autonomic nervous system diseases

Summary

Summary: Diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.

Top Publications

  1. ncbi Diabetic autonomic neuropathy
    Aaron I Vinik
    Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, Norfolk 23510, USA
    Diabetes Care 26:1553-79. 2003
  2. ncbi Diabetic neuropathies: a statement by the American Diabetes Association
    Andrew J M Boulton
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, U K
    Diabetes Care 28:956-62. 2005
  3. ncbi Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats: role in functional capacity and mortality
    Luciana Jorge
    Hypertension Unit, Heart Institute InCor, Medical School of University of São Paulo, Av Dr Eneas de Carvalho Aguiar 44 Subsolo, Sao Paulo, SP, Brazil
    Eur Heart J 32:904-12. 2011
  4. ncbi Practice Parameter: evaluation of distal symmetric polyneuropathy: role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review). Report of the American Academy of Neurology, American Association of Neuromuscular and Electrodiagnosti
    J D England
    American Academy of Neurology, St Paul, MN 55116, USA
    Neurology 72:177-84. 2009
  5. ncbi Autonomic impairment after myocardial infarction: role in cardiac remodelling and mortality
    Cristiano Mostarda
    Hypertension Unit, Heart Institute InCor, Medical School, University of Sao Paulo, Sao Paulo, Brazil
    Clin Exp Pharmacol Physiol 37:447-52. 2010
  6. ncbi Blood pressure recovery from Valsalva maneuver in patients with autonomic failure
    Elizabeth R Vogel
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 65:1533-7. 2005
  7. ncbi Bromocriptine for the management of autonomic dysfunction after severe traumatic brain injury
    R N Russo
    Department of Rehabilitation Medicine, Royal Alexandra Hospital for Children, Parramatta, New South Wales, Australia
    J Paediatr Child Health 36:283-5. 2000
  8. ncbi Symptoms of autonomic dysfunction in chronic fatigue syndrome
    J L Newton
    Fatigue Interest group and Liver Research Group, Institute for Cellular Medicine, University of Newcastle, Newcastle, UK
    QJM 100:519-26. 2007
  9. ncbi Cognitive functioning in orthostatic hypotension due to pure autonomic failure
    Hannah C Heims
    Dept of Neuropsychology, Box 37, National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    Clin Auton Res 16:113-20. 2006
  10. ncbi Autonomic dysfunction in dementia with Lewy bodies
    P Thaisetthawatkul
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 62:1804-9. 2004

Research Grants

Detail Information

Publications238 found, 100 shown here

  1. ncbi Diabetic autonomic neuropathy
    Aaron I Vinik
    Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, Norfolk 23510, USA
    Diabetes Care 26:1553-79. 2003
    ..Finally, knowledge of early autonomic dysfunction can encourage patient and physician to improve metabolic control and to use therapies such as ACE inhibitors and beta-blockers, proven to be effective for patients with CAN...
  2. ncbi Diabetic neuropathies: a statement by the American Diabetes Association
    Andrew J M Boulton
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, U K
    Diabetes Care 28:956-62. 2005
  3. ncbi Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats: role in functional capacity and mortality
    Luciana Jorge
    Hypertension Unit, Heart Institute InCor, Medical School of University of São Paulo, Av Dr Eneas de Carvalho Aguiar 44 Subsolo, Sao Paulo, SP, Brazil
    Eur Heart J 32:904-12. 2011
    ..To test the effects of early exercise training (ET) on left ventricular (LV) and autonomic functions, haemodynamics, tissues blood flows (BFs), maximal oxygen consumption (VO(2) max), and mortality after myocardial infarction (MI) in rats...
  4. ncbi Practice Parameter: evaluation of distal symmetric polyneuropathy: role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review). Report of the American Academy of Neurology, American Association of Neuromuscular and Electrodiagnosti
    J D England
    American Academy of Neurology, St Paul, MN 55116, USA
    Neurology 72:177-84. 2009
    ....
  5. ncbi Autonomic impairment after myocardial infarction: role in cardiac remodelling and mortality
    Cristiano Mostarda
    Hypertension Unit, Heart Institute InCor, Medical School, University of Sao Paulo, Sao Paulo, Brazil
    Clin Exp Pharmacol Physiol 37:447-52. 2010
    ..These data highlight the importance of this mechanism in the prognosis of patients after an ischaemic event...
  6. ncbi Blood pressure recovery from Valsalva maneuver in patients with autonomic failure
    Elizabeth R Vogel
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 65:1533-7. 2005
    ..Blood pressure (BP) changes in response to the Valsalva maneuver (VM) reflect the integrity of the baroreflex that regulates BP, and the phases of VM are widely used indices of adrenergic evaluation...
  7. ncbi Bromocriptine for the management of autonomic dysfunction after severe traumatic brain injury
    R N Russo
    Department of Rehabilitation Medicine, Royal Alexandra Hospital for Children, Parramatta, New South Wales, Australia
    J Paediatr Child Health 36:283-5. 2000
    ..A history of severe asthma in this child contraindicated the use of beta-blockers, the first line approach, and she was managed with bromocriptine (0.05 mg/kg t.d.s) with good effect...
  8. ncbi Symptoms of autonomic dysfunction in chronic fatigue syndrome
    J L Newton
    Fatigue Interest group and Liver Research Group, Institute for Cellular Medicine, University of Newcastle, Newcastle, UK
    QJM 100:519-26. 2007
    ..Chronic fatigue syndrome (CFS) is common and its cause is unknown...
  9. ncbi Cognitive functioning in orthostatic hypotension due to pure autonomic failure
    Hannah C Heims
    Dept of Neuropsychology, Box 37, National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    Clin Auton Res 16:113-20. 2006
    ..However, a failure in integrated bodily arousal responses during cognitive behaviours may also contribute to some of the observed deficits...
  10. ncbi Autonomic dysfunction in dementia with Lewy bodies
    P Thaisetthawatkul
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 62:1804-9. 2004
    ..To assess autonomic function in patients with dementia with Lewy bodies (DLB)...
  11. ncbi Standardized tests of heart rate variability: normal ranges obtained from 309 healthy humans, and effects of age, gender, and heart rate
    M W Agelink
    Institute of Biological Psychiatry and Neuroscience at the Evangelical Clinics Gelsenkirchen, Ruhr-University of Bochum, Germany
    Clin Auton Res 11:99-108. 2001
    ..The authors computed age- and gender-dependent normal values for each of the HRV indices studied here and discuss the clinical consequences arising from gender differences in HRV...
  12. ncbi The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis
    Raelene E Maser
    Department of Medical Technology, University of Delaware, Newark, Delaware 19716, USA
    Diabetes Care 26:1895-901. 2003
    ..To examine by meta-analysis the relationship between cardiovascular autonomic neuropathy (CAN) and risk of mortality in individuals with diabetes...
