brain death

Summary

Summary: A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)

Top Publications

  1. ncbi Effect of brain death on gene expression and tissue activation in human donor kidneys
    Willemijn N Nijboer
    Surgery Research Laboratory, University Hospital Groningen, Groningen, The Netherlands
    Transplantation 78:978-86. 2004
  2. ncbi Evidence-based guideline update: determining brain death in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology
    Eelco F M Wijdicks
    Division of Critical Care Neurology, Mayo Clinic, Rochester, MN, USA
    Neurology 74:1911-8. 2010
  3. pmc Hypoglycemia, functional brain failure, and brain death
    Philip E Cryer
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 117:868-70. 2007
  4. ncbi Favorable short-term outcome of transplanted hearts selected from marginal donors by pharmacological stress echocardiography
    Tonino Bombardini
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    J Am Soc Echocardiogr 24:353-62. 2011
  5. ncbi Increased plasma interleukin-6 in donors is associated with lower recipient hospital-free survival after cadaveric organ transplantation
    Raghavan Murugan
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:1810-6. 2008
  6. ncbi Diffusion-weighted imaging findings in brain death
    Hakan Selcuk
    Department of Radiology, Division of Neuroradiology, Bakirkoy State Hospital, KMP Istanbul 34300, Turkey
    Neuroradiology 54:547-54. 2012
  7. ncbi Early donor management increases the retrieval rate of lungs for transplantation
    Rajamiyer V Venkateswaran
    Department of Cardiothoracic Surgery Heart and Lung Transplantation Unit, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom
    Ann Thorac Surg 85:278-86; discussion 286. 2008
  8. ncbi Organ-specific regulation of pro-inflammatory molecules in heart, lung, and kidney following brain death
    Christian A Skrabal
    Michael E DeBakey Department of Surgery, Division of Transplant Surgery and Assist Devices, Baylor College of Medicine, Houston, Texas, USA
    J Surg Res 123:118-25. 2005
  9. ncbi Brain death induces apoptosis in donor liver of the rat
    Joost A B van der Hoeven
    Department of Surgery, University Hospital, Groningen, The Netherlands
    Transplantation 76:1150-4. 2003
  10. ncbi Pulmonary transplantation: the role of brain death in donor lung injury
    Vassilios S Avlonitis
    School of Surgical and Reproductive Sciences Surgery, Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Transplantation 75:1928-33. 2003

Detail Information

Publications338 found, 100 shown here

  1. ncbi Effect of brain death on gene expression and tissue activation in human donor kidneys
    Willemijn N Nijboer
    Surgery Research Laboratory, University Hospital Groningen, Groningen, The Netherlands
    Transplantation 78:978-86. 2004
    ..Research outcomes and clinical donor parameters were then linked to outcome data after transplantation...
  2. ncbi Evidence-based guideline update: determining brain death in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology
    Eelco F M Wijdicks
    Division of Critical Care Neurology, Mayo Clinic, Rochester, MN, USA
    Neurology 74:1911-8. 2010
    ..guideline with regard to the following questions: Are there patients who fulfill the clinical criteria of brain death who recover neurologic function? What is an adequate observation period to ensure that cessation of neurologic ..
  3. pmc Hypoglycemia, functional brain failure, and brain death
    Philip E Cryer
    Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 117:868-70. 2007
    ..Rarely, profound hypoglycemia causes brain death that is not the result of fuel deprivation per se...
  4. ncbi Favorable short-term outcome of transplanted hearts selected from marginal donors by pharmacological stress echocardiography
    Tonino Bombardini
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    J Am Soc Echocardiogr 24:353-62. 2011
    ..The aim of this study was to establish the feasibility of an approach based on pharmacologic stress echocardiography as a gatekeeper for extended heart donor criteria...
  5. ncbi Increased plasma interleukin-6 in donors is associated with lower recipient hospital-free survival after cadaveric organ transplantation
    Raghavan Murugan
    CRISMA Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 36:1810-6. 2008
    b>Brain death induces a massive inflammatory response. However, the influence of this inflammatory response on organ procurement, transplantation, and recipient outcome is unknown...
  6. ncbi Diffusion-weighted imaging findings in brain death
    Hakan Selcuk
    Department of Radiology, Division of Neuroradiology, Bakirkoy State Hospital, KMP Istanbul 34300, Turkey
    Neuroradiology 54:547-54. 2012
    The purpose of the present study was to determine the role of diffusion-weighted imaging (DWI) and to investigate the use of DWI in the diagnosis of brain death (BD).
  7. ncbi Early donor management increases the retrieval rate of lungs for transplantation
    Rajamiyer V Venkateswaran
    Department of Cardiothoracic Surgery Heart and Lung Transplantation Unit, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom
    Ann Thorac Surg 85:278-86; discussion 286. 2008
    ..Lung transplantation activity is frustrated by donor lung availability. We sought to examine the effect of active donor management and hormone administration on pulmonary function and yield in cadaveric heart-beating potential lung donors...
  8. ncbi Organ-specific regulation of pro-inflammatory molecules in heart, lung, and kidney following brain death
    Christian A Skrabal
    Michael E DeBakey Department of Surgery, Division of Transplant Surgery and Assist Devices, Baylor College of Medicine, Houston, Texas, USA
    J Surg Res 123:118-25. 2005
    Nonspecific inflammatory events following brain death may increase the intensity of the immunological host response...
  9. ncbi Brain death induces apoptosis in donor liver of the rat
    Joost A B van der Hoeven
    Department of Surgery, University Hospital, Groningen, The Netherlands
    Transplantation 76:1150-4. 2003
    ..that this is caused by induction of apoptosis and inflammation of the potential graft because of the phase of brain death (BD) in the cadaveric donor that predisposes for additional transplant injury...
  10. ncbi Pulmonary transplantation: the role of brain death in donor lung injury
    Vassilios S Avlonitis
    School of Surgical and Reproductive Sciences Surgery, Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Transplantation 75:1928-33. 2003
    ..There is evidence that the lung is injured in the donor by the process of brain death and often is made unusable or fails posttransplantation after amplification of the injury by the process of ..
  11. pmc Sumoylation of hypoxia-inducible factor-1α ameliorates failure of brain stem cardiovascular regulation in experimental brain death
    Julie Y H Chan
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, Republic of China
    PLoS ONE 6:e17375. 2011
    One aspect of brain death is cardiovascular deregulation because asystole invariably occurs shortly after its diagnosis...
