Genomes and Genes
central nervous system diseases
Summary: Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
Publications243 found, 100 shown here
- Necrotizing neurosarcoid: three cases with varying presentationsJ M Markert
Department of Surgery, Division of Neurosurgery, University of Alabama at Birmingham, AL 35294, USA
Clin Neuropathol 26:59-67. 2007..This paper documents three additional cases of necrotizing neurosarcoid, involving a wide spectrum of central nervous system (CNS) locations...
- Central nervous system effects in acute thallium poisoningYu tai Tsai
Department of Neurology, Chang Gung Memorial Hospital and University, 199 Tung Hwa North Road, Taipei, Taiwan
Neurotoxicology 27:291-5. 2006..In addition, neuropsychological tests also confirmed memory deficits, although the brain lesions in the corpus striatum might resolve...
- Childhood chronic inflammatory demyelinating polyneuropathy with central nervous system demyelination resembling multiple sclerosisM Victoria Rodriguez-Casero
Department of Neurology, Royal Children s Hospital, Flemington Road, Parkville, VIC 3052, Australia
Neuromuscul Disord 13:158-61. 2003..To our knowledge, this association has not been previously described in the English literature in childhood...
- Metabolomics: a global biochemical approach to the study of central nervous system diseasesRima Kaddurah-Daouk
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Neuropsychopharmacology 34:173-86. 2009..Metabolomics emerges as another powerful tool in central nervous system research...
- Circulating microRNAs: a novel class of potential biomarkers for diagnosing and prognosing central nervous system diseasesXue Feng Jin
Beijing Institute of Pharmacology and Toxicology, Beijing, China
Cell Mol Neurobiol 33:601-13. 2013....
- Human enterovirus 71 disease in Sarawak, Malaysia: a prospective clinical, virological, and molecular epidemiological studyMong How Ooi
Department of Paediatrics, Sibu Hospital, Sibu, Malaysia
Clin Infect Dis 44:646-56. 2007..Human enterovirus (HEV)-71 causes large outbreaks of hand-foot-and-mouth disease with central nervous system (CNS) complications, but the role of HEV-71 genogroups or dual infection with other viruses in causing severe disease is unclear...
- The chronic cerebrospinal venous insufficiency syndromeP Zamboni
Vascular Disease Centre, Interventional Radiology Unit, University of Ferrara, 44100 Ferrara, Italy
Phlebology 25:269-79. 2010..Restenosis rate was found out elevated in the IJVs, but negligible in the AZ. However, PTA seems to positively influence clinical and QoL parameters of the associated MS and warrants further randomized control trials...
- Neural cell cycle dysregulation and central nervous system diseasesWei Wang
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
Prog Neurobiol 89:1-17. 2009..This review summarizes advances in findings implicating cell cycle machinery in neuronal death in CNS diseases...
- Antioxidants in central nervous system diseases: preclinical promise and translational challengesChandrashekhar D Kamat
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
J Alzheimers Dis 15:473-93. 2008....
- Endovascular treatment for chronic cerebrospinal venous insufficiency: is the procedure safe?T Ludyga
EUROMEDIC Specialist Clinics, Department of Vascular and Endovascular Surgery, Katowice, Poland
Phlebology 25:286-95. 2010..Although balloon angioplasty and stenting seem to be safe procedures, there are currently no data on the treatment of a large group of patients with this vascular pathology...
- Delivery of neurotrophic factors to the central nervous system: pharmacokinetic considerationsR G Thorne
Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota, USA
Clin Pharmacokinet 40:907-46. 2001....
- Detection of myelin autoantibodies: evaluation of an assay system for diagnosis of multiple sclerosis in differentiation from other central nervous system diseasesMarkus Langkamp
Mediagnost Gesellschaft für Forschung und Herstellung von Diagnostika GmbH, Reutlingen, Germany
Clin Chem Lab Med 47:1395-400. 2009..This tool could help define autoimmune status and thus be a potential means of therapeutic surveillance...
- Vascular inflammation in central nervous system diseases: adhesion receptors controlling leukocyte-endothelial interactionsBarbara Rossi
Department of Pathology and Diagnostics, Section of General Pathology, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
J Leukoc Biol 89:539-56. 2011..These emerging roles for leukocytes and leukocyte adhesion mechanisms in CNS diseases provide insight into the mechanisms of brain damage and may contribute to the development of novel therapeutic strategies...
- Isoprostanes as biomarkers and mediators of oxidative injury in infant and adult central nervous system diseasesAnita Greco
Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
Curr Neurovasc Res 1:341-54. 2004..biomarkers to investigate the involvement of oxidative stress in the pathogenesis of infant and adult central nervous system diseases. In addition to isoprostanes, a new class of free radical-mediated peroxidation products, named ..
- Neurosarcoidosis in a patient with rheumatoid arthritis during treatment with infliximabGunnar Sturfelt
J Rheumatol 34:2313-4. 2007
- Purkinje cell cytoplasmic autoantibody type 1 accompaniments: the cerebellum and beyondAndrew McKeon
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Arch Neurol 68:1282-9. 2011..To investigate the full extent of Purkinje cell cytoplasmic autoantibody type 1 autoimmunity (classically associated with paraneoplastic cerebellar degeneration) from clinical, immunohistochemical, and neuropathological perspectives...
- Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6I L Campbell
Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037
Proc Natl Acad Sci U S A 90:10061-5. 1993..These findings indicate that cytokines such as IL-6 can have a direct pathogenic role in inflammatory, infectious, and neurodegenerative CNS diseases...
- The role of imaging in proof of concept for CNS drug discovery and developmentDean F Wong
Johns Hopkins University School of Medicine, Johns Hopkins University School of Medicine, 601 North Caroline St, JHOC room 3245, Baltimore, MD 21287 0807, USA
Neuropsychopharmacology 34:187-203. 2009..In summary, this article reviews the vital biomarker approach of neuroimaging in proof of concept studies...
- Inner ear lesions in congenital cytomegalovirus infection of human fetusesNatacha Teissier
Pediatric ENT Department, Robert Debre Hospital, APHP, Paris, France
Acta Neuropathol 122:763-74. 2011..In addition, the occurrence of SNHL depends on the intensity and duration of the viral infection and inflammation...
- Altered development of the brain after focal herpesvirus infection of the central nervous systemThad Koontz
Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Exp Med 205:423-35. 2008..These findings suggested that in the developing CNS, focal virus infection and induction of inflammatory responses in resident and infiltrating mononuclear cells resulted in delayed cerebellar morphogenesis...
