reflex sympathetic dystrophy

Summary

Summary: A syndrome characterized by severe burning pain in an extremity accompanied by sudomotor, vasomotor, and trophic changes in bone without an associated specific nerve injury. This condition is most often precipitated by trauma to soft tissue or nerve complexes. The skin over the affected region is usually erythematous and demonstrates hypersensitivity to tactile stimuli and erythema. (Adams et al., Principles of Neurology, 6th ed, p1360; Pain 1995 Oct;63(1):127-33)

Top Publications

  1. ncbi A controlled pilot study of the utility of mirror visual feedback in the treatment of complex regional pain syndrome (type 1)
    C S McCabe
    The Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, Bath BA1 1RL, UK
    Rheumatology (Oxford) 42:97-101. 2003
  2. ncbi Bilateral motor cortex disinhibition in complex regional pain syndrome (CRPS) type I of the hand
    P Schwenkreis
    Department of Neurology, Ruhr University Bochum, BG Kliniken Bergmannsheil, Bochum, Germany
    Neurology 61:515-9. 2003
  3. pmc Multiplex bead array assay for detection of 25 soluble cytokines in blister fluid of patients with complex regional pain syndrome type 1
    Claudia Heijmans-Antonissen
    Department of Anaesthesiology, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Mediators Inflamm 2006:28398. 2006
  4. pmc Systemic inflammatory mediators in post-traumatic complex regional pain syndrome (CRPS I) - longitudinal investigations and differences to control groups
    Christian Schinkel
    Berufsgenossenschaftliche Kliniken Bergmannsheil, Department of Surgery, Ruhr University, Bochum, Germany
    Eur J Med Res 14:130-5. 2009
  5. ncbi Biopsychosocial complexity is correlated with psychiatric comorbidity but not with perceived pain in complex regional pain syndrome type 1 (algodystrophy) of the knee
    Aurélie Vouilloz
    Clinique Romande de Réadaptation SuvaCare, avenue Grand Champsec 90, 1951 Sion, Switzerland
    Joint Bone Spine 78:194-9. 2011
  6. ncbi The effect of tactile discrimination training is enhanced when patients watch the reflected image of their unaffected limb during training
    G Lorimer Moseley
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Pain 144:314-9. 2009
  7. ncbi Is reflex sympathetic dystrophy/complex regional pain syndrome type I a small-fiber neuropathy?
    Anne Louise Oaklander
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 65:629-38. 2009
  8. ncbi Spinal cord stimulation in patients with chronic reflex sympathetic dystrophy
    M A Kemler
    Department of Surgery, Maastricht University Hospital, The Netherlands
    N Engl J Med 343:618-24. 2000
  9. ncbi Mast cells are involved in inflammatory reactions during Complex Regional Pain Syndrome type 1
    Frank J P M Huygen
    Pain Treatment Center, Department of Anaesthesiology, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Immunol Lett 91:147-54. 2004
  10. ncbi Inflammatory mediators are altered in the acute phase of posttraumatic complex regional pain syndrome
    Christian Schinkel
    Department of Surgery, Ruhr University, Bochum, Germany
    Clin J Pain 22:235-9. 2006

Research Grants

  1. Opioid Efficacy In Humans: A Twin Study
    DAVID J contact CLARK; Fiscal Year: 2010
  2. Inflammasome Activation in Complex Regional Pain Syndrome
    Wade S Kingery; Fiscal Year: 2013
  3. MECHANISM OF NOCICEPTION INDUCED BY INNOCUOUS COLD IN TRIGEMINAL SYSTEM
    Jianguo Gu; Fiscal Year: 2012
  4. POSTMORTEM STUDIES OF PAINFUL PERIPHERAL NEUROPATHY
    VIRGINIA SEYBOLD; Fiscal Year: 1991
  5. SYMPATHETIC EFFERENT MODULATION OF PAIN
    William Roberts; Fiscal Year: 1993
  6. Neurite density in skin as a marker for neuropathic pain
    Anne Louise Oaklander; Fiscal Year: 2005
  7. Mentored Patient-Oriented Research Career Development Aw
    Paola Sandroni; Fiscal Year: 2004
  8. The Roles of Heme Oxygenase in Pain
    David Clark; Fiscal Year: 2005
  9. Genetics of Opioid Induced Hyperalgesia
    David Clark; Fiscal Year: 2004
  10. MECHANISMS FOR TOLERANCE TO ACTIONS OF A2 AGONISTS
    David Clark; Fiscal Year: 2002

Detail Information

Publications229 found, 100 shown here

  1. ncbi A controlled pilot study of the utility of mirror visual feedback in the treatment of complex regional pain syndrome (type 1)
    C S McCabe
    The Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, Bath BA1 1RL, UK
    Rheumatology (Oxford) 42:97-101. 2003
    ..We assessed mirror visual feedback (MVF) to test the hypothesis that incongruence between motor output and sensory input produces complex regional pain syndrome (CRPS) (type 1) pain...
  2. ncbi Bilateral motor cortex disinhibition in complex regional pain syndrome (CRPS) type I of the hand
    P Schwenkreis
    Department of Neurology, Ruhr University Bochum, BG Kliniken Bergmannsheil, Bochum, Germany
    Neurology 61:515-9. 2003
    ..Its features include pain, edema, autonomic dysfunction, movement disorder, and trophic changes. CNS involvement is suggested by the symptoms, but the pathophysiology of CRPS I is unknown...
  3. pmc Multiplex bead array assay for detection of 25 soluble cytokines in blister fluid of patients with complex regional pain syndrome type 1
    Claudia Heijmans-Antonissen
    Department of Anaesthesiology, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Mediators Inflamm 2006:28398. 2006
    ..Ten representative cytokines were detectable. However, detection levels and amounts measured are at least 3 times higher in the multiplex-25 array assay than in the ELISA assays used simultaneously for the measurement of cytokines...
  4. pmc Systemic inflammatory mediators in post-traumatic complex regional pain syndrome (CRPS I) - longitudinal investigations and differences to control groups
    Christian Schinkel
    Berufsgenossenschaftliche Kliniken Bergmannsheil, Department of Surgery, Ruhr University, Bochum, Germany
    Eur J Med Res 14:130-5. 2009
    ..Some studies investigated the role inflammatory mediators and cytokines; however, few longitudinal studies exist and control groups except healthy controls were not investigated yet...
