radiation induced neoplasms

Summary

Summary: Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.

Top Publications

  1. ncbi Radiation-induced second cancers: the impact of 3D-CRT and IMRT
    Eric J Hall
    Center for Radiological Research, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 56:83-8. 2003
  2. ncbi Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950-1997
    Dale L Preston
    Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan
    Radiat Res 160:381-407. 2003
  3. pmc Radiation and breast cancer: a review of current evidence
    Cécile M Ronckers
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, NIH, HHS, Bethesda, Maryland, USA
    Breast Cancer Res 7:21-32. 2005
  4. ncbi Radiation carcinogenesis
    J B Little
    Department of Cancer Cell Biology, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Carcinogenesis 21:397-404. 2000
  5. ncbi The 15-Country Collaborative Study of Cancer Risk among Radiation Workers in the Nuclear Industry: estimates of radiation-related cancer risks
    E Cardis
    International Agency for Research on Cancer, Lyon, France
    Radiat Res 167:396-416. 2007
  6. ncbi Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA-dependent protein kinase catalytic subunit) gene
    Y Yu
    Department of Radiation Oncology, The University of Texas Medical Branch, Galveston 77555, USA
    Cancer Res 61:1820-4. 2001
  7. ncbi Radiation effects on breast cancer risk: a pooled analysis of eight cohorts
    Dale L Preston
    Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan
    Radiat Res 158:220-35. 2002
  8. ncbi Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): a nested case-control study
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7238, USA
    Lancet 365:2014-23. 2005
  9. ncbi Cancer risks from medical radiation
    Elaine Ron
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 7048, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Health Phys 85:47-59. 2003
  10. ncbi Effect of recent changes in atomic bomb survivor dosimetry on cancer mortality risk estimates
    Dale L Preston
    Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan
    Radiat Res 162:377-89. 2004

Detail Information

Publications238 found, 100 shown here

  1. ncbi Radiation-induced second cancers: the impact of 3D-CRT and IMRT
    Eric J Hall
    Center for Radiological Research, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 56:83-8. 2003
    ..75% for patients surviving 10 years. The numbers may be larger for longer survival (or for younger patients), but the ratio should remain the same...
  2. ncbi Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950-1997
    Dale L Preston
    Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan
    Radiat Res 160:381-407. 2003
    ..Lifetime risk summaries are used to examine uncertainties of the LSS noncancer disease findings...
  3. pmc Radiation and breast cancer: a review of current evidence
    Cécile M Ronckers
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, NIH, HHS, Bethesda, Maryland, USA
    Breast Cancer Res 7:21-32. 2005
    ....
  4. ncbi Radiation carcinogenesis
    J B Little
    Department of Cancer Cell Biology, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Carcinogenesis 21:397-404. 2000
    ..This 'bystander effect' involves gap junction mediated cell-cell communication, and activation of the p53 damage response pathway. The possible role of these phenomena in radiation carcinogenesis is discussed...
  5. ncbi The 15-Country Collaborative Study of Cancer Risk among Radiation Workers in the Nuclear Industry: estimates of radiation-related cancer risks
    E Cardis
    International Agency for Research on Cancer, Lyon, France
    Radiat Res 167:396-416. 2007
    ..Further studies will be important to better assess the role of tobacco and other occupational exposures in our risk estimates...
  6. ncbi Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA-dependent protein kinase catalytic subunit) gene
    Y Yu
    Department of Radiation Oncology, The University of Texas Medical Branch, Galveston 77555, USA
    Cancer Res 61:1820-4. 2001
    ..The data provide the first evidence that naturally arising allelic variation in a mouse DNA damage response gene may associate with IR response and breast cancer risk...
  7. ncbi Radiation effects on breast cancer risk: a pooled analysis of eight cohorts
    Dale L Preston
    Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan
    Radiat Res 158:220-35. 2002
    ..There is also a suggestion that women with some benign breast conditions may be at elevated risk of radiation-associated breast cancer...
  8. ncbi Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): a nested case-control study
    Alice J Sigurdson
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7238, USA
    Lancet 365:2014-23. 2005
    ..We aimed to quantify the long-term risk of thyroid cancer after radiotherapy and chemotherapy...
  9. ncbi Cancer risks from medical radiation
    Elaine Ron
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 7048, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Health Phys 85:47-59. 2003
    ....
  10. ncbi Effect of recent changes in atomic bomb survivor dosimetry on cancer mortality risk estimates
    Dale L Preston
    Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan
    Radiat Res 162:377-89. 2004
    ..Whether or not one makes allowance for this, there is no statistically significant city difference in the estimated cancer risk...
  11. ncbi A cohort study of thyroid cancer and other thyroid diseases after the chornobyl accident: thyroid cancer in Ukraine detected during first screening
    Mykola D Tronko
    Institute of Endocrinology and Metabolism, Kyiv, Ukraine
    J Natl Cancer Inst 98:897-903. 2006
    ..Here we report the results of the first cohort study of thyroid cancer among those exposed as children and adolescents following the Chornobyl accident...
  12. ncbi Cancer mortality risk among workers at the Mayak nuclear complex
    N S Shilnikova
    Southern Urals Biophysics Institute, Ozyorsk, Russia
    Radiat Res 159:787-98. 2003
    ..As dose estimates for the Mayak workers are improved, it should be possible to obtain more precise estimates of solid cancer and leukemia risks from protracted external radiation exposure in this cohort...
  13. ncbi The role of UV induced lesions in skin carcinogenesis: an overview of oncogene and tumor suppressor gene modifications in xeroderma pigmentosum skin tumors
    Leela Daya-Grosjean
    Laboratory of Genetic Instability and Cancer, UPR2169 CNRS, IFR 54, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Mutat Res 571:43-56. 2005
    ....
  14. ncbi Personal sun exposure and risk of non Hodgkin lymphoma: a pooled analysis from the Interlymph Consortium
    Anne Kricker
    School of Public Health, University of Sydney, Sydney, New South Wales, Australia
    Int J Cancer 122:144-54. 2008
    ..Increased recreational sun exposure may protect against NHL...
