nervous system diseases

Summary

Summary: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.

Top Publications

  1. pmc Clinical and prognostic features among children with acute encephalitis syndrome in Nepal; a retrospective study
    Ajit Rayamajhi
    Department of Paediatrics, Kanti Children s Hospital, Maharajgunj, Kathmandu, Nepal
    BMC Infect Dis 11:294. 2011
  2. pmc Association of pesticide exposure with neurologic dysfunction and disease
    Freya Kamel
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 112:950-8. 2004
  3. ncbi Microglia: gatekeepers of central nervous system immunology
    Bart R Tambuyzer
    Laboratory of Neurobiology and Neuropharmacology, Department of Biomedical Sciences, and Vaccine and Infectious Disease Institute, University of Antwerp, Universiteitsplein 1, Wilrijk, Belgium
    J Leukoc Biol 85:352-70. 2009
  4. ncbi Risk factors for bullous pemphigoid in the elderly: a prospective case-control study
    Sylvie Bastuji-Garin
    Faculte de Medecine, LIC EA4393, Universite Paris Est, Creteil, France
    J Invest Dermatol 131:637-43. 2011
  5. ncbi Protective effect of chuanxiongzine-puerarin in a rat model of transient middle cerebral artery occlusion-induced focal cerebral ischemia
    Haitong Wan
    Institute of Cardio Cerbrovascular Disease, Zhejiang Chinese Medical University, China
    Nucl Med Commun 29:1113-22. 2008
  6. pmc The axon initial segment in nervous system disease and injury
    Shelly A Buffington
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, BCM295, Houston, TX 77030, USA
    Eur J Neurosci 34:1609-19. 2011
  7. ncbi The quality of the early motor repertoire in preterm infants predicts minor neurologic dysfunction at school age
    Janneke L M Bruggink
    Department of Pediatrics, Division of Neonatology, Beatrix Children s Hospital, University Medical Center Groningen, Groningen, The Netherlands
    J Pediatr 153:32-9. 2008
  8. pmc DISC1 and Huntington's disease--overlapping pathways of vulnerability to neurological disorder?
    Ruth Boxall
    Medical Genetics Section, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    PLoS ONE 6:e16263. 2011
  9. pmc Cellular reprogramming: recent advances in modeling neurological diseases
    Guo li Ming
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 31:16070-5. 2011
  10. ncbi Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations
    Marco Gattorno
    Second Division of Pediatrics, IRCCS, Istituto G Gaslini, Genoa, Italy
    Arthritis Rheum 56:3138-48. 2007

Detail Information

Publications287 found, 100 shown here

  1. pmc Clinical and prognostic features among children with acute encephalitis syndrome in Nepal; a retrospective study
    Ajit Rayamajhi
    Department of Paediatrics, Kanti Children s Hospital, Maharajgunj, Kathmandu, Nepal
    BMC Infect Dis 11:294. 2011
    ..Japanese Encephalitis (JE) accounts for approximately one-quarter of cases. Although poor prognostic features for JE have been identified, and guide management, relatively little is reported on the remaining three-quarters of AES cases...
  2. pmc Association of pesticide exposure with neurologic dysfunction and disease
    Freya Kamel
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 112:950-8. 2004
    ..Major unresolved issues include the relative importance of acute and chronic exposure, the effect of moderate exposure in the absence of poisoning, and the relationship of pesticide-related neurotoxicity to neurodegenerative disease...
  3. ncbi Microglia: gatekeepers of central nervous system immunology
    Bart R Tambuyzer
    Laboratory of Neurobiology and Neuropharmacology, Department of Biomedical Sciences, and Vaccine and Infectious Disease Institute, University of Antwerp, Universiteitsplein 1, Wilrijk, Belgium
    J Leukoc Biol 85:352-70. 2009
    ..This review about microglia aims to introduce the reader extensively into their ontogeny, cell biology, and involvement in different neuropathologies...
  4. ncbi Risk factors for bullous pemphigoid in the elderly: a prospective case-control study
    Sylvie Bastuji-Garin
    Faculte de Medecine, LIC EA4393, Universite Paris Est, Creteil, France
    J Invest Dermatol 131:637-43. 2011
    ..30-0.81). Thus, risk factors for BP include neurological disorders, particularly dementia and Parkinson's disease, psychiatric disorders (unipolar and bipolar disorders), bedridden condition, and chronic use of several drugs...
  5. ncbi Protective effect of chuanxiongzine-puerarin in a rat model of transient middle cerebral artery occlusion-induced focal cerebral ischemia
    Haitong Wan
    Institute of Cardio Cerbrovascular Disease, Zhejiang Chinese Medical University, China
    Nucl Med Commun 29:1113-22. 2008
    ..The aim of this study was to investigate the protective effect of chuanxiongzine-puerarin on cerebral ischemia-reperfusion damage in a rat model...
  6. pmc The axon initial segment in nervous system disease and injury
    Shelly A Buffington
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, BCM295, Houston, TX 77030, USA
    Eur J Neurosci 34:1609-19. 2011
    ..Here, we consider the role of the AIS in nervous system disease and injury...
  7. ncbi The quality of the early motor repertoire in preterm infants predicts minor neurologic dysfunction at school age
    Janneke L M Bruggink
    Department of Pediatrics, Division of Neonatology, Beatrix Children s Hospital, University Medical Center Groningen, Groningen, The Netherlands
    J Pediatr 153:32-9. 2008
    ..Its predictive power for minor neurologic dysfunction (MND) is unclear. This study aimed to investigate the predictive value of the quality of the early motor repertoire for the development of MND at school age...
  8. pmc DISC1 and Huntington's disease--overlapping pathways of vulnerability to neurological disorder?
    Ruth Boxall
    Medical Genetics Section, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    PLoS ONE 6:e16263. 2011
    ..The potential link between DISC1, huntingtin and their interacting partners may open new areas of research into the effects of pathway dysregulation in severe neurological disorders...
  9. pmc Cellular reprogramming: recent advances in modeling neurological diseases
    Guo li Ming
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 31:16070-5. 2011
    ....
  10. ncbi Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations
    Marco Gattorno
    Second Division of Pediatrics, IRCCS, Istituto G Gaslini, Genoa, Italy
    Arthritis Rheum 56:3138-48. 2007
    ....
  11. ncbi Induced pluripotent stem cells: a new revolution for clinical neurology?
    Virginia B Mattis
    Regenerative Medicine Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Lancet Neurol 10:383-94. 2011
    ..Hence, this swiftly growing area of research has the potential to contribute greatly to our understanding of the pathophysiology of neurodegenerative and neurodevelopmental diseases...
  12. ncbi You say lipofuscin, we say ceroid: defining autofluorescent storage material
    Sabrina S Seehafer
    Center for Aging and Developmental Biology, Aab Institute of Biomedical Sciences, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642, USA
    Neurobiol Aging 27:576-88. 2006
    ....
  13. ncbi Induced pluripotent stem cells from hair follicles as a cellular model for neurodevelopmental disorders
    I Petit
    INSERM U898, Nice, France
    Stem Cell Res 8:134-40. 2012
    ....