  5. ncbi Biopsychosocial complexity is correlated with psychiatric comorbidity but not with perceived pain in complex regional pain syndrome type 1 (algodystrophy) of the knee
    Aurélie Vouilloz
    Clinique Romande de Réadaptation SuvaCare, avenue Grand Champsec 90, 1951 Sion, Switzerland
    Joint Bone Spine 78:194-9. 2011
    ..characteristics of patients suffering from complex regional pain syndrome type 1 ([CRPS], also known as reflex sympathetic dystrophy or algodystrophy) of the knee with those of a matched group of patients experiencing post-traumatic ..
  6. ncbi The effect of tactile discrimination training is enhanced when patients watch the reflected image of their unaffected limb during training
    G Lorimer Moseley
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Pain 144:314-9. 2009
    ....
  7. ncbi Is reflex sympathetic dystrophy/complex regional pain syndrome type I a small-fiber neuropathy?
    Anne Louise Oaklander
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 65:629-38. 2009
    ..This was labeled reflex sympathetic dystrophy (RSD; now complex regional pain syndrome type I [CRPS-I])...
  8. ncbi Spinal cord stimulation in patients with chronic reflex sympathetic dystrophy
    M A Kemler
    Department of Surgery, Maastricht University Hospital, The Netherlands
    N Engl J Med 343:618-24. 2000
    Chronic reflex sympathetic dystrophy (also called the complex regional pain syndrome) is a painful, disabling disorder for which there is no proven treatment...
  9. ncbi Mast cells are involved in inflammatory reactions during Complex Regional Pain Syndrome type 1
    Frank J P M Huygen
    Pain Treatment Center, Department of Anaesthesiology, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Immunol Lett 91:147-54. 2004
    ..Involvement of mast cells is relatively easy to detect by measurement of tryptase...
  10. ncbi Inflammatory mediators are altered in the acute phase of posttraumatic complex regional pain syndrome
    Christian Schinkel
    Department of Surgery, Ruhr University, Bochum, Germany
    Clin J Pain 22:235-9. 2006
    ..The pathogenesis of this syndrome is unclear. It has clinical signs of severe local inflammation as a result of an exaggerated inflammatory response, but neurogenic dysregulation also may contribute to it...
  11. ncbi A hypothesis for the cause of complex regional pain syndrome-type I (reflex sympathetic dystrophy): pain due to deep-tissue microvascular pathology
    Terence J Coderre
    Department of Anesthesia, Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada
    Pain Med 11:1224-38. 2010
    Complex regional pain syndrome-type I (CRPS-I; reflex sympathetic dystrophy) is a chronic pain condition that usually follows a deep-tissue injury such as fracture or sprain. The cause of the pain is unknown...
  12. ncbi Successful treatment of CRPS 1 with anti-TNF
    Frank J P M Huygen
    J Pain Symptom Manage 27:101-3. 2004
  13. ncbi Increased skin lactate in complex regional pain syndrome: evidence for tissue hypoxia?
    F Birklein
    Neurologische Klinik, Friedrich Alexander Universität Erlangen, Germany
    Neurology 55:1213-5. 2000
    ..95 mmol/L; control subjects 1.74 mmol/L; p < 0.005). These results suggest enhanced anaerobic glycolysis, probably as a result of chronic tissue hypoxia...
  14. ncbi Biphosphonates for the therapy of complex regional pain syndrome I--systematic review
    Florian Brunner
    Department of Physical Medicine and Rheumatology, Balgrist University Hospital, Forchstrasse 340, 8008 Zurich, Switzerland
    Eur J Pain 13:17-21. 2009
    ..We performed a systematic review of all randomised controlled trials to assess the benefit of biphosphonates in the treatment of CRPS I patients with bone loss...
  15. pmc Evidence based guidelines for complex regional pain syndrome type 1
    Roberto S Perez
    VU University Medical Center, Department of Anaesthesiology, Amsterdam, The Netherlands
    BMC Neurol 10:20. 2010
    ..Treatment of complex regional pain syndrome type I (CRPS-I) is subject to discussion. The purpose of this study was to develop multidisciplinary guidelines for treatment of CRPS-I...
  16. ncbi Concordance of qualitative bone scintigraphy results with presence of clinical complex regional pain syndrome 1: meta-analysis of test accuracy studies
    R Ringer
    Department of Physical Medicine and Rheumatology, Balgrist University Hospital, Zurich, Switzerland
    Eur J Pain 16:1347-56. 2012
    ..To date, no attempt has been made to investigate the agreement between qualitative bone scintigraphy (BS) and the presence of complex regional pain syndrome 1 (CRPS 1) and the agreement between a negative BS in the absence of CRPS 1...
  17. ncbi Predictive value of symptom level measurements for complex regional pain syndrome type I
    R S G M Perez
    Department of Anesthesiology, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur J Pain 9:49-56. 2005
    ..We conclude that the measured pain, temperature, volume and range of motion can be used as diagnostic indicators for establishing presence or absence of CRPS I...
  18. ncbi Truths, errors, and lies around "reflex sympathetic dystrophy" and "complex regional pain syndrome"
    J L Ochoa
    Department of Neurology, Good Samaritan Hospital and Oregon Health Sciences University, 1040 NW 22nd Ave N 460, Portland, OR 97210, USA
    J Neurol 246:875-9. 1999
    The shifting paradigm of reflex sympathetic dystrophy-sympathetically maintained pains-complex regional pain syndrome is characterized by vestigial truths and understandable errors, but also unjustifiable lies...
  19. ncbi Meta-analysis of imaging techniques for the diagnosis of complex regional pain syndrome type I
    Zachary J Cappello
    School of Medicine and Division of Plastic Surgery, University of Louisville, Louisville, KY, USA
    J Hand Surg Am 37:288-96. 2012
    ..To compare the effectiveness of imaging techniques in aiding and confirming the diagnosis of complex regional pain syndrome (CRPS) type I...