  12. ncbi Machine perfusion versus cold storage for preservation of kidneys from expanded criteria donors after brain death
    Jürgen Treckmann
    Clinic for General, Visceral and Transplantation Surgery, University Hospital Essen, Hufelandstrasse 55, Germany
    Transpl Int 24:548-54. 2011
    ..3% vs. 80.2%, P=0.02). In the present study, MP preservation clearly reduced the risk of DGF and improved 1-year graft survival and function in ECD kidneys. (Current Controlled Trials number: ISRCTN83876362)...
  13. ncbi Current situation of donation after circulatory death in European countries
    Beatriz Dominguez-Gil
    Organizacion Nacional de Trasplantes, Madrid, Spain
    Transpl Int 24:676-86. 2011
    ..During 2000-2009, as DCD increased, donation after brain death (DBD) decreased about 20% in the three countries with a predominant controlled DCD activity, while DBD had ..
  14. ncbi Brain death and its implications for management of the potential organ donor
    J F Bugge
    Division of Anesthesia and Intensive Care, Rikshospitalet, Oslo University Hospital, Oslo, Norway
    Acta Anaesthesiol Scand 53:1239-50. 2009
    The systemic physiologic changes that occur during and after brain death affect all organs suitable for transplantation...
  15. ncbi Medical management to optimize donor organ potential: review of the literature
    Demetrios J Kutsogiannis
    Division of Critical Care Medicine and Public Health Sciences, University of Alberta, Edmonton, Alberta, Canada
    Can J Anaesth 53:820-30. 2006
    ..The purpose of this literature review is to provide updated recommendations for the contemporary management of organ donors after the neurological determination of death in order to maximize the probability of recipient graft survival...
  16. ncbi Selective 4 vessels angiography in brain death: a retrospective study
    Martin Savard
    Département des Sciences Neurologiques, Centre Hospitalier Affilie Universitaire De Quebec, Hopital de l Enfant Jesus, Universite Laval, Quebec, Quebec, Canada
    Can J Neurol Sci 37:492-7. 2010
    In Canada, ancillary tests, such as selective four vessels angiography (S4VA), are sometimes necessary for brain death (BD) diagnosis when the clinical exam cannot be completed or confounding factors are present...
  17. ncbi Single brain death examination is equivalent to dual brain death examinations
    Panayiotis N Varelas
    Department of Neurology, Henry Ford Hospital, Detroit, MI, USA
    Neurocrit Care 15:547-53. 2011
    Although the new Practice Parameters for brain death support a single examination, there is paucity of data comparing its impact to dual brain death (DBD) examinations.
  18. ncbi Crosstalk between complement and Toll-like receptor activation in relation to donor brain death and renal ischemia-reperfusion injury
    Jeffrey Damman
    Surgery Nephrology, University Medical Center Groningen, Groningen, The Netherlands Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Transplant 11:660-9. 2011
    ..complement C3 can also be upregulated and activated in the kidney before transplantation as a direct result of brain death (BD) in the donor...
  19. ncbi Second brain death examination may negatively affect organ donation
    D Lustbader
    New York University School of Medicine, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030, USA
    Neurology 76:119-24. 2011
    Little is known about the impact of the requirement for a second brain death examination on organ donation. In New York State, 2 examinations 6 hours apart have been recommended by a Department of Health panel.
  20. ncbi Decision making by relatives about brain death organ donation: an integrative review
    Jack de Groot
    Nijmegen Centre for Evidence Based Practice, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Transplantation 93:1196-211. 2012
    ..We explored the decision making of the relatives of potential brain-dead donors, its evaluation, and the factors influencing decision making...
  21. ncbi Computed tomographic angiography and perfusion in the diagnosis of brain death
    R Bohatyrewicz
    Pomeranian Medical University Szczecin, Poland
    Transplant Proc 42:3941-6. 2010
    According to Polish brain death (BD) criteria, instrumental confirmatory tests should be used in certain clinical situations, particularly any case for which clinical examinations seem inadequate...
  22. ncbi Local renal complement C3 induction by donor brain death is associated with reduced renal allograft function after transplantation
    Jeffrey Damman
    Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 26:2345-54. 2011
    ..The aim of this translational study was to investigate the expression of renal acute phase proteins (APPs) following brain death (BD) and to assess the association with renal allograft outcome after transplantation.
  23. ncbi Confirmatory tests in the diagnosis of brain death: comparison between SPECT and contrast angiography
    Marina Munari
    Department of Pharmacology and Anesthesiology, University Hospital of Padua, Padova, Italy
    Crit Care Med 33:2068-73. 2005
    Cerebral blood flow tests have increasingly been advocated for the confirmation of brain death (BD). Four-vessel angiography has been considered the most reliable investigation in the diagnosis of BD for >30 yrs, but it is invasive...
  24. ncbi Brain death worldwide: accepted fact but no global consensus in diagnostic criteria
    Eelco F M Wijdicks
    Department of Neurology, Neurological and Neurosurgical Intensive Care Unit, Mayo Medical Center, Rochester, MN, USA
    Neurology 58:20-5. 2002
    To survey brain death criteria throughout the world.
  25. ncbi Systemic complement activation in deceased donors is associated with acute rejection after renal transplantation in the recipient
    Jeffrey Damman
    Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 92:163-9. 2011
    ..In this study, we analyzed the effect of systemic complement activation in deceased donors before transplantation of their kidneys on posttransplant outcome in the recipient...
  26. pmc Brain death induces renal expression of heme oxygenase-1 and heat shock protein 70
    Leon F A van Dullemen
    Department of Surgery, University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    J Transl Med 11:22. 2013
    ..We studied the role of stress-inducible genes Heme Oxygenase-1 (HO-1), HSP27, HSP40, and HSP70 in the kidney following a 4 hour period of brain death.
  27. ncbi Intraoperative catecholamine release in brain-dead organ donors is not suppressed by administration of fentanyl
    R D Fitzgerald
    Ludwig Boltzmann Institute for Economics of Medicine in Anaesthesia and Intensive Care, Vienna, Austria
    Eur J Anaesthesiol 20:952-6. 2003
    ..Our hypothesis was that inhibition of pain by fentanyl would inhibit such catecholamine release...
  28. ncbi Should ancillary brain blood flow analyses play a larger role in the neurological determination of death?
