Genomes and Genes
Summary: A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
Publications338 found, 100 shown here
- Effect of brain death on gene expression and tissue activation in human donor kidneysWillemijn N Nijboer
Surgery Research Laboratory, University Hospital Groningen, Groningen, The Netherlands
Transplantation 78:978-86. 2004..Research outcomes and clinical donor parameters were then linked to outcome data after transplantation...
- Evidence-based guideline update: determining brain death in adults: report of the Quality Standards Subcommittee of the American Academy of NeurologyEelco F M Wijdicks
Division of Critical Care Neurology, Mayo Clinic, Rochester, MN, USA
Neurology 74:1911-8. 2010..guideline with regard to the following questions: Are there patients who fulfill the clinical criteria of brain death who recover neurologic function? What is an adequate observation period to ensure that cessation of neurologic ..
- Hypoglycemia, functional brain failure, and brain deathPhilip E Cryer
Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Invest 117:868-70. 2007..Rarely, profound hypoglycemia causes brain death that is not the result of fuel deprivation per se...
- Favorable short-term outcome of transplanted hearts selected from marginal donors by pharmacological stress echocardiographyTonino Bombardini
Institute of Clinical Physiology, National Research Council, Pisa, Italy
J Am Soc Echocardiogr 24:353-62. 2011..The aim of this study was to establish the feasibility of an approach based on pharmacologic stress echocardiography as a gatekeeper for extended heart donor criteria...
- Increased plasma interleukin-6 in donors is associated with lower recipient hospital-free survival after cadaveric organ transplantationRaghavan Murugan
CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 36:1810-6. 2008b>Brain death induces a massive inflammatory response. However, the influence of this inflammatory response on organ procurement, transplantation, and recipient outcome is unknown...
- Diffusion-weighted imaging findings in brain deathHakan Selcuk
Department of Radiology, Division of Neuroradiology, Bakirkoy State Hospital, KMP Istanbul 34300, Turkey
Neuroradiology 54:547-54. 2012The purpose of the present study was to determine the role of diffusion-weighted imaging (DWI) and to investigate the use of DWI in the diagnosis of brain death (BD).
- Early donor management increases the retrieval rate of lungs for transplantationRajamiyer V Venkateswaran
Department of Cardiothoracic Surgery Heart and Lung Transplantation Unit, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom
Ann Thorac Surg 85:278-86; discussion 286. 2008..Lung transplantation activity is frustrated by donor lung availability. We sought to examine the effect of active donor management and hormone administration on pulmonary function and yield in cadaveric heart-beating potential lung donors...
- Organ-specific regulation of pro-inflammatory molecules in heart, lung, and kidney following brain deathChristian A Skrabal
Michael E DeBakey Department of Surgery, Division of Transplant Surgery and Assist Devices, Baylor College of Medicine, Houston, Texas, USA
J Surg Res 123:118-25. 2005Nonspecific inflammatory events following brain death may increase the intensity of the immunological host response...
- Brain death induces apoptosis in donor liver of the ratJoost A B van der Hoeven
Department of Surgery, University Hospital, Groningen, The Netherlands
Transplantation 76:1150-4. 2003..that this is caused by induction of apoptosis and inflammation of the potential graft because of the phase of brain death (BD) in the cadaveric donor that predisposes for additional transplant injury...
- Pulmonary transplantation: the role of brain death in donor lung injuryVassilios S Avlonitis
School of Surgical and Reproductive Sciences Surgery, Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom
Transplantation 75:1928-33. 2003..There is evidence that the lung is injured in the donor by the process of brain death and often is made unusable or fails posttransplantation after amplification of the injury by the process of ..
- Sumoylation of hypoxia-inducible factor-1α ameliorates failure of brain stem cardiovascular regulation in experimental brain deathJulie Y H Chan
Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China
PLoS ONE 6:e17375. 2011One aspect of brain death is cardiovascular deregulation because asystole invariably occurs shortly after its diagnosis...
- Machine perfusion versus cold storage for preservation of kidneys from expanded criteria donors after brain deathJürgen Treckmann
Clinic for General, Visceral and Transplantation Surgery, University Hospital Essen, Hufelandstrasse 55, Germany
Transpl Int 24:548-54. 2011..3% vs. 80.2%, P=0.02). In the present study, MP preservation clearly reduced the risk of DGF and improved 1-year graft survival and function in ECD kidneys. (Current Controlled Trials number: ISRCTN83876362)...
- Current situation of donation after circulatory death in European countriesBeatriz Dominguez-Gil
Organizacion Nacional de Trasplantes, Madrid, Spain
Transpl Int 24:676-86. 2011..During 2000-2009, as DCD increased, donation after brain death (DBD) decreased about 20% in the three countries with a predominant controlled DCD activity, while DBD had ..
- Brain death and its implications for management of the potential organ donorJ F Bugge
Division of Anesthesia and Intensive Care, Rikshospitalet, Oslo University Hospital, Oslo, Norway
Acta Anaesthesiol Scand 53:1239-50. 2009The systemic physiologic changes that occur during and after brain death affect all organs suitable for transplantation...
- Medical management to optimize donor organ potential: review of the literatureDemetrios J Kutsogiannis
Division of Critical Care Medicine and Public Health Sciences, University of Alberta, Edmonton, Alberta, Canada
Can J Anaesth 53:820-30. 2006..The purpose of this literature review is to provide updated recommendations for the contemporary management of organ donors after the neurological determination of death in order to maximize the probability of recipient graft survival...
