brain injuries

Summary

Summary: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.

Top Publications

  1. ncbi The epidemiology and impact of traumatic brain injury: a brief overview
    Jean A Langlois
    Division of Injury Response, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA30341, USA
    J Head Trauma Rehabil 21:375-8. 2006
  2. ncbi ATP mediates rapid microglial response to local brain injury in vivo
    Dimitrios Davalos
    Molecular Neurobiology Program, Department of Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Nat Neurosci 8:752-8. 2005
  3. doi Mild traumatic brain injury in U.S. Soldiers returning from Iraq
    Charles W Hoge
    Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, U S Army Medical Research and Materiel Command, Silver Spring, MD 20910, USA
    N Engl J Med 358:453-63. 2008
  4. pmc Animal models of traumatic brain injury
    Ye Xiong
    Department of Neurosurgery, E and R Building, Room 3096, Henry Ford Health System, 2799 West Grand Boulevard, Detroit, Michigan 48202, USA
    Nat Rev Neurosci 14:128-42. 2013
  5. pmc Role of microglia in neurotrauma
    David J Loane
    Department of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research STAR, National Study Center for Trauma and EMS, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Neurotherapeutics 7:366-77. 2010
  6. pmc A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury
    M E Shenton
    Clinical Neuroscience Laboratory, Department of Psychiatry, VA Boston Healthcare System, Brockton, MA, USA
    Brain Imaging Behav 6:137-92. 2012
  7. doi Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury
    Adel Helmy
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Box 167, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0QQ, UK
    Prog Neurobiol 95:352-72. 2011
  8. pmc Detection of blast-related traumatic brain injury in U.S. military personnel
    Christine L Mac Donald
    Washington University School of Medicine, St Louis, MO 63110, USA
    N Engl J Med 364:2091-100. 2011
  9. pmc White matter damage and cognitive impairment after traumatic brain injury
    Kirsi Maria Kinnunen
    Department of Psychology, Goldsmiths, University of London, London, UK
    Brain 134:449-63. 2011
  10. doi Inflammation after trauma: microglial activation and traumatic brain injury
    Anil F Ramlackhansingh
    Centre for Neuroscience, Department of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK
    Ann Neurol 70:374-83. 2011

Detail Information

Publications388 found, 100 shown here

  1. ncbi The epidemiology and impact of traumatic brain injury: a brief overview
    Jean A Langlois
    Division of Injury Response, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA30341, USA
    J Head Trauma Rehabil 21:375-8. 2006
    ..The estimated 5.3 million Americans living with TBI-related disability face numerous challenges in their efforts to return to a full and productive life. This article presents an overview of the epidemiology and impact of TBI...
  2. ncbi ATP mediates rapid microglial response to local brain injury in vivo
    Dimitrios Davalos
    Molecular Neurobiology Program, Department of Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Nat Neurosci 8:752-8. 2005
    ..Thus, extracellular ATP regulates microglial branch dynamics in the intact brain, and its release from the damaged tissue and surrounding astrocytes mediates a rapid microglial response towards injury...
  3. doi Mild traumatic brain injury in U.S. Soldiers returning from Iraq
    Charles W Hoge
    Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, U S Army Medical Research and Materiel Command, Silver Spring, MD 20910, USA
    N Engl J Med 358:453-63. 2008
    ..However, the epidemiology of combat-related mild traumatic brain injury is poorly understood...
  4. pmc Animal models of traumatic brain injury
    Ye Xiong
    Department of Neurosurgery, E and R Building, Room 3096, Henry Ford Health System, 2799 West Grand Boulevard, Detroit, Michigan 48202, USA
    Nat Rev Neurosci 14:128-42. 2013
    ..This failure in clinical translation of preclinical studies highlights a compelling need to revisit the current status of animal models of TBI and therapeutic strategies...
  5. pmc Role of microglia in neurotrauma
    David J Loane
    Department of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research STAR, National Study Center for Trauma and EMS, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Neurotherapeutics 7:366-77. 2010
    ..In that light, future research is needed to focus on clarifying the signals and mechanisms by which microglia can be guided to promote optimal functional recovery...
  6. pmc A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury
    M E Shenton
    Clinical Neuroscience Laboratory, Department of Psychiatry, VA Boston Healthcare System, Brockton, MA, USA
    Brain Imaging Behav 6:137-92. 2012
    ..to detecting diffuse axonal injuries (DAI), also described as traumatic axonal injuries (TAI), the major brain injuries in mTBI...
  7. doi Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury
    Adel Helmy
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Box 167, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0QQ, UK
    Prog Neurobiol 95:352-72. 2011
    ..Ultimately, understanding the innate inflammatory response to traumatic brain injury may provide a therapeutic avenue in the treatment of central nervous system disease...
  8. pmc Detection of blast-related traumatic brain injury in U.S. military personnel
    Christine L Mac Donald
    Washington University School of Medicine, St Louis, MO 63110, USA
    N Engl J Med 364:2091-100. 2011
    Blast-related traumatic brain injuries have been common in the Iraq and Afghanistan wars, but fundamental questions about the nature of these injuries remain unanswered.
  9. pmc White matter damage and cognitive impairment after traumatic brain injury
    Kirsi Maria Kinnunen
    Department of Psychology, Goldsmiths, University of London, London, UK
    Brain 134:449-63. 2011
    ....
  10. doi Inflammation after trauma: microglial activation and traumatic brain injury
    Anil F Ramlackhansingh
    Centre for Neuroscience, Department of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK
    Ann Neurol 70:374-83. 2011
    ..In this study, we investigate whether an inflammatory response to TBI persists, and whether this response relates to structural brain abnormalities and cognitive function...
  11. pmc Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor
    Joana C d'Avila
    Dept of Neurology, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neuroinflammation 9:31. 2012
    ..Here we evaluated the efficacy of a PARP inhibitor, INO-1001, in suppressing microglial activation after cortical impact in the rat...
  12. pmc Repetitive closed-skull traumatic brain injury in mice causes persistent multifocal axonal injury and microglial reactivity
    Yoshitsugu Shitaka
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neuropathol Exp Neurol 70:551-67. 2011
    ..Thus, prominent and long-lasting abnormalities in this TBI model were underestimated using conventional approaches. The model may be useful for mechanistic investigations and preclinical assessment of candidate therapeutics...
  13. doi Changing patterns in the epidemiology of traumatic brain injury
    Bob Roozenbeek
    Department of Neurology, Erasmus MC, Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Nat Rev Neurol 9:231-6. 2013
    ..Taken together, these analyses identify a great need for standardized epidemiological monitoring in TBI...
  14. doi Moderate and severe traumatic brain injury in adults
    Andrew I R Maas
    Department of Neurosurgery, University Hospital Antwerp, Antwerp, Belgium
    Lancet Neurol 7:728-41. 2008
    ..Suggestions are provided for the way forward, with an emphasis on epidemiological monitoring, trauma organisation, and approaches to management...
  15. ncbi The impact of traumatic brain injuries: a global perspective
    Adnan A Hyder
    Department of International Health and Center for Injury Research and Policy, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    NeuroRehabilitation 22:341-53. 2007
    ..Greater resources for research and prioritized interventions are critical to promote evidence-based policy for TBI...
  16. ncbi A systematic review of brain injury epidemiology in Europe
    F Tagliaferri
    WHO Neurotrauma Collaborating Centre, M Bufalini Hospital, Cesena, Italy
    Acta Neurochir (Wien) 148:255-68; discussion 268. 2006
    ..Thus, we describe epidemiological factors from European studies largely published in the last 20 years...
