shy drager syndrome
Summary: A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord, which differentiates this condition from other forms of idiopathic orthostatic hypotension (HYPOTENSION, ORTHOSTATIC). This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with orthostasis and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)
Publications114 found, 100 shown here
- Shy-Drager syndrome: multisystem atrophy with comorbid depressionJean Hemingway
Department of Psychiatry and Psychology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Psychosomatics 46:73-6. 2005
- The effects of water ingestion on orthostatic hypotension in two groups of chronic autonomic failure: multiple system atrophy and pure autonomic failureT M Young
Neurovascular Medicine Unit, Faculty of Medicine, Imperial College London at St Mary s Hospital, London, UK
J Neurol Neurosurg Psychiatry 75:1737-41. 2004....
- New findings on the neuropathology of multiple system atrophyEduardo E Benarroch
Neurophysiological Laboratory, Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Auton Neurosci 96:59-62. 2002....
- Deep brain stimulation improves orthostatic regulation of patients with Parkinson diseaseB Stemper
Department of Neurology, University of Erlangen Nuernberg, Germany
Neurology 67:1781-5. 2006..To evaluate whether subthalamic nucleus (STN) stimulation has an effect on the orthostatic regulation of patients with Parkinson disease (PD), we studied cardiovascular regulation during on and off phases of STN stimulation...
- Plasma levels of catechols and metanephrines in neurogenic orthostatic hypotensionD S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1620, USA
Neurology 60:1327-32. 2003..From the concept of a unitary sympathoadrenomedullary system, one might predict parallel sympathoneural and adrenomedullary abnormalities in NOH...
- Assessment of autonomic dysfunction of multiple system atrophy with laryngeal abductor paralysis as an early manifestationKazushi Deguchi
Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
Clin Neurol Neurosurg 109:892-5. 2007..Diagnosis of atypical MSA with LAP in the early stages might be accelerated by a detailed investigation focused on urinary symptoms and neuroendocrine approaches...
- [Blood pressure and heart rate regulation in diabetics]P Valensi
, , , avenue du 14-Juillet, 93143 Bondy
Arch Mal Coeur Vaiss 93:51-8. 2000....
- Recognizing and treating diabetic autonomic neuropathyA I Vinik
the Strelitz Diabetes Research Institutes, Department of Internal Medicine and Anatomy/Neurobiology, Eastern Virginia Medical School, Norfolk, USA
Cleve Clin J Med 68:928-30, 932, 934-44. 2001..Strict glycemic control can slow the onset of diabetic autonomic neuropathy and sometimes reverse it. Pharmacologic and nonpharmacologic therapies are available to treat symptoms...
- [Dopamine-beta-hydroxylase]Kazumasa Isobe
Graduate School of Comprehensive Human Science, Tsukuba University
Nihon Rinsho 63:391-4. 2005
- [Shy-Drager syndrome]Yukio Nakamura
Department of Cardiology, National Hospital Organization, Kanazawa Medical Center
Nippon Rinsho . 2007
- Catechol-o-methyltransferase and blood pressure in humansJens Jordan
Franz Volhard Clinical Research Center and Helios Klinikum Berlin, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
Circulation 106:460-5. 2002..Whether catechol-O-methyltransferase (COMT), the enzyme that metabolizes extraneuronal norepinephrine, contributes to blood pressure regulation in humans is unknown...
- Modulation of QT interval during autonomic nervous system blockade in humansAndre Diedrich
Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tenn 37232 2195, USA
Circulation 106:2238-43. 2002..We used the alternative approach of interrupting neurotransmission at the level of autonomic ganglia to determine its effect on the QT interval...
- Shy-Drager syndrome and severe unexplained intraoperative hypotension responsive to vasopressinRicardo Vallejo
Anesthesiology Department, Jackson Memorial Hospital University of Miami, Florida, USA
Anesth Analg 95:50-2, table of contents. 2002..We suggest that vasopressin may be the drug of choice in patients with Shy-Drager syndrome with refractory hypotension...
- Spatial patterns of alpha-synuclein positive glial cytoplasmic inclusions in multiple system atrophyRichard A Armstrong
Vision Sciences, Aston University, Birmingham, United Kingdom
Mov Disord 19:109-12. 2004..These spatial patterns contrast with those reported for filamentous neuronal inclusions in the tauopathies and alpha-synucleinopathies...