- Selective 4 vessels angiography in brain death: a retrospective studyMartin Savard
Département des Sciences Neurologiques, Centre Hospitalier Affilie Universitaire De Quebec, Hopital de l Enfant Jesus, Universite Laval, Quebec, Quebec, Canada
Can J Neurol Sci 37:492-7. 2010In Canada, ancillary tests, such as selective four vessels angiography (S4VA), are sometimes necessary for brain death (BD) diagnosis when the clinical exam cannot be completed or confounding factors are present...
- Single brain death examination is equivalent to dual brain death examinationsPanayiotis N Varelas
Department of Neurology, Henry Ford Hospital, Detroit, MI, USA
Neurocrit Care 15:547-53. 2011Although the new Practice Parameters for brain death support a single examination, there is paucity of data comparing its impact to dual brain death (DBD) examinations.
- Crosstalk between complement and Toll-like receptor activation in relation to donor brain death and renal ischemia-reperfusion injuryJeffrey Damman
Surgery Nephrology, University Medical Center Groningen, Groningen, The Netherlands Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Am J Transplant 11:660-9. 2011..complement C3 can also be upregulated and activated in the kidney before transplantation as a direct result of brain death (BD) in the donor...
- Second brain death examination may negatively affect organ donationD Lustbader
New York University School of Medicine, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030, USA
Neurology 76:119-24. 2011Little is known about the impact of the requirement for a second brain death examination on organ donation. In New York State, 2 examinations 6 hours apart have been recommended by a Department of Health panel.
- Decision making by relatives about brain death organ donation: an integrative reviewJack de Groot
Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Transplantation 93:1196-211. 2012..We explored the decision making of the relatives of potential brain-dead donors, its evaluation, and the factors influencing decision making...
- Computed tomographic angiography and perfusion in the diagnosis of brain deathR Bohatyrewicz
Pomeranian Medical University Szczecin, Poland
Transplant Proc 42:3941-6. 2010According to Polish brain death (BD) criteria, instrumental confirmatory tests should be used in certain clinical situations, particularly any case for which clinical examinations seem inadequate...
- Local renal complement C3 induction by donor brain death is associated with reduced renal allograft function after transplantationJeffrey Damman
Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands
Nephrol Dial Transplant 26:2345-54. 2011..The aim of this translational study was to investigate the expression of renal acute phase proteins (APPs) following brain death (BD) and to assess the association with renal allograft outcome after transplantation.
- Confirmatory tests in the diagnosis of brain death: comparison between SPECT and contrast angiographyMarina Munari
Department of Pharmacology and Anesthesiology, University Hospital of Padua, Padova, Italy
Crit Care Med 33:2068-73. 2005Cerebral blood flow tests have increasingly been advocated for the confirmation of brain death (BD). Four-vessel angiography has been considered the most reliable investigation in the diagnosis of BD for >30 yrs, but it is invasive...
- Brain death worldwide: accepted fact but no global consensus in diagnostic criteriaEelco F M Wijdicks
Department of Neurology, Neurological and Neurosurgical Intensive Care Unit, Mayo Medical Center, Rochester, MN, USA
Neurology 58:20-5. 2002To survey brain death criteria throughout the world.
- Systemic complement activation in deceased donors is associated with acute rejection after renal transplantation in the recipientJeffrey Damman
Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands
Transplantation 92:163-9. 2011..In this study, we analyzed the effect of systemic complement activation in deceased donors before transplantation of their kidneys on posttransplant outcome in the recipient...
- Brain death induces renal expression of heme oxygenase-1 and heat shock protein 70Leon F A van Dullemen
Department of Surgery, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
J Transl Med 11:22. 2013..We studied the role of stress-inducible genes Heme Oxygenase-1 (HO-1), HSP27, HSP40, and HSP70 in the kidney following a 4 hour period of brain death.
- Intraoperative catecholamine release in brain-dead organ donors is not suppressed by administration of fentanylR D Fitzgerald
Ludwig Boltzmann Institute for Economics of Medicine in Anaesthesia and Intensive Care, Vienna, Austria
Eur J Anaesthesiol 20:952-6. 2003..Our hypothesis was that inhibition of pain by fentanyl would inhibit such catecholamine release...
- Should ancillary brain blood flow analyses play a larger role in the neurological determination of death?Derek J Roberts
Department of Surgery, University of Calgary and the Foothills Medical Centre, Calgary, AB, Canada
Can J Anaesth 57:927-35. 2010..We present two patients who regained spontaneous respiration following clinical neurological determination of death (NDD) while ancillary radiological imaging demonstrated brain blood flow...
- Brain death and its influence on the lungs of the donor: how is it prevented?K Faropoulos
Neurosurgery Department, University Hospital of Patras, University Campus, Rio, Patras Achaia 26504, Greece
Transplant Proc 41:4114-9. 2009..One possible solution to this problem may be the use of grafts from brain-dead patients. Sadly brain death is followed by devastating hemodynamic, inflammatory, and neurohumoral reactions in the potential donor which ..
- Glucocorticoids alter the balance between pro- and anti-inflammatory mediators in the myocardium in a porcine model of brain deathKelly M McLean
Division of Cardiothoracic Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Heart Lung Transplant 26:78-84. 2007Cardiac dysfunction after brain death (BD) limits donors for cardiac transplantation. Glucocorticoids ameliorate brain death-induced donor heart dysfunction...
- Is the increase in DCD organ donors in the United Kingdom contributing to a decline in DBD donors?Dominic M Summers
Department of Surgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Transplantation 90:1506-10. 2010Organ donation after brain death (DBD) has declined in the United Kingdom, whereas donation after cardiac death (DCD) has increased markedly...
- Donation after circulatory death: burying the dead donor ruleDavid Rodríguez-Arias
Universidad del Pais Vasco EHU
Am J Bioeth 11:36-43. 2011....