    Derek J Roberts
    Department of Surgery, University of Calgary and the Foothills Medical Centre, Calgary, AB, Canada
    Can J Anaesth 57:927-35. 2010
    ..We present two patients who regained spontaneous respiration following clinical neurological determination of death (NDD) while ancillary radiological imaging demonstrated brain blood flow...
  29. ncbi Brain death and its influence on the lungs of the donor: how is it prevented?
    K Faropoulos
    Neurosurgery Department, University Hospital of Patras, University Campus, Rio, Patras Achaia 26504, Greece
    Transplant Proc 41:4114-9. 2009
    ..One possible solution to this problem may be the use of grafts from brain-dead patients. Sadly brain death is followed by devastating hemodynamic, inflammatory, and neurohumoral reactions in the potential donor which ..
  30. ncbi Glucocorticoids alter the balance between pro- and anti-inflammatory mediators in the myocardium in a porcine model of brain death
    Kelly M McLean
    Division of Cardiothoracic Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Heart Lung Transplant 26:78-84. 2007
    Cardiac dysfunction after brain death (BD) limits donors for cardiac transplantation. Glucocorticoids ameliorate brain death-induced donor heart dysfunction...
  31. ncbi Is the increase in DCD organ donors in the United Kingdom contributing to a decline in DBD donors?
    Dominic M Summers
    Department of Surgery, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Transplantation 90:1506-10. 2010
    Organ donation after brain death (DBD) has declined in the United Kingdom, whereas donation after cardiac death (DCD) has increased markedly...
  32. ncbi Donation after circulatory death: burying the dead donor rule
    David Rodríguez-Arias
    Universidad del Pais Vasco EHU
    Am J Bioeth 11:36-43. 2011
    ....
  33. ncbi A systematic review and meta-analysis of clinical trials of thyroid hormone administration to brain dead potential organ donors
    Peter S Macdonald
    Heart and Lung Transplant Unit, St Vincent s Hospital, Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia
    Crit Care Med 40:1635-44. 2012
    ..To review all published clinical studies of thyroid hormone administration to brain-dead potential organ donors...
  34. ncbi Donor intervention and organ preservation: where is the science and what are the obstacles?
    S Feng
    University of California San Francisco, San Francisco, CA, USA
    Am J Transplant 10:1155-62. 2010
    ..Although the basic science dissecting the complex processes of brain death and ischemia/reperfusion injury is replete with exciting discoveries, the clinical science investigating donor ..
  35. ncbi Brain death: can it be resuscitated?
    D Alan Shewmon
    David Geffen School of Medicine at the University of California Los Angeles, USA
    Issues Law Med 25:3-14. 2009
    ....
  36. ncbi Organ yield from deceased donors: initial experience of an organ procurement unit in Iran
    Seyed Mohammad Kazemeyni
    Department of Urology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Arch Iran Med 12:170-2. 2009
    ..The average of harvested organs was 3.06 per donor and four organs per month. The main cause of brain death was head trauma (n=33, 72%)...
  37. ncbi Traumatic memories of relatives regarding brain death, request for organ donation and interactions with professionals in the ICU
    A Kesselring
    Institute of Nursing Science, University Hospital Basel, Switzerland
    Am J Transplant 7:211-7. 2007
    Little is known about the memories of relatives after they have been confronted with the brain death of a loved one and the request for organ donation...
  38. ncbi Organ donation and time to procurement: late is not too late
    Kenji Inaba
    Division of Trauma and Surgical Critical Care, University of Southern California, 1200 North State Street, Room CL5100, Los Angeles, CA 90033 4525, USA
    J Trauma 68:1362-6. 2010
    No consensus exists as to the maximal period of time allowable after brain death (BD) before organ procurement rates begin to deteriorate. The aim of this study was to examine organ procurement rates as a function of time after BD.
  39. ncbi Immune status and apoptosis activation during brain death
    Christophe Adrie
    Intensive Care Unit, Delafontaine Hospital, Saint Denis, France
    Shock 33:353-62. 2010
    ..the role of the inflammatory status and apoptosis activation in the development of organ dysfunction after brain death using plasma assays and macroarray analysis on skeletal muscle biopsies to look for evidence of remote tissue ..
  40. ncbi Brain death revisited: it is not 'complete death' according to Islamic sources
    Ahmet Bedir
    Harran University, Faculty of Divinity, Department of Tafsîr Islamic Exegesis, Sanliurfa, Turkey
    J Med Ethics 37:290-4. 2011
    ..Cessation of breathing means leaving of the soul from the body. Those who agree on the diagnosis of brain death may not able to agree unanimously on the rules that lay down such diagnosis...
  41. ncbi Prolonged and profound therapeutic hypothermia for the treatment of "brain death" after a suicidal intoxication. Challenging conventional wisdoms
    Paul E Marik
    EVMS Internal Medicine, Norfolk, VA 2350, USA
    Am J Emerg Med 28:258.e1-4. 2010
    ..Despite aggressive supportive care, the patient progressed to what appeared to be clinical brain death. At this point, the patient was managed with therapeutic hypothermia for 36 hours...
  42. ncbi Are recent defences of the brain death concept adequate?
    Ari Joffe
    Stollery Children s Hospital, University of Alberta, Edmonton, Alberta, Canada
    Bioethics 24:47-53. 2010
    b>Brain death is accepted in most countries as death. The rationales to explain why brain death is death are surprisingly problematic...
  43. pmc Heme oxygenase-1 plays a pro-life role in experimental brain stem death via nitric oxide synthase I/protein kinase G signaling at rostral ventrolateral medulla
    Kuang Yu Dai
    Center for Translational Research in Biomedical Sciences, Chang Gung Memorial, Hospital Kaohsiung Medical Center, Kaohsiung County 83301, Taiwan
    J Biomed Sci 17:72. 2010
    ....
  44. ncbi Donor brain death predisposes human kidney grafts to a proinflammatory reaction after transplantation
    D K de Vries
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Am J Transplant 11:1064-70. 2011
    Donor brain death has profound effects on post-transplantation graft function and survival. We hypothesized that changes initiated in the donor influence the graft's response to ischemia and reperfusion...
  45. ncbi The case against confirmatory tests for determining brain death in adults
    Eelco F M Wijdicks
    Division of Critical Care Neurology, Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 75:77-83. 2010
    The determination of brain death is based on a comprehensive clinical assessment...