- Purinergic signalling and disorders of the central nervous systemGeoffrey Burnstock
Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
Nat Rev Drug Discov 7:575-90. 2008....
- Dysfunctional cell-cell signaling in the neurovascular unit as a paradigm for central nervous system diseaseShuzhen Guo
Neuroprotection Research Laboratory, MGH East 149 2401, 13th Street, Charlestown, MA 02129, USA
Stroke 40:S4-7. 2009..This minireview surveys recent data that support this basic idea, with examples drawn from experimental models broadly relevant to stroke and neurodegeneration...
- Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000)L F Eng
Department of Pathology, VAPA Health Care System, Palo Alto 94304, USA
Neurochem Res 25:1439-51. 2000..While the structural function of GFAP has become more acceptable, the use of GFAP antibodies and promoters continue to be valuable in studying CNS injury, disease, and development...
- Inflammation in the CNS: balance between immunological privilege and immune responsesM K Matyszak
CNR, Centre of Cellular and Molecular Pharmacology, Milano, Italy
Prog Neurobiol 56:19-35. 1998..Pathogens injected into the ventricles induce inflammatory responses similar to those in other non-CNS tissues: there is an acute inflammatory response which develops spontaneously into an immune mediated response within the first week...
- Dysfunctional astrocytes as key players in the pathogenesis of central nervous system disordersJacques de Keyser
Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
J Neurol Sci 267:3-16. 2008..Targeting astrocyte dysfunction may lead to new therapeutic strategies for these disorders...
- Molecular pathogenesis of neuroinflammationM Bradl
Institute for Brain Research, Department of Neuroimmunology, Vienna, Austria
J Neurol Neurosurg Psychiatry 74:1364-70. 2003..The review is limited to the inflammatory reactions of the central nervous system that occur in multiple sclerosis and experimental autoimmune encephalomyelitis...
- Are circulating monocytes as microglia orthologues appropriate biomarker targets for neuronal diseases?Gerd Schmitz
Institute for Clinical Chemistry and Laboratory Medicine, University Hospital of Regensburg, Germany
Cent Nerv Syst Agents Med Chem 9:307-30. 2009..They are suitable biomarker targets for diagnosis and prognosis and maybe also therapy of central nervous system disease...
- Changing incidence of central nervous system diseases in the EuroSIDA cohortAntonella d'Arminio Monforte
Institute of Infectious and Tropical Diseases, University of Milan, I Sacco Hospital, Via GB Grassi 74, 20157 Milan, Italy
Ann Neurol 55:320-8. 2004....
- Abnormal hyperintensity within the subarachnoid space evaluated by fluid-attenuated inversion-recovery MR imaging: a spectrum of central nervous system diseasesMasayuki Maeda
Department of Radiology, Mie University School of Medicine, 2 174 Edobashi, Tsu, 514 8507 Mie, Japan
Eur Radiol 13:L192-201. 2003..This knowledge is helpful in establishing the correct diagnosis...
- Potential involvement of the extracranial venous system in central nervous system disorders and agingRobert Zivadinov
Buffalo Neuroimaging Analysis Center, Department of Neurology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA
BMC Med 11:260. 2013..The idea has been changing with regards to the extracranial venous system...
- CD8+ T lymphocytes control murine cytomegalovirus replication in the central nervous system of newborn animalsGlenn R B Bantug
Department of Microbiology, University of Alabama at Birmingham, Alabama 35294, USA
J Immunol 181:2111-23. 2008..In summary, these results show that functionally mature virus-specific CD8(+) T cells are recruited to the CNS in mice infected with MCMV as neonates...
- Venous endothelial injury in central nervous system diseasesJonathan S Alexander
Department of Molecular and Cellular Physiology, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
BMC Med 11:219. 2013....
- Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander diseaseM Brenner
Department of Neurobiology, University of Alabama Birmingham, Birmingham, Alabama, USA
Nat Genet 27:117-20. 2001..Alexander disease therefore represents the first example of a primary genetic disorder of astrocytes, one of the major cell types in the vertebrate CNS...
- Distinction and temporal stability of conformational epitopes on myelin oligodendrocyte glycoprotein recognized by patients with different inflammatory central nervous system diseasesMarie C Mayer
Institute of Clinical Neuroimmunology, Ludwig Maximilians University, 81377 Munich, Germany
J Immunol 191:3594-604. 2013..The majority of human anti-MOG Abs did not recognize rodent MOG, which has implications for animal studies. Our findings might assist in future detection of potential mimotopes and pave the way to Ag-specific depletion. ..
- Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseasesJi Yin Zhou
Base for Drug Clinical Trial, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
Fitoterapia 83:617-26. 2012..It requires more in vivo validations and further investigations of antihypertensive and neuroprotective mechanisms of isorhynchophylline...
- The therapeutic potential of sigma (σ) receptors for the treatment of central nervous system diseases: evaluation of the evidenceSamuel D Banister
Brain and Mind Research Institute, 100 Mallett St, Camperdown, NSW 2050, Australia
Curr Pharm Des 18:884-901. 2012..This review will assess the validity of receptors as a target for various CNS diseases based on evidence from animal models of human diseases, preclinical studies in humans, and full clinical trials...
- Therapeutic potential of small interfering RNA for central nervous system diseasesAmy E Lovett-Racke
Department of Neurology, UT Southwestern Medical Center, Dallas, Tex 75390 9036, USA
Arch Neurol 62:1810-3. 2005
- Brain-derived neurotrophic factor as a drug target for CNS disordersSophie Pezet
Novartis Institute for Medical Science, London, UK
Expert Opin Ther Targets 8:391-9. 2004..The cellular and molecular mechanism by which BDNF might be a therapeutic strategy are critically examined...
- Neuro-immune crosstalk in CNS diseasesM Kerschensteiner
Institute of Clinical Neuroimmunology, Ludwig Maximilians University Munich, Marchioninistr 17, 81377 Munich, Germany
Neuroscience 158:1122-32. 2009..It is thus the balance between destructive and protective factors that ultimately determines the net result of the neuro-immune interaction...
- Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cellsDerek D C Ireland
The Cleveland Clinic, 2500 Euclid Avenue, NC30, Cleveland, OH 44195, USA
J Virol 82:300-10. 2008..By limiting early viral replication and tropism, IFN-I controls the balance of viral replication and immune control in favor of CD8 T-cell-mediated protective functions...
