brain diseases

Summary

Summary: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.

Top Publications

  1. ncbi Glia: the fulcrum of brain diseases
    C Giaume
    INSERM, U840 and Collège de France, Paris, France
    Cell Death Differ 14:1324-35. 2007
  2. ncbi Neuroprotective role of the innate immune system by microglia
    I Glezer
    Laboratory of Molecular Endocrinology, CHUL Research Center, Laval University, 2705 Laurier Boul, Quebec, Canada G1V 4G2
    Neuroscience 147:867-83. 2007
  3. pmc Spatial normalization of lesioned brains: performance evaluation and impact on fMRI analyses
    Jenny Crinion
    Wellcome Trust Centre for Neuroimaging, UCL, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 37:866-75. 2007
  4. pmc Towards multimodal atlases of the human brain
    Arthur W Toga
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California, USA
    Nat Rev Neurosci 7:952-66. 2006
  5. ncbi Roles of prostaglandin synthesis in excitotoxic brain diseases
    Takako Takemiya
    Department of Neuropharmacology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
    Neurochem Int 51:112-20. 2007
  6. ncbi Structural connectomics in brain diseases
    Alessandra Griffa
    Signal Processing Laboratory LTS5, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Neuroimage 80:515-26. 2013
  7. ncbi Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases
    Reinhard Gabathuler
    Angiochem Inc, Montreal, Quebec, Canada H2X3Y7
    Neurobiol Dis 37:48-57. 2010
  8. ncbi Taking advantage of the systemic immune system to cure brain diseases
    V Wee Yong
    Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary, 3330 Hospital Drive N W, Calgary, Alberta T2N 4N1, Canada
    Neuron 64:55-60. 2009
  9. pmc Neural deficits in children with dyslexia ameliorated by behavioral remediation: evidence from functional MRI
    Elise Temple
    Program in Neuroscience, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:2860-5. 2003
  10. ncbi The neuroendocrine control of the innate immune system in health and brain diseases
    Marc André Bellavance
    Laboratory of Endocrinology and Genomics, CHUQ Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec, Canada
    Immunol Rev 248:36-55. 2012

Research Grants

  1. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    T O SHEA; Fiscal Year: 2005
  2. Gene Therapy for Neurological Diseases
    Pedro Lowenstein; Fiscal Year: 2006
  3. Intraoperative 3T MRI Scanner for Minimally Invasive Therapy
    Ferenc Jolesz; Fiscal Year: 2007
  4. Perfusion fMRI in Cocaine Addiction
    John Detre; Fiscal Year: 2004
  5. NEUROTERATOGENIC MECHANISM OF LCM VIRUS INFECTION
    Daniel Bonthius; Fiscal Year: 2005
  6. Gene Therapy for Glioma
    Pedro Lowenstein; Fiscal Year: 2004
  7. Risk Factors and the Neurobiologic Substrate of Frailty
    Aron Buchman; Fiscal Year: 2009
  8. PHYSIOLOGY & PATHOPHYSIOLOGY OF ACTIVATION FLOW COUPLING
    John Detre; Fiscal Year: 2002
  9. Drug Abuse, Social Decision-Making, and Sex-Related Functional Brain Asymmetry
    DANIEL T TRANEL; Fiscal Year: 2010
  10. IMAGE GUIDED THERAPY CENTER
    Ferenc Jolesz; Fiscal Year: 2009

Detail Information

Publications290 found, 100 shown here

  1. ncbi Glia: the fulcrum of brain diseases
    C Giaume
    INSERM, U840 and Collège de France, Paris, France
    Cell Death Differ 14:1324-35. 2007
    ....
  2. ncbi Neuroprotective role of the innate immune system by microglia
    I Glezer
    Laboratory of Molecular Endocrinology, CHUL Research Center, Laval University, 2705 Laurier Boul, Quebec, Canada G1V 4G2
    Neuroscience 147:867-83. 2007
    ..of myelin repair, removal of toxic proteins from the CNS and the prevention of neurodegeneration in chronic brain diseases. The ability of glucocorticoids to provide a negative feedback on nuclear factor kappa B pathways in microglia ..
  3. pmc Spatial normalization of lesioned brains: performance evaluation and impact on fMRI analyses
    Jenny Crinion
    Wellcome Trust Centre for Neuroimaging, UCL, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 37:866-75. 2007
    ..This has important implications for users of both structural and functional imaging techniques in the study of patients with structural brain damage...
  4. pmc Towards multimodal atlases of the human brain
    Arthur W Toga
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California, USA
    Nat Rev Neurosci 7:952-66. 2006
    ..These integrative approaches have provided significant impetus for the human brain mapping initiatives, and have important applications in health and disease...
  5. ncbi Roles of prostaglandin synthesis in excitotoxic brain diseases
    Takako Takemiya
    Department of Neuropharmacology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
    Neurochem Int 51:112-20. 2007
    ..This review also discusses a novel role of vascular endothelial cells in brain diseases. We found that these cells produce PGE(2) by synthesizing COX-2 and microsomal prostaglandin E synthase-1 (..
  6. ncbi Structural connectomics in brain diseases
    Alessandra Griffa
    Signal Processing Laboratory LTS5, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Neuroimage 80:515-26. 2013
    ....
  7. ncbi Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases
    Reinhard Gabathuler
    Angiochem Inc, Montreal, Quebec, Canada H2X3Y7
    Neurobiol Dis 37:48-57. 2010
    ....
  8. ncbi Taking advantage of the systemic immune system to cure brain diseases
    V Wee Yong
    Hotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary, 3330 Hospital Drive N W, Calgary, Alberta T2N 4N1, Canada
    Neuron 64:55-60. 2009
    ....
  9. pmc Neural deficits in children with dyslexia ameliorated by behavioral remediation: evidence from functional MRI
    Elise Temple
    Program in Neuroscience, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:2860-5. 2003
    ....
  10. ncbi The neuroendocrine control of the innate immune system in health and brain diseases
    Marc André Bellavance
    Laboratory of Endocrinology and Genomics, CHUQ Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec, Canada
    Immunol Rev 248:36-55. 2012
    ..Here we review these mechanisms and discuss data supporting both neuroprotective and detrimental roles of the neuroendocrine control of innate immunity...
  11. ncbi Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases
    Wolfgang Loscher
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Bunteweg 17, D 30559 Hannover, Germany
    Prog Neurobiol 76:22-76. 2005
    ..the current knowledge about drug efflux transporters as a major determinant of multidrug resistance of brain diseases such as epilepsy is reviewed...
  12. ncbi Blood-brain barrier dysfunction in brain diseases: clinical experience
    Karl Schoknecht
    Institute of Neurophysiology, Charite University Medicine Berlin, Berlin, Germany
    Epilepsia 53:7-13. 2012
    ..Elucidating the specific pathways of blood-brain barrier dysfunction at different time points and in different brain diseases using novel imaging techniques promises a more accurate blood-brain barrier terminology as well as new ..