  46. pmc Effects of brain death and hemodynamic status on function and immunologic activation of the potential donor liver in the rat
    J A van der Hoeven
    Departments of Surgery, Biological Psychiatry, and Clinical Immunology, Groningen University Hospital, Groningen, The Netherlands
    Ann Surg 232:804-13. 2000
    To assess the effect on the function and immunologic status of potential donor livers of the duration of brain death combined with the presence and absence of hemodynamic instability in the donor.
  47. pmc Amelioration of central cardiovascular regulatory dysfunction by tropomyocin receptor kinase B in a mevinphos intoxication model of brain stem death
    S H H Chan
    Center for Translational Researchin Biomedical Sciences, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Br J Pharmacol 164:2015-28. 2011
    ..We investigated the role of tropomyocin receptor kinase B (TrkB) and its downstream signalling pathways in the rostral ventrolateral medulla (RVLM) during experimental brain stem death...
  48. ncbi New insights on brain stem death: from bedside to bench
    Julie Y H Chan
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81346, Taiwan, ROC
    Prog Neurobiol 77:396-425. 2005
    ..Thus, identification of additional programs in the RVLM and delineation of their regulatory mechanisms should shed new lights on future directions for clinical management of life-and-death...
  49. ncbi Brain death activates donor organs and is associated with a worse I/R injury after liver transplantation
    S Weiss
    Department of Surgery, Charite, Campus Virchow Clinic, Universitatsmedizin Berlin, Germany
    Am J Transplant 7:1584-93. 2007
    The majority of transplants are derived from donors who suffered from brain injury. There is evidence that brain death causes inflammatory changes in the donor...
  50. ncbi Hemodynamic resuscitation with arginine vasopressin reduces lung injury after brain death in the transplant donor
    Anthony J Rostron
    Applied Immunology and Transplant Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    Transplantation 85:597-606. 2008
    The autonomic storm accompanying brain death leads to neurogenic pulmonary edema and triggers development of systemic and pulmonary inflammatory responses...
  51. ncbi Synergistic effects of brain death and liver steatosis on the hepatic microcirculation
    Kazuhiko Yamagami
    Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Munich, Germany
    Transplantation 80:500-5. 2005
    ..Steatosis and brain death have been perceived as independent risk factors, but they may synergistically target the hepatic ..
  52. ncbi Hypoxia-inducible factor 1/heme oxygenase 1 cascade as upstream signals in the prolife role of heat shock protein 70 at rostral ventrolateral medulla during experimental brain stem death
    Alice Y W Chang
    Center for Translational Research in Biomedical Sciences, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung County, Republic of China
    Shock 32:651-8. 2009
    ....
  53. ncbi Stress echocardiography as a gatekeeper to donation in aged marginal donor hearts: anatomic and pathologic correlations of abnormal stress echocardiography results
    Ornella Leone
    Department of Pathology, University of Bologna, Bologna, Italy
    J Heart Lung Transplant 28:1141-9. 2009
    ..echocardiography is highly accurate in identifying prognostically significant coronary artery disease, but brain death and catecholamine storm in potential heart donors may substantially alter the cardiovascular response to stress...
  54. ncbi Role of heme oxygenase-1 in transplantation
    Robert Ollinger
    Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Innsbruck, Austria
    Transpl Int 23:1071-81. 2010
    ..In transplantation, HO-1 is overexpressed in organs during brain death, when undergoing ischemic damage and rejection...
  55. ncbi Critical care management of potential organ donors: our current standard
    C Dictus
    Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 23:2-9. 2009
    ..The pathophysiological changes following brain death entail a high incidence of complications including hemodynamic instability, endocrine and metabolic ..
  56. ncbi Extracorporeal support for organ donation after cardiac death effectively expands the donor pool
    Joseph F Magliocca
    Department of Surgery, The University of Wisconsin School of Medicine, Madison WI, USA
    J Trauma 58:1095-101; discussion 1101-2. 2005
    ..Study parameters included increase in number of donors and organs, types of organs procured, and viability of kidneys transplanted...
  57. ncbi Relationship between duration of brain death and hemodynamic (in)stability on progressive dysfunction and increased immunologic activation of donor kidneys
    Joost A B van der Hoeven
    Department of Surgery, University Hospital Groningen, Groningen, The Netherlands
    Kidney Int 64:1874-82. 2003
    ..Recently, evidence has been put forward that brain death has significant effects on the donor organ quality...
  58. ncbi Systemic inflammation in the brain-dead organ donor
    A Barklin
    Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Noerrebrogade 44, Aarhus C, Denmark
    Acta Anaesthesiol Scand 53:425-35. 2009
    b>Brain death itself impairs organ function in the potential donor, thereby limiting the number of suitable organs for transplantation...
  59. ncbi Heat shock protein 60 or 70 activates nitric-oxide synthase (NOS) I- and inhibits NOS II-associated signaling and depresses the mitochondrial apoptotic cascade during brain stem death
    Julie Y H Chan
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81346, Taiwan
    J Biol Chem 282:4585-600. 2007
    ..In addition, HSP60 exerts its effects against apoptosis by blunting Mev-induced activation of the Bax/cytochrome c/caspase-3 cascade...
  60. ncbi What can be learned from brain-death models?
    J Pratschke
    Department of Visceral and Transplantation Surgery, Universitatsmedizin Berlin, Campus Virchow, Augustenburgerplatz 1, D 13353 Berlin, Germany
    Transpl Int 18:15-21. 2005
    b>Brain death of the donor is an important risk factor influencing graft outcome. In addition to its nonspecific effects, it potentiates graft immunogenicity and increases host alloresponsiveness...
  61. ncbi The circulatory-respiratory determination of death in organ donation
    James L Bernat
    Neurology Department, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Crit Care Med 38:963-70. 2010
    ..We studied circulatory-respiratory death determination to clarify its concept, practice, and application to innovative circulatory determination of death protocols...
  62. pmc Severe brain injury to neurological determination of death: Canadian forum recommendations
    Sam D Shemie
    Division of Pediatric Critical Care, Montreal Children s Hospital, McGill University Health Centre, Montreal, Que
    CMAJ 174:S1-13. 2006
  63. ncbi Hormonal therapy of the brain-dead organ donor: experimental and clinical studies
    Dmitri Novitzky
    Division of Cardiac Surgery, University of South Florida, Tampa, FL, USA
    Transplantation 82:1396-401. 2006
    Experiments in Cape Town in the 1980s demonstrated that acute brain death is followed by massive catecholamine release resulting in systemic hypertension, acute left ventricular failure, and multiple cardiac arrhythmias along with ..