  15. ncbi Cellular and molecular events leading to the development of skin cancer
    Vladislava O Melnikova
    Department of Immunology, The University of Texas M D Anderson Cancer Center, P O Box 301402, Unit 902, Houston, TX 77030, USA
    Mutat Res 571:91-106. 2005
    ..In this article, we will review some of the cellular and molecular mechanisms involved in initiation and progression of UV-induced skin cancer...
  16. ncbi Health risks of low dose ionizing radiation in humans: a review
    Kedar N Prasad
    Center for Vitamins and Cancer Research, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Exp Biol Med (Maywood) 229:378-82. 2004
    ..Low doses of ionizing radiation should not be considered insignificant for risks of somatic and heritable mutations and neoplastic and nonneoplastic diseases in humans...
  17. ncbi Low-level exposure to radiofrequency electromagnetic fields: health effects and research needs
    M H Repacholi
    World Health Organization, Geneva, Switzerland
    Bioelectromagnetics 19:1-19. 1998
    ..Recent studies that may indicate an increased incidence of cancer in exposed populations should be investigated further...
  18. ncbi Long-term risk of sarcoma following radiation treatment for breast cancer
    A Taghian
    Department of Radiation Therapy, Institut Gustave Roussy, Villejuif, France
    Int J Radiat Oncol Biol Phys 21:361-7. 1991
    ....
  19. ncbi Expression of dominant negative c-jun inhibits ultraviolet B-induced squamous cell carcinoma number and size in an SKH-1 hairless mouse model
    Simon J Cooper
    Department of Radiation Oncology, Arizona Cancer Center, College of Public Health, The University of Arizona, Tucson, AZ, USA
    Mol Cancer Res 1:848-54. 2003
    ..These data show that TAM67 can inhibit UVB-induced squamous cell carcinoma formation, suggesting that AP-1 is a good candidate target for the development of new chemoprevention strategies to prevent sunlight-induced skin cancers...
  20. pmc Latency period of thyroid neoplasia after radiation exposure
    Shoichi Kikuchi
    Department of Surgery, UCSF Affiliated Hospitals, 94143 1674, USA
    Ann Surg 239:536-43. 2004
    ..To determine the temporal sequence for developing benign and malignant thyroid neoplasms after radiation...
  21. ncbi The effect of intensity-modulated radiotherapy on radiation-induced second malignancies
    Jeremy D Ruben
    William Buckland Radiotherapy Centre, Melbourne, Australia Monash University, Melbourne, Australia
    Int J Radiat Oncol Biol Phys 70:1530-6. 2008
    ..To compare intensity-modulated radiotherapy (IMRT) with three-dimensional conformal radiotherapy (3D-CRT) in terms of carcinogenic risk for actual clinical scenarios...
  22. ncbi Iodine deficiency, radiation dose, and the risk of thyroid cancer among children and adolescents in the Bryansk region of Russia following the Chernobyl power station accident
    V V Shakhtarin
    Medical Radiological Research Center of the Russian Academy of Medical Sciences, Obninsk, Russia
    Int J Epidemiol 32:584-91. 2003
    ..No epidemiological studies have been published assessing the modifying effect of iodine deficiency on radiation-induced thyroid cancer following the Chernobyl accident...
  23. ncbi The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
    M A Christophorou
    Cancer Research Institute and Department of Cellular and Molecular Pharmacology, Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA
    Nature 443:214-7. 2006
    ..Such protection is absolutely dependent on p19(ARF)--a tumour suppressor induced not by DNA damage, but by oncogenic disruption of the cell cycle...
  24. ncbi The cancer epidemiology of radiation
    Richard Wakeford
    BNFL, 1100 Daresbury Park, Daresbury, Warrington WA4 4BG, UK
    Oncogene 23:6404-28. 2004
    ....
  25. ncbi The sensitivity of children to electromagnetic fields
    Leeka Kheifets
    Department of Epidemiology, University of California School of Public Health, Los Angeles, California 90095 1772, USA
    Pediatrics 116:e303-13. 2005
    ..It also includes an assessment of the potential susceptibility of children to EMFs and concludes with a recommendation for additional research and the development of precautionary policies in the face of scientific uncertainty...
  26. pmc Long-term results with resection of radiation-induced soft tissue sarcomas
    Charles Cha
    Surgical Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Ann Surg 239:903-9; discussion 909-10. 2004
    ..Radiation-induced sarcoma is a well recognized if uncommon event. The objective of this study is to determine the prevalence and long-term outcome for patients who develop radiation-induced sarcomas...
  27. ncbi The bystander effect in radiation oncogenesis: II. A quantitative model
    D J Brenner
    Center for Radiological Research, Columbia University, New York, New York 10032, USA
    Radiat Res 155:402-8. 2001
    ..2 Gy. At still lower doses, bystander effects may dominate the overall response, possibly leading to an underestimation of low-dose risks extrapolated from intermediate doses, where direct effects dominate...
  28. ncbi Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation
    Shigetoshi Sano
    Department of Dermatology and Social, Osaka University Graduate School of Medicine, Japan
    Cancer Res 65:5720-9. 2005
    ..These data suggest that Stat3 is required for survival and proliferation of keratinocytes following UVB exposure and that Stat3 is tightly regulated as part of a novel protective mechanism against UVB-induced skin cancer...
  29. pmc Risk of cancer after low doses of ionising radiation: retrospective cohort study in 15 countries
    E Cardis
    International Agency for Research on Cancer, Lyons, France
    BMJ 331:77. 2005
    ..To provide direct estimates of risk of cancer after protracted low doses of ionising radiation and to strengthen the scientific basis of radiation protection standards for environmental, occupational, and medical diagnostic exposures...
  30. ncbi Tumors of the nervous system and pituitary gland associated with atomic bomb radiation exposure
    Dale L Preston
    Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan
    J Natl Cancer Inst 94:1555-63. 2002
    ..The risk of developing nervous system tumors following exposure to ionizing radiation is not well quantified. We characterized the incidence of nervous system tumors among atomic bomb survivors as a function of radiation dose...