- Blood pressure recovery from Valsalva maneuver in patients with autonomic failureElizabeth R Vogel
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
Neurology 65:1533-7. 2005..Blood pressure (BP) changes in response to the Valsalva maneuver (VM) reflect the integrity of the baroreflex that regulates BP, and the phases of VM are widely used indices of adrenergic evaluation...
- Pyridostigmine treatment trial in neurogenic orthostatic hypotensionWolfgang Singer
Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Arch Neurol 63:513-8. 2006..By enhancing ganglionic transmission, pyridostigmine bromide can potentially ameliorate OH without worsening supine hypertension...
- Acute paraneoplastic dysautonomiaA Al-Shekhlee
Department of Neurology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106, USA
Eur Neurol 49:64-5. 2003
- Excessive nitric oxide function and blood pressure regulation in patients with autonomic failureAlfredo Gamboa
Department of Medicine, Vanderbilt University, Nashville, Tenn 37212, USA
Hypertension 51:1531-6. 2008..Potentiation of NO could be used in the treatment of supine hypertension, and its inhibition offers a novel approach to improve orthostatic hypotension...
- Treating blood pressure in familial dysautonomiaIrwin J Schatz
Clin Auton Res 15:249-50. 2005
- From orthostatic hypotension to Shy-Drager syndromeJ M S Pearce
J Neurol Neurosurg Psychiatry 75:1666. 2004
- Octreotide for orthostatic hypotensionM Lamarre-Cliche
Clinical Pharmacology, Centre Hospitalier de l Universite de Montreal CHUM, Canada
Can J Clin Pharmacol 6:213-5. 1999..It is a useful adjunct for the short term treatment of orthostatic hypotension associated with dysautonomia. Its long term efficacy and safety need to be studied...
- Chronic hypotension. In the shadow of hypertensionD Robertson
Department of Medicine, Vanderbilt University, Nashville, TN 37232-2195
Am J Hypertens 5:200S-205S. 1992..The differentiation of these and other causes of symptomatic hypotension may in many cases lead to beneficial therapy...
- [Central nervous system disorders]Ryuji Sakakibara
Department of Neurology, Chiba University School of Medicine
Nihon Rinsho 60:315-21. 2002
- Autonomic control after blockade of the norepinephrine transporter: a model of orthostatic intoleranceRobert P Carson
Autonomic Dysfunction Center, Vanderbilt University, Nashville, Tennessee 37232 2195, USA
J Appl Physiol 93:2192-8. 2002..Thus attenuated baroreflex function and reduced sympathetic outflow may contribute to the orthostatic intolerance of severe NET deficiency...
- Cardiac and extracardiac sympathetic denervation in Parkinson's disease with orthostatic hypotension and in pure autonomic failureDnyanesh N Tipre
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Nucl Med 46:1775-81. 2005..In this study, we examined whether 6-(18)F-fluorodopamine can visualize sympathetic innervation in extracardiac organs and, if so, whether patients with PD+OH or PAF have neuroimaging evidence of extracardiac noradrenergic denervation...
- [Morphological magnetic resonance imaging: its value for the diagnosis of neurodegenerative diseases]U Hahn
Praxis für Radiologische Diagnostik und Nuklearmedizin, Stuttgart Bad Cannstatt
Dtsch Med Wochenschr 133:S15-8. 2008..MRI is of minor importance for differentiating Alzheimer's disease from frontotemporal dementia or dementia with Lewy bodies. However, specific patterns are found in cerebral amyloid angiopathy and prion diseases....
- Cardiac response rate variability in physically abused women of childbearing ageMichael J Rice
Washington State University, Intercollegiate College of Nursing, 2917 W Ft Wright Drive, Spokane, WA 99224, USA
Biol Res Nurs 7:204-13. 2006..These findings support further testing with larger samples to identify vasovagal changes in abused pregnant women...
- [Autonomic dysfunction and orthostatic intolerance. Cardiologic diagnosis and treatment options]Thomas Klingenheben
Praxis für Kardiologie, Bonn
Med Klin (Munich) 101:76-9. 2006..definition of these disorders has changed significantly. This review summarizes the current knowledge of diagnosis and treatment of the syndromes of orthostatic intolerance...
- Changes in cerebral oxygenation and haemodynamics during postural blood pressure changes in patients with autonomic failureKatharine Hunt
Department of Neuroanaesthesia and Neurocritical Care, The National Hospital for Neurology and Neurosurgery and Institute of Neurology, Queen Square, London WC1N 3BG, UK Centre for Anaesthesia, University College London, UK
Physiol Meas 27:777-85. 2006..Postural hypotension in patients with autonomic failure is associated with a substantial decrease in absolute cerebral oxygenation measured by NIRS and this might reflect a critical reduction in cerebral oxygen delivery...