  13. ncbi Supramolecular devices to improve the treatment of brain diseases
    Donatella Paolino
    Department of Experimental and Clinical Medicine, Faculty of Medicine, University Magna Græcia of Catanzaro, Campus Universitario S Venuta, Building of Biosciences, Viale S Venuta, I 88100 Germaneto CZ, Italy
    Drug Discov Today 16:311-24. 2011
    ..Polymolecular (liposomes, niosomes, nanogels) and oligomolecular (cyclodextrins) devices have potential clinical applications in brain drug delivery, being capable of active targeting that can concentrate bioactives in the brain...
  14. ncbi Neuropathologic measurements in focal cortical dysplasias: validation of the ILAE 2011 classification system and diagnostic implications for MRI
    Angelika Mühlebner
    Department of Neuropathology, University Hospital Erlangen, Germany
    Acta Neuropathol 123:259-72. 2012
    ..The systematic analysis of well-specified histopathological features could be helpful to improve sensitivity and specificity in MRI detection during pre-surgical work-up of patients with drug-resistant focal epilepsies...
  15. ncbi MicroRNAs in neural cell development and brain diseases
    Wei Feng
    Department of Pharmacology, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Sci China Life Sci 54:1103-12. 2011
    ....
  16. ncbi Elevated serum levels of S-100beta protein and neuron-specific enolase are associated with brain injury in patients with severe sepsis and septic shock
    Duc Nam Nguyen
    Critical Care Department, Vrije Universiteit Brussel, Brussels, Belgium
    Crit Care Med 34:1967-74. 2006
    ..We investigated whether serum levels of neuron-specific enolase (NSE) and S-100beta protein could be used to evaluate cerebral injury and to predict outcome in severe sepsis and severe septic shock...
  17. ncbi Adenosine receptors and brain diseases: neuroprotection and neurodegeneration
    Catarina V Gomes
    Center for Neurosciences of Coimbra, University of Coimbra, Coimbra, Portugal
    Biochim Biophys Acta 1808:1380-99. 2011
    ..In spite of this current mechanistic uncertainty, it seems evident that targeting adenosine receptors might indeed constitute a novel strategy to control the demise of different neurological and psychiatric disorders...
  18. ncbi Essential fatty acids and the brain: possible health implications
    K A Youdim
    Laboratory of Neuroscience, United States Department of Agriculture, Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Int J Dev Neurosci 18:383-99. 2000
    ..Thus it may be that an optimal diet with a balance of n-6 and n-3 fatty acids may help to delay their onset or reduce the insult to brain functions which these diseases elicit...
  19. ncbi Migraine is associated with magnetic resonance imaging white matter abnormalities: a meta-analysis
    Richard H Swartz
    Division of Neurology, Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario M5G 1X5, Canada
    Arch Neurol 61:1366-8. 2004
    ..These abnormalities may be important as a risk factor for future stroke. Further, it is controversial whether any increased risk of WMAs is attributable to comorbidities such as vascular disease...
  20. ncbi Typical cerebral metabolic patterns in neurodegenerative brain diseases
    Laura K Teune
    Department of Neurology, University Medical Center Groningen, Groningen, The Netherlands
    Mov Disord 25:2395-404. 2010
    The differential diagnosis of neurodegenerative brain diseases on clinical grounds is difficult, especially at an early disease stage...
  21. ncbi Neurocircuitry in alcoholism: a substrate of disruption and repair
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences and Neuroscience Program, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Psychopharmacology (Berl) 180:583-94. 2005
    ....
  22. ncbi Inflammatory cytokines at the summits of pathological signal cascades in brain diseases
    Lawrence Steinman
    Departments of Pediatrics and Neurology and Neurological Sciences, Stanford University, Beckman Center for Molecular Medicine, Stanford, CA 94305 5316, USA
    Sci Signal 6:pe3. 2013
    ..Targeting these cytokines or their receptors can alter the course of several neurological diseases, but the effects may be beneficial or harmful...
  23. ncbi A prospective study of fetuses with isolated ventriculomegaly investigated by antenatal sonography and in utero MR imaging
    P D Griffiths
    Academic Unit of Radiology, University of Sheffield, Sheffield, UK
    AJNR Am J Neuroradiol 31:106-11. 2010
    ....
  24. pmc COL4A2 mutation associated with familial porencephaly and small-vessel disease
    Elly Verbeek
    Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Eur J Hum Genet 20:844-51. 2012
    ....
  25. ncbi Adenosine and related drugs in brain diseases: present and future in clinical trials
    Luisa V Lopes
    Institute of Pharmacology and Neurosciences, Instituto de Medicina Molecular, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Curr Top Med Chem 11:1087-101. 2011
    ..The evidence herein reviewed highlights the promising potential of adenosine or adenosine receptor ligands as therapeutic agents in several brain disorders...
  26. ncbi Spatial normalization of brain images with focal lesions using cost function masking
    M Brett
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, CB2 2EF, UK
    Neuroimage 14:486-500. 2001
    ....
  27. ncbi Limb remote postconditioning alleviates cerebral reperfusion injury through reactive oxygen species-mediated inhibition of delta protein kinase C in rats
    Qiang Wang
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an 710032 Shaanxi Province, China
    Anesth Analg 113:1180-7. 2011
    ....
  28. ncbi Diffusion-weighted imaging for the differential diagnosis of disorders affecting the hippocampus
    A Forster
    Department of Neurology, Universitatsmedizin Mannheim, University of Heidelberg, Mannheim, Germany
    Cerebrovasc Dis 33:104-15. 2012
    ..This review presents recent studies using the diffusion-weighted imaging (DWI) technique in diseases involving the hippocampus...
  29. ncbi Hashimoto's encephalopathy: systematic review of the literature and an additional case
    Narriane Chaves P de Holanda
    Agamenon Magalha es Hospital, Recife PE, Brazil
    J Neuropsychiatry Clin Neurosci 23:384-90. 2011
    ..Because the symptoms respond so well to immunosuppressive treatment, prompt diagnosis and management are important. Here, the authors present a representative case report, along with a comprehensive review of current literature...
  30. ncbi Cerebral restorative plasticity from normal ageing to brain diseases: a "never ending story"
    Doriana Landi
    Clinical Neurology, Campus Bio Medico University, Rome, Italy
    Restor Neurol Neurosci 28:349-66. 2010
    ..A clarification of advantageous as well as of aberrant brain plasticity mechanisms in pathological conditions may help to improve the development of rehabilitation methods to better address and facilitate such processes...
  31. pmc Rett syndrome and other autism spectrum disorders--brain diseases of immune malfunction?
    N C Derecki
    Neuroscience Graduate Program, University of Virginia, Charlottesville, VA 229081, USA
    Mol Psychiatry 15:355-63. 2010
    ....
  32. ncbi Diffusion tensor MR imaging and fiber tractography: theoretic underpinnings
    P Mukherjee
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94143 0628, USA
    AJNR Am J Neuroradiol 29:632-41. 2008
    ..The emphasis is on optimizing these factors for state-of-the-art DWI and DTI based on the best available evidence in the literature...
  33. ncbi Concise review: Patient-derived olfactory stem cells: new models for brain diseases
    Alan Mackay-Sim
    National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia
    Stem Cells 30:2361-5. 2012
    Traditional models of brain diseases have had limited success in driving candidate drugs into successful clinical translation. This has resulted in large international pharmaceutical companies moving out of neuroscience research...
