guillain barre syndrome

Summary

Summary: An acute inflammatory autoimmune neuritis caused by T cell- mediated cellular immune response directed towards peripheral myelin. Demyelination occurs in peripheral nerves and nerve roots. The process is often preceded by a viral or bacterial infection, surgery, immunization, lymphoma, or exposure to toxins. Common clinical manifestations include progressive weakness, loss of sensation, and loss of deep tendon reflexes. Weakness of respiratory muscles and autonomic dysfunction may occur. (From Adams et al., Principles of Neurology, 6th ed, pp1312-1314)

Top Publications

  1. ncbi A clinical prognostic scoring system for Guillain-Barré syndrome
    Rinske van Koningsveld
    Department of Neurology, Erasmus MC, Rotterdam, Netherlands
    Lancet Neurol 6:589-94. 2007
  2. ncbi HIV-associated Guillain-Barré syndrome
    Thomas H Brannagan
    Department of Neurology, Weill Medical College of Cornell University, Peripheral Neuropathy Center, 635 Madison Avenue, Suite 400, New York, NY 10022, USA
    J Neurol Sci 208:39-42. 2003
  3. ncbi Guillain-Barré syndrome
    Richard A C Hughes
    Department of Clinical Neuroscience, King s College London School of Medicine, Guy s Hospital, UK
    Lancet 366:1653-66. 2005
  4. ncbi West Nile virus infection: a new acute paralytic illness
    L E Jeha
    Department of Neurology, The Cleveland Clinic Foundation, OH 44195, USA
    Neurology 61:55-9. 2003
  5. ncbi Antibodies against gangliosides: a link between preceding infection and immunopathogenesis of Guillain-Barré syndrome
    Beatrix Schwerer
    Department of Neuroimmunology, Brain Research Institute, University of Vienna, Spitalgasse 4, A 1090 Vienna, Austria
    Microbes Infect 4:373-84. 2002
  6. ncbi Infectious origins of, and molecular mimicry in, Guillain-Barré and Fisher syndromes
    N Yuki
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    Lancet Infect Dis 1:29-37. 2001
  7. pmc Structural characterization of Campylobacter jejuni lipooligosaccharide outer cores associated with Guillain-Barre and Miller Fisher syndromes
    Peggy C R Godschalk
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Infect Immun 75:1245-54. 2007
  8. ncbi Preceding infections, immune factors, and outcome in Guillain-Barré syndrome
    R D Hadden
    Department of Neuroimmunology, Guy s, King s and St Thomas School of Medicine, Swan, London, UK
    Neurology 56:758-65. 2001
  9. ncbi Comprehensive analysis of bacterial risk factors for the development of Guillain-Barre syndrome after Campylobacter jejuni enteritis
    Michiaki Koga
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    J Infect Dis 193:547-55. 2006
  10. ncbi Bilateral optic neuritis and Guillain-Barré syndrome following an acute Mycoplasma pneumoniae infection
    Ricardo C Ginestal
    J Neurol 251:767-8. 2004

Detail Information

Publications232 found, 100 shown here

  1. ncbi A clinical prognostic scoring system for Guillain-Barré syndrome
    Rinske van Koningsveld
    Department of Neurology, Erasmus MC, Rotterdam, Netherlands
    Lancet Neurol 6:589-94. 2007
    ..We aimed to develop and validate a scoring system based on clinical characteristics in the acute phase of GBS to predict outcome at 6 months...
  2. ncbi HIV-associated Guillain-Barré syndrome
    Thomas H Brannagan
    Department of Neurology, Weill Medical College of Cornell University, Peripheral Neuropathy Center, 635 Madison Avenue, Suite 400, New York, NY 10022, USA
    J Neurol Sci 208:39-42. 2003
    ..A mild cerebrospinal fluid (CSF) pleocytosis in GBS suggests HIV infection, but is frequently absent. Compared to HIV-negative people, HIV-GBS may be associated with more frequent recurrent episodes or the development of CIDP...
  3. ncbi Guillain-Barré syndrome
    Richard A C Hughes
    Department of Clinical Neuroscience, King s College London School of Medicine, Guy s Hospital, UK
    Lancet 366:1653-66. 2005
    ..Further research is needed to discover treatments to prevent 20% of patients from being left with persistent and significant disability...
  4. ncbi West Nile virus infection: a new acute paralytic illness
    L E Jeha
    Department of Neurology, The Cleveland Clinic Foundation, OH 44195, USA
    Neurology 61:55-9. 2003
    ..To determine the clinical, laboratory, electrodiagnostic, radiologic, and pathologic characteristics that define the spectrum of CNS disease caused by West Nile virus (WNV) infection...
  5. ncbi Antibodies against gangliosides: a link between preceding infection and immunopathogenesis of Guillain-Barré syndrome
    Beatrix Schwerer
    Department of Neuroimmunology, Brain Research Institute, University of Vienna, Spitalgasse 4, A 1090 Vienna, Austria
    Microbes Infect 4:373-84. 2002
    ..Thus, antibodies against gangliosides may link C. jejuni infection with the precipitation of neurological disease...
  6. ncbi Infectious origins of, and molecular mimicry in, Guillain-Barré and Fisher syndromes
    N Yuki
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    Lancet Infect Dis 1:29-37. 2001
    ..Some patients develop FS after C jejuni infection, and the lipopolysaccharide present bears the GQ1b epitope. Molecular mimicry is a possible cause of GBS and FS...
  7. pmc Structural characterization of Campylobacter jejuni lipooligosaccharide outer cores associated with Guillain-Barre and Miller Fisher syndromes
    Peggy C R Godschalk
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Infect Immun 75:1245-54. 2007
    ..jejuni-related GBS. However, our findings suggest that in some cases, other mechanisms may play a role. Further examination of the disease etiology in these patients is mandatory...
  8. ncbi Preceding infections, immune factors, and outcome in Guillain-Barré syndrome
    R D Hadden
    Department of Neuroimmunology, Guy s, King s and St Thomas School of Medicine, Swan, London, UK
    Neurology 56:758-65. 2001
    ..To test the hypothesis that different preceding infections influence the neurophysiologic classification and clinical features of Guillain-Barré syndrome (GBS)...
  9. ncbi Comprehensive analysis of bacterial risk factors for the development of Guillain-Barre syndrome after Campylobacter jejuni enteritis
    Michiaki Koga
    Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
    J Infect Dis 193:547-55. 2006
    ..Guillain-Barre syndrome (GBS), a postinfectious autoimmune-mediated neuropathy, is a serious complication after Campylobacter jejuni enteritis...