- Functional neuroimaging of sympathetic innervation of the heartDavid S Goldstein
Building 10, Room 6N252, NINDS, NIH, 10 Center Drive, MSC 1620, Bethesda, MD 20892 1620, USA
Ann N Y Acad Sci 1018:231-43. 2004..Analogous abnormalities might help explain increased cardiovascular risk in psychiatric disorders such as melancholic depression...
- Drug treatment of orthostatic hypotension because of autonomic failure or neurocardiogenic syncopeMaxime Lamarre-Cliche
Hôpital Européen Georges Pompidou Centre d Investigations Cliniques, Paris, France
Am J Cardiovasc Drugs 2:23-35. 2002..Little is known about the effectiveness and tolerability of specific combinations of pressor drugs. Consequently, sound clinical judgment and close follow-up of patients should always guide combination therapy...
- Orthostatic hypotension and attention in Parkinson's disease with and without dementiaC Peralta
Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
J Neural Transm 114:585-8. 2007..828, P < 0.05; DeltaDBP and TEA-2, r = 0.828, P < 0.05). We conclude that OH is frequent in PDD and should be addressed therapeutically since it may exacerbate attentional dysfunction...
- Pupil findings in a consecutive series of 150 patients with generalised autonomic neuropathyF Bremner
Department of Neuro Ophthalmology, internal box 142, National Hospital for Neurology and Neurosurgery, Queen Square, PO Box 142, London WC1N 3BG, UK
J Neurol Neurosurg Psychiatry 77:1163-8. 2006..To detect and characterise the pattern and extent of pupil abnormalities in patients with generalised autonomic failure...
- Clinical effects of elastic bandage on neurogenic orthostatic hypotensionY Hasegawa
Dept of Neurology, Nagoya City Higashi General Hospital, Nagoya, Japan
J Gravit Physiol 7:P159-60. 2000..We investigated short-term clinical effects of commercially available EB on OH, and estimated the mechanism of its effectiveness by measuring some blood pressure-related humoral variables in neurodegenerative patients with OH...
- Ambulatory blood pressure variations relative to sitting or standing position in renal transplant patientsJean Phillippe Baguet
Department of Cardiology and Hypertension bDepartment of Nephrology, Grenoble University Hospital, Grenoble, France
Blood Press Monit 10:93-6. 2005..The main objective of this study was to analyse the variations in blood pressure and heart rate recorded by ambulatory measurement during changes in position in renal transplant patients...
- The nature of the autonomic dysfunction in multiple system atrophySamir M Parikh
Autonomic Dysfunction Center, Department of Medicine, Vanderbilt University, AA 3228 MCN, Nashville, TN 37232 2195, USA
J Neurol Sci 200:1-10. 2002..We will review recent evidence bearing on autonomic tone in MSA and discuss their therapeutic implications, particularly in terms of the possible development of a bionic baroreflex for better control of blood pressure...
- Multiple system atrophy: alpha-synuclein and neuronal degenerationMari Yoshida
Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Aichi, Japan
Neuropathology 27:484-93. 2007..The oligo-myelin-axon-neuron complex mechanism, along with the direct involvement of neurons themselves, may synergistically accelerate the degenerative process of MSA...
- Familial mydriasis, cardiac arrhythmia, respiratory failure, muscular weakness and hypohidrosisO Sjaastad
Department of Neurology and the Laboratory for the study of autonomic disorders, Trondheim University Hospital, Norway
Acta Neurol Scand Suppl 174:3-31. 2000..The main features were: mydriasis, cardiac arrhythmia, cardiomegaly, hypohidrosis, respiratory failure, and muscular weakness...
- [Syndromes of autonomic insufficiency associated with orthostatic intolerance: classification, diagnostic and therapeutic approach]B P Grubb
Medical College of Ohio, Dept of Medicine, Div of Cardiology, Richard D Ruppert Health Center, Toledo 43614 5809, USA
Z Kardiol 88:541-9. 1999..This review summarizes the current knowledge of autonomic disorders, their classification and diagnostic and therapy strategies...
- [General anesthesia in a patient with idiopathic orthostatic hypotension]I Ionescu
Zentrum für Anästhesiologie und Intensivmedizin, Klinik fur Anasthesiologie, Universitatsklinikum Hamburg Eppendorf, Deutschland
Anaesthesist 59:140-3. 2010..In the case presented perioperative hemodynamic stability was achieved by aggressive volume therapy guided by global end-diastolic volume measurement and low-dose catecholamine therapy...