  34. ncbi Effects of cytomegalovirus infection on embryogenesis and brain development
    Yoshihiro Tsutsui
    Faculty of Health Sciences, Hamamatsu University, Hamamatsu, Japan
    Congenit Anom (Kyoto) 49:47-55. 2009
    ..These cellular events may cause brain malformations, such as microcephaly and polymicrogyria. Furthermore, MCMV persists in neuronal cells in developing brains, presumably resulting in neuronal dysfunction...
  35. ncbi Drug resistance in brain diseases and the role of drug efflux transporters
    Wolfgang Loscher
    Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, and Center for Systems Neuroscience, Bunteweg 17, D 30559 Hannover, Germany
    Nat Rev Neurosci 6:591-602. 2005
    ..There is increasing evidence that drug efflux transporters have an important role in drug-resistant brain disorders, and this information should allow more efficacious treatment strategies to be developed...
  36. pmc Sepsis-associated encephalopathy: a magnetic resonance imaging and spectroscopy study
    Fernando A Bozza
    ICU, Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
    J Cereb Blood Flow Metab 30:440-8. 2010
    ..These findings highlight the potential applications of MRI techniques for the diagnostic and therapeutic studies in sepsis...
  37. ncbi A reassessment of vascular endothelial growth factor in central nervous system pathology
    Marsha J Merrill
    Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1414, USA
    J Neurosurg 103:853-68. 2005
    ..In many cases, therapeutic interventions targeting the VEGF/VEGF receptor axis are likely to be ineffective or even detrimental. Clinical manipulation of VEGF levels in the CNS must be approached with caution...
  38. ncbi Sepsis associated encephalopathy
    G Consales
    Division of Anesthesiology and Critical Care, Hospital Careggi, University of Florence, Florence, Italy
    Minerva Anestesiol 71:39-52. 2005
    ..At this moment a specific treatment for SAE does not exist and outcome relies upon prompt and appropriate treatment of sepsis as a whole...
  39. pmc Impaired cerebrovascular reactivity in sepsis-associated encephalopathy studied by acetazolamide test
    Szilárd Szatmári
    Department of Anesthesiology and Intensive Care, University of Debrecen, Health and Medical Science Center, Debrecen, Nagyerdei krt, Hungary
    Crit Care 14:R50. 2010
    ..The aim of the present work was to test whether cerebral vasomotor-reactivity is impaired in patients with SAE...
  40. ncbi Influenza surveillance system of Japan and acute encephalitis and encephalopathy in the influenza season
    N Okabe
    Infectious Disease Surveillance Center, National Institute of Infectious Disease, Tokyo, Japan
    Pediatr Int 42:187-91. 2000
    ..To understand the situation of influenza epidemics and neurologic complications during the influenza season in Japan...
  41. ncbi Sepsis associated encephalopathy studied by MRI and cerebral spinal fluid S100B measurement
    Ornella Piazza
    Dipartimento di Scienze Chirurgiche Anestesiologiche Rianimatorie e dell Emergenza, Universita degli Studi di Napoli Federico II, Via Pansini 5, 80131, Naples, Italy
    Neurochem Res 34:1289-92. 2009
    ..BBB damage may be numbered among the contributors of SAE, which aetiology is certainly multifactorial: an interplay between the toxic mediators involved in sepsis and the indirect effects of hyperthermia, hypossia and hypoperfusion...
  42. ncbi Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996
    E M Wassermann
    Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1428, USA
    Electroencephalogr Clin Neurophysiol 108:1-16. 1998
    ....
  43. ncbi Novel COL4A1 mutations associated with HANAC syndrome: a role for the triple helical CB3[IV] domain
    Emmanuelle Plaisier
    AP HP, Department of Nephrology, Tenon Hospital, INSERM U702, UMRS702, Universite Pierre et Marie Curie Paris 6, Paris, France
    Am J Med Genet A 152:2550-5. 2010
    ....
  44. ncbi An automated procedure for the assessment of white matter hyperintensities by multispectral (T1, T2, PD) MRI and an evaluation of its between-centre reproducibility based on two large community databases
    Pauline Maillard
    Centre d Imagerie Neurosciences et Applications aux Pathologies, CI NAPS, CNRS, CEA, Université de Caen Université Paris Descartes, GIP Cyceron, Boulevard Becquerel, BP 5229, 14074, Caen, France
    Neuroradiology 50:31-42. 2008
    ....
  45. ncbi Targeting regulation of ABC efflux transporters in brain diseases: a novel therapeutic approach
    Heidrun Potschka
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University, Koeniginstr 16, D 80539 Munich, Germany
    Pharmacol Ther 125:118-27. 2010
    ....
  46. ncbi Hashimoto's encephalopathy : epidemiology, pathogenesis and management
    Ramon Mocellin
    Neuropsychiatry Unit, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    CNS Drugs 21:799-811. 2007
    ..Some authors have suggested abandoning any link to Hashimoto and renaming the condition 'steroid responsive encephalopathy associated with autoimmune thyroiditis' to better reflect current, if limited, understanding of this condition...
  47. ncbi Hashimoto's encephalopathy
    Nicoline Schiess
    Department of Neurology, Division of Neuroimmunology and Neuroinfectious Disorders, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Ann N Y Acad Sci 1142:254-65. 2008
    ..Further controlled studies of the use of steroids, plasmapheresis, or immunosuppressant medications are needed in the future to prove the concept of the pathogenic role of antithyroid antibodies in HE...
  48. ncbi Acute childhood encephalitis and encephalopathy associated with influenza: a prospective 11-year review
    Reshma Amin
    Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Pediatr Infect Dis J 27:390-5. 2008
    ..Influenza virus infection has been associated with a variety of neurologic complications. The objective of this study was to evaluate prospectively the role of influenza viruses in acute childhood encephalitis/encephalopathy (ACE)...
  49. ncbi Impact of emergency room neurologists on patient management and outcome
    Thierry Moulin
    Department of Neurology, University Hospital, Besancon, France
    Eur Neurol 50:207-14. 2003
    ..The frequency and impact of in-patient assessment by a neurologist in the emergency room (ER) setting remain largely underestimated. The objective of our study was to analyse the impact of neurologist in-patient management...
  50. ncbi Mitochondrial nitric oxide synthase, mitochondrial brain dysfunction in aging, and mitochondria-targeted antioxidants
    Ana Navarro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, 11003 Cadiz, Spain
    Adv Drug Deliv Rev 60:1534-44. 2008
    ..Mitochondria-targeted antioxidants, phosphonium cation derivatives and antioxidant tetrapeptides, are reviewed in terms of structures and biological effects...
  51. ncbi Acute encephalopathy associated with influenza A virus infection
    Christoph Steininger
    Institute of Virology, University of Vienna, Austria
    Clin Infect Dis 36:567-74. 2003
    ..Thus, influenzal encephalopathy is frequently associated with metabolic disorders, whereas postinfluenzal encephalopathy appears to have different possible etiologies...
  52. ncbi Cerebral white matter lesions are associated with the risk of stroke but not with other vascular events: the 3-City Dijon Study
    Jean François Buyck
    INSERM Unit 708, Paris, France
    Stroke 40:2327-31. 2009
    ..We evaluated the risk of stroke and other vascular events according to WML volume in a large population-based sample. We also studied WML volume by type (deep or periventricular) in relation to these events...
