diffuse axonal injury

Summary

Summary: A relatively common sequela of blunt head injury, characterized by a global disruption of axons throughout the brain. Associated clinical features may include NEUROBEHAVIORAL MANIFESTATIONS; PERSISTENT VEGETATIVE STATE; DEMENTIA; and other disorders.

Top Publications

  1. ncbi Diffuse axonal injury in mild traumatic brain injury: a diffusion tensor imaging study
    Matilde Inglese
    Department of Radiology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosurg 103:298-303. 2005
  2. ncbi Cognitive sequelae of diffuse axonal injury
    Rainer Scheid
    Day Clinic of Cognitive Neurology, University of Leipzig, Leipzig, Germany
    Arch Neurol 63:418-24. 2006
  3. ncbi Update of neuropathology and neurological recovery after traumatic brain injury
    John T Povlishock
    Department of Anatomy and Neurobiology, Medical College of Virginia Campus of Virginia Commonwealth University, 1101 East Marshall St, PO Box 980709, Richmond, VA 23298, USA
    J Head Trauma Rehabil 20:76-94. 2005
  4. pmc Therapy development for diffuse axonal injury
    Douglas H Smith
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA
    J Neurotrauma 30:307-23. 2013
  5. ncbi Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury
    Thierry A G M Huisman
    MGH NMR Center, Division of Neuroradiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    AJNR Am J Neuroradiol 25:370-6. 2004
  6. ncbi Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injury
    Robert H Garman
    Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Neurotrauma 28:947-59. 2011
  7. ncbi Diffusion tensor imaging of diffuse axonal injury in a rat brain trauma model
    Yohan Van de Looij
    Grenoble Institute of Neuroscience, Research Center, INSERM U836 UJF CEA CHU, Grenoble, France
    NMR Biomed 25:93-103. 2012
  8. ncbi Continued in situ DNA fragmentation of microglia/macrophages in white matter weeks and months after traumatic brain injury
    Stephen Wilson
    Department of Neuropathology, University of Glasgow, Scotland, United Kingdom
    J Neurotrauma 21:239-50. 2004
  9. ncbi Perisomatic thalamic axotomy after diffuse traumatic brain injury is associated with atrophy rather than cell death
    Jonathan Lifshitz
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Research Center, Lexington, Kentucky, USA
    J Neuropathol Exp Neurol 66:218-29. 2007
  10. ncbi Diffuse axonal injury in head trauma
    Douglas H Smith
    Department of Neurosurgery, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA 19104, USA
    J Head Trauma Rehabil 18:307-16. 2003

Detail Information

Publications223 found, 100 shown here

  1. ncbi Diffuse axonal injury in mild traumatic brain injury: a diffusion tensor imaging study
    Matilde Inglese
    Department of Radiology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosurg 103:298-303. 2005
    b>Diffuse axonal injury (DAI) is a major complication of traumatic brain injury (TBI) that leads to functional and psychological deficits...
  2. ncbi Cognitive sequelae of diffuse axonal injury
    Rainer Scheid
    Day Clinic of Cognitive Neurology, University of Leipzig, Leipzig, Germany
    Arch Neurol 63:418-24. 2006
    The results of recent studies on cognitive disability after traumatic brain injury-associated diffuse axonal injury (DAI) are inconsistent. In these studies, the diagnosis of DAI relied on cranial computed tomography.
  3. ncbi Update of neuropathology and neurological recovery after traumatic brain injury
    John T Povlishock
    Department of Anatomy and Neurobiology, Medical College of Virginia Campus of Virginia Commonwealth University, 1101 East Marshall St, PO Box 980709, Richmond, VA 23298, USA
    J Head Trauma Rehabil 20:76-94. 2005
    ....
  4. pmc Therapy development for diffuse axonal injury
    Douglas H Smith
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA
    J Neurotrauma 30:307-23. 2013
    b>Diffuse axonal injury (DAI) remains a prominent feature of human traumatic brain injury (TBI) and a major player in its subsequent morbidity...
  5. ncbi Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury
    Thierry A G M Huisman
    MGH NMR Center, Division of Neuroradiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    AJNR Am J Neuroradiol 25:370-6. 2004
    ..Our objective was to determine if changes in anisotropic diffusion in TBI correlate with acute Glasgow coma scale (GCS) and/or Rankin scores at discharge...
  6. ncbi Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injury
    Robert H Garman
    Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Neurotrauma 28:947-59. 2011
    ..heavily stained with amino cupric silver, with the morphologic staining patterns suggesting a process of diffuse axonal injury. Silver-stained sections revealed mild multifocal neuronal death at 24 h and 72 h...
  7. ncbi Diffusion tensor imaging of diffuse axonal injury in a rat brain trauma model
    Yohan Van de Looij
    Grenoble Institute of Neuroscience, Research Center, INSERM U836 UJF CEA CHU, Grenoble, France
    NMR Biomed 25:93-103. 2012
    ..histology results and the characteristics of the impact-acceleration model responsible for the presence of diffuse axonal injury, the detection of low FA caused by a drastic reduction in axial diffusivity and the presence of fiber ..
  8. ncbi Continued in situ DNA fragmentation of microglia/macrophages in white matter weeks and months after traumatic brain injury
    Stephen Wilson
    Department of Neuropathology, University of Glasgow, Scotland, United Kingdom
    J Neurotrauma 21:239-50. 2004
    ..However, in addition, a few TUNEL+ oligodendrocyte-like cells were also seen...
  9. ncbi Perisomatic thalamic axotomy after diffuse traumatic brain injury is associated with atrophy rather than cell death
    Jonathan Lifshitz
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Research Center, Lexington, Kentucky, USA
    J Neuropathol Exp Neurol 66:218-29. 2007
    Morbidity and mortality associated with traumatic brain injury (TBI) stem from diffuse axonal injury (DAI) throughout subcortical and brainstem white matter and subcortical nuclei...
  10. ncbi Diffuse axonal injury in head trauma
    Douglas H Smith
    Department of Neurosurgery, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA 19104, USA
    J Head Trauma Rehabil 18:307-16. 2003
    b>Diffuse axonal injury (DAI) is one of the most common and important pathologic features of traumatic brain injury (TBI)...
  11. ncbi Diffusion-tensor imaging implicates prefrontal axonal injury in executive function impairment following very mild traumatic brain injury
    Michael L Lipton
    Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Radiology 252:816-24. 2009
    ..To determine whether frontal white matter diffusion abnormalities can help predict acute executive function impairment after mild traumatic brain injury (mTBI)...
  12. pmc Mild traumatic brain injury and diffuse axonal injury in swine
    Kevin D Browne
    Center for Brain Injury and Repair, Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 28:1747-55. 2011
    ..Although little is known about the pathophysiological aspects of mTBI, there is growing opinion that diffuse axonal injury (DAI) may play a key role...
