brain edema

Summary

Summary: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)

Top Publications

  1. ncbi Mechanisms of early brain injury after subarachnoid hemorrhage
    Julian Cahill
    Department of Physiology, Loma Linda University Medical School, Loma Linda, California 92354, USA
    J Cereb Blood Flow Metab 26:1341-53. 2006
  2. ncbi Cerebral inflammation contributes to encephalopathy and brain edema in acute liver failure: protective effect of minocycline
    Wenlei Jiang
    Saint Luc Hospital, University of Montreal, Quebec, Canada
    J Neurochem 109:485-93. 2009
  3. ncbi Attenuation of thrombin-induced brain edema by cerebral thrombin preconditioning
    G Xi
    Department of Surgery Neurosurgery, University of Michigan, Ann Arbor, MI, USA
    Stroke 30:1247-55. 1999
  4. pmc Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits
    Zong Zhuang
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu Province, China
    BMC Neurosci 13:47. 2012
  5. pmc Temporary loss of perivascular aquaporin-4 in neocortex after transient middle cerebral artery occlusion in mice
    Didrik S Frydenlund
    Nordic Centre of Excellence for Research in Water Imbalance Related Disorders WIRED, Centre for Molecular Biology and Neuroscience, Department of Anatomy, University of Oslo, P O Box 1105, 0317 Oslo, Norway
    Proc Natl Acad Sci U S A 103:13532-6. 2006
  6. ncbi Occludin expression in microvessels of neoplastic and non-neoplastic human brain
    M C Papadopoulos
    Department of Neurosurgery, Atkinson Morley s Hospital, London SW20 0NE, UK
    Neuropathol Appl Neurobiol 27:384-95. 2001
  7. pmc Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA
    Lancet Neurol 6:258-68. 2007
  8. ncbi Mechanisms of cerebral edema in traumatic brain injury: therapeutic developments
    James J Donkin
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver BC, Canada
    Curr Opin Neurol 23:293-9. 2010
  9. ncbi Effect of early and delayed decompressive craniectomy on secondary brain damage after controlled cortical impact in mice
    Klaus Zweckberger
    Laboratory of Experimental Neurosurgery, Department of Neurosurgery and Institute for Surgical Research, University of Munich Medical Center Grosshadern, Munich, Germany
    J Neurotrauma 23:1083-93. 2006
  10. ncbi Imaging experimental cerebral malaria in vivo: significant role of ischemic brain edema
    Marie France Penet
    Centre de Resonance Magnetique Biologique et Medicale, Unite Mixte de Recherche Centre National de la Recherche Scientifique 6612, 13005 Marseille, France
    J Neurosci 25:7352-8. 2005

Detail Information

Publications320 found, 100 shown here

  1. ncbi Mechanisms of early brain injury after subarachnoid hemorrhage
    Julian Cahill
    Department of Physiology, Loma Linda University Medical School, Loma Linda, California 92354, USA
    J Cereb Blood Flow Metab 26:1341-53. 2006
    ..It is imperative, therefore, to obtain a thorough understanding of the early events that occur after SAH, which will enable future therapies to be developed...
  2. ncbi Cerebral inflammation contributes to encephalopathy and brain edema in acute liver failure: protective effect of minocycline
    Wenlei Jiang
    Saint Luc Hospital, University of Montreal, Quebec, Canada
    J Neurochem 109:485-93. 2009
    Encephalopathy and brain edema are serious complications of acute liver failure (ALF)...
  3. ncbi Attenuation of thrombin-induced brain edema by cerebral thrombin preconditioning
    G Xi
    Department of Surgery Neurosurgery, University of Michigan, Ann Arbor, MI, USA
    Stroke 30:1247-55. 1999
    ..The objective of this study was to investigate whether pretreatment of the brain with low-dose thrombin induces tolerance to a subsequent large dose of thrombin injected into brain parenchyma...
  4. pmc Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits
    Zong Zhuang
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu Province, China
    BMC Neurosci 13:47. 2012
    ..outcomes, and it has been proved that EBI following SAH is closely associated with oxidative stress and brain edema. The present study aimed to examine the effect of hydrogen, a mild and selective cytotoxic oxygen radical ..
  5. pmc Temporary loss of perivascular aquaporin-4 in neocortex after transient middle cerebral artery occlusion in mice
    Didrik S Frydenlund
    Nordic Centre of Excellence for Research in Water Imbalance Related Disorders WIRED, Centre for Molecular Biology and Neuroscience, Department of Anatomy, University of Oslo, P O Box 1105, 0317 Oslo, Norway
    Proc Natl Acad Sci U S A 103:13532-6. 2006
    ..perivascular astrocyte membranes has been shown to be critically involved in the formation and dissolution of brain edema. Cerebral edema is a major cause of morbidity and mortality in stroke...
  6. ncbi Occludin expression in microvessels of neoplastic and non-neoplastic human brain
    M C Papadopoulos
    Department of Neurosurgery, Atkinson Morley s Hospital, London SW20 0NE, UK
    Neuropathol Appl Neurobiol 27:384-95. 2001
    ..Characterizing the molecular pathology of brain endothelial tight junctions may facilitate the design of novel drugs against cerebral oedema...
  7. pmc Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications
    J Marc Simard
    Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA
    Lancet Neurol 6:258-68. 2007
    ....
  8. ncbi Mechanisms of cerebral edema in traumatic brain injury: therapeutic developments
    James J Donkin
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver BC, Canada
    Curr Opin Neurol 23:293-9. 2010
    ..The present review summarizes the most recent advances in the understanding of mechanisms associated with development of posttraumatic cerebral edema, and highlights areas of therapeutic promise...
  9. ncbi Effect of early and delayed decompressive craniectomy on secondary brain damage after controlled cortical impact in mice
    Klaus Zweckberger
    Laboratory of Experimental Neurosurgery, Department of Neurosurgery and Institute for Surgical Research, University of Munich Medical Center Grosshadern, Munich, Germany
    J Neurotrauma 23:1083-93. 2006
    ..current study was therefore to investigate the influence of craniectomy on secondary contusion expansion and brain edema formation and to determine the therapeutic window of craniectomy...
  10. ncbi Imaging experimental cerebral malaria in vivo: significant role of ischemic brain edema
    Marie France Penet
    Centre de Resonance Magnetique Biologique et Medicale, Unite Mixte de Recherche Centre National de la Recherche Scientifique 6612, 13005 Marseille, France
    J Neurosci 25:7352-8. 2005
    ..They improve our understanding of the pathogenesis of cerebral malaria and may provide the necessary noninvasive surrogate markers for quantitative monitoring of treatment...
  11. ncbi Molecular mechanisms of early brain injury after subarachnoid hemorrhage
    Robert P Ostrowski
    Department of Physiology, Loma Linda University, CA 92354, USA
    Neurol Res 28:399-414. 2006
    ..This review presents molecular mechanisms underlying brain injury at its early stages after SAH...
  12. ncbi Brain edema and breakdown of the blood-brain barrier during methamphetamine intoxication: critical role of brain hyperthermia
    Eugene A Kiyatkin
    Behavioural Neuroscience Branch, National Institute on Drug Abuse Intramural Research Program, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Eur J Neurosci 26:1242-53. 2007
    ..control, METH-treated animals had significantly higher brain levels of water, Na(+), K(+) and Cl(-), suggesting brain edema, and intense immunostaining for albumin, indicating breakdown of the BBB...
  13. ncbi Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products
    Feng ping Huang
    Department of Neurosurgery, University of Michigan, Ann Arbor 48109 0532, USA
    J Neurosurg 96:287-93. 2002
    The mechanisms involved in brain edema formation following intracerebral hemorrhage (ICH) have not been fully elucidated. The authors have found that red blood cell lysis plays an important role in edema development after ICH...