  13. ncbi Prospective evaluation of somatic and autonomic small fibers in selected autonomic neuropathies
    W Singer
    Mayo Foundation, Rochester, MN, USA
    Neurology 62:612-8. 2004
    ..There are a number of distal and generalized small-fiber neuropathies. The neuropathologic basis is poorly understood as somatic and autonomic C fibers are not usually studied in the same region of the body...
  14. pmc DCCT and EDIC studies in type 1 diabetes: lessons for diabetic neuropathy regarding metabolic memory and natural history
    Rodica Pop-Busui
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Curr Diab Rep 10:276-82. 2010
    ..The lessons learned about the natural history of distal symmetrical polyneuropathy and cardiovascular autonomic neuropathy and the impact of glycemic control on neuropathy are discussed in this review...
  15. ncbi Cutaneous innervation in Guillain-Barré syndrome: pathology and clinical correlations
    Chun Liang Pan
    Department of Neurology, National Taiwan University Hospital, Taipei, ROC
    Brain 126:386-97. 2003
    ..In summary, GBS should be considered a global neuropathy instead of a pure large-fibre neuropathy...
  16. ncbi Autonomic symptoms and diabetic neuropathy: a population-based study
    Phillip A Low
    Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Diabetes Care 27:2942-7. 2004
    ....
  17. pmc Painful diabetic neuropathy is associated with greater autonomic dysfunction than painless diabetic neuropathy
    Rajiv A Gandhi
    Diabetes Research Unit, Royal Hallamshire Hospital, Sheffield, UK
    Diabetes Care 33:1585-90. 2010
    ..This study aimed to investigate the relationship of autonomic neuropathy with painless and painful DPN...
  18. ncbi Diabetic cardiovascular autonomic neuropathy: risk factors, clinical impact and early diagnosis
    Luiz Clemente de Souza Pereira Rolim
    Universidade Federal de Sao Paulo Escola Paulista de Medicina, Sao Paulo, SP, Brasil
    Arq Bras Cardiol 90:e24-31. 2008
    ..However, in advanced cases (severe stage), the only treatment that remains is a symptomatic one. CAN is associated with higher cardiovascular morbidity and mortality rates and poor quality of life in diabetic individuals...
  19. ncbi Migraine and heart rate variability
    Antonio Perciaccante
    Arch Intern Med 167:2264; author reply 2264-5. 2007
  20. ncbi Myasthenia gravis with autoimmune autonomic neuropathy
    S Vernino
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Auton Neurosci 88:187-92. 2001
    ..These observations support a rare but definite clinical association between myasthenia gravis and autonomic failure and strengthen the concept that subacute autonomic neuropathy is an autoimmune disorder...
  21. ncbi Progression of dysautonomia in multiple system atrophy: a prospective study of self-perceived impairment
    M Köllensperger
    Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Eur J Neurol 14:66-72. 2007
    ..This is the first study to investigate self-perceived dysautonomia severity in MSA and its evolution over time. Our data suggest that dysautonomia should be recognized as a key target for therapeutic intervention in MSA...
  22. ncbi Detection of small-fiber neuropathy by sudomotor testing
    Victoria A Low
    Department of Neurology, Mayo Clinic, Guggenheim 811, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 34:57-61. 2006
    ..Sudomotor examination is thus a highly sensitive detection tool in DSFN. Autonomic involvement is mainly distal, and additionally may involve adrenergic and the long cardiovagal fibers...
  23. pmc Effects of cardiac autonomic dysfunction on mortality risk in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial
    Rodica Pop-Busui
    Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA
    Diabetes Care 33:1578-84. 2010
    ....
  24. pmc The ECG vertigo in diabetes and cardiac autonomic neuropathy
    Christina Voulgari
    Department of Propaedeutic and Internal Medicine, Athens University Medical School, Laiko General Hospital, 17 Saint Thomas Street, Athens 11527, Greece
    Exp Diabetes Res 2011:687624. 2011
    ..In this paper, the clinical and research value of the ECG is readdressed in diabetes and in the presence of cardiac autonomic neuropathy...
  25. ncbi Harlequin syndrome--one face of many etiologies
    Gunnar Wasner
    Prince of Wales Medical Research Institute, University of New South Wales, Randwick, Sydney, NSW, Australia
    Nat Clin Pract Neurol 1:54-9. 2005
    ..8 x 1.2 x 1.2 cm (volume 1.1 ml) had been discovered 2 years previously, within the left lobe of an otherwise uncomplicated goiter that had been successfully managed for 20 years. Otherwise, the patient was healthy...
  26. ncbi Autonomic testing: common techniques and clinical applications
    Louis H Weimer
    EMG Laboratory and Clinical Autonomic Laboratory, Neurological Institute of New York, Columbia University Medical Center, New York, NY 10032, USA
    Neurologist 16:215-22. 2010
    ....
  27. ncbi Lateral medullary infarction secondary to vertebral artery dissection presenting as a trigeminal autonomic cephalalgia
    Alberto Villarejo Galende
    Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain
    Headache 44:70-4. 2004
    ..A bilateral vertebral artery dissection was demonstrated. The existence of secondary cases may lead to a better understanding of the pathophysiology of trigeminal autonomic cephalalgias...
  28. ncbi Autonomic dysfunctions in dementia with Lewy bodies
    Yoshihiko Horimoto
    Choju Medical Institute, Fukushimura Hospital, Noyori, Toyohashi, Aichi 441 8124, Japan
    J Neurol 250:530-3. 2003
    ..We found that DLB of all pathological subtypes exhibits some kind and level of autonomic symptoms...
  29. ncbi Comparison between coefficient of R-R interval variation and gastric emptying in type 2 diabetes mellitus patients
    Hideki Asakawa
    Internal Medicine, Suita Municipal Hospital, Osaka, Japan
    J Gastroenterol Hepatol 20:1358-64. 2005
    ..Autonomic neuropathy is a common complication of diabetes mellitus (DM)...
  30. ncbi The use of an isometric handgrip test to show autonomic damage in people with diabetes
    Jerrold Petrofsky
    Department of Physical Therapy, Loma Linda University, Loma Linda, California 92350, USA
    Diabetes Technol Ther 11:361-8. 2009
    ..However, while much has been published on impairment of the autonomic nervous system, much less has been published on the interrelationship between autonomic damage and exercise...
  31. ncbi Squatting, a posture test for studying cardiovascular autonomic neuropathy in diabetes
    J C Philips
    Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, CHU Sart Tilman, 4000 Liege, Belgium
    Diabetes Metab 37:489-96. 2011
    ..The slope, which represents baroreflex sensitivity, is significantly reduced in patients with CAN. This discriminatory index allows study of the natural history of CAN in a large cohort of diabetic patients...
  32. ncbi Pupillographic findings in 39 consecutive cases of harlequin syndrome
    Fion Bremner
    Department of Neuro Ophthalmology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
    J Neuroophthalmol 28:171-7. 2008
    ..Anecdotal reports suggest that some of these patients have abnormal pupils. In this study we set out to systematically investigate autonomic pupil disturbances in an unselected cohort of patients with harlequin syndrome...