  13. ncbi Prediction of recovery from a post-traumatic coma state by diffusion-weighted imaging (DWI) in patients with diffuse axonal injury
    W B Zheng
    Department of Radiology, Second Hospital, Shantou University Medical College, Shantou, 515041, Guangdong, China
    Neuroradiology 49:271-9. 2007
    ..diffusion-weighted magnetic resonance (MR) imaging findings combined with initial clinical factors indicate the depth of shearing lesions in the brain structure and therefore relate to coma duration in diffuse axonal injury (DAI).
  14. ncbi Motor recovery mechanism of diffuse axonal injury: a combined study of transcranial magnetic stimulation and functional MRI
    Sung Ho Jang
    Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Republic of Korea
    Restor Neurol Neurosci 23:51-6. 2005
    The purpose of this study was to investigate the motor recovery mechanism following diffuse axonal injury (DAI) using transcranial magnetic stimulation (TMS) and functional MRI (fMRI).
  15. ncbi Immediate coma following inertial brain injury dependent on axonal damage in the brainstem
    D H Smith
    Department of Neurosurgery, University of Pennsylvania, Philadelphia 19104, USA
    J Neurosurg 93:315-22. 2000
    Immediate and prolonged coma following brain trauma has been shown to result from diffuse axonal injury (DAI). However, the relationship between the distribution of axonal damage and posttraumatic coma has not been examined...
  16. pmc Partial interruption of axonal transport due to microtubule breakage accounts for the formation of periodic varicosities after traumatic axonal injury
    Min D Tang-Schomer
    Penn Center for Brain Injury and Repair and Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Neurol 233:364-72. 2012
    ..Indeed, diffuse axonal injury (DAI) is one of the most common features of TBI, characterized by the hallmark pathological profiles of ..
  17. ncbi Experimental models of traumatic axonal injury
    Hong Cai Wang
    Department of Neurosurgery, No 3 People s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Baoshan, Shanghai 201900, China
    J Clin Neurosci 17:157-62. 2010
    ..Traumatic axonal injury (TAI), originally described as diffuse axonal injury, is one of the most common pathological features of TBI and is thought to be responsible for the long-..
  18. ncbi Is traumatic axonal injury (AI) associated with an early microglial activation? Application of a double-labeling technique for simultaneous detection of microglia and AI
    M Oehmichen
    Institute of Forensic Medicine, Medical University of Lubeck, Germany
    Acta Neuropathol 97:491-4. 1999
    ....
  19. ncbi Diffuse axonal injury: novel insights into detection and treatment
    Xue Yuan Li
    Department of Neurosurgery, No 3 People s Hospital Affiliated to Shanghai Jiao Tong University College of Medicine, Shanghai 201900, China
    J Clin Neurosci 16:614-9. 2009
    b>Diffuse axonal injury (DAI) is one of the most common and important pathologic features of traumatic brain injury. The definitive diagnosis of DAI, especially in its early stage, is difficult...
  20. pmc A possible role for integrin signaling in diffuse axonal injury
    Matthew A Hemphill
    Disease Biophysics Group, School of Engineering and Applied Sciences, Wyss Institute of Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS ONE 6:e22899. 2011
    ..These data suggest that integrin-mediated activation of Rho may be a contributor to the diffuse axonal injury reported in mild Traumatic Brain Injury.
  21. ncbi Diffuse axonal injury in children: clinical correlation with hemorrhagic lesions
    Karen A Tong
    Department of Radiology, Loma Linda University Medical Center, 11234 Anderson Street, Loma Linda, CA 92354, USA
    Ann Neurol 56:36-50. 2004
    An inception cohort of 40 children and adolescents with traumatic brain injury and suspected diffuse axonal injury were studied using a new high-resolution magnetic resonance imaging susceptibility-weighted technique that is very ..
  22. pmc Detection of blast-related traumatic brain injury in U.S. military personnel
    Christine L Mac Donald
    Washington University School of Medicine, St Louis, MO 63110, USA
    N Engl J Med 364:2091-100. 2011
    ..Blast-related traumatic brain injuries have been common in the Iraq and Afghanistan wars, but fundamental questions about the nature of these injuries remain unanswered...
  23. pmc Chronic upregulation of activated microglia immunoreactive for galectin-3/Mac-2 and nerve growth factor following diffuse axonal injury
    Charu Venkatesan
    Division of Neurology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA
    J Neuroinflammation 7:32. 2010
    b>Diffuse axonal injury in patients with traumatic brain injury (TBI) can be associated with morbidity ranging from cognitive difficulties to coma...
  24. ncbi Mechanisms of blast induced brain injuries, experimental studies in rats
    M Risling
    Department of Neuroscience, Karolinska Institutet, Stockholm S 171 77, Sweden
    Neuroimage 54:S89-97. 2011
    ..Immunohistochemical labeling for amyloid precursor protein revealed signs of diffuse axonal injury (DAI) in the penetration and rotation models...
  25. ncbi Traumatic axonal injury induces calcium influx modulated by tetrodotoxin-sensitive sodium channels
    J A Wolf
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 21:1923-30. 2001
    b>Diffuse axonal injury (DAI) is one of the most common and important pathologies resulting from the mechanical deformation of the brain during trauma...
  26. ncbi Post-traumatic hypoxia exacerbates brain tissue damage: analysis of axonal injury and glial responses
    Sarah C Hellewell
    National Trauma Research Institute, The Alfred Hospital, Melbourne, Victoria, Australia
    J Neurotrauma 27:1997-2010. 2010
    ....
  27. ncbi Diffusion tensor MR imaging in diffuse axonal injury
    Konstantinos Arfanakis
    Department of Medical Physics, University of Wisconsin, Madison 53706 1532, USA
    AJNR Am J Neuroradiol 23:794-802. 2002
    Disruption of the cytoskeletal network and axonal membranes characterizes diffuse axonal injury (DAI) in the first few hours after traumatic brain injury...
  28. ncbi MR imaging in the detection of diffuse axonal injury with mild traumatic brain injury
    Naile Bolca Topal
    Department of Radiology, Uludag University Medical School, 16059 Gorukle, Bursa, Turkey
    Neurol Res 30:974-8. 2008
    To evaluate the occurrence and distribution of mild traumatic brain injury (MTBI) caused by diffuse axonal injury (DAI) using magnetic resonance (MR) imaging and to attempt to correlate MR findings with post-concussion symptoms (PCS).
  29. pmc Diffuse traumatic axonal injury in the mouse induces atrophy, c-Jun activation, and axonal outgrowth in the axotomized neuronal population
    John E Greer
    Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia 23298 0709, USA
    J Neurosci 31:5089-105. 2011
    ..Collectively, these TAI-linked events are consistent with sustained neuronal recovery, an activation of a regenerative genetic program, and subsequent axonal reorganization suggestive of some form of regenerative response...
  30. ncbi All roads lead to disconnection?--Traumatic axonal injury revisited
    A Buki
    Department of Anatomy and Neurobiology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA, USA
    Acta Neurochir (Wien) 148:181-93; discussion 193-4. 2006
    Traumatic brain injury (TBI) evokes widespread/diffuse axonal injury (TAI) significantly contributing to its morbidity and mortality...