  17. doi Traumatic brain injury screening: preliminary findings in a US Army Brigade Combat Team
    Heidi Terrio
    Department of Deployment Health, Evans Army Community Hospital, Fort Carson, Colorado 80913, USA
    J Head Trauma Rehabil 24:14-23. 2009
    ....
  18. doi The bright side of the glial scar in CNS repair
    Asya Rolls
    Asya Rolls, Ravid Shechter and Michal Schwartz are at the Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Nat Rev Neurosci 10:235-41. 2009
    ..However, increasing evidence suggests a beneficial role for this scar tissue as part of the endogenous local immune regulation and repair process. How can these opposing effects be reconciled? Perhaps it is all a matter of timing...
  19. doi Traumatic brain injury, shell shock, and posttraumatic stress disorder in the military--past, present, and future
    Sharon B Shively
    Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Head Trauma Rehabil 27:234-9. 2012
    ..Given current circumstance, we propose completing the work envisioned by Dr Mott almost 100 years ago...
  20. ncbi Mechanisms of early brain injury after subarachnoid hemorrhage
    Julian Cahill
    Department of Physiology, Loma Linda University Medical School, Loma Linda, California 92354, USA
    J Cereb Blood Flow Metab 26:1341-53. 2006
    ..It is imperative, therefore, to obtain a thorough understanding of the early events that occur after SAH, which will enable future therapies to be developed...
  21. ncbi The duality of the inflammatory response to traumatic brain injury
    P M Lenzlinger
    Department of Neurosurgery, University of Pennsylvania, Veterans Administration Medical Center, Philadelphia 19104-6316, USA
    Mol Neurobiol 24:169-81. 2001
    ..The implications of this duality of the post-traumatic inflammatory response for the treatment of brain-injured patients using anti-inflammatory strategies are discussed...
  22. ncbi Inflammatory response in acute traumatic brain injury: a double-edged sword
    Maria Cristina Morganti-Kossmann
    Department of Trauma Surgery, The Alfred Hospital, Prahran, Australia
    Curr Opin Crit Care 8:101-5. 2002
    ....
  23. doi Brain injuries from blast
    Cameron R Bass
    Department of Biomedical Engineering, Duke University, 136 Hudson Hall, Durham, NC 27708, USA
    Ann Biomed Eng 40:185-202. 2012
    ..of blast overpressure time histories, and there is strong experimental evidence in animal models that mild brain injuries occur at blast intensities that are similar to the pulmonary injury threshold...
  24. doi Traumatic brain injury: a disease process, not an event
    Brent E Masel
    Department of Neurology, Transitional Learning Center at Galveston, The Moody Center for Traumatic Brain and Spinal Cord Injury Research Mission Connect, The University of Texas Medical Branch, Galveston, Texas 77550, USA
    J Neurotrauma 27:1529-40. 2010
    ....
  25. ncbi Pathophysiology of traumatic brain injury
    C Werner
    Klinik fur Anasthesiologie, der Johannes Gutenberg Universität Mainz, Langenbeckstrasse 1, D 55131 Mainz, Germany
    Br J Anaesth 99:4-9. 2007
    ..Furthermore, excitotoxic cell damage and inflammation may lead to apoptotic and necrotic cell death. Understanding the multidimensional cascade of secondary brain injury offers differentiated therapeutic options...
  26. doi Blast-related mild traumatic brain injury: mechanisms of injury and impact on clinical care
    Gregory A Elder
    James J Peters Department of Veterans Affairs Medical Center, Rehabilitation Medicine Service, Bronx, NY, USA
    Mt Sinai J Med 76:111-8. 2009
    ..The high rates of mild traumatic brain injury and posttraumatic stress disorder in the current operations are of significant concern for the long-term health of US veterans with associated economic implications...
  27. pmc Cell death mechanisms and modulation in traumatic brain injury
    Bogdan A Stoica
    Shock, Trauma and Anesthesiology Research Center, National Study Center for Trauma and EMS, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    Neurotherapeutics 7:3-12. 2010
    ..Further, we underscore that the most effective neuroprotective strategies will need to target multiple pathways to reflect the regional and temporal changes underlying diverse neuronal cell death phenotypes...
  28. ncbi Long-term intracerebral inflammatory response after traumatic brain injury
    S M Gentleman
    Department of Neuropathology, Division of Neuroscience and Psychological Medicine, Imperial College London, Charing Cross Campus, London, UK
    Forensic Sci Int 146:97-104. 2004
    ..In support of this hypothesis we present evidence of persistent elevated microglial activity in long-term survivors of head injury and the suggestion of an association between the extent of this activity and interleukin-1 genotype...
  29. ncbi Traumatic brain injury and Alzheimer's disease: a review
    Corinna Van Den Heuvel
    Discipline of Pathology, University of Adelaide, Centre for Neurological Diseases, The Hanson Institute, Adelaide, Australia
    Prog Brain Res 161:303-16. 2007
    ..Furthermore, although it is known that APOE genotype plays an important role in AD, its link to a deleterious outcome following TBI remains inconclusive and ambiguous...
  30. doi Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury
    Jenna M Ziebell
    National Trauma Research Institute, The Alfred Hospital, Monash University, Melbourne, VIC 3181, Australia
    Neurotherapeutics 7:22-30. 2010
    ..This review addresses the role of several cytokines and chemokines following focal and diffuse TBI, as well as the controversies around the use of therapeutic anti-inflammatory treatments versus genetic deletion of cytokine expression...
  31. pmc Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies
    David J Loane
    Department of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research STAR, National Study Center for Trauma and Emergency Medical Systems, University of Maryland School of Medicine, Baltimore, MD, USA
    Trends Pharmacol Sci 31:596-604. 2010
    ..Here we critically review developing experimental neuroprotective strategies that show promise, and we propose criteria for improving the probability of successful clinical translation...
  32. ncbi The epidemiology of traumatic brain injury: a review
    John Bruns
    Sergievsky Center, College of Physicians and Surgeons, Department of Epidemiology, Joseph L Mailman School of Public Health, Columbia University, New York, New York, USA
    Epilepsia 44:2-10. 2003
    ..Traumatic brain injury (TBI) not only has considerable morbidity and mortality, but it is a major cause of epilepsy. We wish to determine the frequency of TBI, special groups at risk for TBI, and mortality from TBI...
  33. doi Default mode network functional and structural connectivity after traumatic brain injury
    David J Sharp
    The Hammersmith Hospital, London, W12 0NN, UK
    Brain 134:2233-47. 2011
    ..They can be explained by two related changes: a compensatory increase in functional connectivity within the default mode network; and a variable degree of structural disconnection that modulates this change in network function...
  34. pmc Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury
    David L Brody
    Department of Neurology, Hope Center for Neurological Disorders, Washington University, St Louis, Missouri, USA
    J Neurotrauma 24:657-73. 2007
    ..0 mm with 7-8 mice per group. Thus, the EM impactor and refined surgical and behavioral testing techniques may offer a reliable and convenient framework for preclinical TBI research involving mice...
  35. pmc Critical role of NADPH oxidase in neuronal oxidative damage and microglia activation following traumatic brain injury
    Quan Guang Zhang
    Department of Neurology, Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, Augusta, Georgia, United States of America
    PLoS ONE 7:e34504. 2012
    ..The current study thus addressed the potential role of NADPH oxidase in TBI...