  14. ncbi Development and validation of the Neuropathic Pain Symptom Inventory
    Didier Bouhassira
    INSERM E 332, Center d Evaluation t de Traitement de la Douleur, Hôspiat Ambroise paré, Boulogne Billancourt, France
    Pain 108:248-57. 2004
    ....
  15. ncbi Tacit and encoded knowledge in the use of standardised outcome measures in multidisciplinary team decision making: a case study of in-patient neurorehabilitation
    Joanne Greenhalgh
    School of Healthcare, University of Leeds, Leeds LS2 9UT, UK
    Soc Sci Med 67:183-94. 2008
    ..Tacit knowledge is essential to produce and interpret this form of encoded knowledge and to balance its significance against other information about the patient in making decisions about patient care...
  16. ncbi The development of neural stem cells
    S Temple
    Center for Neuropharmacology and Neurosciences, Albany Medical College, Albany, New York 12208, USA
    Nature 414:112-7. 2001
    ..Can these views be reconciled?..
  17. ncbi Neurological disorders in patients with bullous pemphigoid
    Nadege Cordel
    Department of Dermatology, Pointe à Pitre University Hospital, Pointe a Pitre, Guadeloupe, Pointe A Pitre cedex, France
    Dermatology 215:187-91. 2007
    ..Unexpected cases of bullous pemphigoid (BP) have been reported in adult patients with various neurological disorders suggesting a possible relationship between these diseases...
  18. pmc Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage
    Michael L James
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 40:632-9. 2009
    ..The purpose of the study was to evaluate the effect of APOE genotype and the feasibility of administering an apolipoprotein E-mimetic therapeutic to modify outcomes in a murine model of intracerebral hemorrhage...
  19. ncbi The cerebral vasculature as a therapeutic target for neurological disorders and the role of shear stress in vascular homeostatis and pathophysiology
    Ljiljana Krizanac-Bengez
    Cerebrovascular Research Center, Neurosurgery NB 20, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Neurol Res 26:846-53. 2004
    ..This review summarizes the most recent data related to cerebral vasculature as a therapeutic target for neurological disorders and the role of shear stress in blood-brain barrier homeostasis and pathophysiology...
  20. ncbi Improved survival rates with increased neurodevelopmental disability for extremely low birth weight infants in the 1990s
    Deanne Wilson-Costello
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
    Pediatrics 115:997-1003. 2005
    ....
  21. pmc Diversity in NMDA receptor composition: many regulators, many consequences
    Antonio Sanz-Clemente
    National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
    Neuroscientist 19:62-75. 2013
    ..In addition, the balance between synaptic and extrasynaptic NMDARs is altered in several neuronal disorders. Here, the authors summarize the recent advances in the identification of NMDAR subunit-specific regulatory mechanisms...
  22. ncbi The relationship between neurological disease and bullous pemphigoid: a population-based case-control study
    Sinead M Langan
    Department of Immunodermatology, St John s Institute of Dermatology, King s College, London, UK
    J Invest Dermatol 131:631-6. 2011
    ..Mechanisms for disease occurrence based on these findings include immobility or age-related autoimmunity...
  23. ncbi The possible involvement of glycogen synthase kinase-3 (GSK-3) in diabetes, cancer and central nervous system diseases
    S Amar
    Psychiatry Research Unit, Ben Gurion University of the Negev, Beer Sheva, Israel
    Curr Pharm Des 17:2264-77. 2011
    ..Further development of GSK-3 inhibitors for clinical trials should be approached with caution...
  24. ncbi Sera of elderly bullous pemphigoid patients with associated neurological diseases recognize bullous pemphigoid antigens in the human brain
    Jinbo Chen
    Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Gerontology 57:211-6. 2011
    ..However, it is not known whether the serum of BP+ND patients could recognize BPAG1 in the human brain...
  25. ncbi Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises
    Maria C Marchetto
    Laboratory of Genetics LOG G, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Hum Mol Genet 20:R109-15. 2011
    ..Combined with other technologies previously used to study brain disease, iPSC modeling has the promise to influence modern medicine on several fronts: early diagnosis, drug development and effective treatment...
  26. ncbi Health, neurologic, and cognitive status of HIV-infected, long-surviving, and antiretroviral-naive Ugandan children
    Danstan Bagenda
    Makerere University Medical School, Kampala, Uganda
    Pediatrics 117:729-40. 2006
    ....
  27. ncbi Neurolupus
    Fady G Joseph
    Consultant Neurologist, Neville Hall Hospital, Abergavenny and the Royal Gwent Hospital, Newport, UK
    Pract Neurol 10:4-15. 2010
    ....
  28. ncbi Bullous pemphigoid and internal diseases - A case-control study
    Hana Jedlickova
    Ist Department of Dermatovenereology, Masaryk University, St Anna Faculty Hospital, 656 91, Brno, Czech Republic
    Eur J Dermatol 20:96-101. 2010
    ..55; 95% confidence interval 2.68 to 41.49). Most frequent were cerebral stroke in men and dementia in women. For other diseases and other age groups, no statistically significant influence was found...
  29. ncbi Neurologic and neurobehavioral sequelae in children with human immunodeficiency virus (HIV-1) infection
    Rajeshree Govender
    Department of Paediatric Neurology, Red Cross Children s Hospital, School of Child and Adolescent Health, University of Cape Town, South Africa
    J Child Neurol 26:1355-64. 2011
    ..Children with severe immunosuppression, who were not receiving antiretroviral therapy, were growth impaired and less than 1 year of age, were at greatest risk for developing neurologic complications...
  30. ncbi Improvement in neurological outcome and abolition of cerebrovascular endothelin B and 5-hydroxytryptamine 1B receptor upregulation through mitogen-activated protein kinase kinase 1/2 inhibition after subarachnoid hemorrhage in rats
    Carl Christian Larsen
    Departments of Neurosurgery, Glostrup University Hospital, Glostrup, Denmark
    J Neurosurg 114:1143-53. 2011
    ..The aim in the present study was to determine whether treatment with the MEK1/2 inhibitor U0126 can prevent cerebrovascular receptor upregulation and improve functional outcome after experimental SAH in rats...
  31. ncbi Prevalence and risk factors of neurological disability and impairment in children living in rural Kenya
    V Mung'ala-Odera
    Center for Geographic Medicine Coast, Kenya Medical Research Institute, PO 428, Kilifi, Kenya
    Int J Epidemiol 35:683-8. 2006
    ..There is little data on the burden of neurological impairment (NI) in developing countries, particularly in children of Africa...
  32. ncbi Eph receptors and ephrins in neuron-astrocyte communication at synapses
    Keith K Murai
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal, Canada
    Glia 59:1567-78. 2011
    ..This review will focus on the emerging role of Eph receptors and ephrins in neuron-astrocyte interaction at synapses and discuss implications for synaptic plasticity, behavior, and disease...