  31. ncbi Prevalence and impact of diffuse axonal injury in patients with moderate and severe head injury: a cohort study of early magnetic resonance imaging findings and 1-year outcome
    Toril Skandsen
    Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
    J Neurosurg 113:556-63. 2010
    ..The objective was to explore the occurrence of diffuse axonal injury (DAI) and determine whether DAI was related to level of consciousness and patient outcome.
  32. ncbi A longitudinal fMRI study of working memory in severe TBI patients with diffuse axonal injury
    Rocio Sanchez-Carrion
    Department of Neuropsychology, Institut Universitari de Neurorehabilitació Guttmann, Badalona, Spain
    Neuroimage 43:421-9. 2008
    ..All the TBI patients selected presented signs of diffuse axonal injury on CT but had no evidence of focal lesions on MRI clinical examination...
  33. ncbi Diffuse vascular injury in fatal road traffic accident victims: its relationship to diffuse axonal injury
    José E H Pittella
    Laboratory of Neuropathology, Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil
    J Forensic Sci 48:626-30. 2003
    ..The 14 patients with DVI also showed severe (Grade 2 or 3) diffuse axonal injury (DAI)...
  34. ncbi Diffuse axonal injury induced by simultaneous moderate linear and angular head accelerations in rats
    X Y Li
    Department of Neurosurgery, No 3 People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
    Neuroscience 169:357-69. 2010
    b>Diffuse axonal injury (DAI) is one of the most common and important pathologic features of human traumatic brain injury (TBI), accounting for high mortality and development of persistent post-traumatic neurologic sequelae...
  35. ncbi Brain MR diffusion tensor imaging and fibre tracking to differentiate between two diffuse axonal injuries
    D Ducreux
    Department of Neuroradiology, CHU de Bicetre, Paris XI University, 94270 Le Kremlin Bicetre, France
    Neuroradiology 47:604-8. 2005
    We report here two cases of diffuse axonal injury (DAI) studied by MR diffusion tensor imaging (DTI) and fibre tracking (FT) focused on the corpus callosum...
  36. ncbi Diffusion-weighted MRI in diffuse axonal injury of the brain
    K Hergan
    Department of Radiology, Neuroradiology Section and MGH NMR Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Mailcode 149 2301, Boston, MA 02129, USA
    Eur Radiol 12:2536-41. 2002
    ..different types and patterns of tissue injury which are encountered by diffusion-weighted imaging (DWI) in diffuse axonal injury (DAI) of the brain...
  37. ncbi Cleft cavum of the septum pellucidum in victims of fatal road traffic accidents: a distinct type of cavum associated with severe diffuse axonal injury
    José Eymard Homem Pittella
    Laboratory of Neuropathology, Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Minas Gerais, Minas Gerais, 30130 100 Belo Horizonte, Minas Gerais, Brazil
    Surg Neurol 63:S30-4; discussion S34-5. 2005
    ..The cavum of the septum pellucidum (CSP) is a small cavity constantly present in fetuses and newborns, of variable frequency among necropsied adults and with a high frequency in professional boxers...
  38. ncbi The conformation of the brain plays an important role in the distribution of diffuse axonal injury in fatal road traffic accident
    José Eymard Homem Pittella
    Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    Arq Neuropsiquiatr 62:406-12. 2004
    ..A study was made of the brain lesions in 120 random victims of fatal road traffic accidents to determine the frequency and topographic distribution of diffuse axonal damage (DAI) in relation to the midline brain structures...
  39. ncbi Diffuse axonal injury associated with chronic traumatic brain injury: evidence from T2*-weighted gradient-echo imaging at 3 T
    Rainer Scheid
    Day Clinic of Cognitive Neurology, University of Leipzig, Liebigstrasse 22a, 04103 Leipzig, Germany
    AJNR Am J Neuroradiol 24:1049-56. 2003
    b>Diffuse axonal injury is frequently accompanied by tissue tear hemorrhages...
  40. ncbi Neural injury of uncinate fasciculus in patients with diffuse axonal injury
    Jeong Pyo Seo
    Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Taegu, Republic of Korea
    NeuroRehabilitation 30:323-8. 2012
    ..We investigated injuries of the UF in patients with diffuse axonal injury (DAI) who showed no specific lesions except for DAI lesions on conventional brain MRI...
  41. ncbi High expression of STIM1 in the early stages of diffuse axonal injury
    Yu Li
    Department of Neurosurgery, the First Affiliated Hospital of the Medical College of Xi an Jiaotong University, Xi an 710061, PR China
    Brain Res 1495:95-102. 2013
    ..Ca(2+)](i)) is a key pathological mechanism involved in secondary neuronal injury and cell death due to diffuse axonal injury (DAI)...
  42. pmc Diffuse axonal injury in mild traumatic brain injury: a 3D multivoxel proton MR spectroscopy study
    Ivan I Kirov
    Department of Radiology, New York University School of Medicine, 660 First Avenue, 4th Floor, New York, NY 10016, USA
    J Neurol 260:242-52. 2013
    ..often leads to neurological symptoms even without clinical MRI findings, our goal was to test whether diffuse axonal injury is quantifiable with multivoxel proton MR spectroscopic imaging ((1)H-MRSI)...
  43. ncbi Cerebral blood flow in patients with diffuse axonal injury--examination of the easy Z-score imaging system utility
    T Okamoto
    Department of Rehabilitation Medicine, Kanagawa Rehabilitation Hospital, Atsugi, Japan
    Eur J Neurol 14:540-7. 2007
    To evaluate the utility of easy Z-score imaging system (eZIS) in 27 diffuse axonal injury (DAI) cases...
  44. ncbi Neuron-specific enolase and S100BB as outcome predictors in severe diffuse axonal injury
    Shahrokh Yousefzadeh Chabok
    Department of Neurosurgery, Guilan University of Medical Sciences, Rasht, Guilan, Iran
    J Trauma Acute Care Surg 72:1654-7. 2012
    b>Diffuse axonal injury (DAI) is a common type of traumatic brain injury, mostly associated with mild changes on computed tomography (CT) scan. Serum biomarkers might be used in the diagnosis and prognosis of this injury type...
  45. ncbi Cerebellar peduncle injury in patients with ataxia following diffuse axonal injury
    Ji Heon Hong
    Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daemyungdong, Namku, Taegu, Republic of Korea
    Brain Res Bull 80:30-5. 2009
    No diffusion tensor imaging (DTI) study has yet investigated ataxia in diffuse axonal injury (DAI). In the current study, we used DTI to investigate cerebellar peduncle lesions of patients who showed severe ataxia following DAI...
  46. ncbi Extent of nerve cell injury in Marmarou's model compared to other brain trauma models
    Jose A Rafols
    Department of Anatomy and Cell Biology, Scott Hall, Room No 9312, Wayne State University School of Medicine, 540 E Canfield, Detroit, MI 48201, USA
    Neurol Res 29:348-55. 2007
    ..We sought to determine the extent of nerve cell injury in the Marmarou's acceleration impact model of diffuse brain injury...