- A systematic review and meta-analysis of clinical trials of thyroid hormone administration to brain dead potential organ donorsPeter S Macdonald
Heart and Lung Transplant Unit, St Vincent s Hospital, Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia
Crit Care Med 40:1635-44. 2012..To review all published clinical studies of thyroid hormone administration to brain-dead potential organ donors...
- Donor intervention and organ preservation: where is the science and what are the obstacles?S Feng
University of California San Francisco, San Francisco, CA, USA
Am J Transplant 10:1155-62. 2010..Although the basic science dissecting the complex processes of brain death and ischemia/reperfusion injury is replete with exciting discoveries, the clinical science investigating donor ..
- Brain death: can it be resuscitated?D Alan Shewmon
David Geffen School of Medicine at the University of California Los Angeles, USA
Issues Law Med 25:3-14. 2009....
- Organ yield from deceased donors: initial experience of an organ procurement unit in IranSeyed Mohammad Kazemeyni
Department of Urology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Arch Iran Med 12:170-2. 2009..The average of harvested organs was 3.06 per donor and four organs per month. The main cause of brain death was head trauma (n=33, 72%)...
- Traumatic memories of relatives regarding brain death, request for organ donation and interactions with professionals in the ICUA Kesselring
Institute of Nursing Science, University Hospital Basel, Switzerland
Am J Transplant 7:211-7. 2007Little is known about the memories of relatives after they have been confronted with the brain death of a loved one and the request for organ donation...
- Organ donation and time to procurement: late is not too lateKenji Inaba
Division of Trauma and Surgical Critical Care, University of Southern California, 1200 North State Street, Room CL5100, Los Angeles, CA 90033 4525, USA
J Trauma 68:1362-6. 2010No consensus exists as to the maximal period of time allowable after brain death (BD) before organ procurement rates begin to deteriorate. The aim of this study was to examine organ procurement rates as a function of time after BD.
- Immune status and apoptosis activation during brain deathChristophe Adrie
Intensive Care Unit, Delafontaine Hospital, Saint Denis, France
Shock 33:353-62. 2010..the role of the inflammatory status and apoptosis activation in the development of organ dysfunction after brain death using plasma assays and macroarray analysis on skeletal muscle biopsies to look for evidence of remote tissue ..
- Brain death revisited: it is not 'complete death' according to Islamic sourcesAhmet Bedir
Harran University, Faculty of Divinity, Department of Tafsîr Islamic Exegesis, Sanliurfa, Turkey
J Med Ethics 37:290-4. 2011..Cessation of breathing means leaving of the soul from the body. Those who agree on the diagnosis of brain death may not able to agree unanimously on the rules that lay down such diagnosis...
- Prolonged and profound therapeutic hypothermia for the treatment of "brain death" after a suicidal intoxication. Challenging conventional wisdomsPaul E Marik
EVMS Internal Medicine, Norfolk, VA 2350, USA
Am J Emerg Med 28:258.e1-4. 2010..Despite aggressive supportive care, the patient progressed to what appeared to be clinical brain death. At this point, the patient was managed with therapeutic hypothermia for 36 hours...
- Are recent defences of the brain death concept adequate?Ari Joffe
Stollery Children s Hospital, University of Alberta, Edmonton, Alberta, Canada
Bioethics 24:47-53. 2010b>Brain death is accepted in most countries as death. The rationales to explain why brain death is death are surprisingly problematic...
- Heme oxygenase-1 plays a pro-life role in experimental brain stem death via nitric oxide synthase I/protein kinase G signaling at rostral ventrolateral medullaKuang Yu Dai
Center for Translational Research in Biomedical Sciences, Chang Gung Memorial, Hospital Kaohsiung Medical Center, Kaohsiung County 83301, Taiwan
J Biomed Sci 17:72. 2010....
- Donor brain death predisposes human kidney grafts to a proinflammatory reaction after transplantationD K de Vries
Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
Am J Transplant 11:1064-70. 2011Donor brain death has profound effects on post-transplantation graft function and survival. We hypothesized that changes initiated in the donor influence the graft's response to ischemia and reperfusion...
- The case against confirmatory tests for determining brain death in adultsEelco F M Wijdicks
Division of Critical Care Neurology, Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Neurology 75:77-83. 2010The determination of brain death is based on a comprehensive clinical assessment...
- Effects of brain death and hemodynamic status on function and immunologic activation of the potential donor liver in the ratJ A van der Hoeven
Departments of Surgery, Biological Psychiatry, and Clinical Immunology, Groningen University Hospital, Groningen, The Netherlands
Ann Surg 232:804-13. 2000To assess the effect on the function and immunologic status of potential donor livers of the duration of brain death combined with the presence and absence of hemodynamic instability in the donor.
- Amelioration of central cardiovascular regulatory dysfunction by tropomyocin receptor kinase B in a mevinphos intoxication model of brain stem deathS H H Chan
Center for Translational Researchin Biomedical Sciences, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
Br J Pharmacol 164:2015-28. 2011..We investigated the role of tropomyocin receptor kinase B (TrkB) and its downstream signalling pathways in the rostral ventrolateral medulla (RVLM) during experimental brain stem death...
- New insights on brain stem death: from bedside to benchJulie Y H Chan
Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81346, Taiwan, ROC
Prog Neurobiol 77:396-425. 2005..Thus, identification of additional programs in the RVLM and delineation of their regulatory mechanisms should shed new lights on future directions for clinical management of life-and-death...