  33. pmc Harlequin syndrome in two athletes
    K E Fallon
    Australian Institute of Sport, Belconnen, ACT, Australia
    Br J Sports Med 39:e1. 2005
    ..This condition is most likely to be first noticed in sporting situations...
  34. ncbi Premotor signs and symptoms of multiple system atrophy
    Milica Jecmenica-Lukić
    Clinic of Neurology, School of Medicine, University of Belgrade, Serbia
    Lancet Neurol 11:361-8. 2012
    ..An early and accurate diagnosis is becoming increasingly important as new neuroprotective agents are developed...
  35. ncbi Unnoticed dysautonomic syndrome of the face: Harlequin syndrome
    Nida Tascilar
    Department of Neurology, Zonguldak Karaelmas University Medical Faculty, Zonguldak, Turkey
    Auton Neurosci 137:1-9. 2007
    ..These cases are discussed together with a review of the literature...
  36. ncbi The wide spectrum of clinical manifestations in Sjögren's syndrome-associated neuropathy
    Keiko Mori
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Brain 128:2518-34. 2005
    ....
  37. ncbi Early development of autonomic dysfunction may predict poor prognosis in patients with multiple system atrophy
    Mari Tada
    Department of Neurology, Resource Branch for Brain Disease Research, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8122, Japan
    Arch Neurol 64:256-60. 2007
    ..Multiple system atrophy (MSA) is diverse in clinical phenotype, disease progression, and prognosis. Sudden death is a leading cause of death in patients with MSA...
  38. ncbi Autonomic dysfunction in peripheral nerve disease
    Phillip A Low
    Department of Neurology, Mayo Foundation, 811 Guggenheim, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 27:646-61. 2003
    ..Non-invasive autonomic testing complements clinical and electrophysiological characterization of the autonomic neuropathies...
  39. ncbi Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) or cranial autonomic features (SUNA)--a prospective clinical study of SUNCT and SUNA
    Anna S Cohen
    Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery London, UK
    Brain 129:2746-60. 2006
    ....
  40. ncbi Parasympathetic dysfunction is associated with baroreflex and chemoreflex impairment in streptozotocin-induced diabetes in rats
    Viviane Oliveira Kenne da Silva
    Department of Physiological Sciences, Federal School Foundation of Medical Sciences of Porto Alegre and Unilasalle, RS, Brazil
    Auton Neurosci 131:28-35. 2007
    ....
  41. ncbi Aortic distensibility is reduced in subjects with type 2 diabetes and cardiac autonomic neuropathy
    N Tentolouris
    Athens University Medical School, Laiko Hospital, Athens, Greece
    Eur J Clin Invest 33:1075-83. 2003
    ..Cardiac autonomic neuropathy is common in subjects with diabetes. However, the relationship between the elastic properties of the aorta and autonomic neuropathy has not been studied to date in subjects with type 2 diabetes...
  42. ncbi Autonomic nervous symptoms in primary Sjogren's syndrome
    T Mandl
    Department of Rheumatology, Ing 25 plan 2, Malmo University Hospital, S 205 02 Malmo, Sweden
    Rheumatology (Oxford) 47:914-9. 2008
    ..Therefore, the aims of this study were (i) to assess the presence and severity of various AD symptoms in pSS patients and (ii) to relate AD symptoms to other clinical features of pSS...
  43. ncbi Impaired autonomic function is associated with increased mortality, especially in subjects with diabetes, hypertension, or a history of cardiovascular disease: the Hoorn Study
    J Gerritsen
    Department of Clinical Physics and Informatics, Vrije Universiteit, Amsterdam, The Netherlands
    Diabetes Care 24:1793-8. 2001
    ..Moreover, the results of the present study suggest that cardiac autonomic dysfunction in patients already at risk (diabetes, hypertension, or history of cardiovascular disease) may be especially hazardous...
  44. ncbi Effects of autonomic neuropathy on coronary blood flow in patients with diabetes mellitus
    M F Di Carli
    Department of Internal Medicine, Positron Emission Tomography Center Detroit, MI, USA
    Circulation 100:813-9. 1999
    ..C ardiac sympathetic signals play an important role in the regulation of myocardial perfusion. We hypothesized that sympathetically mediated myocardial blood flow would be impaired in diabetics with autonomic neuropathy...
  45. ncbi Optimal parameters of short-term heart rate spectrogram for routine evaluation of diabetic cardiovascular autonomic neuropathy
    K Howorka
    Department of Biomedical Engineering and Physics, University of Vienna, Austria
    J Auton Nerv Syst 69:164-72. 1998
    ..Cumulative spectral power of total frequency band (LFHF cumpower) can be used for overall description of the degree of cardiac denervation in diabetes while using short-term PSA of HRV...
  46. ncbi Sympathetic dysfunction in type 1 diabetes: association with impaired myocardial blood flow reserve and diastolic dysfunction
    Rodica Pop-Busui
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0678, USA
    J Am Coll Cardiol 44:2368-74. 2004
    ..This study was designed to explore the relationships of early diabetic microangiopathy to alterations of cardiac sympathetic tone and myocardial blood flow (MBF) regulation in subjects with stable type 1 diabetes...
  47. ncbi Assessment of cardiovascular autonomic function
    Roy Freeman
    Anatomic and Peripheral Neerve Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Clin Neurophysiol 117:716-30. 2006
    ....
  48. ncbi Hypoglycemia-associated autonomic failure in diabetes
    P E Cryer
    Division of Endocrinology, Diabetes and Metabolism, General Clinical Research Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 281:E1115-21. 2001
    ....
  49. ncbi Oxidative stress and autonomic nerve function in early type 1 diabetes
    Robert Daniel Hoeldtke
    LSU Medical School, Shreveport, LA, USA
    Clin Auton Res 21:19-28. 2011
    ..Oxidative stress is also present in human diabetes, but its clinical importance is uncertain...
  50. ncbi Neuropathology of Lewy body disorders
    Eniko Kovari
    Department of Psychiatry, HUG Belle Idée, University Hospitals of Geneva, Switzerland
    Brain Res Bull 80:203-10. 2009
    ..The recent progress of neuropathology in this field made it possible to define clinical and neuropathological guidelines for the diagnosis. This review briefly describes the most important data of all Lewy body related disorders...
  51. pmc Hypoglycemia-associated autonomic failure is prevented by opioid receptor blockade
    James Leu
    Department of Medicine, Division of Endocrinology and Metabolism, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    J Clin Endocrinol Metab 94:3372-80. 2009
    ..Repeated hypoglycemia is associated with hypoglycemia-associated autonomic failure (HAAF), a syndrome of defective counterregulation...
  52. ncbi Evaluation of distal symmetric polyneuropathy: the role of autonomic testing, nerve biopsy, and skin biopsy (an evidence-based review)
    J D England
    Louisiana State University Health Sciences Center, Baton Rouge, Louisiana, USA
    Muscle Nerve 39:106-15. 2009
    ..There is a need for additional prospective studies to define more exact guidelines for the evaluation of polyneuropathy...