  10. ncbi Bilateral optic neuritis and Guillain-Barré syndrome following an acute Mycoplasma pneumoniae infection
    Ricardo C Ginestal
    J Neurol 251:767-8. 2004
  11. ncbi Clinical features, pathogenesis, and treatment of Guillain-Barré syndrome
    Pieter A van Doorn
    Department of Neurology, Erasmus Medical Centre, Rotterdam, Netherlands
    Lancet Neurol 7:939-50. 2008
    ..Advances in prognostic modelling have resulted in the development of a new and simple prognostic outcome scale that might also help to guide new treatment options, particularly in patients with GBS who have a poor prognosis...
  12. ncbi Patterns of Guillain-Barre syndrome in children: results from a Mexican population
    I Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, 4th Floor Gates Building, Philadelphia, PA 19104 4283, USA
    Neurology 69:1665-71. 2007
    ..Previous clinical studies suggested that AMAN also occurs in Mexican children. The purpose of this study was to describe the subtypes of GBS in children from Mexico City...
  13. ncbi Incidence and clinical features of acute inflammatory polyradiculoneuropathy in Lombardy, Italy, 1996
    Graziella Bogliun
    Dipartimento di Scienze Neurologiche, Università Bicocca, Monza, Italy
    Acta Neurol Scand 110:100-6. 2004
    ..To assess the annual incidence of typical Guillain-Barré syndrome (GBS) and its main variants (atypical GBS) in a well-defined population from a large area...
  14. ncbi Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in Guillain-Barré syndrome
    C W Ang
    Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
    J Neuroimmunol 130:179-83. 2002
    ..Anti-GalC antibodies cross-reacted with MP antigen. In conclusion, anti-GalC antibodies in GBS patients may be induced by molecular mimicry with MP...
  15. ncbi The comparative evaluation of gabapentin and carbamazepine for pain management in Guillain-Barré syndrome patients in the intensive care unit
    Chandra Kant Pandey
    Department of Anaesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    Anesth Analg 101:220-5, table of contents. 2005
    ..05). We conclude that gabapentin is more effective than carbamazepine for decreasing pain and fentanyl consumption...
  16. ncbi HLA class II alleles are not a general susceptibility factor in Guillain-Barré syndrome
    K Geleijns
    Department of Neurology, Erasmus Medical Center, PO Box 1738, Rm Ee 2230, 3000 DR Rotterdam, The Netherlands
    Neurology 64:44-9. 2005
    ..To assess whether human leukocyte antigen (HLA)-DRB1 and HLA-DQB1 alleles confer susceptibility to Guillain-Barre syndrome (GBS) or are related to specific clinical or serologic subgroups of GBS...
  17. ncbi Gabapentin for the treatment of pain in guillain-barré syndrome: a double-blinded, placebo-controlled, crossover study
    Chandra K Pandey
    Department of Anaesthesiology and Critical Care Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Anesth Analg 95:1719-23, table of contents. 2002
    ..11 +/- 21.39 to 65.53 +/- 16.17 [ micro g]) in comparison to the placebo therapy period (319.44 +/- 25.08 to 316.67 +/- 24.25 [ micro g]) (P < 0.001)...
  18. pmc Ganglioside molecular mimicry and its pathological roles in Guillain-Barré syndrome and related diseases
    Robert K Yu
    Institute of Molecular Medicine and Genetics and Institute of Neuroscience, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Infect Immun 74:6517-27. 2006
  19. ncbi Carbamezapine for pain management in Guillain-Barré syndrome patients in the intensive care unit
    M Tripathi
    Department of Anaesthesiology and Critical Care Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Crit Care Med 28:655-8. 2000
    ..To evaluate carbamezapine (CBZ) for neuritic pain relief in Guillain-Barré syndrome (GBS) patients in the intensive care unit (ICU)...
  20. ncbi Incidence of Guillain-Barré syndrome following infection with Campylobacter jejuni
    N McCarthy
    Swedish Institute for Infectious Disease Control, SE 171 82, Solna, Sweden
    Am J Epidemiol 153:610-4. 2001
    ..jejuni infection. The risk of developing GBS during the 2 months following a symptomatic episode of C. jejuni infection is approximately 100 times higher than the risk in the general population...
  21. pmc Structure of Campylobacter jejuni lipopolysaccharides determines antiganglioside specificity and clinical features of Guillain-Barré and Miller Fisher patients
    C W Ang
    Department of Neurology, Erasmus University Academic Hospital Dijkzigt Rotterdam, Rotterdam, The Netherlands
    Infect Immun 70:1202-8. 2002
    ..This study provides additional evidence for the hypothesis that the LPS fraction determines the antiganglioside specificity and clinical features in post-Campylobacter neuropathy patients...
  22. pmc Carbohydrate mimicry between human ganglioside GM1 and Campylobacter jejuni lipooligosaccharide causes Guillain-Barre syndrome
    Nobuhiro Yuki
    Department of Neurology, Institute for Medical Science, Dokkyo University School of Medicine, Shimotsuga, Tochigi 321 0293, Japan
    Proc Natl Acad Sci U S A 101:11404-9. 2004
    ..These findings show that carbohydrate mimicry is an important cause of autoimmune neuropathy...
  23. ncbi Campylobacter gene polymorphism as a determinant of clinical features of Guillain-Barré syndrome
    M Koga
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Neurology 65:1376-81. 2005
    ..A C jejuni gene, cst-II, involved in the biosynthesis of ganglioside-like lipo-oligosaccharide, shows a polymorphism (Asn/Thr51) that affects ganglioside epitopes...
  24. pmc Sequence typing confirms that Campylobacter jejuni strains associated with Guillain-Barré and Miller-Fisher syndromes are of diverse genetic lineage, serotype, and flagella type
    K E Dingle
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, OX1 3FY, United Kingdom
    J Clin Microbiol 39:3346-9. 2001
    ..These 4 isolates probably represented the Penner serotype 19 lineage, which has been proposed to have an association with GBS...
  25. pmc Comparison of Campylobacter jejuni lipooligosaccharide biosynthesis loci from a variety of sources
    Craig T Parker
    Produce Safety and Microbiology Unit, WRRC, USDA, ARS, 800 Buchanan St, Albany, CA 94710, USA
    J Clin Microbiol 43:2771-81. 2005
    ..Analysis of the LOS biosynthesis genes by PCR assays can be used for typing C. jejuni and offers the advantage of inferring potential LOS structures...