- Multiple roles of chemokine CXCL12 in the central nervous system: a migration from immunology to neurobiologyMeizhang Li
Neuroinflammation Research Center, Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Mail Code NC30, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Prog Neurobiol 84:116-31. 2008....
- Astrocyte intermediate filaments in CNS pathologies and regenerationMilos Pekny
Department of Medical Biochemistry, Sahlgrenska Academy at Goteborg University, Box 430, 405 30 Goteborg, Sweden
J Pathol 204:428-37. 2004..GFAP is the principal astrocyte intermediate filament protein and dominant mutations in the GFAP gene have been shown to lead to Alexander disease, a fatal neurodegenerative condition in humans...
- Influence of HAART on HIV-related CNS disease and neuroinflammationI C Anthony
Neuropathology Unit, University of Edinburgh, Alexander Donald Building, Western General Hospital, Edinburgh, Scotland
J Neuropathol Exp Neurol 64:529-36. 2005..We conclude that there is a surprising degree of ongoing neuroinflammation in HAART-treated patients, particularly in the hippocampus. This may pose a threat for the future health of individuals maintained long-term on HAART therapy...
- Microglial cell population dynamics in the injured adult central nervous systemRune Ladeby
Medical Biotechnology Center, University of Southern Denmark, Odense C
Brain Res Brain Res Rev 48:196-206. 2005....
- Risks for central nervous system diseases among mobile phone subscribers: a Danish retrospective cohort studyJoachim Schüz
Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
PLoS ONE 4:e4389. 2009..Identification of the factors that result in a healthy cohort might be of interest for elucidation of the etiology of these diseases...
- Practice guidelines for the management of cryptococcal disease. Infectious Diseases Society of AmericaM S Saag
University of Alabama at Birmingham, 35294 2050, USA For the Mycoses Study Group Cryptococcal Subproject
Clin Infect Dis 30:710-8. 2000..In all cases of cryptococcal meningitis, careful attention to the management of intracranial pressure is imperative to assure optimal c..
- Extracellular matrix degradation by metalloproteinases and central nervous system diseasesA Lukes
Department of Neurology, University of New Mexico School of Medicine, Albuquerque, USA
Mol Neurobiol 19:267-84. 1999..Agents that affect the proteolytic process at any of the regulating sites are potentially useful in therapy...
- Cyclooxygenases in central nervous system diseases: a special role for cyclooxygenase 2 in neuronal cell deathSteven H Graham
Geriatric Research Educational and Clinical Center, Veterans Affairs Pittsburgh Health Care System, and the Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15240, USA
Arch Neurol 60:628-30. 2003
- Analysis of outcome for patients with mass lesions of the central nervous system due to Langerhans cell histiocytosis treated with 2-chlorodeoxyadenosineGirish Dhall
Children s Hospital Los Angeles, Los Angeles, California, USA
Pediatr Blood Cancer 50:72-9. 2008..To assess the activity and tolerability of 2-chlorodeoxyadenosine (2-CDA) in treating mass lesions of the central nervous system (CNS) due to Langerhans cell histiocytosis (LCH)...
- Mechanisms of immunopathology in murine models of central nervous system demyelinating diseaseAnne M Ercolini
Department of Microbiology Immunology and Interdepartmental Immunobiology Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
J Immunol 176:3293-8. 2006..This review will discuss the immunopathologic mechanisms involved in these demyelinating disease models...
- Effects of streptozotocin-diabetes on the hippocampal NMDA receptor complex in ratsF Gardoni
Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, University of Milano, Milan, Italy
J Neurochem 80:438-47. 2002..These findings strengthen the hypothesis that altered post-synaptic glutamatergic transmission is related to deficits in learning and plasticity in this animal model...
- Drug Insight: steroids in CNS infectious diseases--new indications for an old therapyMichael T Fitch
Department of Neurology, Center of Infection and Immunity Amsterdam, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
Nat Clin Pract Neurol 4:97-104. 2008....
- The ubiquitin-proteasome system and proteasome inhibitors in central nervous system diseasesImtiaz M Shah
Neurological Section, SMDN Center for Cardiovascular Medicine and Cerebrovascular Disease Prevention, I 67039 Sulmona AQ, Italy
Cardiovasc Hematol Disord Drug Targets 7:250-73. 2007....
- 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in the treatment of central nervous system diseasesJoshua Z Willey
Department of Neurology, Columbia University, New York, NY 10032, USA
Arch Neurol 67:1062-7. 2010....
- Glycogen synthase kinase 3: a drug target for CNS therapiesRatan V Bhat
AstraZeneca R and D, Sodertalje, B213 231B, Sweden 151 85
J Neurochem 89:1313-7. 2004..In the present review, we summarize the properties of GSK3, and discuss the potential for such a therapy in AD, and other CNS disorders...
- Blockers of voltage-gated sodium channels for the treatment of central nervous system diseasesIstván Tarnawa
Department of Electrophysiology, Pharmacology and Drug Safety Research, Budapest, 10, POB 27, Hungary
Recent Pat CNS Drug Discov 2:57-78. 2007..Such agents may offer a breakthrough in the treatment of a variety of central nervous system diseases. This review focuses on the current trends in sodium channel research, surveying the traditional and ..
- Transplantation of bone marrow stromal cells for treatment of central nervous system diseasesMichael Chopp
Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, USA
Adv Exp Med Biol 585:49-64. 2006
- Cerebrospinal fluid Diacron-Reactive Oxygen Metabolite levels in pediatric patients with central nervous system diseasesGaku Yamanaka
Department of Pediatrics, Tokyo Medical University, Shinjuku, Tokyo, Japan
Pediatr Neurol 39:80-4. 2008This study assessed the validity of cerebrospinal fluid oxidative status of pediatric patients with central nervous system diseases, using the Diacron-Reactive Oxygen Metabolites test (d-Roms; Diacron International s.r.l...
- [Olfactory ensheathing cells transplantation for central nervous system diseases in 1,255 patients]Hongyun Huang
Beijing Hongtianji Neuroscience Academy, Beijing, 100144, P R China
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 23:14-20. 2009To analyze the therapeutic effect of olfactory ensheathing cells (OECs) transplantation for central nervous system diseases.
