second primary neoplasms

Summary

Summary: Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.

Top Publications

  1. ncbi Sarcoma as a second malignancy after treatment for breast cancer
    Johnny Yap
    Department of Radiation Oncology, Wayne State University School of Medicine, Detroit, MI, USA
    Int J Radiat Oncol Biol Phys 52:1231-7. 2002
  2. ncbi Second primary neoplasms in 633,964 cancer patients in Sweden, 1958-1996
    C Dong
    Department of Biosciences at Novum, CNT Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Int J Cancer 93:155-61. 2001
  3. ncbi Risk of second primary malignancies in patients with cutaneous melanoma
    M H Schmid-Wendtner
    Department of Dermatology and Allergology, Klinikum Innenstadt, Ludwiq Maximilians University, Munich, Germany
    Br J Dermatol 145:981-5. 2001
  4. ncbi Familial carcinoid tumors and subsequent cancers: a nation-wide epidemiologic study from Sweden
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 94:444-8. 2001
  5. ncbi Second malignant neoplasms in five-year survivors of childhood cancer: childhood cancer survivor study
    J P Neglia
    Department of Pediatrics, University of Minnesota School of Medicine, 420 Delaware St, Minneapolis, MN 55455, USA
    J Natl Cancer Inst 93:618-29. 2001
  6. ncbi Mechanisms of therapy-related carcinogenesis
    James M Allan
    Epidemiology and Genetics Unit, Department of Biology, University of York, Heslington, York, YO10 5YW, UK
    Nat Rev Cancer 5:943-55. 2005
  7. ncbi Second malignancy after Hodgkin disease treated with radiation therapy with or without chemotherapy: long-term risks and risk factors
    Andrea K Ng
    Department of Radiation Oncology and the Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Blood 100:1989-96. 2002
  8. ncbi Does solar exposure, as indicated by the non-melanoma skin cancers, protect from solid cancers: vitamin D as a possible explanation
    Pentti Tuohimaa
    Medical School, Department of Clinical Chemistry, University of Tampere, Tampere University Hospital, Tampere 33014, Finland
    Eur J Cancer 43:1701-12. 2007
  9. ncbi Long-term cause-specific mortality of patients treated for Hodgkin's disease
    Berthe M P Aleman
    Department of Epidemiology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Clin Oncol 21:3431-9. 2003
  10. ncbi Second cancers occurring in patients with early stage non-small-cell lung cancer treated with chest radiation therapy alone
    B Jeremic
    Department of Oncology, University Hospital, Kragujevac, Yugoslavia
    J Clin Oncol 19:1056-63. 2001

Detail Information

Publications360 found, 100 shown here

  1. ncbi Sarcoma as a second malignancy after treatment for breast cancer
    Johnny Yap
    Department of Radiation Oncology, Wayne State University School of Medicine, Detroit, MI, USA
    Int J Radiat Oncol Biol Phys 52:1231-7. 2002
    ..Using data from the Surveillance, Epidemiology and End Results registries, we evaluated the influence of radiation therapy on the development of subsequent sarcomas in cases with primary breast cancer...
  2. ncbi Second primary neoplasms in 633,964 cancer patients in Sweden, 1958-1996
    C Dong
    Department of Biosciences at Novum, CNT Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Int J Cancer 93:155-61. 2001
    ..Swedish Family-Cancer Database was used to analyze concordant (same site) and discordant (different site) second primary neoplasms in 633,964 cancer patients diagnosed from 1958 to 1996...
  3. ncbi Risk of second primary malignancies in patients with cutaneous melanoma
    M H Schmid-Wendtner
    Department of Dermatology and Allergology, Klinikum Innenstadt, Ludwiq Maximilians University, Munich, Germany
    Br J Dermatol 145:981-5. 2001
    ..In several studies an increased risk for development of breast cancer, malignant lymphoma and neoplasms of the kidney as second primary cancers in patients with cutaneous melanomas was discussed...
  4. ncbi Familial carcinoid tumors and subsequent cancers: a nation-wide epidemiologic study from Sweden
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Int J Cancer 94:444-8. 2001
    ..Risks for second cancers were increased, particularly at sites where familial risks were found, including carcinoids in the small intestine...
  5. ncbi Second malignant neoplasms in five-year survivors of childhood cancer: childhood cancer survivor study
    J P Neglia
    Department of Pediatrics, University of Minnesota School of Medicine, 420 Delaware St, Minneapolis, MN 55455, USA
    J Natl Cancer Inst 93:618-29. 2001
    ..Using the Childhood Cancer Survivor Study cohort, we identified the risk of SMNS:..
  6. ncbi Mechanisms of therapy-related carcinogenesis
    James M Allan
    Epidemiology and Genetics Unit, Department of Biology, University of York, Heslington, York, YO10 5YW, UK
    Nat Rev Cancer 5:943-55. 2005
    ..Unsurprisingly, some of these mechanisms seem to operate in the development of sporadic cancers...
  7. ncbi Second malignancy after Hodgkin disease treated with radiation therapy with or without chemotherapy: long-term risks and risk factors
    Andrea K Ng
    Department of Radiation Oncology and the Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Blood 100:1989-96. 2002
    ..Our analysis suggests that the risk may be reduced with smaller radiation fields, as are used in current trials of abbreviated chemotherapy and limited-field radiation therapy...
  8. ncbi Does solar exposure, as indicated by the non-melanoma skin cancers, protect from solid cancers: vitamin D as a possible explanation
    Pentti Tuohimaa
    Medical School, Department of Clinical Chemistry, University of Tampere, Tampere University Hospital, Tampere 33014, Finland
    Eur J Cancer 43:1701-12. 2007
    ..The aim of this study was to assess whether patients with skin cancer have an altered risk of developing other cancers...
  9. ncbi Long-term cause-specific mortality of patients treated for Hodgkin's disease
    Berthe M P Aleman
    Department of Epidemiology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Clin Oncol 21:3431-9. 2003
    ..To assess long-term cause-specific mortality of young Hodgkin's disease (HD) patients...
  10. ncbi Second cancers occurring in patients with early stage non-small-cell lung cancer treated with chest radiation therapy alone
    B Jeremic
    Department of Oncology, University Hospital, Kragujevac, Yugoslavia
    J Clin Oncol 19:1056-63. 2001
    ..To investigate the incidence of second cancers occurring in patients with early stage (I/II) non-small-cell lung cancer (NSCLC) treated with radiation therapy (RT) alone...
  11. ncbi Radiation-induced sarcomas after radiotherapy for breast carcinoma: a large-scale single-institution review
    Youlia M Kirova
    Department of Radiation Oncology, Institut Curie, Paris, France
    Cancer 104:856-63. 2005
    ..Sarcomas are a rare complication of radiotherapy for breast carcinoma and patients have a poor prognosis. The incidence, histology, and management of patients with sarcomas were reviewed in the current study...