  33. ncbi L: -2-Hydroxyglutaric aciduria, a disorder of metabolite repair
    E Van Schaftingen
    de Duve Institute, Universite Catholique de Louvain, Brussels, Belgium
    J Inherit Metab Dis 32:135-42. 2009
    ..Its accumulation is toxic to the mammalian brain, causing a leukoencephalopathy and increasing the susceptibility to develop tumours. L: -2-Hydroxyglutaric aciduria appears to be the first disease of 'metabolite repair'...
  34. ncbi Healthcare tariffs for specialist inpatient neurorehabilitation services: rationale and development of a UK casemix and costing methodology
    Lynne Turner-Stokes
    King s College London School of Medicine, Department of Palliative Care, Policy and Rehabilitation, London, UK
    Clin Rehabil 26:264-79. 2012
    ..To describe the rationale and development of a casemix model and costing methodology for tariff development for specialist neurorehabilitation services in the UK...
  35. ncbi Nanoparticles in the treatment and diagnosis of neurological disorders: untamed dragon with fire power to heal
    Jagat R Kanwar
    Laboratory of Immunology and Molecular Biomedical Research, Centre for Biotechnology and Interdisciplinary Biosciences BioDeakin, Institute for Technology and Research Innovation, Deakin University, Geelong, Victoria, Australia
    Nanomedicine 8:399-414. 2012
    ..In addition, we discuss the integration of bioinformatics and modern genomic approaches in the development of nanoparticles...
  36. ncbi Moderate hypothermia to treat perinatal asphyxial encephalopathy
    Denis V Azzopardi
    Division of Clinical Sciences and Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, Imperial College London, London, United Kingdom
    N Engl J Med 361:1349-58. 2009
    ..Whether hypothermic therapy improves neurodevelopmental outcomes in newborn infants with asphyxial encephalopathy is uncertain...
  37. ncbi Paediatric consequences of fetal growth restriction
    Michael Yanney
    Academic Division of Child Health, Queen s Medical Centre, Floor E, East Block, Nottingham NG7 2UH, UK
    Semin Fetal Neonatal Med 9:411-8. 2004
    ..Children who fail to demonstrate catch-up growth have a high risk of long-term growth problems. There is evidence of impaired growth hormone activity in some children with FGR who have persistent poor growth in the postnatal period...
  38. ncbi Antibodies against GluR3 peptides are not specific for Rasmussen's encephalitis but are also present in epilepsy patients with severe, early onset disease and intractable seizures
    Renato Mantegazza
    Immunology and Muscular Pathology Unit, Istituto Nazionale Neurologico Carlo Besta, Via Celoria 11, Milan, Italy
    J Neuroimmunol 131:179-85. 2002
    ..Antibodies against GluR3B peptide were significantly associated with frequent seizures compared to occasional or drug-controlled seizures...
  39. ncbi Collagens in the developing and diseased nervous system
    T Hubert
    INSERM U 583, Institut des Neurosciences de Montpellier, Hopital Saint Eloi, 80 rue Augustin Fliche, 34091 Montpellier Cedex 5, France
    Cell Mol Life Sci 66:1223-38. 2009
    ..This review summarizes the significant advances which underscore the function and importance of collagens in the nervous system...
  40. ncbi The burden of inpatient neurologic disease in two Ethiopian hospitals
    J H Bower
    Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Neurology 68:338-42. 2007
    ..To define the burden of inpatient neurologic disease seen in Ethiopian teaching hospitals...
  41. ncbi Axon retraction and degeneration in development and disease
    Liqun Luo
    Department of Biological Sciences, Neurosciences Program, Stanford University, Stanford, CA 94305, USA
    Annu Rev Neurosci 28:127-56. 2005
    ..Here we review examples of these phenomena and consider potential cellular and molecular mechanisms that underlie axon retraction and degeneration and how they might relate to each other in development and disease...
  42. ncbi Neuro-Behçet's disease: epidemiology, clinical characteristics, and management
    Adnan Al-Araji
    Neurology Department, University Hospital of North Staffordshire, Stoke on Trent, UK
    Lancet Neurol 8:192-204. 2009
    ..Collaborative prospective studies of the natural history of the disease, particularly the nature and treatment of progressive neurological disease, and evidence-based studies of treatment are needed...
  43. pmc Autonomic dysfunction in dementia
    L M Allan
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    J Neurol Neurosurg Psychiatry 78:671-7. 2007
    ..There are no studies of autonomic function comparing Alzheimer's disease (AD), vascular dementia (VAD), dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD)...
  44. ncbi Neural dysfunction and neurodegeneration in Drosophila Na+/K+ ATPase alpha subunit mutants
    Michael J Palladino
    Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Neurosci 23:1276-86. 2003
    ..Our data show that maintenance of neuronal viability is dependent on normal sodium pump activity and establish Drosophila as a useful model for investigating the role of the pump in human neurodegenerative and seizure disorders...
  45. ncbi Dendritic spine pathology: cause or consequence of neurological disorders?
    John C Fiala
    Department of Biology, Boston University, 5 Cummington Street, MA 02215, USA
    Brain Res Brain Res Rev 39:29-54. 2002
    ..More detailed studies are needed to determine the cause of spine pathology in most disorders and relationship between spine pathology and cognitive deficits...
  46. ncbi An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders
    Dawn L Thiselton
    Department of Molecular Genetics, Institute of Ophthalmology, University College, London, EC1V 9EL, UK
    Genomics 79:560-72. 2002
    ..3-Xp11.23 interval and provides a powerful integrated resource for functional characterization of this clonally unstable, yet gene-rich and clinically significant region of proximal Xp...
  47. ncbi Are abnormal fidgety movements an early marker for complex minor neurological dysfunction at puberty?
    Christa Einspieler
    Institute of Physiology, Center for Physiological Medicine, Medical University of Graz, Harrachgasse 21 5, A 8010 Graz, Austria
    Early Hum Dev 83:521-5. 2007
    ..However, it is uncertain whether the GM assessment can be used to predict mild neurological impairment...
  48. ncbi Health implications of creatine: can oral creatine supplementation protect against neurological and atherosclerotic disease?
    Markus Wyss
    Roche Vitamins AG, Biotechnology Department VFB, Building 203 113A, CH 4070 Basel, Switzerland
    Neuroscience 112:243-60. 2002
    ..g., coronary heart disease or cerebrovascular disease. Although compelling, these results require further confirmation in clinical studies in humans, together with a thorough evaluation of the safety of oral creatine supplementation...
  49. ncbi Neurodevelopmental outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxia
    M R Battin
    Newborn Service, National Women s Hospital, Auckland, New Zealand
    Pediatrics 107:480-4. 2001
    ..To determine the neurodevelopmental outcome of infants treated with head cooling with systemic hypothermia after hypoxic-ischemic encephalopathy...
  50. ncbi Gender differences in neurological disease: role of estrogens and cytokines
    Anna Członkowska
    Institute of Psychiatry and Neurology, Second Department of Neurology, Warsaw, Poland
    Endocrine 29:243-56. 2006
    ....
  51. pmc Neurologic function among termiticide applicators exposed to chlorpyrifos
    K Steenland
    National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA
    Environ Health Perspect 108:293-300. 2000
    ..Although this was a relatively large study based on a well-defined target population, the workers we studied may not be representative of all exposed workers, and caution should be exercised in generalizing our results...