- Central nervous system-related symptoms and findings are common in acute Puumala hantavirus infectionTimo Hautala
Department of Internal Medicine, Oulu University Hospital, Oulu, Finland
Ann Med 42:344-51. 2010..Recent case reports and retrospective studies suggest that NE may damage the pituitary gland. Based on these observations, our goal was to explore the nature of this complication prospectively...
- Molecular mechanisms of axonal damage in inflammatory central nervous system diseasesHarald Neumann
Neuroimmunology Unit, European Neuroscience Institute Göttingen, Gottingen, Germany
Curr Opin Neurol 16:267-73. 2003..Axonal injury has attracted considerable interest during the past few years because the degree of axonal damage appears to determine long-term clinical outcome...
- Microglia as mediators of inflammatory and degenerative diseasesF Gonzalez-Scarano
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104 6146, USA
Annu Rev Neurosci 22:219-40. 1999..In this review we discuss the role of microglia in three diseases in which their activity is at least partially deleterious: HIV, multiple sclerosis, and Alzheimer's disease...
- Inflammation in the central nervous system: the role for dendritic cellsMikhail Pashenkov
Neuroimmunology Unit, Division of Neurology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
Brain Pathol 13:23-33. 2003..CNS DCs can therefore be viewed as a future therapeutic target in chronic inflammatory diseases such as multiple sclerosis...
- Analysis of cerebrospinal fluid cells by flow cytometry and immunocytochemistry in inflammatory central nervous system diseases: comparison of low- and high-density cell surface antigen expressionA Windhagen
Laboratory of Neuroimmunology, Department of Neurology, Medical School Hannover, Hannover, Germany
Diagn Cytopathol 21:313-8. 1999..We conclude that for examination of low-density surface markers on CSF cells, particularly with low cell counts, immunocytochemistry may be more reliable...
- The application of platelet-rich plasma may be a novel treatment for central nervous system diseasesYi Xin Shen
Department of Orthopaedics, the Second Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province 215004, PR China
Med Hypotheses 73:1038-40. 2009....
- The complement system in central nervous system diseasesH Rus
Department of Pathology, University of Maryland, School of Medicine, Baltimore 21201, USA
Immunol Res 24:79-86. 2001..These findings indicate that complement activation and membrane assembly of C5b-9 play an important role in pathogenesis of central nervous system (CNS) disorders...
- Electromagnetic fields and health effects--epidemiologic studies of cancer, diseases of the central nervous system and arrhythmia-related heart diseaseChristoffer Johansen
Department of Psychosocial Cancer Research, Institute of Cancer Epidemiology, The Danish Cancer Society, Copenhagen, Denmark
Scand J Work Environ Health 30:1-30. 2004..At present, there is little, if any, evidence that the use of mobile phones is associated with cancer in adults, including brain tumors, acoustic neuroma, cancer of the salivary glands, leukemia, or malignant melanoma of the eye...
- Comparison of Roche MONITOR and Organon Teknika NucliSens assays to quantify human immunodeficiency virus type 1 RNA in cerebrospinal fluidP Spearman
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Clin Microbiol 39:1612-4. 2001..Results of 282 assays were highly correlated (r = 0.826), with MONITOR values being 0.29 +/- 0.4 log(10) copies/ml (mean +/- standard deviation) values. Both assays can reliably quantify HIV-1 RNA in CSF...
- Human herpes virus type 7 DNA in the cerebrospinal fluid of children with central nervous system diseasesA Pohl-Koppe
Children s Hospital, Ludwig Maximilians University Munich, Germany
Eur J Pediatr 160:351-8. 2001..These children were diagnosed with aseptic meningitis (n = 1), viral encephalitis/meningoencephalitis (n = 2), facial palsy (n = 1), vestibular neuritis (n = 1) and febrile seizure (n = 1)...
- Aging and neuro-AIDS conditions and the changing spectrum of HIV-1-associated morbidity and mortalityK Goodkin
Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, 1400 NW 10th Ave, 803 A, Miami, FL 33136, USA
J Clin Epidemiol 54:S35-43. 2001..Age associations with incidence of these disorders and with treatment foci are specified. Implications for future changes in management are discussed...
- Borna disease virusI Jordan
Emerging Diseases Laboratory, Department of Neurology, University of California-- Irvine, Irvine, California 92697-4292, USA
Rev Med Virol 11:37-57. 2001..Experimental Borna disease in neonatal and adult rats provides an intriguing model for immune-mediated disturbances of brain development and function...
- Matrix metalloproteinases and diseases of the central nervous system with a special emphasis on ischemic brainYvan Gasche
Department of Fundamental Neuroscience, Geneva University Hospital, Geneva Medical School, 1211 Geneva, Switzerland
Front Biosci 11:1289-301. 2006..Yet MMPs may have a detrimental or beneficial role depending on the stage of brain injury. Simple therapeutic strategies based on MMP inhibition have thus little chance to favorably alter prognosis...
- Nonmuscular involvement in merosin-negative congenital muscular dystrophyH Jacobus Gilhuis
Department of Paediatric Neurology, Neuromuscular Centre, University Medical Centre St Radboud, 6500 HB Nijmegen, The Netherlands
Pediatr Neurol 26:30-6. 2002..The pattern of myelination of the brain and nerve conduction slowing suggests a myelination arrest. Merosin deficiency can give rise to a congestive cardiomyopathy, which is of no clinical relevance in the majority of children...
- Neural stem cells in the adult nervous systemDaniele Bottai
Stem Cell Research Institute, DIBIT, Fondazione Centro San Raffaele del Monte Tabor, 20132 Milan, Italy
J Hematother Stem Cell Res 12:655-70. 2003....
- Frequency and spectrum of central nervous system involvement in 193 children with haemophagocytic lymphohistiocytosisAnnacarin Horne
Childhood Cancer Research Unit, Department of Woman and Child Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Br J Haematol 140:327-35. 2008..Prompt treatment of HLH at onset or relapse may reduce these complications...
- [Nervous system involvement in children suffering from disorders associated with vasculitis]Marek Kacinski
Klinika Neurologii Dzieciecej, Wydział Lekarski Collegium Medicum, Uniwersytet Jagiellonski, ul Wielicka 265, 30 663 Krakow
Neurol Neurochir Pol 38:S9-15. 2004..The most frequent form of these disorders was ischaemic stroke. Authors discussed issues specific for developmental diagnostic, etiopathogenetic and therapeutic topics...