  26. ncbi Comparative proteomics analysis of cerebrospinal fluid of patients with Guillain-Barré syndrome
    Yin Rong Yang
    Institute of Biochemistry and Molecular Biology, School of Medicine, Shandong University, 44 Wenhuaxi Road, Jinan, Shandong, P R China
    Cell Mol Neurobiol 28:737-44. 2008
    ..These identified proteins may be involved in the pathophysiological process of GBS and call for further studying the role of these proteins in the pathogenesis of the disease...
  27. ncbi Mild forms of Guillain-Barré syndrome in an epidemiologic survey in The Netherlands
    R van Koningsveld
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 54:620-5. 2000
    ....
  28. ncbi Carbohydrate mimicry: a new paradigm of autoimmune diseases
    Nobuhiro Yuki
    Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Curr Opin Immunol 17:577-82. 2005
    ..This new concept that carbohydrate mimicry can cause an autoimmune disease provides a clue to inducing the resolution of pathogenesis of other immune-mediated diseases...
  29. ncbi The occurrence of Guillain-Barre syndrome within families
    K Geleijns
    Department of Neurology, Room Ee 2230, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Neurology 63:1747-50. 2004
    ..The authors observed an earlier onset of GBS in successive generations. The occurrence of GBS within families suggests a role for genetic factors in the pathogenesis of GBS...
  30. pmc Molecular characterization of Campylobacter jejuni from patients with Guillain-Barré and Miller Fisher syndromes
    H P Endtz
    Departments of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Clin Microbiol 38:2297-301. 2000
    ..Therefore, further characterization of GBS- or MFS-related C. jejuni should target the genes involved in the synthesis of LPS and the incorporation of sialic acid...
  31. pmc Antiganglioside antibodies and their pathophysiological effects on Guillain-Barré syndrome and related disorders--a review
    Kenichi Kaida
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Glycobiology 19:676-92. 2009
    ..While GBS is not considered a genetic disease, host factors, particularly human lymphocyte antigen type, appear to have a role in the pathogenesis of GBS following C. jejuni infection...
  32. ncbi Chronic effects of Campylobacter infection
    Irving Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 4th Floor Gates Building, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Microbes Infect 4:399-403. 2002
    ..While little is known about reactive arthritis following Campylobacter infection, our knowledge on the pathogenesis of Campylobacter-induced GBS is expanding rapidly and is summarized in this review...
  33. pmc Comparison of Campylobacter jejuni isolates implicated in Guillain-Barré syndrome and strains that cause enteritis by a DNA microarray
    Edward E Leonard
    Department of Microbiology and Immunology, Stanford University, Stanford, California 94305, USA
    Infect Immun 72:1199-203. 2004
    ..We found that specific GBS genes or regions were not identified, and microarray analysis confirmed significant genomic heterogeneity among the isolates...
  34. ncbi Guillain-Barre syndrome after vaccination in United States a report from the CDC/FDA Vaccine Adverse Event Reporting System
    Nizar Souayah
    Epidemiological and Outcomes Research Division, Zeenat Qureshi Stroke Research Center, Department of Medicine, University of Medicine and Dentistry of New Jersey, 90 Bergen Street, DOC 8100, Newark, NJ 07103, United States
    Vaccine 25:5253-5. 2007
    ..We conclude that vaccines other than influenza vaccine can be associated with GBS...
  35. ncbi Guillain-Barré syndrome in southern Taiwan: clinical features, prognostic factors and therapeutic outcomes
    B C Cheng
    Department of Medicine, Chang Gung Memorial Hospital Kaohsiung, Kaohsiung, Taiwan
    Eur J Neurol 10:655-62. 2003
    ..Therefore, early diagnosis, choice of appropriate treatment, and preventing complications during acute stages are essential to maximize the potential for survival...
  36. pmc Comparative genomic analysis of Campylobacter jejuni associated with Guillain-Barré and Miller Fisher syndromes: neuropathogenic and enteritis-associated isolates can share high levels of genomic similarity
    Eduardo N Taboada
    Institute for Biological Sciences, National Research Council, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada
    BMC Genomics 8:359. 2007
    ..jejuni factors associated with GBS/MFS to date and has allowed us to analyze the genetic background of neuropathogenic C. jejuni strains with an unprecedented level of resolution...
  37. ncbi Guillain-Barré syndrome
    Ted M Burns
    Department of Neurology, University of Virginia, PO Box800394, Charlottesville, VA 22908, USA
    Semin Neurol 28:152-67. 2008
    ..Intravenous immunoglobulin and plasma exchange are efficacious treatments. Supportive care during and following hospitalization is also crucial...
  38. ncbi Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms
    Nina M van Sorge
    Department of Neurology G03 228, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Neuroimmunol 162:157-64. 2005
    ..Results suggest that Fc gammaRIII genotypes may represent mild disease-modifying factors in GBS...
  39. ncbi Distinct pattern of age-specific incidence of Guillain-Barré syndrome in Harbin, China
    Qi Cheng
    Division of Neurology, Huddinge University Hospital, Sweden
    J Neurol 249:25-32. 2002
    ..Possible explanations for the distinct pattern of age-specific incidence of GBS are discussed. Further studies are needed...
  40. ncbi Carbohydrate mimicry of Campylobacter jejuni lipooligosaccharide is critical for the induction of anti-GM1 antibody and neuropathy
    Xiao Mei Shu
    Pediatric Research Institute, Children s Hospital Chongqing, Chongqing Medical College, People s Republic of China
    Muscle Nerve 33:225-31. 2006
    ..These results indicate that ganglioside-mimicry structures in C. jejuni LOS are necessary for induction of antiganglioside antibody response and neuropathy...
  41. ncbi A case of Guillain-Barré syndrome following a family outbreak of Campylobacter jejuni enteritis
    C W Ang
    Department of Neurology, Erasmus University Rotterdam, P O Box 1738, 3000 DR, Rotterdam, The Netherlands
    J Neuroimmunol 111:229-33. 2000
    ..Ganglioside mimicry alone is necessary but not sufficient for the induction of anti-ganglioside antibodies. Other susceptibility factors are required to induce an anti-neural immune response...
  42. ncbi Interleukin-18 is induced in acute inflammatory demyelinating polyneuropathy
    S Jander
    Department of Neurology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    J Neuroimmunol 114:253-8. 2001
    ..42+/-7 pg/ml, P<0.001). Our data implicate the Th1-inducing cytokine IL-18 in the pathogenesis of acute immune-mediated PNS demyelination...
  43. ncbi Acute axonal polyneuropathy with predominant proximal involvement: an uncommon neurological complication of bariatric surgery
    Flavia Costa Nunes Machado
    Department of Clinical Neurophysiology, Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil
    Arq Neuropsiquiatr 64:609-12. 2006
    ..We discuss the importance of nutritional follow-up and the eventual indication of routine vitamin supplementation in these patients...