  52. ncbi Cost-efficiency of longer-stay rehabilitation programmes: can they provide value for money?
    Lynne Turner-Stokes
    Regional Rehabilitation Unit, Northwick Park Hospital, Watford Road, Harrow, Middlesex HA1 3UJ, UK
    Brain Inj 21:1015-21. 2007
    ..To examine the cost-efficiency of longer stay rehabilitation in patients with complex neurological disabilities...
  53. ncbi High prevalence of long-term cardiovascular, neurological and psychosocial morbidity after treatment for craniopharyngioma
    Alberto M Pereira
    Department of Endocrinology and Metabolism, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Endocrinol (Oxf) 62:197-204. 2005
    ..The treatment of craniopharyngiomas is associated with long-term morbidity...
  54. ncbi Effects of long-term organophosphate exposures on neurological symptoms, vibration sense and tremor among South African farm workers
    L London
    Department of Community Health, University of Cape Town, Observatory, South Africa
    Scand J Work Environ Health 24:18-29. 1998
    ..This study assessed the relationship between long-term exposure to organophosphate insecticides and neurological symptoms, vibration sense, and motor tremor after control for the effect of past poisoning and acute exposure...
  55. ncbi Behavioral effects of occupational exposure to organophosphorous pesticides in female greenhouse planting workers
    B Bazylewicz-Walczak
    Department of Work Psychology, The Nofer Institute of Occupational Medicine, Lodz, Poland
    Neurotoxicology 20:819-26. 1999
    ..In addition, increased tension, greater depression and fatigue, more frequent symptoms of CNS disturbances were observed in the exposed women compared to the controls...
  56. pmc Alien hand syndrome: neural correlates of movements without conscious will
    Michael Schaefer
    Department of Neurology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    PLoS ONE 5:e15010. 2010
    ..This study aimed to examine neural correlates of this rare neurological disorder in a patient with corticobasal degeneration and alien hand syndrome of the left hand...
  57. ncbi Improved neurodevelopmental outcomes for extremely low birth weight infants in 2000-2002
    Deanne Wilson-Costello
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA
    Pediatrics 119:37-45. 2007
    ..Neurodevelopmental impairment of extremely low birth weight infants increased in the 1990s. Modern therapeutic changes may have influenced more recent neonatal outcomes...
  58. pmc The Rotterdam Study: 2010 objectives and design update
    Albert Hofman
    Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam The Netherlands
    Eur J Epidemiol 24:553-72. 2009
    ..epib.nl/rotterdamstudy). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
  59. ncbi Sequelae after bacterial meningitis in childhood
    Rianne Oostenbrink
    Sophia Children s Hospital, University Hospital Rotterdam, The Netherlands
    Scand J Infect Dis 34:379-82. 2002
    ..Children with bacterial meningitis caused by Streptococcus pneumoniae and those with acute focal neurological symptoms tended to have the worst prognosis...
  60. ncbi Stem cells for the treatment of neurological disorders
    Olle Lindvall
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, SE 221 84 Lund, Sweden
    Nature 441:1094-6. 2006
    ..The next step is to translate these exciting advances from the laboratory into clinically useful therapies...
  61. ncbi The neuroprotective effect of erythropoietin-transduced human mesenchymal stromal cells in an animal model of ischemic stroke
    Goang Won Cho
    Department of Neurology, College of Medicine, Hanyang University, Seongdong Gu, Seoul, Republic of Korea
    Brain Res 1353:1-13. 2010
    ..Transduction of the EPO gene into MSCs induced secretion of EPO and various trophic factors that may provide excellent neuroprotective effects in both in vitro and in vivo models of ischemic stroke...
  62. ncbi Second opinions and tertiary referrals in neurology: a prospective observational study
    L Wieske
    Academic Medical Centre, Dept of Neurology, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Neurol 255:1743-9. 2008
    ..The main purpose of this study was to assess whether a day-care admission made a meaningful contribution to standard neurological outpatient care, for a wide range of second opinions and tertiary referrals...
  63. ncbi Neuroprotection by complement (C1) inhibitor in mouse transient brain ischemia
    M G De Simoni
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Cereb Blood Flow Metab 23:232-9. 2003
    ..Astrocyte activation induced by ischemia was not affected by C1-INH. These findings show that C1-INH displayed a potent neuroprotective action by effectively reducing ischemia-reperfusion injury...
  64. ncbi Prevalence of severe mental and neurological disorders in Mozambique: a population-based survey
    Vikram Patel
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 370:1055-60. 2007
    ..We aimed to assess the prevalence of seizure disorders, psychoses, and mental retardation in urban and rural Mozambique...
  65. ncbi Quality of life of children with neurological impairment who receive a fundoplication for gastroesophageal reflux disease
    Rajendu Srivastava
    University of Utah Health Sciences Center, Salt Lake City, Utah 84113, USA
    J Hosp Med 2:165-73. 2007
    ..Children with neurological impairment (NI) commonly have gastroesophageal reflux disease (GERD) treated with a fundoplication. The impact of this procedure on quality of life is poorly understood...
  66. pmc MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction
    Jannet Kocerha
    Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA
    Proc Natl Acad Sci U S A 106:3507-12. 2009
    ..Taken together, these data support an integral role for miR-219 in the expression of behavioral aberrations associated with NMDA receptor hypofunction...
  67. pmc Induced pluripotent stem cells to model and treat neurogenetic disorders
    Hansen Wang
    Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, ON, Canada
    Neural Plast 2012:346053. 2012
    ....
  68. ncbi Progress and prospects: stem cells and neurological diseases
    S Gogel
    Wolfson Centre for Age Related Diseases, Guy s Campus, King s College London, London, UK
    Gene Ther 18:1-6. 2011
    ....
  69. ncbi The global burden of disease study: implications for neurology
    M Menken
    World Federation of Neurology, Research Group on Medical Education, London, England
    Arch Neurol 57:418-20. 2000
    ..Health ministries worldwide must prioritize neurologic disorders, and neurologists must be prepared to provide care for increased numbers of people individually and in population groups...
  70. ncbi High prevalence of autoantibodies against phosphoglycerate mutase 1 in patients with autoimmune central nervous system diseases
    A Kimura
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan
    J Neuroimmunol 219:105-8. 2010
    ..Results of our study suggest that the anti-PGAM1 antibody is not only a marker of AIH but also a nonspecific marker of central nervous system autoimmune diseases...
  71. ncbi Bullous pemphigoid in a leg affected with hemiparesia: a possible relation of neurological diseases with bullous pemphigoid?
    N Foureur
    Department of Dermatology, Bichat Claude Bernard Hospital, 46, rue Henri Huchard 75018 Paris, France
    Eur J Dermatol 11:230-3. 2001
    ..Bullous pemphigoid could be considered to be a marker of neurological disorder...
  72. pmc Prevalence and patterns of neurological involvement in Behcet's disease: a prospective study from Iraq
    A Al-Araji
    Behcet s Disease Clinic, Baghdad Teaching Hospital and Department of Neurology, College of Medicine, University of Baghdad, Iraq
    J Neurol Neurosurg Psychiatry 74:608-13. 2003
    ....