  53. ncbi Predictive value of cardiac autonomic neuropathy in diabetic patients with or without silent myocardial ischemia
    P Valensi
    Department of Endocrinology, Diabetology, and Nutrition, Jean Verdier Hospital, Bondy, France
    Diabetes Care 24:339-43. 2001
    ..The aim of this study was to determine the predictive value of silent myocardial ischemia (SMI) and cardiac autonomic neuropathy (CAN) in asymptomatic diabetic patients...
  54. ncbi Markers for silent myocardial ischemia in diabetes. Are they helpful?
    E Cosson
    Department of Endocrinology Diabetology Nutrition, Paris Nord University, Jean Verdier Hospital, AP HP, Bondy, France
    Diabetes Metab 31:205-13. 2005
    ..New markers, such as adhesion molecules, Lp(a), inflammation parameters or homocysteine, and endothelium function assessment might be of further help in the future...
  55. ncbi Usefulness of a new indicator test for the diagnosis of peripheral and autonomic neuropathy in patients with diabetes mellitus
    S Liatis
    First Department of Internal Medicine, Athens University Medical School and Diabetes Centre, Laiko General Hospital, Athens, Greece
    Diabet Med 24:1375-80. 2007
    ....
  56. pmc Autonomic neuropathy in Fabry disease: a prospective study using the Autonomic Symptom Profile and cardiovascular autonomic function tests
    Marieke Biegstraaten
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    BMC Neurol 10:38. 2010
    ..The aim of our study was to investigate autonomic symptoms and cardiovascular autonomic function in a large cohort of male and female Fabry patients...
  57. ncbi Cardiac autonomic neuropathy in diabetes mellitus: prevalence, risk factors and utility of corrected QT interval in the ECG for its diagnosis
    J M Pappachan
    Kottayam Medical College, Kottayam, Kerala, South India
    Postgrad Med J 84:205-10. 2008
    ..To study the prevalence and risk factors for cardiac autonomic neuropathy (CAN) and the utility of prolongation of corrected QT interval (QTc) in the ECG to diagnose CAN in patients with diabetes mellitus...
  58. pmc Moisture status of the skin of the feet assessed by the visual test neuropad correlates with foot ulceration in diabetes
    Nicholas Tentolouris
    First Department of Propaedeutic Medicine, Laiko General Hospital, Athens University Medical School, Athens, Greece
    Diabetes Care 33:1112-4. 2010
    ..To examine the association between the moisture status of the skin of the feet with foot ulceration in subjects with diabetes...
  59. ncbi Autonomic activation and pain in response to low-grade mental stress in fibromyalgia and shoulder/neck pain patients
    Kristian Bernhard Nilsen
    Norwegian University of Science and Technology, Department of Neurosciences, N 7489, Trondheim, Norway
    Eur J Pain 11:743-55. 2007
    ..We wanted to examine the relationship between low-grade autonomic activation and stress-related pain in patients with fibromyalgia and localised chronic shoulder/neck pain...
  60. ncbi Autonomic peripheral neuropathy
    Roy Freeman
    Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Lancet 365:1259-70. 2005
    ..Autonomic dysfunction can occur in association with specific infections. The availability of sensitive and reproducible measures of autonomic function has improved physicians' ability to diagnose these disorders...
  61. ncbi Small fiber neuropathy: a common and important clinical disorder
    E Hoitsma
    Department of Clinical Neurophysiology, Maastricht University Hospital, Maastricht, The Netherlands
    J Neurol Sci 227:119-30. 2004
    ..Unless an underlying disease is identified, treatment is usually symptomatic and directed towards alleviation of neuropathic pain...
  62. ncbi Autonomic nervous system dysfunction involving the gastrointestinal and the urinary tracts in primary Sjögren's syndrome
    L Kovacs
    Department of Rheumatology, University of Szeged, Faculty of Medicine, Szeged
    Clin Exp Rheumatol 21:697-703. 2003
    ....
  63. ncbi The effects of static muscular contraction on blood pressure, heart rate, pain ratings and pressure pain thresholds in healthy individuals and patients with fibromyalgia
    Diana Kadetoff
    Section of Clinical Pain Research, Department of Surgical Sciences, Karolinska Institute, Stockholm, Sweden
    Eur J Pain 11:39-47. 2007
    ..No exercise related change in PPTs was seen in either group, most likely due to insufficient exercise intensity, but the contraction induced pain was more pronounced in the FM patients...
  64. ncbi Oesophageal dysmotility, delayed gastric emptying and autonomic neuropathy correlate to disturbed glucose homeostasis
    B Ohlsson
    Department of Clinical Sciences, Gastroenterology Division, Malmo University Hospital, Lund University, Malmo, Sweden
    Diabetologia 49:2010-4. 2006
    ..This study analysed whether oesophageal dysmotility, delayed gastric emptying or autonomic neuropathy affect glucose homeostasis...
  65. pmc The association among autonomic nervous system function, incident diabetes, and intervention arm in the Diabetes Prevention Program
    Mercedes R Carnethon
    Department of Preventive Medicine, Northwestern University, Chicago, Illinois, USA
    Diabetes Care 29:914-9. 2006
    ..2 years...
  66. ncbi [Botulinum toxin in otorhinolaryngology]
    S Rohrbach
    HNO Klinik der Universität Göttingen
    HNO 52:635-41. 2004
    ..Through its anticholinergic effect, botulinum toxin is a suitable therapeutic option for dysfunctions of the muscular and the autonomic nervous system...
  67. ncbi A 14-year prospective study of autonomic nerve function in Type 1 diabetic patients: association with nephropathy
    A Forsén
    Department of Endocrinology, Lund University, Malmo University Hospital, Malmo, Sweden
    Diabet Med 21:852-8. 2004
    ..Prospective studies of autonomic nerve function are rare. We have followed the progression of autonomic dysfunction in relation to nephropathy over 14 years in Type 1 diabetic patients...
  68. ncbi Cardiovascular autonomic dysfunction in primary Sjögren's syndrome
    Laszlo Kovacs
    Department of Rheumatology, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Rheumatology (Oxford) 43:95-9. 2004
    ..To assess the occurrence and clinical significance of a cardiovascular autonomic nervous system dysfunction in primary Sjögren's syndrome (pSS)...
  69. ncbi Sex differences in cardiac and autonomic response to clinical and experimental pain in LBP patients
    Yannick Tousignant-Laflamme
    Universite de Sherbrooke, Faculty of Medicine and Health Sciences, Neurosurgery, 3001, 12e Avenue Nord, Sherbrooke, Que, Canada J1H 5N4
    Eur J Pain 10:603-14. 2006
    ..However, heart rate variability analysis showed greater sympathetic cardiac regulation for men. The sex differences observed in this study call for caution when interpreting HR during pain assessment...
  70. ncbi Autonomic nervous system derangement in fibromyalgia syndrome and related disorders
    H Cohen
    Anxiety and Stress Research Unit, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Isr Med Assoc J 3:755-60. 2001
    ..It raises the potentially important prognostic implications of protracted autonomic dysfunction in patient populations with fibromyalgia and related disorders, especially for cardiovascular morbidity and mortality...