  20. ncbi Demographic and medical parameters in the development of complex regional pain syndrome type 1 (CRPS1): prospective study on 596 patients with a fracture
    Annemerle Beerthuizen
    Department of Medical Psychology and Psychotherapy, Erasmus MC, Rotterdam, The Netherlands
    Pain 153:1187-92. 2012
    ..After a fracture, 7% of the patients developed CRPS1 and none of the patients were free of symptoms at 1-year follow-up...
  21. ncbi Diagnostic criteria for CRPS I: differences between patient profiles using three different diagnostic sets
    Roberto S G M Perez
    Department of Anesthesiology, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Pain 11:895-902. 2007
    ....
  22. ncbi [Current concepts in pathophysiology of CRPS I]
    F T Nickel
    Universitat Erlangen, Neurologische Klinik, Erlangen
    Handchir Mikrochir Plast Chir 42:8-14. 2010
    ..These pathophysiological ideas do not exclude each other. In fact they complement one another. The variety of the involved systems may explain the versatile clinical picture of CRPS...
  23. ncbi Treatment of reflex sympathetic dystrophy of the hand with an active "stress loading" program
    H K Watson
    Connecticut Combined Hand Service, Hartford Hospital, Conn
    J Hand Surg Am 12:779-85. 1987
    b>Reflex sympathetic dystrophy (RSD) is a syndrome characterized by pain out of proportion to injury, vasomotor and trophic changes, stiffness, and decreased function...
  24. ncbi Complex regional pain syndrome (reflex sympathetic dystrophy) in a patient with essential mixed cryoglobulinemia and chronic hepatitis C
    Ankur Bant
    Department of Internal Medicine, Maricopa Integrated Health System, Phoenix, AZ 85008, USA
    J Pak Med Assoc 57:96-8. 2007
    ..Complex Regional Pain Syndrome type I (CRPS) or Reflex sympathetic dystrophy (RSD) has never been reported in association with HCV...
  25. ncbi Pain exposure physical therapy may be a safe and effective treatment for longstanding complex regional pain syndrome type 1: a case series
    Jan Willem Ek
    Department of Rehabilitation Medicine, Bethesda Hospital, Hoogeveen
    Clin Rehabil 23:1059-66. 2009
    ..To determine if treatment of longstanding complex regional pain syndrome type 1, focusing on functional improvement only while neglecting pain, results in clinical improvement of this syndrome...
  26. ncbi Safety of "pain exposure" physical therapy in patients with complex regional pain syndrome type 1
    Hendrik van de Meent
    Department of Rehabilitation, Nijmegen Centre of Evidence Based Practice, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Pain 152:1431-8. 2011
    ..A progressive-loading exercise program and management of pain-avoidance behavior without the use of specific medication ("pain exposure" physical therapy) is safe and effective for patients with complex regional pain syndrome...
  27. ncbi Evidence for immune system involvement in reflex sympathetic dystrophy
    J S Calder
    Blond McIndoe Research Centre, Queen Victoria Hospital, East Grinstead, UK
    J Hand Surg Br 23:147-50. 1998
    Skin biopsies from patients with reflex sympathetic dystrophy were immunostained using a variety of antisera. An incidental finding with S100 staining was the presence of numerous Langerhans cells in the epidermis...
  28. ncbi Graded motor imagery is effective for long-standing complex regional pain syndrome: a randomised controlled trial
    G L Moseley
    Department of Physiotherapy, The University of Queensland and Royal Brisbane and Women s Hospital, Herston, 4029 Brisbane, QLD, Australia
    Pain 108:192-8. 2004
    ..Although the mechanisms of effect of the MIP are not clear, possible explanations are sequential activation of cortical pre-motor and motor networks, or sustained and focussed attention on the affected limb, or both...
  29. ncbi Graded motor imagery for pathologic pain: a randomized controlled trial
    G Lorimer Moseley
    Department of Physiology, Anatomy and Genetics and fMRIB Centre, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Neurology 67:2129-34. 2006
    ..Graded motor imagery is effective for a small subset of patients with CRPS1...
  30. ncbi Clinical aspects of multifocal or generalized tonic dystonia in reflex sympathetic dystrophy
    J J van Hilten
    Department of Neurology, Leiden University Medical Center, The Netherlands
    Neurology 56:1762-5. 2001
    The authors describe 10 patients with reflex sympathetic dystrophy that progressed to a multifocal or generalized tonic dystonia...
  31. ncbi Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome-I (reflex sympathetic dystrophy)
    Anne Louise Oaklander
    Nerve Injury Unit, Departments of Anesthesiology, Neurology, and Neuropathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Pain 120:235-43. 2006
    ..These results support the hypothesis that CRPS-I is specifically associated with post-traumatic focal MDNI affecting nociceptive small-fibers. This type of nerve injury will remain undetected in most clinical settings...
  32. ncbi Factitious disorders encountered in patients with the diagnosis of reflex sympathetic dystrophy
    Mehmet Ali Taskaynatan
    Department of Physical Medicine and Rehabilitation, Gulhane Military Medical Academy, 06018, Etlik Ankara, Turkey
    Clin Rheumatol 24:521-6. 2005
    b>Reflex sympathetic dystrophy (RSD) may be a misdiagnosis or at least not descriptive enough in patients with atypical hand posture and atypical edema...
  33. ncbi Pain and reduced mobility in complex regional pain syndrome I: outcome of a prospective randomised controlled clinical trial of adjuvant physical therapy versus occupational therapy
    H M Oerlemans
    Allied Health Services, University Hospital Nijmegen, P O Box 9101, 6500 HB, Nijmegen, Netherlands
    Pain 83:77-83. 1999
    ..Our results indicated that PT, and to a lesser extent OT, were helpful for reducing pain and improving active mobility in patients with CRPS I of less than one year duration, localised in one upper extremity...
  34. ncbi Treatment of complex regional pain syndrome type I
    Tymour Forouzanfar
    Pain Management and Research Centre, Department of Anesthesiology, University Hospital Maastricht, The Netherlands
    Eur J Pain 6:105-22. 2002
    b>Reflex sympathetic dystrophy (RSD), also known as complex regional pain syndrome type I (CRPS I), is a disabling neuropathic pain syndrome...