  73. ncbi Maintenance treatment of glutaryl-CoA dehydrogenase deficiency
    C Mühlhausen
    Departments of Paediatrics, Metabolic Service, University Medical Centers Hamburg, D 20246 Hamburg, Germany
    J Inherit Metab Dis 27:885-92. 2004
    ..g. video documentation) during pharmacotherapy...
  74. pmc Correlation of leukocytosis with early neurological deterioration following supratentorial intracerebral hemorrhage
    Wei Sun
    Duke Clinical Research Institute, Duke University, Durham, NC, USA
    J Clin Neurosci 19:1096-100. 2012
    ..Elevated WBC count appears predictive of deterioration. These data demonstrate that heightened inflammatory state after ICH may be related to early deterioration after injury...
  75. ncbi Neuroradiological findings in glutaric aciduria type I (glutaryl-CoA dehydrogenase deficiency)
    E Neumaier-Probst
    Department of Neuroradiology, University Hospital Mannheim of the University of Heidelberg, D 68167 Mannheim, Germany
    J Inherit Metab Dis 27:869-76. 2004
    ..Based on these findings a suggestion for a MRI protocol is presented, supporting a standardized evaluation of patients with GA I...
  76. ncbi Pseudobulbar affect: an under-recognized and under-treated neurological disorder
    Susan S Work
    Avanir Pharmaceuticals, Inc, 101 Enterprise, Suite 300, Aliso Viejo, CA, 92656, USA
    Adv Ther 28:586-601. 2011
    ..However, the US prevalence of PBA remains unknown...
  77. ncbi Diseases of unstable repeat expansion: mechanisms and common principles
    Jennifer R Gatchel
    Department of Neuroscience, Medical Scientist Training Program, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA
    Nat Rev Genet 6:743-55. 2005
    ..In all these diseases, the context of the expanded repeat and the abundance, subcellular localization and interactions of the proteins and RNAs that are affected have key roles in disease-specific phenotypes...
  78. pmc CNV and nervous system diseases--what's new?
    W Gu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Cytogenet Genome Res 123:54-64. 2008
    ..31 and 15q13.3, as well as their reciprocal duplications, were also identified. In this review, we provide an overview of the phenotypic manifestation of these syndromes and the rearrangements causing them...
  79. ncbi Development of a neuropathic pain questionnaire
    Steven J Krause
    Department of Orthopedics and Rehabilitation Medicine, University of Wisconsin, Madison, Wisconsin, USA
    Clin J Pain 19:306-14. 2003
    ..Consequently, it can be used for monitoring of neuropathic pain treatments and as an outcome measure...
  80. ncbi Neurologic manifestations of the cryopyrin-associated periodic syndrome
    Joanna L Kitley
    Wessex Neurological Centre, Southampton General Hospital, UK
    Neurology 74:1267-70. 2010
    ..Neurologic complications are common in children with the chronic infantile, neurologic, cutaneous, and articular phenotype, but there are no previous published reports of neurologic features in adults with milder phenotypes...
  81. pmc Electroacupuncture pretreatment induces tolerance against focal cerebral ischemia through activation of canonical Notch pathway
    Yu Zhao
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    BMC Neurosci 13:111. 2012
    ..In the present study, we tested the hypothesis that EA pretreatment-induced tolerance against focal cerebral ischemia is mediated by Notch signaling...
  82. ncbi Roles of trinucleotide-repeat RNA in neurological disease and degeneration
    Ling Bo Li
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Trends Neurosci 33:292-8. 2010
    ..Greater understanding of these mechanisms will provide the foundation for therapeutic advances for this set of human disorders...
  83. ncbi Clinical characteristics of pediatric-onset neuro-Behçet disease
    D Uluduz
    Department of Neurology and Division of Rheumatology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey
    Neurology 77:1900-5. 2011
    ..Neurologic involvement in the pediatric population with Behçet disease (BD) is limited to case reports. The aim of this study is to examine the frequency and type of neurologic involvement in pediatric patients with BD...
  84. ncbi Neurological manifestations of enterovirus 71 infection in children during an outbreak of hand, foot, and mouth disease in Western Australia
    P McMinn
    Department of Microbiology, Princess Margaret Hospital for Children, Perth, WA, Australia
    Clin Infect Dis 32:236-42. 2001
    ..This finding is in contrast to reports of previous EV71 epidemics, in which virus-induced damage to gray matter was the most frequent cause of neurological disease...
  85. pmc Preclinical assessment of stem cell therapies for neurological diseases
    Valerie L Joers
    Neuroscience Training Program, University of Wisconsin, Madison, WI, USA
    ILAR J 51:24-41. 2009
    ..We also discuss the relationship between the limited number of systematic stem cell studies performed in animals, in particular nonhuman primates and the delayed progress in advancing stem cell therapies to clinical success...
  86. pmc Reflux related hospital admissions after fundoplication in children with neurological impairment: retrospective cohort study
    Rajendu Srivastava
    Division of Inpatient Medicine, Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    BMJ 339:b4411. 2009
    ..To examine the impact of fundoplication on reflux related hospital admissions for children with neurological impairment...
  87. ncbi Glutamate NMDA receptors in pathophysiology and pharmacotherapy of selected nervous system diseases
    Lukasz Dobrek
    Department of Pathophysiology, Jagiellonian University Medical College Cracow, Poland
    Postepy Hig Med Dosw (Online) 65:338-46. 2011
    ..It also reviews the current and potential future status of agents targeting NMDARs in neuropsychopharmacology...
  88. ncbi A visual skills inventory for children with neurological impairments
    D L McCulloch
    Vision Sciences, Glasgow Caledonian University, Glasgow, Scotland, UK
    Dev Med Child Neurol 49:757-63. 2007
    ..Evaluation of visual skills in children with neurological impairment can provide valid information about the quality of children's vision. Questions with the highest validity for predicting vision are identified...
  89. ncbi Neurologic effects of manganese in humans: a review
    Barry S Levy
    P O Box 1230, Sherborn, Massachusetts, 01770USA
    Int J Occup Environ Health 9:153-63. 2003
    ..More recently, there have been epidemiologic studies of its adverse effects on health. Occupational medicine physicians can play critical roles in preventing the adverse health effects of manganese...
  90. ncbi Essential infantile esotropia in neurologically impaired pediatric patients: is botulinum toxin better primary treatment than surgery?
    Veronica Hauviller
    Hospital de Niños R Gutiérrez, Buenos Aires, Argentina
    Binocul Vis Strabismus Q 22:221-6. 2007
    ..Mean age was 26.4 months, (range 9-76 months) and mean initial angle was 35 prism diopters (PD)(range 20-60 PD)...
  91. ncbi Neurological symptoms among Sri Lankan farmers occupationally exposed to acetylcholinesterase-inhibiting insecticides
    Lidwien A M Smit
    International Water Management Institute, Colombo, Sri Lanka
    Am J Ind Med 44:254-64. 2003
    ..In many agricultural districts in Sri Lanka, pesticide poisoning is a leading cause of death. This study aims to evaluate the impact of pesticide use on Sri Lankan farmers' health...