  14. pmc TIMP-1/MMP-9 imbalance in brain edema in rats with fulminant hepatic failure
    Satoshi Yamamoto
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    J Surg Res 134:307-14. 2006
    Fulminant hepatic failure (FHF) is a devastating disease. When coma sets in, brain edema develops, changing FHF into a lethal condition. Liver transplantation is the definitive treatment...
  15. ncbi Simvastatin reduces secondary brain injury caused by cortical contusion in rats: possible involvement of TLR4/NF-kappaB pathway
    Gang Chen
    Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China
    Exp Neurol 216:398-406. 2009
    ..of simvastatin following TBI significantly ameliorated the secondary brain damage, such as cortical apoptosis, brain edema, blood-brain barrier (BBB) impairment, and motor deficits...
  16. ncbi Increased blood-brain barrier permeability and brain edema after focal cerebral ischemia induced by hyperlipidemia: role of lipid peroxidation and calpain-1/2, matrix metalloproteinase-2/9, and RhoA overactivation
    Ayman ElAli
    Department of Neurology, University Hospital Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Stroke 42:3238-44. 2011
    ..Hyperlipidemia is a highly prevalent risk factor for ischemic stroke. Its impact on brain injury and blood-brain barrier permeability, so far, has not been assessed in animal models of ischemic stroke...
  17. ncbi Up-regulation of endothelial endothelin-1 expression prior to vasogenic edema formation in the rat piriform cortex following status epilepticus
    Seung Mook Jo
    Department of Emergency Medical Services, Eulji University, Seongnam, Gyeonggi do 461 713, South Korea
    Neurosci Lett 501:25-30. 2011
    ..Taken together, our findings suggest that endothelial ET-1 expression may contribute to SE-induced vasogenic edema formation via brain-blood barrier disruption at AQP4/MCP-1 independent manners...
  18. pmc Cerebral ischemia-reperfusion injury in rats--a 3 T MRI study on biphasic blood-brain barrier opening and the dynamics of edema formation
    Deepu R Pillai
    Department of Neurology, Regensburg University Medical Center, Regensburg, Germany
    J Cereb Blood Flow Metab 29:1846-55. 2009
    ..Stroke therapy aimed at vasogenic edema and drug delivery for neuroprotection may also be guided according to the functional status of the BBB, and these findings have to be confirmed in human stroke...
  19. ncbi Continuous measurements of cerebral tissue oxygen pressure during hyperbaric oxygenation--HBO effects on brain edema and necrosis after severe brain trauma in rabbits
    A Niklas
    Department of Neurology, University of Leipzig, Liebigstr 22a, Leipzig, 04103 Germany
    J Neurol Sci 219:77-82. 2004
    ..Severe brain injury is one of the most frequent causes of severe disability in the young. In acute management of brain trauma, new approaches based on experimental animal investigations should be sought...
  20. ncbi Effect of melatonin on intracranial pressure and brain edema following traumatic brain injury: role of oxidative stresses
    Fatemeh Dehghan
    Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
    Arch Med Res 44:251-8. 2013
    Traumatic brain injury (TBI) is one of the main causes of brain edema and increased intracranial pressure (ICP). In the clinic it is essential to limit the development of ICP after TBI...
  21. ncbi Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure
    Cristina R Bosoi
    Neuroscience Research Unit, Hôpital Saint Luc CRCHUM, Universite de Montreal, Montreal, QC H2X 1P1, Canada
    Free Radic Biol Med 52:1228-35. 2012
    ..This study aimed to determine the relationship between chronic hyperammonemia, oxidative stress, and brain edema (BE) in two rat models of HE: portacaval anastomosis (PCA) and bile-duct ligation (BDL)...
  22. ncbi Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: role of glutamine redefined
    Paul Desjardins
    Neuroscience Research Unit, Saint Luc Hospital, CHUM, University of Montreal, Montreal, Quebec, Canada
    Neurochem Int 60:690-6. 2012
    Acute liver failure (ALF) is characterized neuropathologically by cytotoxic brain edema and biochemically by increased brain ammonia and its detoxification product, glutamine...
  23. ncbi Luteolin downregulates TLR4, TLR5, NF-κB and p-p38MAPK expression, upregulates the p-ERK expression, and protects rat brains against focal ischemia
    Huimin Qiao
    Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, PR China
    Brain Res 1448:71-81. 2012
    ..Whether this protective effect applies to ischemic injury in brain is still unknown, we therefore investigate the potential neuroprotective role of luteolin in ischemic stroke and the underlying mechanisms...
  24. ncbi Time course of aquaporin expression after transient focal cerebral ischemia in mice
    Marlise de Castro Ribeiro
    Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Neurosci Res 83:1231-40. 2006
    ..The expression of AQP1 remained unchanged. These results suggest that AQP4, but not AQP1 or AQP9, may play an important role in water movement associated with the pathophysiology of edema after transient cerebral ischemia in the mouse...
  25. ncbi The development of an improved preclinical mouse model of intracerebral hemorrhage using double infusion of autologous whole blood
    Jian Wang
    Department of Anesthesiology Critical Care Medicine, School of Medicine, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Brain Res 1222:214-21. 2008
    ..We investigated the effect of intrastriatal infusion of blood on hematoma volume, neurologic function, brain edema and swelling, and markers of neuroinflammation and oxidative DNA damage...
  26. pmc Wogonin improves histological and functional outcomes, and reduces activation of TLR4/NF-κB signaling after experimental traumatic brain injury
    Chien Cheng Chen
    Department of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, Taipei, Taiwan, Republic of China
    PLoS ONE 7:e30294. 2012
    ..of wogonin, a flavonoid with potent anti-inflammatory properties, on functional and histological outcomes, brain edema, and toll-like receptor 4 (TLR4)- and nuclear factor kappa B (NF-κB)-related signaling pathways in mice ..
  27. ncbi Pinocembrin attenuates blood-brain barrier injury induced by global cerebral ischemia-reperfusion in rats
    Fanrui Meng
    National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P R China
    Brain Res 1391:93-101. 2011
    ..Neurological scores and brain edema were evaluated...
  28. ncbi Targeted suppression of claudin-5 decreases cerebral oedema and improves cognitive outcome following traumatic brain injury
    Matthew Campbell
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland
    Nat Commun 3:849. 2012
    ....
  29. ncbi The role of endogenous versus exogenous tPA on edema formation in murine ICH
    Ruth Thiex
    Department of Neurosurgery, Aachen University, Aachen, Germany
    Exp Neurol 189:25-32. 2004
    ..In conclusion, the role of the endogenous tPA appears to be limited to the early phase of edema formation, whereas exogenous rtPA is edema-promoting between days 3 and 7 after ICH...
  30. ncbi Inhibition of myosin light chain kinase reduces brain edema formation after traumatic brain injury
    Clara Luh
    Department of Anesthesiology, Medical Center of the Johannes Gutenberg University, Mainz, Germany
    J Neurochem 112:1015-25. 2010
    The role of the endothelial contractile apparatus in the process of brain edema formation after brain trauma is not characterized...
  31. ncbi Demonstration of interstitial cerebral edema with diffusion tensor MR imaging in type C hepatic encephalopathy
    Ravindra A Kale
    Department of Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
    Hepatology 43:698-706. 2006
    ..In conclusion, the increase in MD with no concomitant changes in FA in cirrhosis with minimal or early HE indicates the presence of reversible interstitial brain edema.
  32. ncbi The blood-brain barrier is continuously open for several weeks following transient focal cerebral ischemia
    D Strbian
    Department of Neurology, Helsinki University Central Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland
    Neuroscience 153:175-81. 2008
    ..This is the first systematic and extensive study fully demonstrating BBB leakage dynamics following transient brain ischemia and the findings are of major clinical and experimental interest...