  71. ncbi Changes of gastric emptying rate and gastrin levels are early indicators of autonomic neuropathy in type II diabetic patients
    L Migdalis
    Department of Diabetes, NIMTS Hospital, Athens, Greece
    Clin Auton Res 11:259-63. 2001
    ..These tests should be reserved for patients with symptoms suggestive of disturbed gastric emptying, or for patients with autonomic neuropathy without symptoms of gastroparesis...
  72. ncbi Anderson-Fabry disease: extrarenal, neurologic manifestations
    Edwin H Kolodny
    Neurogenetics Program, Department of Neurology and Pediatrics, New York University School of Medicine, New York, NY 10016, USA
    J Am Soc Nephrol 13:S150-3. 2002
  73. pmc Jugular venous overflow of noradrenaline from the brain: a neurochemical indicator of cerebrovascular sympathetic nerve activity in humans
    David A Mitchell
    Human Neurotransmitter Laboratory, Baker Medical Research Institute, Prahran, Victoria, Australia
    J Physiol 587:2589-97. 2009
    ..We suggest that measurements of transcranial plasma noradrenaline spillover have utility as a method for assessing the sympathetic nerve activity of the cerebral vasculature...
  74. ncbi Heart rate variability in patients with Sjögren's syndrome
    B Tumiati
    Santa Maria Nuova Hospital, Reggio Emilia, Italy
    Clin Rheumatol 19:477-80. 2000
    ....
  75. ncbi Autonomic and orthostatic dysfunction in primary Sjögren's syndrome
    Thomas Mandl
    Departments of Rheumatology and Clinical Physiology, Malmo University Hospital, and the Sjögren s Syndrome Research Centre, Malmo, Sweden
    J Rheumatol 34:1869-74. 2007
    ..Since autonomic nervous signaling is a prerequisite for exocrine secretion we wanted to assess autonomic nervous function in pSS and relate it to diagnostic measures of exocrine function...
  76. ncbi Circadian patterns of heart rate variability, fibrinolytic activity, and hemostatic factors in type I diabetes mellitus with cardiac autonomic neuropathy
    D Aronson
    Division of Cardiology, Beth Israel Deaconess Medical Center, Joslin Diabetes Center, Boston, Massachusetts, USA
    Am J Cardiol 84:449-53. 1999
    ..These abnormalities may attenuate the relative protection from coronary events during the afternoon and nighttime...
  77. ncbi Autonomic neuropathy, I. Clinical features, investigation, pathophysiology, and treatment
    A J McDougall
    Department of Medicine, University of Sydney, Australia
    J Neurol Sci 137:79-88. 1996
    ..Diseases that primarily affect small nerve fibres or cause acute demyelination of small myelinated fibres are most likely to cause autonomic dysfunction. Management includes treating the underlying cause and symptomatic therapy...
  78. ncbi [Botulinum toxin treatment in the head and neck region: current aspects, developments, and problems]
    R Laskawi
    Universitäts HNO Klinik, Robert Koch Strasse 40, 37075, Gottingen, Deutschland
    HNO 55:437-42. 2007
    ..Some of these options will shortly be put into clinical use, while others have to be checked further in clinical studies...
  79. ncbi Autonomic peripheral neuropathy
    Roy Freeman
    Department of Neurology, Harvard Medical School, Center for Autonomic and Peripheral Nerve Disorders, Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, MA 02215, USA
    Neurol Clin 25:277-301. 2007
    ..The features associated with an autonomic neuropathy include impairment of cardiovascular, gastrointestinal, urogenital, thermoregulatory, sudomotor, and pupillomotor autonomic function...
  80. ncbi A potent sorbitol dehydrogenase inhibitor exacerbates sympathetic autonomic neuropathy in rats with streptozotocin-induced diabetes
    Robert E Schmidt
    Department of Pathology and Immunology, Division of Neuropathology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    Exp Neurol 192:407-19. 2005
    ....
  81. ncbi The association between the spatial QRS-T angle with cardiac autonomic neuropathy in subjects with Type 2 diabetes mellitus
    C Voulgari
    1st Department of Propaedeutic and Internal Medicine, Athens University Medical School, Laiko General Hospital, Athens, Greece
    Diabet Med 27:1420-9. 2010
    ..To examine differences in the spatial QRS-T angle in patients with Type 2 diabetes mellitus with and without cardiac autonomic neuropathy...
  82. ncbi Oesophageal motility disorders in type 1 diabetes mellitus and their relation to cardiovascular autonomic neuropathy
    J F Ascaso
    Department of Endocrinology, University of Valencia, Valencia, Spain
    Neurogastroenterol Motil 18:813-22. 2006
    ..05, logistic regression analysis). Increase in simultaneous waves and impaired relaxation of LOS are more frequent in diabetic patients with CVAN...
  83. ncbi Autonomic nervous dysfunction development in patients with primary Sjogren's syndrome: a follow-up study
    Thomas Mandl
    Department of Clinical Sciences, Division of Rheumatology, Malmo University Hospital, S 205 02 Malmo, Sweden
    Rheumatology (Oxford) 49:1101-6. 2010
    ..To investigate autonomic dysfunction (AD) development in patients with primary SS (pSS) and the associations between AD and clinical, inflammatory and serological features of pSS...
  84. pmc Harlequin syndrome with crossed sympathetic deficit of the face and arm
    So Young Moon
    Department of Neurology, College of Medicine, Seoul National University, Seoul National University Bundang Hospital, Seongnam 463 707, Korea
    J Korean Med Sci 20:329-30. 2005
    ..The sympathetic impairment in our patient may lie on a spectrum of pre- and postganglionic autonomic dysfunction, which was observed in Holmes-Adie, Ross, and Guillain-Barre syndromé...
  85. ncbi Autonomic dysfunction and adrenocortical unresponsiveness to ACTH
    G Makari
    Department of Neurology, Medical College of Georgia, Augusta 30912 3760
    J Child Neurol 3:174-6. 1988
    ..These findings suggest progressive parasympathetic denervation as a cause for the adrenocortical abnormality...
  86. ncbi Clonidine for the treatment of supine hypertension and pressure natriuresis in autonomic failure
    Cyndya Shibao
    Division of Clinical Pharmacology, Department of Medicine and Pharmacology, The Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Hypertension 47:522-6. 2006
    ..66; P=0.043). These results are consistent with residual sympathetic tone contributing to supine hypertension in autonomic failure, which can be targeted with clonidine to decrease BP and nocturnal natriuresis...
  87. ncbi Cardiovascular dysautonomia in de novo Parkinson's disease
    Hisayoshi Oka
    Department of Neurology, Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan
    J Neurol Sci 241:59-65. 2006
    ..Clinical symptoms of Parkinson's disease (PD) include not only motor distress, but also autonomic dysfunction...