  31. ncbi Cancer risks from diagnostic radiology
    E J Hall
    Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
    Br J Radiol 81:362-78. 2008
    ..A further issue is the increasing use of CT scans as a screening procedure in asymptomatic patients; at this time, the benefit/risk balance for any of the commonly suggested CT screening techniques has yet to be established...
  32. pmc Cancer risks attributable to low doses of ionizing radiation: assessing what we really know
    David J Brenner
    Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:13761-6. 2003
    ..This linearity assumption is not necessarily the most conservative approach, and it is likely that it will result in an underestimate of some radiation-induced cancer risks and an overestimate of others...
  33. ncbi Cancer risk estimates from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy
    Uwe Schneider
    Division of Medical Physics, Department of Radiation Oncology and Nuclear Medicine, The Triemli Hospital Zürich, 8063 Zurich, Switzerland
    Radiat Environ Biophys 47:253-63. 2008
    ..The work presented here also provides the first direct evidence that the bending over of the solid cancer excess risk dose response curve for the A-bomb survivors, generally observed above 2 Gy, is due to cell killing effects...
  34. pmc Cancer incidence in children and young adults did not increase relative to parental exposure to atomic bombs
    S Izumi
    Department of Statistics, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima 732 0815 Japan
    Br J Cancer 89:1709-13. 2003
    ..97 (95% confidence interval 0.70-1.36). Because of the small number of cases, however, we cannot exclude an increase in cancer incidence at this time...
  35. ncbi The Techa River Cohort: study design and follow-up methods
    M M Kossenko
    Urals Research Center for Radiation Medicine, Chelyabinsk, Russia
    Radiat Res 164:591-601. 2005
    ..The limitations of the study include loss to follow-up due to difficulties in tracing some cohort members and migration and incomplete ascertainment of cause of death...
  36. ncbi Cancer incidence and risk estimation among medical x-ray workers in China, 1950-1995
    J X Wang
    Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjim
    Health Phys 82:455-66. 2002
    ..The RR of leukemia was 1.7 and 1.1 for solid cancer. This means a significant cancer risk can be induced by long term fractionated exposure to ionizing radiation when the cumulative dose reaches a certain level...
  37. ncbi Rare variants of ATM and risk for Hodgkin's disease and radiation-associated breast cancers
    Kenneth Offit
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 8:3813-9. 2002
    ..We next sought to determine the frequency of ATM variants in patients with Hodgkin's lymphoma, regardless of coexisting BC, compared with healthy volunteers...
  38. pmc Arsenic-induced enhancement of ultraviolet radiation carcinogenesis in mouse skin: a dose-response study
    Fredric J Burns
    Department of Environmental Medicine, School of Medicine, New York University, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Environ Health Perspect 112:599-603. 2004
    ....
  39. ncbi Using splines to analyse latency in the Colorado Plateau uranium miners cohort
    M Hauptmann
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD 20892-7244, USA
    J Epidemiol Biostat 6:417-24. 2001
    ..CONCLUSIONS: The proposed spline model is a flexible tool for latency analyses, and extends previously used methods...
  40. pmc Leukaemias and cancers following iodine-131 administration for thyroid cancer
    F de Vathaire
    National Institute of Health and of Medical Research, Unit 351, Institut Gustave Roussy, Villejuif, France
    Br J Cancer 75:734-9. 1997
    ..When digestive tract cancers were excluded, the overall excess relative risk of second cancer per estimated effective sievert received to the whole body was -0.2 (P = 0.6)...
  41. ncbi UV-induced skin damage
    M Ichihashi
    Division of Dermatology, Graduate School of Medicine, Translational Medicine, School of Medicine, Kobe University, Kobe, Japan
    Toxicology 189:21-39. 2003
    ..Finally, possible prevention of UV-induced skin cancer by feeding or topical use of antioxidants, such as polyphenols, vitamin C, and vitamin E, is discussed...
  42. ncbi Incidence of cancer among female flight attendants: a meta-analysis
    Osamu Tokumaru
    Department of Hygiene, National Defense Medical College, Tokorozawa, Japan
    J Travel Med 13:127-32. 2006
    ..A meta-analysis was conducted to study whether the occupational exposure of female flight attendants (FA) increased their relative risk of cancer incidence...
  43. ncbi Occupational risk factors, ultraviolet radiation, and ocular melanoma: a case-control study in France
    P Guenel
    INSERM Unité 88, Hopital National de Saint Maurice, Saint Maurice, France
    Cancer Causes Control 12:451-9. 2001
    ..Ultraviolet radiation has been suspected as a possible cause of ocular melanoma. Because this association is controversial, we examine the role of occupational exposure to ultraviolet radiation on the occurrence of this rare cancer...
  44. ncbi Prostatic carcinosarcoma 15 years after combined external beam radiation and brachytherapy for prostatic adenocarcinoma: a case report
    T Y Tseng
    Division of Urologic Surgery and Duke Prostate Center, Duke University Medical Center, Durham, NC 27704, USA
    Prostate Cancer Prostatic Dis 9:195-7. 2006
    ..The increasing use of such combination high-dose radiation therapy may potentially lead to an increased incidence of secondary malignancies such as prostatic carcinosarcoma in the future...
  45. pmc Incidence of haematopoietic malignancies in US radiologic technologists
    M S Linet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA
    Occup Environ Med 62:861-7. 2005
    ..There are limited data on risks of haematopoietic malignancies associated with protracted low-to-moderate dose radiation...
  46. ncbi The pathogenesis of mesothelioma
    Michele Carbone
    Cancer Immunology Program, Cardinal Bernardin Cancer Center, Department of Pathology, Loyola University Chicago, USA
    Semin Oncol 29:2-17. 2002
    ..Mesothelioma appears to have a complex etiology in which environmental carcinogens (asbestos and erionite), ionizing radiation, viruses, and genetic factors act alone or in concert to cause malignancy...