  36. doi Traumatic brain injury: a risk factor for Alzheimer's disease
    Thamil Mani Sivanandam
    Biochemistry and Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Neurosci Biobehav Rev 36:1376-81. 2012
    ..This review focuses on AD related genes which are expressed during TBI and its relevance to progression of the disease. Such understanding will help to diagnose the risk of TBI patients to develop AD and design therapeutic interventions...
  37. pmc Antioxidant therapies in traumatic brain and spinal cord injury
    Mona Bains
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, Kentucky 40506, USA
    Biochim Biophys Acta 1822:675-84. 2012
    ..This article is part of a Special Issue entitled: Antioxidants and antioxidant treatment in disease...
  38. doi Salvianolic acid B attenuates brain damage and inflammation after traumatic brain injury in mice
    Tao Chen
    Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province 710032, People s Republic of China
    Brain Res Bull 84:163-8. 2011
    ..Thus SalB may have therapeutic potential for patients with TBI and perhaps other forms of acute brain injury...
  39. pmc The salutary effects of DHA dietary supplementation on cognition, neuroplasticity, and membrane homeostasis after brain trauma
    Aiguo Wu
    Department of Integrative Biology and Physiology, University of California at Los Angeles UCLA, Los Angeles, California 90095, USA
    J Neurotrauma 28:2113-22. 2011
    ..The overall results emphasize the potential of dietary DHA to counteract broad and fundamental aspects of TBI pathology that may translate into preserved cognitive capacity...
  40. pmc Widespread τ and amyloid-β pathology many years after a single traumatic brain injury in humans
    Victoria E Johnson
    Penn Center for Brain Injury and Repair and Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Brain Pathol 22:142-9. 2012
    ..This suggests that a single TBI induces long-term neuropathological changes akin to those found in neurodegenerative disease...
  41. doi Mechanisms of blast induced brain injuries, experimental studies in rats
    M Risling
    Department of Neuroscience, Karolinska Institutet, Stockholm S 171 77, Sweden
    Neuroimage 54:S89-97. 2011
    Traumatic brain injuries (TBI) potentially induced by blast waves from detonations result in significant diagnostic problems. It may be assumed that several mechanisms contribute to the injury...
  42. pmc Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- mice
    Bridgette D Semple
    National Trauma Research Institute, Alfred Hospital, Melbourne, Victoria, Australia
    J Cereb Blood Flow Metab 30:769-82. 2010
    ..Our findings confirm the significant role of CCL2 in mediating post-traumatic secondary brain damage...
  43. doi Therapeutic evaluation of etanercept in a model of traumatic brain injury
    Chung Ching Chio
    Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan
    J Neurochem 115:921-9. 2010
    ..These findings suggest that etanercept may improve outcomes of TBI by penetrating into the cerebrospinal fluid in rats...
  44. pmc Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease?
    Victoria E Johnson
    Brain Injury and Repair, Departmentof Neurosurgery, University of Pennsylvania School of Medicine, 3320 Smith Walk, Hayden Hall 105, Philadelphia, Pennsylvania 19104, USA University of Glasgow, University Avenue, Glasgow G12 8QQ, UK
    Nat Rev Neurosci 11:361-70. 2010
    ....
  45. doi Genetic and histologic evidence implicates role of inflammation in traumatic brain injury-induced apoptosis in the rat cerebral cortex following moderate fluid percussion injury
    H Shojo
    Department of Legal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
    Neuroscience 171:1273-82. 2010
    ..Therapies designed at abrogating apoptosis and/or inflammation may prove effective when initiated at this subacute TBI phase...
  46. ncbi Modulation of immune response by head injury
    Maria Cristina Morganti-Kossmann
    Department of Trauma Surgery, The Alfred Hospital, Monash University, Commercial Road, Melbourne, VIC 3004, Australia
    Injury 38:1392-400. 2007
    ..This review article discusses the notion that the inflammatory response to TBI is no longer a peripherally mediated phenomenon, and that the CNS significantly influences the immunological sequence of events in the aftermath of injury...
  47. pmc Calpain as a therapeutic target in traumatic brain injury
    Kathryn E Saatman
    Spinal Cord and Brain Injury Research Center, Department of Physiology, University of Kentucky, Lexington, Kentucky 40536 0509, USA
    Neurotherapeutics 7:31-42. 2010
    ..This review focuses on the current state of knowledge of the role of calpains in TBI-induced neuropathology and effectiveness of calpain as a therapeutic target in the acute post-traumatic period...
  48. ncbi Time course of cellular pathology after controlled cortical impact injury
    S Chen
    Academic Neurosurgery, Centre for Brain Repair, University of Cambridge, Cambridge, UK
    Exp Neurol 182:87-102. 2003
    ..We discuss these results in light of recent evidence that suggests there may be some degree of endogenous repair after central nervous system injury...
  49. doi The retrospective application of a prediction model to patients who have had a decompressive craniectomy for trauma
    Stephen Honeybul
    Department of Neurosurgery, Sir Charles Gairdner Hospital and Royal Perth Hospital, Perth, Western Australia, Australia
    J Neurotrauma 26:2179-83. 2009
    ..Statistical analysis of the outcomes in our cohort confirmed that the CRASH model reliably predicted unfavorable outcome. This study demonstrated that our ability to predict poor outcome has improved...
  50. pmc The role of the choroid plexus in neutrophil invasion after traumatic brain injury
    Joanna Szmydynger-Chodobska
    Department of Emergency Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Cereb Blood Flow Metab 29:1503-16. 2009
    ..This is the first detailed analysis of the BCSFB function related to neutrophil trafficking. Our observations support the role of this barrier in posttraumatic neutrophil invasion...
  51. ncbi Surveillance for traumatic brain injury-related deaths--United States, 1997-2007
    Victor G Coronado
    Division of Injury Response, National Center for Injury Prevention and Control, CDC, Atlanta, Georgia 30341, USA
    MMWR Surveill Summ 60:1-32. 2011
    ..During 1989-1998, TBI-related death rates decreased 11.4%, from 21.9 to 19.4 per 100,000 population. This report describes the epidemiology and annual rates of TBI-related deaths during 1997-2007...
  52. doi The psychiatric sequelae of traumatic injury
    Richard A Bryant
    School of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia
    Am J Psychiatry 167:312-20. 2010
    ..The authors sought to determine the range of new psychiatric disorders occurring after traumatic injury and the influence of mild TBI on psychiatric status...
  53. doi GFAP and S100B are biomarkers of traumatic brain injury: an observational cohort study
    P E Vos
    Departments of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neurology 75:1786-93. 2010
    ..This study aims to validate glial fibrillary acidic protein (GFAP) and S100B concentrations in blood as outcome predictors of TBI using cutoff levels of 1.5 μg/L for GFAP and 1.13 μg/L for S100B from a previous study...
  54. ncbi Military TBI during the Iraq and Afghanistan wars
    Deborah Warden
    Defense and Veterans Brain Injury Center, Walter Reed Army Medical Center, Washington, DC 20307, USA
    J Head Trauma Rehabil 21:398-402. 2006
    ..Although penetrating brain injuries are more readily identified, closed brain injuries occur more commonly...
  55. ncbi Progressive damage after brain and spinal cord injury: pathomechanisms and treatment strategies
    Helen M Bramlett
    Department of Neurological Surgery, Neurotrauma Research Center, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136, USA
    Prog Brain Res 161:125-41. 2007
    ..This chapter summarizes some of the recent data regarding progressive damage after CNS trauma and mechanisms underlying these changes...