  44. ncbi The morbidity and outcome of patients with Guillain-Barré syndrome admitted to the intensive care unit
    Rajat Dhar
    Neurology Neurosurgery Intensive Care Unit, Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri 63110, United States
    J Neurol Sci 264:121-8. 2008
    ..One third of patients with Guillain-Barré syndrome (GBS) require admission to the intensive care unit (ICU), associated with significant risk of morbidity, mortality, and incomplete recovery...
  45. ncbi Haemophilus influenzae infection and Guillain-Barré syndrome
    M Mori
    Department of Neurology, Chiba University School of Medicine, Chiba, Japan
    Brain 123:2171-8. 2000
    ..influenzae in the Japanese population. A particular strain of non-typable H. influenzae has a ganglioside GM1-like structure and elicits axonal Guillain-Barré syndrome similar to C. jejuni-related Guillain-Barré syndrome...
  46. ncbi Incidence of Guillain-Barré syndrome among patients with Campylobacter infection: a general practice research database study
    Clarence C Tam
    Infectious Disease Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom
    J Infect Dis 194:95-7. 2006
    ..17/1000 person-years, a rate 77 times greater than that in the general population. The probability that an individual who develops Campylobacter enteritis will also develop GBS during the subsequent 2-month period is <2/10,000...
  47. ncbi No association between immunization and Guillain-Barré syndrome in the United Kingdom, 1992 to 2000
    Richard A Hughes
    Department of Clinical Neuroscience, King s College London School of Medicine, Guy s Campus, London, England
    Arch Intern Med 166:1301-4. 2006
    ..Our goal was to determine whether immunization is associated with the incidence of Guillain-Barré syndrome (GBS)...
  48. pmc T cell reactivity to P0, P2, PMP-22, and myelin basic protein in patients with Guillain-Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy
    P A Csurhes
    Neuroimmunology Research Centre, School of Medicine, The University of Queensland, Brisbane, Australia
    J Neurol Neurosurg Psychiatry 76:1431-9. 2005
    ....
  49. ncbi Physical training and fatigue, fitness, and quality of life in Guillain-Barré syndrome and CIDP
    M P J Garssen
    Department of Neurology, Erasmus Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Neurology 63:2393-5. 2004
    ..Training seemed well tolerated, and self-reported fatigue scores decreased 20% (p = 0.001). Physical fitness, functional outcome, and quality of life were improved...
  50. pmc Management of inflammatory neuropathies
    Robert D M Hadden
    West London Neurosciences Centre, Charing Cross Hospital, London, UK
    J Neurol Neurosurg Psychiatry 74:ii9-ii14. 2003
  51. ncbi Nerve conduction studies in relation to residual fatigue in Guillain-Barré syndrome
    Marcel P J Garssen
    Department of Neurology, Erasmus Medical Center Rotterdam, 1738, 3000, DR Rotterdam, The Netherlands
    J Neurol 253:851-6. 2006
    ..This study demonstrates that fatigue in GBS is not explained by residual nerve dysfunction, using conventional NC measurements...
  52. ncbi Studies of HLA associations in male and female patients with Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)
    Pamela A McCombe
    Neuroimmunology Research Centre, School of Medicine, The University of Queensland, Brisbane, Australia
    J Neuroimmunol 180:172-7. 2006
    ..This suggests that sex-related factors may interact with the risk associated with carriage of HLA-DR2 for development of CIDP...
  53. pmc The crucial role of Campylobacter jejuni genes in anti-ganglioside antibody induction in Guillain-Barre syndrome
    Peggy C R Godschalk
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Clin Invest 114:1659-65. 2004
    ..We demonstrate, for the first time, to our knowledge, that specific bacterial genes are crucial for the induction of anti-ganglioside antibodies...
  54. pmc Identification of DNA sequence variation in Campylobacter jejuni strains associated with the Guillain-Barré syndrome by high-throughput AFLP analysis
    Peggy C R Godschalk
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Dr, Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    BMC Microbiol 6:32. 2006
    ..This study describes a new C. jejuni-specific high-throughput AFLP (htAFLP) approach for detection and identification of DNA polymorphism, in general, and of putative GBS/MFS-markers, in particular...
  55. pmc Amantadine for treatment of fatigue in Guillain-Barre syndrome: a randomised, double blind, placebo controlled, crossover trial
    M P J Garssen
    Department of Neurology, Erasmus Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 77:61-5. 2006
    ..In this trial, the effect of amantadine on severe fatigue related to GBS was studied...
  56. pmc Exchange of lipooligosaccharide synthesis genes creates potential Guillain-Barre syndrome-inducible strains of Campylobacter jejuni
    Vongsavanh Phongsisay
    Biotechnology and Environmental Biology, School of Applied Sciences, Bundoora, 3083, RMIT University, Melbourne, Victoria, Australia
    Infect Immun 74:1368-72. 2006
    ....
  57. ncbi AMSAN variant of Guillain Barre syndrome progressing to chronic inflammatory demyelinating polyneuropathy in a patient with Marfan's syndrome and pulmonary tuberculosis
    Z Soehardy
    Department of Medicine and Department of Anaesthesiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia
    Med J Malaysia 60:655-6. 2005
    ..Nerve conduction, MRI and CSF studies were done to confirm a first case report of AMSAN variant progressing to CIDP in a patient with Marfan's syndrome and pulmonary tuberculosis...
  58. pmc Evidence for acquisition of the lipooligosaccharide biosynthesis locus in Campylobacter jejuni GB11, a strain isolated from a patient with Guillain-Barré syndrome, by horizontal exchange
    Michel Gilbert
    Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada
    Infect Immun 72:1162-5. 2004
    ..These data indicate that the antiganglioside response in the GB11-infected patient was raised against the structures synthesized by the acquired class A LOS locus...
  59. ncbi Absence of clonality of Campylobacter jejuni in serotypes other than HS:19 associated with Guillain-Barré syndrome and gastroenteritis
    J Engberg
    Department of Gastrointestinal Infections, Division of Diagnostics, Statens Serum Institut, Copenhagen, Denmark
    J Infect Dis 184:215-20. 2001
    ..The results show that these isolates represent a heterogenic population and do not constitute a unique population across serotypes. No epidemiologic marker for GBS-associated strains was identified...
  60. ncbi Effect of methylprednisolone when added to standard treatment with intravenous immunoglobulin for Guillain-Barré syndrome: randomised trial
    R van Koningsveld
    Department of Neurology, Erasmus MC, Rotterdam, Netherlands
    Lancet 363:192-6. 2004
    ..Our aim was to assess whether methylprednisolone, when taken with IVIg, improves outcome when compared with IVIg alone...