  33. ncbi Factors affecting the outcome of decompressive craniectomy for large hemispheric infarctions: a prospective cohort study
    C Kilincer
    Department of Neurosurgery, Trakya University Medical Faculty, Edirne, Turkey
    Acta Neurochir (Wien) 147:587-94; discussion 594. 2005
    ..The aims of this study were to identify specific factors that can be used to predict functional outcome, thus establish predictive criteria to reduce poor surgical results...
  34. ncbi Inhibition of bradykinin B2 receptors before, not after onset of experimental subarachnoid hemorrhage prevents brain edema formation and improves functional outcome
    Serge C Thal
    Institute for Surgical Research, University of Munich Medical Center Grosshadern, Munich, Germany
    Crit Care Med 37:2228-34. 2009
    b>Brain edema following subarachnoid hemorrhage (SAH) is a result of impairment of cerebral autoregulation and breakdown of the blood-brain barrier...
  35. ncbi Edema and brain trauma
    A W Unterberg
    Department of Neurosurgery, Ruprecht Karls University of Heidelberg, Im Neuenheimer Feld 400, D 69120 Heidelberg, Germany
    Neuroscience 129:1021-9. 2004
    b>Brain edema leading to an expansion of brain volume has a crucial impact on morbidity and mortality following traumatic brain injury (TBI) as it increases intracranial pressure, impairs cerebral perfusion and oxygenation, and contributes ..
  36. ncbi Ischemic brain edema
    G A Rosenberg
    Department of Neurology, University of New Mexico, Albuquerque 87131, USA
    Prog Cardiovasc Dis 42:209-16. 1999
    b>Brain edema is a life-threatening complication of cerebral infarction. The molecular cascade initiated by cerebral ischemia includes the loss of membrane ionic pumps and cell swelling...
  37. ncbi Acute administration of 3,4-methylenedioxymethamphetamine induces profound hyperthermia, blood-brain barrier disruption, brain edema formation, and cell injury
    Hari Shanker Sharma
    Laboratory of Neurochemistry, Division of Neurotoxicology, National Center of Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA
    Ann N Y Acad Sci 1139:242-58. 2008
    ..of the blood-brain barrier (BBB), this investigation examined the effects of acute MDMA on BBB dysfunction, brain edema, and cell injury in rats and mice. When MDMA (40 mg/kg, i.p...
  38. ncbi The cerebral effects of ascent to high altitudes
    Mark H Wilson
    Centre for Altitude, Space and Extreme Environment Medicine, University College London, London, UK
    Lancet Neurol 8:175-91. 2009
    ..The effects of hypobaric hypoxia might also provide new insights into the understanding of hypoxia in the clinical setting...
  39. ncbi Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema
    Nicolai E Savaskan
    Brain Research Institute, Swiss Federal Institute of Technology and University Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nat Med 14:629-32. 2008
    Neurodegeneration and brain edema are hallmarks of human malignant brain tumors...
  40. ncbi Potential contribution of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 to blood-brain barrier disruption and brain edema after experimental subarachnoid hemorrhage
    Zhong Wang
    Department of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu Province, People s Republic of China
    J Mol Neurosci 48:273-80. 2012
    ..Brain samples were extracted at 48 h after SAH and examined for protein expressions, BBB impairment, and brain edema. Following SAH, remarkable edema and BBB extravasations were observed...
  41. ncbi High-altitude illness
    Buddha Basnyat
    Nepal International Clinic, Kathmandu, Nepal Himalayan Rescue Association, Kathmandu, Nepal
    Lancet 361:1967-74. 2003
    ..Despite investigation of other agents, acetazolamide remains the preferred drug for preventing AMS. The next few years are likely to see many advances in the understanding of the causes and management of high-altitude illness...
  42. ncbi Astrocytic induction of matrix metalloproteinase-9 and edema in brain hemorrhage
    Emiri Tejima
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA, USA
    J Cereb Blood Flow Metab 27:460-8. 2007
    We tested the hypothesis that astrocytic matrix metalloproteinase-9 (MMP-9) mediates hemorrhagic brain edema. In a clinical case of hemorrhagic stroke, MMP-9 co-localized with astrocytes and neurons in peri-hematoma areas...
  43. ncbi Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels
    Devin K Binder
    Department of Neurological Surgery, University of California, San Francisco, 94110, USA
    Glia 53:631-6. 2006
    ..5 +/- 0.1 and 6.6 +/- 0.7 s, respectively). These results implicate AQP4 in the expression and termination of seizure activity and support the hypothesis that AQP4 is coupled to potassium homeostasis in vivo...
  44. pmc Minocycline reduces intracerebral hemorrhage-induced brain injury
    Jimin Wu
    Medical School, Zhejiang University, Hangzhou, China Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA
    Neurol Res 31:183-8. 2009
    ..The present study investigated if thrombin stimulates tumor necrosis factor-alpha and interleukin-1beta secretion in vitro and if microglial inhibition reduces intracerebral hemorrhage-induced brain injury in vivo...
  45. ncbi A brain tumor segmentation framework based on outlier detection
    Marcel Prastawa
    Department of Computer Science, University of North Carolina, CB 3175, Sitterson Hall, Chapel Hill, NC 27599, USA
    Med Image Anal 8:275-83. 2004
    ..The segmentation procedure has been applied to three real datasets, representing different tumor shapes, locations, sizes, image intensities, and enhancement...
  46. ncbi Experimental acute pancreatitis results in increased blood-brain barrier permeability in the rat: a potential role for tumor necrosis factor and interleukin 6
    G Farkas
    Department of Surgery, Albert Szent Gyorgyi University Medical School, Szeged, Hungary
    Neurosci Lett 242:147-50. 1998
    ..We conclude that cytokines, such as TNF and IL-6, may contribute to the vasogenic brain edema formation during acute pancreatitis.
  47. ncbi Early hemicraniectomy in patients with complete middle cerebral artery infarction
    S Schwab
    Department of Neurology, University of Heidelberg, Germany
    Stroke 29:1888-93. 1998
    ..Several reports indicate a beneficial effect of hemicraniectomy in this situation. However, whether and when decompressive surgery is indicated in these patients is still a matter of debate...
  48. ncbi Free radicals as triggers of brain edema formation after stroke
    Ji Hoe Heo
    Department of Neurology, National Core Research Center for Nanomedical Technology, Brain Korea 21 Project for Medical Sciences, Seoul
    Free Radic Biol Med 39:51-70. 2005
    b>Brain edema is a leading cause of death after stroke. Cytotoxic edema, which is most severe in astrocytes, begins within a few minutes of adenosine triphosphate depletion and reflects the ultimate infarct size...
  49. ncbi Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus
    Ji Eun Kim
    Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chunchon, Kangwon Do 200 702, South Korea
    J Comp Neurol 518:4612-28. 2010
    ..cortex (PC) and the hippocampus of pilocarpine-induced rat epilepsy model to elucidate the roles of AQP4 in brain edema following status epilepticus (SE)...
  50. ncbi Alpha-syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia
    Mahmood Amiry-Moghaddam
    Centre for Molecular Biology and Neuroscience, and Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    FASEB J 18:542-4. 2004
    The formation of brain edema, commonly occurring as a potentially lethal complication of acute hyponatremia, is delayed following knockout of the water channel aquaporin-4 (AQP4)...
  51. ncbi Aquaporin-4 and brain edema
    Marios C Papadopoulos
    Department of Medicine, University of California, San Francisco, CA 94143 0521, USA
    Pediatr Nephrol 22:778-84. 2007
    ..AQP4-null mice are protected from cellular (cytotoxic) brain edema produced by water intoxication, brain ischemia, or meningitis...
  52. pmc Brain swelling and mannitol therapy in adult cerebral malaria: a randomized trial
    Sanjib Mohanty
    Depatment of Medicine and Radiology, Ispat General Hospital, Rourkela, Orissa, India
    Clin Infect Dis 53:349-55. 2011
    ..Coma is a frequent presentation of severe malaria in adults and an important cause of death. The role of cerebral swelling in its pathogenesis, and the possible benefit of intravenous mannitol therapy to treat this, is uncertain...