  64. ncbi Aggressive pharmacologic donor management results in more transplanted organs
    John D Rosendale
    Research Department, United Network for Organ Sharing, Richmond, VA 23218, USA
    Transplantation 75:482-7. 2003
    b>Brain death results in adverse pathophysiologic effects in many cadaveric donors, resulting in cardiovascular instability and poor organ perfusion...
  65. ncbi Scientific, legal, and ethical challenges of end-of-life organ procurement in emergency medicine
    Mohamed Y Rady
    Department of Critical Care Medicine, Mayo Clinic, Phoenix, AZ 85054, USA
    Resuscitation 81:1069-78. 2010
    ....
  66. ncbi Brain death in combination with warm ischemic stress during isolation procedures induces the expression of crucial inflammatory mediators in the isolated islets
    Yukihiko Saito
    Division of Advanced Surgical Science and Technology, Tohoku University, Sendai, Japan
    Cell Transplant 19:775-82. 2010
    ..Because the key steps that directly induce TF and MCP-1 remain to be determined, we focused on the influence of brain death (BD) on TF and MCP-1 expression in the pancreatic tissues and isolated islets using a rodent model...
  67. ncbi Donor pretreatment with carbamylated erythropoietin in a brain death model reduces inflammation more effectively than erythropoietin while preserving renal function
    Willemijn N Nijboer
    Surgery Research Laboratory, Department of Surgery, University Medical Center Groningen, University of Groningen, The Netherlands
    Crit Care Med 38:1155-61. 2010
    We hypothesized that donor treatment of deceased brain dead donors would lead to a decrease in inflammatory responses seen in brain death and lead to a restoration of kidney function.
  68. ncbi Is stress cardiomyopathy the underlying cause of ventricular dysfunction associated with brain death?
    Marius Berman
    Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, UK
    J Heart Lung Transplant 29:957-65. 2010
    ..This myocardial insult appears in association with brain death in the donor and follows a "catecholamine storm" associated with a rapidly rising intracranial pressure...
  69. ncbi Acute necrotizing encephalopathy progressing to brain death in a pediatric patient with novel influenza A (H1N1) infection
    Alexandra Martin
    Pediatric Residency Program, Department of Pediatrics, University of Tennessee College of Medicine Chattanooga, Chattanooga, TN 37403, USA
    Clin Infect Dis 50:e50-2. 2010
    We report a case of encephalopathy progressing to brain death in a pediatric patient with confirmed infection with novel influenza H1N1...
  70. ncbi Death and organ procurement: public beliefs and attitudes
    Laura A Siminoff
    Department of Bioethics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4976, USA
    Soc Sci Med 59:2325-34. 2004
    While brain death and the dead donor rule (patients must not be killed by organ retrieval) have been clinically and legally accepted in the US as a prerequisite to organ removal, there is little data about public attitudes and beliefs ..
  71. doi Donating hearts after cardiac death--reversing the irreversible
    Robert M Veatch
    Kennedy Institute of Ethics, Georgetown University, Washington, DC, USA
    N Engl J Med 359:672-3. 2008
  72. ncbi Organ donations and unused potential donations in traumatic brain injury, subarachnoid haemorrhage and intracerebral haemorrhage
    Erwin J O Kompanje
    Department of Neurosurgery, Erasmus MC University Medical Center Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Intensive Care Med 32:217-22. 2006
    To obtain insight into the occurrence of brain death and the potential for brain dead and controlled non-heart-beating organ donors (CNHB) in patients with traumatic brain injury (TBI), subarachnoid haemorrhage (SAH) and intracerebral ..
  73. ncbi ASTS recommended practice guidelines for controlled donation after cardiac death organ procurement and transplantation
    D J Reich
    Drexel University College of Medicine, Philadelphia, PA, USA
    Am J Transplant 9:2004-11. 2009
    ..after cardiac death (DCD) offers the family and the patient with a hopeless prognosis the option to donate when brain death criteria will not be met. Although DCD is increasing, this endeavor is still in the midst of development...
  74. ncbi Reliability of computed tomographic angiography in the diagnosis of brain death
    J C Combes
    Department of Anesthesiology and Intensive Care, Dijon University Hospital, General Hospital, Dijon, France
    Transplant Proc 39:16-20. 2007
    This study examined the validity of cerebral computed tomographic (CT) angiography in the diagnosis of brain death (BD) compared with conventional cerebral angiography.
  75. ncbi Donor cause of brain death and related time intervals: does it affect outcome after lung transplantation?
    Shana Wauters
    Laboratory of Experimental Thoracic Surgery, Catholic University Leuven, Leuven, Belgium
    Eur J Cardiothorac Surg 39:e68-76. 2011
    It remains uncertain whether donor cause of brain death (DCBD) affects survival and freedom from bronchiolitis obliterans syndrome (BOS) after lung transplantation (LTx)...
  76. ncbi Brain death: the challenges of translating medical science into Islamic bioethical discourse
    Aasim I Padela
    Program on Medicine and Religion, Section of General Internal Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA
    Med Law 31:433-50. 2012
    Islamic ethico-legal assessments of brain death are varied and controversial...
  77. ncbi Guidelines for maintenance of adult patients with brain death and potential for multiple organ donations: the Task Force of the Brazilian Association of Intensive Medicine the Brazilian Association of Organs Transplantation, and the Transplantation Center
    G A Westphal
    Brazilian Association of Intensive Medicine, the Brazilian Association of Organ Transplants ABTO, and the Transplantation Center of Santa Catarina SC Tx, Santa Catarina, Brazil
    Transplant Proc 44:2260-7. 2012
    ..In this scenario, the intensivist occupies a prominent position as one of the professionals that first has a chance to identify brain death and to be responsible for the maintenance of the potential deceased donor.
  78. ncbi Distinct transcriptional changes in donor kidneys upon brain death induction in rats: insights in the processes of brain death
    Theo A Schuurs
    Department of Surgery, University Hospital Groningen, Groningen, The Netherlands
    Am J Transplant 4:1972-81. 2004
    b>Brain death affects hormone regulation, inflammatory reactivity and hemodynamic stability...