  56. ncbi Edema and brain trauma
    A W Unterberg
    Department of Neurosurgery, Ruprecht Karls University of Heidelberg, Im Neuenheimer Feld 400, D 69120 Heidelberg, Germany
    Neuroscience 129:1021-9. 2004
    ..These findings suggest that cytotoxic and vasogenic brain edema are two entities which can be targeted simultaneously or according to their temporal prevalence...
  57. pmc Forebrain neurogenesis after focal Ischemic and traumatic brain injury
    Steven G Kernie
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
    Neurobiol Dis 37:267-74. 2010
    ..Future therapies should be aimed at directing appropriate neuronal replacement after ischemic or traumatic injury while suppressing aberrant integration that may contribute to co-morbidities such as epilepsy or cognitive impairment...
  58. pmc Clinical trials in head injury
    Raj K Narayan
    Department of Neurosurgery, Temple University Hospital, Philadelphia, Pennsylvania 19140, USA
    J Neurotrauma 19:503-57. 2002
    ..This paper is an attempt to summarize the key points made at the workshop. It is hoped that these lessons will enhance the planning and design of future efforts in this important field of research...
  59. doi Toll-like receptors in inflammation of the central nervous system
    Yan Kong
    Department of Biochemistry and Molecular Biology, Medical School, Southeast University, Nanjing 210009, China
    Int Immunopharmacol 11:1407-14. 2011
    ....
  60. doi Severity of controlled cortical impact traumatic brain injury in rats and mice dictates degree of behavioral deficits
    SeongJin Yu
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Brain Res 1287:157-63. 2009
    ....
  61. pmc Predicting outcome after traumatic brain injury: practical prognostic models based on large cohort of international patients
    Pablo Perel
    London School of Hygiene and Tropical Medicine, London WC1B 3DP
    BMJ 336:425-9. 2008
    ..To develop and validate practical prognostic models for death at 14 days and for death or severe disability six months after traumatic brain injury...
  62. pmc Animal modelling of traumatic brain injury in preclinical drug development: where do we go from here?
    Niklas Marklund
    Department of Neuroscience, Neurosurgery, Uppsala University, Uppsala University Hospital, Uppsala, Sweden
    Br J Pharmacol 164:1207-29. 2011
    ....
  63. ncbi Update of neuropathology and neurological recovery after traumatic brain injury
    John T Povlishock
    Department of Anatomy and Neurobiology, Medical College of Virginia Campus of Virginia Commonwealth University, 1101 East Marshall St, PO Box 980709, Richmond, VA 23298, USA
    J Head Trauma Rehabil 20:76-94. 2005
    ....
  64. pmc Long-term upregulation of inflammation and suppression of cell proliferation in the brain of adult rats exposed to traumatic brain injury using the controlled cortical impact model
    Sandra A Acosta
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 8:e53376. 2013
    ..Therapeutic intervention at the chronic stage of TBI may confer abrogation of these deleterious cell death processes...
  65. doi Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT)
    Ross D Zafonte
    Department of Physical Medicine and Rehabilitation, Harvard Medical School, and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    JAMA 308:1993-2000. 2012
    ..Approved for use in TBI in 59 countries, citicoline is an endogenous substance offering potential neuroprotective properties as well as facilitated neurorepair post injury...
  66. ncbi Incidence of traumatic brain injury in the United States, 2003
    Wesley Rutland-Brown
    Centers for Disease Control and Prevention, National Center for Injury Prevention and Control, Division of Injury Response, Atlanta, GA 30341, USA
    J Head Trauma Rehabil 21:544-8. 2006
    ..Findings were similar to those from previous years in which rates of TBI were highest for young children (aged 0-4) and men, and the leading causes of TBI were falls and motor vehicle traffic...
  67. doi The stem cell potential of glia: lessons from reactive gliosis
    Stefanie Robel
    Physiological Genomics, Ludwig Maximilians University of Munich, Germany
    Nat Rev Neurosci 12:88-104. 2011
    ..This new view on reactive glia therefore suggests a widespread endogenous source of cells with stem cell potential, which might potentially be harnessed for local repair strategies...
  68. doi Brain injury risk from primary blast
    Karin A Rafaels
    Army Research Laboratory, 328 Hopkins Rd, ATTN RDRL SLB W, Aberdeen Proving Ground, MD 21005, USA
    J Trauma Acute Care Surg 73:895-901. 2012
    ..However, there is little information on the intensity and duration of blast necessary to cause brain injury...
  69. doi Decompressive craniectomy in diffuse traumatic brain injury
    D James Cooper
    Department of Intensive Care, Alfred Hospital, Commercial Road, Melbourne, VIC 3004, Australia
    N Engl J Med 364:1493-502. 2011
    ..It is unclear whether decompressive craniectomy improves the functional outcome in patients with severe traumatic brain injury and refractory raised intracranial pressure...
  70. pmc Traumatic brain injury: an overview of pathobiology with emphasis on military populations
    Ibolja Cernak
    National Security Technology Department, Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland 20723, USA
    J Cereb Blood Flow Metab 30:255-66. 2010
    ..These brain injuries are characterized by primary damage to both gray and white matter and subsequent evolution of secondary ..
  71. doi In vitro models of traumatic brain injury
    Barclay Morrison
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Annu Rev Biomed Eng 13:91-126. 2011
    ..We conclude that in vitro models were greater than 88% predictive of in vivo results...
  72. ncbi Dual role of tumor necrosis factor alpha in brain injury
    E Shohami
    Department of Pharmacology, Hebrew University School of Pharmacy, Jerusalem, Israel
    Cytokine Growth Factor Rev 10:119-30. 1999
    ..It is suggested that the appropriate context of mediators, at any given time after brain injury may well determine whether the effect of TNF alpha is protective or toxic...
  73. ncbi Traumatic brain injury in the war zone
    Susan Okie
    N Engl J Med 352:2043-7. 2005
  74. doi Attenuated neurological deficit, cell death and lesion volume in Fas-mutant mice is associated with altered neuroinflammation following traumatic brain injury
    Jenna M Ziebell
    National Trauma Research Institute, Alfred Hospital, Melbourne, Australia
    Brain Res 1414:94-105. 2011
    ..In future studies, the lpr mouse strain may be utilized as a model to further characterize molecular and cellular mechanisms protecting against secondary brain damage after TBI...
  75. ncbi Astrocytes and brain injury
    Yongmei Chen
    Department of Neurology, University of California at San Francisco, California 94121, USA
    J Cereb Blood Flow Metab 23:137-49. 2003
    ..In addition, the death or survival of astrocytes themselves may affect the ultimate clinical outcome and rehabilitation through effects on neurogenesis and synaptic reorganization...
  76. doi Evidence-based cognitive rehabilitation: updated review of the literature from 2003 through 2008
    Keith D Cicerone
    Department of Physical Medicine and Rehabilitation, JFK Johnson Rehabilitation Institute, Edison, NJ 08820, USA
    Arch Phys Med Rehabil 92:519-30. 2011
    ..To update our clinical recommendations for cognitive rehabilitation of people with traumatic brain injury (TBI) and stroke, based on a systematic review of the literature from 2003 through 2008...
  77. pmc Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury
    Jonas J Gopez
    Department of Neurosurgery, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Neurosurgery 56:590-604. 2005
    ..A growing literature supports the benefit of COX2-specific inhibitors in treating brain injuries.