  53. ncbi Minimally invasive procedures for evacuation of intracerebral hemorrhage reduces perihematomal glutamate content, blood-brain barrier permeability and brain edema in rabbits
    Guofeng Wu
    Department of Emergency, Affiliated Hospital, Guiyang Medical College, Guiyang City, Guizhou Province, China
    Neurocrit Care 14:118-26. 2011
    ....
  54. ncbi Spontaneous intracerebral hemorrhage in humans: hematoma enlargement, clot lysis, and brain edema
    G Wu
    Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China
    Acta Neurochir Suppl 96:78-80. 2006
    ..We investigated hematoma growth, clot lysis, and brain edema formation in patients with spontaneous ICH...
  55. ncbi Decrease in dystrophin expression prior to disruption of brain-blood barrier within the rat piriform cortex following status epilepticus
    Seung Hun Sheen
    Department of Neurosurgery, College of Medicine, Hallym University, Chunchon 200 702, Republic of Korea
    Brain Res 1369:173-83. 2011
    ....
  56. ncbi Neuroprotective effects of citicoline on brain edema and blood-brain barrier breakdown after traumatic brain injury
    M K Baskaya
    Department of Neurosurgery, Louisiana State University Medical Center, Shreveport 71130 3932, USA
    J Neurosurg 92:448-52. 2000
    ..However, in no study has such protection been shown after traumatic brain injury (TBI). In this study the authors examined the effect of CDPC on secondary injury factors, brain edema and blood-brain barrier (BBB) breakdown, after TBI.
  57. pmc Isoflurane posttreatment reduces brain injury after an intracerebral hemorrhagic stroke in mice
    Nikan H Khatibi
    Department of Anesthesiology, Loma Linda University Medical Center, 11234 Anderson St, Loma Linda, CA 92354, USA
    Anesth Analg 113:343-8. 2011
    ..we investigated whether isoflurane posttreatment can preserve the structural integrity of the brain by reducing apoptotic damage and, in turn, improve functional outcome by amelioration of brain edema and neurobehavioral deficits.
  58. ncbi Distinct imaging patterns and lesion distribution in posterior reversible encephalopathy syndrome
    W S Bartynski
    Department of Radiology, Division of Neuroradiology, Presbyterian University Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    AJNR Am J Neuroradiol 28:1320-7. 2007
    ..We evaluated lesion distribution with CT and MR in a large cohort of patients who experienced PRES to comprehensively assess the imaging patterns identified...
  59. pmc Role of the p38 mitogen-activated protein kinase/cytosolic phospholipase A2 signaling pathway in blood-brain barrier disruption after focal cerebral ischemia and reperfusion
    Chikako Nito
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305 5487, USA
    J Cereb Blood Flow Metab 28:1686-96. 2008
    ..These findings suggest that the p38 MAPK/cPLA(2) pathway may promote BBB disruption with secondary vasogenic edema and that superoxide anions can stimulate this pathway after ischemia-reperfusion injury...
  60. pmc Delayed increase of astrocytic aquaporin 4 after juvenile traumatic brain injury: possible role in edema resolution?
    A M Fukuda
    Department of Physiology, Loma Linda University, Loma Linda, CA 92354, USA
    Neuroscience 222:366-78. 2012
    ..Group differences were not observed for AQP9. Overall, our observations confirm that astrocyticAQP4 plays a more central role than AQP1 or AQP9 during the edema process in the young brain...
  61. ncbi Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress
    Xituan Ji
    Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xiing Hospital, Fourth Military Medical University, Xi an 710032, Shaanxi Province, PR China
    Brain Res 1354:196-205. 2010
    ..In the present study, we investigated the effectiveness of H(2) therapy on brain edema, blood-brain barrier (BBB) breakdown, neurological dysfunction and injury volume in TBI-challenged rats...
  62. pmc Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice
    Justin H Nguyen
    Department of Transplantation, Division of Transplant Surgery, Mayo Clinic College of Medicine, 4205 Belfort Road, Suite 1100, Jacksonville, FL 32216, USA
    J Hepatol 44:1105-14. 2006
    Fulminant hepatic failure (FHF) can be dreadful. When coma sets in, brain edema develops taking FHF into a lethal course. Mechanisms of brain extravasation leading to brain edema remain incompletely understood...
  63. ncbi The Na-K-Cl cotransporter in the brain edema of acute liver failure
    Arumugam R Jayakumar
    Department of Pathology, University of Miami, School of Medicine, Miami, FL 33101, USA
    J Hepatol 54:272-8. 2011
    Astrocyte swelling and brain edema associated with increased intracranial pressure are major complications of acute liver failure (ALF). The mechanism for such astrocyte swelling/brain edema, however, is not well understood...
  64. ncbi Aquaporin-4 and traumatic brain edema
    Miao Xu
    Department of Critical Care Medicine, Sir Run Run Shaw Hospital, Medical College of Zhejiang University and Sir Run Run Shaw Institute of Clinical Medicine, Hangzhou, China
    Chin J Traumatol 13:103-10. 2010
    b>Brain edema leading to an expansion of brain volume has a crucial impact on morbidity and mortality following traumatic brain injury as it increases intracranial pressure, impairs cerebral perfusion and oxygenation, and contributes to ..
  65. ncbi Extent of peritumoral brain edema correlates with prognosis, tumoral growth pattern, HIF1a expression and angiogenic activity in patients with single brain metastases
    Thomas Spanberger
    Division of Neuroradiology, Department of Radiology, Medical University of Vienna, Vienna, Austria
    Clin Exp Metastasis 30:357-68. 2013
    To analyze the prognostic value of the extent of peritumoral brain edema in patients operated for single brain metastases (BM), we retrospectively evaluated pre-operative magnetic resonance images in a discovery cohort of 129 patients ..
  66. pmc Tumor necrosis factor-α-mediated threonine 435 phosphorylation of p65 nuclear factor-κB subunit in endothelial cells induces vasogenic edema and neutrophil infiltration in the rat piriform cortex following status epilepticus
    Ji Eun Kim
    Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chunchon, Kangwon Do, South Korea
    J Neuroinflammation 9:6. 2012
    ....
  67. ncbi Bench to bedside: brain edema and cerebral resuscitation: the present and future
    Feng Xiao
    Department of Emergency Medicine, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Acad Emerg Med 9:933-46. 2002
    ..b>Brain edema has been recently documented in experimental CA followed by one hour of ROSC...
  68. ncbi Peritumoral edema after stereotactic radiosurgery for intracranial meningiomas and molecular factors that predict its development
    Peter Kan
    Department of Neurosurgery, University of Utah Health Sciences Center, 175 N Medical Drive East, Salt Lake City, UT 84132, USA
    J Neurooncol 83:33-8. 2007
    ..Although uncommon, peritumoral edema can develop as a delayed complication after SRS. The purpose of the study was to evaluate the clinical and molecular risk factors for peritumoral edema after SRS for intracranial meningiomas...
  69. ncbi Neurological complications of acute ischaemic stroke
    Joyce S Balami
    Acute Stroke Programme, Department of Medicine and Clinical Geratology, Oxford Radcliffe NHS Trust, Oxford, UK
    Lancet Neurol 10:357-71. 2011
    ....
  70. ncbi Dietary virgin olive oil reduces blood brain barrier permeability, brain edema, and brain injury in rats subjected to ischemia-reperfusion
    Fatemeh Mohagheghi
    Faculty of Biological Sciences, Shahid Beheshti University, G C Tehran, Iran
    ScientificWorldJournal 10:1180-91. 2010
    ..After 24-h reperfusion, neurological deficit scores, infarct volume, brain edema, and blood brain barrier permeability were each assessed in subgroups of six animals drawn from each main group...