  88. ncbi Increased pulse-wave velocity in patients with anxiety: implications for autonomic dysfunction
    Vikram Kumar Yeragani
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
    J Psychosom Res 61:25-31. 2006
    ..These findings suggest an important association between decreased vagal and increased sympathetic function, and decreased arterial compliance and possible atherosclerotic changes and increased BP in patients with anxiety...
  89. ncbi Role of heart rate variability in the early diagnosis of diabetic autonomic neuropathy in children
    Massimo Chessa
    Department of Pediatric Cardiology IPSD, San Donato Milanese, Milan, Italy
    Herz 27:785-90. 2002
    ..Several studies found heart rate variability (HRV) to be useful in assessing the dysfunction of the autonomic nervous system in diabetic children and adolescents, but only few HRV parameters were evaluated in most of them...
  90. pmc Autonomic cardiovascular control in methyl-CpG-binding protein 2 (Mecp2) deficient mice
    John M Bissonnette
    Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Auton Neurosci 136:82-9. 2007
    ..Maximum gain was not different. These results do reveal any disturbance of autonomic cardiovascular regulation in the Mecp2 deficient mouse genotype...
  91. pmc Progression and prognosis in pure autonomic failure (PAF): comparison with multiple system atrophy
    N Mabuchi
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Neurol Neurosurg Psychiatry 76:947-52. 2005
    ..To clarify the progression of autonomic symptoms and functional deterioration in pure autonomic failure (PAF), particularly in comparison with multiple system atrophy (MSA)...
  92. ncbi Measurement of autonomic dysregulation in multiple sclerosis
    A Kodounis
    251 General Airforce Hospital of Athens, Aeginition University of Neurology Hospital, 401 General Army Hospital of Athens, Athens, Greece
    Acta Neurol Scand 112:403-8. 2005
    ..Exactly 45.45% of patients exhibited subjective symptoms of autonomic dysfunction and 42.42% of patients had abnormal laboratory tests results...
  93. ncbi Reduced cardiac parasympathetic activity in children with autism
    Xue Ming
    Department of Neuroscience, New Jersey Medical School, UMDNJ, Newark, 90 Bergen Street, DOC 8100, NJ 07103, USA
    Brain Dev 27:509-16. 2005
    ..These results suggest that there is low baseline cardiac parasympathetic activity with evidence of elevated sympathetic tone in children with autism whether or not they have symptoms or signs of autonomic abnormalities...
  94. ncbi Association between cardiovascular autonomic neuropathy and left ventricular hypertrophy in diabetic haemodialysis patients
    Masato Nishimura
    Cardiovascular Division, Toujinkai Hospital, 16 Negoro, Momoyama cho, Fushimi ku, Kyoto 612 8024, Japan
    Nephrol Dial Transplant 19:2532-8. 2004
    ..We investigated whether cardiovascular autonomic neuropathy is associated with left ventricular hypertrophy (LVH) in diabetic haemodialysis patients...
  95. ncbi Effects of water drinking on cardiovascular responses to supine exercise and on orthostatic hypotension after exercise in pure autonomic failure
    A M Humm
    Neurovascular Medicine Unit, Imperial College London at St Mary s Hospital, London, UK
    J Neurol Neurosurg Psychiatry 79:1160-4. 2008
    ..This study assessed the pressor effect of water on the cardiovascular responses to supine exercise and on OH after exercise...
  96. doi Association between heart rate variability and cognitive function in elderly community-dwelling men without dementia: a preliminary report
    Albert C C Yang
    J Am Geriatr Soc 56:958-60. 2008
  97. ncbi Early abnormalities of vascular and cardiac autonomic control in Parkinson's disease without orthostatic hypotension
    Franca Barbic
    Medicina Interna II, Ospedale L Sacco, Universita degli Studi di Milano, Milan, Italy
    Hypertension 49:120-6. 2007
    ..Prompt recognition of sympathetic abnormalities might result in earlier therapeutic intervention, reduced orthostatic intolerance, and increased quality of life...
  98. ncbi Dysautonomia rhinitis: associated otolaryngologic manifestations and characterization based on autonomic function tests
    Mohamed Nasser Elsheikh
    Otolaryngology Department, Faculty of Medicine, Tanta University, Tanta, Egypt
    Acta Otolaryngol 126:1206-12. 2006
    ..The term dysautonomia rhinitis may be used to specify this autonomic-related rhinitis...
  99. ncbi Acetylcholinesterase inhibition in patients with orthostatic intolerance
    Wolfgang Singer
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Neurophysiol 23:476-81. 2006
    ..Our findings support the suggested mechanisms of enhanced sympathetic ganglionic neurotransmission and a vagal shift in cardiac sympathovagal balance. Acetylcholinesterase inhibition could be a new useful concept in the treatment of OI...
  100. ncbi Adrenergic and vagal baroreflex sensitivity in autonomic failure
    Christine Schrezenmaier
    Department of Neurology, Mayo Foundation, Rochester, MN 55905, USA
    Arch Neurol 64:381-6. 2007
    ..Baroreflex sensitivity is widely used to quantify the vagal component of the reflex, but the adrenergic component is not quantifiable in the autonomic laboratory...
  101. ncbi Sympathetic nerve activity and heart rate variability during severe hemorrhagic shock in sheep
    Andriy I Batchinsky
    U S Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Building 3611, Fort Sam Houston, Texas 78234 6315, USA
    Auton Neurosci 136:43-51. 2007
    ..In this study we explored direct and indirect measures of autonomic nervous system function, as well as changes in cardiovascular complexity, during hemorrhagic shock (HS)...

Research Grants66

  1. Chronic nicotine and synaptic transmission in brainstem respiratory neurons
    RALPH FRANK FREGOSI; Fiscal Year: 2013
    ..It is therefore crucial to begin establishing the mechanisms that lead to abnormal development of the brainstem neurons that regulate these critical homeostatic functions. ..
  2. Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNS
    Arnold E Postlethwaite; Fiscal Year: 2010
    ..This grant proposal will study several potential abnormalities of the immune system caused by chronic loss of sleep in the mouse model of human RA and how the sympathetic nervous system contributes to the severe arthritis. ..
  3. Autonomic Rare Diseases Clinical Research Consortium
    DAVID HERLIE ROBERTSON; Fiscal Year: 2013
    ..to join with patient support groups to harness the knowledge and energies of physicians and investigators in the major centers where these patients are cared for, so that they can discover ways to treat and to cure these diseases ..
  4. NERVE RESHAPING FOR IMPROVED ELECTRODE SELECTIVITY
    Dominique M Durand; Fiscal Year: 2013
    ..In particular, peripheal nerve interfaces could provide a complementary approach to brain microelectrodes for the detection and control of neural function. 1 ..
  5. Mentored Patient-Oriented Research Career Development Aw
    Paola Sandroni; Fiscal Year: 2004
    ..Sandroni with the necessary conceptual development, publications track record and investigational tools to effectively compete as an independent investigator in autonomic disorders in future years. ..