  12. ncbi Familial testicular cancer and second primary cancers in testicular cancer patients by histological type
    C Dong
    Department of Biosciences at Novum, Karolinska Institute, 141 57, Huddinge, Sweden
    Eur J Cancer 37:1878-85. 2001
    ..Our data support the contention that genetic predisposition is one of the major contributors to familial and multiple testicular cancers...
  13. ncbi Risk of new primary nonbreast cancers after breast cancer treatment: a Dutch population-based study
    Michael Schaapveld
    Comprehensive Cancer Center North Netherlands CCCN, P O Box 330, 9700 AH Groningen, The Netherlands
    J Clin Oncol 26:1239-46. 2008
    ..To assess the risk of secondary nonbreast cancers (SNBCs) in a recently treated population-based cohort of breast cancer patients focused on the association with treatment and prognostic implications...
  14. ncbi Cancer survivorship--genetic susceptibility and second primary cancers: research strategies and recommendations
    Lois B Travis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Natl Cancer Inst 98:15-25. 2006
    ..These research areas warrant high priority to promote NCI's goal of eliminating pain and suffering related to cancer...
  15. ncbi Second cancers after breast cancer treatment
    Sister Mary Andrew Matesich
    Ohio Dominican College, Columbus, USA
    Semin Oncol 30:740-8. 2003
    ..Additional studies are needed to more precisely identify patients who are or are not likely to benefit from adjuvant therapy, and individual host and treatment factors that influence the development of second cancer...
  16. ncbi The effect of intensity-modulated radiotherapy on radiation-induced second malignancies
    Jeremy D Ruben
    William Buckland Radiotherapy Centre, Melbourne, Australia Monash University, Melbourne, Australia
    Int J Radiat Oncol Biol Phys 70:1530-6. 2008
    ..To compare intensity-modulated radiotherapy (IMRT) with three-dimensional conformal radiotherapy (3D-CRT) in terms of carcinogenic risk for actual clinical scenarios...
  17. ncbi Cancer incidence after localized therapy for prostate cancer
    Kihyuck Moon
    Department of Urology, University of Virginia, Charlottesville, Virginia 22908, USA
    Cancer 107:991-8. 2006
    ..In this study, the authors examined the size and significance of the observed association between occurrences of secondary cancers 5 years after radiotherapy in a large population of men with incident prostate cancer...
  18. pmc Second malignant neoplasms after a first cancer in childhood: temporal pattern of risk according to type of treatment
    F de Vathaire
    Research Unit of Cancer Epidemiology U351 INSERM, Institut Gustave Roussy, Villejuif, France
    Br J Cancer 79:1884-93. 1999
    ..When compared with radiotherapy alone, the addition of chemotherapy increases the risk of solid SMN after a first cancer in childhood, but does not significantly modify the variation of this risk during the time after the first cancer...
  19. pmc Second primary neoplasms following non-Hodgkin's lymphoma in New South Wales, Australia
    P Brennan
    International Agency for Research on Cancer, Lyon, France
    Br J Cancer 82:1344-7. 2000
    ..We used data from the New South Wales Central Cancer Registry to analyse second primary neoplasms following NHL diagnosed between 1972 and 1995, to identify possible common causal agents...
  20. ncbi Risk of second primary cancer in the contralateral breast in women treated for early-stage breast cancer: a population-based study
    Xiang Gao
    Central Arkansas Radiation Therapy Institute, Little Rock, AR 72215, USA
    Int J Radiat Oncol Biol Phys 56:1038-45. 2003
    ..To study the potential risk factors, including radiotherapy (RT) for contralateral breast cancer (CBC), in patients treated for early-stage breast cancer...
  21. ncbi The risk of secondary malignancies over 30 years after the treatment of non-Hodgkin lymphoma
    Jonathan D Tward
    Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah, Salt Lake City, Utah 84112 5560, USA
    Cancer 107:108-15. 2006
    ..Survivors of non-Hodgkin lymphoma (NHL) are at increased risk for developing secondary malignancies. For the current study, the authors quantitated this risk in a group of NHL survivors over 30 years of follow-up...
  22. pmc Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study
    K Schmiegelow
    The Institute of Gynecology, Obstetrics, and Pediatrics, The Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark
    Leukemia 23:557-64. 2009
    ..These data suggest that children with ALL and TPMT wild type might have their cure rate improved, if the pharmacokinetics/-dynamics of TPMT low-activity patients could be mimicked without a concurrent excessive risk of second cancers...
  23. ncbi Cumulative absolute breast cancer risk for young women treated for Hodgkin lymphoma
    Lois B Travis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Natl Cancer Inst 97:1428-37. 2005
    ..We estimated this future risk, taking into account age and calendar year of HL diagnosis, HL treatment information, population breast cancer incidence rates, and competing causes of death...
  24. ncbi Skin cancer and non-Hodgkin's lymphoma as second malignancies. markers of impaired immune function?
    K Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Eur J Cancer 39:223-9. 2003
    ..0 for Hodgkin's disease; 3.6 for UADT as the first site). The high, and after certain sites, very high risks of second skin cancer and non-Hodgkin's lymphoma suggest that immune suppression may be a contributory mechanism...
  25. ncbi Second malignant neoplasms after cancer in childhood and adolescence: a population-based case-control study in the 5 Nordic countries. The Nordic Society for Pediatric Hematology and Oncology. The Association of the Nordic Cancer Registries
    S Garwicz
    Department of Pediatrics, University Hospital, Lund, Sweden
    Int J Cancer 88:672-8. 2000
    ..Chemotherapy appeared to play only an accessory role during the study period, potentiating the carcinogenic effect of radiotherapy...
  26. ncbi Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms
    D Malkin
    Division of Molecular Genetics, Massachusetts General Hospital Cancer Center, Boston
    N Engl J Med 326:1309-15. 1992
    ..We investigated the possibility that p53 mutations in the germline are associated with second primary cancers that arise in children and young adults who would not be considered as belonging to Li-Fraumeni families...
  27. ncbi Estrogen receptor status of primary breast cancer is predictive of estrogen receptor status of contralateral breast cancer
    Sandra M Swain
    National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 96:516-23. 2004
    ....
  28. ncbi Second cancers after adjuvant tamoxifen therapy for breast cancer in Japan
    Y Matsuyama
    Biostatistics Epidemiology and Preventive Health Sciences, School of Health Sciences and Nursing, University of Tokyo
    Ann Oncol 11:1537-43. 2000
    ..We conducted a retrospective cohort study to evaluate the risk of second primary cancers after adjuvant tamoxifen therapy for breast cancer in Japan...