  71. ncbi Bilateral decompressive craniectomy for patients with malignant diffuse brain swelling after severe traumatic brain injury: a 37-case study
    Ying hui Bao
    Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, People s Republic of China
    J Neurotrauma 27:341-7. 2010
    ..9%). Our data show that BDC offers immediate reductions in intracranial hypertension, and perhaps contributes to satisfactory outcomes in patients with bilateral diffuse brain swelling following severe TBI...
  72. ncbi Substance P is associated with the development of brain edema and functional deficits after traumatic brain injury
    James J Donkin
    Discipline of Pathology, University of Adelaide, Adelaide, South Australia, Australia
    J Cereb Blood Flow Metab 29:1388-98. 2009
    b>Brain edema and swelling is a critical factor in the high mortality and morbidity associated with traumatic brain injury (TBI)...
  73. ncbi The role of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 in blood-brain barrier disruption and brain edema after traumatic brain injury
    Tetsuhiro Higashida
    Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosurg 114:92-101. 2011
    ..role of hypoxia-inducible factor-1α (HIF-1α), aquaporin-4 (AQP-4), and matrix metalloproteinase-9 (MMP-9) in blood-brain barrier (BBB) permeability alterations and brain edema formation in a rodent traumatic brain injury (TBI) model.
  74. ncbi Peritumoral edema on MRI at initial diagnosis: an independent prognostic factor for glioblastoma?
    K Schoenegger
    Clinical Division of Oncology, Department of Medicine I, General Hospital, All Medical University of Vienna, Wahringer Gurtel, Austria
    Eur J Neurol 16:874-8. 2009
    Peritumoral brain edema in glioblastoma patients is a frequently encountered phenomenon that strongly contributes to neurological signs and symptoms. The role of peritumoral edema as a prognostic factor is controversial.
  75. pmc Perilesional brain oedema and seizure activity in patients with calcified neurocysticercosis: a prospective cohort and nested case-control study
    Theodore E Nash
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Lancet Neurol 7:1099-105. 2008
    ..Transient perilesional brain oedema is seen around the calcified foci but its importance, association with seizures, incidence, and pathophysiology are unknown...
  76. ncbi Continuous ventricular cerebrospinal fluid drainage with intracranial pressure monitoring for management of posttraumatic diffuse brain swelling
    Almir Ferreira de Andrade
    Department of Neurology and Neurosurgery, Clinical s Hospital, University of Sao Paulo Medical School, SP, Brazil
    Arq Neuropsiquiatr 69:79-84. 2011
    ..The aim of the present study was describe outcomes in a series of 57 patients with diffuse brain swelling underwent to intracranial pressure (ICP) monitoring...
  77. ncbi Systemic complement depletion diminishes perihematomal brain edema in rats
    G Xi
    Department of Surgery Neurosurgery, University of Michigan, Ann Arbor 48109 0532, USA
    Stroke 32:162-7. 2001
    ..It remains unclear, however, whether depleting the complement system will improve injury resulting from ICH. This study investigated the effects of systemic complement depletion on brain edema formation after ICH.
  78. pmc Normobaric hyperoxia inhibits NADPH oxidase-mediated matrix metalloproteinase-9 induction in cerebral microvessels in experimental stroke
    Wenlan Liu
    College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
    J Neurochem 107:1196-205. 2008
    ..expression, NADPH oxidase activity, and MMP-9 induction, which led to significantly less BBB damage and brain edema in the ischemic brain...
  79. ncbi Severity profile of penetrating ballistic-like brain injury on neurofunctional outcome, blood-brain barrier permeability, and brain edema formation
    Deborah A Shear
    Brain Trauma Neuroprotection and Neurorestoration, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    J Neurotrauma 28:2185-95. 2011
    ..ballistic-like brain injury (PBBI) on neurofunctional outcome, blood-brain barrier (BBB) permeability, and brain edema formation...
  80. pmc Differential aquaporin 4 expression during edema build-up and resolution phases of brain inflammation
    Thomas Tourdias
    INSERM U, 1049 Neuroinflammation, imagerie et thérapie de la sclérose en plaques, F 33076 Bordeaux, France
    J Neuroinflammation 8:143. 2011
    ....
  81. pmc Curcumin attenuates cerebral edema following traumatic brain injury in mice: a possible role for aquaporin-4?
    Melissa D Laird
    Department of Neurosurgery, Medical College of Georgia, Augusta, Georgia, USA
    J Neurochem 113:637-48. 2010
    ..As a whole, these data suggest clinically achievable concentrations of curcumin reduce glial activation and cerebral edema following neurotrauma, a finding which warrants further investigation...
  82. ncbi The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema
    Peter Nissen Bjerring
    Dept Hepatology, section A 2121, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Metab Brain Dis 24:5-14. 2009
    ..Finally, potential therapeutic targets and future perspectives are briefly discussed...
  83. pmc Blood-brain barrier breakdown in septic encephalopathy and brain tumours
    D C Davies
    Department of Anatomy and Developmental Biology, St George s Hospital Medical School, Tooting, London, UK
    J Anat 200:639-46. 2002
    ..These results suggest that the pathophysiology of brain oedema is multifactorial, but that there may be common processes operating regardless of the aetiology...
  84. ncbi Intracerebral administration of interleukin-1beta and induction of inflammation, apoptosis, and vasogenic edema
    S Holmin
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    J Neurosurg 92:108-20. 2000
    ..This investigation was undertaken to analyze the effect of intracerebral administration of IL-1beta and TNFalpha on inflammatory response, cell death, and edema development...
  85. ncbi The long-term effect of recombinant tissue-plasminogen-activator (rt-PA) on edema formation in a large-animal model of intracerebral hemorrhage
    Ruth Thiex
    Department of Neurosurgery, Aachen University, Pauwelsstr 30, 52057 Aachen, Germany
    Neurol Res 25:254-62. 2003
    ....
  86. ncbi Hypoxia-induced astrocytic reaction and increased vascular permeability in the rat cerebellum
    C Kaur
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Glia 54:826-39. 2006
    Hypoxia is an important factor linked to induction of vascular leakage and formation of brain edema. In this connection, astrocytes associated closely with the blood vessels are deemed to be involved...
  87. ncbi Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices
    Roland Reinehr
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Glia 55:758-71. 2007
    ..The findings further support a close interrelation between osmotic and oxidative stress in astrocytes, which may be relevant to different brain pathologies including hepatic encephalopathy...
  88. ncbi Blood-brain barrier disruption following subarchnoid hemorrhage may be faciliated through PUMA induction of endothelial cell apoptosis from the endoplasmic reticulum
    Junhao Yan
    Department of Anatomy and Histology, Peking University Health Science Center, Beijing 100191, China
    Exp Neurol 230:240-7. 2011
    ..Outcomes measured include mortality rate, brain edema, BBB disruption, and neurobehavioral testing...
  89. ncbi Tumor necrosis factor-α affects blood-brain barrier permeability in acetaminophen-induced acute liver failure
    Wen Wang
    Department of Infectious Diseases, The First Affiliated Hospital, China Medical University, No 55 Nanjing Street, Shenyang, Liaoning Province, China
    Eur J Gastroenterol Hepatol 23:552-8. 2011
    ..The aim of this study was to investigate the role of tumor necrosis factor α (TNFα) in changing the permeability of the blood-brain barrier (BBB) during acetaminophen (APAP)-induced ALF...
  90. ncbi Water, water, everywhere: sodium and water balance and the injured brain
    Anne Claire Lukaszewicz
    Department of Anesthesiology and Critical Care, Hopital Lariboisiere, Assistance Publique Hopitaux de Paris, Universite Paris 7 Denis Diderot, France
    Curr Opin Anaesthesiol 24:138-43. 2011
    ..This review reports on update of both significant experimental and clinical findings on factors implicated in oedema formation...