- Brain death activates donor organs and is associated with a worse I/R injury after liver transplantationS Weiss
Department of Surgery, Charite, Campus Virchow Clinic, Universitatsmedizin Berlin, Germany
Am J Transplant 7:1584-93. 2007The majority of transplants are derived from donors who suffered from brain injury. There is evidence that brain death causes inflammatory changes in the donor...
- Hemodynamic resuscitation with arginine vasopressin reduces lung injury after brain death in the transplant donorAnthony J Rostron
Applied Immunology and Transplant Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
Transplantation 85:597-606. 2008The autonomic storm accompanying brain death leads to neurogenic pulmonary edema and triggers development of systemic and pulmonary inflammatory responses...
- Synergistic effects of brain death and liver steatosis on the hepatic microcirculationKazuhiko Yamagami
Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Munich, Germany
Transplantation 80:500-5. 2005..Steatosis and brain death have been perceived as independent risk factors, but they may synergistically target the hepatic ..
- Hypoxia-inducible factor 1/heme oxygenase 1 cascade as upstream signals in the prolife role of heat shock protein 70 at rostral ventrolateral medulla during experimental brain stem deathAlice Y W Chang
Center for Translational Research in Biomedical Sciences, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung County, Republic of China
Shock 32:651-8. 2009....
- Stress echocardiography as a gatekeeper to donation in aged marginal donor hearts: anatomic and pathologic correlations of abnormal stress echocardiography resultsOrnella Leone
Department of Pathology, University of Bologna, Bologna, Italy
J Heart Lung Transplant 28:1141-9. 2009..echocardiography is highly accurate in identifying prognostically significant coronary artery disease, but brain death and catecholamine storm in potential heart donors may substantially alter the cardiovascular response to stress...
- Role of heme oxygenase-1 in transplantationRobert Ollinger
Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Innsbruck, Austria
Transpl Int 23:1071-81. 2010..In transplantation, HO-1 is overexpressed in organs during brain death, when undergoing ischemic damage and rejection...
- Critical care management of potential organ donors: our current standardC Dictus
Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany
Clin Transplant 23:2-9. 2009..The pathophysiological changes following brain death entail a high incidence of complications including hemodynamic instability, endocrine and metabolic ..
- Extracorporeal support for organ donation after cardiac death effectively expands the donor poolJoseph F Magliocca
Department of Surgery, The University of Wisconsin School of Medicine, Madison WI, USA
J Trauma 58:1095-101; discussion 1101-2. 2005..Study parameters included increase in number of donors and organs, types of organs procured, and viability of kidneys transplanted...
- Relationship between duration of brain death and hemodynamic (in)stability on progressive dysfunction and increased immunologic activation of donor kidneysJoost A B van der Hoeven
Department of Surgery, University Hospital Groningen, Groningen, The Netherlands
Kidney Int 64:1874-82. 2003..Recently, evidence has been put forward that brain death has significant effects on the donor organ quality...
- Systemic inflammation in the brain-dead organ donorA Barklin
Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Noerrebrogade 44, Aarhus C, Denmark
Acta Anaesthesiol Scand 53:425-35. 2009b>Brain death itself impairs organ function in the potential donor, thereby limiting the number of suitable organs for transplantation...
- Heat shock protein 60 or 70 activates nitric-oxide synthase (NOS) I- and inhibits NOS II-associated signaling and depresses the mitochondrial apoptotic cascade during brain stem deathJulie Y H Chan
Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81346, Taiwan
J Biol Chem 282:4585-600. 2007..In addition, HSP60 exerts its effects against apoptosis by blunting Mev-induced activation of the Bax/cytochrome c/caspase-3 cascade...
- What can be learned from brain-death models?J Pratschke
Department of Visceral and Transplantation Surgery, Universitatsmedizin Berlin, Campus Virchow, Augustenburgerplatz 1, D 13353 Berlin, Germany
Transpl Int 18:15-21. 2005b>Brain death of the donor is an important risk factor influencing graft outcome. In addition to its nonspecific effects, it potentiates graft immunogenicity and increases host alloresponsiveness...
- The circulatory-respiratory determination of death in organ donationJames L Bernat
Neurology Department, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
Crit Care Med 38:963-70. 2010..We studied circulatory-respiratory death determination to clarify its concept, practice, and application to innovative circulatory determination of death protocols...
- Severe brain injury to neurological determination of death: Canadian forum recommendationsSam D Shemie
Division of Pediatric Critical Care, Montreal Children s Hospital, McGill University Health Centre, Montreal, Que
CMAJ 174:S1-13. 2006
- Hormonal therapy of the brain-dead organ donor: experimental and clinical studiesDmitri Novitzky
Division of Cardiac Surgery, University of South Florida, Tampa, FL, USA
Transplantation 82:1396-401. 2006Experiments in Cape Town in the 1980s demonstrated that acute brain death is followed by massive catecholamine release resulting in systemic hypertension, acute left ventricular failure, and multiple cardiac arrhythmias along with ..
- Aggressive pharmacologic donor management results in more transplanted organsJohn D Rosendale
Research Department, United Network for Organ Sharing, Richmond, VA 23218, USA
Transplantation 75:482-7. 2003b>Brain death results in adverse pathophysiologic effects in many cadaveric donors, resulting in cardiovascular instability and poor organ perfusion...
- Scientific, legal, and ethical challenges of end-of-life organ procurement in emergency medicineMohamed Y Rady
Department of Critical Care Medicine, Mayo Clinic, Phoenix, AZ 85054, USA
Resuscitation 81:1069-78. 2010....
- Brain death in combination with warm ischemic stress during isolation procedures induces the expression of crucial inflammatory mediators in the isolated isletsYukihiko Saito
Division of Advanced Surgical Science and Technology, Tohoku University, Sendai, Japan
Cell Transplant 19:775-82. 2010..Because the key steps that directly induce TF and MCP-1 remain to be determined, we focused on the influence of brain death (BD) on TF and MCP-1 expression in the pancreatic tissues and isolated islets using a rodent model...