- Initial evaluations for multiple sclerosis in a university multiple sclerosis center: outcomes and role of magnetic resonance imaging in referralMario J Carmosino
University of Colorado Multiple Sclerosis Center, University of Colorado School of Medicine, Denver, 80262, USA
Arch Neurol 62:585-90. 2005..To evaluate diagnostic outcomes, especially as they relate to reason for referral, of patients referred to a university-based multiple sclerosis (MS) center for possible MS...
- Multiple sclerosis mimicsRobert M Herndon
Department of Neurology, University of Mississippi Medical School, Jackson, USA
Adv Neurol 98:161-6. 2006..In addition to the cost of treatment, many of the current treatments such as Mitoxantrone (Novantrone) are not benign and we should not subject our patients to unnecessary harmful therapies...
- Striatal delivery of rAAV-hAADC to rats with preexisting immunity to AAVLaura M Sanftner
Avigen, Inc, Alameda, CA 94502, USA
Mol Ther 9:403-9. 2004..These results have important implications for gene therapy for CNS disorders...
- Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathwayLina Du
Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
J Biol Chem 279:38563-70. 2004....
- Neurological deficit and disturbances in higher nervous activity during modeling of perinatal hypoxic-ischemic damage to the central nervous system in rat pupsS V Lebedev
V P Serbskii State Research Center for Social and Forensic Psychiatry, Moscow
Bull Exp Biol Med 136:242-5. 2003..The size of the ipsilateral hemisphere remained low in adult animals...
- Neuron-astrocyte interactions: partnership for normal function and disease in the central nervous systemEduardo E Benarroch
Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
Mayo Clin Proc 80:1326-38. 2005..Disturbances of these neuron-astrocyte interactions are likely to play an important role in neurologic disorders including cerebral ischemia, neurodegeneration, migraine, cerebral edema, and hepatic encephalopathy...
- Neurogenesis in the adult central nervous systemPhilippe Taupin
National Neuroscience Institute, Singapore, 11 Jalan Tan Tock Seng, Singapore 308433
C R Biol 329:465-75. 2006..Thus, not only neurogenesis contributes to reshaping the adult brain, it will ultimately lead us to redefine our knowledge and understanding of the nervous system...
- BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal developmentYihru Fannjiang
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Dev Cell 4:575-85. 2003..BAK can alter neurotransmitter release in a direction consistent with its protective effects on neurons and mice. These findings suggest that BAK inhibits cell death by modifying neuronal excitability...
- Frameshift mutation in GJA12 leading to nystagmus, spastic ataxia and CNS dys-/demyelinationNicole I Wolf
Clinical and Molecular Genetics Unit, Institute of Child Health, London, UK
Neurogenetics 8:39-44. 2007..In children with nystagmus, ataxia and dysmyelination, mutation analysis of GJA12 should be considered early, especially if inheritance is autosomal recessive...
- Cytochrome C release from CNS mitochondria and potential for clinical intervention in apoptosis-mediated CNS diseasesRonald Jemmerson
Department of Microbiology and Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Antioxid Redox Signal 7:1158-72. 2005..Because of their distinct mechanisms for Cyt c release, both the mPT and proapoptotic proteins should be targeted for effective clinical intervention in CNS disorders involving apoptosis...
- Magnetic resonance imaging of neural circuitsJeff Duyn
Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA
Nat Clin Pract Cardiovasc Med 5:S71-8. 2008..At present, few MRI data characterizing the neural circuits in the heart are available, but in this Article we discuss the applicable present developments and the prospects for the future...
- TNFalpha in experimental diseases of the CNSRoberto Furlan
Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
Methods Mol Med 98:171-90. 2004..The application of innovative research strategies or original therapeutic approaches to these experimental models may be rewarding in terms of advancement in a field that is crucial for the management of many human patients...
- Chemokines and brain functionsGhazal Banisadr
INSERM U 732 UPMC, Hopital Saint Antoine, 184 rue du Faubourg Saint Antoine, 75571 Paris Cedex 12, France
Curr Drug Targets Inflamm Allergy 4:387-99. 2005....
- Magnetic resonance imaging of the central nervous system in children with a new nonionic gadolinium contrast agent--gadoteridol injection (ProHance)S E Byrd
Department of Radiology, Children s Memorial Hospital, Chicago, IL 60614
J Natl Med Assoc 85:361-6. 1993..Gadoteridol injection is a safe and excellent contrast agent for use in MRI...
- Neuroimaging of central nervous system infectionsJ V Hunter
Department of Radiology, Baylor College of Medicine, Texas Children s Hospital, Houston, TX 77030, USA
Semin Pediatr Infect Dis 14:140-64. 2003....
- Phenotypic variation among brothers with the McLeod neuroacanthocytosis syndromeRuth H Walker
Departments of Neurology, Veterans Affairs Medical Center, New York, New York 10468, USA
Mov Disord 22:244-8. 2007..This phenotypic variation, despite shared mutations, suggests the action of disease-modifying factors that may explain some of the difficulties with genotype-phenotype correlation in McLeod syndrome...
- From fish to man: understanding endogenous remyelination in central nervous system demyelinating diseasesMonique Dubois-Dalcq
National Institute of Neurological Disorders and Stroke, Porter Neuroscience Research Center, Bethesda, MD 20892 3706, USA
Brain 131:1686-700. 2008..We propose that expansion of this research field will help find ways to maintain or enhance spontaneous remyelination in man...
- TWEAK and the central nervous systemManuel Yepes
Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA
Mol Neurobiol 35:255-65. 2007..In addition, inhibition of TWEAK activity by either treatment with a Fn14-Fc fusion protein or neutralizing anti-TWEAK antibodies has shown therapeutic efficacy in animal models of ischemic stroke, cerebral edema, and multiple sclerosis...
- Ill-defined neurological syndromes with autoimmune background: a diagnostic challengeClio P Mavragani
Department of Pathophysiology, National University of Athens, Greece
J Rheumatol 34:341-5. 2007..To define the diagnostic features of a cohort of patients presenting with autoimmune manifestations and atypical neurological features not fulfilling criteria for a well defined neurological or connective tissue disorder...
- First episode of acute CNS inflammatory demyelination in childhood: prognostic factors for multiple sclerosis and disabilityYann Mikaeloff
Service de Neurologie Pediatrique, Hopital Roger Salengro, Lille, France
J Pediatr 144:246-52. 2004..To evaluate prognostic factors for second attack and for disability in children presenting with an initial episode of central nervous system (CNS) demyelination...