  91. ncbi Metabolic findings on 3T 1H-MR spectroscopy in peritumoral brain edema
    R Ricci
    Department of Neuroradiology, Bellaria Hospital, and the Department of Biochemistry G Moruzzi, University of Bologna, Italy
    AJNR Am J Neuroradiol 28:1287-91. 2007
    Little is known about the metabolic properties of brain edema associated with tumors...
  92. ncbi Inflammation and brain edema: new insights into the role of chemokines and their receptors
    S M Stamatovic
    Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan 48109 0532, USA
    Acta Neurochir Suppl 96:444-50. 2006
    b>Brain edema is associated with a variety of neuropathological conditions such as brain trauma, ischemic and hypoxic brain injury, central nervous system infection, acute attacks of multiple sclerosis, and brain tumors...
  93. pmc Emerging concepts in acute mountain sickness and high-altitude cerebral edema: from the molecular to the morphological
    Damian Miles Bailey
    Neurovascular Research Laboratory, Faculty of Health, Science and Sport, University of Glamorgan, Pontypridd, CF37 1DL, South Wales, UK
    Cell Mol Life Sci 66:3583-94. 2009
    ..space to the intracellular space without any evidence for further barrier disruption or additional increment in brain edema, swelling or pressure...
  94. ncbi Hemicraniectomy for massive middle cerebral artery territory infarction: a systematic review
    Rishi Gupta
    Department of Neurology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Stroke 35:539-43. 2004
    ..Our objective was to review the literature to identify patients most likely to benefit from hemicraniectomy...
  95. ncbi Aggressive decompressive surgery in patients with massive hemispheric embolic cerebral infarction associated with severe brain swelling
    K Mori
    Department of Neurosurgery, Juntendo University, Izunagaoka Hospital, Tagata-gun, Shizuoka, Japan
    Acta Neurochir (Wien) 143:483-91; discussion 491-2. 2001
    ..Decompressive surgical treatment dramatically improves the mortality of massive hemispheric infarction...
  96. ncbi The protective effect of alpha lipoic acid against traumatic brain injury in rats
    Hale Z Toklu
    Marmara University, School of Pharmacy, Department of Pharmacology, Istanbul, Turkey
    Free Radic Res 43:658-67. 2009
    ..These findings suggest that LA exerts neuroprotection by preserving BBB permeability and by reducing brain oedema probably by its anti-inflammatory and antioxidant properties in the TBI model...
  97. ncbi Water entry into astrocytes during brain edema formation
    Gabriele Nase
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo and CMBN, Blindern, NO 0317 Oslo, Norway
    Glia 56:895-902. 2008
    The process of brain edema formation has been studied extensively at the macroscopic level. In contrast, little is known about water fluxes and volume changes at the cellular level in the initial phase of brain edema...
  98. ncbi Astrocytic tissue remodeling by the meningitis neurotoxin pneumolysin facilitates pathogen tissue penetration and produces interstitial brain edema
    Sabrina Hupp
    DFG Membrane Cytoskeleton Interaction Group, Institute of Pharmacology and Toxicology and Rudolf Virchow Center for Experimental Medicine, University of Wurzburg, Versbacherstr 9, 97078 Wurzburg, Germany
    Glia 60:137-46. 2012
    ..We suggest that PLY can increase the permeability of brain tissue toward pathogenic factors and bacteria in the course of meningitis, thus contributing to the deterioration caused by the disease...
  99. ncbi Neuroprotective effect of delayed moderate hypothermia after focal cerebral ischemia: an MRI study
    R Kollmar
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 33:1899-904. 2002
    ..We examined the influence of delayed hypothermia on secondary ischemic injury, MRI lesion size, and neurological outcome after transient focal cerebral ischemia in a rat model...
  100. ncbi Temporal profile of cerebrospinal fluid glutamate, interleukin-6, and tumor necrosis factor-alpha in relation to brain edema and contusion following controlled cortical impact injury in rats
    J F Stover
    Department of Neurosurgery, Charite Virchow Medical Center, Berlin, Germany
    Neurosci Lett 288:25-8. 2000
    ..7+/-1 pg/ml) (P<0.005). The observed different temporal profile of CSF glutamate, IL-6, and TNF-alpha following focal traumatic brain injury could be of therapeutic importance...
  101. ncbi Brain hypoxanthine concentration correlates to lactate/pyruvate ratio but not intracranial pressure in patients with acute liver failure
    Peter Nissen Bjerring
    Department of Hepatology, Rigshospitalet, University Hospital of Copenhagen, Denmark
    J Hepatol 53:1054-8. 2010
    ..Furthermore, we expect the purines and L/P ratio to correlate with intracranial pressure (ICP) (positively), and cerebral perfusion pressure (CPP) (negatively)...

Research Grants63

  1. NFkB in the Astrocyte Swelling/Brain Edema with Acute Liver Failure
    MICHAEL DAVID NORENBERG; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Brain edema and associated intracranial hypertension are major complications of acute liver failure (ALF), which has a high mortality and for which therapeutic options are largely limited to an ..
  2. Brain Vascular Studies in Cardiac and Orthopedic Surgery
    William Brown; Fiscal Year: 2009
    ..The outcomes will include: brain edema; intravital visualization and recording of intravascular emboli;BBB leakage into the cerebrospinal fluid; ..
  3. Brain Vascular Studies in Cardiac and Orthopedic Surgery
    David Stump; Fiscal Year: 2013
    ..The outcomes will include: brain edema;intravital visualization and recording of intravascular emboli;BBB leakage into the cerebrospinal fluid;emboli ..
  4. Heat shock proteins in brain ischemia and stroke
    Midori A Yenari; Fiscal Year: 2013
    ..Brain ischemia frequently causes disruption of the blood brain barrier (BBB) leading to brain edema and hemorrhage which can complicate an already catastrophic illness...
  5. Neurovascular Protection for Early Brain Injury after SAH
    John H Zhang; Fiscal Year: 2013
    ..NIH/NS053407 2007- 2011) we have studied endothelial protective mechanisms against cerebral vasospasm and brain edema. Our studies were the pioneering observations that early brain injury which is featured by an elevated ..
  6. Astrocyte swelling/Brain Edema in Acute Liver Failure: Role of Endothelial Cells
    MICHAEL DAVID NORENBERG; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Project Summary/Abstract Brain edema and associated intracranial hypertension are major and potentially lethal complications of acute liver failure (ALF) that have limited therapeutic options It is ..
  7. BIOMECHANICS OF BRAIN EDEMA AND INTRACRANIAL PRESSURE
    CHRISTINA ROSE MARMAROU; Fiscal Year: 2012
    ..At the conclusion of the experiments, brain edema and total tissue sodium and potassium will be measured to gauge the effect of the pharmacologic suppression of ..
  8. Molecular Mechanisms of Enhanced Contractility following Traumatic Brain Injury:
    Christian W Kreipke; Fiscal Year: 2011
    ..While TBI results in three major pathologies, including diffuse axonal injury, brain edema, and hypoperfusion of the brain's parenchyma, this proposal investigates novel methods to increase blood ..
  9. Mechanisms of early brain injury after subarachnoid hemmorrhage
    Guohua Xi; Fiscal Year: 2013
    ..The causes of early brain injury following SAH are complicated including brain edema formation, blood-brain barrier disruption, increased intracranial pressure/brief global cerebral ischemia, and ..
  10. Mechanisms of Hyperbaric Oxygen Induced Brain Protection
    John H Zhang; Fiscal Year: 2013
    ..possible pathways which will provide tolerance against subsequent cerebral ischemia-induced BBB disruption and brain edema. The long term goal of this proposal is to establish HBO-PC as a clinically means to prevent or reduce brain ..
  11. Cerebrovascular Changes in Pregnancy and Hypertension
    Marilyn J Cipolla; Fiscal Year: 2013
    ..pregnancy and hypertension in pregnancy affect the cerebral circulation in a way that promotes hydrostatic brain edema during increased blood pressure...