- Intrathecal baclofen for autonomic instability due to spinal cord injuryMarkus Kofler
Department of Neurology, Hospital Hochzirl, Austria
Auton Neurosci 146:106-10. 2009..This case demonstrates that ITB administration may help to stabilize autonomic dysreflexia and orthostatic hypotension in patients with spinal cord lesions...
- Apolipoprotein E e4 allele frequency in patients with multiple system atrophyN J Cairns
Brain Bank, Department of Neuropathology, Institute of Psychiatry, London, UK
Neurosci Lett 221:161-4. 1997..The APOE e4 allele frequency of the MSA cases (0.11) was not significantly different from that of the control subjects (0.12). These data indicate that the APOE e4 allele is not a risk factor for multiple system atrophy...
- [Historical overview of REM sleep behavior disorder in relation to its pathophysiology]Naoko Tachibana
Department of Neurology and Center for Sleep related Disorders, Kansai Electric Power Hospital, 2 1 7 Fukushima, Fukushima ku, Osaka 553 0003, Japan
Brain Nerve 61:558-68. 2009..RBD is not a homogeneous clinical entity, and further refinement of its diagnostic classification is warranted to avoid diagnostic confusion...
- [Development of L-threo-DOPS, a norepinephrine precursor amino acid]J Katsube
Sumitomo Pharmaceuticals Co, Ltd, Osaka, Japan
Yakugaku Zasshi 114:823-46. 1994..The R & D of L-DOPS described in this paper includes studies on industrial production, efficacy pharmacology (mode of action), metabolism and clinical trial of this agent...
- Determination of D,L-threo-3,4-dihydroxyphenylserine and of the D- and L-enantiomers in human plasma and urineF Boomsma
Department of Internal Medicine I, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands
J Chromatogr 427:219-27. 1988..28; r = 0.997; n = 52). Excellent agreement was found between the sum of the D- and L-DOPS concentrations and the measured total D,L-DOPS concentration (regression line DOPS (D + L) = 0.955 DOPS (total, LE) + 116.65; r = 0.992; n = 100)...
- Orthostatic intolerance and the postural tachycardia syndrome: genetic and environment pathophysiologies. Neurolab Autonomic TeamD Robertson
Center for Space Physiology and Medicine, Clinical Research Center, Vanderbilt University, Nashville, TN 37232 2195, USA
Pflugers Arch 441:R48-51. 2000..This leads to poor clearance of norepinephrine from synapses, with consequent raised heart rate. Clinical features of these syndromes are presented...
- Orthostatic intolerance in pediatricsJulian M Stewart
Department of Pediatrics and Physiology, The Center for Pediatric Hypotension, New York Medical College, Valhalla 10595, USA
J Pediatr 140:404-11. 2002
- [Anesthesia for emergency surgery in a patient with Shy-Drager syndrome]H Hashimoto
Department of Anesthesiology, University of Tokyo, Faculty of Medicine, Tokyo 113-8655
Masui 50:40-1. 2001..He was extubated on the first postoperative day without any complications. The effects of vecuronium, norepinephrine, and dopamine might be changed in the patient with Shy-Drager syndrome...
- Dysautonomia and cognitive dysfunction in Parkinson's diseaseWerner Poewe
Department of Neurology, Medical University Innsbruck, Innsbruck, Austria
Mov Disord 22:S374-8. 2007..This raises the possibility that spread of synuclein pathology to involve neocortical areas producing cognitive decline could be somehow linked to involvement of the autonomic nervous system in PD...
- New squatting test indices are useful for assessing baroreflex sensitivity in diabetes mellitusM Nakagawa
Department of Cardiovascular Science, Division of Laboratory Medicine, Oita University School of Medicine, Oita, Japan
Diabet Med 25:1309-15. 2008..Our aim was to develop new simple squatting test indices and to analyse their applicability to the assessment of baroreflex sensitivity (BRS) in patients with diabetes...
- Characteristic MRI findings in multiple system atrophy: comparison of the three subtypesH Naka
Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan
Neuroradiology 44:204-9. 2002..Our findings suggest that, although MSA can be divided clinically into three subtypes, most of the features on MRI are common and overlap in the subtypes, independently of the clinical presentation...