  47. ncbi Effect of progesterone administration on prognosis of patients with diffuse axonal injury due to severe head trauma
    Moslem Shakeri
    Department of Neurosurgery, Imam Reza Teaching Hospital, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
    Clin Neurol Neurosurg 115:2019-22. 2013
    ..The aim of this clinical study was to assess the effect of progesterone on the improvement of neurologic outcome in patients with acute severe TBI...
  48. ncbi A substance P antagonist reduces axonal injury and improves neurologic outcome when administered up to 12 hours after traumatic brain injury
    James J Donkin
    Discipline of Anatomy and Pathology, University of Adelaide, Adelaide, South Australia, Australia
    J Neurotrauma 28:217-24. 2011
    ..We conclude that the neuroprotective effects of NAT are receptor-mediated, and that administration of the membrane-permeable form of the compound can be effective even up to 12 h after TBI...
  49. ncbi Current concepts: diffuse axonal injury-associated traumatic brain injury
    J M Meythaler
    Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham School of Medicine, 35249 7330, USA
    Arch Phys Med Rehabil 82:1461-71. 2001
    To review the probable physical, physiologic mechanisms that result in the medical and neuropsychologic complications of diffuse axonal injury (DAI)-associated traumatic brain injury (TBI).
  50. pmc Inflammatory response following diffuse axonal injury
    Yu Lin
    School of Medicine, Zhejiang University City College, China
    Int J Med Sci 10:515-21. 2013
    ....
  51. ncbi Biomarkers associated with diffuse traumatic axonal injury: exploring pathogenesis, early diagnosis, and prognosis
    Jia Li
    Department of Neurosurgery, No 3 People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Trauma 69:1610-8. 2010
    ..To address these issues, many investigations have sought to identify biomarkers of dTAI...
  52. ncbi Brain activations in errorless and errorful learning in patients with diffuse axonal injury: a functional MRI study
    Hiroki Ueno
    Department of Clinical Neuroscience and Therapeutics, Hiroshima University, Graduate School of Biomedical Sciences, Hiroshima, Japan
    Brain Inj 23:291-8. 2009
    ..This study compared brain activations in errorless learning (EL) and errorful learning (EF) in patients with diffuse axonal injury (DAI) using a functional magnetic resonance imaging (fMRI).
  53. ncbi A case of diffuse axonal injury in violent death
    Kaori Mochizuki
    Legal Medicine, Department of Social and Environmental Medicine, Division of Preventive and Environmental Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Leg Med (Tokyo) 11:S518-9. 2009
    ..We found sinusoidal swelling of axons and waving axons, which are typical findings of Diffuse Axonal Injury (DAI), but no positive staining of beta amyloid...
  54. ncbi The relation between fornix injury and memory impairment in patients with diffuse axonal injury: a diffusion tensor imaging study
    Min Cheol Chang
    Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Republic of Korea
    NeuroRehabilitation 26:347-53. 2010
    Little is known about the relation between fornix injury and memory impairment in diffuse axonal injury (DAI)...
  55. ncbi Genu of corpus callosum in diffuse axonal injury induces a worse 1-year outcome in patients with traumatic brain injury
    Hidetoshi Matsukawa
    Department of Neurosurgery, St Luke s International Hospital, 9 1 Akashi cho, Chuo Ku, Tokyo 104 8560, Japan
    Acta Neurochir (Wien) 153:1687-93; discussion 1693-4. 2011
    Previous studies have shown a relationship between diffuse axonal injury (DAI) and unfavorable clinical outcome in patients with traumatic brain injury (TBI), but it remains unclear whether the type of DAI lesion influences outcome after ..
  56. ncbi Transplanted bone marrow stromal cells improves cognitive dysfunction due to diffuse axonal injury in rats
    Katsuhiko Maruichi
    Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Neuropathology 29:422-32. 2009
    b>Diffuse axonal injury (DAI) often leads to persistent cognitive dysfunction in spite of the lack of gross lesions on MRI...
  57. ncbi Corpus callosum injury in patients with diffuse axonal injury: a diffusion tensor imaging study
    Min Cheol Chang
    Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Republic of Korea
    NeuroRehabilitation 26:339-45. 2010
    Little is known about diffusion tensor image (DTI) findings of corpus callosum (CC) injury in patients with diffuse axonal injury (DAI). In the present study, we investigated the presence and extent of CC injury in patients with DAI...
  58. ncbi Diffusion tensor tractography of traumatic diffuse axonal injury
    Jun Yi Wang
    Department of Cognition and Neuroscience, The University of Texas at Dallas, Richardson, USA
    Arch Neurol 65:619-26. 2008
    b>Diffuse axonal injury is a common consequence of traumatic brain injury that frequently involves the parasagittal white matter, corpus callosum, and brainstem.
  59. pmc The pathophysiology of prospective memory failure after diffuse axonal injury--lesion-symptom analysis using diffusion tensor imaging
    Keita Kondo
    Hiroshima Higher Brain Function Center, Hiroshima Prefectural Rehabilitation Center, 295 3, Taguchi, Saijo, Higashi Hiroshima, Japan
    BMC Neurosci 11:147. 2010
    ..to determine the lesions attributable to PM failure, with the hypothesis that lesion-symptom analysis using diffusion tensor imaging (DTI) in subjects with diffuse axonal injury (DAI) can reveal the neuronal basis of PM in everyday life.
  60. ncbi Diffusion tensor imaging fiber tractography for evaluating diffuse axonal injury
    Ken Sugiyama
    Department of Physical Medicine and Rehabilitation, Tohoku University Graduate School of Medicine, Sendai, Japan
    Brain Inj 21:413-9. 2007
    Patients with Diffuse axonal injury (DAI) frequently exhibit cognitive disorders chronically. Radiologic recognition of DAI can help understand the clinical syndrome and to make treatment decisions...
  61. ncbi Diffuse axonal injury due to traumatic brain injury alters inhibition of imitative response tendencies
    Matthias L Schroeter
    Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstr 1a, 04103 Leipzig, Germany
    Neuropsychologia 45:3149-56. 2007
    ..We selected a patient group solely with diffuse axonal injury, as this type of injury is homogenous and is correlated with cognitive dysfunction more than focal ..
  62. ncbi Clinical features of diffuse axonal injury
    S Jing
    Department of Neurosurgery, First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041, China
    Chin J Traumatol 4:204-7. 2001
    OBJECTIVE: To analyze the mechanism of diffuse axonal injury (DAI) and study the relationship between DAI and brain concussion, brain contusion, and primary brain stem injury...
  63. ncbi Quantitative evaluation of microscopic injury with diffusion tensor imaging in a rat model of diffuse axonal injury
    Jia Li
    Department of Neurosurgery, No 3 People s Hospital, Shanghai Jiao Tong University School of Medicine, No 280 Mo He Road, Shanghai 201900, China
    Eur J Neurosci 33:933-45. 2011
    b>Diffuse axonal injury (DAI) is the predominant effect of severe traumatic brain injury and contributes significantly to neurological deficits. However, it is difficult to diagnose or characterize non-invasively with conventional imaging...