- Is optic neuritis more benign than other first attacks in multiple sclerosis?Mar Tintore
Unit of Clinical Neuroimmunology, Department of Neurology, Hospital Universitari Vall d Hebron, Barcelona, Spain
Ann Neurol 57:210-5. 2005..Optic neuritis has a smaller risk for conversion to multiple sclerosis. Nevertheless, MRI at baseline, not CIS topography, appears to be the crucial issue at multiple sclerosis presentation...
- An exploratory study of ferumoxtran-10 nanoparticles as a blood-brain barrier imaging agent targeting phagocytic cells in CNS inflammatory lesionsSándor P Manninger
Department of Radiology, Oregon Health and Science University, Portland, OR, USA
AJNR Am J Neuroradiol 26:2290-300. 2005....
- Immune reconstitution inflammatory syndrome of the brain: case illustrations of a challenging entityElisabeth J Rushing
Department of Neuropathology and Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, District of Columbia 20306 6000, USA
J Neuropathol Exp Neurol 67:819-27. 2008..In this study, the degree of CD8+ inflammation was more pronounced in the single fatal example, and mast cells were not identified in the infiltrates. Although nonspecific, imaging findings may offer clues to early diagnosis...
- Trigeminal neuralgia in a patient with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)Selcuk Peker
Department of Neurosurgery, Marmara University, Marmara University Neurological Sciences Institute, Istanbul, Turkey
J Clin Neurosci 12:172-4. 2005..To our knowledge, this is the first case in the literature of MNGIE with trigeminal neuralgia. An analogy is suggested between multiple sclerosis and MNGIE as a cause for trigeminal neuralgia in this patient...
- Inflammatory and reparative tissue reaction in developing human central nervous systemMaria Dambska
Department of Experimental and Clinical Neuropathology, Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego St, 02 106 Warsaw, Poland
Acta Neurobiol Exp (Wars) 64:475-80. 2004..The topography of maturing brain lesions due to infections and anoxic/ischemic damage was similar and localized most often in the periventricular white matter...
- Human embryonic stem cell-derived neural crest stem cells and Hirschsprung diseaSean J Morrison; Fiscal Year: 2010..Transplantation/methods/*trends</keyword;keyword>Central Nervous System Diseases/*therapy</keyword;keyword>Cerebrovascular Accident/therapy</keyword;keyword>Clinical ..
- Dynamics of Kinesins, Dyneins, and MyosinsPaul R Selvin; Fiscal Year: 2010..as a function of insertion length of the cargo-binding domain of myosin VI (with L. Sweeney, UPenn.). d) Technological developments: Optics/microscopy needs to be achieved to fulfill the above goals. ..
- Brain Delivery of Nanoformulated Superoxide DismutaseErin G Rosenbaugh; Fiscal Year: 2013..In addition to the proposed scientific research, this fellowship will support the applicant's participation in nanotechnology-based coursework and career development. ..
- The Role of the Terminal Complement Pathway in ALSScott R Barnum; Fiscal Year: 2013..immune system, drives neuroinflammation along with other inflammatory mediators in most, if not all, central nervous system diseases and infections. There is growing evidence that complement contributes to neurodegeneration in ALS...
- Control of Drug Delivery to the CNS: Modulating P-glycoprotein ActivityWilliam A Banks; Fiscal Year: 2013..abstract_text> ..
- Regulation of HIV-1 by Rad51 in CNS cellsKamel Khalili; Fiscal Year: 2013..The identification of novel host-viral interaction pathways can provide important information regarding the pathogenesis of AIDS/CNS disease and promote the development of more effective therapeutic strategies. ..
- Air pollution and the brain: gender as an important determinant of susceptibilityLucio G Costa; Fiscal Year: 2013....
- Analysis of alphaVbeta8 Integrin In GliomagenesisJoseph H McCarty; Fiscal Year: 2012..These results may identify new therapeutic targets to treat or prevent the development of gliomas in humans. ..
- HIV-CNS Diseases and Parasitic Zoonoses in the Eastern Cape, South AfricaHELENE CARABIN; Fiscal Year: 2010..Learning more about the parasitic infection/HIV interaction could better prevent neurological disease in people with HIV. ..
- Role of ABC efflux transporters in ALSDavide Trotti; Fiscal Year: 2013..In this application we propose to study the regulation and role of these ABC transporters in ALS. Our ultimate goal is to understand the pathogenic mechanisms of ALS to improve the chances of success of pharmacotherapy for this disease. ..
- Innate immunity in Rett pathology and repairJonathan Kipnis; Fiscal Year: 2013....
- Small-molecule probes of chromatin-mediated neuroplasticityStephen J Haggarty; Fiscal Year: 2013..These multidisciplinary studies will shed new light on molecular mechanisms of brain plasticity and the relevance of these mechanisms to the development of novel therapeutics for their treatment of memory and mood disorders. ..
- Theiler?s virus as a potential cause of Vilyuisk encephalitisHOWARD LEE LIPTON; Fiscal Year: 2010..The murine counterpart, Theiler's murine encephalomyelitis virus, provides a highly relevant experimental animal model for multiple sclerosis. ..
- Human Blood-Brain Barrier Model for CNS Drug TranslationEric V Shusta; Fiscal Year: 2010..Finally, a detailed understanding of EGFR inhibitor permeability and efficacy using the human BBB model along with brain tumor isolates could have substantial impact on the translation of this class of medicines to the clinic. ..
- MR and BL Tracking of Stem/Progenitor Cells in the CNSJeff W Bulte; Fiscal Year: 2013..The ultimate goal is to develop ways of reporting on successful cell transplantation without removing any tissue, and to provide neurologists with a means to evaluate stem cell treatment in their patients. ..
- Treatment for Dysmyelination in PMD and SPG2Pamela E Knapp; Fiscal Year: 2013..Further, the strategy of silencing developed here should be applicable to other diseases involving dominant, negative mutations. ..
- Preclinical Alzheimers Disease Drug Development of Novel MAPK InhibitorsDANIEL MARTIN WATTERSON; Fiscal Year: 2013..falls well within this timeline and offers the potential for new molecular entity (NME) entry into the multi-drug arsenal needed to delay onset, slow progression, and treat existing AD across the long timeline of disease progression ..
- Radiolabled MAO-B Substrates for ImagingMichael R Kilbourn; Fiscal Year: 2012..The overall goal of the project is to identify appropriate radiolabeled substrates that can be further evaluated and validated for applications in human PET imaging. ..