  79. ncbi Studies of isolated global brain ischaemia: I. Overview of irreversible brain injury and evolution of a new concept - redefining the time of brain death
    Bradley S Allen
    Department of Surgery, University of California, Los Angeles, CA, USA
    Eur J Cardiothorac Surg 41:1132-7. 2012
    ..These findings may introduce innovative management approaches for sudden death, and perhaps stroke, because the brain is completely salvageable following ischaemic times thought previously to produce infarction...
  80. ncbi Brain tissue oxygen tension in clinical brain death: a case series
    Michael Louis Smith
    Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurol Res 29:755-9. 2007
    b>Brain death is a clinical diagnosis often confirmed with supplementary tests. In this study, we examined the relationship between brain death and the partial pressure of brain tissue oxygen (PbtO(2))...
  81. ncbi Myocardial dysfunction associated with brain death: clinical, echocardiographic, and pathologic features
    K S Dujardin
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA
    J Heart Lung Transplant 20:350-7. 2001
    ..the prevalence and characteristics of myocardial dysfunction seen in the context of brain-injury-related brain death and to compare these abnormalities with myocardial pathologic changes...
  82. ncbi Controversies of diffusion weighted imaging in the diagnosis of brain death
    Michael Luchtmann
    Department of Neurosurgery, Otto von Guericke University Magdeburg, Leipziger Str 44, 39120, Magdeburg
    J Neuroimaging 23:463-8. 2013
    Imaging techniques as confirmatory tests may add safety to the diagnosis of brain death, but are partly not accepted either because they are too invasive, such as conventional arterial angiography, or because there is still lack of ..
  83. ncbi Influence of donor brain death on chronic rejection of renal transplants in rats
    J Pratschke
    Surgical Research Laboratory and Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 12:2474-81. 2001
    ..regardless of relationship with the host, are consistently superior to those of cadavers suggests an effect of brain death (BD) on organ quality and function...
  84. ncbi Standardized experimental brain death model for studies of intracranial dynamics, organ preservation, and organ transplantation in the pig
    Karlis Purins
    Department of Neuroscience, Section of Neurosurgery, Uppsala University Hospital, Uppsala University, Uppsala, Sweden
    Crit Care Med 39:512-7. 2011
    b>Brain death impairs organ function and outcome after transplantation. There is a need for a brain death model to allow studies of organ viability and preservation...
  85. ncbi Reversible brain death after cardiopulmonary arrest and induced hypothermia
    Adam C Webb
    Department of Neurology, Neuroscience Critical Care, Emory University School of Medicine, Atlanta, GA, USA
    Crit Care Med 39:1538-42. 2011
    To describe a patient with transient reversal of findings of brain death after cardiopulmonary arrest and attempted therapeutic hypothermia.
  86. ncbi Hormonal changes in brain death and immune activation in the donor
    K Lopau
    Medizinische Universitätsklinik Würzburg, Abteilung Nephrologie, Germany
    Transpl Int 13:S282-5. 2000
    Kidneys obtained from brain dead donors show inferior graft survival compared to living donation. The effects of brain death itself are thought to be partly responsible for these results...
  87. ncbi The influence of brain death on liver in rats
    S J Zhang
    Institute of Transplantation, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Transplant Proc 36:1925-7. 2004
    Donor brain death produces functional and morphological changes in peripheral organs. We examined the influence of brain death on liver function.
  88. ncbi Contribution of MRI and MR angiography in early diagnosis of brain death
    A H Karantanas
    Department of CT MRI, Larissa General Hospital, 1 Tsakalof Street, 412 21 Larissa, Greece
    Eur Radiol 12:2710-6. 2002
    ..was to investigate whether the findings of MR imaging and MR angiography could accurately and early diagnose brain death in comatose patients. Thirty comatose patients were studied with MRI and MR arteriography...
  89. ncbi Brain death and the cervical spinal cord: a confounding factor for the clinical examination
    A R Joffe
    Department of Pediatrics, 3A3 07 Stollery Children s Hospital, 8440 112 Street, University of Alberta, Edmonton, Alberta, Canada T6G 2B7
    Spinal Cord 48:2-9. 2010
    ..This study is a systematic review...
  90. ncbi Brain death induces inflammation in the donor intestine
    Lyan G Koudstaal
    Surgical Research Laboratory, Department of Surgery, University Medical Center Groningen, University of Groningen, The Netherlands
    Transplantation 86:148-54. 2008
    b>Brain death donors are frequently used for transplantation. Previous studies showed that brain death (BD) negatively affects the immunological and inflammatory status of both liver and kidney...
  91. ncbi Carbon monoxide inhalation decreased lung injury via anti-inflammatory and anti-apoptotic effects in brain death rats
    Huacheng Zhou
    Department of Anesthesiology, The Second Affiliated Hospital, Harbin Medical University, Harbin, China
    Exp Biol Med (Maywood) 235:1236-43. 2010
    b>Brain death (BD) induces acute lung injury and makes donor lungs unfit for transplantation. Carbon monoxide (CO) inhalation at 50-500 ppm exerts anti-inflammatory and anti-apoptosis effects in several lung injury models...
  92. ncbi Pediatric heart transplantation after declaration of cardiocirculatory death
    Mark M Boucek
    Department of Pediatrics, Joe DiMaggio Children s Hospital, Hollywood, FL 33021, USA
    N Engl J Med 359:709-14. 2008
    ..Mortality while awaiting a transplant is an order of magnitude higher in infants than in adults, and donors who died from cardiocirculatory causes offer an opportunity to decrease this waiting-list mortality...
  93. ncbi Total brain death: a reply to Alan Shewmon
    Patrick Lee
    Institute of Bioethics, Franciscan University of Steubenville, Steubenville, Ohio 43952, USA
    Bioethics 26:275-84. 2012
    D. Alan Shewmon has advanced a well-documented challenge to the widely accepted total brain death criterion for death of the human being...
  94. ncbi Disassociation between intracranial and systemic temperatures as an early sign of brain death
    K N Fountas
    Department of Neurosurgery, The Medical Center of Central Georgia, Mercer University School of Medicine, Macon, Georgia, USA
    J Neurosurg Anesthesiol 15:87-9. 2003
    ..21-5.18 hours), prior to any changes in intracranial and cerebral perfusion pressures. Reversal of the disassociation between intraventricular and systemic temperatures may be an early marker of patients with a poor prognosis...