  78. pmc The cytokine response to human traumatic brain injury: temporal profiles and evidence for cerebral parenchymal production
    Adel Helmy
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Cereb Blood Flow Metab 31:658-70. 2011
    ..No clear arterio-jugular venous gradients were apparent. These data provide evidence for the cerebral production of these cytokines and show a stereotyped temporal pattern after TBI...
  79. pmc Transient blockage of the CD11d/CD18 integrin reduces contusion volume and macrophage infiltration after traumatic brain injury in rats
    Akira Utagawa
    Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Brain Res 1207:155-63. 2008
    ..These data emphasize the beneficial effects of blocking inflammatory cell recruitment into the injured brain on histopathological outcome following traumatic brain injury...
  80. doi Astrocytes in the damaged brain: molecular and cellular insights into their reactive response and healing potential
    Annalisa Buffo
    Department of Neuroscience, University of Turin, Neuroscience Institute of Turin, Italy
    Biochem Pharmacol 79:77-89. 2010
    ..Moreover, the cellular/molecular mechanisms supporting the detrimental or beneficial features of astrogliosis have been scrutinized to gain insights on possible pharmacological approaches to enhance astrocyte neuroprotective activities...
  81. ncbi Diffuse axonal injury in mild traumatic brain injury: a diffusion tensor imaging study
    Matilde Inglese
    Department of Radiology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosurg 103:298-303. 2005
    ..Although DAI is frequently underdiagnosed by conventional imaging modalities, it can be demonstrated using diffusion tensor imaging. The aim of this study was to assess the presence and extent of DAI in patients with mild TBI...
  82. ncbi Notch signaling in astrocytes and neuroblasts of the adult subventricular zone in health and after cortical injury
    Maria I Givogri
    Laboratory for Gene Therapy of Neurodegenerative Disorders, San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
    Dev Neurosci 28:81-91. 2006
    ..Finally, using a model of cortical stab wound, we show that the astrogliogenic response of the SVZ to injury is accompanied by activation of the Notch pathway...
  83. ncbi 'Oops!': performance correlates of everyday attentional failures in traumatic brain injured and normal subjects
    I H Robertson
    Applied Psychology Unit, Rehabilitation Research Group, Addenbrooke s Hospital, Cambridge, U K
    Neuropsychologia 35:747-58. 1997
    ..We also report a highly significant correlation of -0.58 between SART performance and Glasgow Coma Scale Scores in the TBI group...
  84. pmc Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury
    Dan Shlosberg
    Department of Physiology and Neurobiology, Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Nat Rev Neurol 6:393-403. 2010
    ..Finally, we highlight areas for future basic research and clinical studies into TBI...
  85. ncbi The plastic human brain cortex
    Alvaro Pascual-Leone
    Center for Non Invasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Annu Rev Neurosci 28:377-401. 2005
    ..The challenge we face is to learn enough about the mechanisms of plasticity to modulate them to achieve the best behavioral outcome for a given subject...
  86. pmc MRI evaluation of axonal reorganization after bone marrow stromal cell treatment of traumatic brain injury
    Quan Jiang
    Department of Neurology, Henry Ford Health System, Detroit, MI 48202, USA
    NMR Biomed 24:1119-28. 2011
    ..Our data demonstrate that AKC, FA, FT and T(2) can be used to evaluate treatment-induced white matter recovery, which may facilitate restorative therapy in patients with TBI...
  87. pmc Metamorphosis of subarachnoid hemorrhage research: from delayed vasospasm to early brain injury
    Fatima A Sehba
    Department of Neurosurgery, Mount Sinai School of Medicine, Box 1136, New York, NY 10029, USA
    Mol Neurobiol 43:27-40. 2011
    ..This manuscript reviews the pathological mechanisms of early brain injury after SAH and summarizes the status of current therapies...
  88. ncbi Astrocyte intermediate filaments in CNS pathologies and regeneration
    Milos Pekny
    Department of Medical Biochemistry, Sahlgrenska Academy at Goteborg University, Box 430, 405 30 Goteborg, Sweden
    J Pathol 204:428-37. 2004
    ..GFAP is the principal astrocyte intermediate filament protein and dominant mutations in the GFAP gene have been shown to lead to Alexander disease, a fatal neurodegenerative condition in humans...
  89. doi Default mode network connectivity predicts sustained attention deficits after traumatic brain injury
    Valerie Bonnelle
    The Computational, Cognitive and Clinical Neuroimaging Laboratory, Centre for Neuroscience, Division of Experimental Medicine and The Medical Research Council Clinical Sciences Centre, Imperial College London, London W120NN, United Kingdom
    J Neurosci 31:13442-51. 2011
    ..These results show that abnormalities in DMN function are a sensitive marker of impairments of attention and suggest that changes in connectivity within the DMN are central to the development of attentional impairment after TBI...
  90. ncbi The JFK Coma Recovery Scale-Revised: measurement characteristics and diagnostic utility
    Joseph T Giacino
    JFK Johnson Rehabilitation Institute and New Jersey Neuroscience Institute, JFK Medical Center, Edison, NJ 08820, USA
    Arch Phys Med Rehabil 85:2020-9. 2004
    ..To determine the measurement properties and diagnostic utility of the JFK Coma Recovery Scale-Revised (CRS-R)...
  91. ncbi Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant
    E Shohami
    Department of Pharmacology, Hebrew University, School of Pharmacy, Jerusalem, Israel
    J Neuroimmunol 72:169-77. 1997
    ..TNF-alpha modulating agents, if given within the early time window post-injury, may improve the final neurological outcome in victims of brain trauma...
  92. doi The epidemiology of traumatic brain injury
    John D Corrigan
    Department of Physical Medicine and Rehabilitation, Ohio State University, Columbus, OH 43210, USA
    J Head Trauma Rehabil 25:72-80. 2010
    ..To describe the most recent estimates of the incidence and prevalence of traumatic brain injury (TBI) and review current issues related to measurement and use of these data...
  93. doi Diffusion tensor imaging of mild to moderate blast-related traumatic brain injury and its sequelae
    Harvey S Levin
    Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurotrauma 27:683-94. 2010
    ..Our data do not show WM injury in mild to moderate blast-related TBI in veterans despite their residual symptoms and difficulty in verbal memory. Limitations of the study and implications for future research are also discussed...
  94. ncbi Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?
    Chrysanthy Ikonomidou
    Department of Pediatric Neurology, Children s Hospital, Charité Virchow Campus, Humboldt University, Berlin, Germany
    Lancet Neurol 1:383-6. 2002
    ..We propose that NMDA receptor antagonists failed stroke and traumatic brain injury trials in human beings because blockade of synaptic transmission mediated by NMDA receptors hinders neuronal survival...
  95. pmc Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury
    Georgene W Hergenroeder
    The Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas, USA
    J Neuroinflammation 7:19. 2010
    ..While pressure catheters can be implanted to monitor ICP, there is no clinically proven method for determining a patient's risk for developing this pathology...
  96. doi Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery
    Adel Helmy
    Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Neurotrauma 26:549-61. 2009
    ..This study is the first to systematically determine relative recovery in vitro for a wide range of cytokines. The two forms of perfusion fluid require direct comparison in vivo...
  97. pmc Complement in the brain
    Robert Veerhuis
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Mol Immunol 48:1592-603. 2011
    ....