  29. ncbi Second primary cancers in men with prostate cancer: an increased risk of male breast cancer
    Camilla Thellenberg
    Department of Radiation Sciences, Oncology, Umea University, Sweden
    J Urol 169:1345-8. 2003
    ..However, risk of bladder cancer and kidney cancer increases. We examine the risk of common and rare second primary cancers following prostate cancer in a large population based cohort to identify possible common etiological factors...
  30. ncbi Second malignancies among survivors of germ-cell testicular cancer: a pooled analysis between 13 cancer registries
    Lorenzo Richiardi
    Unit of Cancer Epidemiology, CeRMS and Center for Oncology Prevention, University of Turin, Italy
    Int J Cancer 120:623-31. 2007
    ..0% (95% CI: 4.2-6.0%) vs. 3.1% expected. In conclusion, survivors of testicular cancers have an increased risk of several second primaries, where the effect of the treatment seems to play a major role...
  31. ncbi Is there an increased rate of additional malignancies in patients with mantle cell lymphoma?
    I Barista
    Department of Lymphoma and Myeloma, University of Texas M D Anderson Cancer Center, Houston 77030 4009, USA
    Ann Oncol 13:318-22. 2002
    ..To examine the frequency of additional neoplasms preceding and following the diagnosis of mantle cell lymphoma (MCL)...
  32. ncbi Factors influencing mortality among young women with second primary breast carcinoma
    Jonine L Bernstein
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer 95:2051-8. 2002
    ....
  33. ncbi Concordance of allelic imbalance profiles in synchronous and metachronous bilateral breast carcinomas
    Evgeny N Imyanitov
    N N Petrov Institute of Oncology, St Petersburg, Russia
    Int J Cancer 100:557-64. 2002
    ..014). Overall, our data suggest that sharing natural histories of the disease, which is more evident in synchronous and/or premenopausal forms of biBC, may result in a similarity of molecular portraits in bilateral breast tumors...
  34. ncbi Clonal analysis of bilateral mammary carcinomas by clinical evaluation and partial allelotyping
    Gary M Tse
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    Am J Clin Pathol 120:168-74. 2003
    ..No discrepant results were noted. Stringent application of clinical criteria is accurate for differentiating second primary tumors from metastases...
  35. ncbi Second cancers among 40,576 testicular cancer patients: focus on long-term survivors
    Lois B Travis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Natl Cancer Inst 97:1354-65. 2005
    ..Although second primary cancers are a leading cause of death among men with testicular cancer, few studies have quantified risks among long-term survivors...
  36. pmc Increased risk of second malignancies after in situ breast carcinoma in a population-based registry
    I Soerjomataram
    Department of Public Health, Erasmus MC, PO Box 2040, Rotterdam 3000 CA, The Netherlands
    Br J Cancer 95:393-7. 2006
    ..3, 95% CI: 1.8-2.8) resembled that after invasive breast cancer (SIR: 2.2, 95% CI: 2.1-2.4). Surveillance should be directed towards second (ipsi- and contra-lateral) breast cancer...
  37. ncbi A population-based analysis of risk factors for a second primary cutaneous melanoma among melanoma survivors
    William B Goggins
    Department of Mathematics, Hong Kong Baptist University, Hong Kong
    Cancer 97:639-43. 2003
    ..In this study, the authors examined how the risk of a second primary tumor varied with time from diagnosis of CM and examined the patient-specific factors that modify a CM patient's risk of developing a second primary tumor...
  38. ncbi Long-term sequelae after cancer therapy--survivorship after treatment for testicular cancer
    Sophie D Fossa
    Norwegian Radium Hospital, Department of Clinical Cancer Research, Montebello, Oslo, Norway
    Acta Oncol 43:134-41. 2004
    ..Knowledge of post-treatment long-term morbidity is essential for early recognition and treatment of late complications, and enables adequate counselling of new cancer patients...
  39. ncbi Prognostic impact of the early detection of metachronous contralateral breast cancer
    Stefano Ciatto
    Centro per lo Studio e la Prevenzione Oncologica, Viale A Volta 171, 50131 Florence, Italy
    Eur J Cancer 40:1496-501. 2004
    ..Although length bias may have occurred (symptomatic MCBC had a shorter free interval from the first cancer), the present evidence supports the practice of active follow-up aimed at the early detection of asymptomatic MCBC...
  40. ncbi Bilateral testicular germ cell tumors: twenty-year experience at M. D. Anderson Cancer Center
    Mingxin Che
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer 95:1228-33. 2002
    ..D. Anderson Cancer Center over a 20-year period with emphasis on their incidence, histologic features, and clinical features...
  41. ncbi Bilateral testicular germ-cell tumors--a single centre long-term experience
    D Ondrus
    Department of Urology, Comenius University Medical School, , Bratislava, Slovakia
    Int Urol Nephrol 33:521-4. 2001
    ..CONCLUSIONS: All patients with unilateral GCTT have an increased risk of developing a contralateral testicular tumor, even decades after diagnosis. Management should be individualised for each patient...
  42. ncbi Effect of breast cancer radiotherapy and cigarette smoking on risk of second primary lung cancer
    Elizabeth L Kaufman
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Clin Oncol 26:392-8. 2008
    ..Prior studies have found that postmastectomy radiotherapy (PMRT) for breast cancer (BC) increases the risk of lung cancer (LC). We explored the joint effects of cigarette smoking and PMRT on LC risk...
  43. ncbi Second primary neoplasms in patients with laryngeal carcinoma
    A C Nikolaou
    University Department of Otorhinolaryngology and Head and Neck Surgery, AHEPA University Hospital, Aristotle University, Thessaloniki, Greece
    Laryngoscope 110:58-64. 2000
    ....
  44. ncbi Extragonadal germ cell tumors: relation to testicular neoplasia and management options
    Carsten Bokemeyer
    Tuebingen University Medical Center II, Tuebingen, Germany
    APMIS 111:49-59; discussion 59-63. 2003
    ..Patients with mediastinal nonseminomas have a five-years survival rate of 45%. This outcome is clearly inferior compared to patients with nonseminomatous retroperitoneal primaries who have a five-year survival rate of 62%...
  45. ncbi Therapy-associated solid tumors
    Lois B Travis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Acta Oncol 41:323-33. 2002
    ..Thus, the benefit derived from many cancer therapies far outweighs any risk of developing a second cancer...
  46. ncbi Tamoxifen and risk of large bowel cancer in women with breast cancer
    P A Newcomb
    Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, WA 98109 1024, USA
    Breast Cancer Res Treat 53:271-7. 1999
    ..The increasingly consistent association between estrogen replacement therapy and colorectal cancer suggests that the anti-estrogen tamoxifen may also be associated with large bowel cancer incidence...
  47. ncbi Second neoplasms after treatment of childhood cancer in Slovenia
    Janez Jazbec
    Department of Pediatrics, Division of Oncology and Hematology, University Medical Centre Ljubljana, Ljubljana, Slovenia
    Pediatr Blood Cancer 42:574-81. 2004
    ..The occurrence of second neoplasms is one of most serious late effects observed in cancer survivors...