- Donor pretreatment with carbamylated erythropoietin in a brain death model reduces inflammation more effectively than erythropoietin while preserving renal functionWillemijn N Nijboer
Surgery Research Laboratory, Department of Surgery, University Medical Center Groningen, University of Groningen, The Netherlands
Crit Care Med 38:1155-61. 2010We hypothesized that donor treatment of deceased brain dead donors would lead to a decrease in inflammatory responses seen in brain death and lead to a restoration of kidney function.
- Is stress cardiomyopathy the underlying cause of ventricular dysfunction associated with brain death?Marius Berman
Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, UK
J Heart Lung Transplant 29:957-65. 2010..This myocardial insult appears in association with brain death in the donor and follows a "catecholamine storm" associated with a rapidly rising intracranial pressure...
- Acute necrotizing encephalopathy progressing to brain death in a pediatric patient with novel influenza A (H1N1) infectionAlexandra Martin
Pediatric Residency Program, Department of Pediatrics, University of Tennessee College of Medicine Chattanooga, Chattanooga, TN 37403, USA
Clin Infect Dis 50:e50-2. 2010We report a case of encephalopathy progressing to brain death in a pediatric patient with confirmed infection with novel influenza H1N1...
- Death and organ procurement: public beliefs and attitudesLaura A Siminoff
Department of Bioethics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4976, USA
Soc Sci Med 59:2325-34. 2004While brain death and the dead donor rule (patients must not be killed by organ retrieval) have been clinically and legally accepted in the US as a prerequisite to organ removal, there is little data about public attitudes and beliefs ..
- Donating hearts after cardiac death--reversing the irreversibleRobert M Veatch
Kennedy Institute of Ethics, Georgetown University, Washington, DC, USA
N Engl J Med 359:672-3. 2008
- Organ donations and unused potential donations in traumatic brain injury, subarachnoid haemorrhage and intracerebral haemorrhageErwin J O Kompanje
Department of Neurosurgery, Erasmus MC University Medical Center Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
Intensive Care Med 32:217-22. 2006To obtain insight into the occurrence of brain death and the potential for brain dead and controlled non-heart-beating organ donors (CNHB) in patients with traumatic brain injury (TBI), subarachnoid haemorrhage (SAH) and intracerebral ..
- ASTS recommended practice guidelines for controlled donation after cardiac death organ procurement and transplantationD J Reich
Drexel University College of Medicine, Philadelphia, PA, USA
Am J Transplant 9:2004-11. 2009..after cardiac death (DCD) offers the family and the patient with a hopeless prognosis the option to donate when brain death criteria will not be met. Although DCD is increasing, this endeavor is still in the midst of development...
- Reliability of computed tomographic angiography in the diagnosis of brain deathJ C Combes
Department of Anesthesiology and Intensive Care, Dijon University Hospital, General Hospital, Dijon, France
Transplant Proc 39:16-20. 2007This study examined the validity of cerebral computed tomographic (CT) angiography in the diagnosis of brain death (BD) compared with conventional cerebral angiography.
- Donor cause of brain death and related time intervals: does it affect outcome after lung transplantation?Shana Wauters
Laboratory of Experimental Thoracic Surgery, Catholic University Leuven, Leuven, Belgium
Eur J Cardiothorac Surg 39:e68-76. 2011It remains uncertain whether donor cause of brain death (DCBD) affects survival and freedom from bronchiolitis obliterans syndrome (BOS) after lung transplantation (LTx)...
- Brain death: the challenges of translating medical science into Islamic bioethical discourseAasim I Padela
Program on Medicine and Religion, Section of General Internal Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA
Med Law 31:433-50. 2012Islamic ethico-legal assessments of brain death are varied and controversial...
- Guidelines for maintenance of adult patients with brain death and potential for multiple organ donations: the Task Force of the Brazilian Association of Intensive Medicine the Brazilian Association of Organs Transplantation, and the Transplantation CenterG A Westphal
Brazilian Association of Intensive Medicine, the Brazilian Association of Organ Transplants ABTO, and the Transplantation Center of Santa Catarina SC Tx, Santa Catarina, Brazil
Transplant Proc 44:2260-7. 2012..In this scenario, the intensivist occupies a prominent position as one of the professionals that first has a chance to identify brain death and to be responsible for the maintenance of the potential deceased donor.
- Distinct transcriptional changes in donor kidneys upon brain death induction in rats: insights in the processes of brain deathTheo A Schuurs
Department of Surgery, University Hospital Groningen, Groningen, The Netherlands
Am J Transplant 4:1972-81. 2004b>Brain death affects hormone regulation, inflammatory reactivity and hemodynamic stability...
- Studies of isolated global brain ischaemia: I. Overview of irreversible brain injury and evolution of a new concept - redefining the time of brain deathBradley S Allen
Department of Surgery, University of California, Los Angeles, CA, USA
Eur J Cardiothorac Surg 41:1132-7. 2012..These findings may introduce innovative management approaches for sudden death, and perhaps stroke, because the brain is completely salvageable following ischaemic times thought previously to produce infarction...
- Brain tissue oxygen tension in clinical brain death: a case seriesMichael Louis Smith
Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Neurol Res 29:755-9. 2007b>Brain death is a clinical diagnosis often confirmed with supplementary tests. In this study, we examined the relationship between brain death and the partial pressure of brain tissue oxygen (PbtO(2))...