  98. doi Mechanisms of cerebral edema in traumatic brain injury: therapeutic developments
    James J Donkin
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver BC, Canada
    Curr Opin Neurol 23:293-9. 2010
    ..The present review summarizes the most recent advances in the understanding of mechanisms associated with development of posttraumatic cerebral edema, and highlights areas of therapeutic promise...
  99. ncbi Guidelines for the management of severe traumatic brain injury. I. Blood pressure and oxygenation
    Susan L Bratton
    J Neurotrauma 24:S7-13. 2007
  100. ncbi Interleukin-6 promotes post-traumatic healing in the central nervous system
    K R Swartz
    Department of Neurological Surgery, University of Wisconsin, Madison 53706, USA
    Brain Res 896:86-95. 2001
    ..IL-6-deficient (C57Bl/6J-IL-6-/-) mice to study the consequences of the absence of IL-6 on the pathology of brain injuries. We monitored the immediate, early, and late responses to this traumatic injury by characterizing several ..
  101. ncbi Essential protective roles of reactive astrocytes in traumatic brain injury
    D J Myer
    Department of Neurobiology, University of California Los Angeles, CA 90095 1763, USA
    Brain 129:2761-72. 2006
    ..These findings indicate that the reactive astrocytes play essential roles in preserving neural tissue and restricting inflammation after moderate focal brain injury...

Research Grants74

  1. Principles of Therapy in Cerebellar Disease: Explorations in Ion Channel Mutants
    JOHN SAMUEL STAHL; Fiscal Year: 2013
    ..Such patients are common in the veteran population and becoming more so due to traumatic brain injuries suffered in recent military operations...
  2. Pituitary dysfunction, behavioral symptoms, and quality of life after blast mTBI
    CHARLES WILLIAM WILKINSON; Fiscal Year: 2012
    ..Although termed "mild" in comparison to brain injuries resulting in death, coma, or paralysis, mTBI, particularly repetitive mTBI characteristic of soldiers deployed ..
  3. PARP inhibitor and Redox Catalyst Conjugate for Traumatic Brain Injury
    Kanneganti Murthy; Fiscal Year: 2012
    ..We are developing a novel drug that targets the basic mechanisms of this condition and will test this agent in a clinically-relevant animal model. ..
  4. Prostaglandin signaling following seizures
    Jianxiong Jiang; Fiscal Year: 2013
    ..be an independent and successful scientist dedicated to understanding the cellular and molecular mechanisms of brain injuries, and ultimately developing novel therapeutic strategies...
  5. Chondroitin Sulfate Proteoglycan and Myelination in Intraventricular Hemorrhage
    Praveen Ballabh; Fiscal Year: 2010
    ..important components of the extracellular matrix (ECM) and are increased in adult and neonatal brain injuries. They are primarily produced by reactive astrocytes and are regulated by transforming growth factor-2 (TGF-2) ..
  6. Age-dependent microglial responses in hypoxia-ischemia
    PETER A FERRAZZANO; Fiscal Year: 2013
    ..Disabilities research is the ideal environment for conducting translational research in developmental brain injuries. The Waisman Center houses the labs of my Mentors and other experts in developmental brain injuries and ..
  7. Clinical and Molecular Biology of Acute and Chronic Traumatic Encephalopathies
    JAMES WAVELL AIKEN; Fiscal Year: 2011
    ....
  8. Regulated Hypothermia to Treat Hypoxic-Ischemic Brain Injury
    Laurence M Katz; Fiscal Year: 2010
    ..are to optimize hypothermia and rewarming to improve neurological outcome from a broad range of ischemic brain injuries. PUBLIC HEALTH RELEVANCE: Drug-induced lowering of body temperature is proposed as a simple, effective new ..
  9. Physiological Disturbances Associated with Neonatal Intraventricular Hemorrhage
    JEFFREY RADIN KAISER; Fiscal Year: 2012
    ..order to predict those infants most at risk and to develop best care clinical practices that may limit severe brain injuries. While the etiology of IVH is multifactorial, disturbances of cerebral autoregulation play an important role...
  10. A Mouse Model for Emotional Disorder Caused by Mild Traumatic Brain Injury
    ANTON J REINER; Fiscal Year: 2013
    ....
  11. Mechanisms Underlying Tauopathy Following Traumatic Brain Injury
    David Brody; Fiscal Year: 2013
    ..The worldwide interest in athletes and military personnel with tau pathology and chronic traumatic encephalopathy underscores the urgency of this line of investigation. ..
  12. Zn2+, mitochondria and the induction of ischemic neurodegeneration
    John H Weiss; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ischemic brain injuries are leading causes of morbidity and mortality to the aging population, but current therapy is poor in part because of our limited understanding of pathogenic mechanisms leading ..
  13. Biomarkers of Vasospasm and Outcome following Subarachnoid Hemorrhage
    Sherry Hsiang Yi Chou; Fiscal Year: 2013
    ..study will advance our understanding on important molecular mechanisms that lead to vasospasm and to secondary brain injuries in SAH...
  14. A MICRO-ELECTRODE STUDY OF OXYGEN-BASED FUNCTIONAL CONNECTIVITY
    Lawrence H Snyder; Fiscal Year: 2012
    ..aspects of behavioral performance can be predicted by the ongoing level of slow correlated BOLD fluctuations;brain injuries perturb resting state networks;and multiple clinical disorders, including depression, dyslexia and ..
  15. Sleep and Brain Structure in Heart Failure
    MARY ANN WOO; Fiscal Year: 2012
    ..in brain structure in HF, and whether oxygenation/reperfusion processes accompanying apnea could lead to brain injuries in the syndrome...
  16. BIOMECHANICS OF BRAIN EDEMA AND INTRACRANIAL PRESSURE
    CHRISTINA ROSE MARMAROU; Fiscal Year: 2012
    ..This proposal will address the fundamental mechanism of brain swelling and how it can be blocked pharmacologically. ..
  17. Group I Metabotropic Glutamate Receptors and Epileptogenesis
    Paul A Rutecki; Fiscal Year: 2013
    ..hippocampus, an area of the brain involved with memory formation, is susceptible to develop epilepsy following brain injuries. Recent findings of the role of traumatic brain injury and mild concussive injury in the development of post-..
  18. Regulation of Calcium Signaling in Retinal Ganglion Cells after Nerve Injury
    Nicholas C Brecha; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ocular and traumatic brain injuries (TBI) from blunt trauma or blast injury to the head occur with high frequency on the battlefield, and they are often accompanied by multiple visual dysfunctions, ..
  19. Mechanisms of Hyperbaric Oxygen Induced Brain Protection
    John H Zhang; Fiscal Year: 2013
    ..For broadening of clinical applicability, it was also designed to evaluate efficacy of HBO-PC against other brain injuries by using a global cerebral ischemia model produced by Four Vessel Occlusion (4VO);and a Surgical Brain Injury (..
  20. CENTRAL THALAMIC DEEP BRAIN STIMULATION MODELS
    Nicholas D Schiff; Fiscal Year: 2013
    ..atlas will assist in the construction of a human atlas that could be used in the treatment of non-progressive brain injuries. Thus, the long-range goal of this work is to optimize neuromodulation strategies employing electrical ..
  21. Novel up-regulators of NF-kB activity: effect on MnSOD and TBI in vitro models
    Maurizio Grimaldi; Fiscal Year: 2012
    ..molecules could be relevant for future drug development which could benefit not only patients with traumatic brain injuries but also patients with ROS damage-associated neurodegenerative diseases...