- [A case of pure autonomic failure (PAF) with sleep apnea syndrome (SAS) and successful treatment of dysautonomia with nasal continuous positive airway pressure (CPAP)]Eri Hamada
Department of Neurology, Ehime Prefectural Central Hospital
Nihon Ronen Igakkai Zasshi 41:233-6. 2004..This case raised the possibility that nasal CPAP may be useful for orthostatic hypotension as well as SAS in neurodegenerative diseases...
- [MSA update]Shoji Tsuji
Department of Neurology, Graduate School of Medicine, University of Tokyo
Rinsho Shinkeigaku 45:821-3. 2005..Integrated analyses of non-parametric linkage analyses on the familial MSA cases and association studies on sporadic MSA cases are expected to accelerate the studies on identification of genes involved in the pathogenesis of MSA...
- Autonomic nervous system function in chronic dizzinessJeffrey P Staab
Department of Psychiatry, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
Otol Neurotol 28:854-9. 2007....
- [Mechanism of neuronal degeneration of multiple system atrophy]Mari Yoshida
Institute for Medical Science of Aging, Aichi Medical University, 21 Karimata, Yazako, Nagakute cho, Aichi Gun, Aichi 480 1195
Brain Nerve 61:1051-60. 2009..Therefore, both the direct involvement of neurons themselves and the oligodendroglia-myelin-axon mechanism may synergistically accelerate the degenerative process of MSA...
- Excessive daytime sleepiness and unintended sleep in Parkinson's diseaseDavid B Rye
Department of Neurology, Emory University School of Medicine, 101 Woodruff Circle, WMRB Suite 6000, PO Drawer V, Atlanta, GA 30322, USA
Curr Neurol Neurosci Rep 6:169-76. 2006..Sleepiness in parkinsonism, especially a narcolepsy-like phenotype, may necessitate treatment with wake-promoting agents such as bupropion, modafinil, or traditional psychostimulants...
- Are the orthostatic fluid shifts to the calves augmented in autonomic failure?Roland D Thijs
Department of Neurology and Clinical Neurophysiology, Leiden University Medical Centre, Postal Zone J3 R, PO Box 9600, 2300 RC, Leiden, The Netherlands
Clin Auton Res 20:19-25. 2010..In autonomic failure (AF), blood pressure (BP) falls upon standing which is commonly ascribed to defective vasoconstriction and excessive pooling. Observations on the amount of pooling in AF are contradictory...
- Chiari drop attacks: surgical decompression and the role of tilt table testingDavid Straus
Pritzker School of Medicine, Chicago, IL, USA
Pediatr Neurosurg 45:384-9. 2009..It has been postulated that Chiari drop attack is secondary to dysautonomia caused by hindbrain compression. There has been recent debate regarding the association between CM1, dysautonomia and Chiari drop attack...
- Cerebral vasomotor reactivity in Parkinson's disease, multiple system atrophy and pure autonomic failureTanya Gurevich
Neurology Department, Tel Aviv Medical Center, Israel Sieratzki Chair of Neurology, Tel Aviv University, Israel
J Neurol Sci 243:57-60. 2006..We conclude that BFV is normal in PD, MSA and PAF and that the VMR, as investigated by TCD and the Diamox test, did not disclose differences in cerebral vasomotor responses between these conditions...
- Dopamine agonist withdrawal syndrome in Parkinson diseaseChristina A Rabinak
Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York 10021, USA
Arch Neurol 67:58-63. 2010..To report and characterize a dopamine agonist (DA) withdrawal syndrome (DAWS) in Parkinson disease...
- Red flags for multiple system atrophyMartin Köllensperger
Section for Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Austria
Mov Disord 23:1093-9. 2008..9 (+/-7.0) months earlier than with the Consensus criteria alone. We propose a combination of two out of six red flag categories as additional diagnostic criteria for probable MSA-P...
- [Orthostatic hypotension]Yukio Nakamura
Department of Cardiology, National Hospital Organization, Kanazawa Medical Center
Nippon Rinsho . 2007
- Neuropharmacologic distinction of neurogenic orthostatic hypotension syndromesYehonatan Sharabi
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620, USA
Clin Neuropharmacol 29:97-105. 2006....
- Recent developments in multiple system atrophyGregor K Wenning
Section of Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
J Neurol 256:1791-808. 2009..An outline of the rationale for managing symptomatic deterioration in MSA is provided together with a summary of novel experimental therapeutic approaches to decrease disease progression...
- Effects of daily water drinking on orthostatic and postprandial hypotension in patients with multiple system atrophyKazushi Deguchi
Dept of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Kita gun, Kagawa, 761 0793, Japan
J Neurol 254:735-40. 2007..The aim of this study was to evaluate the practical effect of daily water drinking on OH and PPH in the morning when patients with AF are usually most affected...