- Myocardial dysfunction associated with brain death: clinical, echocardiographic, and pathologic featuresK S Dujardin
Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
J Heart Lung Transplant 20:350-7. 2001..the prevalence and characteristics of myocardial dysfunction seen in the context of brain-injury-related brain death and to compare these abnormalities with myocardial pathologic changes...
- Controversies of diffusion weighted imaging in the diagnosis of brain deathMichael Luchtmann
Department of Neurosurgery, Otto von Guericke University Magdeburg, Leipziger Str 44, 39120, Magdeburg
J Neuroimaging 23:463-8. 2013Imaging techniques as confirmatory tests may add safety to the diagnosis of brain death, but are partly not accepted either because they are too invasive, such as conventional arterial angiography, or because there is still lack of ..
- Influence of donor brain death on chronic rejection of renal transplants in ratsJ Pratschke
Surgical Research Laboratory and Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
J Am Soc Nephrol 12:2474-81. 2001..regardless of relationship with the host, are consistently superior to those of cadavers suggests an effect of brain death (BD) on organ quality and function...
- Standardized experimental brain death model for studies of intracranial dynamics, organ preservation, and organ transplantation in the pigKarlis Purins
Department of Neuroscience, Section of Neurosurgery, Uppsala University Hospital, Uppsala University, Uppsala, Sweden
Crit Care Med 39:512-7. 2011b>Brain death impairs organ function and outcome after transplantation. There is a need for a brain death model to allow studies of organ viability and preservation...
- Reversible brain death after cardiopulmonary arrest and induced hypothermiaAdam C Webb
Department of Neurology, Neuroscience Critical Care, Emory University School of Medicine, Atlanta, GA, USA
Crit Care Med 39:1538-42. 2011To describe a patient with transient reversal of findings of brain death after cardiopulmonary arrest and attempted therapeutic hypothermia.
- Hormonal changes in brain death and immune activation in the donorK Lopau
Medizinische Universitätsklinik Würzburg, Abteilung Nephrologie, Germany
Transpl Int 13:S282-5. 2000Kidneys obtained from brain dead donors show inferior graft survival compared to living donation. The effects of brain death itself are thought to be partly responsible for these results...
- The influence of brain death on liver in ratsS J Zhang
Institute of Transplantation, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, People s Republic of China
Transplant Proc 36:1925-7. 2004Donor brain death produces functional and morphological changes in peripheral organs. We examined the influence of brain death on liver function.
- Contribution of MRI and MR angiography in early diagnosis of brain deathA H Karantanas
Department of CT MRI, Larissa General Hospital, 1 Tsakalof Street, 412 21 Larissa, Greece
Eur Radiol 12:2710-6. 2002..was to investigate whether the findings of MR imaging and MR angiography could accurately and early diagnose brain death in comatose patients. Thirty comatose patients were studied with MRI and MR arteriography...
- Brain death and the cervical spinal cord: a confounding factor for the clinical examinationA R Joffe
Department of Pediatrics, 3A3 07 Stollery Children s Hospital, 8440 112 Street, University of Alberta, Edmonton, Alberta, Canada T6G 2B7
Spinal Cord 48:2-9. 2010..This study is a systematic review...
- Brain death induces inflammation in the donor intestineLyan G Koudstaal
Surgical Research Laboratory, Department of Surgery, University Medical Center Groningen, University of Groningen, The Netherlands
Transplantation 86:148-54. 2008b>Brain death donors are frequently used for transplantation. Previous studies showed that brain death (BD) negatively affects the immunological and inflammatory status of both liver and kidney...
- Carbon monoxide inhalation decreased lung injury via anti-inflammatory and anti-apoptotic effects in brain death ratsHuacheng Zhou
Department of Anesthesiology, The Second Affiliated Hospital, Harbin Medical University, Harbin, China
Exp Biol Med (Maywood) 235:1236-43. 2010b>Brain death (BD) induces acute lung injury and makes donor lungs unfit for transplantation. Carbon monoxide (CO) inhalation at 50-500 ppm exerts anti-inflammatory and anti-apoptosis effects in several lung injury models...
- Pediatric heart transplantation after declaration of cardiocirculatory deathMark M Boucek
Department of Pediatrics, Joe DiMaggio Children s Hospital, Hollywood, FL 33021, USA
N Engl J Med 359:709-14. 2008..Mortality while awaiting a transplant is an order of magnitude higher in infants than in adults, and donors who died from cardiocirculatory causes offer an opportunity to decrease this waiting-list mortality...
- Total brain death: a reply to Alan ShewmonPatrick Lee
Institute of Bioethics, Franciscan University of Steubenville, Steubenville, Ohio 43952, USA
Bioethics 26:275-84. 2012D. Alan Shewmon has advanced a well-documented challenge to the widely accepted total brain death criterion for death of the human being...
- Disassociation between intracranial and systemic temperatures as an early sign of brain deathK N Fountas
Department of Neurosurgery, The Medical Center of Central Georgia, Mercer University School of Medicine, Macon, Georgia, USA
J Neurosurg Anesthesiol 15:87-9. 2003..21-5.18 hours), prior to any changes in intracranial and cerebral perfusion pressures. Reversal of the disassociation between intraventricular and systemic temperatures may be an early marker of patients with a poor prognosis...
- L-arginine improves endothelial and myocardial function after brain deathGabor Szabo
Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
Transplantation 82:108-12. 2006Recently, we showed that brain death (BD) leads to a severe impairment of endothelial function.
- Enhanced isolated pancreatic islet recovery and functionality in rats by 17beta-estradiol treatment of brain death donorsDevin E Eckhoff
Division of Transplantation and Transplant Center, Department of Surgery Prosthodontics and Biomaterials, University of Alabama School of Dentistry, Birmingham, AL, USA
Surgery 136:336-45. 2004Current isolation techniques recover only 20% to 50% of the pancreatic islets. Brain death (BD) is characterized by activation of proinflammatory cytokines (PICs) with reduced islet yields and functionality...