  22. TGF-beta Mediated Inflammatory Signaling: a Critical Role in Epileptogenesis
    Daniela Kaufer; Fiscal Year: 2012
    ..Traumatic, ischemic, or infectious brain injuries are often associated with vascular injuries, specifically with opening of the blood-brain barrier (BBB)...
  23. Gestural Interfaces and Robotics for Rehabilitation
    CORINNA E LATHAN; Fiscal Year: 2010
    ..children has been estimated by the CDC as 90 per 100,000 resulting in the addition of 60,000 children with new brain injuries annually...
  24. Identification of Persistent Impairments in Postural Control Following Concussion
    GEORGE W SHAVER; Fiscal Year: 2011
    ....
  25. The Importance of Temperature on Inflammation after TBI
    W Dalton Dietrich; Fiscal Year: 2013
    ..The proposed studies will provide novel information regarding the development of seizures after TBI and determine how hypothermia therapy may improve this debilitating consequence of TBI. ..
  26. Health and Biomedical Science for a Diverse Community, Phase II
    Bertram Lubin; Fiscal Year: 2009
    ..The topics are: Fourth Grade: Unit 1: Nutrition: Balance and Imbalance (Obesity);Unit 2. Traumatic Brain Injuries;Unit 3. Infectious Diseases and Immunity;Unit 4. Environmental Toxics: Poisoning Prevention...
  27. p75NTR Ligands for Treament of Traumatic Brain Injury
    Stephen M Massa; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Project Summary: Traumatic brain injuries (TBIs) constitute a significant and growing percentage of injuries in the veteran population;sequelae of explosions, motor vehicle accidents and falls...
  28. Central Auditory Processing Deficits Associated with Blast Exposure
    Marjorie R Leek; Fiscal Year: 2012
    ..injuries and 28%-31% of those evacuated to Walter Reed Army Medical Center (WRAMC), Washington, DC had brain injuries. While the common focus of auditory evaluation is on damage to the peripheral auditory system, the prevalence ..
  29. Blood-Brain Barrier Disruption in Blast Neurotrauma
    AMANDA DAWN GAUDREAU-BALDERRAMA; Fiscal Year: 2013
    ..Insights gained from this work will stimulate further development of MIMS technology for biomedical research and accelerate translational development of urgently needed diagnostics and therapeutics for blast-related TBI and CTE. ..
  30. Treatment of Status Epilepticus: A Translational Proposal
    Claude G Wasterlain; Fiscal Year: 2013
    ..Proposal Epilepsy is the most common diagnosis in VA outpatient clinics, and the large number of traumatic brain injuries in OEF/OIF is expected to result in a significant increase in its frequency among veterans...
  31. A Novel Method to Improve Proliferation and Neural Induction of Human MSCs
    Bradley H Garcia; Fiscal Year: 2012
    ..therapeutic promise of human mesenchymal stem cells (hMSCs) for neurodegenerative diseases, spinal cord and brain injuries, cardiovascular diseases, diabetes mellitus, and diseases of the skeleton...
  32. Role of beta catenin mediated neural stem cell and astrocyte proliferation in TBI
    Diana M Sama; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Approximately 1.5 million traumatic brain injuries (TBIs) occur in the United States annually...
  33. Frontal Lobe Neuroimaging as a Biomarker of Chronic Traumatic Encephalopathy
    JULIE MARIE STAMM; Fiscal Year: 2012
    ..This study is part of a larger study, which is the first to address these issues and, therefore, may have a considerable impact on public health. ..
  34. The Effects of Ketogenic Diets on Inflammation and Chronic Pain
    DAVID NATHANIEL RUSKIN; Fiscal Year: 2010
    ..epilepsy and demonstrated basic research potential for neuroprotection in several types of acute and chronic brain injuries. A number of biochemical consequences of a ketogenic diet - decreased reactive oxygen species, decreased ..
  35. Chronic Traumatic Encephalopathy: Clinical Presentation and Biomarkers
    Robert A Stern; Fiscal Year: 2013
    ..abstract_text> ..
  36. Development of Thermoacoustic Tomography Brain Imaging
    Mark A Anastasio; Fiscal Year: 2013
    ..will yield a powerful and effective new modality for monitoring brain conditions such as strokes, tumors, and brain injuries. Its specific advantages over existing high-resolution human brain imaging modalities include 1) relatively ..
  37. Molecular mechanisms of adult neurogenesis following traumatic brain injury
    MICHELLE LEE THEUS; Fiscal Year: 2010
    Approximately 1.4 million Americans sustain traumatic brain injuries (TBI) each year resulting in death or long-term disability. The use of stem cells to repair or replace damaged brain tissue is a new and exciting avenue of research...
  38. Mouthpiece for mTBI Detection during Adolescent Contact and Collision Sports
    PAUL L GIBSON; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): There are approximately 300,000 sports related traumatic brain injuries every year resulting in loss of consciousness...
  39. Compensatory regulation of energy balance by neurogenesis in adult hypothalamus
    Allison W Xu; Fiscal Year: 2013
    ..It will provide novel insight into therapeutic potential of neural stem cells in treatment of hypothalamic neurodegeneration that are associated with a variety of chronic diseases and brain injuries.
  40. exRNA signatures Predict Outcomes after brain injury
    Robert Spetzler; Fiscal Year: 2013
    ..Given the predictable temporal course of these brain injuries, they are ideal candidates for biomarker identification...
  41. fMRI and DTI in Children with PVH/PVL
    Heidi M Feldman; Fiscal Year: 2010
    ..It will also contribute to understanding the impact of white matter injury and the development of cortical plasticity after early brain injuries.
  42. The Role of Monocytes and Microglia in Traumatic Brain Injury-Induced Tauopathies
    Richard M Ransohoff; Fiscal Year: 2013
    ..2. Determine the role of infiltrating monocytes in TBI Induced MAPT pathologies in hTau mice. ..
  43. Regulation of the Unfolded Protein Response after Acute Brain Injury
    James D Lechleiter; Fiscal Year: 2013
    ..Current therapeutic strategies to combat acute brain injuries have been largely unsuccessful...
  44. Role of calpastatin in modulating function following TBI
    Kathryn E Saatman; Fiscal Year: 2011
    ..abstract_text> ..
  45. Fluid Therapy and Cerebral Injury in Pediatric Diabetic Ketoacidosis
    Nathan Kuppermann; Fiscal Year: 2013
    ..and recent data indicates that even children who survive DKA apparently without complications may have subtle brain injuries which may result in learning and memory problems...
  46. Targeting Muller Cells to Treat Optic Nerve Injury
    Sherry Ball; Fiscal Year: 2009
    ..Ball, PhD Objectives: A substantial proportion of returning veterans diagnosed with traumatic brain injuries (TBI) also exhibit visual deficits...
  47. Mechanism of Brain-Specific Angiogenesis Inhibitor 1 (BAI1) in Neural Development
    Joseph G Duman; Fiscal Year: 2013
    ..These defects also contribute to the pathologies of mental diseases, neurodegenerative diseases, and traumatic brain injuries. Determination of the signaling mechanisms that direct dendrite and spine formation should unveil new ..
  48. Affordable Adolescent Athletic Mild Traumatic Brain Injury Risk Management System
    DANIEL S HEDIN; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Some 1.6 to 3.8 million mild traumatic brain injuries occur annually in the United States as a result of recreational activities...