  48. ncbi Photodynamic therapy of early squamous cell carcinomas of the esophagus: a review of 31 cases
    J F Savary
    Dept of Otolaryngology, Head and Neck Surgery, CHUV Hospital, Lausanne, Switzerland
    Endoscopy 30:258-65. 1998
    ....
  49. ncbi DNA repair gene polymorphisms and risk of second primary neoplasms and mortality in oral cancer patients
    Thomas J Gal
    Department of Otolaryngology Head and Neck Surgery, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    Laryngoscope 115:2221-31. 2005
    ..that polymorphisms in genes involved in DNA repair pathways are associated with the development of second primary neoplasms of the upper aerodigestive tract (UADT), as well as mortality, in patients previously diagnosed with oral ..
  50. ncbi Post-radiation sarcomas: a review of the clinical and imaging features in 63 cases
    D G Sheppard
    Division of Diagnostic Imaging, Department of Radiology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Radiol 56:22-9. 2001
    ..We set out to retrospectively review the clinical and therapeutic demographics, as well as the cross-sectional imaging findings in patients with post-radiation sarcomas...
  51. ncbi Second primary neoplasms in survivors of Wilms' tumour--a population-based cohort study from the British Childhood Cancer Survivor Study
    Aliki J Taylor
    Centre for Childhood Cancer Survivor Studies, Department of Public Health and Epidemiology, The University of Birmingham, Edgbaston, Birmingham, UK
    Int J Cancer 122:2085-93. 2008
    A British population-based cohort study was carried out to determine the risk of second primary neoplasms in survivors of Wilms' tumour...
  52. ncbi Testicular germ cell cancer despite previous local radiotherapy to the testis
    K P Dieckmann
    Urologische Abteilung, Albertinen Krankenhaus, Suentelstrasse 11a, D 22457, Hamburg, Germany
    Eur Urol 41:643-9; discussion 649-50. 2002
    ..Thus, the general assumption is that the development of invasive germ cell tumours can be prevented by this radiotherapy...
  53. ncbi Is history of squamous-cell skin cancer a marker of poor prognosis in patients with cancer?
    J Askling
    Karolinska Institute, Stockholm, Sweden
    Ann Intern Med 131:655-9. 1999
    ..Nonmelanoma skin cancer is associated with increased occurrence of subsequent cancer and death from cancer, but it is not known whether a history of skin cancer is associated with poor prognosis after a second diagnosis of cancer...
  54. ncbi Second malignant neoplasms among long-term survivors of Hodgkin's disease: a population-based evaluation over 25 years
    Graca M Dores
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South, Suite 7039, Bethesda, MD 20892, USA
    J Clin Oncol 20:3484-94. 2002
    ....
  55. ncbi Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease
    Lois B Travis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    JAMA 290:465-75. 2003
    ..Quantitative associations between radiotherapy dose delivered to the breast and administered chemotherapy have not been reported to date in large series, nor has the influence of ovarian exposures on subsequent risk...
  56. ncbi Second cancers among 104,760 survivors of cervical cancer: evaluation of long-term risk
    Anil K Chaturvedi
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, 6120 Executive Blvd, EPS 7072, Rockville, MD 20852, USA
    J Natl Cancer Inst 99:1634-43. 2007
    ....
  57. ncbi Can we reduce the incidence of second primary malignancies occurring after radiotherapy? A critical review
    Maurice Tubiana
    Institute Gustave Roussy, Villejuif, France
    Radiother Oncol 91:4-15; discussion 1-3. 2009
    ..In parallel, radiation therapy philosophy must evolve, and the aim of treatment should be to deliver the minimal effective radiation therapy rather than the maximal tolerable dose...
  58. pmc Dose to the contralateral breast from radiotherapy and risk of second primary breast cancer in the WECARE study
    Marilyn Stovall
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 72:1021-30. 2008
    ..To quantify the risk of second primary breast cancer in the contralateral breast (CB) after radiotherapy (RT) for first breast cancer...
  59. ncbi Risk of second malignancies after adjuvant radiotherapy for breast cancer: a large-scale, single-institution review
    Youlia M Kirova
    Department of Radiation Oncology, Institut Curie, Paris, France
    Int J Radiat Oncol Biol Phys 68:359-63. 2007
    ..The aim of this study was to estimate the risk of second malignancies (SM) after radiation therapy (RT) for breast cancer (BC) in a large, institutional, homogeneous cohort of patients...
  60. ncbi Risks of second primary breast and urogenital cancer following female breast cancer in the south of The Netherlands, 1972-2001
    I Soerjomataram
    Netherlands Institute of Health Sciences, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Eur J Cancer 41:2331-7. 2005
    ..However, breast cancer has an inverse relationship to risk of cervical cancer. Changes in behavioural risk factors are important for lowering the risk of second cancer after breast cancer...
  61. ncbi Tamoxifen and risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study. Hereditary Breast Cancer Clinical Study Group
    S A Narod
    Centre for Research on Women s Health, Women s College Hospital, University of Toronto, Ontario, Canada
    Lancet 356:1876-81. 2000
    ..Tamoxifen protects against contralateral breast cancer in the general population, but whether it protects against contralateral breast cancer in BRCA1 or BRCA2 mutation carriers is not known...
  62. pmc Morphological types of breast cancer in family members and multiple primary tumours: is morphology genetically determined?
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
    Breast Cancer Res 4:R7. 2002
    ..We conducted the present study to determine whether breast cancer morphology is genetically determined...
  63. ncbi The epidemiology of second primary cancers
    Lois B Travis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Executive Plaza South, Suite 7086, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 15:2020-6. 2006
    ....
  64. ncbi PMS2 mutations in childhood cancer
    Michel De Vos
    University of Leeds, Yorkshire Regional Genetics Service, United Kingdom
    J Natl Cancer Inst 98:358-61. 2006
    ..This cancer syndrome can be mistaken for neurofibromatosis type 1, with important management implications including the risk of the disorder occurring in siblings and the likelihood of tumor development in affected individuals...
  65. ncbi Solid tumors after chronic lymphocytic leukemia
    M Hisada
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
    Blood 98:1979-81. 2001
    ..91) and for cancers of the stomach (O/E = 1.76) and bladder (O/E = 1.52) among women. Additional investigations of cancers after CLL are needed to explore the role of immunologic impairment and/or other etiologic influences...
  66. ncbi Long-term risk of second malignancy in survivors of Hodgkin's disease treated during adolescence or young adulthood
    F E van Leeuwen
    Departments of Epidemiology, Medical Oncology, Radiotherapy, and Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Clin Oncol 18:487-97. 2000
    ..To quantify the long-term risk of second primary cancers (SCs) in patients diagnosed with Hodgkin's disease (HD) during adolescence or young adulthood...