  64. ncbi Focal lesions of the corticospinal tract demonstrated by diffusion tensor imaging in patients with diffuse axonal injury
    Young Hwan Ahn
    Department of Neurosurgery, School of Medicine, Ajou University, Suwon City, Republic of Korea
    NeuroRehabilitation 21:239-43. 2006
    ..The purpose of this study was to demonstrate focal lesions of the CST in patients with diffuse axonal injury (DAI), using DTI with FT.
  65. ncbi Longitudinal study of the diffusion tensor imaging properties of the corpus callosum in acute and chronic diffuse axonal injury
    Johan Ljungqvist
    Department of Neurosurgery, Sahlgrenska University Hospital, Goteborg, Sweden
    Brain Inj 25:370-8. 2011
    Magnetic resonance diffusion tensor imaging (MR-DTI) is used increasingly to detect diffuse axonal injury (DAI) after traumatic brain injury (TBI).
  66. ncbi The neuropsychology of blunt head injury in the early postacute stage: effects of focal lesions and diffuse axonal injury
    C W Wallesch
    Department of Neurology, Otto von Guericke University, Magdeburg, Germany
    J Neurotrauma 18:11-20. 2001
    ..CT data were sufficient for neuroradiological analysis focusing on the presence or absence of CT signs of diffuse axonal injury (DAI) or focal traumatic injury...
  67. pmc Semiquantitative analysis of corpus callosum injury using magnetic resonance imaging indicates clinical severity in patients with diffuse axonal injury
    M Takaoka
    Osaka Prefectural Nakakawachi Medical Centre of Acute Medicine, Osaka, Japan
    J Neurol Neurosurg Psychiatry 73:289-93. 2002
    To evaluate the hypothesis that the extent of corpus callosum injury indicates the depth of shearing lesions in the central brain structure and therefore relates to the clinical severity of diffuse axonal injury.
  68. ncbi Voxel- and atlas-based analysis of diffusion tensor imaging may reveal focal axonal injuries in mild traumatic brain injury -- comparison with diffuse axonal injury
    Kazumi Kasahara
    Department of Radiological Sciences, Graduate School of Human Health Science, Tokyo Metropolitan University, Tokyo 116 8551, Japan
    Magn Reson Imaging 30:496-505. 2012
    ..Detecting areas of the brain with abnormalities that can explain symptoms and behavior in patients with MTBI is important in order to confirm the diagnosis of MTBI...
  69. ncbi Effects of diffuse axonal injury on speed of information processing following severe traumatic brain injury
    Kim L Felmingham
    Brain Injury Rehabilitation Service, Westmead Hospital, Westmead, NSW, Australia
    Neuropsychology 18:564-71. 2004
    To test the hypothesis that slowed information processing in traumatic brain injury is related to diffuse axonal injury (DAI), the authors compared 10 patients with predominant DAI (diffuse group) and minimal DAI (mixed injury group) on ..
  70. pmc Rostrocaudal analysis of corpus callosum demyelination and axon damage across disease stages refines diffusion tensor imaging correlations with pathological features
    Mingqiang Xie
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    J Neuropathol Exp Neurol 69:704-16. 2010
    ....
  71. ncbi Hemorrhagic shearing lesions in children and adolescents with posttraumatic diffuse axonal injury: improved detection and initial results
    Karen A Tong
    Department of Radiology, Loma Linda University Medical Center, 11234 Anderson St, CA 92354, USA
    Radiology 227:332-9. 2003
    ..SW) magnetic resonance (MR) imaging technique with that of a conventional gradient-recalled-echo (GRE) MR imaging technique for detection of hemorrhage in children and adolescents with diffuse axonal injury (DAI).
  72. pmc Diffuse axonal injury in periventricular leukomalacia as determined by apoptotic marker fractin
    Robin L Haynes
    Department of Pathology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Res 63:656-61. 2008
    ..We conclude that diffuse axonal injury, as determined by apoptotic marker fractin, occurs in PVL and that its cause likely includes primary ..
  73. pmc Diffusion tensor imaging reliably detects experimental traumatic axonal injury and indicates approximate time of injury
    Christine L Mac Donald
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    J Neurosci 27:11869-76. 2007
    ..Remarkably, DTI changes strongly predicted the approximate time since trauma. These results provide an important validation of DTI for pericontusional TAI and suggest novel clinical and forensic applications...
  74. ncbi Role of diffusion-weighted magnetic resonance imaging in diffuse axonal injury
    Y Ezaki
    Department of Neurosurgery, Nagasaki University Graduate School of Medicine, Nagasaki, Japan
    Acta Radiol 47:733-40. 2006
    ..resonance imaging (MRI), including fluid attenuated inversion recovery (FLAIR), T2*-weighted gradient echo (GE) imaging, and diffusion-weighted imaging (DWI) in diffuse axonal injury (DAI) patients correlate with the clinical outcome.
  75. ncbi Inhibition of cyclooxygenase 2 by nimesulide improves cognitive outcome more than motor outcome following diffuse traumatic brain injury in rats
    Ibolja Cernak
    Department of Neuroscience, Georgetown University, Washington DC, USA
    Exp Brain Res 147:193-9. 2002
    ..We conclude that COX-2 is involved in the development of functional deficits following diffuse TBI, particularly cognitive deficits, and that these can be improved by administration of COX-2 inhibitors...
  76. ncbi The effect of varying impact energy on diffuse axonal injury in the rat brain: a preliminary study
    Srinivasu Kallakuri
    Bioengineering Center, 818 W Hancock, Wayne State University, Detroit, MI 48201, USA
    Exp Brain Res 148:419-24. 2003
    b>Diffuse axonal injury (DAI) is seen as widespread damage in the white matter of brain characterized by morphological changes to axons throughout the brain and brain stem...
  77. pmc Compensatory cortical activation during performance of an attention task by patients with diffuse axonal injury: a functional magnetic resonance imaging study
    M Maruishi
    Hiroshima Higher Brain Function Center, Taguchi, Saijo, Higashihiroshima, Japan
    J Neurol Neurosurg Psychiatry 78:168-73. 2007
    To determine how cortical compensation occurs in higher cognitive systems during the recovery phase of diffuse axonal injury (DAI).
  78. ncbi Relationship between maximum intracranial pressure and traumatic lesions detected by T2*-weighted imaging in diffuse axonal injury
    Youchi Yanagawa
    Department of Traumatology and Critical Care Medicine, National Defense Medical College NDMC, Tokorozawa, Saitama, Japan
    J Trauma 66:162-5. 2009
    We prospectively investigated whether the number of traumatic lesions detected by magnetic resonance imaging correlated with the level of intracranial pressure (ICP) and outcome among patients with diffuse axonal injury (DAI).