  53. pmc Nicotinamide phosphoribosyltransferase may be involved in age-related brain diseases
    Li Ying Liu
    Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
    PLoS ONE 7:e44933. 2012
    ..together, we have revealed a region- and cell-specific change of NAMPT level in brain and serum upon aging, deduced its potential consequences, which suggests that NAMPT is a regulatory factor in aging and age-related brain diseases.
  54. ncbi Novel mutation in MCT8 gene in a Brazilian boy with thyroid hormone resistance and severe neurologic abnormalities
    Hamilton Cabral de Menezes Filho
    Pediatric Endocrinology Unit, Instituto da Criança, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Arq Bras Endocrinol Metabol 55:60-6. 2011
    ....
  55. ncbi A unifying hypothesis of schizophrenia: abnormal immune system development may help explain roles of prenatal hazards, post-pubertal onset, stress, genes, climate, infections, and brain dysfunction
    DENNIS K KINNEY
    Genetics Laboratory, Mailman Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States
    Med Hypotheses 74:555-63. 2010
    ..This possibility could be tested experimentally--e.g., by clinical trials in which patients' exposure to infection is reduced or immune function is normalized...
  56. ncbi Cerebral involvement in respiratory syncytial virus disease
    Michael Eisenhut
    Brain Dev 29:454. 2007
  57. ncbi NAD+ and NADH in brain functions, brain diseases and brain aging
    Weihai Ying
    Department of Neurology, University of California at San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Front Biosci 12:1863-88. 2007
    ..it is proposed that NAD+ and NADH are fundamental mediators of brain functions, brain senescence and multiple brain diseases. Because numerous properties of NAD+ and NADH remain unclear, future studies regarding NAD+ and NADH may ..
  58. ncbi Blood-brain barrier transport of drugs for the treatment of brain diseases
    Reinhard Gabathuler
    Angiochem Inc, Montreal, Quebec, Canada
    CNS Neurol Disord Drug Targets 8:195-204. 2009
    ..As a result, various strategies are being developed to enhance access of drugs to the brain parenchyma at therapeutically meaningful concentrations to effectively manage disease...
  59. ncbi Elevated CSF IL-6 in a patient with respiratory syncytial virus encephalopathy
    Yuko Otake
    Department of Pediatrics, Jichi Medical University, 3311 1 Yaksiji, Shimotsuke, Tochigi, Japan
    Brain Dev 29:117-20. 2007
    ....
  60. ncbi Vanishing white matter disease
    Marjo S van der Knaap
    Department of Pediatrics and Child Neurology, VU University Medical Center, Amsterdam, Netherlands
    Lancet Neurol 5:413-23. 2006
    ..Recently, undue activation of the unfolded-protein response has emerged as important in the pathophysiology of VWM, but the selective vulnerability of glia for defects in eIF2B is poorly understood...
  61. ncbi Bronchiolitis-associated encephalopathy in critically-ill infants: an underestimated complication?
    Roberto Antonucci
    Department of Pediatrics and Clinical Medicine, University of Cagliari, Cagliari, Italy
    J Matern Fetal Neonatal Med 23:431-6. 2010
    ..To investigate the bronchiolitis-associated encephalopathy in critically ill infants...
  62. pmc Attribute vector guided groupwise registration
    Qian Wang
    Department of Computer Science, University of North Carolina at Chapel Hill, NC 27599, USA
    Neuroimage 50:1485-96. 2010
    ..The experimental results demonstrate that our method yields better registration accuracy, compared with a popular groupwise registration method...
  63. ncbi Nardilysin in human brain diseases: both friend and foe
    H G Bernstein
    Department of Psychiatry, Otto v Guericke University Magdeburg, Germany
    Amino Acids 45:269-78. 2013
    ..Less is known about possible implications of nardilysin for brain diseases. This review, which includes some of our own recent findings, attempts to summarize the current knowledge on ..
  64. pmc Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations
    Kaya Bilguvar
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 467:207-10. 2010
    ..These findings unify previously disparate aspects of cerebral cortical development and highlight the use of whole-exome sequencing to identify disease loci in settings in which traditional methods have proved challenging...
  65. ncbi Alterations in the brain electrical activity in a rat model of sepsis-associated encephalopathy
    Ilker M Kafa
    Department of Anatomy, Uludag University, School of Medicine, Bursa, Turkey
    Brain Res 1354:217-26. 2010
    ....
  66. ncbi EEG patterns and imaging correlations in encephalopathy: encephalopathy part II
    Peter W Kaplan
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Clin Neurophysiol 28:233-51. 2011
    ..This overview highlighting EEG-imaging correlations may help the treating physician in the diagnosis, and hence the appropriate treatment, of patients with encephalopathy...
  67. ncbi Mitochondria-targeted antioxidants as promising drugs for treatment of age-related brain diseases
    Vladimir P Skulachev
    Faculty of Bioengineering and Bioinformatics and A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, Russia
    J Alzheimers Dis 28:283-9. 2012
    ..In this article, I will summarize the present state of the art in this field. I conclude that mitochondria-targeted rechargeable antioxidants are promising as tools to treat brain pathologies developing in elderly humans...
  68. ncbi Mortality of sea lions along the central California coast linked to a toxic diatom bloom
    C A Scholin
    Monterey Bay Aquarium Research Institute, California 95039, USA
    Nature 403:80-4. 2000
    ..Such findings reveal that monitoring of mussel toxicity alone does not necessarily provide adequate warning of DA entering the food web at levels sufficient to harm marine wildlife and perhaps humans...
  69. ncbi Histamine in neurotransmission and brain diseases
    Saara Nuutinen
    Institute of Biomedicine, University of Helsinki, Helsinki, Finland
    Adv Exp Med Biol 709:95-107. 2010
    ..Ongoing clinical trials will reveal the efficacy and safety of these drugs in the treatment of human patients...
  70. ncbi The impact of magnetic resonance imaging-detected white matter hyperintensities on longitudinal changes in regional cerebral blood flow
    Michael A Kraut
    Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Cereb Blood Flow Metab 28:190-7. 2008
    ..The longitudinal increases may reflect cortical compensation mechanisms for reduced efficacy of interregional neural communications that result from white matter deterioration...
  71. ncbi Hashimoto's encephalopathy: neuropsychological findings
    I Mazzù
    Santa Lucia Foundation, Rome, Italy
    Neurol Sci 33:653-6. 2012
    ..This pattern of cognitive impairment suggests that, after an initial phase characterized by diffuse brain involvement, our patient was primarily affected by frontal lobe sufferance...
  72. ncbi Fatal rhino-orbito-cerebral infection caused by Saksenaea vasiformis in an immunocompetent individual: first case report from India
    V P Baradkar
    Department of Microbiology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra, India
    Indian J Med Microbiol 26:385-7. 2008
    ..We believe this case to be the first case of rhino-orbito-cerebral infection due to Saksenaea vasiformis and that of second case in an immunocompetent patient in the world...
  73. pmc Modulators of nucleoside metabolism in the therapy of brain diseases
    Detlev Boison
    RS Dow Neurobiology Laboratories, Legacy Research, 1225 NE 2nd Ave, Portland, OR 97232, USA
    Curr Top Med Chem 11:1068-86. 2011
    Nucleoside receptors are known to be important targets for a variety of brain diseases. However, the therapeutic modulation of their endogenous agonists by inhibitors of nucleoside metabolism represents an alternative therapeutic strategy ..