  47. ncbi Radiation dose, chemotherapy and risk of lung cancer after breast cancer treatment
    Carole Rubino
    Unit of Cancer Epidemiology, National Institute of Health and Medical Research U521 INSERM, Institut Gustave Roussy, Villejuif, France
    Breast Cancer Res Treat 75:15-24. 2002
    ..10) per gray delivered to the site of lung cancer was evidenced. Our results agree with previous studies in favor of an increased risk of lung cancer after radiation therapy for breast cancer...
  48. ncbi Genetic analysis of resistance to radiation lymphomagenesis with recombinant inbred strains of mice
    M Okumoto
    Department of Allied Biological Science, University of Osaka Prefecture, Sakai, Japan
    Cancer Res 50:3848-50. 1990
    ....
  49. ncbi Medical radiation, family history of cancer, and benign breast disease in relation to breast cancer risk in young women, USA
    Deirdre A Hill
    Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles 90033, USA
    Cancer Causes Control 13:711-8. 2002
    ..Some evidence suggests that such risk may be distinctly elevated among women with a family history of breast or ovarian cancer (probably only carriers of specific gene mutations) and women with benign breast disease (BBD)...
  50. ncbi Small-bowel angiosarcoma after pelvic irradiation: a report of two cases
    P Aitola
    Departments of Surgery and Pathology, Tampere University Hospital and Medical School, University of Tampere, P O Box 2000, FIN 33521 Tampere, Finland
    Int J Colorectal Dis 14:308-10. 1999
    ..These cases demonstrate poor prognosis in this disease. Although postirradiation angiosarcoma is a rare condition, its possibility should be kept in mind when operating on previously irradiated patients...
  51. ncbi Effect of breast cancer radiotherapy and cigarette smoking on risk of second primary lung cancer
    Elizabeth L Kaufman
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Clin Oncol 26:392-8. 2008
    ..Prior studies have found that postmastectomy radiotherapy (PMRT) for breast cancer (BC) increases the risk of lung cancer (LC). We explored the joint effects of cigarette smoking and PMRT on LC risk...
  52. ncbi Impact of ionizing radiation and genetic background on mammary tumorigenesis in p53-deficient mice
    M G Backlund
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Cancer Res 61:6577-82. 2001
    ..Furthermore, it suggests that the risk of development of a particular type of tumor by individuals deficient in p53 after exposure to damaging agents can be influenced by modifier alleles...
  53. ncbi High incidence of meningioma among Hiroshima atomic bomb survivors
    T Shintani
    Department of Cancer Cytogenetics, Hiroshima University, Japan
    J Radiat Res 40:49-57. 1999
    ..There was a significant correlation between the incidence and the dose of radiation to the brain. The present findings strongly suggest that meningioma is one of the tumors induced by atomic bombing in Hiroshima...
  54. ncbi Radiation-induced thyroid carcinogenesis as a function of time and dietary iodine supply: an in vivo model of tumorigenesis in the rat
    Carsten Boltze
    Department of Pathology, Otto von Guericke University, D 39120 Magdeburg, Germany
    Endocrinology 143:2584-92. 2002
    ..This model may help to define genetic alterations long before histological changes are detectable...
  55. ncbi Uranium mining in Germany: incidence of occupational diseases 1946-1999
    Christa Schröder
    Hauptverband der gewerblichen Berufsgenossenschaften HVBG, 53754 Sankt Augustin, Germany
    Int Arch Occup Environ Health 75:235-42. 2002
    ..The present study gives an overview of the occurrence of occupational diseases during the mining period as well as after uranium mining was stopped in 1990...
  56. ncbi Case-control study on childhood cancer in the vicinity of nuclear power plants in Germany 1980-2003
    Claudia Spix
    German Childhood Cancer Registry, Institute for Medical Biostatistics, Epidemiology and Informatics, University Mainz, 55101 Mainz, Germany
    Eur J Cancer 44:275-84. 2008
    ..They contrast with the lack of an effect observed or expected from other studies due to low doses from routine nuclear power plant operation...
  57. ncbi Atm haploinsufficiency results in increased sensitivity to sublethal doses of ionizing radiation in mice
    C Barlow
    Nat Genet 21:359-60. 1999
  58. pmc Mortality and cancer incidence following occupational radiation exposure: third analysis of the National Registry for Radiation Workers
    C R Muirhead
    Health Protection Agency, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxon OX11 0RQ, UK
    Br J Cancer 100:206-12. 2009
    ..The cancer risk estimates are consistent with values used to set radiation protection standards...
  59. ncbi Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease
    Lois B Travis
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    JAMA 290:465-75. 2003
    ..Quantitative associations between radiotherapy dose delivered to the breast and administered chemotherapy have not been reported to date in large series, nor has the influence of ovarian exposures on subsequent risk...
  60. ncbi Cancer consequences of the Chernobyl accident: 20 years on
    Elisabeth Cardis
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    J Radiol Prot 26:127-40. 2006
    ....
  61. pmc Dose to the contralateral breast from radiotherapy and risk of second primary breast cancer in the WECARE study
    Marilyn Stovall
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 72:1021-30. 2008
    ..To quantify the risk of second primary breast cancer in the contralateral breast (CB) after radiotherapy (RT) for first breast cancer...
  62. ncbi Late cancer and noncancer risks among Chernobyl emergency workers of Russia
    Victor K Ivanov
    Medical Radiological Research Center of Russian Academy of Medical Sciences, 4 Korolev Street, Obninsk, Kaluga Region, 249036, Russia
    Health Phys 93:470-9. 2007
    ..64; 3.69). Different but overlapping cohorts of Russian emergency workers were used for these estimations. No adjustments were made for recognized risk factors for cerebrovascular diseases. All results should be considered as preliminary...
  63. ncbi Cancer risks among radiologists and radiologic technologists: review of epidemiologic studies
    Shinji Yoshinaga
    Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Radiology 233:313-21. 2004
    ....
  64. ncbi Risk of thyroid cancer after exposure to 131I in childhood
    Elisabeth Cardis
    International Agency for Research on Cancer, Lyon, France
    J Natl Cancer Inst 97:724-32. 2005
    ....