  79. ncbi Conspicuity of diffuse axonal injury lesions on diffusion-weighted MR imaging
    Toshibumi Kinoshita
    Department of Radiology, Division of Neuroradiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 648, Rochester, NY 14642, USA
    Eur J Radiol 56:5-11. 2005
    1) To detect diffuse axonal injury (DAI) lesions by diffusion-weighted imaging (DWI), as compared with fluid-attenuated inversion recovery (FLAIR) imaging and (2) to evaluate hemorrhagic DAI lesions by b0 images obtained from DWI, as ..
  80. ncbi Delayed presentation of diffuse axonal injury: a case report
    Jill Corbo
    Department of Emergency Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY 10462, USA
    Ann Emerg Med 44:57-60. 2004
    This report highlights a case of delayed onset of diffuse axonal injury in the apparent absence of direct head trauma...
  81. ncbi Shaken baby syndrome: re-examination of diffuse axonal injury as cause of death
    Manfred Oehmichen
    Institute of Legal Medicine, University Hospital of Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Acta Neuropathol 116:317-29. 2008
    The discussion surrounding shaken baby syndrome (SBS) arose from the lack of evidence implicating diffuse axonal injury (DAI) as a cause of death...
  82. ncbi Proton MR spectroscopic imaging depicts diffuse axonal injury in children with traumatic brain injury
    Barbara A Holshouser
    Department of Radiology, Section of Neuroradiology, Loma Linda University School of Medicine, Loma Linda, CA 92354, USA
    AJNR Am J Neuroradiol 26:1276-85. 2005
    b>Diffuse axonal injury (DAI) after traumatic brain injury (TBI) is important in patient assessment and prognosis, yet they are underestimated with conventional imaging techniques...
  83. ncbi Diffusion-weighted imaging for the evaluation of diffuse axonal injury in closed head injury
    Thierry A G M Huisman
    Department of Radiology, Neuroradiology Section, and MGH NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown Boston, USA
    J Comput Assist Tomogr 27:5-11. 2003
    ..The purpose of this work was to compare diffusion-weighted imaging (DWI) with conventional MRI in the detection of shearing injuries in acute closed head injuries...
  84. ncbi Correlation between diffusion-tensor magnetic resonance imaging and motor-evoked potential in chronic severe diffuse axonal injury
    Yu To Yasokawa
    Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu 505 0034, Japan
    J Neurotrauma 24:163-73. 2007
    We conducted a study to evaluate the degree of corticospinal tract (CST) dysfunction associated with diffuse axonal injury (DAI) through analyses of both diffusion-tensor magnetic resonance imaging (DTMRI) and motor-evoked potential (MEP)..
  85. ncbi Diffuse axonal injury: detection of changes in anisotropy of water diffusion by diffusion-weighted imaging
    J H M Chan
    Department of Diagnostic Radiology, Tuen Mun Hospital, Tsing Chung Koon Road, Tuen Mun, N T, Hong Kong, China
    Neuroradiology 45:34-8. 2003
    ..patients with head injury to explore the feasibility of using water diffusion anisotropy for quantitating diffuse axonal injury. We showed significant decrease in diffusion anisotropy indices in areas with or without signal ..
  86. ncbi [Acupuncture treatment for a patient with diffuse axonal injury]
    Hideaki Tamai
    Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, Graduate School, Tochigi 329 0498
    Masui 56:203-6. 2007
    ..a 6-year-old boy with consciousness disturbance and heavy muscle spasticity of extremities due to severe diffuse axonal injury (DAI) in whom acupuncture treatment for 6 months alleviated these symptoms remarkably...
  87. ncbi Does the neuroprotective agent erythropoietin amplify diffuse axonal injury in its early stages?
    R Shane Tubbs
    Med Hypotheses 69:1385-6. 2007
  88. ncbi Diffuse axonal injury in severe traumatic brain injury visualized using high-resolution diffusion tensor imaging
    Jian Xu
    Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Neurotrauma 24:753-65. 2007
    ..The functional outcome in patients with TBI cannot be explained by focal pathology alone, and diffuse axonal injury (DAI) is considered a major contributor to the neurocognitive deficits experienced by this group...
  89. ncbi Graded model of diffuse axonal injury for studying head injury-induced cognitive dysfunction in rats
    Katsuhiko Maruichi
    Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Neuropathology 29:132-9. 2009
    b>Diffuse axonal injury (DAI) plays a major role in the development of cognitive dysfunction, emotional difficulties and behavioral disturbances in patients following closed head injury, even when they have no definite abnormalities on ..
  90. ncbi Quantitative analysis of the relationship between intra- axonal neurofilament compaction and impaired axonal transport following diffuse traumatic brain injury
    Christina R Marmarou
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Health Center, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Neurotrauma 22:1066-80. 2005
    ..Our findings argue for the use of multiple markers when evaluating the extent of TAI or the efficacy of therapies targeting the treatment of TAI...
  91. ncbi Serial evaluation of diffusion tensor brain fiber tracking in a patient with severe diffuse axonal injury
    Shinji Naganawa
    Department of Radiology, Nagoya University School of Medicine, Nagoya, Japan
    AJNR Am J Neuroradiol 25:1553-6. 2004
    ..evaluation of diffusion tensor brain fiber tracking was performed in a 27-year-old female patient with diffuse axonal injury after a traffic accident...
  92. ncbi A new rat model for diffuse axonal injury using a combination of linear acceleration and angular acceleration
    Hong Cai Wang
    Department of Neurosurgery, N3 People s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Baoshan District, Shanghai, China
    J Neurotrauma 27:707-19. 2010
    b>Diffuse axonal injury (DAI) is a frequent form of traumatic brain injury, and is usually associated with long-lasting neurological impairments...
  93. ncbi Simulation of acute subdural hematoma and diffuse axonal injury in coronal head impact
    D R Bradshaw
    Fluid Dynamics and Acoustics Group, Institute of Sound and Vibration Research, University of Southampton, Highfield, UK
    J Biomech 34:85-94. 2001
    ..based on the hypothesis that acute subdural hematoma (ASDH) is related to cerebral vertex displacement and diffuse axonal injury (DAI) to local Green-Lagrange strain...
  94. ncbi Changes of mGluR4 and the effects of its specific agonist L-AP4 in a rodent model of diffuse brain injury
    Fei Zhou
    Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi an, PR China
    J Clin Neurosci 10:684-8. 2003
    ..Therefore, the mGluR4 specific agonists might exert neuroprotective effects after DBI. The focus of this study is to examine the changes of expression of mGluR4 after DBI and the role of its specific agonist L-AP4 in vivo...
  95. pmc Augmented neural activity during executive control processing following diffuse axonal injury
    Gary R Turner
    Rotman Research Institute, Baycrest Center for Geriatric Care, 3560 Bathurst St, Toronto, ON, M6A 2E1, Canada
    Neurology 71:812-8. 2008
    ..g., variability in injury mechanism, severity, neuropathology or chronicity), underspecified definitions of "working memory," and behavioral differences between TBI and control groups have hindered interpretation of these changes...