  74. ncbi Neuroimaging and pathological findings in a child with cerebral sparganosis. Case report
    Gao Bo
    Department of Radiology, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou Province, People s Republic of China
    J Neurosurg 105:470-2. 2006
    ..Following surgery, the patient's neurological deficits markedly improved. The authors review the pathological and imaging features of cerebral sparganosis...
  75. ncbi Hashimoto encephalopathy: clinical and MRI improvement following high-dose corticosteroid therapy
    Thashi Chang
    Institute of Neurology, National Hospital of Sri Lanka, Colombo, Sri Lanka
    Neurologist 16:394-6. 2010
    ..Diffuse or focal white matter changes suggesting primary demyelination on magnetic resonance imaging (MRI) has been reported in only a few patients with HE. Follow-up imaging studies have been sparse...
  76. ncbi Multiple intracranial hydatid cysts in a boy
    Halit Cavusoglu
    Sisli Etfal Training and Research Hospital, Neurosurgery Clinic, Istanbul, Turkey
    Turk Neurosurg 19:203-7. 2009
    ..Hydatid cyst is a benign lesion. Surgery is the standard and most effective treatment for intracranial hydatid cysts. Appropriate and timely management is mandatory for reducing the mortality and morbidity...
  77. ncbi Encephalopathy in children: an approach to assessment and management
    Emily Davies
    Department of Paediatric Neurology, Sheffield Children s Hospital, NHS Foundation Trust, Sheffield, UK
    Arch Dis Child 97:452-8. 2012
    ....
  78. ncbi [Hashimoto's encephalopathy with bilateral pallidal lesions presenting memory disturbance and executive dysfunction]
    Mami Fukunaga
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Rinsho Shinkeigaku 46:568-71. 2006
    ....
  79. ncbi Fyn kinase in brain diseases and cancer: the search for inhibitors
    S Schenone
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Genova, Viale Benedetto XV, 3, I 16132, Genova, Italy
    Curr Med Chem 18:2921-42. 2011
    ....
  80. ncbi Diagnosis and stereotactic aspiration treatment of cerebral sparganosis: summary of 11 cases
    Lei Deng
    Department of Neurosurgery, No 94 Hospital of People s Liberation Army, Nanchang, Jiangxi Province, People s Republic of China
    J Neurosurg 114:1421-5. 2011
    ....
  81. ncbi The rises and falls of disconnection syndromes
    Marco Catani
    Centre for Neuroimaging Sciences, Institute of Psychiatry, De Crespigny Park, London, UK
    Brain 128:2224-39. 2005
    ....
  82. ncbi The role of head computer tomographic scans on the management of MICU patients with neurological dysfunction
    Daniel Salerno
    Division of Pulmonary and Critical Care Medicine, Christiana Health Care System, Newark, Delaware 19805, USA
    J Intensive Care Med 24:372-5. 2009
    ..This study suggests that clinicians should have a low threshold for ordering a CT scan in MICU patients with acute neurological dysfunction...
  83. ncbi The differences in epileptic characteristics in patients with porencephaly and schizencephaly
    Miki Shimizu
    Department of Pediatrics and Child Neurology, Oita University Faculty of Medicine, Yufu, Oita, Japan
    Brain Dev 34:546-52. 2012
    ..A trial of rational monotherapy or two-drug therapy may be effective, rather than larger-number polytherapy in many cases, more in porencephaly than schizencephaly...
  84. ncbi Sensitive time-windows for susceptibility in neurodevelopmental disorders
    Rhiannon M Meredith
    Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research CNCR, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Trends Neurosci 35:335-44. 2012
    ..Existence of sensitive time-windows has significant implications for our understanding of early brain development underlying NDDs and may indicate vulnerable periods when the brain is more susceptible to current therapeutic treatments...
  85. pmc MR spectroscopy and MR perfusion character of cerebral sparganosis: a case report
    C H Chiu
    Department of Medical Imaging, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    Br J Radiol 83:e31-4. 2010
    ..During surgery for the removal of a granuloma, the parasite was discovered and excised. Following treatment, the patient's neurological deficits markedly improved...
  86. ncbi Autoimmune encephalopathies and epilepsies in children and teenagers
    Lily C Wong-Kisiel
    Division of Child and Adolescent Neurology, Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Can J Neurol Sci 39:134-44. 2012
    ..This review summarizes the clinical presentations and recommended evaluations and treatment of pediatric epileptic encephalopathy suspected to be of autoimmune etiology...
  87. ncbi Chromogranin peptides in brain diseases
    Michael Willis
    Department of General Psychiatry, Medical University Innsbruck, Innsbruck, Austria
    J Neural Transm 118:727-35. 2011
    ..Further understanding of role and function of chromogranin peptides in neuropathological conditions is still required...
  88. ncbi A methodology for assessing treatment response in Hashimoto's encephalopathy: a case study demonstrating repeated computerized neuropsychological testing
    Brian L Brooks
    Neurosciences Program, Alberta Children s Hospital, Calgary, AB, Canada
    J Child Neurol 26:786-91. 2011
    ..Computerized neuropsychological testing seems to be a viable tool for tracking cognitive functioning (when rapid assessments are desired) and assessing response to corticosteroid treatment in Hashimoto's encephalopathy...
  89. ncbi Neurobehavioral tests in rat models of degenerative brain diseases
    Yvonne K Urbach
    Franz Penzoldt Center, Experimental Therapy, Friedrich Alexander University of Erlangen Nurnberg, Erlangen, Germany
    Methods Mol Biol 597:333-56. 2010
    ....
  90. ncbi Sepsis-associated encephalopathy and its differential diagnosis
    Emanuele Iacobone
    General Intensive Care Unit, Fermo Hospital Ancona, Italy
    Crit Care Med 37:S331-6. 2009
    ..Patient management is based mainly on controlling infection, organ system failure, and metabolic homeostasis, at the same time avoiding neurotoxic drugs...
  91. ncbi [Hashimoto encephalopathy. Analysis of four case reports]
    F Archambeaud
    , , 23, avenue D.-Larrey, 87042 Limoges, France
    Rev Med Interne 22:653-9. 2001
    ..Pathogenic mechanisms are not clear but probably involve autoimmune cerebral vasculitis because of the efficacy of steroids...
  92. ncbi EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy
    Jörg Dietrich
    Department of Biomedical Genetics, Aab Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Med 11:277-83. 2005
    ..This raises the possibility that a deficiency in astrocyte function may contribute to the loss of white matter in VWM leukodystrophy...
  93. ncbi Understanding and circumventing the blood-brain barrier
    D J Begley
    Centre for Neuroscience Research, Kings College London, Guy s Campus, London, UK
    Acta Paediatr Suppl 92:83-91. 2003
    ..The challenges posed by the blood-brain barrier and the possibilities for overcoming them are reviewed...
  94. ncbi Hashimoto's encephalopathy: postmortem findings after fatal status epilepticus
    Philip Duffey
    Department of Neurology, York Hospital, UK
    Neurology 61:1124-6. 2003
    ....