- Other autonomic neuropathies associated with ganglionic antibodyPaola Sandroni
Mayo Clinic, Department of Neurology, 200 First Street SW, Rochester, MN 55905, USA
Auton Neurosci 146:13-7. 2009..Other antigens and antibodies yet to be identified are more likely to be responsible in these disorders...
- Is cerebral autoregulation impaired in Parkinson's disease? A transcranial Doppler studyN Vokatch
Department of Neurology, Geneva University Hospitals and Medical School, Switzerland
J Neurol Sci 254:49-53. 2007..These results provide evidence of an impaired cerebral autoregulation in PD patients which appears independent of dopaminergic treatment...
- Normal cardiovascular reflex testing in patients with parkin diseaseFrancesca Del Sorbo
Istituto Neurologico Carlo Besta, Milano, Italy
Mov Disord 22:528-32. 2007..Urinary dysautonomia warrants further investigation in patients with parkin disease...
- Autoimmune autonomic ganglionopathy with Sjögren's syndrome: significance of ganglionic acetylcholine receptor antibody and therapeutic approachTakayuki Kondo
Department of Neurology, Kyoto University Hospital, Kyoto, Japan
Auton Neurosci 146:33-5. 2009..These two cases indicate that chronic AAG may be treatable by immunomodulatory therapy, and have relevance to SS...
- Clinical laboratory evaluation of autoimmune autonomic ganglionopathy: Preliminary observationsDavid S Goldstein
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 1620, USA
Auton Neurosci 146:18-21. 2009..PAF entails cardiac sympathetic denervation, whereas cardiac sympathetic neuroimaging by thoracic 6-[(18)F]fluorodopamine scanning indicates intact myocardial sympathetic innervation in AAG...
- Postural tachycardia syndromeBlair P Grubb
Department of Medicine, University of Toledo, 3000 Arlington Ave, Toledo, Ohio 43614, USA
Circulation 117:2814-7. 2008
- RNA sequestration to pathological lesions of neurodegenerative diseasesS D Ginsberg
Center for Neurodegenerative Disease Research and Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
Acta Neuropathol 96:487-94. 1998..These observations demonstrate the selective localization of RNA species to distinct pathological lesions of neurodegenerative disease brains...
- Evaluation and management of autonomic nervous system disordersCaroline M Klein
Department of Neurology, The University of North Carolina School of Medicine, 3114 Bioinformatics, Campus Box 7025, Chapel Hill, NC 27599 7025, USA
Semin Neurol 28:195-204. 2008..These advances include testing for ganglionic acetylcholine receptor antibody in patients with suspected autoimmune autonomic neuropathy and use of pyridostigmine for treatment of patients with orthostatic hypotension or tachycardia...
- Quantitative autonomic testing in the management of botulismRaffi Topakian
Department of Neurology, Academic Teaching Hospital Wagner Jauregg, Wagner Jauregg Weg 15, Linz 4020, Austria
J Neurol 256:803-9. 2009..QAT identified autonomic involvement in botulism patients with otherwise benign neurological presentation. Comprehensive evaluation of autonomic failure may provide useful information for the management of botulism...
- Aging of complex heart rate dynamicsZbigniew R Struzik
Educational Physiology Laboratory, Graduate School of Education, The University of Tokyo, Japan
IEEE Trans Biomed Eng 53:89-94. 2006..Based upon this, we propose a novel picture of "autonomic aging," characterized by an insufficiency of the SNS function to cope dynamically with various environmental stimuli...
- Case report: Marathon runner with severe autonomic failureEmily M Garland
Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN 37232, USA
Lancet 366:S13. 2005
- Unusual causes of severe orthostatic hypotensionM Abu Nasar
Hosp Med 63:240-1. 2002
- Diagnosis and treatment of supine hypertension in autonomic failure patients with orthostatic hypotensionJens Jordan
Hypotension and Syncope Unit, Clinical Research Center, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University, Berlin, Germany
J Clin Hypertens (Greenwich) 4:139-45. 2002..During the day, avoiding the supine position is often all that is required. Short-acting vasodilators (e.g., transdermal nitroglycerin) can be used during the night...
- [A case of "pure" progressive autonomic failure in an elderly male]T Kuwahara
Second Department of Internal Medicine, Ehime University School of Medicine
Nihon Ronen Igakkai Zasshi 29:790-3. 1992..It shows symptoms of autonomic failure without other neurological disturbances which manifest as Shy-Drager syndrome. Treatment with L-DOPS increased his blood pressure level and attenuated his symptoms due to orthostatic hypotension...