  96. ncbi Altered expression patterns of metabotropic glutamate receptors in diffuse brain injury
    Zhou Fei
    Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi an 710032, PR China
    Neurosci Lett 380:280-3. 2005
    ..It may provide new insight for the development of new pharmaceuticals in the treatment of DBI...
  97. ncbi Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury
    Jinglu Ai
    Traumatic Brain Injury Laboratory, Cara Phelan Centre for Trauma Research, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Neurotrauma 24:960-78. 2007
    ..Multiple drug administrations may be necessary for achieving a persisting effectiveness of this compound...
  98. ncbi Intra-axonal neurofilament compaction does not evoke local axonal swelling in all traumatically injured axons
    J R Stone
    Department of Anatomy, Campus of Virginia Commonwealth University, Richmond, Virginia 23298-0709, USA
    Exp Neurol 172:320-31. 2001
    ..This finding underscores the complexity of TAI, suggesting the need for multiple immunocytochemical approaches to fully assess the overall axonal response to TBI...
  99. ncbi Retinal haemorrhages in infant head injury
    Brian J Clark
    Brain 125:677-8; author reply 678. 2002
  100. ncbi Imaging of traumatic intracranial hemorrhage
    Robert J Young
    Department of Radiology, Saint Luke s Roosevelt Hospital Center, 1000 Tenth Avenue, New York, NY 10019, USA
    Neuroimaging Clin N Am 12:189-204. 2002
    ..MR imaging, which has always been important for the evaluation of subacute and chronic head trauma, has been gaining popularity and recognition as an alternative primary imaging modality...
  101. ncbi Time course of early metabolic changes following diffuse traumatic brain injury in rats as detected by (1)H NMR spectroscopy
    Jose M Pascual
    Department of Neurosurgery, La Princesa University Hospital, Madrid, Spain
    J Neurotrauma 24:944-59. 2007
    ..Our findings suggest that the profile of some specific brain molecules that play a role as organic osmolytes can be used to follow-up the progression of the early diffuse brain edema response induced by TBI...

Research Grants48

  1. Modulating Secondary Damage Following Traumatic Brain Injury in the Child
    Stuart H Friess; Fiscal Year: 2013
    ..of non-impact inertial head injury with subdural and subarachnoid hemorrhage, infarction, ischemia, and diffuse axonal injury, consistent with typical severe pediatric TBI...
  2. A Mouse Model for Emotional Disorder Caused by Mild Traumatic Brain Injury
    ANTON J REINER; Fiscal Year: 2013
    ..We have found that we can create hyper-anxiety and depression, and diffuse axonal injury, in 3-month old male C57BL/6 mice during the first month after 50-60 psi blast with this system...
  3. Effects of traumatic brain injury on hippocampal network activity: age difference
    Susanna Rosi; Fiscal Year: 2013
    ..the pathogenesis of TBI- related cognitive impairment is uncertain, it is likely multifaceted involving diffuse axonal injury, altered neuronal integrity, imbalances in neurotransmitters, changes on brain metabolism, hippocampal ..
  4. Molecular Mechanisms of Enhanced Contractility following Traumatic Brain Injury:
    Christian W Kreipke; Fiscal Year: 2011
    ..in three major pathologies: 1) cerebral edema which leads to a critical rise in intracranial pressure, 2) diffuse axonal injury which brings about disruption of neural circuits underlying cognitive and motoric behaviors, and 3) ..
  5. Mild TBI Alters Axonal Structure, Neuronal Electrophysiology &Vascular Function
    John T Povlishock; Fiscal Year: 2013
    ..In contrast, with more mild to moderate TBI, overt brain damage is uncommon with diffuse axonal injury representing the dominant form of change and playing a major role in any ensuing morbidity...
  6. Biological Inquiry into the Mechanisms and Neuroprotective Strategy for TBI
    Dong Feng Chen; Fiscal Year: 2013
    ..Recent studies demonstrate that diffuse axonal injury (DAI) is the most common pathologic feature largely accounting for the clinical manifestations of TBI...
  7. Neurobiology of Suicide Risk in Traumatic Brain Injury and Substance Abuse
    Deborah A Yurgelun-Todd; Fiscal Year: 2013
    ..TBI is common in returning veterans and appears to produce neurophysiological changes that resemble diffuse axonal injury (DAI)...
  8. Traumatic Brain Injury Clinical Trials Network
    Thomas Novack; Fiscal Year: 2010
    ..is high-speed transportation accidents, and these result in a mechanism of injury commonly described as diffuse axonal injury (DAI). DAI causes a reduction in the turnover of dopamine in the brain...
  9. Contribution of blast wave components to mild traumatic brain injury
    DEXTER VINCENT RENEER; Fiscal Year: 2012
    ..This will be evaluated using a range of peak overpressures. Brain injury will be assessed using markers diffuse axonal injury (DAI), blood-brain barrier (BBB) compromise, oxidative stress and neuron death...
  10. Mild traumatic brain injury and diffuse axonal injury
    DOUGLAS HAMILTON SMITH; Fiscal Year: 2012
    ..hypotheses addressing clinical and mechanistic aspects of MTBI: 1) White matter injury, specifically diffuse axonal injury (DAI), is an important pathologic substrate of MTBI, and the extent and distribution of this injury will ..
  11. A Psychiatric and Imaging Study of Pediatric Mild Traumatic Brain Injury
    Jeffrey E Max; Fiscal Year: 2013
    ..Additionally, injury variables (severity, presence of a brain lesion, extent of diffuse axonal injury) will mediate occurrence of new-onset psychiatric disorders in children with mild TBI and orthopedic ..
  12. A Longitudinal Multi-modal Neuroimaging Investigation of Functional Recovery afte
    Junghoon Kim; Fiscal Year: 2013
    ..longitudinal changes in structural and functional neuroimaging indices associated with moderate to severe diffuse axonal injury and their relationship with behavioral improvements, 2) to develop a neuropathologically based injury ..
  13. Default Mode Interference and Working Memory in Mild Traumatic Brain Injury
    Chandler Sours; Fiscal Year: 2013
    ..Although diffuse axonal injury (DAI) may be present among such patients, it is often missed by CT and conventional MRI...
  14. Neuroimaging Biomarkers of Outcome for Diffuse Axonal Injury
    CARLOS DANIEL MARQUEZ DE LA PLATA; Fiscal Year: 2012
    ..modalities, including conventional MRI and Diffusion Tensor Imaging (DTI), as a biomarker of outcome after diffuse axonal injury (DAI)...
  15. Pathology of traumatic injury to CNS axons
    Kathryn Saatman; Fiscal Year: 2007
    ..each year in the United States, many of whom suffer persistent neurological disability as a result of diffuse axonal injury. Shearing or stretching of axons during traumatic brain injury initiates progressive axonal damage, ..
  16. BRAIN INJURY, AGING AND NEURODEGENERATION IN THE RAT
    Douglas Smith; Fiscal Year: 2004
    ..Success of these studies may reveal mechanistic links between brain trauma, age and neurodegenerative processes and provide a basis for the development of new therapeutic strategies. ..