  95. ncbi Intracranial involvement in extramedullary hematopoiesis: case report and review of the literature
    Salwa Haidar
    Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Pediatr Radiol 35:630-4. 2005
    ..The diagnosis was confirmed by sulfur colloid isotope scan...
  96. ncbi Selenium and selenoproteins in the brain and brain diseases
    Jun Chen
    Department of Cell and Molecular Biology, University of Hawaii at Manoa, Honolulu 96866, USA
    J Neurochem 86:1-12. 2003
    ..Future research directions will surely unravel the important functions of this class of proteins in the brain...
  97. ncbi A novel type of encephalopathy associated with mushroom Sugihiratake ingestion in patients with chronic kidney diseases
    Fumitake Gejyo
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Kidney Int 68:188-92. 2005
    ..While the exact etiology of this encephalopathy remained mysterious, we aimed to describe its clinical features...
  98. ncbi Image-matching as a medical diagnostic support tool (DST) for brain diseases in children
    H K Huang
    Image Processing and Informatics Lab, Information Science Institute University of Southern California, 4676 Admiralty Way, Suite 601, Marina del Rey, CA 90292, USA
    Comput Med Imaging Graph 29:195-202. 2005
    ..To evaluate the usefulness of the DST in a clinical setting, pediatric brain diseases were used...
  99. ncbi Regional brain volume differences associated with hyperglycemia and severe hypoglycemia in youth with type 1 diabetes
    Dana C Perantie
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes Care 30:2331-7. 2007
    ..This study is the first to quantify regional brain volume differences in a large sample of youth with diabetes...
  100. ncbi Modelling brain diseases in mice: the challenges of design and analysis
    Kei Watase
    Department of Molecular and Human Genetics and Howard Hughes Medical Institute, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA
    Nat Rev Genet 4:296-307. 2003
    ....
  101. ncbi Mapping genetic influences on human brain structure
    Paul Thompson
    Laboratory of Neuro Imaging and Brain Mapping Division, Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Ann Med 34:523-36. 2002
    ..Computational methods from brain imaging and genetics can be fruitfully merged, to shed light on the inheritance of personality differences and behavioral traits, and the genetic transmission of diseases that affect the human brain...

Research Grants83

  1. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    T O SHEA; Fiscal Year: 2005
    ..abstract_text> ..
  2. Gene Therapy for Neurological Diseases
    Pedro Lowenstein; Fiscal Year: 2006
    ..abstract_text> ..
  3. Intraoperative 3T MRI Scanner for Minimally Invasive Therapy
    Ferenc Jolesz; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  4. Perfusion fMRI in Cocaine Addiction
    John Detre; Fiscal Year: 2004
    ..abstract_text> ..
  5. NEUROTERATOGENIC MECHANISM OF LCM VIRUS INFECTION
    Daniel Bonthius; Fiscal Year: 2005
    ..The importance of a-DG in influencing the tropism and infectivity of LCMV will be examined by blocking alpha-DG with an antibody prior to exposure of brain slices to LCMV. ..
  6. Gene Therapy for Glioma
    Pedro Lowenstein; Fiscal Year: 2004
    ..Our long term aim is to translate this novel therapeutic approach into a Phase I clinical trial for GBM. ..
  7. Risk Factors and the Neurobiologic Substrate of Frailty
    Aron Buchman; Fiscal Year: 2009
    ..abstract_text> ..
  8. PHYSIOLOGY & PATHOPHYSIOLOGY OF ACTIVATION FLOW COUPLING
    John Detre; Fiscal Year: 2002
    ..These studies will provide further insight into the parameters affecting the AFC response, and will suggest approaches for optimizing and interpreting functional imaging data. ..
  9. Drug Abuse, Social Decision-Making, and Sex-Related Functional Brain Asymmetry
    DANIEL T TRANEL; Fiscal Year: 2010
    ..abstract_text> ..
  10. IMAGE GUIDED THERAPY CENTER
    Ferenc Jolesz; Fiscal Year: 2009
    ..abstract_text> ..
  11. CYCLOOXYGENASE AND ANTI-INFLAMMATORY DRUGS IN AD
    Giulio Pasinetti; Fiscal Year: 2001
    ..The outcome of the proposed studies will be immediately relevant to the design of human trials. ..
  12. Glial Biology Gordon Research Conference
    Vladimir Parpura; Fiscal Year: 2007
    ..This Glial Biology Conference provides an international forum for emerging, innovative research related to glia functions and cell-cell interactions in health and disease. ..
  13. Perfusion MRI for multisite studies of brain function
    John A Detre; Fiscal Year: 2010
    ..The resulting technology will be made available to the biomedical community as a research product. ..
  14. Structural Brain Imaging in Psychopathy
    Yaling Yang; Fiscal Year: 2007
    ..By uncovering the neural basis of psychopathy, this proposal will hopefully provide valuable scientific knowledge that will facilitate the development of prevention and treatment of this disorder. [unreadable] [unreadable] [unreadable]..
  15. MRI OF STRUCTURE/FUNCTION IN TEMPORAL LOBE EPILEPSY
    John Detre; Fiscal Year: 2003
    ..Validation of an fMRI protocol for assessing memory function will improve the safety and quality of the preoperative assessment for temporal lobectomy, and may have important implications for neurosurgical planning and prognosis. ..
  16. COMPLEMENT AND NEUROPROTECTION: ALZHEIMER'S DISEASE
    Giulio Pasinetti; Fiscal Year: 2002
    ..Further characterization of the complex role of complement proteins in neurodegeneration is essential especially in view of the possibility that the complement system represents a target for therapeutic interventions in AD. ..
  17. Viral vector-based RNAi therapy for Alexander Disease
    Daniel Bonthius; Fiscal Year: 2008
    ..The disease is due to an abnormal gene. This research aims to develop a form of gene therapy to prevent and reverse the brain dysfunction of Alexander Disease. [unreadable] [unreadable] [unreadable]..
  18. Pinitol a Natural Extract from Pine Cones and Alzheimer's Disease
    Giulio Pasinetti; Fiscal Year: 2006
    ..abstract_text> ..
  19. Cell Cycle and COX-2 in a Mouse Model of Alzheimer's
    Giulio Pasinetti; Fiscal Year: 2004
    ....
  20. Calcium-dependent glutamate release from astrocytes
    Vladimir Parpura; Fiscal Year: 2008
    ..Since astrocytes modulate synaptic transmission by releasing glutamate, this new insight into glial action has potential to change the way we think about central nervous system functions and dysfunctions [unreadable] [unreadable]..
  21. Early brain development after prenatal "Ice" exposure: A Longitudinal MR study
    Linda Chang; Fiscal Year: 2009
    ..Detailed maternal drug use, psychosocial and mood evaluations will be performed and correlated with biological brain changes in these children. ..
  22. Evaluation of New Imaging Methodologies at 7T
    EWART HAACKE; Fiscal Year: 2007
    ..Many of the approaches developed and applied on this animal system are expected to have important clinical impact. All of these projects will substantially benefit from the proposed acquisition. [unreadable] [unreadable] [unreadable]..
  23. FETAL NEUROBEHAVIORAL DEVELOPMENT & POSTNATAL CONTINUITY
    JANET DI PIETRO; Fiscal Year: 2007
    ..abstract_text> ..