  95. ncbi L-arginine improves endothelial and myocardial function after brain death
    Gabor Szabo
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    Transplantation 82:108-12. 2006
    Recently, we showed that brain death (BD) leads to a severe impairment of endothelial function.
  96. ncbi Enhanced isolated pancreatic islet recovery and functionality in rats by 17beta-estradiol treatment of brain death donors
    Devin E Eckhoff
    Division of Transplantation and Transplant Center, Department of Surgery Prosthodontics and Biomaterials, University of Alabama School of Dentistry, Birmingham, AL, USA
    Surgery 136:336-45. 2004
    Current isolation techniques recover only 20% to 50% of the pancreatic islets. Brain death (BD) is characterized by activation of proinflammatory cytokines (PICs) with reduced islet yields and functionality...
  97. ncbi Brain death provokes very acute alteration in myocardial morphology detected by echocardiography: preventive effect of beta-blockers
    Rene Ferrera
    INSERM, U886, Universite de Lyon, Universite Lyon 1, Lyon, France
    Transpl Int 24:300-6. 2011
    Our objective was to evaluate immediate acute changes in myocardial function during the autonomic storm of brain death (BD)...
  98. pmc Donation after cardiac death: a 29-year experience
    Janet M Bellingham
    Division of Organ Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 7375, USA
    Surgery 150:692-702. 2011
    ..To report the long-term outcomes of 1218 organs transplanted from donation after cardiac death (DCD) donors from January 1980 through December 2008...
  99. ncbi Sympathetic cardiovascular hyperactivity precedes brain death
    Harald Marthol
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Clin Auton Res 20:363-9. 2010
    The time preceding brain death is associated with complex dysregulation including autonomic dysfunction that may compromise organ perfusion, thus inducing final organ failure...
  100. ncbi Hemodynamic and oxygen transport patterns after head trauma and brain death: implications for management of the organ donor
    Howard Belzberg
    Department of Surgery, Los Angeles County University of Southern California Medical Center, CA 90033, USA
    J Trauma 63:1032-42. 2007
    ....
  101. ncbi An ethical dilemma in the ICU: retrieving semen from a brain dead patient
    Bernadetta Moser
    Wien Klin Wochenschr 119:438-9. 2007

Research Grants44

  1. Role of complement in brain death induced injury to donor hearts
    Stephen Tomlinson; Fiscal Year: 2010
    b>Brain death (BD) and ischemia reperfusion injury (IRI) are unavoidable consequences of heart transplantation...
  2. Extracorporeal Support for Emergent (Uncontrolled) Donation Following Cardiac Dea
    Shawn J Pelletier; Fiscal Year: 2010
    ..function and maintained until they are procured in a semi-elective fashion, similar to donation following brain death (DBD)...
  3. Imaging Nonlinear Control of the Pulmonary Circulation with Proton MRI
    Susan R Hopkins; Fiscal Year: 2013
    ..shown that nonlinear control of heart rate of pre-term infants increased with maturation, and was lost in brain death suggesting that nonlinear control is a critical feature of a healthy human cardiovascular system...
  4. More and Better Lungs: Ex-Vivo Perfusion of Lungs from Non-Heart-Beating Donors
    Thomas M Egan; Fiscal Year: 2013
    ..organ donors - individuals who sustain a lethal brain injury, but who are incubated and ventilated before brain death occurs...
  5. Exploring the Physiology of Short-term Control of Cerebral Blood Flow in Humans
    J Andrew Taylor; Fiscal Year: 2011
    ..flow constant over a wide range of blood pressures is critical to health since too little flow could cause brain death whereas too much could raise the pressure on the brain...
  6. Role of Endogenous Toll-Like Receptor Ligands in Allospecific T Cell Activation
    TODD VICTOR BRENNAN; Fiscal Year: 2013
    ..donor organs are subjected to many potential sources of sterile tissue injury, including: donor brain death, prolonged ischemia time, reperfusion injury, surgical trauma, and immunological injury...
  7. CTRIP Ex-vivo perfusion and ventilation of lungs to assess transplant suitability
    Thomas M Egan; Fiscal Year: 2010
    ..organ donors - individuals who sustain a lethal brain injury, but who are intubated and ventilated before brain death occurs...
  8. AMELIORATION OF THE DELETERIOUS EFFECTS OF DONOR BRAIN DEATH
    LUCIA MADARIAGA; Fiscal Year: 2013
    ..We hypothesize that the inflammatory state associated with donor brain death prevents the induction of tolerance in this preclinical model...
  9. Ex vivo perfusion in a lung box for rehabilitation of donor lungs
    Victor E Laubach; Fiscal Year: 2013
    ..Donor lungs are typically retrieved from individuals after brain death;however, there is renewed interest in utilizing non-heart- beating donor (NHBD) lungs retrieved after cardiac ..
  10. Donation After Cardiac Death for Isolated Pancreatic Is*
    Luis Fernandez; Fiscal Year: 2006
    ..a comprehensive assessment of human islets from DCD donors and compare them to islets from Donation after Brain Death (DBD) donors...
  11. VENTRICULAR DYSFUNCTION AFTER SUBARACHNOID HEMORRHAGE
    Jonathan Zaroff; Fiscal Year: 2004
    ..3. Cause of donor brain death (SAH vs...
  12. COGNITIVE RETRAINING IN SUDDEN CARDIAC ARREST SURVIVORS
    MARY SAUVE; Fiscal Year: 2000
    ..A wide range of neurological sequelae ranging from mild intellectual impairment to brain death have been reported...
  13. RENAL EFFECTS OF BRAIN DEATH AND THE MARGINAL DONOR
    Nicholas Tilney; Fiscal Year: 1999
    ..In the initial series of experiments, the effects of brain death, altered systemic hemodynamics and their correction by pressor on the expression of cell adhesion molecules and ..
  14. Physician Peer Minority Organ Donation Education Model
    Akinlolu Ojo; Fiscal Year: 2006
    ..physician leaders as instructors/role models for physicians in selected specialties who regularly encounter brain death and thus, potential cadaveric organ donors (Emergency Medicine, Neurosurgery and Trauma); (2) to deliver a 2-..
  15. ORGAN PRESERVATION FOR TRANSPLANTATION
    JAMES SOUTHARD; Fiscal Year: 2003
    ..Specific Aim 1 will determine the relationship between brain death (BD) and transplant viability, including variables such as time of BD, preservation method, and length of ..