  61. pmc Molecular evidence for dissemination of unique Campylobacter jejuni clones in Curaçao, Netherlands Antilles
    Birgitta Duim
    Department of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands
    J Clin Microbiol 41:5593-7. 2003
    ..Furthermore, given the observation that C. jejuni-associated diseases appear to be more severe from November to February, it can be speculated that this may be due to the presence of virulent clones with a limited span of circulation...
  62. ncbi [Contribution of corticosteroid to the treatment of pain in the acute phase of Guillain-Barré syndrome]
    R Kabore
    Service de Neurologie, CHRU Dupuytren, Limoges
    Rev Neurol (Paris) 160:821-3. 2004
    ..We report four patients with GBS whose pain was rapidly relieved by administration of corticosteroids...
  63. ncbi Prospective study of clinical epidemiology of Guillain-Barré syndrome in Harbin, China
    Qi Cheng
    Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    J Neurol Sci 215:63-9. 2003
    ..Clinical and epidemiological differences of GBS might exist between various populations...
  64. ncbi Inflammatory infiltrates in the spinal cord of patients with Guillain-Barré syndrome
    H D Müller
    Institut für Neuropathologie, Universitätsklinikum der Rheinisch Westfälischen Hochschule Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    Acta Neuropathol 106:509-17. 2003
    ..Insignificant cellular infiltrates in the spinal cord were noted in the other two GBS cases. Focal cellular infiltration of spinal nerve roots and meninges was similar in all cases...
  65. ncbi Guillain Barre syndrome with brisk reflexes-another variant
    A Somarajan
    Neurol India 54:215-6. 2006
  66. ncbi Axonal Guillain-Barré syndrome: carbohydrate mimicry and pathophysiology
    Nobuhiro Yuki
    Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Tochigi, Japan
    J Peripher Nerv Syst 12:238-49. 2007
    ..Immunological, pathological, electrophysiological, and bacteriological studies have provided strong evidence of carbohydrate mimicry being a cause of AMAN and clarified the mechanisms of nerve conduction failure in AMAN...
  67. ncbi Guillain-Barré syndrome in northwest Greece
    S Markoula
    Department of Neurology, University of Ioannina, Medical School, Ioannina, Greece
    Acta Neurol Scand 115:167-73. 2007
    ..We present the epidemiological and clinical-laboratory features of Guillain-Barré syndrome (GBS) in northwest Greece over a 9.5-year period...
  68. ncbi Analysing the favourable effects of physical exercise: relationships between physical fitness, fatigue and functioning in Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy
    Johannes B J Bussmann
    Department of Rehabilitation Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Rehabil Med 39:121-5. 2007
    ....
  69. ncbi Molecular population genetic analysis of Campylobacter jejuni HS:19 associated with Guillain-Barré syndrome and gastroenteritis
    I Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    J Infect Dis 184:221-6. 2001
    ..The results of this study show that HS:19 strains comprise a clonal, although not monomorphic, population, which is distinct from non-HS:19 strains within C. jejuni. A unique clone associated with GBS was not identified by use of MLEE...
  70. ncbi Proteomic identification of potential protein markers in cerebrospinal fluid of GBS patients
    T Jin
    Department of Neurology, The First Hospital, Jilin University, Changchun, China
    Eur J Neurol 14:563-8. 2007
    ..We concluded that these six proteins may be involved in the pathogenesis of GBS and call for further studying the role of these proteins in the pathogenesis of the disease...
  71. ncbi Severe backache in Guillain-Barré syndrome
    Marisa Sanchez-Guerra
    Muscle Nerve 25:468. 2002
  72. ncbi Weakness after gastric bypass
    Craig G Chang
    Department of Surgery, Bayne Jones Army Community Hospital, Fort Polk, LA, USA
    Obes Surg 12:592-7. 2002
    ..The clinical presentations of these patients are very similar to case reports of nutritional polyneuropathy associated with gastric partitioning. This paper addresses the difficulties of differentiating these two diagnoses...
  73. ncbi Gastroenteritis-associated Guillain-Barré syndrome on the Caribbean island Curaçao
    R van Koningsveld
    Department of Neurology, Erasmus University Medical Center Rotterdam, The Netherlands
    Neurology 56:1467-72. 2001
    ..The number of patients with Guillain-Barré syndrome (GBS) who have been observed in Curaçao, the Netherlands Antilles, may be increasing...
  74. ncbi Acquired inflammatory demyelinating neuropathies
    E R Ensrud
    Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA
    Phys Med Rehabil Clin N Am 12:321-34, ix. 2001
    ..The clinical features, pathology, pathogenesis, diagnosis, treatment, rehabilitation, and prognosis of these neuropathies are discussed...
  75. pmc Guillain-Barré syndrome- and Miller Fisher syndrome-associated Campylobacter jejuni lipopolysaccharides induce anti-GM1 and anti-GQ1b Antibodies in rabbits
    C W Ang
    Department of Neurology, Erasmus University, Rotterdam, The Netherlands
    Infect Immun 69:2462-9. 2001
    ..jejuni LPS results in antiganglioside antibodies. These results provide strong support for molecular mimicry as a mechanism in the induction of antiganglioside antibodies following infections...
  76. pmc Amplified fragment length polymorphism analysis of Campylobacter jejuni strains isolated from chickens and from patients with gastroenteritis or Guillain-Barré or Miller Fisher syndrome
    B Duim
    Department of Bacteriology, Institute for Animal Science and Health, Lelystad, The Netherlands
    Appl Environ Microbiol 66:3917-23. 2000
    ..We conclude that C. jejuni from chickens cannot be distinguished from human strains and that GBS or MFS related strains do not belong to a distinct genetic group...
  77. ncbi Campylobacter jejuni cst-II polymorphisms and association with development of Guillain-Barré syndrome
    Michiaki Koga
    Neurology 69:1727-8; author reply 1728. 2007
  78. ncbi Biosynthesis of ganglioside mimics in Campylobacter jejuni OH4384. Identification of the glycosyltransferase genes, enzymatic synthesis of model compounds, and characterization of nanomole amounts by 600-mhz (1)h and (13)c NMR analysis
    M Gilbert
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada
    J Biol Chem 275:3896-906. 2000
    ..jejuni OH4384 were confirmed by comparing their sequence and activity with corresponding homologues in two related C. jejuni strains that express shorter ganglioside mimics in their LOS...