  12. Angiogenesis-targeting therapy for glioblastoma
    Tracy T Batchelor; Fiscal Year: 2013
    ..benefit in a subset of GBM patients by transient normalization of tumor vessels leading to alleviation of brain edema, reduction in tumor hypoxia and enhanced delivery of temozolomide;2) Imaging and biospecimen markers of ..
  13. Trauma-Induced Astrocyte Swelling/Brain Edema: Role of NKCC
    MICHAEL DAVID NORENBERG; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abstract Brain edema and associated increase in intracranial pressure are major causes of morbidity and mortality in traumatic brain injury (TBI)...
  14. Blood-Brain Barrier Disruption in Blast Neurotrauma
    AMANDA DAWN GAUDREAU-BALDERRAMA; Fiscal Year: 2013
    ..Results will be compared to BBB disruption patterns detected by conventional methods (Evans blue, HRP, brain edema) and correlated with pericapillary ultrastructural pathology and CTE- linked neuropathology...
  15. Increased sodium dependent glucose transport in the ischemic brain
    Thomas J Abbruscato; Fiscal Year: 2013
    ..for each glucose molecule transported, thus having the propensity to contribute to both vasogenic and cellular brain edema, a leading cause of stroke death...
  16. Monoclonal Antibody Drug Development for Alzheimer's Disease
    William M Pardridge; Fiscal Year: 2012
    ..of Abeta amyloid peptides, and this is associated with cerebral micro-hemorrhage in mice and vasogenic brain edema in humans...
  17. Neurovascular Protection for Subarachnoid Hemorrhage
    John H Zhang; Fiscal Year: 2010
    ..Endothelial apoptosis initiates blood-brain barrier (BBB) disruption leading to brain edema, which expands brain volume to increase intracranial pressure, thus decreasing cerebral blood flow, impairing ..
  18. BLOOD-BRAIN BARRIER ION TRANSPORT IN CEREBRAL ISCHEMIA
    MARTHA E O'DONNELL; Fiscal Year: 2013
    ..goal of this project is to identify blood-brain barrier (BBB) ion transporters that mediate ischemia-induced brain edema. During the early hours of ischemic stroke, edema forms in the presence of an intact BBB by a process involving ..
  19. Inhibition of Clostridium perfringens epsilon toxin
    Mark S McClain; Fiscal Year: 2011
    ..Agent, is responsible for a severe, often fatal enterotoxemia characterized by cardiac, pulmonary, kidney, and brain edema. The mechanism by which epsilon toxin acts is incompletely understood...
  20. BLOOD-BRAIN BARRIER ION TRANSPORT IN CEREBRAL ISCHEMIA
    MARTHA E O'DONNELL; Fiscal Year: 2012
    ..goal of this project is to identify blood-brain barrier (BBB) ion transporters that mediate ischemia-induced brain edema. During the early hours of ischemic stroke, edema forms in the presence of an intact BBB by a process involving ..
  21. Testing tobacco smoke toxicity at the blood-brain barrier
    Luca Cucullo; Fiscal Year: 2013
    ..be used to complement the results in vitro and assess the likelihood and magnitude of secondary brain injury (brain edema) caused by TS exposure (from regular and "reduced-exposure") in synergism with temporary loss of blood flow...
  22. Binge alcohol-induced neurodegeneration and omega-3 DHA Protection
    Michael A Collins; Fiscal Year: 2012
    ..70-120 mM) cause hippocampal/cortical neurodegeneration that (a) is not typically excitotoxic;(b) entails brain edema (diuretics prevent the edema and neurodamage);(c) involves oxidative stress (antioxidants neuroprotect);and (d) ..
  23. Plasmalemma permeability and necroptosis: New targets for intracerebral hemo
    Michael J Whalen; Fiscal Year: 2013
    ..VA64 administration reduces blood brain barrier damage, brain edema, cell death, and motor dysfunction after CCI, and reseals injured cells and reduces BBB damage after ..
  24. Neuroprotection from hyperammonemia: small molecule screen
    Mendel Tuchman; Fiscal Year: 2013
    ..therapies are mainly targeted at reducing blood ammonia levels and although they can fervent death from brain edema, they are inefficient at reducing or preventing brain damage...
  25. Novel NMDA Antagonists to Treat Stroke
    Bhaumik B Patel; Fiscal Year: 2013
    ..In these studies, we will investigate the relationship between behavior, cell survival (TTC staining) and brain edema. Also, since the most feared complication of tPA therapy is intracerebral hemorrhage, we will investigate ..
  26. A rapid microfluidic P.O.C CNS biomarker platform to predict delayed HICP onset.
    SOMASUNDAR PRASAD GABBITA; Fiscal Year: 2012
    ..changes in serum biomarker levels employing the [unreadable]fSPIA POC method and correlate it to changes in brain edema at later time point in rats with severe TBI...
  27. Deferoxamine therapy for intracerebral hemorrhage
    Guohua Xi; Fiscal Year: 2010
    ..In a well-characterized rat model of ICH, deferoxamine will be given systemically. Brain edema formation, brain atrophy and neurological deficits will be examined as endpoints...
  28. Real-time Diffuse near-IR Optical Tomography with EEG Recordings
    Mark Farber; Fiscal Year: 2010
    ..In the future, this work can have applications in the study of ADHD, epilepsy, Alzheimer's Disease, stroke, brain edema, and meningeal hemorrhages.
  29. MATERNAL DEHYDRATION--FETAL/AMNIOTIC FLUID HOMEOSTASIS
    Michael Ross; Fiscal Year: 2002
    ..Secondly, in studies of fetal safety, we will determine if fetal brain edema and/or loss of brain electrolytes are induced by hyponatremia...
  30. CD47 and hematoma clearance in intracerebral hemorrhage
    Ya Hua; Fiscal Year: 2013
    ..After an ICH, lysis of erythrocytes in the hematoma results in brain edema formation, neuronal death and neurological deficits...
  31. DIURETIC PROTECTION FROM ALCOHOL INDUCED BRAIN DAMAGE
    Michael Collins; Fiscal Year: 1999
    ..significantly reduced alcohol-induced cortical neurodegeneration by 75-85 percent as it prevented the brain edema and electrolyte accumulation...
  32. Cell Volume Regulation in Neurons and Glia
    FRANCISCO ALVAREZ LEEFMANS; Fiscal Year: 2006
    ..of the intracellular milieu, causing osmotic disturbances in organ function that may be lethal, such as brain edema. Brain cells face unique and potentially severe challenges for cell volume homeostasis...
  33. VASCULAR PERMEABILITY AND BRAIN EDEMA IN BRAIN ABSCESS
    Warren Lo; Fiscal Year: 1992
    ..b>Brain edema is a serious complication of diseases such as abscess, meningitis, and tumors, but the mechanisms producing ..
  34. Regulation of neural cell volume by thrombin receptors
    Tooba Cheema; Fiscal Year: 2006
    ..For the rational design of therapeutic agents in the treatment of brain edema, both the identification of receptors that regulate VSOAC and the elucidation of signal transduction pathways ..
  35. ISCHEMIA AND CEREBRAL BLOOD VOLUME IN HUMAN HEAD INJURY
    J Muizelaar; Fiscal Year: 1993
    ..pathophysiology of increased ICP and brain stiffness will lead to more rational therapy aimed at either reduce brain edema or cerebral vascular engorgement...
  36. AMINO ACID TRANSPORT IN HYPERAMMONEMIC CONDITIONS
    James Olson; Fiscal Year: 1993
    ..This research project will investigate the role that amino acid transport plays in the development of regional brain edema and in the regulation of brain water content during HE...
  37. 5-Lipoxygenase inhibition as an adjuvant glioma therapy
    Glen Stevens; Fiscal Year: 2005
    ..is accompanied by elevated eicosanoid production and this is thought to be responsible for the peritumoral brain edema that develops in these patients...