  67. pmc Radiation-induced malignancies following radiotherapy for breast cancer
    R Roychoudhuri
    Thames Cancer Registry, Division of Cancer Studies, Guy s, King s and St Thomas School of Medicine, 1st Floor, Capital House, 42 Weston Street, London SE1 3QD, UK
    Br J Cancer 91:868-72. 2004
    ..99, 95% CI 1.13-9.33), for second breast cancer at 5-10 years (RR 1.34, 95% CI 1.10-1.63) and 15+ years (RR 1.26, 95% CI 1.00-1.59) and oesophageal cancer at 15+ years (RR 2.19, 95% CI 1.10-4.62)...
  68. ncbi Long-term solid cancer risk among 5-year survivors of Hodgkin's lymphoma
    David C Hodgson
    Princess Margaret Hospital, University Health Network, and the Department of Radiation Oncology, University of Toronto, Canada
    J Clin Oncol 25:1489-97. 2007
    ..However, no investigation has used multivariate modeling to estimate the relative risk (RR), excess absolute risk (EAR), and cumulative incidence for specific attained ages and ages at HL diagnosis...
  69. ncbi Lung carcinoma after radiation therapy in women treated with lumpectomy or mastectomy for primary breast carcinoma
    Lydia B Zablotska
    Department of Epidemiology, Mailman School of Public Health, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cancer 97:1404-11. 2003
    ....
  70. ncbi Risk of a new primary cancer among patients with lung cancer of different histological types
    L Teppo
    Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Liisankatu 21 B, FIN 00170, Helsinki, Finland
    Eur J Cancer 37:613-9. 2001
    ....
  71. ncbi Cumulative incidence of secondary neoplasms as a first event after childhood acute lymphoblastic leukemia
    Nobuko Hijiya
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    JAMA 297:1207-15. 2007
    ..Little is known about the incidence of secondary neoplasms after 15 to 20 years in children and adolescents who were treated for acute lymphoblastic leukemia...
  72. ncbi Individualized estimates of second cancer risks after contemporary radiation therapy for Hodgkin lymphoma
    David C Hodgson
    University of Toronto, Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada
    Cancer 110:2576-86. 2007
    ..This study gives individualized estimates for the risks of lung and female breast cancer expected with contemporary involved-field RT and low-dose (20 Gy) RT for mediastinal Hodgkin lymphoma...
  73. ncbi Screening mammography for young women treated with supradiaphragmatic radiation for Hodgkin's lymphoma
    L Lee
    Division of Medical Oncology and Hematology, Massachusetts General Hospital Cancer Center, USA
    Ann Oncol 19:62-7. 2008
    ..Female survivors of Hodgkin's lymphoma (HL) treated with supradiaphragmatic radiation therapy (SRT) are at increased risk of breast cancer (BC), but there is little data on the optimal screening strategy...
  74. ncbi Lung cancer risks in women with previous breast cancer
    M Prochazka
    Department of Medical Epidemiology, Karolinska Institutet, PO Box 281, S 171 77, Stockholm, Sweden
    Eur J Cancer 38:1520-5. 2002
    ..Women with breast cancer have a significantly increased risk of developing a subsequent lung cancer possibly related to an interaction between radiotherapy and smoking...
  75. pmc Second malignancy in patients with Hodgkin's disease treated at the Royal Marsden Hospital
    A J Swerdlow
    Epidemiological Monitoring Unit, Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine, UK
    Br J Cancer 75:116-23. 1997
    ..The risks of solid malignancies need clarification by larger collaborative epidemiological studies...
  76. ncbi Granulocyte colony-stimulating factor and the risk of secondary myeloid malignancy after etoposide treatment
    Mary V Relling
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 101:3862-7. 2003
    ..Even when children receiving irradiation were excluded, the incidence was still higher in those receiving G-CSF (P =.019). In the setting of intensive antileukemic therapy, short-term use of G-CSF may increase the risk of t-ML...
  77. ncbi Risk of subsequent cancer following invasive or in situ squamous cell skin cancer
    Jimmy Thomas Efird
    Division of Epidemiology, Department of Health Research and Policy, Stanford School of Medicine, Stanford, CA 94305 5405, USA
    Ann Epidemiol 12:469-75. 2002
    ..Determine the risk of subsequent cancer following squamous cell skin cancer...
  78. ncbi Long-term risk of second malignancy after treatment of Hodgkin's disease: the influence of treatment, age and follow-up time
    A Foss Abrahamsen
    Department of Medical Oncology and Radiotherapy, The Norwegian Radium Hospital, Oslo, Norway
    Ann Oncol 13:1786-91. 2002
    ..The median age at diagnosis of HD was 40 years, and the median time at follow-up was 14 years...
  79. ncbi Second primary malignancy risk in thyroid cancer survivors: a systematic review and meta-analysis
    Shoba Subramanian
    Endocrinology, Stanford University, Palo Alto, California, USA
    Thyroid 17:1277-88. 2007
    ..To determine the risk of second primary malignancies (SPMs) in thyroid cancer survivors...
  80. ncbi Reproductive history and risk of second primary breast cancer: the WECARE study
    Joan A Largent
    Epidemiology Division, Department of Medicine, University of California, Irvine, Irvine, CA 92697 7555, USA
    Cancer Epidemiol Biomarkers Prev 16:906-11. 2007
    ..Women with an initial breast cancer diagnosis are at elevated risk of developing subsequent cancer in the contralateral breast. Studies of reproductive factors and contralateral breast cancer (CBC) have provided inconsistent results...
  81. ncbi [Renal cancer and second cancer: critical review of the literature]
    Yann Neuzillet
    Service Urologie, Hopital Salvator, Marseille, France
    Prog Urol 17:35-40. 2007
    ..The pathophysiology of these associations has not been clearly elucidated, but probably involves common genetic alterations. These epidemiological associations should be taken into account in the follow-up of patients with RCC...
  82. ncbi Occurrence of both bladder and prostate cancer in five cancer registries in Belgium, The Netherlands and the United Kingdom
    Eliane Kellen
    Department of General Practice, Katholieke Universiteit Leuven Comprehensive Cancer Institute Limburg, Belgium
    Eur J Cancer 43:1694-700. 2007
    ..To assess the occurrence of both bladder and prostate tumours in five well defined cancer registries...
  83. ncbi The incidence of lung carcinoma after surgery for breast carcinoma with and without postoperative radiotherapy. Results of National Surgical Adjuvant Breast and Bowel Project (NSABP) clinical trials B-04 and B-06
    Melvin Deutsch
    Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Cancer 98:1362-8. 2003
    ....