  24. Adenosine-releasing brain implants for epilepsy therapy
    Detlev Boison; Fiscal Year: 2011
    ..Our SPECIFIC AIMS are: Aim 1. Engineer biocompatible polymers for the local therapeutic delivery of adenosine. Aim 2. Develop a polymer/cell based system for the sustained delivery of adenosine. ..
  25. Advanced Neuroimaging: Ethical, Legal, and Social Issues
    Judy Illes; Fiscal Year: 2005
    ..abstract_text> ..
  26. Estradiol For Neurocognitive Dysfunction After CABG
    Charles Hogue; Fiscal Year: 2005
    ..The results of this study will evaluate the efficacy and safety of an easily implemented therapy for improving neurologic outcome and quality of life after CABG surgery for postmenopausal women. ..
  27. Cortical Stimulation to Enhance Recovery after Stroke
    Randolph Nudo; Fiscal Year: 2008
    ..It is expected that this program will serve as a model for the introduction of new therapeutic approaches to brain repair that are based on underlying neuroscientific principles. ..
  28. ASSESSMENT OF DISEASE PROGRESSION IN PARKINSONISM
    David Eidelberg; Fiscal Year: 2003
    ..He will also provide structured training in the fundamentals of experimental neurological research in using new functional brain imaging techniques. ..
  29. SSB PROTEINS AS ORGANIZERS OF DNA PRECURSOR BIOSYNTHESIS
    Christopher Mathews; Fiscal Year: 2001
    ..Characterization of the phosphorylation of SSB will explore the role of this modification on protein-protein and protein-DNA associations. ..
  30. Advanced NeuroImaging for Acute Stroke Treatment
    Max Wintermark; Fiscal Year: 2007
    ..Invited junior scientists, for whom funding is requested, were selected based on merit. [unreadable] [unreadable] [unreadable]..
  31. Brain Activation in Patients with Early HIV Dementia
    Linda Chang; Fiscal Year: 2008
    ..g. neuroprotective or anti-inflammatory treatments). [unreadable] [unreadable] [unreadable]..
  32. Induction of Striatal Regeneration in Huntington's Disease
    Steven Goldman; Fiscal Year: 2009
    ....
  33. Validation of rat models for resistant epilepsy therapy
    Wolfgang Loscher; Fiscal Year: 2005
    ..Our goal is to establish standard assays that can be employed by researchers to continue the search for treatments of drug resistant epilepsy. ..
  34. Vascular Depression: Longitudinal Changes
    Warren D Taylor; Fiscal Year: 2010
    ..The proposal will provide important new data on neuroradiologic and neuropsychological factors contributing to recurrent or chronic depression in older individuals. ..
  35. Computational analysis of diffusion tensor images: application to schizophrenia
    Ragini Verma; Fiscal Year: 2010
    ....
  36. Neurocognitive Mechanisms: Appetitive & Aversive Emotion
    Gregory Miller; Fiscal Year: 2003
    ..In parallel, extensive fMRI pilot work will be conducted to optimize imaging of orbitofirontal cortex. In years 2 and 3, an emotional challenge experiment will be conducted using the improved fMRI scan parameters. ..
  37. Stroke neuroprotection with a recombinant fusion protein
    RUBEN BOADO; Fiscal Year: 2007
    ..The completion of the phase II work will enable the preparation of an IND to the FDA for testing of this novel neuroprotective agent in acute stroke in humans. [unreadable] [unreadable] [unreadable] [unreadable]..
  38. Understanding the SELENA trial: Estrogen in Lupus
    Betty Diamond; Fiscal Year: 2007
    ..It cannot be emphasized too much that this study can be performed only in the cohort of patients in the SELENA trial. Another such study will not be performed. [unreadable] [unreadable] [unreadable] [unreadable]..
  39. CHILDHOOD STIMULANT EXPOSURE IMPACT ON LATER DRUG ABUSE
    Francisco Castellanos; Fiscal Year: 2008
    ..abstract_text> ..
  40. STUDIES ON THE OLFACTORY CORTEX
    Joseph Price; Fiscal Year: 2008
    ..Drevets), to determine which specific areas and networks are affected in these disorders. ..
  41. Pilot/Phase I Study of Intrathecal Laronidase for Spinal Cord Compression in Muco
    Patricia Dickson; Fiscal Year: 2009
    ..If successful, delivery into the spinal fluid could represent a practical, straightforward method of treating central nervous system disease due to lysosomal storage. ..
  42. Collaborative Brain Mapping: Tools for Sharing
    Arthur Toga; Fiscal Year: 2008
    ..The resulting information technology will be scalable and applicable to other scientific data sharing problems. [unreadable] [unreadable]..
  43. HOW DOES ALCHOHOL SUPPRESS GLIAL NOS-2 GENE EXPRESSION
    PETER SYAPIN; Fiscal Year: 2003
    ..The results will have broad implications for understanding ethanol effects on CNS gene expression, which is proposed to underlie chronic behavioral and pathophysiologic effects of alcohol. ..
  44. Targeted Neurotrophin Drug Development in Parkinson's Disease
    RUBEN BOADO; Fiscal Year: 2008
    ..This research will lead to a new neurotrophin treatment of PD, which can be administered by intravenous or subcutaneous administration. [unreadable] [unreadable] [unreadable]..
  45. Neuroprotection in Stroke Drug Development
    RUBEN BOADO; Fiscal Year: 2008
    ..AGT-120 is the first large molecule neuroprotective that has been specifically formulated to cross the BBB in humans following intravenous administration. ..
  46. Distributed Supercomputing for Brain Mapping
    Arthur Toga; Fiscal Year: 2009
    ....
  47. XALD: Role of Very Long Chain Fatty Acyl-CoA Synthetases
    Paul Watkins; Fiscal Year: 2006
    ..Furthermore, they will facilitate elucidation of the role of enzymes belonging to the VLACS or BG families in XALD. [unreadable] [unreadable]..
  48. The modulation of adenosine by temperature, oxygen and glucose
    SUSAN MASINO; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  49. ETHANOL, INSULIN/IGF SIGNALING AND NEURONAL MIGRATION
    Suzanne de la Monte; Fiscal Year: 2008
    ..abstract_text> ..
  50. MONITORING METHAMPHETAMINE ABUSE TREATMENT WITH 1H MRS
    Linda Chang; Fiscal Year: 2001
    ..This comprehensive approach will allow us to determine the relationship between changes in cognitive function and metabolite changes in brain tissue associated with chronic methamphetamine abuse and treatment. ..
  51. Occupational Asthmagens in Cleaners: A Focus Group Study
    Ahmed Arif; Fiscal Year: 2005
    ..The information from the focus group interviews will be used to develop JEM and a draft survey instrument for use among cleaners. ..
  52. Depression in Alzheimer's Disease Study 2 (DIADS-2)
    Constantine Lyketsos; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  53. Safety of repetitive TMS in chronic subcortical stroke
    Steven Cramer; Fiscal Year: 2006
    ..The long-term goal of these studies is to develop a safe and efficacious method for facilitating motor cortex function in order to improve motor status of patients with stroke-related weakness. ..