  38. ORNITHINE DECARBOXYLASE AND ISCHEMIC BRAIN EDEMA
    Robert Dempsey; Fiscal Year: 1999
    ..Completion of these studies will increase our understanding of the regulation of the harmful and beneficial metabolic events after transient cerebral ischemia which influence outcome. ..
  39. AGONISTS AND ANTAGONISTS OF VASOPRESSIN AND OXYTOCIN
    Maurice Manning; Fiscal Year: 2006
    ..of the syndrome of inappropriate secretion of the antidiuretic hormone (SIADH), congestive heart failure and brain edema. In addition, to their value as tocolytic agents for the treatment of premature labor, OT antagonists may also ..
  40. Role of NADPH Oxidase in ICH-Induced Brain Injury
    Jiping Tang; Fiscal Year: 2006
    ..Early brain injury after ICH is known to involve brain edema, disruption of the blood-brain barrier (BBB) and neurological deficits...
  41. MOLECULAR MECHANISMS OF BLOOD-BRAIN BARRIER DYSFUNCTION
    Harold Koenig; Fiscal Year: 1991
    ..These studies have a direct impact on the basic mechanisms underlying vasogenic brain edema and its treatment. 1...
  42. BLOOD TO BRAIN SODIUM TRANSPORT IN ISCHEMIC BRAIN EDEMA
    STEVEN ENNIS; Fiscal Year: 1999
    DESCRIPTION (Investigator's Abstract): Despite the major clinical importance of brain edema, most treatments remain non-specific and directed at reducing elevated lntracranial pressure rather than inhibiting edema formation...
  43. Side-by-side comparison of blood-brain barrier models
    Edward Rapp; Fiscal Year: 2006
    ..g., brain tumors, ischemia, hypoxia, brain edema, multiple sclerosis, and meningitis) and issues related to bio-defense...
  44. Inhibitors to Clostridium perfrigens epsilon toxin
    MARK MCCLAIN; Fiscal Year: 2007
    ..Agent, is responsible for a severe, often fatal enterotoxemia characterized by cardiac, pulmonary, kidney, and brain edema. The mechanism by which epsilon toxin acts is incompletely understood...
  45. Diffuse optical imaging of intracranial pressure changes
    Gary Strangman; Fiscal Year: 2004
    ..poses a significant risk in patients with traumatic brain injury, intracranial hemorrhage, massive stroke, and brain edema from multiple causes...
  46. Safety and Tolerability of Deferoxamine in Acute Cerebral Hemorrhage
    Magdy H Selim; Fiscal Year: 2010
    ..breakdown and subsequent iron accumulation in the brain play a role in mediating secondary neuronal injury and brain edema after intracerebral hemorrhage (ICH);and that treatment with iron chelators, such as deferoxamine (DFO), ..
  47. INTRACRANIAL PRESSURE GRADIENTS AND BRAIN EDEMA
    Julian Hoff; Fiscal Year: 1980
    This project focuses upon the role of hydrostatic pressure gradients in the formation and resolution of brain edema in experimental animals...
  48. PATHOPHYSIOLOGY OF EXTRACELLULAR MATRIX
    Gary Rosenberg; Fiscal Year: 2000
    ..Inhibition of the metalloproteinases reduces the initial opening of the BBB and brain edema at 24 hours...
  49. IN VITRO BLOOD BRAIN BARRIER
    Steven Moore; Fiscal Year: 1990
    ..Knowledge of cerebrovascular eicosanoid metabolism will then be utilized to assess its effects on the in vitro model of the blood brain barrier developed earlier...
  50. VASOGENIC BRAIN EDEMA IN ISCHEMIC STROKE
    Chung Hsu; Fiscal Year: 1999
    DESCRIPTION (Investigator's Abstract): Evolving brain edema after focal cerebral ischemia is associated with a post ischemic inflammatory response...
  51. CLINIC PATHOPHYSIOLOGY OF ACUTE BRAIN INJURY
    Michael Diringer; Fiscal Year: 2006
    ..Diringer and Robert Grubb will investigate the pathophysiological effects of mannitol and hypertonic saline on brain edema due to ischemic stroke and head trauma...
  52. CLINIC PATHOPHYSIOLOGY OF ACUTE BRAIN INJURY
    Michael Diringer; Fiscal Year: 2007
    ..Diringer and Robert Grubb will investigate the pathophysiological effects of mannitol and hypertonic saline on brain edema due to ischemic stroke and head trauma...
  53. ANALYSIS OF 3 CARDIAC NA,K- TPASE A-SUBUNIT ISOFORMS
    Nelson Ruiz Opazo; Fiscal Year: 1991
    ..It has also been implicated in cardiovascular hypertension, cardiac hypertrophy, brain edema, cystic fibrosis, and autohemolytic red cell membrane diseases...
  54. MECHANISMS OF CYTOTOXIC BRAIN EDEMA
    James Olson; Fiscal Year: 1993
    DESCRIPTION (Adapted from Investigator's Abstract): Brain edema is a critical factor contributing to the mortality and morbidity of individuals with a wide variety of pathologic conditions...
  55. LEUKOTRIENE MODULATION OF THE BLOOD BARRIER IN TUMORS
    Keith Black; Fiscal Year: 1992
    ..Potentially, 5-LO inhibitors could be utilized in the treatment of vasogenic brain edema associated with brain tumors...
  56. NA, K-ATPASE--MOLECULAR GENETICS & ROLE IN HYPERTENSION
    VICTORIA HERRERA; Fiscal Year: 1991
    ..It has also been implicated in hypertension, brain edema and ischemia, manic depression, hepatic failure, ulcerative colitis, diabetic peripheral neuropathy, cystic ..
  57. THE EFFECT OF APOE ON OUTCOMES IN TBI ADULTS
    Yvette Conley; Fiscal Year: 2003
    ..for ApoE (APOE) has been linked to microtubule regeneration and permeability within the neuron contributing to brain edema, which plays a major role in outcomes after TBI...
  58. MECHANISMS OF CELLULAR TAURINE TRANSPORT IN BRAIN EDEMA
    James Olson; Fiscal Year: 2001
    DESCRIPTION (Adapted from applicant's abstract): Cytotoxic brain edema is a serious complication of several clinical conditions including stroke, liver failure and traumatic brain injury and is characterized by swelling of astrocytes ..
  59. TISSUE ULTRAFILTRATION AS A TREATMENT FOR CEREBRAL EDEMA
    Richard Sutton; Fiscal Year: 2001
    ..The proposed research will develop a novel tissue ultrafiltration (TUF) therapy for use in humans with brain edema. Bench studies will identify materials (ultrafiltration fibers, bonding agents, supports) and operational ..
  60. ESA, a Novel Anti-inflammation Agent
    Lurong Zhang; Fiscal Year: 2005
    ..and late soft tissue fibrosis, and EsA was as effective as dexamethasone at reducing radiation-induced brain edema. Side effects were similar or less than Celebrex(r)...
  61. TISSUE WATER MEASUREMENTS OF BRAIN EDEMA WITH MRI
    Weili Lin; Fiscal Year: 1999
    ..In general, therapeutic approaches to brain edema require an understanding of both the location and magnitude of disturbances in intracranial volume homeostasis...
  62. Acute astrocyte pathology after traumatic brain injury
    Bruce Lyeth; Fiscal Year: 2006
    ..in vivo therapeutic studies we will measure astrocyte and neuronal viability using anatomical markers, measure brain edema using magnetic resonance imaging, and measure functional outcome using behavioral measures of sensorimotor ..
  63. Diabetes and Stroke: A Role for the Blood CNS Barriers
    RICHARD EGLETON; Fiscal Year: 2007
    ..One of the major factors in stroke progression and damage is brain edema formation...