  35. ncbi Correlation between a novel upper limb activity monitor and four other instruments to determine functioning in upper limb complex regional pain syndrome type I
    Fabienne C Schasfoort
    Department of Rehabilitation Medicine, Erasmus MC, Rotterdam, The Netherlands
    J Rehabil Med 37:108-14. 2005
    ....
  36. ncbi Neurophysiologic aspects of patients with generalized or multifocal tonic dystonia of reflex sympathetic dystrophy
    Willem Johan T van de Beek
    Department of Neurology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Clin Neurophysiol 19:77-83. 2002
    b>Reflex sympathetic dystrophy (RSD) is a syndrome dominated by sensory, autonomic, and motor features of the extremities...
  37. ncbi Complex regional pain syndrome I (reflex sympathetic dystrophy)
    Srinivasa N Raja
    Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Anesthesiology 96:1254-60. 2002
  38. ncbi Chronic post-ischemia pain (CPIP): a novel animal model of complex regional pain syndrome-type I (CRPS-I; reflex sympathetic dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat
    Terence J Coderre
    Department of Anesthesia, Anesthesia Research Unit, McGill University, Room 1203, McIntyre Bldg, 3655 Drummond St, Montreal, Que, Canada H3G 1Y6
    Pain 112:94-105. 2004
    ..ischemia and reperfusion, creating an animal model of complex regional pain syndrome-Type I (CRPS-I; reflex sympathetic dystrophy) that we call chronic post-ischemia pain (CPIP)...
  39. ncbi Reflex sympathetic dystrophy: a multidisciplinary approach
    Susan M Maillard
    Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    Arthritis Rheum 51:284-90. 2004
  40. ncbi Economic evaluation of spinal cord stimulation for chronic reflex sympathetic dystrophy
    Marius A Kemler
    Department of Surgery, Maastricht University Hospital, Maastricht, The Netherlands
    Neurology 59:1203-9. 2002
    To evaluate the economic aspects of treatment of chronic reflex sympathetic dystrophy (RSD) with spinal cord stimulation (SCS), using outcomes and costs of care before and after the start of treatment.
  41. ncbi The effect of spinal cord stimulation in patients with chronic reflex sympathetic dystrophy: two years' follow-up of the randomized controlled trial
    Marius A Kemler
    Department of Plastic Surgery, Medical Center Leeuwarden, Leeuwarden
    Ann Neurol 55:13-8. 2004
    Chronic reflex sympathetic dystrophy is a painful, disabling disorder for which no treatment with proven effect is available...
  42. pmc Evidence for local inflammation in complex regional pain syndrome type 1
    Frank J P M Huygen
    Department of Anesthesiology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Mediators Inflamm 11:47-51. 2002
    ..Peripheral afferent, efferent and central mechanisms are supposed. Based on clinical signs and symptoms (e.g. oedema, local temperature changes and chronic pain) local inflammation is suspected...
  43. ncbi The treatment of complex regional pain syndrome type I with free radical scavengers: a randomized controlled study
    R S G M Perez
    Department of Anesthesiology, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Pain 102:297-307. 2003
    ..Strong indications exist for differences in effects for subgroups of patients with warm or cold CRPS I: for warm CRPS I, DMSO-treatment appears more favorable, while for cold CRPS I, NAC-treatment appears to be more effective...
  44. ncbi Impairments as measured by ISS do not greatly change between one and eight years after CRPS 1 diagnosis
    Michiel Vaneker
    Pain Centre, Department of Anaesthesiology, Radboud University Medical Centre Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur J Pain 10:639-44. 2006
    ..e. "warm" or "cold", diagnosed according to skin temperature measured via infrared thermometer)...
  45. ncbi The usefulness of quantitative evaluation of three-phase scintigraphy in the diagnosis of post-traumatic reflex sympathetic dystrophy
    A Zyluk
    Department of General and Hand Surgery, Pomeranian Medical University, Szczecin, Poland
    J Hand Surg Br 24:16-21. 1999
    Quantitative analysis of three-phase bone scintigrams was done in 70 patients with reflex sympathetic dystrophy (RSD) and in 30 patients who did not have RSD after injury to the hand or wrist...
  46. ncbi Evaluation of three methods to rate impairment in patients with complex regional pain syndrome I of one upper extremity
    H M Oerlemans
    Allied Health Services, University Medical Center Nijmegen, The Netherlands
    Clin Rehabil 14:331-9. 2000
    ..To gain insight into the best way of obtaining an impairment rating in complex regional pain syndrome I (CRPS I) of the upper extremity. This syndrome can potentially result in permanent impairment...
  47. pmc Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate cold type complex regional pain syndrome type 1
    J George Groeneweg
    Department of Anesthesiology, subdivision Pain Treatment Center, Erasmus MC Rotterdam, The Netherlands
    BMC Musculoskelet Disord 7:91. 2006
    ..The aim of this study was to determine the involvement of vasoactive substances endothelin-1 (ET-1) and nitric oxide (NO) during early chronic CRPS1...
  48. ncbi Vascular abnormalities in reflex sympathetic dystrophy (CRPS I): mechanisms and diagnostic value
    G Wasner
    , , Kiel, Niemannsweg 147, 24105 Kiel, Germany
    Brain 124:587-99. 2001
    Complex regional pain syndrome type I (CRPS I, formerly known as reflex sympathetic dystrophy) is a painful neuropathic disorder that develops after trauma affecting the limbs without overt nerve injury...
  49. ncbi Spinal cord stimulation for chronic reflex sympathetic dystrophy--five-year follow-up
    Marius A Kemler
    N Engl J Med 354:2394-6. 2006
  50. ncbi Proprioceptive reflexes in patients with reflex sympathetic dystrophy
    A C Schouten
    Delft University of Technology, Department of Mechanical Engineering, Man Machine Systems and Control, Mekelweg 2, 2628 CD Delft, Leiden, The Netherlands
    Exp Brain Res 151:1-8. 2003
    b>Reflex sympathetic dystrophy (RSD) is a syndrome that frequently follows an injury and is characterized by sensory, autonomic and motor features of the affected extremities...