  84. pmc Risk of subsequent invasive breast carcinoma after in situ breast carcinoma in a population covered by national mammographic screening
    R Rawal
    German Cancer Research Center, Division of Molecular Genetic Epidemiology, Im Neuenheimer Feld 580, Heidelberg D 69120, Germany
    Br J Cancer 92:162-6. 2005
    ..In situ and the subsequent invasive breast cancers did not seem to share their morphologies...
  85. ncbi A high-grade primary leiomyosarcoma of the bladder in a survivor of retinoblastoma
    S X Liang
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Arch Pathol Lab Med 125:1231-4. 2001
    ..We also investigated the potential molecular pathogenesis of the leiomyosarcoma...
  86. ncbi Incidence of second primary breast cancer among women with a first primary in Manitoba, Canada
    Y Chen
    Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ontario, Canada
    Breast Cancer Res Treat 67:35-40. 2001
    ..The data provide epidemiological information on second primary breast cancer risk for the general female population in Manitoba, Canada...
  87. ncbi Effect of systemic adjuvant treatment on risk for contralateral breast cancer in the Women's Environment, Cancer and Radiation Epidemiology Study
    Lisbeth Bertelsen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    J Natl Cancer Inst 100:32-40. 2008
    ..However, less is known about how long the risk is reduced and the impact of factors such as age and menopausal status...
  88. ncbi Mammographic screening in women at increased risk of breast cancer after treatment of Hodgkin's disease
    Ava Kwong
    Department of Radiology, Standford Unviersity School of Medicine, Stanford, California, USA
    Breast J 14:39-48. 2008
    ..However, early mammographic screening facilitated diagnosis of in situ and early invasive cancer in 3.5% of our subjects...
  89. ncbi Second primary cancers following breast cancer in the Japanese female population
    H Tanaka
    Department of Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537 8511, Japan
    Jpn J Cancer Res 92:1-8. 2001
    ..Medical surveillance of breast cancer patients for NHL, as well as for ovarian cancer and thyroid cancer, is required...
  90. ncbi Risk of second primary cancer among patients with early operable breast cancer registered or randomised in Danish Breast Cancer cooperative Group (DBCG) protocols of the 77, 82 and 89 programmes during 1977-2001
    Michael Andersson
    Department of Oncology, Finsen Centre, Rigshospitalet University Hospital, Copenhagen, Denmark
    Acta Oncol 47:755-64. 2008
    ..Ovary cancer risk was inversely related to age at diagnosis but not to treatment and corpus uteri cancer risk related to tamoxifen treatment, relative risk 1.57. The findings are in accordance to other population based studies...
  91. ncbi Second primary cancers in patients with stage III non-small cell lung cancer successfully treated with chemo-radiotherapy
    Tomoya Kawaguchi
    National Hospital Study Group for Lung Cancer in Japan
    Jpn J Clin Oncol 36:7-11. 2006
    ..The purpose of the current study is to assess the incidence of SPC and the impact of smoking status on the SPC in long-term survivors with stage III NSCLC after chemo-radiotherapy...
  92. pmc Second primary cancers among 109 000 cases of non-Hodgkin's lymphoma
    P Brennan
    International Agency for Research on Cancer, 69008 Lyon, France
    Br J Cancer 93:159-66. 2005
    ..Bidirectional effects for several cancer sites of potential viral origin argue strongly for a role for immune suppression in NHL...
  93. ncbi Lifetime risks of common cancers among retinoblastoma survivors
    Olivia Fletcher
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    J Natl Cancer Inst 96:357-63. 2004
    ..However, their risks for the epithelial cancers that commonly occur after age 50 years are not known...
  94. pmc Multifocal squamous cell carcinoma of the oesophagus following radiotherapy for bilateral breast carcinoma
    S Shousha
    Department of Histopathology, Imperial College School of Medicine and Charing Cross Hospital, London W6 8RF, UK
    J Clin Pathol 54:718-20. 2001
    ..The strong family history of malignant diseases raises the possibility that, in addition, genetic factors might have played a role in the development of the oesophageal disease...
  95. ncbi Risk of subsequent solid tumors after non-Hodgkin's lymphoma: effect of diagnostic age and time since diagnosis
    Kari Hemminki
    Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Im Neuenheimer Feld 580, Heidelberg, Germany
    J Clin Oncol 26:1850-7. 2008
    ..Quantitative data on solid tumors are limited. We focus on survivors of non-Hodgkin's lymphoma (NHL) because the disease is diagnosed at a wide range of ages and treated uniformly primarily with chemotherapy...
  96. ncbi Mortality after cure of testicular seminoma
    Gunar K Zagars
    Department of Radiation Oncology, Box 97, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 22:640-7. 2004
    ..To determine the incidence of potentially treatment-related mortality in long-term survivors of testicular seminoma treated by orchiectomy and radiation therapy (XRT)...
  97. pmc Increased mortality rates in young and middle-aged patients with malignant germ cell tumours
    S D Fossa
    The Norwegian Radium Hospital, Department of Clinical Research, Montebello, N 0310 Oslo, Norway
    Br J Cancer 90:607-12. 2004
    ..The increased death risk due to benign gastrointestinal disorders, probably related to radiotherapy, requires future in-depth analysis...
  98. ncbi Second primary cancers after enrollment in the COMS trials for treatment of choroidal melanoma: COMS Report No. 25
    Marie Diener-West
    COMS Coordinating Center, Wilmer Clinical Trials and Biometry, 550 N Broadway, Ninth Floor, Baltimore, MD 21205, USA
    Arch Ophthalmol 123:601-4. 2005
    ..To report sites of second primary cancer and the time to first diagnosis during routine follow-up after treatment for choroidal melanoma...
  99. ncbi Ipsilateral breast tumour recurrence in hereditary breast cancer following breast-conserving therapy
    C Seynaeve
    Family Cancer Clinic, Department of Medical Oncology, Erasmus University Medical Centre Daniel den Hoed Cancer Centre, Groene Hilledijk, 301, 3075 EA Rotterdam, The Netherlands
    Eur J Cancer 40:1150-8. 2004
    ..These data suggest an indication for long-term follow up in HBC and should be taken into account when additional 'risk-reducing' surgery after primary BCT is eventually considered...
  100. ncbi Incidence of multiple primary malignancies in a cohort of adult patients with soft tissue sarcoma
    Ukihide Tateishi
    Division of Diagnostic Radiology, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, 104 0045 Tokyo, Japan
    Jpn J Clin Oncol 35:444-52. 2005
    ..The current study was performed to quantify the risk of development of multiple primary malignancies in adult patients with soft tissue sarcoma...
  101. pmc Breast cancer risk following radiotherapy for Hodgkin lymphoma: modification by other risk factors
    Deirdre A Hill
    Division of Cancer Epidemiology and Genetics and Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Blood 106:3358-65. 2005
    ..The additional increased relative risk of breast cancer after RT for HL is unlikely to be larger among women with a family history of breast or ovarian cancer than among other women...