  65. pmc Radiation-induced malignancies following radiotherapy for breast cancer
    R Roychoudhuri
    Thames Cancer Registry, Division of Cancer Studies, Guy s, King s and St Thomas School of Medicine, 1st Floor, Capital House, 42 Weston Street, London SE1 3QD, UK
    Br J Cancer 91:868-72. 2004
    ..99, 95% CI 1.13-9.33), for second breast cancer at 5-10 years (RR 1.34, 95% CI 1.10-1.63) and 15+ years (RR 1.26, 95% CI 1.00-1.59) and oesophageal cancer at 15+ years (RR 2.19, 95% CI 1.10-4.62)...
  66. ncbi Radiation and the microenvironment - tumorigenesis and therapy
    Mary Helen Barcellos-Hoff
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, USA
    Nat Rev Cancer 5:867-75. 2005
    ..These alterations in the microenvironment can contribute to carcinogenesis and alter the tissue response to anticancer therapy. Examples of these responses and their implications are discussed with a view to therapeutic intervention...
  67. ncbi Bone cancer risk in mice exposed to 224Ra: protraction effects from promotion
    W F Heidenreich
    GSF Institute for Radiation Protection, 85764 Neuherberg, Germany
    Radiat Environ Biophys 44:61-7. 2005
    ..13 mGy/day are found to double the baseline initiation rate. At rates above 100 mGy/day, the initiation rate decreases. The clonal expansion rate is doubled at 8 mGy/day, and it levels out at rates beyond 100 mGy/day...
  68. ncbi Biological effects from electromagnetic field exposure and public exposure standards
    Lennart Hardell
    Department of Oncology, University Hospital, SE 701 85 Orebro, Sweden
    Biomed Pharmacother 62:104-9. 2008
    ..Other health impacts associated with exposure to electromagnetic fields not summarized here may be found in the BioInitiative Report at www.bioinitiative.org...
  69. ncbi Chemopreventive effects of alpha-santalol on ultraviolet B radiation-induced skin tumor development in SKH-1 hairless mice
    Chandradhar Dwivedi
    Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD 57007, USA
    Carcinogenesis 27:1917-22. 2006
    ..Together, for the first time, our findings suggest that alpha-santalol could be a potential chemopreventive agent against UVB-induced skin tumor development and, therefore, warrants further investigations...
  70. pmc Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies
    S Darby
    Clinical Trials Service Unit and Epidemiological Studies Unit, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 330:223. 2005
    ..To determine the risk of lung cancer associated with exposure at home to the radioactive disintegration products of naturally occurring radon gas...
  71. ncbi Biomarkers of induced electromagnetic field and cancer
    J Behari
    School of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Indian J Exp Biol 45:77-85. 2007
    ..Finally a mechanism comprising the extremely low frequency and radio frequency (RF)/microwave (MW) modulated field is compared...
  72. ncbi Hepatocellular carcinoma among atomic bomb survivors: significant interaction of radiation with hepatitis C virus infections
    Gerald B Sharp
    Department of Epidemiology, Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima, 732 0815 Japan
    Int J Cancer 103:531-7. 2003
    ....
  73. ncbi Increased risk of squamous cell esophageal cancer after adjuvant radiation therapy for primary breast cancer
    Lydia B Zablotska
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
    Am J Epidemiol 161:330-7. 2005
    ..This finding appears to be a function of the portals used for postmastectomy radiation therapy, which do not expose the lowest third of the esophagus, where adenocarcinomas commonly arise...
  74. ncbi Screening mammography for young women treated with supradiaphragmatic radiation for Hodgkin's lymphoma
    L Lee
    Division of Medical Oncology and Hematology, Massachusetts General Hospital Cancer Center, USA
    Ann Oncol 19:62-7. 2008
    ..Female survivors of Hodgkin's lymphoma (HL) treated with supradiaphragmatic radiation therapy (SRT) are at increased risk of breast cancer (BC), but there is little data on the optimal screening strategy...
  75. ncbi Mammographic breast cancer screening for women previously treated with high breast doses for diseases such as Hodgkin's
    K Faulkner
    Quality Assurance Reference Centre, Wallsend, Tyne and Wear NE28 9ND, UK
    Radiat Prot Dosimetry 117:330-3. 2005
    ..In the United Kingdom, the Department of Health has recommended annual screening for these women...
  76. ncbi Incidence of bone and soft tissue sarcoma after radiotherapy: a cohort study of 295,712 Finnish cancer patients
    Anna Virtanen
    School of Public Health, University of Tampere, Tampere, Finland
    Int J Cancer 118:1017-21. 2006
    ..In conclusion, radiotherapy appears to be associated with an increased risk of developing sarcoma especially among younger patients. Further investigation is needed to clarify the dose-response of the preceding ionizing radiation...
  77. ncbi Understanding estimation of time and age effect-modification of radiation-induced cancer risks among atomic-bomb survivors
    Frederic Lagarde
    Radiation Effects Research Foundation, 5 2 Hijiyama Park, Minami Ku, Hiroshima 732 0815, Japan
    Health Phys 91:608-18. 2006
    ..Also, due to collinearity between these effect-modifier variables, all three models with two of the effect-modifiers necessarily show equivalent fits...
  78. ncbi A prospective study of thyroid nodular disease in children and adolescents in western Poland from 1996 to 2000 and the incidence of thyroid carcinoma relative to iodine deficiency and the Chernobyl disaster
    Marek Niedziela
    Department of Pediatric Endocrinology and Diabetes, University of Medical Sciences in Poznan, Poland
    Pediatr Blood Cancer 42:84-92. 2004
    ..Chernobyl, located in the neighbouring country of Ukraine, suffered a catastrophic nuclear explosion in April 1986...
  79. pmc Childhood cancer in the offspring born in 1921-1984 to US radiologic technologists
    K J Johnson
    Department of Pediatrics, Division of Epidemiology Clinical Research, University of Minnesota, Minneapolis, MN 55455, USA
    Br J Cancer 99:545-50. 2008
    ..8 (95% CI 0.7-4.6). In conclusion, we found no convincing evidence of an increased risk of childhood cancer in the offspring of RTs in association with parental occupational radiation exposure...