  51. ncbi Diagnosing sensory abnormalities with either normal values or values from contralateral skin: comparison of two approaches in complex regional pain syndrome I
    M A Kemler
    Department of Surgery, Maastricht University Hospital, Maastricht, The Netherlands
    Anesthesiology 93:718-27. 2000
    ..The current study gives normal values for both approaches and compares the advantages of each method by applying the technique to patients with complex regional pain syndrome type I (CRPS I)...
  52. ncbi Signs and symptoms in complex regional pain syndrome type I/reflex sympathetic dystrophy: judgment of the physician versus objective measurement
    H M Oerlemans
    Allied Health Services, University Hospital Nijmegen, The Netherlands
    Clin J Pain 15:224-32. 1999
    ..To assess the relation between the subjectively assessed and objectively measured diagnostic signs and symptoms in complex regional pain syndrome type I (CRPS I) and to quantify their severity...
  53. ncbi Reflex sympathetic dystrophy: complex regional pain syndrome type I in children with mitochondrial disease and maternal inheritance
    T Higashimoto
    Division of Medical Genetics and the Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, California, USA
    Arch Dis Child 93:390-7. 2008
    Complex regional pain syndrome type I (CRPS-I), previously known as reflex sympathetic dystrophy (RSD), is an idiopathic condition characterised by localised, abnormally intense and prolonged pain, allodynia and autonomic nervous system ..
  54. ncbi Reflex sympathetic dystrophy following arterial blood gas sampling in the intensive care setting
    C Criscuolo
    Department of Medicine, University of Nebraska Medical Center, Omaha, USA
    Chest 108:578-80. 1995
    A 54-year-old woman developed signs and symptoms consistent with reflex sympathetic dystrophy in her left upper extremity following arterial puncture...
  55. ncbi Intravenous clodronate in the treatment of reflex sympathetic dystrophy syndrome. A randomized, double blind, placebo controlled study
    M Varenna
    Department of Rheumatology, Istituto Ortopedico Gaetano Pini, Milano, Italy
    J Rheumatol 27:1477-83. 2000
    To evaluate the efficacy of intravenous (i.v.) clodronate in patients with reflex sympathetic dystrophy syndrome (RSDS) and to assess the urinary excretion of type I collagen crosslinked N-telopeptide (NTx) before and after the treatment.
  56. ncbi Endothelial dysfunction in cold type complex regional pain syndrome
    J Schattschneider
    Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Neurology 67:673-5. 2006
    ..No significant differences were found after application of sodium nitroprusside. The results demonstrate impaired endothelial function in chronic CRPS I...
  57. ncbi Intrathecal baclofen for the treatment of dystonia in patients with reflex sympathetic dystrophy
    B J van Hilten
    Department of Neurology, Leiden University Medical Center, The Netherlands
    N Engl J Med 343:625-30. 2000
    Patients with reflex sympathetic dystrophy (also known as the complex regional pain syndrome) may have dystonia, which is often unresponsive to treatment...
  58. ncbi Skin temperature side differences--a diagnostic tool for CRPS?
    Gunnar Wasner
    Klinik fur Neurologie, Universitätsklinikum Kiel der Christian Albrechts Universität, Niemannsweg 147, 24105 Kiel, Germany
    Pain 98:19-26. 2002
    ..Taking this into consideration, skin temperature differences in the distal limbs are capable of reliably distinguishing CRPS I from other extremity pain syndromes with high sensitivity and specificity...
  59. ncbi The effect of gabapentin in earlier stage of reflex sympathetic dystrophy
    Arif Kenan Tan
    Department of Physical Medicine and Rehabilitation, Gulhane Military Medical Academy, 06018 Etlik, Ankara, Turkey
    Clin Rheumatol 26:561-5. 2007
    The objective of this paper is to investigate the effect of gabapentin in the earlier stage of reflex sympathetic dystrophy syndrome (RSD). Twenty-two patients diagnosed with RSD were enrolled. Initial gabapentin dosage was 600 mg/day...
  60. ncbi A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes
    W S Kingery
    Physical Medicine and Rehabilitation Service, Veterans Affairs Palo Alto Health Care System, CA 94304, USA
    Pain 73:123-39. 1997
    ..There was almost no overlap in the controlled trial literature between treatments for PNP and CRPS, and treatments used in both conditions (intravenous phentolamine and epidural clonidine) had similar results...
  61. ncbi Incidence of complex regional pain syndrome type I after fractures of the distal radius
    Pieter U Dijkstra
    Department of Rehabilitation, University Hospital Groningen, PO Box 30 001, 9700 RB, Groningen, The Netherlands
    Eur J Pain 7:457-62. 2003
    ..2 to 6%) after fractures of the distal radius. Further the risk factors described in literature play a minor role in the development of CRPS-I...
  62. ncbi Reflex sympathetic dystrophy: a retrospective epidemiological study of 168 patients
    Iltekin Duman
    Department of Physical Medicine and Rehabilitation, Gulhane Military Medical Academy, 06018, Etlik, Ankara, Turkey
    Clin Rheumatol 26:1433-7. 2007
    ..factors, duration of symptoms, treatment modalities applied and clinical outcome of the treatment in reflex sympathetic dystrophy (RSD)...
  63. ncbi Reflex sympathetic dystrophy: treatment with long-acting intramuscular corticosteroids
    A B Grundberg
    Division of Hand Surgery, Des Moines Orthopaedic Surgeons, West Des Moines, IA, USA
    J Hand Surg Am 21:667-70. 1996
    In an 8-year period, 69 patients with reflex sympathetic dystrophy, who were followed at least 1 year, were treated with active exercises and injections of long-acting methylprednisolone...
  64. pmc Randomised controlled trial of gabapentin in Complex Regional Pain Syndrome type 1 [ISRCTN84121379]
    Anton C van de Vusse
    Pain Management and Research Centre, Dept of Anesthesiology, University Hospital Maastricht, Maastricht, The Netherlands
    BMC Neurol 4:13. 2004
    Complex Regional Pain Syndrome type one (CRPS I) or formerly Reflex Sympathetic Dystrophy (RSD) is a disabling syndrome, in which a painful limb is accompanied by varying symptoms...