  92. ncbi Pathological laughing and crying : epidemiology, pathophysiology and treatment
    Hal S Wortzel
    Brain Injury Rehabilitation Unit, HealthONE Spalding Rehabilitation Hospital, Aurora, Colorado, USA
    CNS Drugs 22:531-45. 2008
    ....
  93. pmc NGG-triplet repeats form similar intrastrand structures: implications for the triplet expansion diseases
    K Usdin
    Section on Genomic Structure and Function, Laboratory of Molecular and Cellular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0830, USA
    Nucleic Acids Res 26:4078-85. 1998
    ....
  94. ncbi D-2-hydroxyglutaric aciduria in a newborn with neurological abnormalities: a new neurometabolic disorder?
    K M Gibson
    Metabolic Disease Center, Baylor Research Institute, Dallas, Texas, USA
    J Inherit Metab Dis 16:497-500. 1993
  95. ncbi Developmental neurotoxicity evaluation of the avermectin pesticide, emamectin benzoate, in Sprague-Dawley rats
    L D Wise
    Merck Research Laboratories, Department of Safety Assessment, West Point, PA 19486, USA
    Neurotoxicol Teratol 19:315-26. 1997
    ..6 mg/kg/day...
  96. ncbi Computerized tomography scan of the brain in a community study of neurological impairment in Kenya
    P W Njuguna
    Centre for Geographic and Medical Research, Kenya Medical Research Institute, Kilifi, Kenya
    J Child Neurol 22:26-32. 2007
    ..29 of 1000. Motor impairments were more likely to show abnormality than the other indications. CT abnormalities are common in children with neurological impairment in Kenya, but the appearances did not identify a major cause...
  97. ncbi Predictors of long term neurological outcome in bacterial meningitis
    Pratibha Singhi
    Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Indian J Pediatr 74:369-74. 2007
    ..To study the long-term neurological and developmental outcome and the clinical and laboratory predictors of sequelae in children with acute bacterial meningitis (ABM)...
  98. ncbi Assessing the effects of environmental toxicant exposure in developmental epidemiological studies: issues for risk assessment
    Deborah C Rice
    Environmental Health Unit, Maine Bureau of Health, State House Station 11, Augusta, ME 04333, USA
    Neurotoxicology 26:483-9. 2005
    ..Opportunity for discussion among investigators, statisticians, and risk assessors potentially would result in human developmental toxicity studies being maximally useful for public health decisions...
  99. ncbi Clinical course of cranial dural arteriovenous fistulas with long-term persistent cortical venous reflux
    J Marc C van Dijk
    Division of Neurosurgery and Division of Neuroradiology, University of Toronto Brain Vascular Malformations Study Group, Toronto, Ontario, Canada
    Stroke 33:1233-6. 2002
    ..A consecutive single-center cohort of 236 cases that presented with a cranial DAVF between June 1984 and May 2001 was reviewed for the consequences of long-term persistent cortical venous reflux (CVR)...
  100. ncbi Analysis of human neurological disorders using mutagenesis in the mouse
    Peter L Oliver
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Clin Sci (Lond) 108:385-97. 2005
    ....
  101. ncbi Astrocyte dysfunction in neurological disorders: a molecular perspective
    Gerald Seifert
    Department of Experimental Neurobiology, Clinic of Neurosurgery, University of Bonn, Germany
    Nat Rev Neurosci 7:194-206. 2006
    ..An improved understanding of astrocyte biology and heterogeneity and the involvement of these cells in pathogenesis offers the potential for developing novel strategies to treat neurological disorders...

Research Grants76

  1. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  2. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..Transplantation/methods/*trends</keyword;keyword>Central Nervous System Diseases/*therapy</keyword;keyword>Cerebrovascular Accident/therapy</keyword;keyword>Clinical Trials&..
  3. Chronic nicotine and synaptic transmission in brainstem respiratory neurons
    RALPH FRANK FREGOSI; Fiscal Year: 2013
    ..It is therefore crucial to begin establishing the mechanisms that lead to abnormal development of the brainstem neurons that regulate these critical homeostatic functions. ..
  4. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
    ....
  5. Epigenetics of Sex Differences in Brain and Behavior
    BRIDGET NUGENT; Fiscal Year: 2012
    ....
  6. Tat and CDK9 on gene expression alterations coupled to HIV-1 Associated Dementia
    Xavier Grana; Fiscal Year: 2010
    ....
  7. Cre, Dre Dual Lineage Model for Calcium Imaging and Optogenetic Manipulations
    Petr Tvrdik; Fiscal Year: 2013
    ..We will be able to determine if Hoxb8 mutant microglia respond to neural stimuli correctly. Taken together, the proposed work will advance the set of tools available to address the underlying causes of glial and other disorders. ..
  8. Regulation of AKAP79 Postsynaptic Membrane Targeting
    MARK L DELL'ACQUA; Fiscal Year: 2012
    ....
  9. Ethanol Regulation of Serum Glucocorticoid Kinase I
    BLAIR N COSTIN; Fiscal Year: 2012
    ..The work proposed here could shed light on molecular mechanisms underlying alcoholism and eventually have implications in the development of novel pharmacological agents for alcoholism or alcohol-related neurological disorders. ..
  10. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2013
    ..Our research will help understand the mechanisms by which synapses form and bring us closer to identifying the molecular deficits in individuals with autism and mental retardation. ..
  11. Drug Interactions at the Human Blood-Brain Barrier
    Jashvant D Unadkat; Fiscal Year: 2010
    ..In addition, our studies will measure the magnitude of such interactions. The results of our study should lead to better management of drug therapy and improvement of the drug development process. ..
  12. Emergency Neurophysiological Assessment Bedside Logic Engine
    Don M Tucker; Fiscal Year: 2010
    ..Network access technology will facilitate remote review by expert neurologists, and a training protocol will provide first-responder usability for emergency technicians and physicians without training in clinical neurophysiology. ..
  13. Exome re-sequencing candidate loci for familial essential tremor
    Barry E Kosofsky; Fiscal Year: 2012
    ..Studying the untoward effects of mutant ET genes will increase our knowledge of ET and other movement disorders such as Parkinson disease. ..
  14. Characterization of epsilon-sarcoglycan interacting proteins in mouse brain
    Yuqing Li; Fiscal Year: 2012
    ..The results should significantly increase our understanding of the pathophysiology of M-D, which can ultimately aid the development of therapeutic treatments for M-D patients and other dystonia and myoclonus patients. ..
  15. Dynamics of Kinesins, Dyneins, and Myosins
    Paul R Selvin; Fiscal Year: 2010
    ..as a function of insertion length of the cargo-binding domain of myosin VI (with L. Sweeney, UPenn.). d) Technological developments: Optics/microscopy needs to be achieved to fulfill the above goals. ..
  16. Mechanism of Age-Related Change in Estrogen Receptor Beta Expression in Rat Brain
    JENNE MITCHELL WESTBERRY; Fiscal Year: 2012
    ..Furthermore, we will develop a new methodology that will be critical for examining epigenetic changes in gene expression in a temporal and spatial manner in neural tissue with heterogeneous cell populations. ..