  16. DYNAMIC IMMUNE ASSESSMENT IN TRANSPLANT PATIENTS
    Charles Orosz; Fiscal Year: 2003
    ..be measured as a functional index that summates the impact of all peritransplant insults to the graft (donor brain death and medication', ischemia/reperfusion injury, etc.)...
  17. Strategy for islet recovery, functionality & engraftment
    Juan Contreras; Fiscal Year: 2006
    ..The proposed studies are expected to yield novel information about the effects of BD on isolated islet biology and to develop potential targets for therapeutic intervention, thereby enhancing the efficacy of PIT as a cure for diabetes. ..
  18. Effects of brain-death on islet recovery and functional*
    John Thompson; Fiscal Year: 2006
    ..Overall, these studies will bring novel information about human islet biology and will provide c potential therapeutic strategy to enhance the therapeutic efficacy of PIT as a cure for diabetes. ..
  19. Hormonal Therapy to Increase Islet Recovery/Engraftment From Multiorgan Donors
    Juan Contreras; Fiscal Year: 2008
    ..Studies demonstrated organ deterioration following brain death (BD) by multiple interrelated events, including the effects of cerebral injury, homodynamic instability that ..
  20. A new approach to xenotransplantation in primate
    Juan Contreras; Fiscal Year: 2005
    ..The research proposed in this grant will provide significant information to the xenotransplant research and the potential use of porcine islets as an alternative to human tissue for pancreatic islet transplantation. ..
  21. Toward Optimal End-of-Life Care in the PICU
    Robert Truog; Fiscal Year: 2010
    ....
  22. Molecular Surgeon Symposium on Pancreatic Cancer
    F Brunicardi; Fiscal Year: 2003
    ..All talks will be video-taped and presented at our "The Molecular Surgeon" website for general public access. This website has been established since first symposium in 1999. ..
  23. Biological Markers of Recovery for the Kidney
    John A Kellum; Fiscal Year: 2010
    ..For analyses requiring serial samples and urine samples, we propose to study a subset of trial patients enrolled at 5 sites who consent to additional sample collection (208 patients) ..
  24. FAMILY CONFLICT AND DECISION MAKING FOR ADVANCED CANCER
    Laura Siminoff; Fiscal Year: 2004
    ..Cut-off scores will be provided for classifying concordant and discordant families. In addition, rich and detailed descriptive information about the family treatment decision-making process will be provided. ..
  25. Post Traumatic Nonconvulsive Epileptiform Activity
    Paul Vespa; Fiscal Year: 2005
    ..The hypothesis and unique approach come at a crucial time of failed clinical trials and address an important new therapeutic target. ..
  26. EXCITOTOXICITY IN CIRCULATORY ARREST--BRAIN INJURY
    William Baumgartner; Fiscal Year: 2007
    ....
  27. CORTICAL MECHANISMS IN PERCEPTION AND BEHAVIOR
    Charles Gross; Fiscal Year: 2003
    ..The proposed research may also contribute to the development of visual and limb prostheses and artificial devices for object manipulation. ..
  28. Molecular Dissection of Melatonin Synthesis In Vivo
    Jimo Borjigin; Fiscal Year: 2003
    ....
  29. ISCHEMIC INJURY IN CADAVER DONORS FOR LUNG TRANSPLANT
    Thomas Egan; Fiscal Year: 2003
    ..This will facilitate the introduction of lung retrieval for transplant from NHBDs, which has the potential to extend the lives of thousands of Americans suffering with a variety of lung diseases. ..
  30. THERAPEUTIC RESEARCH CONSENT--EMPIRICAL/ETHICAL ANALYSIS
    Laura Siminoff; Fiscal Year: 2001
    ....
  31. Appraisal Delay and Disparities in Timely Cancer Diagnosis
    Laura A Siminoff; Fiscal Year: 2010
    ....
  32. MRS Detects Metabolic Dysfunction after Brain Injury
    Paul Vespa; Fiscal Year: 2009
    ..The knowledge from the proposed studies will have widespread application to critical care of neurotrauma patients. ..
  33. Ventilator-induced diaphragm dysfunction
    SANFORD NO MIDDLE NAME LEVINE; Fiscal Year: 2010
    ..Moreover, these studies may directly lead to therapy for this newly recognized but relatively common disease of diaphragm muscle. ..
  34. Understanding Consent to Tissue Donation
    Laura Siminoff; Fiscal Year: 2005
    ..This study will be the first to comprehensively examine consent to tissue donation. ..
  35. Patient-Centered Approach to Advance Care Planning
    KARIN KIRCHHOFF; Fiscal Year: 2006
    ..abstract_text> ..
  36. Cerebral Edema in Pediatric Diabetic Ketoacidosis
    MONICA VAVILALA; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  37. Hemodynamics and Outcome in Pediatric Brain Injury
    MONICA VAVILALA; Fiscal Year: 2007
    ..The proposed research will be carried out at the University of Washington, well-known known for mentored patient-oriented research. ..
  38. TLR4 Signaling in Myocardial Ischemia-Reperfusion Injury
    Edward Verrier; Fiscal Year: 2008
    ..Our intention is to focus on the role TLR4 and its signaling pathways in I/R injury to more precisely define therapeutic targets that are specific to myocardial I/R injury. ..
  39. Thromboregulation to Prevent Thrombotic Microangiopathy
    David Cooper; Fiscal Year: 2008
    ..It is anticipated that these approaches will abrogate the development of TM and allow long-term survival of pig organs in baboons. ..
  40. Tolerance to Carbohydrate Antigens in Transplantation
    David Cooper; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  41. Enhancing Advance Care Planning in Diverse Elders with Limited Literacy
    REBECCA SUDORE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  42. Systems Engineering of Pheresis Intervention for Sepsis
    John Kellum; Fiscal Year: 2009
    ..We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.). ..
  43. PUBLIC ATTITUDES TOWARDS DEATH AND ORGAN PROCUREMENT
    Laura Siminoff; Fiscal Year: 2001
    ..Since 1968, the concept of brain death and the "dead donor rule" have guided the determination of death for the purposes of organ procurement...
  44. Ethical Issues in Behavioral Health Research
    James DuBois; Fiscal Year: 2004
    ..The Center for Health Care Ethics at Saint Louis University and the Missouri Institute of Mental Health are committed to sustaining the course beyond year 3. ..