- Brain death provokes very acute alteration in myocardial morphology detected by echocardiography: preventive effect of beta-blockersRene Ferrera
INSERM, U886, Universite de Lyon, Universite Lyon 1, Lyon, France
Transpl Int 24:300-6. 2011Our objective was to evaluate immediate acute changes in myocardial function during the autonomic storm of brain death (BD)...
- Donation after cardiac death: a 29-year experienceJanet M Bellingham
Division of Organ Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 7375, USA
Surgery 150:692-702. 2011..To report the long-term outcomes of 1218 organs transplanted from donation after cardiac death (DCD) donors from January 1980 through December 2008...
- Sympathetic cardiovascular hyperactivity precedes brain deathHarald Marthol
Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
Clin Auton Res 20:363-9. 2010The time preceding brain death is associated with complex dysregulation including autonomic dysfunction that may compromise organ perfusion, thus inducing final organ failure...
- Hemodynamic and oxygen transport patterns after head trauma and brain death: implications for management of the organ donorHoward Belzberg
Department of Surgery, Los Angeles County University of Southern California Medical Center, CA 90033, USA
J Trauma 63:1032-42. 2007....
- An ethical dilemma in the ICU: retrieving semen from a brain dead patientBernadetta Moser
Wien Klin Wochenschr 119:438-9. 2007
- Role of complement in brain death induced injury to donor heartsStephen Tomlinson; Fiscal Year: 2010b>Brain death (BD) and ischemia reperfusion injury (IRI) are unavoidable consequences of heart transplantation...
- Extracorporeal Support for Emergent (Uncontrolled) Donation Following Cardiac DeaShawn J Pelletier; Fiscal Year: 2010..function and maintained until they are procured in a semi-elective fashion, similar to donation following brain death (DBD)...
- Imaging Nonlinear Control of the Pulmonary Circulation with Proton MRISusan R Hopkins; Fiscal Year: 2013..shown that nonlinear control of heart rate of pre-term infants increased with maturation, and was lost in brain death suggesting that nonlinear control is a critical feature of a healthy human cardiovascular system...
- More and Better Lungs: Ex-Vivo Perfusion of Lungs from Non-Heart-Beating DonorsThomas M Egan; Fiscal Year: 2013..organ donors - individuals who sustain a lethal brain injury, but who are incubated and ventilated before brain death occurs...
- Exploring the Physiology of Short-term Control of Cerebral Blood Flow in HumansJ Andrew Taylor; Fiscal Year: 2011..flow constant over a wide range of blood pressures is critical to health since too little flow could cause brain death whereas too much could raise the pressure on the brain...
- Role of Endogenous Toll-Like Receptor Ligands in Allospecific T Cell ActivationTODD VICTOR BRENNAN; Fiscal Year: 2013..donor organs are subjected to many potential sources of sterile tissue injury, including: donor brain death, prolonged ischemia time, reperfusion injury, surgical trauma, and immunological injury...
- CTRIP Ex-vivo perfusion and ventilation of lungs to assess transplant suitabilityThomas M Egan; Fiscal Year: 2010..organ donors - individuals who sustain a lethal brain injury, but who are intubated and ventilated before brain death occurs...
- AMELIORATION OF THE DELETERIOUS EFFECTS OF DONOR BRAIN DEATHLUCIA MADARIAGA; Fiscal Year: 2013..We hypothesize that the inflammatory state associated with donor brain death prevents the induction of tolerance in this preclinical model...
- Ex vivo perfusion in a lung box for rehabilitation of donor lungsVictor E Laubach; Fiscal Year: 2013..Donor lungs are typically retrieved from individuals after brain death;however, there is renewed interest in utilizing non-heart- beating donor (NHBD) lungs retrieved after cardiac ..
- Donation After Cardiac Death for Isolated Pancreatic Is*Luis Fernandez; Fiscal Year: 2006..a comprehensive assessment of human islets from DCD donors and compare them to islets from Donation after Brain Death (DBD) donors...
- VENTRICULAR DYSFUNCTION AFTER SUBARACHNOID HEMORRHAGEJonathan Zaroff; Fiscal Year: 2004..3. Cause of donor brain death (SAH vs...
- COGNITIVE RETRAINING IN SUDDEN CARDIAC ARREST SURVIVORSMARY SAUVE; Fiscal Year: 2000..A wide range of neurological sequelae ranging from mild intellectual impairment to brain death have been reported...
- RENAL EFFECTS OF BRAIN DEATH AND THE MARGINAL DONORNicholas Tilney; Fiscal Year: 1999..In the initial series of experiments, the effects of brain death, altered systemic hemodynamics and their correction by pressor on the expression of cell adhesion molecules and ..
- Physician Peer Minority Organ Donation Education ModelAkinlolu Ojo; Fiscal Year: 2006..physician leaders as instructors/role models for physicians in selected specialties who regularly encounter brain death and thus, potential cadaveric organ donors (Emergency Medicine, Neurosurgery and Trauma); (2) to deliver a 2-..
- ORGAN PRESERVATION FOR TRANSPLANTATIONJAMES SOUTHARD; Fiscal Year: 2003..Specific Aim 1 will determine the relationship between brain death (BD) and transplant viability, including variables such as time of BD, preservation method, and length of ..
- DYNAMIC IMMUNE ASSESSMENT IN TRANSPLANT PATIENTSCharles Orosz; Fiscal Year: 2003..be measured as a functional index that summates the impact of all peritransplant insults to the graft (donor brain death and medication', ischemia/reperfusion injury, etc.)...
