..
- Effect of Biomechanical Force Exposure on Cognition & Brain Activation in StudentThomas McAllister; Fiscal Year: 2009..Impact parameters will be directly measured using helmet-based accelerometer units. ..
- Genetic factors in outcome from traumatic brain injuryRamon Diaz Arrastia; Fiscal Year: 2008..These studies may provide genetic evidence for a role of specific genes in tissue response after TBI, and may identify novel targets for therapeutic intervention. ..
- Role of Candidate Alleles in Cognitive Outcome After TBIThomas McAllister; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Dopamine Genetic Variants Modulating Recovery After TBIAmy Wagner; Fiscal Year: 2008..Through neurolmaging, we hope to better understand how genetics Influences who may benefit from a relevant rehabilitation-based pharmacological treatment strategy. [unreadable] [unreadable] [unreadable]..
- Measuring Striatal Neurotransmission in Behaving Rats after Experimental TBIAmy Wagner; Fiscal Year: 2008..The overarching goal is to gain insight into potential mechanisms of action and efficacy of these interventions on cognition and recovery for the clinical population with TBI. [unreadable] [unreadable] [unreadable]..
- Dopamine Function in TBI--Therapeutic InterventionAmy Wagner; Fiscal Year: 2005..The Departments of Physical Medicine and Rehabilitation, Neurosurgery, Anesthesia/Critical Care Medicine, and Safar Center for Resuscitation Research provide the environment for this study of experimental and clinical brain injury. ..
- The neurobiology of disease: a comprehensive graduate curriculumMarc Dichter; Fiscal Year: 2006..Students will discuss how treatments have been developed in the past, and how their research in a laboratory can help to lead to new treatment in the future. [unreadable] [unreadable]..
- Hyperhomocysteinemia in Alzheimer's DiseaseRamon Diaz Arrastia; Fiscal Year: 2003..Each of these specific aims is essential to rationally design a large multicenter trial to determine whether polyvitamin therapy lowers AD risk. ..
- ADENOSINE AND TRAUMATIC BRAIN INJURYPatrick Kochanek; Fiscal Year: 2007..These studies explore the most promising adenosine-based therapy for TBI-A2a receptor antagonists. Our bench to bedside track record ensures translation to the clinic. [unreadable] [unreadable]..
- Terrorism and Traumatic Responding: Exposure and Resiliency FactorsSTEVAN HOBFOLL; Fiscal Year: 2009..This will enable examination of the validity of phone estimates of diagnosis of PTSD and depression, in particular. ..