  80. ncbi Protein kinase C epsilon is an endogenous photosensitizer that enhances ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas
    Deric L Wheeler
    Department of Human Oncology, Medical School, University of Wisconsin, Madison, Wisconsin 53792, USA
    Cancer Res 64:7756-65. 2004
    ..Taken together, the results indicate that PKCepsilon signals UVR-induced TNFalpha release that is linked, at least in part, to the photosensitivity of PKCepsilon transgenic mice...
  81. pmc Radiation dose, chemotherapy, hormonal treatment and risk of second cancer after breast cancer treatment
    C Rubino
    , Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France
    Br J Cancer 89:840-6. 2003
    ..This relationship was limited to endometrial cancers and did not modify the relationship with radiation dose. Our results suggest that high radiation doses slightly increase the risk of second malignancies after breast cancer...
  82. ncbi Ionizing radiation and tobacco use increases the risk of a subsequent lung carcinoma in women with breast cancer: case-only design
    Michaela Prochazka
    Department of Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE 171 77, Stockholm, Sweden
    J Clin Oncol 23:7467-74. 2005
    ..We accessed the lung dose in relation to different radiotherapy techniques, provided the excess relative risk (ERR) estimate for radiation-associated lung cancer, and evaluated the influence of tobacco use...
  83. ncbi Lumpectomy and breast irradiation for breast cancer arising after previous radiotherapy for Hodgkin's disease or lymphoma
    M Deutsch
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Clin Oncol 24:33-4. 2001
    ..Two women died with distant metastasis but without local recurrence. Breast conservation therapy with radiotherapy is not contraindicated in the woman who has previously been treated with radiotherapy for Hodgkin's disease or lymphoma...
  84. ncbi The possible role of radiofrequency radiation in the development of uveal melanoma
    A Stang
    Institute for Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Essen, Germany
    Epidemiology 12:7-12. 2001
    ..This is the first study describing an association between radiofrequency radiation exposure and uveal melanoma. Several methodologic limitations prevent our results from providing clear evidence on the hypothesized association...
  85. ncbi Lung tumour risk in radon-exposed rats from different experiments: comparative analysis with biologically based models
    J C Kaiser
    Institute of Radiation Protection, GSF National Research Center for Environment and Health, 85764 Neuherberg, Germany
    Radiat Environ Biophys 43:189-201. 2004
    ..In addition, high cumulative exposure exerted lethal effects other than lung cancer on the rats...
  86. ncbi Research on potential radiation risks in areas with nuclear power plants in Japan: leukaemia and malignant lymphoma mortality between 1972 and 1997 in 100 selected municipalities
    Yasuhiko Yoshimoto
    Research Centre for Radiation Safety, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage ward, Chiba 263 8555, Japan
    J Radiol Prot 24:343-68. 2004
    ..Our findings do not support the hypothesis of a leukaemogenic impact of NPPs in Japan...
  87. ncbi Sarcoma after radiation therapy: retrospective multiinstitutional study of 80 histologically confirmed cases. Radiation Therapist and Pathologist Groups of the Fédération Nationale des Centres de Lutte Contre le Cancer
    J L Lagrange
    Radiation Oncology Department, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice 2, France
    Radiology 216:197-205. 2000
    ..To evaluate the best strategy for treatment of sarcoma that occurs after radiation therapy...
  88. pmc Ultrasound-detected thyroid nodule prevalence and radiation dose from fallout
    C E Land
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bthesda, MD 20892 7238, USA
    Radiat Res 169:373-83. 2008
    ..In terms of excess relative risk per unit dose, our dose-response findings for nodule prevalence are comparable to those from populations exposed to medical X rays and to acute radiation from the Hiroshima and Nagasaki atomic bombings...
  89. ncbi Radiation exposure due to local fallout from Soviet atmospheric nuclear weapons testing in Kazakhstan: solid cancer mortality in the Semipalatinsk historical cohort, 1960-1999
    Susanne Bauer
    Federal Office for Radiation Protection, Institute for Radiation Hygiene, Germany
    Radiat Res 164:409-19. 2005
    ..Future epidemiological assessments based on this cohort will benefit from extension of follow-up and ongoing validation of dosimetric data...
  90. ncbi Primary versus radiation-associated craniofacial osteosarcoma: Biologic and clinicopathologic comparisons
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109 0054, USA
    Cancer 107:554-62. 2006
    ..Although most are sporadic, some tumors occur in association with prior radiation therapy. The purpose of the current study was to compare clinicopathologic and prognostic features of primary and radiation-associated osteosarcoma...
  91. ncbi Thyroid disease 60 years after Hiroshima and 20 years after Chernobyl
    John D Boice
    JAMA 295:1060-2. 2006
  92. ncbi Cancer incidence after radiotherapy for skin haemangioma during infancy
    S Lindberg
    Department of Oncology and Radiation Physics, Sahlgrenska University Hospital, , Sweden
    Acta Oncol 34:735-40. 1995
    ..4-18.1). The mean dose in the central nervous system was 0.077 Gy and the ERR for brain tumours was 10.9 per Gy (CI 95% 3.7-20.5). This cohort gives a unique opportunity to analyse long-term effects of low-dose irradiation during infancy...
  93. ncbi A unique tumor antigen produced by a single amino acid substitution
    P A Monach
    Department of Pathology, University of Chicago, Illinois 60637, USA
    Immunity 2:45-59. 1995
    ..These results indicate that this unique tumor antigen is derived from a single amino acid substitution in a cellular protein...
  94. ncbi Breast cancer after treatment of Hodgkin's lymphoma: risk factors that really matter
    Mohamed A Alm El-Din
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 73:69-74. 2009
    ..To evaluate the risk of breast cancer (BC) and the contributing risk factors in women after supradiaphragmatic irradiation (SDI) for Hodgkin's lymphoma (HL)...