  17. Spinal cord repair with nerve constructs
    Douglas Smith; Fiscal Year: 2009
    ..abstract_text> ..
  18. DOPAMINERGIC MODULATION WORKING MEMORY TBI--FMRI STUDY
    Thomas McAllister; Fiscal Year: 2003
    ..Performance and fMRI visualized activation of WM circuitry will be characterized at baseline (on placebo) and following administration of a dopamine agonist. ..
  19. Novel MRI and 1H-MRS markers in Primary Progressive MS
    Matilde Inglese; Fiscal Year: 2009
    ..Letter of support: Prof. John DeLuca, consultant PHS 398 (Rev. 05/01) Page. Form Page 3 Use /2-inch MARGINS. Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. ..
  20. Detecting Axonal Damage After Mild Traumatic Brain Injury
    Jeffrey Bazarian; Fiscal Year: 2009
    ....
  21. Memory and attention in people who experienced a single life-threatening event
    Brian Levine; Fiscal Year: 2009
    ....
  22. Effect of Biomechanical Force Exposure on Cognition & Brain Activation in Student
    Thomas McAllister; Fiscal Year: 2009
    ..Impact parameters will be directly measured using helmet-based accelerometer units. ..
  23. RCT Methylphenidate & Memory/Attention Training in Traumatic Brain Injury
    Thomas McAllister; Fiscal Year: 2010
    ..Further, it will help to clarify underlying neural mechanisms and suggest additional treatment possibilities. ..
  24. Axon Plasticity and Recovery of Function after Traumatic Brain Injury
    Neil Harris; Fiscal Year: 2010
    ....
  25. Genetic factors in outcome from traumatic brain injury
    Ramon Diaz Arrastia; Fiscal Year: 2008
    ..These studies may provide genetic evidence for a role of specific genes in tissue response after TBI, and may identify novel targets for therapeutic intervention. ..
  26. Role of Candidate Alleles in Cognitive Outcome After TBI
    Thomas McAllister; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  27. Neuroimaging and Recovery after Pediatric Brain Injury
    Talin Babikian; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  28. Quality of Life in Patients with Brain Metastases
    Joseph King; Fiscal Year: 2005
    ..abstract_text> ..
  29. INTRALAMINAR THALAMIC INFLUENCES ON VISUAL AWARENESS
    Nicholas Schiff; Fiscal Year: 2004
    ..While these are long-range goals, and the studies proposed here do not represent direct investigations of these possibilities, completion of these experiments is necessary and logical step toward these goals. ..
  30. NEUROLOGICAL SCIENCES ACADEMIC DEVELOPMENT AWARD
    Joseph Volpe; Fiscal Year: 2003
    ..Fischbach, in research development of child neurology residents ensure the success of this NSADA program. ..
  31. MULTIDISCIPLINARY ASSESSMENT OF SEVERE BRAIN INJURY
    Nicholas Schiff; Fiscal Year: 2003
    ..The long-range goal of the studies proposed here is to provide a foundation for rational therapies for chronic cognitive disabilities following complex brain injuries. ..
  32. NEURODEGENERATION IN HIV INFECTED DRUG USERS
    Jeanne Bell; Fiscal Year: 2003
    ..Elucidation of the interaction between drugs and HIV infection of the CNS could lead to more focused strategies to prevent cognitive decline in drug users, particularly those who are also HIV infected. ..
  33. CNS MICROVASCULAR PERICYTE AND EAE
    Paula Dore Duffy; Fiscal Year: 2003
    ..The potential role of PC cytokines will be examined. ..
  34. TRAUMA TO THE DEVELOPING BRAIN--RESPONSE AND TREATMENT
    Ann Christine Duhaime; Fiscal Year: 2002
    ..This important information will be useful in the development and testing of head injury therapies appropriate for infants and children. ..
  35. Candidate genetic polymorphisms/ HIV-associated dementia
    Ramon Diaz Arrastia; Fiscal Year: 2002
    ..These studies, is if successful, will provide genetic evidence for a role of specific inflammatory mediators in HAD, and may identify novel targets for therapeutic intervention. ..
  36. Epidemiology of Traumatic Brain Injury
    Jeffrey Bazarian; Fiscal Year: 2005
    ....
  37. Amygdala Response to Experimental Traumatic Brain Injury
    Jonathan Lifshitz; Fiscal Year: 2005
    ..This research effort may lead to novel treatments for the affective disorders in an otherwise healthy brain-injured population, in addition to post-traumatic stress disorder and psychosis. ..
  38. The Neuroanatomy of Cognition in Traumatic Brain Injury
    Brian Levine; Fiscal Year: 2006
    ..Moreover, we expect these findings to increase the understanding of neural changes (i.e., neural compensation or re-organization) in response to brain injury in general. ..
  39. CONTROL OF MICROVASCULAR TONE IN TRAUMATIC BRAIN INJURY
    Jose Rafols; Fiscal Year: 2008
    ..unreadable]..
  40. Trauma to Immature Brain: Response Repair & Treatment
    Ann Christine Duhaime; Fiscal Year: 2008
    ..We believe this approach will help "bridge the gap" between rodent models and effective treatment for the many thousands of children who suffer traumatic brain injury each year. ..
  41. Neuropsychiatry of Traumatic Brain Injury
    MARILYN KRAUS; Fiscal Year: 2008
    ..This application is designed to enable the candidate to transition into an independent clinical investigator with the necessary research skills needed to study neuropathology, outcomes, and interventions. ..
  42. Age-Dependent Ketone Metabolism After Brain Injury
    Mayumi Prins; Fiscal Year: 2007
    ..abstract_text> ..
  43. Cognitive Recovery after Traumatic Brain Injury
    Maureen Schmitter Edgecombe; Fiscal Year: 2007
    ....
  44. VEGF gene expression in central nervous system microvascular pericyte
    Paula Dore Duffy; Fiscal Year: 2007
    ..We propose that the CNS microvascular pericyte is a regulatory cell important in the vascular response to hypoxic stress and that cyclopentenone prostagladins are involved in the pericyte stress response. ..
  45. Marrow stromal cell deliver to repair the spinal cord
    Jeffery Kocsis; Fiscal Year: 2007
    ..abstract_text> ..
  46. Caspase mediated cell death after brain trauma
    Ramesh Raghupathi; Fiscal Year: 2006
    ..abstract_text> ..
  47. DRUG RELATED CNS DAMAGE-SYNERGY WITH EFFECTS OF HIV
    Jeanne Bell; Fiscal Year: 2002
    ..Identification of particularly hazardous patterns of illicit drug(s) use, and of possible genetic susceptibility, could lead to more focused prevention and intervention strategies in at risk cohorts and individuals. ..
  48. Hyperhomocysteinemia in Alzheimer's Disease
    Ramon Diaz Arrastia; Fiscal Year: 2003
    ..Each of these specific aims is essential to rationally design a large multicenter trial to determine whether polyvitamin therapy lowers AD risk. ..