  65. ncbi Sympathetic skin responses in reflex sympathetic dystrophy
    K Bolel
    Department of Physical Medicine and Rehabilitation, Cumhuriyet University School of Medicine, 58140 Sivas, Turkey
    Rheumatol Int 26:788-91. 2006
    ..SSR) in evaluating the sympathetic function and to follow up the effects of sympathetic blockade in reflex sympathetic dystrophy (RSD)...
  66. ncbi Determination of inflammation of reflex sympathetic dystrophy at early stages with Tc-99m HIG scintigraphy: preliminary results
    Berna Okudan
    Department of Nuclear Medicine, Ankara Numune Research and Training Hospital, Ankara, Turkey
    Rheumatol Int 26:404-8. 2006
    The pathogenesis of reflex sympathetic dystrophy (RSD) is not completely understood...
  67. ncbi Efficacy of salmon calcitonin in complex regional pain syndrome (type 1) in addition to physical therapy
    Fusun Sahin
    Department of Physical Medicine and Rehabilitation, Sisli Etfal Education and Research Hospital, Istanbul, Turkey
    Clin Rheumatol 25:143-8. 2006
    ..We can conclude that calcitonin does not make any favourable contribution in the treatment of patients with acute CRPS 1; physical therapy combined with only a simple analgesic is an efficient means of therapy...
  68. ncbi Spinal cord stimulation in sympathetically maintained complex regional pain syndrome type I with severe disability. A prospective clinical study
    Henning Harke
    Department of Anesthesia and Pain Therapy, Klinikum Krefeld, Lutherplatz 40, D 47805 Krefeld, Germany
    Eur J Pain 9:363-73. 2005
    ..In this prospective trial we assessed the long-term effect of spinal cord stimulation (SCS) on the improvement of functional status in complex regional pain syndrome type I (CRPS I)...
  69. ncbi Efficacy of stellate ganglion blockade for the management of type 1 complex regional pain syndrome
    William E Ackerman
    Pain Medicine Consultants PA, Little Rock, AR, USA
    South Med J 99:1084-8. 2006
    ..The purpose of this study was to examine the efficacy of stellate ganglion blockade (SGB) in patients with complex regional pain syndromes (CRPS I) of their hands...
  70. ncbi Sensorimotor retuning [corrected] in complex regional pain syndrome parallels pain reduction
    Burkhard Pleger
    Department of Neurology, BG Kliniken Bergmannsheil, Ruhr University Bochum, Buerkle de la Camp Platz 1, DD 47789 Bochum, Germany
    Ann Neurol 57:425-9. 2005
    ..This suggests that the reversal of tactile impairment and cortical reorganization in CRPS is associated with a decrease in pain...
  71. ncbi Pathologic alterations of cutaneous innervation and vasculature in affected limbs from patients with complex regional pain syndrome
    Phillip J Albrecht
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY, USA
    Pain 120:244-66. 2006
    ..CRPS type I, also known as reflex sympathetic dystrophy, presents in patients lacking a well-defined nerve lesion, and has been questioned as to whether or not ..
  72. ncbi Continuous peripheral nerve blocks at home for treatment of recurrent complex regional pain syndrome I in children
    Christophe Dadure
    Department of Anesthesia and Critical Care Medicine, Lapeyronie University Hospital, Montpellier, France
    Anesthesiology 102:387-91. 2005
    ....
  73. ncbi Exaggeration of tissue trauma induces signs and symptoms of acute CRPS I, however displays distinct differences to experimental CRPS II
    Georg Gradl
    Department of Trauma and Reconstructive Surgery, University of Rostock, Germany
    Neurosci Lett 402:267-72. 2006
    ..Pain perception displays differences to that in CRPS II. Apoptosis turns out to be a distinctive marker for CRPS, warranting further evaluation in clinical studies...
  74. pmc Intravenous regional anesthesia with ketorolac-lidocaine for the management of sympathetically-mediated pain
    N R Connelly
    Department of Anesthesiology, Tufts University School of Medicine, Baystate Medical Center, Springfield, Massachusetts, USA
    Yale J Biol Med 68:95-9. 1995
    ..Sixty-one patients with reflex sympathetic dystrophy presenting to a university-affiliated teaching hospital's pain management center were evaluated...
  75. ncbi Role of alendronate in therapy for posttraumatic complex regional pain syndrome type I of the lower extremity
    Daniel Henri Manicourt
    St Luc University Hospital, Universite Catholique de Louvain, 5390 Avenue Mounier, 1200 Brussels, Belgium
    Arthritis Rheum 50:3690-7. 2004
    ..To evaluate the effects of the antiresorptive agent alendronate at a daily oral dose of 40 mg in patients with posttraumatic complex regional pain syndrome type I (CRPS I) of the lower extremity...
  76. ncbi Magnetic resonance imaging in reflex sympathetic dystrophy syndrome of the foot
    Françoise Crozier
    Department of Radiology, CHU Timone, 254, rue St Pierre, 13385 Marseille Cedex 5, France
    Joint Bone Spine 70:503-8. 2003
    The purpose was to analyze magnetic resonance imaging (MRI) abnormalities in reflex sympathetic dystrophy syndrome (RSDS) of the foot, with the goal of helping to meet the difficult diagnostic challenges raised by this condition.
  77. ncbi Intravenous regional anesthesia with clonidine in the management of complex regional pain syndrome of the knee
    Scott S Reuben
    Department of Anesthesiology, Baystate Medical Center, Springfield, MA 01199, USA
    J Clin Anesth 14:87-91. 2002
    ..To evaluate the safety and efficacy of administering intravenous regional anesthesia (IVRA) with clonidine in the management of complex regional pain syndrome (CRPS) of the knee...
  78. ncbi Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1
    Marnix J Sigtermans
    Department of Anesthesiology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Pain 145:304-11. 2009
    ..Treatment with ketamine was safe with psychomimetic side effects that were acceptable to most patients...
  79. ncbi Measuring perceived activity limitations in lower extremity Complex Regional Pain Syndrome type 1 (CRPS I): test-retest reliability of two questionnaires
    Roberto S G M Perez
    Department of Anesthesiology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Clin Rehabil 16:454-60. 2002
    ..To assess the test-retest reliability of two questionnaires for measuring activity limitations in patients with Complex Regional Pain Syndrome type 1 (CRPS I) of the lower extremity...