  95. pmc Age at exposure to ionising radiation and cancer mortality among Hanford workers: follow up through 1994
    S Wing
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7400, USA
    Occup Environ Med 62:465-72. 2005
    ..Studies of workers at the plutonium production factory in Hanford, WA have led to conflicting conclusions about the role of age at exposure as a modifier of associations between ionising radiation and cancer...
  96. ncbi Lumpectomy and partial breast irradiation for early-stage breast cancer following mantle irradiation for Hodgkin's lymphoma
    Mohamed A Alm El-Din
    Breast Oncology Unit, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Nat Clin Pract Oncol 5:426-9. 2008
    ....
  97. ncbi Relative risks of radiation-associated cancer: comparison of second cancer in therapeutically irradiated populations with the Japanese atomic bomb survivors
    M P Little
    National Radiological Protection Board, Chilton, Didcot, Oxon, UK
    Radiat Environ Biophys 38:267-83. 1999
    ....
  98. ncbi Effects of alpha-santalol on proapoptotic caspases and p53 expression in UVB irradiated mouse skin
    Bhanu L Arasada
    Department of Pharmaceutical Sciences, South Dakota State University, Brookings, SD 57007, USA
    Anticancer Res 28:129-32. 2008
    ..The objective of the present investigation was to study the effects of alpha-santalol on apoptosis proteins and p53 in UVB-induced skin tumor development in SKH-1 mice to elucidate the mechanism of action...
  99. ncbi Clinical and pathologic features of breast cancers in women treated for Hodgkin's disease: a case-control study
    A J Janov
    Division of Population Sciences, Dana Farber Institute, Boston, Massachusetts 02115, USA
    Breast J 7:46-52. 2001
    ..Cases appeared to be at increased risk of developing additional cancers, but we cannot exclude surveillance as a possible contributing factor...
  100. ncbi Radiation-induced cell inactivation can increase the cancer risk
    W F Heidenreich
    GSF Institute for Radiation Protection, Neuherberg, Germany
    Radiat Res 155:870-2. 2001
    ..A major part of the radon-induced lung cancers in the Colorado miners can be explained by a moderate increase in the replacement probability...
  101. ncbi Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells
    L B Smilenov
    Center for Radiological Research, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Cancer Res 61:5710-3. 2001
    ..From these data we suggest that Ataxia Telangiectasia heterozygotes could indeed represent a societally-significant radiosensitive human subpopulation...

Research Grants73

  1. A new ultra-low field in-vivo EPR technology for biomedical applications
    Inseob Hahn; Fiscal Year: 2011
    ....
  2. A new ultra-low field in-vivo EPR technology for biomedical applications
    Inseob Hahn; Fiscal Year: 2012
    ....
  3. Radiation and Genomic Instability in Finite Lifespan Human Mammary Epithelium
    Amy Kronenberg; Fiscal Year: 2010
    ....
  4. Rapid Robust Pediatric MRI
    Shreyas S Vasanawala; Fiscal Year: 2013
    ....
  5. Automated Radiation Monitoring and Decision Support to Reduce Cumulative Exposure
    Aaron Sodickson; Fiscal Year: 2012
    ..In the long run, with universal adoption of standardized electronic medical records, this work will pave the way for large-scale epidemiologic studies to directly test the underlying cancer risk models of low dose radiation exposure. ..
  6. IN VIVO INDUCTION AND REPAIR OF GENOMIC INSTABILITY
    ANTONE BROOKS; Fiscal Year: 2000
    ....
  7. GENOMIC INSTABILITY IN HIGH LET CARCINOGENESIS
    Robert Ullrich; Fiscal Year: 2001
    ....
  8. High Stability Accelerator for Sub-Cellular Microbeam
    David Brenner; Fiscal Year: 2003
    ..We have considerably more demand for microbeam time than we can cope with, primarily because of limited physicist manpower. ..
  9. RADIOLOGICAL RESEARCH ACCELERATOR FACILITY (RARAF)
    David Brenner; Fiscal Year: 2002
    ..abstract_text> ..
  10. Cancer Risks Attributable To Radiation from Pediatric CT
    David Brenner; Fiscal Year: 2006
    ..The target audiences will be radiologists, pediatricians, family physicians, and the CT industry. We will use telephone interviews supplemented with survey questions, to aid in web content decisions. ..
  11. Cancer Risk Assessment: Is There New Science to Apply?
    Richard Bull; Fiscal Year: 2002
    ..A summary of the meeting will be prepared and this along with any conclusions and recommendations will be submitted to a peer-reviewed journal for publication. ..
  12. HIGH ENERGY IONS AND GENOMIC INSTABILITY
    Eric Hall; Fiscal Year: 2001
    ....
  13. Genetic Consequences of Therapies for Cancer
    John Boice; Fiscal Year: 2009
    ..abstract_text> ..
  14. IOWA AND MISSOURI RADON LUNG CANCER STUDIES
    R Field; Fiscal Year: 2007
    ..The pooling of data between two large-scale epidemiologic studies from a similar geographic area, Iowa and Missouri, will allow us to increase sample size and statistical power. ..
  15. POPULATION RISK MODEL FOR ALPHA-INDUCED BONE NEOPLASMS
    RAY LLOYD; Fiscal Year: 2005
    ..7) To develop a general risk model for alpha-induced neoplasms. For this, data in human and experimental studies on radium will be used as a basis for extrapolation to other alpha-emitting nuclides. ..
  16. GORDON RESEARCH CONFERENCE ON MAMMARY GLAND BIOLOGY
    MARY BARCELLOS HOFF; Fiscal Year: 2003
    ..abstract_text> ..
  17. The Risk of Cancer in Fanconi Anemia Heterozygotes
    Marianne Berwick; Fiscal Year: 2005
    ..Analyses will be undertaken to evaluate the role of Fanconi anemia heterozygosity for cancer. If carriers are found to be at increased risk, this information can be used to target individuals for cancer prevention strategies. ..
  18. Prospective Investigation for Pulmonary Embolism Dx III
    Paul Stein; Fiscal Year: 2008
    ..abstract_text> ..
  19. Air Pollution and Adverse Birth Outcomes
    Beate Ritz; Fiscal Year: 2004
    ..abstract_text> ..