  79. pmc Genetic characterization of Campylobacter jejuni O:41 isolates in relation with Guillain-Barré syndrome
    T M Wassenaar
    Department of Medical Microbiology, University of Cape Town, Observatory, Cape 7925, South Africa
    J Clin Microbiol 38:874-6. 2000
    ..Despite minor variation in GM1 expression, all of the strains were genetically indistinguishable, indicating that they are representative of a genetically stable clone...
  80. ncbi gamma delta T cells infiltrating sensory nerve biopsies from patients with inflammatory neuropathy
    John Winer
    Division of Neuroscience, University of Birmingham, Edgbaston, Birmingham, B15 2TH, UK
    J Neurol 249:616-21. 2002
    ....
  81. ncbi Residual fatigue is independent of antecedent events and disease severity in Guillain-Barré syndrome
    M P J Garssen
    Department of Neurology, Erasmus University Medical Center Rotterdam, PO Box 1738, 3000 Rotterdam, Dr, The Netherlands
    J Neurol 253:1143-6. 2006
    ..01). There was no significant relationship between fatigue severity and the level of functional disability at nadir, antecedent events or infections, clinical variables, and time to follow-up after GBS...
  82. ncbi Influenza vaccination and Guillain Barre syndrome
    Mark R Geier
    The Genetic Centers of America, 14 Redgate Court, Silver Spring, MD 20905, USA
    Clin Immunol 107:116-21. 2003
    Acute and severe Guillain Barre Syndrome (GBS) cases reported following influenza vaccine to the Vaccine Adverse Events Reporting System (VAERS) database from 1991 through 1999 were examined...
  83. ncbi Contribution of central and peripheral factors to residual fatigue in Guillain-Barré syndrome
    Marcel P J Garssen
    Department of Neurology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Muscle Nerve 36:93-9. 2007
    ..This study thus provides further insight into the factors contributing to residual fatigue in GBS patients...
  84. pmc Antibody responses to peptides of peripheral nerve myelin proteins P0 and P2 in patients with inflammatory demyelinating neuropathy
    H R Inglis
    Neuroimmunology Research Centre, The University of Queensland, Brisbane, Queensland, Australia
    J Neurol Neurosurg Psychiatry 78:419-22. 2007
    ....
  85. ncbi Guillain-Barré syndrome after varicella zoster virus infections. A case report
    P Pavone
    Dipartimento di Pediatria, Universita degli Studi, Catania, Italy
    Minerva Pediatr 54:259-62. 2002
    ..The therapy was carried out with increasing high-doses of immunoglobulins, with full clinical recovery...
  86. ncbi Ganglioside mimicry and peripheral nerve disease
    Nobuhiro Yuki
    Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Muscle Nerve 35:691-711. 2007
    ..Acute and chronic inflammatory demyelinating polyneuropathies may be produced by mechanisms other than ganglioside mimicry...
  87. ncbi Pathogenesis of Guillain-Barré syndrome
    R A Hughes
    Department of Neuroimmunology, Guy s, King s and St Thomas School of Medicine, Guy s Hospital, London, UK
    J Neuroimmunol 100:74-97. 1999
    ..The different patterns of GBS are probably due to the diverse interplay between antibodies and T cells of differing specificities...
  88. ncbi IgG antiganglioside antibodies in Guillain-Barré syndrome with bulbar palsy
    H Yoshino
    Department of Neurology, Kohnodai Hospital, National Center of Neurology and Psychiatry, Kohnodai 1 7 1, Ichikawa, Chiba, Japan
    J Neuroimmunol 105:195-201. 2000
    ....
  89. ncbi Haemophilus influenzae as a possible cause of Guillain-Barré syndrome
    Y Y Ju
    Department of Clinical Neurosciences, Guy s, King s, and St Thomas School of Medicine, Guy s Hospital, Hodgkin Building, St Thomas Street, London SE1 1UL, UK
    J Neuroimmunol 149:160-6. 2004
    ..influenzae absorbed the anti-LPS antibodies. In conclusion, there is a possible but rare association of GBS with nonencapsulated H. influenzae in the UK...
  90. ncbi Guillain-Barré syndrome associated with Campylobacter jejuni infection in England, 2000-2001
    Clarence C Tam
    Gastrointestinal Diseases Division, Communicable Disease Surveillance Centre, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Clin Infect Dis 37:307-10. 2003
    ..jejuni. We estimate that, between 1 April 2000 and 31 March 2001, symptomatic C. jejuni infection was responsible for 157 cases of GBS, constituting approximately 15% of all GBS cases in England...
  91. pmc Campylobacter jejuni from patients with Guillain-Barré syndrome preferentially expresses a GD(1a)-like epitope
    Irving Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    Infect Immun 70:5299-303. 2002
    ..GD(1a)-like epitope expression may be an important virulence phenotype associated with the risk of developing GBS following campylobacter infection...
  92. ncbi Campylobacter jejuni cst-II polymorphisms and association with development of Guillain-Barré syndrome
    John B Hye
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Neurology 68:1633-4. 2007
  93. ncbi [Campylobacter jejuni and cytomegalovirus (CMV) infections in patients with the Guillain-Barre syndrome]
    D Orlikowski
    Service de Reanimation Medicale, Hopital Raymond Poincare, 104, Boulevard Raymond Poincare, 92380 Garches, France
    Arch Pediatr 13:1561-5. 2006
    ..There is no proof, at this time, that anti-infectious treatment can improve the prognosis. The treatment is based on the early use of immunomodulatory treatments like intravenous immunoglobulins or plasma exchanges...
  94. ncbi Bacterial infections in Guillain-Barré and Fisher syndromes
    Nobuhiro Yuki
    Department of Neurology and Research Institute for Neuroimmunological Diseases, Dokkyo Medical University School of Medicine, Tochigi, Japan
    Curr Opin Neurol 19:451-7. 2006
    ..Progress has been made in our understanding of Guillain-Barré syndrome, especially in identifying the Campylobacter jejuni genes responsible for the development of clinical features...
  95. ncbi Subclass IgG to motor gangliosides related to infection and clinical course in Guillain-Barré syndrome
    Bart C Jacobs
    Department of Neurology, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Neuroimmunol 194:181-90. 2008
    ..These findings support a model in which C. jejuni and H. influenzae infections induce two distinct patterns of cross-reactive antibodies with different clinical outcome...
  96. ncbi [A case of acute oropharyngeal palsy with nasal voice as main symptom]
    Yuko Wada
    Department of Neurology, Nishi Kobe Medical Center, Japan
    No To Shinkei 58:235-8. 2006
    ..Therefore, neurologists should take into account the possibility of Guillain-Barré syndrome and the regional variants in patients who show nasal voice during the initial stage...