  17. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012
    ....
  18. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    John R Grider; Fiscal Year: 2013
    ..The results would open a new field of study and point the way to new avenues of investigation for pharmacological agents to treat diarrhea and/or constipation. ..
  19. Chromatin Modifications and Vulnerability to Glutamate Toxicity
    ALEXEI D KONDRATYEV; Fiscal Year: 2010
    ..This proposal will examine these mechanisms and will lay the foundation for identification of new targets for therapy of a broad variety of neurological conditions relevant to excitotoxicity. ..
  20. Brain Delivery of Nanoformulated Superoxide Dismutase
    Erin G Rosenbaugh; Fiscal Year: 2013
    ..In addition to the proposed scientific research, this fellowship will support the applicant's participation in nanotechnology-based coursework and career development. ..
  21. RNA interference therapy for Huntington's disease: studies in non-human primates
    Beverly L Davidson; Fiscal Year: 2010
    ..This work is a collaborative effort between laboratories at the University of Iowa and the Oregon National Primate Research Center at the Oregon Health Sciences University. ..
  22. MECHANISMS OF DENDRITE MORPHOGENESIS BY THE ANAPHASE-PROMOTING COMPLEX
    ALBERT HONG JAE KIM; Fiscal Year: 2013
    ....
  23. The Role of the Terminal Complement Pathway in ALS
    Scott R Barnum; Fiscal Year: 2013
    ..system, drives neuroinflammation along with other inflammatory mediators in most, if not all, central nervous system diseases and infections. There is growing evidence that complement contributes to neurodegeneration in ALS...
  24. Pharmacological strategies to improve breathing after cervical spinal cord injury
    FRANCIS GOLDER; Fiscal Year: 2009
    ..To this end, we propose investigating a promising pharmacological approach that persistently increases respiratory motoneuron function, thereby improving breathing after spinal cord injury. ..
  25. Ephrin-A3 in Neuron-Glia Communication
    Elena B Pasquale; Fiscal Year: 2011
    ..Strategies to manipulate ephrin function in glial cells could help treatment of neurological disorders involving aberrant neuron-glia interactions in the hippocampus and other regions of the nervous system. ..
  26. Optimization of EphA4 antagonists for CNS disorders
    ELENA B contact PASQUALE; Fiscal Year: 2010
    ..The optimized antagonists will be useful to further study the physiological and pathological functions of EphA4 and may serve as starting points for drug development to treat disorders of the nervous system. ..
  27. Endothelial-reactive antibodies: a diagnostic test for Susac's syndrome
    WILLIAM JAMES WALDMAN; Fiscal Year: 2011
    ..The goal of this project is the development of such a test, which would facilitate prompt treatment and thus prevent or minimize residual defects associated with the disease. ..
  28. The Transcobalamin Receptor in Cobalamin Homeostasis
    Edward V Quadros; Fiscal Year: 2011
    ..abstract_text> ..
  29. Modeling schizophrenia gamma deficits using cell-specific RNAi knockdown of GAD67
    RITCHIE EDWARD BROWN; Fiscal Year: 2012
    ....
  30. Regulation of HIV-1 by Rad51 in CNS cells
    Kamel Khalili; Fiscal Year: 2013
    ..The identification of novel host-viral interaction pathways can provide important information regarding the pathogenesis of AIDS/CNS disease and promote the development of more effective therapeutic strategies. ..
  31. DNA methylation alterations in response to pesticides exposure
    Lifang Hou; Fiscal Year: 2010
    ..The results from this study will address a critical gap in our knowledge of pesticides and their ability to cause cancer. ..
  32. Astrocytes Play a Critical Role in the Pathology of EAE
    JOHN ROLAND BETHEA; Fiscal Year: 2013
    ..Ultimately, our goal is to determine if interfering with these responses could be beneficial as a therapeutic strategy for MS and other neurological disorders. ..
  33. Optimization of HDAC6 Inhibitors in the Treatment of CMT
    Ludo Van Den Bosch; Fiscal Year: 2013
    ....
  34. Enzymology of Post-translational Modifications
    Carol A Fierke; Fiscal Year: 2013
    ..Identification of the protein substrates and downstream biological function will enhance the development of new therapeutics targeting these pathways. ..
  35. Ligand Interaction of Glucagon Receptor by Structural and Functional Analyses
    FAI YIU SIU; Fiscal Year: 2012
    ....
  36. Improving CBF through direct control of CSF pulsations
    MARK GREGORY LUCIANO; Fiscal Year: 2010
    ....
  37. Identification of Inhibitors that Stabilize ER Degradation Substrates
    Domenico Tortorella; Fiscal Year: 2012
    ..These inhibitors would be effective agents against genetic disorders caused by misfolded ER proteins and pathogens that utilize the ERAD pathway. ..
  38. Mechanisms Underlying Social Cooperative Behavior
    LUKE JOSEPH CHANG; Fiscal Year: 2010
    ....
  39. Response of Rhesus Sperm to Freezing: Recovery from Osmotic and Oxidative Stress
    Stuart A Meyers; Fiscal Year: 2010
    ....
  40. Neurorestorative Strategy for Diabetic Peripheral Neuropathy
    Feng Qiao Li; Fiscal Year: 2013
    ..2) To determine if COG112 exerts neuroprotective and neurorestorative effects in vivo by functional and histological examination in a DPN model of BKS db/db mice. ..
  41. Development and Regulation of Cholinergic Synapses
    Andres Villu Maricq; Fiscal Year: 2013
    ....
  42. Subunit dependent properties of kainate receptors
    David D Mott; Fiscal Year: 2013
    ..A better understanding of kainate receptor properties is essential in the rational development of novel therapeutic agents targeted at these receptors. ..
  43. Noncoding RNAs as epigenomic modulators in Alzheimer's Disease
    CLAES ROBERT WAHLESTEDT; Fiscal Year: 2010
    ..However, these genetic causes are at least in part atypical (nonconventional), and we therefore argue that so-called "epigenetic/epigenomic" causes must be considered. ..
  44. Genetic Mapping Of Novel Molecular Players in Itch
    RACHEL BETH BREM; Fiscal Year: 2013
    ..Identification of candidate itch factors will provide new targets for development of drugs and therapies to treat intractable itch. ! ..
  45. Distance-Dependent Structure and Function of Neuronal Dendrites
    Kristen M Harris; Fiscal Year: 2013
    ..Investigative tools will be improved to measure core subcellular structures regulate synaptic load, especially during long-term potentiation, a well-studied cellular mechanism of learning and memory. ..
  46. Small Molecule Probes for TAR DNA Binding Protein 43_TDP-43
    Allen B Reitz; Fiscal Year: 2012
    ....
  47. Distance-Dependent Structure and Function of Neuronal Dendrites
    Kristen M Harris; Fiscal Year: 2010
    ....