  54. GENE-METAL INTERACTIONS AND PARKINSON'S DISEASE
    Howard Hu; Fiscal Year: 2006
    ..abstract_text> ..
  55. Effect of Alcohol on HIV-1 Immune Responses & BBB Damage
    Yuri Persidsky; Fiscal Year: 2004
    ..The ability to use an in vitro BBB and an in vivo animal model will help in defining mechanisms of disease progression in the setting of alcohol abuse. ..
  56. A Proteomic Analysis of Neural Progenitors
    Harley Kornblum; Fiscal Year: 2004
    ..It is anticipated that these pilot studies will pave the way for new avenues in the study of neural progenitor cell biology. ..
  57. Large Scale Images of Gene Transcription in MS and EAE
    Lawrence Steinman; Fiscal Year: 2004
    ..The discovery of the role of osteopontin, first identified in large scale profiles, exemplifies how this approach may help us to understand MS and to develop new therapies. ..
  58. BREATH HOLD 3D MRA OF THE CORONARY ARTERIES
    Robert Edelman; Fiscal Year: 2002
    ..The goal is to optimize the MRA method and to determine if the use of contrast agents provides any clinical benefit. ..
  59. Global vs. Focal Neuroimaging Markers of Dementia Risk
    Caterina Rosano; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  60. AUTOIMMUNITY CENTERS OF EXCELLENCE
    Betty Diamond; Fiscal Year: 2007
    ..Finally, the Center will include an administrative core for coordination and implementation of Center activities. ..
  61. EPIDEMIOLOGY AND GENETICS OF PARKINSON'S DISEASE
    Walter Rocca; Fiscal Year: 2005
    ..These three studies will contribute greatly to understanding the causes and possible prevention of PD by exploring novel hypotheses and by using innovative methods. ..
  62. Cytomegalovirus in the Brain
    Anthony N van den Pol; Fiscal Year: 2010
    ..These experiments will help us understand the mechanisms associated with CMV-induced neurological dysfunction, and how to combat the virus within the brain with minimal complications. ..
  63. Neuroprotection by Novel Regulators of mGluR Signaling
    Julie Saugstad; Fiscal Year: 2009
    ..abstract_text> ..
  64. Optimization of TMS for Depression
    Mark George; Fiscal Year: 2009
    ..This clinical site grant (CSG) proposal is one of four scientifically identical proposals resubmitted under a CSMD mechanism.] ..
  65. Brain Structure and Cognition in Cystinosis
    Doris Trauner; Fiscal Year: 2007
    ..The study results may also provide a basis for developing early interventions for children "at risk" for cognitive deficits because of the presence of a genetic disorder. ..
  66. Raloxifene in Women with AD: Randomized Controlled Trial
    VICTOR HENDERSON; Fiscal Year: 2007
    ..It is anticipated that findings from this pilot study will provide useful guidance to plan and conduct future studies of raloxifene in women with mild to moderate symptoms of dementia due to AD. ..
  67. DISPARITIES IN ASTHMA AMONG ELDERLY IN WEST TEXAS
    Ahmed Arif; Fiscal Year: 2003
    ..A similar comparison will be made to evaluate urban/rural differences. ..
  68. Role of MicroRNAs in Ischemic Tolerance
    Julie Saugstad; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  69. HIV Clade on Cognitive and Neurological Disorders Brazil
    Ronald Ellis; Fiscal Year: 2007
    ..UCSD investigators will train and guide the administration and interpretation of the clinical assessment instruments, transfer technology to the Brazilian site. [unreadable] [unreadable]..
  70. Extracellular Modulation of Metabotropic GluRs
    Julie Saugstad; Fiscal Year: 2005
    ..abstract_text> ..
  71. MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONS
    Mark George; Fiscal Year: 2002
    ..Thus, we plan to use interleaved fMRI and DBS to directly examine the effects of DBS on hypothesized brain circuits and to correlate this with immediate and longer-term (4 week) behavioral outcomes (mood and cognition). ..
  72. High Dose Erythropoetin Neuroprotection Trial for Neonatal Cardiac Surgery
    Dean Andropoulos; Fiscal Year: 2008
    ..This study will show if babies that are given erythropoetin have fewer delays in development than babies that do not receive the drug. [unreadable] [unreadable] [unreadable]..
  73. NPY DEPRESSION OF HIPPOCAMPAL EPILEPSY
    Anthony van den Pol; Fiscal Year: 2002
    ..NPY is potentially of great interest because its primary action in the normal hippocampus appears to be one of depressing hyperexcited neurons, without a substantial effect on normal neurotransmission. ..
  74. Neuro-cognitive Outcome After Early Focal Brain Damage
    Doris Trauner; Fiscal Year: 2007
    ..The findings may further serve as a basis from which to design more effective interventions for children at risk for cognitive dysfunction because of early brain damage. ..
  75. Mitochondrial control of neuronal excitotoxicity
    David Nicholls; Fiscal Year: 2005
    ..4. To test the hypothesis that mitochondria at specific intracellular locations may be selectively vulnerable to glutamate excitotoxicity because of their proximity to NMDA receptors, or their location in regions of high-energy demand. ..
  76. PEDIATRIC LOW VISION
    WILLIAM GOOD; Fiscal Year: 2002
    ..Do strabismus and anisometropia affect different visual functions differentially? Is the combination of risk-factors more amblyogenic? ..
  77. ADENOSINE AND TRAUMATIC BRAIN INJURY
    Patrick Kochanek; Fiscal Year: 2007
    ..These studies explore the most promising adenosine-based therapy for TBI-A2a receptor antagonists. Our bench to bedside track record ensures translation to the clinic. [unreadable] [unreadable]..
  78. EARLY TMT RETINOPATHY OF PREMATURITY HEADQUARTER GRANT
    WILLIAM GOOD; Fiscal Year: 2008
    ..Outcome will be determined at a 6 month post-term ophthalmologic examination and at a 9 month post-term visual assessment examination. ..
  79. The Effects of Prematurity on Visual Development
    WILLIAM GOOD; Fiscal Year: 2008
    ..A comparison of head ultrasound and DTI findings will demonstrate whether DTI should replace ultrasound for the diagnosis of neurological injury in the newborn nursery. [unreadable] [unreadable]..
  80. INTEGRATING PHYSIOLOGY AND BEHAVIOR IN REAL TIME FMRI
    JAMES VOYVODIC; Fiscal Year: 2002
    ..Integrating the strategies addressed in this study will make fMRI a more sensitive and reliable brain imaging tool, thereby extending its capabilities for a wide range of both scientific and clinical applications. ..
  81. Control of Genomic Stability by Emi1 and Securin
    NORMAN LEHMAN; Fiscal Year: 2007
    ..abstract_text> ..
  82. Aging-Related Models and Mitochondrial Bioenergetics
    David Nicholls; Fiscal Year: 2006
    ..3. To indicate therapeutic strategies whereby the deleterious consequences of aging-related changes in mitochondrial function can be minimized. ..
  83. CHRONOBIOLOGY OF PARTIAL EPILEPSY
    Mark Quigg; Fiscal Year: 2002
    ..In summary, these studies will provide insight into the chronoblological factors that facilitate partial seizure expression and may provide new perspectives into treatments for poorly controlled partial epilepsy. ..