- ALTERATIONS IN ADULT NEUROGENESIS DURING WEST NILE VIRUS ENCEPHALITISMICHAEL JOHN VASEK; Fiscal Year: 2013..Furthermore, knowledge about the behavior of neural stem cells within inflamed conditions may help guide the development of stem cell-based therapeutics for other CNS diseases with inflammation. ..
- Overcoming Membrane Transporters to Improve CNS Drug TherapyRobert S B Clark; Fiscal Year: 2013....
- The role of VWF and platelets in BBB alterations associated with hypoxiaGEORGETTE LEILA SUIDAN; Fiscal Year: 2013....
- Identification of Biomarkers for BBB Injury-Induced by Drugs and HIV-1 ProteinsSheng He Huang; Fiscal Year: 2013..2). Determine the correlation between disease-specific BBB injury and blood levels of biomarkers by molecular typing and single-cell profiling of cBMEC. ..
- Citicoline Treatment of Methamphetamine DependencePERRY FRANKLIN RENSHAW; Fiscal Year: 2010..The complementary measures of both neuropsychological function and multimodal neuroimaging following an 8-week citicoline trial will provide new insights and treatment strategies for this significant public health concern. ..
- Lipid electrophile adduction of Pin1 and effects on substrate binding &activityChristopher D Aluise; Fiscal Year: 2013..Oxidative damage to cellular lipids is a contributing factor to aging, as well as many peripheral and central nervous system diseases. Reactive oxygen species-induced modification of polyunsaturated fatty acids results in the ..
- Nogo's role in intracellular traffickingNoam Y Harel; Fiscal Year: 2010..targeting the Nogo-NgR pathway show promise in the treatment of spinal cord injury and other central nervous system diseases. However, much remains unknown regarding Nogo's function in uninjured cells...
- Clavulanic acid: a potential abuse-deterrent and CNS-active therapeuticScott M Rawls; Fiscal Year: 2012..Utilization of this proven strategy here may identify a novel CNS-active therapeutic, in much the same way that valproic acid is used to manage prostate cancer and NSAIDs are used to manage Alzheimer's disease. ..
- In Vivo Neuronal Modulation via Engineered G Protein-Coupled ReceptorsSARAH CLAIRE ROGAN; Fiscal Year: 2012..manipulating neuronal GPCR signaling in vivo. Additionally, the particular signaling pathways this proposal will investigate could reveal critical information regarding the etiology and treatment of mental illness. ..
- A Robust, Automated, Flexible System for Mouse Behavioral InformaticsBARTON GARRETT SELBY; Fiscal Year: 2011..This proposal aims to develop a unique and powerful new technology for robust, automated, and comprehensive behavioral analysis of preclinical CNS disease models to facilitate discovery of new treatments for CNS diseases. ..
- Selection-driven plant metabolites for treatment of CNS diseasesJohn M Littleton; Fiscal Year: 2011..Its simplicity and rapidity suggests that it may compete with the existing synthetic chemistry approaches, and might even revitalize the use of plants as a source of medicines for CNS disease. ..
- In vitro tools for preclinical analysis of cognitive therapies for schizophreniaKRISTEN RICHARDSON; Fiscal Year: 2012....
- Exploring the Role of the Brain Transcriptome in Cognitive DeclinePhilip L De Jager; Fiscal Year: 2013..proven very effective in other human disorders have now begun to yield dividends in aging-related central nervous system diseases. The challenge is now turning to understanding the functional consequences within the brain of ..
- Brain-targeted nanomedicine via buccal administrationHu Yang; Fiscal Year: 2010..This project will also explore buccal administration for systemic delivery of the proposed nanomedicine to reduce treatment cost and societal burden, increase patient compliance as well as improve the quality of the overall treatment. ..
- Gaucher disease:Treatment of neurodegenerative diseaseDao Pan; Fiscal Year: 2013..The approaches developed in the studies have general and significant applicability to neurodegenerative diseases including other LSDs, and Parkinson and Alzheimer diseases. ..
- Role of System xc- in Addiction: Developing &Phenotyping a Slc7a11 knockout ratAron M Geurts; Fiscal Year: 2013....
- Elucidation of M5 Muscarinic Receptor Neurophysiology using Allosteric ModulatorsDaniel J Foster; Fiscal Year: 2013..These studies are important to both elucidate the physiological role of M5 as well as to validate the therapeutic potential of M5 modulation in multiple CNS diseases such as Parkinson's Disease, ADHD, and drug addiction. ..
- Localized immobilization of ephrin-B2 for neurite guidance in 3D cultureMichael J Moore; Fiscal Year: 2010..The use of functional biomaterials that are able to selectively guide growing axons may suggest new treatment strategies for optic nerve and other central nervous system disorders. ..
- CD200 as a monocyte/macrophage switch for brain repair after strokeKazuhide Hayakawa; Fiscal Year: 2013..I will learn the biomaterials and in vivo optical imaging tools from my mentor/consultants. My long term goal is to grow and build my independent lab based on the theme of manipulating inflammation for brain repair. ..
- DEVELOPMENT OF SYNAPTIC PATHWAYS IN RETINANing Tian; Fiscal Year: 2013....
- Complement protection and anaphylatoxins in neuroinflammationBrian Martin; Fiscal Year: 2009..This information will be critical for understanding how and when complement might be a candidate therapeutic target in CNS disease. ..
- Qualification of Novel Immune Markers in Human Serum of Patients with MSMichelle Sexton; Fiscal Year: 2010..This F32 will provide support for the training of a new investigator involved in research which will help the public and health professional understand more about mechanisms of action of a CAM therapy. ..
- Role of Brain Estradiol in the Treatment of Male Depression and AnxietyLaszlo Prokai; Fiscal Year: 2013....
- In Vivo Control and Functional Visualization of Stem Cell-Driven CNS RegenerationJin Hyung Lee; Fiscal Year: 2010..This project, upon its success, will provide direct and functional assessment capabilities for the regenerated nerve tissue in vivo. This in turn will provide key guidance for developing novel stem cell therapies for CNS diseases. ..
- Neuron Target Interaction - a Developmental Genetic StudyKarl Herrup; Fiscal Year: 2010....
- The role of chemoattractant receptors in central nervous system diseasesPablo Iribarren; Fiscal Year: 2012....