  48. ATM, REACTIVE OXYGEN, AND CELLULAR RESPONSES TO HYPOXIA
    MICHAEL BARRY KASTAN; Fiscal Year: 2013
    ..New insights gained could be beneficial not only to this patient population, but could also benefit patients with cancer, cardiovascular disease, and neurological disorders. ..
  49. Fine-Tuning the Notch Signaling Pathway via O-Glucosylation
    Hamed Jafar-Nejad; Fiscal Year: 2013
    ..In this proposal we will characterize how addition of glucose residues to the Notch protein fine-tunes signaling mediated by this important pathway. ..
  50. HIV-CNS Diseases and Parasitic Zoonoses in the Eastern Cape, South Africa
    HELENE CARABIN; Fiscal Year: 2010
    ..Learning more about the parasitic infection/HIV interaction could better prevent neurological disease in people with HIV. ..
  51. Early Identification of Developmental Disorders in Infants
    B Eugene Parker; Fiscal Year: 2012
    ....
  52. Small-molecule probes of chromatin-mediated neuroplasticity
    Stephen J Haggarty; Fiscal Year: 2013
    ..These multidisciplinary studies will shed new light on molecular mechanisms of brain plasticity and the relevance of these mechanisms to the development of novel therapeutics for their treatment of memory and mood disorders. ..
  53. Translational refinement of adaptive communication system for locked-in patients
    Melanie Fried-Oken; Fiscal Year: 2013
    ..The proposed project stresses the translation of basic computer science into clinical care, supporting the proposed NIH Roadmap and public health initiatives. ..
  54. Hypocretin and Locus Ceruleus Interactions in Zebrafish Development and Behavior
    Grigorios Oikonomou; Fiscal Year: 2012
    ..This proposal aims to investigate the physical connections between these two centers, how these connections are formed during development and how these systems interact with each other to regulate sleep/wake behaviors. ! ..
  55. WHOLE SLIDE IMAGING SYSTEM FOR TRANSLATIONAL NEUROSCIENCE
    Jin Moo Lee; Fiscal Year: 2010
    ..Data sharing provides great dividends by facilitating comparisons between disease models, and allowing new research findings on existing data without having to perform additional animal experiments. ..
  56. Targeted DNA Nanoparticles in Brain
    David M Yurek; Fiscal Year: 2010
    ..Successful results from our animal studies could then be translated to human studies using these targeted nanoparticles as a form of non-viral, gene therapy to treat various neurological disorders. ..
  57. Astrocyte Function and Temporal Lobe Epilepsy
    JAY ROBERT VARGAS; Fiscal Year: 2010
    ..It is anticipated that this work will reveal new potential therapeutic targets for the treatment of epilepsy. ..
  58. Unifying Mechanisms of Neurological Disorders: Scientific, Translational, and Cli
    JOAN MARIE CRANMER; Fiscal Year: 2010
    ..NEUROTOXICOLOGY 26 will focus on common mechanisms in neurological disease and the role of environmental exposures and gene-environment interactions in the development of neurological disease and disorders. ..
  59. Training in Environmental Health to Reduce Chronic Disease in Latin America
    Philip J Landrigan; Fiscal Year: 2013
    ..This program will provide training in the identification, prevention, research, and treatment pediatric environmental health for Latin American health care providers and scientists. ..
  60. Inflammation-Induced Behavioral Alterations: A Psychogenomic Approach
    SANDRA L RODRIGUEZ ZAS; Fiscal Year: 2013
    ....
  61. Regulation of Synapse Morphogenesis in Drosophila
    David L Van Vactor; Fiscal Year: 2013
    ..We will determine the strategy by which Drosophila miR-8 promotes synapse formation as a model to better define the logic of pathways upstream and downstream of synaptic microRNAs. ..
  62. Elucidating the role of the eIF2alpha kinase PERK in synaptic plasticity and memo
    MY AI TRINH; Fiscal Year: 2010
    ....
  63. Bladder Voiding via Pudendal Nerve Block
    KENNETH GUSTAFSON; Fiscal Year: 2009
    ..In addition, the substantial potential future clinical impact from HF nerve block to a number of other clinical applications, such as chronic pain, muscle spasticity, etc. increases the value of this work. ..
  64. GABA-A Receptor Gene Transfer to Prevent Epileptogenesis
    SHELLEY RUSSEK; Fiscal Year: 2004
    ..abstract_text> ..
  65. Glial Dysfunction in Ataxia Telangiectasia
    Margot Mayer Proschel; Fiscal Year: 2009
    ..We propose experiments that would provide an entirely new strategy to the treatment of AT. ..
  66. A finger-prick medical diagnostic for vitamin B12 malabsorption: An early interv
    STEPHEN DUEKER; Fiscal Year: 2006
    ..The work is significant as it would lead to a needed convenient diagnostic test for the clinical B12 malabsorption that can be employed in the clinic or in research settings. [unreadable] [unreadable] [unreadable]..
  67. Borrelia lipoproteins with the cerebral microcirculation
    Diego Cadavid; Fiscal Year: 2007
    ..2. Investigate whether Vspl enters BMEC. 3. Determine whether Vspl crosses BMEC barriers. 4. Identify the structural features that mediate the interaction of Vspl with BMEC. [unreadable] [unreadable]..
  68. LTQ Orbitrap XL ETD Mass Spectrometer
    Haining Zhu; Fiscal Year: 2010
    ..The requested instruments are environmentally friendly. In summary, the funding of this application will make the United States and the world healthier, cleaner and safer. ..
  69. REGULATION OF SODIUM CHANNEL EXPRESSION
    ROBERT MAUE; Fiscal Year: 2000
    ....
  70. Brain H2D MRS: Implemation and Initial Applications
    Zhiyue Wang; Fiscal Year: 2004
    ..2D MRS will also be used to characterize unusual peaks found in clinical practice. ..
  71. 7th National Headache Foundation Research Summit
    Rima Dafer; Fiscal Year: 2009
    ....
  72. BIOGENIC AMINES AND NEUROLOGICAL DISORDERS
    Robert Katzman; Fiscal Year: 1980
    ..We will study the effect upon symptomatology and CSF metabolites in these diseases of various drugs that act on dopaminergic, cholinergic, or serotonergic systems. ..
  73. Cerebral Malaria Associated Neurological Disorders in India
    Jonathan Stiles; Fiscal Year: 2005
    ..Data from the proposed research will reveal t he molecular basis of cerebral malaria induced neurological and cognitive impairment. ..
  74. A finger-prick medical diagnostic for vitamin B12 malabsorption - An early interv
    STEPHEN DUEKER; Fiscal Year: 2009
    ..The work is significant as it would lead to a needed convenient diagnostic test for B12 malabsorption that can be employed in the clinic or in research settings. ..
  75. Development and Translational Assesment of a Tongue-Based Assistive Neuro-Technol
    Maysam Ghovanloo; Fiscal Year: 2010
    ..We further develop TDS and evaluate it by individuals with severe disabilities. ..
  76. Clinical Trial of Ceftriaxone in ALS
    Merit Cudkowicz; Fiscal Year: 2004
    ..Secondary outcome measures will include ALSFRS-R, vital capacity, strength, and the long-term safety and tolerability of ceftriaxone in this population. ..