- Neurodegeneration, parkinsonian syndromes and autonomic failureChristopher J Mathias
University Department of Clinical Neurology, National Hospital for Neurology, University College London, UK
Auton Neurosci 96:50-8. 2002
- [Dysautonomic features in patients with Cuban type 2 spinocerebellar ataxia]G Sánchez-Cruz
Clínica Cubana para la Investigación y Rehabilitación de las Ataxias Hereditarias CIRAH, Holguin, Cuba
Rev Neurol 33:428-34. 2001..Dysautonomic features are the clinical signs and symptoms derived from anomalous functioning of the sympathetic or parasympathetic nervous systems in either the peripheral or central parts...
- [Autonomic dysfunction with nocturnal dyspnea (Gerhardt-syndrome) in a patient with multiple system atrophy]M Eissler
Med Klin (Munich) 96:626-31. 2001..TREATMENT AND COURSE: The patient needed a tracheotomy and treatment of the autonomic symptoms. He could be discharged in better psychic condition, without syncopes or respiratory problems...
- Autonomic failure after stroke--is it indicative for pathophysiology of complex regional pain syndrome?B Riedl
Neurologische Klink, Friedrich Alexander Universitat, Erlangen, Germany
Acta Neurol Scand 103:27-34. 2001..In conclusion, our investigation suggests that many clinical symptoms and the main features of sympathetic dysfunction in CRPS could be explained by a CNS pathophysiology...
- Overexpression of the alpha1B-adrenergic receptor causes apoptotic neurodegeneration: multiple system atrophyM J Zuscik
Department of Molecular Cardiology NB50, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
Nat Med 6:1388-94. 2000..Our results indicate that overstimulation of alpha1BAR leads to apoptotic neurodegeneration with a corresponding multiple system atrophy indicative of Shy-Drager syndrome, a disease whose etiology is unknown...
- Diurnal blood pressure variation in progressive autonomic failureM J Carvalho
Centro de Estudos de Função Autonomica, Hospital S Joao, Oporto Medical School, Oporto, Portugal
Hypertension 35:892-7. 2000..For the maintenance of a normal circadian BP pattern, not only an intact sympathetic but also an intact afferent parasympathetic ANS is a prerequisite...
- Visceral orthostatic hypotension in patients with severe autonomic dysfunctionH Terazaki
First Department of Internal Medicine, Kumamoto University School of Medicine, Honjo, Japan
J Auton Nerv Syst 68:101-8. 1998..These results suggest that FAP is a disease for which this kind of ultrasonographic examination should be applied, and that Doppler ultrasonography may be a helpful tool to evaluate visceral OH...
- Autoimmune autonomic failure in a patient with myeloma-associated Shy-Drager syndromeD S Goldstein
Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA
Clin Auton Res 6:17-21. 1996..Since in this case the monoclonal antibody produced by the myeloma bound specifically to LC cells, the results are consistent with the hypothesis that in this patient the Shy-Drager syndrome may have had an immune-mediated basis...
- Electro-oculogram in multiple system and late onset cerebellar atrophiesJ Arpa
Servicio de Neurologia, Hospital La Paz, Madrid
Rev Neurol 23:969-74. 1995..05) and SND subjects (p < 0.01). SDS also showed abnormalities of the oculomotor system...
- High beta-adrenoceptor density on peripheral blood mononuclear cells in progressive multiple sclerosis: a manifestation of autonomic dysfunction?Y Zoukos
Multiple Sclerosis Laboratory, National Hospital for Neurology and Neurosurgery, London, England
Acta Neurol Scand 90:382-7. 1994....
- Effect of L-threo-3,4-dihydroxyphenylserine on muscle sympathetic nerve activities in Shy-Drager syndromeT Kachi
Department of Neurology, National Chubu Hospital, Obu, Japan
Neurology 38:1091-4. 1988..We suggest that the OH improved mainly because of the increase in MSA due to L-threo-DOPS, and that the drug may activate sympathetic outflow at a site proximal to the sympathetic ganglion...