  6. AUTONOMIC CONTRIBUTION TO ENERGY METABOLISM IN HUMANS
    Kong Chen; Fiscal Year: 2005
    ..Experiences gained from this project and the didactic training will also help me to develop into an independent investigator in biomedical research. ..
  7. Peripheral Nerve Ischemia
    Phillip Low; Fiscal Year: 2004
    ..We will then define the therapeutic windows and evaluate the mechanisms of production of hypothermic and antioxidant neuroprotection (Specific aim number 2) from reperfusion injury. ..
  8. HYPOGLYCEMIA AND AUTONOMIC NERVOUS SYSTEM FUNCTION
    Roy Freeman; Fiscal Year: 2007
    ..Thus, the broad long term objectives of the proposal are to fully understand the mechanisms and consequences of hypoglycemia associated autonomic failure with the ultimate goal of finding an efficacious treatment. ..
  9. DIABETIC AUTONOMIC NEUROPATHY
    Phillip Low; Fiscal Year: 2001
    ..abstract_text> ..
  10. Conference on the Diagnosis of Multiple System Atrophy
    Sid Gilman; Fiscal Year: 2006
    ..This conference will assist with early diagnosis by developing new guidelines for diagnosis using newly available imaging and neuropathological criteria. [unreadable] [unreadable] [unreadable]..
  11. NEUROPATHOLOGY OF THE AGING SYMPATHETIC NERVOUS SYSTEM
    Robert Schmidt; Fiscal Year: 2006
    ..The results of these experiments should provide insight not only into autonomic dysfunction, but into a variety of pathologic processes in which NAD is a prominent component. ..
  12. Experimental Dysautonomia: Pathogenesis and Treatment
    Steven Vernino; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  13. Cyclooxygenase Pathway and Diabetic Neuropathy
    Rodica Pop Busui; Fiscal Year: 2005
    ..abstract_text> ..
  14. Adenosine and Nitric Oxide Deficiency
    Italo Biaggioni; Fiscal Year: 2004
    ....
  15. Autonomic Nervous System in Chronic Fatigue Syndrome
    Italo Biaggioni; Fiscal Year: 2009
    ....
  16. PHARMACOLOGIC PROBES IN NEURALLY-MEDIATED SYNCOPE
    Italo Biaggioni; Fiscal Year: 2003
    ..These studies will be directly applicable to the evaluation and treatment of patients with these incapacitating disorders. ..
  17. EXPERIMENTAL DIABETIC AUTONOMIC NEUROPATHY
    ROBERT EDWARD SCHMIDT; Fiscal Year: 2010
    ..Thus, we are poised to understand the pathogenesis and develop novel therapies for diabetic autonomic neuropathy. ..
  18. Cytokine-induced depression & the serotonin transporter
    Richard Sloan; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  19. HOSTILITY REDUCTION AND AUTONOMIC CONTROL OF THE HEART
    Richard Sloan; Fiscal Year: 2004
    ....
  20. PSYCHOPHYSIOLOGIC STRESS, EXERCISE AND AUTONOMIC CONTROL
    Richard Sloan; Fiscal Year: 2001
    ..A series of hypotheses will test the impact of aerobic conditioning on autonomic control of the heart, BPV responses to challenge, mood, and BPV throughout the day. ..
  21. VIOLENCE--INTEGRATING SOCIAL AND PHYSIOLOGICAL FACTORS
    Adrian Raine; Fiscal Year: 2003
    ....
  22. Behavioral Ecology and Hostility & Cardiac ANS Control
    Richard Sloan; Fiscal Year: 2007
    ..Thus, we expect to demonstrate how personality traits, in combination with social interactions and behavior throughout the day, drive the risk of CHD through an autonomic mechanism. ..
  23. CARDIOVASCULAR AUTONOMIC CONTROL IN STRESS AND ANXIETY
    Richard Sloan; Fiscal Year: 2002
    ..In this application, 5 experimental tests of this model are proposed. ..
  24. Autonomic Control & Birth Outcomes in Minority Women
    Richard Sloan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  25. DEPRESSION, SLEEP DISORDERS AND CORONARY HEART DISEASE
    Robert Carney; Fiscal Year: 2002
    ....
  26. Cell-free VEE assembly system and alphavirus drug screen
    JAISRI LINGAPPA; Fiscal Year: 2006
    ..The cell-free VEE assembly system offer a safe and low cost approach to understanding the mechanism of VEE capsid formation and to screen for agents active against alphaviruses that have potential as bioterrorism agents. ..
  27. The Efficacy of TUMT and Neoadjuvant Finasteride for BPH
    Kevin McVary; Fiscal Year: 2005
    ..We are proposing a 3-arm, placebo/sham controlled, randomized clinical trial using changes in symptoms as the primary ..
  28. Determinants in Recovery from TBI in Children 0-3
    James Blackman; Fiscal Year: 2005
    ..This project will be far more comprehensive than previous studies of brain injury in infants and toddlers and will explore novel hypotheses regarding genetic determinants of outcome and markers of neuronal injury in young children. ..
  29. Hindbrain Actions of Leptin
    Gerlinda E Hermann; Fiscal Year: 2011
    ..Clearly, a better understanding of the control of energy expenditure should be crucial to the control of obesity and is of critical scientific, clinical and societal importance. ..
  30. Omega-3 for Depression and Other Cardiac Risk Factors
    Robert Carney; Fiscal Year: 2008
    ..abstract_text> ..
  31. Detecting Endothelial Dysfunction in Renal Failure
    Julian Stewart; Fiscal Year: 2007
    ..These data will form the basis of future noninvasive prognostic testing and treatment of patients at risk for ECD and can provide a means to follow treatment modalities. [unreadable] [unreadable] [unreadable]..
  32. Peripheral and Central Mechanism of Pain in Patients with Fibromyalgia
    ROLAND M STAUD; Fiscal Year: 2010
    ..Either way, we will provide evidence that will characterize the role of local anesthesia, placebo analgesia, or both. Thus patients with FM and other similar pain syndromes may strongly benefit from the results of our study. ..
  33. Immune reactivity to synapsin in the neuropathy and ataxia of celiac disease
    Armin Alaedini; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  34. Inhomogeneous Sympathetic Innervation in IHD
    JAMES FALLAVOLLITA; Fiscal Year: 2008
    ..Therefore, these studies will translate basic observations in animals to clinical pathophysiology in humans and identify novel substrate factors that contribute to the risk of SD in chronic ischemic heart disease. ..
  35. Oxidative Stress and Nerve Pathology in Diabetes
    Andrew Mizisin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  36. Abdominal Symptom Phenotypes: Pathways to New Biomarkers
    Robert Shulman; Fiscal Year: 2010
    ..New biomarkers (video capsule endoscopy, lymphocyte activation/cytokine diffuse noxious inhibitory control testing) will be used with newly recruited IBS and control subjects. ..