  80. ncbi Management of lower limb complex regional pain syndrome type 1: an evaluation of percutaneous radiofrequency thermal lumbar sympathectomy versus phenol lumbar sympathetic neurolysis--a pilot study
    Prashanth S Manjunath
    Department of Anesthesiology, University of Miami Jackson Memorial Hospital, Miami, FL, USA
    Anesth Analg 106:647-9, table of contents. 2008
    ..The purpose of this study was to compare the safety and efficacy of two therapeutic options: percutaneous radiofrequency thermal lumbar sympathectomy and lumbar sympathetic neurolysis...
  81. ncbi Intravenous regional guanethidine blockade in the treatment of post-traumatic complex regional pain syndrome type 1 (algodystrophy) of the hand
    J A Livingstone
    University Department of Orthopaedic Surgery, Bristol Royal Infirmary, England, UK
    J Bone Joint Surg Br 84:380-6. 2002
    ..It does not improve the outcome of this condition and may delay the resolution of vasomotor instability when compared with the placebo...
  82. ncbi Is fibromyalgia a generalized reflex sympathetic dystrophy?
    M Martinez-Lavin
    Rheumatology Department, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano No 1, 14080 México D F Mexico
    Clin Exp Rheumatol 19:1-3. 2001
    Fibromyalgia and reflex sympathetic dystrophy share defining characteristics, namely chronic pain and allodynia, as well as other important clinical features such as onset after trauma, female predominance, paresthesias, vasomotor ..
  83. ncbi Reflex sympathetic dystrophy
    Robert J Schwartzman
    Department of Neurology, MCP Hahnemann University School of Medicine, Broad and Vine Streets, MS 423, Philadelphia, PA 19102 1192, USA
    Curr Rheumatol Rep 4:165-9. 2002
    b>Reflex sympathetic dystrophy (RSD) is composed of five major features: pain, swelling, autonomic dysregulation, movement disorders, and atrophy and dystrophy...
  84. ncbi Surgical sympathectomy for reflex sympathetic dystrophy syndromes
    Dennis F Bandyk
    Department of Vascular Surgery, University of South Florida College of Medicine, Tampa, USA
    J Vasc Surg 35:269-77. 2002
    The purpose of this study was the assessment of the efficacy of thoracoscopic cervicodorsal and open lumbar sympathectomy for the reduction of pain severity and disability associated with reflex sympathetic dystrophy (RSD).
  85. ncbi Treatment of patients with complex regional pain syndrome type I with mannitol: a prospective, randomized, placebo-controlled, double-blinded study
    Roberto S Perez
    VU University Medical Center, Department of Anesthesiology, Amsterdam, The Netherlands
    J Pain 9:678-86. 2008
    ..Whether 10% mannitol can provide beneficial effects for subgroups of CRPS I patients with a pathophysiological profile more closely fitting the presumed mode of action for this intervention remains to be established...
  86. ncbi Which patients with chronic reflex sympathetic dystrophy are most likely to benefit from physical therapy?
    M A Kemler
    Department of Surgery, Maastricht University Hospital, Maastricht, The Netherlands
    J Manipulative Physiol Ther 24:272-8. 2001
    Chronic reflex sympathetic dystrophy (RSD) is a painful and disabling disorder for which no treatment with proven effects exists...
  87. ncbi Preventing recurrence of reflex sympathetic dystrophy in patients requiring an operative intervention at the site of dystrophy after surgery
    C Marx
    Department of Rheumatology and Institute for Physical Medicine, University Hospital Zurich, Switzerland
    Clin Rheumatol 20:114-8. 2001
    The development of reflex sympathetic dystrophy (RSD) is a common complication after surgery. Exacerbation or recurrence of RSD is a major concern after a second intervention at the site of previous surgery and consecutive RSD...
  88. ncbi Clinical and physiologic evaluation of stellate ganglion blockade for complex regional pain syndrome type I
    M Schurmann
    Department of Surgery, Ludwig Maximilians University, Munich, Germany
    Clin J Pain 17:94-100. 2001
    ..Results were compared with clinical signs such as temperature changes, pain reduction, and the development of Horner syndrome to evaluate the correlation with clinical investigations...
  89. ncbi An open-label pilot trial of ibandronate for complex regional pain syndrome
    Brenda Breuer
    Department of Pain Medicine and Palliative Care, Beth Israel Medical Center, New York, NY 10003, USA
    Clin J Pain 24:685-9. 2008
    Complex regional pain syndrome (CRPS) type I, also known as reflex sympathetic dystrophy, usually develops after trauma or immobilization, is characterized by focal pain and autonomic dysregulation, and sometimes focal trophic changes ..
  90. ncbi The efficacy of manual lymphatic drainage therapy in the management of limb edema secondary to reflex sympathetic dystrophy
    Iltekin Duman
    Department of Physical Medicine and Rehabilitation, Gulhane Military Medical Academy, Etlik, 06018, Ankara, Turkey
    Rheumatol Int 29:759-63. 2009
    ..is to investigate the efficacy of manual lymphatic drainage (MLD) therapy in edema secondary to the reflex sympathetic dystrophy (RSD). A total of 34 patients were allocated randomly into two groups...
  91. ncbi Intravenous magnesium for complex regional pain syndrome type 1 (CRPS 1) patients: a pilot study
    Susan Collins
    Department of Anesthesiology, VU University Medical Center, Amsterdam, The Netherlands
    Pain Med 10:930-40. 2009
    ..To explore the feasibility of intravenous magnesium administration as a potential candidate intervention for a large size trial in Complex Regional Pain Syndrome Type 1 (CRPS 1)...
  92. ncbi Short- and long-term outcomes of children with complex regional pain syndrome type I treated with exercise therapy
    D D Sherry
    Department of Pediatrics, University of Washington, Children s Hospital and Medical Center, Seattle 98105, USA
    Clin J Pain 15:218-23. 1999
    ..To report the initial and long-term outcome after an intensive exercise therapy program for childhood complex regional pain syndrome, type I (CRPS)...