  97. ncbi [A case of Bickerstaff brainstem encephalitis concomitant with axonal Guillain-Barre syndrome and ballism successfully treated with intravenous immunoglobulin treatment]
    Fumi Makino
    Department of Neurology, Ijinkai Takeda General Hospital
    Rinsho Shinkeigaku 48:501-4. 2008
    ..It is thus conceivable that anti-GQ1b IgG antibody might underlie the pathogenesis of all three conditions...
  98. ncbi Preceding infections and anti-ganglioside antibodies in patients with Guillain-Barré syndrome: a single centre prospective case-control study
    S Sinha
    Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Clin Microbiol Infect 13:334-7. 2007
    ..13/125; p <0.001), and a higher proportion of axonal cases had these antibodies than did AIDP patients (43/46 vs. 22/34; p <0.01)...
  99. ncbi [Guillain-Barré syndrome]
    Susumu Kusunoki
    Department of Neurology, Kinki University School of Medicine
    Nihon Rinsho 63:427-31. 2005
  100. ncbi Acute inflammatory sensorimotor polyradiculoneuropathy associated with immune thrombocytopenic purpura
    N Sato
    Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan
    J Intern Med 257:473-7. 2005
    ..By reviewing past similar reports, we noticed that AIP associated with ITP tends to manifest severe sensory impairment and is often preceded by upper respiratory tract infection, but not by gastrointestinal infection...
  101. pmc Prognosis in the acute motor axonal form of Guillain-Barré syndrome
    C M Gabriel
    J Neurol Neurosurg Psychiatry 76:622. 2005

Research Grants53

  1. 16th international conference on Campylobacter, Helicobacter and related organism
    Irving Nachamkin; Fiscal Year: 2011
    ....
  2. Generation of monoclonal and polyclonal antibodies to neolacto-series ganglioside
    Amjad A Ilyas; Fiscal Year: 2010
    ..Development of high-affinity antibodies to these important gangliosides would provide powerful tools to probe their physiological functions in health and disease. ..
  3. Pathophysiology of Conduction Block in HNPP.
    Jun Li; Fiscal Year: 2013
    ..Our study investigates molecular mechanisms responsible for the CB using HNPP and its animal model. ..
  4. Alpha M Beta 2 integrin blockade for acute inflammatory neuropathies
    EROBOGHENE EKAMERENO UBOGU; Fiscal Year: 2013
    ..abstract_text> ..
  5. Protection against acute inflammatory demyelinating peripheral nerve disease
    EVAN STUBBS; Fiscal Year: 2009
    ....
  6. Mechanisms of Neuropathic Pain in Demylenated Nerves
    Fletcher A White; Fiscal Year: 2010
    ..abstract_text> ..
  7. Autoimmune mechanisms in a novel Aire-deficient model of peripheral neuropathy
    Maureen A Su; Fiscal Year: 2013
    ..Additionally, findings from these studies will contribute to a broader understanding of how Aire functions to prevent autoimmunity. ..
  8. Campylobacter colonization and virulence determinants
    Alain Stintzi; Fiscal Year: 2007
    ..The identification of these Campylobacter determinants could significantly contribute to the development of more effective methods to diagnose, manage and ultimately prevent Campylobacter infections. ..
  9. Campylobacter jejuni proteins induced at 37C
    Stuart Thompson; Fiscal Year: 2007
    ..jejuni proteins that are induced at 37C.Specific Aim 3. Elucidate the roles of specific 37C-induced proteins in human epithelial cell binding and invasion in vitro, and in colonization in a mouse model. ..
  10. Phenotype MicroArray Analysis of Fastidious Pathogens
    Barry Bochner; Fiscal Year: 2004
    ..and also (with some strains) of an autoimmune induced peripheral nerve degeneration and paralysis - Guillain Barre syndrome). Cj and Hp are each genetically diverse...
  11. ROLE OF NERVOUS SYSTEM MAST CELLS IN DEMYELINATION
    David Johnson; Fiscal Year: 1990
    ....
  12. MECHANISM OF INJURY IN THE GUILLAIN BARRE SYNDROME
    Tony Ho; Fiscal Year: 1999
    ....
  13. Analysis of Campylobacter coli Lipooligosaccharide Core Diversity
    MARGARET KANIPES; Fiscal Year: 2006
    ..A small but significant number of Campylobacter infections have also been linked to the development of Guillain Barre Syndrome (GBS)...
  14. Probing the Glycan Biosynthetic Machinery of Campylobacter Jejuni.
    JERRY TROUTMAN; Fiscal Year: 2009
    ....
  15. CHINESE PARALYTIC SYNDROME - MECHANISMS AND RELEVANCE
    GUY MC KHANN; Fiscal Year: 2001
    ..abstract_text> ..
  16. BIOSYNTHESIS AND ASSEMBLY OF MYELIN MEMBRANE PROTEINS
    David Colman; Fiscal Year: 2006
    ..abstract_text> ..
  17. MAMMALIAN CELL CYCLE BLOCK BY A C JEJUNI CYTOTOXIN
    CAROL PICKETT; Fiscal Year: 1999
    ..In aim 3, the nature of the G2 block caused by CDT will be examined in greater detail. Under aim 4, the ability of CDT to contribute to C. jejuni diarrheal disease in a piglet model will be tested. ..
  18. Utility of the P300 Brain-Computer Interface for Patients in Acute Care Environme
    Leigh Hochberg; Fiscal Year: 2009
    ..This research aims to test and develop a "brain-computer interface" system that could restore the ability to type words, just by looking at letters as they flash on a computer screen. ..
  19. DEMYELINATION IN MULTIPLE SCLEROSIS
    MOON SHIN; Fiscal Year: 1999
    ..process underlying immune mediated demyelination occurring in diseases such as multiple sclerosis and Guillain Barre syndrome. We have previously focused our studies on pathobiology of demyelination induced by complement, ..
  20. MYELIN P2 PROTEIN--STUDY OF EXPRESSION AND REGULATION
    Vinodh Narayanan; Fiscal Year: 1992
    ....
  21. CAMPYLOBACTER JEJUNI CYTOLETHAL DISTENDING TOXIN
    CAROL PICKETT; Fiscal Year: 2001
    ..In Aim 4, a HeLa cell expression system will be used to complement and extend the studies in the first 3 aims. In summary, these studies are designed to increase our understanding of CDT and the mechanism by which it causes a G2 block. ..