  37. Canine Multiple System Degeneration: A Novel Animal Model of Parkinsonism
    DENNIS O BRIEN; Fiscal Year: 2008
    ..This research will develop a novel animal model of the disease which can be used to test theories about the cause and develop new therapies. [unreadable] [unreadable] [unreadable]..
  38. Carbidopa for the treatment of nausea and vomiting in familial dysautonomiaIND #
    Horacio Kaufmann; Fiscal Year: 2010
    ..Their long-term goal is to treat nausea effectively and without side effects, a therapeutic intervention that will markedly improve the quality of life of patients with FD. ..
  39. BEHAVIORAL AND IMMUNOLOGICAL FACTORS IN CORONARY DISEASE
    Willem Kop; Fiscal Year: 2005
    ....
  40. Outcome Measures in Idiopathic Intracranial Hypertension
    Deborah Friedman; Fiscal Year: 2008
    ..Acquire the training, mentoring and experience necessary to conduct independent, funded clinical research in ophthalmologic and neurological disorders Obtain a Masters Degree in Public Health/Clinical Investigator track ..
  41. Distress, Fish Oil, Inflammation, and Heart Disease
    Matthew Muldoon; Fiscal Year: 2006
    ..Results of the study could redirect current conceptualizations of the relationship between psychological factors and CHD risk, and lead to randomized clinical trials testing new interventions. ..
  42. CHOLESTEROL REDUCTION EFFECTS ON BEHAVIOR
    Matthew Muldoon; Fiscal Year: 2001
    ..The use of two treatment intensities will permit examination of the dose-response relationship between the degree of cholesterol lowering and cognitive performance. ..
  43. OTOLITH INFLUENCES ON SYMPATHETIC ACTIVITY
    Horacio Kaufmann; Fiscal Year: 2004
    ..abstract_text> ..
  44. Circulatory Dysfunction in Chronic Fatigue Syndrome
    Julian Stewart; Fiscal Year: 2004
    ....
  45. REGULATION OF PROSTATE GROWTH BY NEURAL FACTORS
    Kevin McVary; Fiscal Year: 2001
    ..Using this model allows one to explore the limits of understanding prostatic neuroregulation, to explore neurotrophic influences on exocrine gland development, and to possibly uncover novel methods to influence prostate disease. ..
  46. CHRONIC LIFE STRESS AND INCIDENT ASTHMA IN ADULT WOMEN
    Rosalind Wright; Fiscal Year: 2003
    ..To our knowledge, this would be the first large-scale (N=64,000) longitudinal study of the association between a specific chronic life stressor (i.e., violence) and the incidence of asthma in adult women. ..
  47. NEURAL MECHANISMS OF VENTRICULAR ELECTRICAL REMODELING
    Philip Adamson; Fiscal Year: 2003
    ..These clinically applicable interventions may modify the natural history of diseases, such as heart failure, characterized by ventricular electrical remodeling leading to a high risk for lethal arrhythmias. ..
  48. MITOCHONDRIAL DNA ANALYSIS IN CYCLIC VOMITING SYNDROME
    Richard Boles; Fiscal Year: 2002
    ..An extensive amount of clinical and laboratory data will be collected in all patients, allowing for the comparison of CVS sufferers with and without mtDNA mutations. ..
  49. N O S AND NEUROPATHIC AND ENDOTHELIAL INDUCED ED
    Kevin McVary; Fiscal Year: 2002
    ..Results of this research will aid in the understanding of how diabetic neuropathy contributes to sexual dysfunction and elucidate possible mechanisms to prevent them. ..
  50. OPIOID EFFECTS ON HYPOTHALAMIC NEURONAL EXCITABILITY
    Martin Kelly; Fiscal Year: 2002
    ....
  51. Bionic Baroreflex System for Blood Pressure Control
    Andre Diedrich; Fiscal Year: 2002
    ..A Phase II study would involve studies in animals and in patients with MSA to determine the long-term efficacy of the bionic baroreflex system in improving blood pressure control...
  52. Women's Health Complementary and Alternative Therapies
    Margaret Heitkemper; Fiscal Year: 2004
    ..abstract_text> ..
  53. ANGIOTENSIN AND CENTRAL NEUROHUMORAL ACTIVATION IN CHF
    Robert Felder; Fiscal Year: 2005
    ..This work will provide new information concerning the role of the central nervous system in the pathophysiology of CHF and will draw attention to the possibility of CNS directed drug therapy for heart failure. ..
  54. Perfusion MRI After Donepezil in Lewy Body Dementia
    Tamara Fong; Fiscal Year: 2005
    ..The second phase will be an open labeled, prospective study to assess the chronic effects of ChEI administered over a period of three months. ..
  55. Thrombin and CNS: Gastric Dysfunction after Head Trauma
    Gerlinda Hermann; Fiscal Year: 2006
    ..e., via an R01 funding program). ..
  56. VISUAL INTERVENTIONS TO IMPROVE ALZHEIMER COGNITION
    Alice Cronin Golomb; Fiscal Year: 2004
    ....
  57. Angiotensin Receptors in Central Osmonsensitivity
    Mariana Morris; Fiscal Year: 2005
    ..abstract_text> ..
  58. Conduct Disorder and Depression in Childhood
    Theodore Beauchaine; Fiscal Year: 2006
    ..Findings obtained should further our understanding of the autonomic substrates of CD, depression, and their comorbidity, and may have differential treatment implications for depressed probands who do and do not present with comorbid CD. ..
  59. BRADYKININ IN ENTERIC NEUROIMMUNE COMMUNICATION
    JACKIE WOOD; Fiscal Year: 2005
    ..The overall goal of the study is to better understand the role of bradykinin in motility disturbances, diarrhea, abdominal pain and inflammation. ..
  60. Heart Rate Variability in Mecp2 Deficient Mice
    JOHN BISSONNETTE; Fiscal Year: 2005
    ..These studies will contribute to the understanding of depressed parasympathetic activity in Rett syndrome. ..
  61. ANORECTAL MANIFESTATIONS OF FEMALE PELVIC FLOOR DISORDER
    Adil Bharucha; Fiscal Year: 2002
    ..abstract_text> ..
  62. Organizations, Work Environment, and Quality of Care
    Nicholas Warren; Fiscal Year: 2003
    ..The study will use results to develop site-specific intervention strategies and to disseminate this information to a wider audience. ..
  63. NEURAL MECHANISMS OF LONG-TERM CARDIOVASCULAR CONTROL
    John Osborn; Fiscal Year: 2007
    ..Taken together, this integrative physiological approach will advance our understanding of the neural mechanisms for long-term control of arterial pressure and pathogenesis of neurogenic hypertension. [unreadable] [unreadable]..
  64. Epidemiology and Mechanisms of Fecal Incontinence
    Adil Bharucha; Fiscal Year: 2005
    ..abstract_text> ..
  65. Long-Term Neural Determinants of Cardiovascular Diseases
    John Osborn; Fiscal Year: 2009
    ..abstract_text> ..
  66. Integrating CAM: Nursing Emphasis
    Margaret Heitkemper; Fiscal Year: 2006
    ..abstract_text> ..