Research Grants64

  1. LONG TERM OUTCOMES FOR WOMEN WITH BREAST CA IN SITU
    Elizabeth Claus; Fiscal Year: 2004
    ..The data are unique in that epidemiologic, biologic and clinical variables will have been collected allowing us to study the relationship of these variables with long term outcome. ..
  2. Integrating Tobacco Treatment into Cancer Care
    Elyse R Park; Fiscal Year: 2013
    ..Furthermore, it will provide information to lay the groundwork for dissemination efforts into a variety of cancer care settings. ..
  3. The influence of the built environment on outcomes after breast cancer
    Theresa H M Keegan; Fiscal Year: 2010
    ....
  4. Smoking Relapse-Prevention Intervention for Cancer Patients
    VANI N SIMMONS; Fiscal Year: 2013
    ..Efforts aimed at maintaining tobacco abstinence among this population could have significant public health implications, including improved physical functioning, quality of life, and survival for cancer patients. ..
  5. Physical Activity and Survival in Cancer Patients
    I Min Lee; Fiscal Year: 2010
    ..It will help clarify whether physical activity, an inexpensive, modifiable behavior with little adverse effect, can prolong survival in cancer patients. ..
  6. Ultrasound-based tumor targeting and thermal ablation monitoring system
    Elisa E Konofagou; Fiscal Year: 2013
    ..More importantly, it may prove to be an important option to women without limited, focal disease, for whom less invasive and more focal treatment is most beneficial with minimized mortality and risk. ..
  7. B7-H1 Signaling in Ovarian Cancer
    Tyler J Curiel; Fiscal Year: 2013
    ..Our insights into tumor-associated immune dysfunction promise to help improve the efficacy of cancer immunotherapy, whose record of success to date has been only modest. ..
  8. DEVELOPMENT OF SOFTWARE SYSTEMS TO FACILITATE THE USE OF ELECTRONIC DATA RECORDS
    SUZANNE MARCH; Fiscal Year: 2009
    ..Post Phase II, other lexicons will be added to process other cancer sites found through MRI/CT/PET/F-MRI techniques. ..
  9. EXCRETED ALKYL PURINES AS MARKERS OF IN VIVO DNA DAMAGE
    David Shuker; Fiscal Year: 1990
    ..This would enable key ideas in molecular epidemiology to be validated and also offer the specific benefit of identifying modifications in therapy required to reduce the risk of second cancers...
  10. INCREASING F & V INTAKE IN HEAD & NECK CANCER PATIENTS
    Brenda Cartmel; Fiscal Year: 2000
    ..If feasible this intervention could be incorporated into usual care for these patients to reduce their risk of subsequent cancer. ..
  11. MAMMOGRAPHIC DENSITY AND BREAST CANCER AFTER DCIS
    Laurel Habel; Fiscal Year: 2000
    ..abstract_text> ..
  12. PPAR GAMMA AGONISTS FOR THE PREVENTION OF COLON CANCER
    Michael Wargovich; Fiscal Year: 2002
    ..Secondary studies will assess the effects of these compounds on colonic cell proliferation and apoptotic rates. These studies will define PPAR gamma as a possible target for chemopreventive drug development. ..
  13. Prediction of Second Cancer Risks for Children Treated with Proton - vs. - Photon
    Wayne D Newhauser; Fiscal Year: 2010
    ..In the future, we expect that the lower-risk treatments will result in fewer second cancers and this will translate into longer, higher-quality lives for survivors of childhood cancer (presently 270,000 persons in the United States). ..
  14. BREAST CANCER PREVENTION IN HODGKINS DISEASE
    Judy Garber; Fiscal Year: 2002
    ..We will also evaluate mammographic density as a potential intermediate endpoint that might permit more rapid completion of a randomized study. ..
  15. MOLECULAR PROBES OF LARYNGEAL SQUAMOUS CELL CARCINOMA
    Steven Scholnick; Fiscal Year: 2003
    ....
  16. TAMOXIFEN THERAPY AND RISK OF REPRODUCTIVE CANCERS
    Linda Cook; Fiscal Year: 1993
    ....
  17. BALANCING SURVIVAL AND OTOTOXICITY IN CISPLATIN THERAPY
    Yuelin Li; Fiscal Year: 2003
    ....
  18. Multicentric Pooled Analysis of Second Primary Cancer
    Paul Brennan; Fiscal Year: 2004
    ..In order to conduct a systematic analysis of second primary neoplasms for all cancer sites, we have developed an international multi-center study of second primary cancers ..
  19. CLUE STUDIES--EVALUATING BIOMARKERS OF CARCINOGENESIS
    Kathy Helzlsouer; Fiscal Year: 2004
    ..abstract_text> ..
  20. SECOND CANCER FOLLOWING TREATMENT FOR
    E Holowaty; Fiscal Year: 1992
    ....
  21. Protein Biomarkers of Cancer Risk in Older Persons
    Christopher Li; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  22. c-erbB-2 and Risk of Contralateral Breast Cancer
    Christopher Li; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  23. Depo-Provera and Breast Cancer: Epidemiology/Pathology
    Christopher Li; Fiscal Year: 2009
    ..such as parity and body mass index, modify this association?;and (3) Does the association between DMPA and breast cancer risk vary by histologic type or by the expression of steroid receptors including ERq, ERft, and PR? ..
  24. HEPATITIS C IN CHILDHOOD CANCER SURVIVORS
    Melissa Hudson; Fiscal Year: 2003
    ..abstract_text> ..
  25. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2009
    ..abstract_text> ..
  26. BONE MARROW TRANSPLANT (BMT) SURVIVORS STUDY
    Smita Bhatia; Fiscal Year: 2003
    ..g., second cancers, births, cardiac complications, etc.) that may have occurred since the completion of the initial questionnaire. ..
  27. Novel, Noninvasive Biomarker of Fruit & Vegetable Intake
    Susan Mayne; Fiscal Year: 2005
    ..abstract_text> ..
  28. Epidemiologic Parameters of Rare Cancer Risk Factors
    Colin Begg; Fiscal Year: 2005
    ..All of these aims are motivated by an international study of the genetic epidemiology of melanoma that is currently in progress. ..
  29. Yale/NCI Cooperative Training Program in Cancer Epidemiology
    Susan Mayne; Fiscal Year: 2007
    ..We anticipate that graduates of this program will be uniquely qualified to be future leaders in the field of cancer epidemiology and genetics. [unreadable] [unreadable] [unreadable] [unreadable]..
  30. HIGH ENERGY IONS AND GENOMIC INSTABILITY
    Eric Hall; Fiscal Year: 2001
    ....
  31. Minicomputer Upgrade for the Clinical Resarch Database
    Colin Begg; Fiscal Year: 2002
    ..This proposal is a request for funds to upgrade the hardware platform once again to maintain the performance of the system in the face of these rapidly increasing demands. ..