  22. 10TH INTERNATIONAL WORKSHOP ON CAMPYLOBACTER, HELICOBACT
    HARRY MOBLEY; Fiscal Year: 1999
    ..This is the first such meeting to be held in the United States. The site of the meeting is Baltimore, Maryland, a location convenient for large numbers of attendees from North America and Europe. ..
  23. The Pathophysiology of Conduction Block in HNPP
    Jun Li; Fiscal Year: 2009
    ..Aim 3: Test the hypothesis that increasing age or multiple injuries predispose CB in pmp22 +/- and wild type mice. ..
  24. PRODUCTIVE AND ABORTIVE INFLUENZA VIRUS INFECTION OF CNS
    Gary Bradshaw; Fiscal Year: 1990
    ..v. or i.p. inoculation, at various times, of the same or different strains or subtypes and monitor for neuropathology...
  25. Development of Soluble FcR-Ig Fusion Proteins
    Leslie Johnson; Fiscal Year: 2004
    ..We believe that an FcR blockade would also be potentially useful in treating autoimmune hemolytic anemia, lupus, rheumatoid arthritis, Guillain-Barre syndrome and stiff man's syndrome. ..
  26. NEURON-NEUROGLIA INTERACTIONS
    Peter Shrager; Fiscal Year: 2004
    ..This information will then be helpful in designing therapies for diseases of the brain, spinal cord, and periphery. ..
  27. 14th International CHRO Workshop
    Irving Nachamkin; Fiscal Year: 2007
    ..abstract_text> ..
  28. 13th International Campylobacter/Helicobacter workshop
    Irving Nachamkin; Fiscal Year: 2005
    ..abstract_text> ..
  29. PHARMACOLOGICAL STUDIES OF HUMAN AND CANINE NARCOLEPSY
    Seiji Nishino; Fiscal Year: 2002
    ....
  30. Role of Histamine in Narcolepsy/EDS Disorders
    Seiji Nishino; Fiscal Year: 2008
    ..As almost nothing is known on the pathophysiology of non- hypocretin deficient hypersomnias, we believe this work to be ideally suited for a small grant application. [unreadable] [unreadable] [unreadable]..
  31. Role of hypocretin/histamine in Narcolepsy/EDS disorders
    Seiji Nishino; Fiscal Year: 2009
    ..We believe that results from these studies will bring new insights regarding the roles of the hypocretin/histamine interaction in narcolepsy and other EDS disorders and better treatment modalities in humans. ..
  32. Immunoglobulin Allotypes in Hepatitis C Virus Infection
    JANARDAN PANDEY; Fiscal Year: 2008
    ..Results of this investigation will advance our understanding of the role of host genetic factors in clearance and persistence of hepatitis C virus infection. ..
  33. Shoulder Pain in Spinal Cord Injury (SCI): A Longitudinal Study
    Sara J Mulroy; Fiscal Year: 2010
    ..MANOVA will be employed to compare the biomechanical parameters of WCP for the shoulder pain and pain-free groups. ..
  34. Pandemic influenza control at the borders of island countries and in household
    Michael Baker; Fiscal Year: 2008
    ..Findings from the housing cohort would be used to guide advice about reducing influenza transmission in households, particularly in terms of crowding levels and exposure to active and passive smoking. ..
  35. SPHINGOGLYCOLIPIDS OF NORMAL AND PATHOLOGICAL BRAINS
    Robert K Yu; Fiscal Year: 2010
    ..abstract_text> ..
  36. Epidemiology of Hep E Virus Infections in Bangladesh
    Kenrad Nelson; Fiscal Year: 2003
    ..abstract_text> ..
  37. Immune reactivity to synapsin in the neuropathy and ataxia of celiac disease
    Armin Alaedini; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  38. American Society for Neurochemistry Conference
    Robert Yu; Fiscal Year: 2003
    ..Several of the sessions contain elements from more than one theme, and such intellectual overlaps enhance scientific interactions. ..
  39. INTERVENTIONS FOR SCI SHOULDER FUNCTION IN WHEELCHAIRS
    Sara Mulroy; Fiscal Year: 2004
    ..Statistical significance of the findings will be determined by repeated measures MANOVA analyses with grouping factors for SCI level and exercise/control groups. ..
  40. Bayesian Methods-Combining Evidence from Interventions
    Joel Greenhouse; Fiscal Year: 2004
    ....
  41. The Electrophysiology of Motor Neuron Diseases
    Mark Bromberg; Fiscal Year: 2002
    ..Currently, most MUNE techniques rely on proprietary software. We will develop software for use on PC-based computer systems, making them available to all laboratories. ..
  42. THE EPIDEMIOLOGY OF HEPATITIS C INFECTION IN THAILAND
    Kenrad Nelson; Fiscal Year: 2004
    ..Through the transfer of technology for HCV research to our collaborators, we hope to focus on understanding the biology and epidemiology of HCV and the development of more effective prevention of HCV. ..
  43. BAYESIAN METHODS IN BIOSTATISTICS
    Joel Greenhouse; Fiscal Year: 2002
    ..Yet, despite great progress in the use of these models, fundamental issues remain, as we explain below, this is the main motivation of our work. ..
  44. A Novel Inflammatory Signal in Pulmonary Neutrophilia
    Nathaniel Weathington; Fiscal Year: 2007
    ....
  45. HYPOGLYCEMIA AND AUTONOMIC NERVOUS SYSTEM FUNCTION
    Roy Freeman; Fiscal Year: 2007
    ..Thus, the broad long term objectives of the proposal are to fully understand the mechanisms and consequences of hypoglycemia associated autonomic failure with the ultimate goal of finding an efficacious treatment. ..
  46. OspA and autoimmunity in chronic Lyme disease
    Armin Alaedini; Fiscal Year: 2007
    ..Identification of specific immune reactivity to an autoantigen might also be useful as a diagnostic marker and for monitoring of disease activity in affected patients. [unreadable] [unreadable] [unreadable]..
  47. Neurogenic effects of amyloid beta-proteins & gangliosides in Alzheimer's Disease
    Robert Yu; Fiscal Year: 2007
    ..Our long-term goal is to develop a ganglioside therapy for enhancing neurogenesis in AD. [unreadable] [unreadable] [unreadable]..
  48. Prevalence and Epidemiology of Hepatitis E Virus in the United States
    Kenrad Nelson; Fiscal Year: 2008
    ..abstract_text> ..
  49. Evaluation of the Control of HIV After a Prison Amnesty in Taiwan
    Kenrad Nelson; Fiscal Year: 2008
    ..unreadable] [unreadable] The collaboration is between the Bloomberg School of Public Health of Johns Hopkins University and the Center for Disease Control in Taiwan. [unreadable] [unreadable] [unreadable]..