- Beta-adrenergic blood pressure regulation in Shy-Drager syndrome and pheochromocytomaM Middeke
Medizinische Poliklinik, Ludwig Maximilians Universitt, Munchen
Klin Wochenschr 67:1004-9. 1989..The findings in pheochromocytoma add support to the theory that an acute catecholamine stimulation gives rise to an acute beta-adrenergic sensitization leading to blood pressure elevation.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Shy-Drager syndrome. Effect of fludrocortisone and L-threo-3,4-dihydroxyphenylserine on the blood pressure and regional cerebral blood flowS Matsubara
Department of Neurology, Kanazawa University School of Medicine, Japan
J Neurol Neurosurg Psychiatry 53:994-7. 1990..Fludrocortisone reduced the fall of the mean blood pressure significantly. DOPS reduced the fall of both the diastolic blood pressure and rCBF significantly...
- Xamoterol in the treatment of orthostatic hypotension associated with multiple system atrophy (Shy-Drager syndrome)J N West
University of Birmingham Department of Cardiovascular Medicine, East Birmingham Hospital
Q J Med 74:209-13. 1990..Intravenous test doses of xamoterol did not predict either the attenuation of orthostatic hypotension or the development of supine hypertension in all patients...
- Postural variation in intraocular pressure in primary chronic autonomic failureMartin J Dumskyj
Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George s Hospital Medical School, Cranmer Terrace, London, UK, SW17 ORE
J Neurol 249:712-8. 2002..These data show that patients with autonomic failure are subject to large posture-related changes in IOP. These appear to be related to the large posture-induced changes in systemic blood pressure which occur in these patients...
- Hypertension in orthostatic hypotension and autonomic dysfunctionItalo Biaggioni
Departments of Medicine and Pharmacology, Division of Clinical Pharmacology, 1500 21st Avenue South, Suite 3500, Vanderbilt University, Nashville, TN 37212, USA
Cardiol Clin 20:291-301, vii. 2002..Supine hypertension complicates the treatment of these patients but can be managed by overnight administration of antihypertensive medications...
- Helicobacter pylori infection and gastric function in primary autonomic neuropathySimona Maule
U O A D U Medicina 4, Ospedale San Vito, Torino, Italy
Clin Auton Res 12:193-6. 2002..Hp detection might be important for the gastrointestinal and extradigestive complications of such infection...
- Duplication of distal part of the basilar arteryMasanori Tsutsumi
Department of Neurosurgery, Fukuoka University Chikushi Hospital, Chikushino City, Japan
Radiat Med 20:265-7. 2002..We report a case of duplication or fenestration of the distal part of the basilar artery with Shy-Drager syndrome. Duplication and fenestration of the basilar artery are discussed, and a review of embryologic development is presented...
- [Dopamine]Ryoji Ozono
Department of Clinical Laboratory Medicine, Hiroshima University Graduate School of Biomedical Sciences
Nihon Rinsho 63:388-90. 2005
- The Lewis family revisited: no evidence for autosomal dominant multiple system atrophyJose Berciano
Department of Neurology, University Hospital Marqués de Valdecilla UC, Santander, Spain
Parkinsonism Relat Disord 11:363-5. 2005..There remains no conclusive evidence to support the notion of hereditary MSA...
- [A patient with Shy-Drager syndrome managed under general anesthesia with thoracic epidural anesthesia]Kenji Shigematsu
Department of Anesthesiology, Fukuoka University School of Medicine, Fukuoka
Masui 54:788-90. 2005..It did not increase as expected with intravenous ephedrine. Intravenous etilefrine promptly raised the blood pressure. There was no postoperative cardiorespiratory complications...
- The PINK1 phenotype can be indistinguishable from idiopathic Parkinson diseaseA Albanese
National Neurologic Institute Carlo Besta, Universita Cattolica del Sacro Cuore, Milan, Italy
Neurology 64:1958-60. 2005....
- Bionic Baroreflex System for Blood Pressure ControlAndre Diedrich; Fiscal Year: 2002..A Phase II study would involve studies in animals and in patients with MSA to determine the long-term efficacy of the bionic baroreflex system in improving blood pressure control...
- BRAINSTEM SUBSTRATES OF DOPAMINE MODULATED MOVEMENTSDavid Rye; Fiscal Year: 2002..g., OCD, ADD, Tourette's and schizophrenia, the results will also bear relevance to a wider spectrum of disease. ..
- SLEEP/DOPAMINE PHENOTYPES IN GENETICALLY DISTINCT MICEDavid Rye; Fiscal Year: 2002..abstract_text> ..
- Circuitry of Midbrain Dopamine in Sleep & WakeDavid Rye; Fiscal Year: 2005..g., schizophrenia) and hypodopaminergic (e.g., PD and restless legs/periodic leg movements of sleep). ..