  49. Effects of Gangliosides on Neural Stem Cells: Role in Neuroregeneration
    Robert K Yu; Fiscal Year: 2013
    ..and that it may play important roles not only in learning and memory, but also in functional recovery from brain injuries. This latter observation also points to the fact that impairment of NSCs and/or neural precursor cells (NPCs) ..
  50. Functional reorganization of limbic circuitry after TBI
    M Grady; Fiscal Year: 2009
    ..The compensatory mechanisms demonstrated in the contralateral hippocampus may help us better understand cognitive recovery in human TBI and lead to novel strategies for improving speed and extent of recovery. ..
  51. Derivation of human pluripotent stem cells using small molecules
    Yanhong Shi; Fiscal Year: 2010
    ..These genetically unmodified iPS cells will be applicable in stem cell-based cell replacement therapies for the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, and brain injuries.
  52. The Neural Organization of Tool Use Actions in Humans
    Scott H Frey; Fiscal Year: 2010
    ..involve the skillful use of manual tools and utensils. Thus, the consequences of brain injuries or diseases that compromise these behaviors are often devastating...
  53. NMDA Receptor Dynamics After Brain Injury
    Anat Biegon; Fiscal Year: 2011
    ..Attempts to treat accidental brain injuries with glutamate NMDA receptor (NMDAR) antagonists have failed to...
  54. The National Neurotrauma Society 30th Annual Conference (Phoenix July 22-25,2012)
    KEVIN KA WANG WANG; Fiscal Year: 2012
    ..In addition, approximately 12,000 new spinal cord injuries occur each year. The theme of this year's conference is "The Spectrum of Neurotrauma". ..
  55. Immunomodulatory Hydrogels for Stem Cell Therapy after TBI
    Ravi V Bellamkonda; Fiscal Year: 2013
    ..7 million Americans suffer traumatic brain injuries, half a million of whom are children...
  56. PRECLINICAL CYCLOSPORIN A THERAPY TRIALS FOR PEDIATRIC TBI
    SUSAN SHEPS MARGULIES; Fiscal Year: 2012
    ..This state-of-the-art, innovative preclinical study design can be applied to future evaluations of other therapies longer treatment windows, other ages, other brain injuries, and to other agents that promote neurorecovery or repair.
  57. EEG synchrony of preterm infants: Regional disparities and perinatal risks
    Philip Grieve; Fiscal Year: 2009
    ..weight premature infants are at risk for adverse neurodevelopmental outcome even when there are no apparent brain injuries. Our new method, using noninvasive measurements of infant brain electricity, has the potential to provide new ..
  58. Meditation Interventions for Treatment of PTSD in Veterans
    Kelvin O Lim; Fiscal Year: 2013
    ..Exploratory Aims: 1. To evaluate rates of drop-out, compliance, and consumer satisfaction with MBSR. 2. To evaluate acceptability and outcomes of treatment with veterans with mild traumatic brain injuries.
  59. Human Fronto-Parietal Networks for Visual Attention and Memory
    David C Somers; Fiscal Year: 2013
    ..However, diseases, including Alzheimer's and schizophrenia, traumatic brain injuries, stroke, and normal aging all can lead to reductions in the capacity of visual attention and STM and result in ..
  60. A MEMS intracranial pressure device for monitoring brain injuries and disorders
    NIKOLAOS CHRONIS; Fiscal Year: 2010
    ..pressure (ICP) monitoring is an essential diagnostic tool for the efficient treatment of patients with brain injuries (e.g. traumatic brain injuries (TBIs)) and cerebrospinal fluid outflow disorders (e.g. hydrocephalus)...
  61. Traumatic Brain Injury Clinical Trials Network
    Nancy R Temkin; Fiscal Year: 2011
    Traumatic brain injuries represent an important health problem: they occur with high frequency, the population affected contains many previously healthy young people, and they are associated with high mortality and morbidity...
  62. Mechanisms of recovery following severe brain injury
    Nicholas D Schiff; Fiscal Year: 2012
    ..MCS and to develop diagnostic evaluations to identify potential cognitive reserve in patients with severe brain injuries. Preliminary data obtained from multimodal neuroimaging studies of MCS patients supports a working hypothesis ..
  63. Elucidating the Pathology of Impact-Induced Traumatic Brain Injury
    CHAD ALAN TAGGE; Fiscal Year: 2013
    ..Over 1.5 million Americans sustain traumatic brain injuries each year...
  64. MAGNESIUM SULFATE FOR NEUROPROTECTION AFTER BRAIN TRAUMA
    Nancy Temkin; Fiscal Year: 2004
    Traumatic brain injuries represent an important health problem: they occur with high frequency, the population affected contains many previously healthy young people, and they are associated with high mortality and morbidity...
  65. The Effects of Vitamin B3 on Traumatic Brain Injury
    MICHAEL HOANE; Fiscal Year: 2009
    ..It is hoped that the research included in this proposal will help offset this major public health crisis by helping to identify a potential therapy for TBI. ..
  66. A Rodent Model of TBI Suffered During Sustained Combat Operations
    RONALD RIECHERS; Fiscal Year: 2009
    ..This lack of uniformity leads to many challenges in researching the disease process. While the brain injuries suffered by soldiers in the theater of combat operations are variable, several aspects of the environment are ..
  67. Executive Functioning in OEF/OIF Veterans with Traumatic Brain Injury
    Juliana Baldo; Fiscal Year: 2009
    ..Unfortunately, many individuals with mild traumatic brain injuries stemming from exposure to blasts or other accidents do not get properly evaluated and treated, due to the ..
  68. Polymer Constructs for Axon Regeneration in the Central Nervous System
    Rebecca Robinson; Fiscal Year: 2010
    ..Traumatic brain injuries or neurodegenerative diseases cause neuronal cell leads to long-lasting functional impairments...
  69. Pediatric Mild Head Injury: Definition and Consequences
    Ronald Maio; Fiscal Year: 2004
    ..Approximately 90% of pediatric brain injuries are described as mild, yet mild traumatic brain injury(MTBI) research is plagued by problems of classification,..
  70. Zebrafish Models to Study Adult Forebrain Neurogenesis
    Jack Parent; Fiscal Year: 2009
    ..This neurogenic pathway in mammals is stimulated by stroke and other brain injuries. SVZ neuroblasts are diverted from their normal olfactory bulb target to the injured striatum and ..
  71. CHILD AND FAMILY FUNCTIONING AFTER PEDIATRIC HEAD TRAUMA
    JoAnne Youngblut; Fiscal Year: 2001
    ..Even school-age children with mild traumatic brain injuries (TBI) experience deficits in attention and memory that affect every aspect of their lives...
  72. BIOMECHANICS OF BRAIN EDEMA AND INTRACRANIAL PRESSURE
    Anthony Marmarou; Fiscal Year: 2007
    ..Taken in concert, these studies will provide a more indepth understanding of the role of aquaporins in brain injury and introduce novel therapeutic approaches for treating brain edema. ..
  73. How Do Immature Perceptual-Motor Skills Put Child Cyclists at Risk for Injury?
    Jodie M Plumert; Fiscal Year: 2010
    ..Motor vehicles are involved in approximately one-third of all bicycle- related brain injuries and in 90% of all fatalities resulting from bicycle crashes...
  74. Treatment of Motor Function and Balance- A New Tool
    Lars Oddsson; Fiscal Year: 2006
    ..g. those with spinal cord and brain injuries including stroke as well as neurological diseases such as Parkinsonism...