- 2010 Myelin Gordon Research ConferenceWendy B Macklin; Fiscal Year: 2010..This highlights the potential clinical implications for our investigations on myelination and remyelination. ..
- Design of Class-specific HDAC Imaging Probes for Positron Emission TomographyJacob M Hooker; Fiscal Year: 2013..The outcome of this research will be a new technology for imaging epigenetic processes in vivo that can be used in both preclinical research and human studies. ..
- New Electroanalytical Methods for Single-Cell ExocytosisBo Zhang; Fiscal Year: 2013..As such, a detailed understanding of single exocytotic events is needed for better treatments for central nervous system diseases. Electroanalytical methods have played vital roles in this bioanalytical task in the past three ..
- Novel rhoptry effector proteins in Toxoplasma host-pathogen interactionPETER JOHN BRADLEY; Fiscal Year: 2013..Together, these complementary approaches promise to reveal novel mechanistic insights into how Toxoplasma uses this unique set of effector proteins to modulate its mammalian host cell. ..
- Selection-driven plant metabolites for treatment of CNS diseasesJohn M Littleton; Fiscal Year: 2013..The ultimate aim is to commercialize the technology as a platform for discovering and producing novel plant-derived natural products targeted on specific human CNS proteins. ..
- 3D Structure of Membrane ProteinsMichael Radermacher; Fiscal Year: 2013..We will determine the 3D structure of Complex I in different catalytic states to obtain insights into the function of this highly complicated enzyme. 1 ..
- A Comprehensive Platform for Transporter Mediated Drug-Drug Interaction StudiesYong Huang; Fiscal Year: 2012....
- In Vitro Dynamics of Kinesin 1 and Myosin VIPaul R Selvin; Fiscal Year: 2012..Problems within the motors cause brain cancer, Alzheimer's disease, etc. We seek to understand the basic workings of kinesins and myosin VI, two important motors. ..
- T CELL RECOGNITION OF MYELIN IN MULTIPLE SCLEROSISDavid A Hafler; Fiscal Year: 2010....
- Development of small molecule Limk inhibitors for probing ocular diseasesPhilip LoGrasso; Fiscal Year: 2012..These compounds will serve as useful molecular tools to study the biological functions of Limk, and to probe ocular diseases and other Limk related CNS diseases. ) ..
- iPS Cell-Derived Neurons Carrying an allelic series of CNTNAP2 structural mutatioMARIA contact KARAYIORGOU; Fiscal Year: 2010..promise in generating induced pluripotent stem (iPS) cell lines from patients afflicted with central nervous system diseases, including psychiatric disorders...
- 2012 Myelin Gordon Research Conference &Gordon Research SeminarJames Salzer; Fiscal Year: 2012..In keeping with the goals of the Gordon Research Conference, such interactions will provide impetus and accelerate progress in the field of myelin biology. ..
- Post-translational Regulation of Opioid and Cannabinoid ReceptorsLakshmi A Devi; Fiscal Year: 2013....
- Novel PDE5 inhibitors as a therapeutic tool against Alzheimer's DiseaseOttavio Arancio; Fiscal Year: 2013..However, none of the existing inhibitors has been developed to counteract CNS diseases. We now propose to find phosphodiesterase 5 inhibitors that might be used in chronic CNS diseases such as Alzheimer's disease. ..
- Metabolomic Signatures and Biomarkers for SchizophreniaRIMA F KADDURAH-DAOUK; Fiscal Year: 2011..If we succeed in discovering a disease signature for schizophrenia, this could provide an external validating measure that will improve clinical and may offer leads to the underlying pathophysiology of schizophrenia. ..
- 2010 Barriers of the CNS Gordon Research ConferenceGert Fricker; Fiscal Year: 2010....
- Confocal Microscope for the Study of Neurologic DiseasesTracy L Young-Pearse; Fiscal Year: 2012....
- Heterologous expression of an invertebrate sodium channel for neuronal activationADAM RORY MCQUISTON; Fiscal Year: 2010..These studies will provide us with a model to understand the role of specific neurons in normal brain function and in psychiatric and neurological disorders. ..
- Functional Restoration of the Optic Nerve After Disease or DamageDong Feng Chen; Fiscal Year: 2010..The results of these proposed studies will open the door for future development of treatment strategies for optic nerve damage after disease or injury. ..
- Human Neurotropic JC Virus and CNS DiseasesKamel Khalili; Fiscal Year: 2006..abstract_text> ..
- SUBSTANCE P, NO & MICROGLIA IN CNS INFLAMMATIONBarnett Nathan; Fiscal Year: 2003..SP and NO modulate their effects in CNS inflammation via these cells. Hypothesis 4: The ultimate site for the effects of SP and NO may be the mitochondrial respiratory chain enzymes of these phagocytic cells. ..
- A Nonisotopic HTS Assay to Elucidate Choline Transporter (CHT) ModulatorsALICIA RUGGIERO; Fiscal Year: 2009....
- CATECHOLAMINES, ANTIOXIDANTS AND OXIDATIVE STRESSKandatege Wimalasena; Fiscal Year: 2003..The degneration of catecholaminergic neurons in aging and central nervous system diseases such as Parkinson's Disease, as well as in the use of illicit drugs such as amphetamines have been ..
- COST-EFFECTIVE MANAGEMENT OF HIV-RELATED ILLNESSESAnna Tosteson; Fiscal Year: 1991..Many HIV-related central nervous system diseases are potentially treatable, but rapidly fatal if undiagnosed...
- Force Plate Actometer for Measuring Behavior in RodentsCandice Kissinger; Fiscal Year: 2003..abstract_text> ..
- NEW CNS DOPAMINE RECEPTOR IMAGING AGENTSHANK KUNG; Fiscal Year: 2002....
- Improving the CNS Delivery of Anti-retroviral CompoundsWILLIAM ELMQUIST; Fiscal Year: 2007..New approaches to improve brain penetration of anti-HIV drugs will be valuable in the treatment of HIV-encephalopathy and in eradicating the virus from potential sanctuary sites. ..
- DRUG SELF ADMINISTRATION IN MOUSE MODELS OF NEUROAIDSLisa Gold; Fiscal Year: 1999....
- MOLEC PATHOPHYS OF CLIN VARIATION IN SPINAL CORD DISEASEEric Hoffman; Fiscal Year: 2001..Our findings should have significance for the progression of inherited forms of spastic paraplegia but also more broadly for spinal cord injury and CNS homeostasis. ..