  32. A Method for Validating Gene - Disease Associations
    Colin Begg; Fiscal Year: 2004
    ..abstract_text> ..
  33. Statistical Methods for Identifying Clonal Tumors
    Colin B Begg; Fiscal Year: 2011
    ....
  34. Obesity and Outcomes After Early Stage Breast Cancer
    James Dignam; Fiscal Year: 2003
    ..These investigations will provide valuable information for current patient management and insights into appropriate prospective interventions to improve breast cancer survivorship. ..
  35. Patient Oriented Outcomes of Prophylactic Mastectomy
    Ann Geiger; Fiscal Year: 2003
    ..This study will provide critical information for women and their health care providers considering prophylactic mastectomy, a decision currently based on a dearth of information on long-term patient-oriented outcomes. ..
  36. Transfer of the CD40 ligand gene to esophageal carcinoma
    Robert Korst; Fiscal Year: 2007
    ..This study will help determine if intratumoral administration of the AdCUCD40L vector is safe, and evokes sufficient DC-related host responses to warrant further studies in esophageal cancer. ..
  37. IMRT in the Treatment of Node-Positive Breast Cancer
    Lori Pierce; Fiscal Year: 2006
    ..3) Study 60 patients treated with either the best delivery-optimized motion corrected plan from Aim 2 or PWTF and compare plans using heart and lung metrics. ..
  38. IMRT in the Treatment of Node-Positive Breast Cancer
    Lori Pierce; Fiscal Year: 2003
    ..4) Determine the effect of motion on static IMRT and PWTF dose distributions, and then correct/adjust for motion to determine the best delivery-optimized plan. ..
  39. Is Stroke a Late Effect of Chemotherapy?
    Ann Geiger; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  40. Mentored Patient-Oriented Research Career Development Aw
    David Rizzieri; Fiscal Year: 2004
    ..These results will lead to future improvements in maximizing the anti-tumor effects of allogeneic therapy, hastening immunologic recovery, and minimizing the toxicity of this procedure. ..
  41. Correlative Studies of erbB-2/HER2 and p53 in CALGB Pro.
    Daniel Hayes; Fiscal Year: 2005
    ....
  42. Angiogenic balance in a human tumor model of dormancy
    Taturo Udagawa; Fiscal Year: 2005
    ..An understanding of the interplay between angiogenic and antiangiogenic activities will yield insight into the biological basis for human tumor dormancy, and may also uncover new molecules for the treatment of cancer. ..
  43. Biobehavioral Effects of Yoga During Cancer Treatment
    Lorenzo Cohen; Fiscal Year: 2007
    ..abstract_text> ..
  44. OCULAR MELANOMA
    David Wilson; Fiscal Year: 2003
    ..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
  45. COMPUTER AIDED STRESS REDUCTION, MENTAL HEALTH & CANCER
    Lorenzo Cohen; Fiscal Year: 2002
    ....
  46. CYTOGENETIC MODELS FOR ASSESSING LOW DOSE RADIATION RISK
    Rainer Sachs; Fiscal Year: 2001
    ..By studying molecular, mechanisms relevant to low doses and low dose-rates quantitatively the project will help firm-up risk estimates and make them more credible. ..
  47. CHILDRENS CANCER GROUP
    Stephen Feig; Fiscal Year: 2002
    ..The melding of a mature, active and diverse clinical research program with a productive thrust in translational and outcomes research will be an asset to CCG in the coming years. ..
  48. Lung Cancer Chemoradiation: Predictors of Survival
    Xifeng Wu; Fiscal Year: 2009
    ..This multivariate prognostic study could have long-term prognostic potential by allowing greater individualization of therapy, based on the genetic makeup of the patient, thereby both increasing efficacy and reducing morbidity. ..
  49. CHILDRENS CANCER GROUP
    Joseph Neglia; Fiscal Year: 2002
    ..This funding will assure the continued leadership of Minnesota investigators in all aspects of the Children's Cancer Group over the coming five years. ..
  50. A Pilot Writing Program for Multiethnic Breast Cancer Pt
    Carolyn Gotay; Fiscal Year: 2004
    ..This study will provide an initial step toward achieving this goal. ..
  51. GENETIC ANALYSIS OF HEREDITARY PROSTATE CANCER FAMILIES
    Kathleen Cooney; Fiscal Year: 2009
    ..Ultimately, this information may have clinical utility to identify those men at highest risk of prostate cancer who may benefit from early detection and/or chemoprevention strategies. ..
  52. NATIONAL WILMS TUMOR STUDY -5
    Daniel Green; Fiscal Year: 2003
    ..The survival of most children treated for WT allows the study of genetic and treatment factors associated with the etiology of the disease and/or the occurrence of complications of therapy. ..
  53. Isolation of Genes for Radiation Sensitivity
    Patrick Concannon; Fiscal Year: 2010
    ....
  54. Biobehavioral Effects of Emotional Expression in Cancer
    Lorenzo Cohen; Fiscal Year: 2006
    ..The effects of the intervention should be evident throughout recovery and across indices of quality of life, mental health, subjective symptoms of stress, and immune function. ..
  55. GENETIC INFLUENCE ON MUTAGEN SENSITIVITY--A TWIN STUDY
    Xifeng Wu; Fiscal Year: 2004
    ..Additionally, these potential biomarkers may ultimately be used to identify individuals who should be targeted for more intense screening programs or behavior modification interventions. ..
  56. PREDICTORS OF RELAPSE TO SMOKING IN LUNG CANCER
    Mario Schootman; Fiscal Year: 2005
    ..abstract_text> ..
  57. CLINICAL AND BIOLOGICAL BASIS OF 18F-FDG PET IN CANCER
    Yuman Fong; Fiscal Year: 2001
    ..abstract_text> ..
  58. Identification and Preclinical Evaluation of New Brain Tumor Therapies
    David Gutmann; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  59. Markers of Genetic Susceptibility to Bladder Cancer
    Xifeng Wu; Fiscal Year: 2008
    ..The ability to rapidly screen individuals for risk, using minimally invasive procedures (blood samples), has immense clinical implication, such as intensive screening and chemopreventive interventions. ..
  60. Health Outcomes for Hodgkin Disease Survivors
    Debra Friedman; Fiscal Year: 2007
    ..abstract_text> ..
  61. Liver Regeneration in Man--Effects or Adjuvant Therapy
    Yuman Fong; Fiscal Year: 2005
    ....
  62. Fiber and Colorectal Adenomas: A Pooling Project
    Elizabeth Jacobs; Fiscal Year: 2005
    ..If it is found that certain groups may receive greater benefit from fiber, then public health recommendations can be made which target these groups and prevent the recurrence of colorectal adenomas. ..