- Strategy for islet recovery, functionality & engraftmentJuan Contreras; Fiscal Year: 2006..The proposed studies are expected to yield novel information about the effects of BD on isolated islet biology and to develop potential targets for therapeutic intervention, thereby enhancing the efficacy of PIT as a cure for diabetes. ..
- Effects of brain-death on islet recovery and functional*John Thompson; Fiscal Year: 2006..Overall, these studies will bring novel information about human islet biology and will provide c potential therapeutic strategy to enhance the therapeutic efficacy of PIT as a cure for diabetes. ..
- Hormonal Therapy to Increase Islet Recovery/Engraftment From Multiorgan DonorsJuan Contreras; Fiscal Year: 2008..Studies demonstrated organ deterioration following brain death (BD) by multiple interrelated events, including the effects of cerebral injury, homodynamic instability that ..
- A new approach to xenotransplantation in primateJuan Contreras; Fiscal Year: 2005..The research proposed in this grant will provide significant information to the xenotransplant research and the potential use of porcine islets as an alternative to human tissue for pancreatic islet transplantation. ..
- Toward Optimal End-of-Life Care in the PICURobert Truog; Fiscal Year: 2010....
- Molecular Surgeon Symposium on Pancreatic CancerF Brunicardi; Fiscal Year: 2003..All talks will be video-taped and presented at our "The Molecular Surgeon" website for general public access. This website has been established since first symposium in 1999. ..
- Biological Markers of Recovery for the KidneyJohn A Kellum; Fiscal Year: 2010..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
- FAMILY CONFLICT AND DECISION MAKING FOR ADVANCED CANCERLaura Siminoff; Fiscal Year: 2004..Cut-off scores will be provided for classifying concordant and discordant families. In addition, rich and detailed descriptive information about the family treatment decision-making process will be provided. ..
- Post Traumatic Nonconvulsive Epileptiform ActivityPaul Vespa; Fiscal Year: 2005..The hypothesis and unique approach come at a crucial time of failed clinical trials and address an important new therapeutic target. ..
- EXCITOTOXICITY IN CIRCULATORY ARREST--BRAIN INJURYWilliam Baumgartner; Fiscal Year: 2007....
- CORTICAL MECHANISMS IN PERCEPTION AND BEHAVIORCharles Gross; Fiscal Year: 2003..The proposed research may also contribute to the development of visual and limb prostheses and artificial devices for object manipulation. ..
- Molecular Dissection of Melatonin Synthesis In VivoJimo Borjigin; Fiscal Year: 2003....
- ISCHEMIC INJURY IN CADAVER DONORS FOR LUNG TRANSPLANTThomas Egan; Fiscal Year: 2003..This will facilitate the introduction of lung retrieval for transplant from NHBDs, which has the potential to extend the lives of thousands of Americans suffering with a variety of lung diseases. ..
- THERAPEUTIC RESEARCH CONSENT--EMPIRICAL/ETHICAL ANALYSISLaura Siminoff; Fiscal Year: 2001....
- Appraisal Delay and Disparities in Timely Cancer DiagnosisLaura A Siminoff; Fiscal Year: 2010....
- MRS Detects Metabolic Dysfunction after Brain InjuryPaul Vespa; Fiscal Year: 2009..The knowledge from the proposed studies will have widespread application to critical care of neurotrauma patients. ..
- Ventilator-induced diaphragm dysfunctionSANFORD NO MIDDLE NAME LEVINE; Fiscal Year: 2010..Moreover, these studies may directly lead to therapy for this newly recognized but relatively common disease of diaphragm muscle. ..
- Understanding Consent to Tissue DonationLaura Siminoff; Fiscal Year: 2005..This study will be the first to comprehensively examine consent to tissue donation. ..
- Patient-Centered Approach to Advance Care PlanningKARIN KIRCHHOFF; Fiscal Year: 2006..abstract_text> ..
- Cerebral Edema in Pediatric Diabetic KetoacidosisMONICA VAVILALA; Fiscal Year: 2006..unreadable] [unreadable]..
- Hemodynamics and Outcome in Pediatric Brain InjuryMONICA VAVILALA; Fiscal Year: 2007..The proposed research will be carried out at the University of Washington, well-known known for mentored patient-oriented research. ..
- TLR4 Signaling in Myocardial Ischemia-Reperfusion InjuryEdward Verrier; Fiscal Year: 2008..Our intention is to focus on the role TLR4 and its signaling pathways in I/R injury to more precisely define therapeutic targets that are specific to myocardial I/R injury. ..
- Thromboregulation to Prevent Thrombotic MicroangiopathyDavid Cooper; Fiscal Year: 2008..It is anticipated that these approaches will abrogate the development of TM and allow long-term survival of pig organs in baboons. ..
- Tolerance to Carbohydrate Antigens in TransplantationDavid Cooper; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Enhancing Advance Care Planning in Diverse Elders with Limited LiteracyREBECCA SUDORE; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Systems Engineering of Pheresis Intervention for SepsisJohn Kellum; Fiscal Year: 2009..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
- PUBLIC ATTITUDES TOWARDS DEATH AND ORGAN PROCUREMENTLaura Siminoff; Fiscal Year: 2001..Since 1968, the concept of brain death and the "dead donor rule" have guided the determination of death for the purposes of organ procurement...
- Ethical Issues in Behavioral Health ResearchJames DuBois; Fiscal Year: 2004..The Center for Health Care Ethics at Saint Louis University and the Missouri Institute of Mental Health are committed to sustaining the course beyond year 3. ..