  93. ncbi The Radboud skills questionnaire: construction and reliability in patients with reflex sympathetic dystrophy of one upper extremity
    H M Oerlemans
    Allied Health Services, University Hospital Nijmegen, The Netherlands
    Disabil Rehabil 22:233-45. 2000
    ..To construct a questionnaire to measure skills in which notably both hands are active, which is suitable for patients with a disease of one or both hands and to research its response stability and possible improvements...
  94. ncbi Complex regional pain syndrome type I induced by pacemaker implantation, with a good response to steroids and neurotropin
    Makoto Okada
    Internal Medicine I, National Defense Medical College, Tokorozawa, Saitama
    Intern Med 41:498-501. 2002
    ..She was diagnosed to have CRPS-I, which was considered to have been induced by the pacemaker implantation. After treatment with methylprednisolone and Neurotropin, her symptoms dramatically improved...
  95. ncbi Spinal cord stimulation in adolescents with complex regional pain syndrome type I (CRPS-I)
    Gunnar L Olsson
    Pain Treatment Unit, Astrid Lindgren Children s Hospital, 17176, Stockholm, Sweden
    Eur J Pain 12:53-9. 2008
    ....
  96. ncbi Can vitamin C prevent complex regional pain syndrome in patients with wrist fractures? A randomized, controlled, multicenter dose-response study
    P E Zollinger
    Department of Surgery, Red Cross Hospital, Beverwijk, The Netherlands
    J Bone Joint Surg Am 89:1424-31. 2007
    ..Complex regional pain syndrome type I is treated symptomatically. A protective effect of vitamin C (ascorbic acid) has been reported previously. A dose-response study was designed to evaluate its effect in patients with wrist fractures...
  97. ncbi Vasodilative effect of isosorbide dinitrate ointment in complex regional pain syndrome type 1
    George Groeneweg
    Department of Anesthesiology, Subdivision Pain Treatment Centre, Erasmus MC, Rotterdam, The Netherlands
    Clin J Pain 24:89-92. 2008
    ..Pharmacotherapeutic treatment is generally inadequate...
  98. ncbi [Vitamin C and prevention of reflex sympathetic dystrophy following surgical management of distal radius fractures]
    J F Cazeneuve
    Service de Chirurgie Orthopedique et Traumatologique, Centre Hospitalier, Rue Marcellin Berthelot, 02 000 Laon, France
    Acta Orthop Belg 68:481-4. 2002
    b>Reflex sympathetic dystrophy is a major complication following surgical treatment of fractures of the distal radius...
  99. ncbi Sympathetic nervous system and pain: a clinical reappraisal
    H Blumberg
    Department of Neurosurgery, University of Freiburg, Germany
    Behav Brain Sci 20:426-34; discussion 435-513. 1997
    ..To this end, the patients under study are divided into three groups. In the first group, called "reflex sympathetic dystrophy" (RSD), the syndrome can be characterized by a triad of autonomic, motor, and sensory symptoms, which ..
  100. ncbi [A hairy condition]
    Renate Wiesner
    MMW Fortschr Med 146:57. 2004
  101. ncbi Acute posttraumatic ischemia of the limbs: algodystrophy or related syndrome? A prospective study on a series of 25 patients
    Marc Antoine Pistorius
    Department of Internal and Vascular Medicine, University Hospital Hotel Dieu, Nantes, France
    Angiology 59:301-5. 2008
    ..The symptoms may recur, but they respond to physiotherapy. Patients' follow-up showed that microcirculatory function remains abnormal sometime after the initial episode with, in particular, an exacerbation of the venoarteriolar reflex...

Research Grants12

  1. Opioid Efficacy In Humans: A Twin Study
    DAVID J contact CLARK; Fiscal Year: 2010
    ....
  2. Inflammasome Activation in Complex Regional Pain Syndrome
    Wade S Kingery; Fiscal Year: 2013
    ....
  3. MECHANISM OF NOCICEPTION INDUCED BY INNOCUOUS COLD IN TRIGEMINAL SYSTEM
    Jianguo Gu; Fiscal Year: 2012
    Orofacial pain disorders encompass a wide range of conditions including trigeminal neuralgia, reflex sympathetic dystrophy (RSD) of the face, temporomandibular joint disorders, periodontal pain, burning mouth syndrome, dental surgical ..
  4. POSTMORTEM STUDIES OF PAINFUL PERIPHERAL NEUROPATHY
    VIRGINIA SEYBOLD; Fiscal Year: 1991
    ..Tissue donors with pre-morbid history of reflex sympathetic dystrophy or causalgia will be the primary focus of this work because of the similarity between the symptoms and ..
  5. SYMPATHETIC EFFERENT MODULATION OF PAIN
    William Roberts; Fiscal Year: 1993
    ..research program is to understand the physiology of sympathetically dependent pain, such as that in reflex sympathetic dystrophy, acute herpes zoster and some cases of low back pain...
  6. Neurite density in skin as a marker for neuropathic pain
    Anne Louise Oaklander; Fiscal Year: 2005
    ..abstract_text> ..
  7. Mentored Patient-Oriented Research Career Development Aw
    Paola Sandroni; Fiscal Year: 2004
    ..Sandroni with the necessary conceptual development, publications track record and investigational tools to effectively compete as an independent investigator in autonomic disorders in future years. ..
  8. The Roles of Heme Oxygenase in Pain
    David Clark; Fiscal Year: 2005
    ....
  9. Genetics of Opioid Induced Hyperalgesia
    David Clark; Fiscal Year: 2004
    ..Thus our overall goal is to bring a unique and complimentary approach to the ongoing studies of OIH by using genomics to objectively identify genes involved in this phenomenon. ..
  10. MECHANISMS FOR TOLERANCE TO ACTIONS OF A2 AGONISTS
    David Clark; Fiscal Year: 2002
    ..Data from these studies can be used to develop therapeutic strategies to prevent or reverse tolerance. ..
  11. Nasal Delivery of Naltrexone for Treatment of Alcoholism
    Daniel Wermeling; Fiscal Year: 2006
    ..The long-term goal of this work is to develop and commercialize nasal delivered NTX for the treatment of alcoholism. [unreadable] [unreadable] [unreadable]..