  20. Updating Chromosome Aberration Simulator (CAS) Software
    Rainer Sachs; Fiscal Year: 2006
    ..An interdisciplinary team has been assembled for this project. The grant would ensure that a computer resource important to the radiation cytogenetics community is kept fully current and readily available. ..
  21. Regulation of BCL-2 and Tumorigenicity
    Marc Mendonca; Fiscal Year: 2006
    ..abstract_text> ..
  22. Imaging & Localizing Device Using the Barkhausen Effect
    John Dicello; Fiscal Year: 2003
    ..Existing reconstruction techniques will be adapted to provide absolute spatial information. With fusion, images can be combined with CT, MRI, or PET for anatomical and physiological information. ..
  23. Repair & Prevention of DNA Damage & Breast Cancer Risk
    Roy Shore; Fiscal Year: 2005
    ..The polymorphisms either have not been studied previously in relation to breast cancer risk, or their contribution to risk is uncertain because of limitations in previous studies. ..
  24. CYTOGENETIC MODELS FOR ASSESSING LOW DOSE RADIATION RISK
    Rainer Sachs; Fiscal Year: 2001
    ..By studying molecular, mechanisms relevant to low doses and low dose-rates quantitatively the project will help firm-up risk estimates and make them more credible. ..
  25. 16th World Congress of Epidemiology
    David Savitz; Fiscal Year: 2002
    ..Symposia and scientific sessions for poster and oral presentations will provide a dynamic forum for discussion in all of these areas. ..
  26. RADIATION INDUCED THYROID CANCER
    ARTHUR SCHNEIDER; Fiscal Year: 2002
    ..These studies will focus on rearrangements of the ret protooncogene in thyroid neoplasms and the NF2 tumor suppressor gene in neural tumors. ..
  27. Registry Study of Parkinsons Disease in Denmark
    Beate R Ritz; Fiscal Year: 2010
    ..The proposed research cannot be performed in the US due to a lack of population PD registries that would provide access to such a large number of cases and valid methods for control recruitment from the general population. ..
  28. Ergonomic Interventions for Garment Work
    Beate Ritz; Fiscal Year: 2004
    ..This study will provide employers, employees and public agencies with evidence of the effectiveness of ergonomic interventions in order to guide health and safety policy. ..
  29. Solar Exposure and Melanoma Survival
    Marianne Berwick; Fiscal Year: 2009
    ..2. Determine whether functional polymorphic variants in the vitamin D receptor affect survival from melanoma. 3. Investigate the interaction of lifetime solar exposure and polymorphisms in VDR and its effect on survival. ..
  30. PROSPECTIVE INVESTIGATION OF PULMONARY EMBOLISM DX-II
    Paul Stein; Fiscal Year: 2003
    ..4) The team of investigators is strong, and has collaborated previously in successful research in PE. ..
  31. CARP, A Novel Cell Death Regulator
    Wafik El Deiry; Fiscal Year: 2006
    ..Specific Aim 3: To study the functional consequences of perturbing or blocking CARP expression. These studies should provide novel insights into the cellular control of the extrinsic pathway of apoptosis. ..
  32. PGE2 Receptor Function in Skin
    Alice P Pentland; Fiscal Year: 2010
    ..at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  33. TGFb Regulation of ER Receptor Positive Mammary Cells
    MARY BARCELLOS HOFF; Fiscal Year: 2006
    ..3: To determine whether TGF-beta regulation of the ER+ subpopulation contributes to progression and/or features of preneoplastic lesions. ..
  34. Magnetic Sorter Channels for Stem Cells
    Paul Todd; Fiscal Year: 2006
    ..abstract_text> ..
  35. Meningioma: Risk Factors and Quality of Life
    Melissa L Bondy; Fiscal Year: 2010
    ..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningiomas. ..
  36. CARCINOGENIC INTERACTIONS OF RADIATION AND CHEMICALS
    Robert Ullrich; Fiscal Year: 2007
    ..abstract_text> ..
  37. Microenvironmental Control of the Radiation Response
    Adam Dicker; Fiscal Year: 2007
    ..The use of these tools in organotypic reconstructs promises to provide novel information about cell survival signaling in an 'in vivo' context with clear implications for therapeutic intervention. ..
  38. COMMUNITY HEALTH & ENVIRONMENTAL REAWAKENING
    Steven Wing; Fiscal Year: 2007
    ....
  39. Prediction of Second Cancer Risks for Children Treated with Proton - vs. - Photon
    Wayne D Newhauser; Fiscal Year: 2010
    ..In the future, we expect that the lower-risk treatments will result in fewer second cancers and this will translate into longer, higher-quality lives for survivors of childhood cancer (presently 270,000 persons in the United States). ..
  40. Bayesian Models for Gene Expression with Microarray Data
    Bani Mallick; Fiscal Year: 2007
    ....
  41. Gene Therapy Reduction of Radiotherapy Esophagitis
    Joel S Greenberger; Fiscal Year: 2010
    ..These studies should elucidate the molecular mechanism of induction of damage to engrafting marrow origin, epithelial stem cells by the irradiated esophageal microenvironment and identify new targets for therapeutic intervention. ..
  42. Data Coordinating Center for Sleep Heart Health
    Marie Diener West; Fiscal Year: 2007
    ..abstract_text> ..
  43. Tobacco Prevention/Cessation Education: Medical Students
    Alan Geller; Fiscal Year: 2006
    ..modules, plans for integration, and faculty training Aim3 - Conduct trial implementation Aim4 - Conduct a comprehensive, formative, process and impact evaluation Aim5 - Disseminate teaching guides to other medical schools ..
  44. Unique BRCA1 transcriptional response leading to repair
    Wafik El Deiry; Fiscal Year: 2006
    ..Our studies will increase our understanding of the mechanism of action of BRCA1 and may provide novel strategies for therapeutic design, for example by targeting DDB2. ..
  45. CLINICAL PET AND LABORATORY STUDIES OF ADRENERGIC TUMORS
    Barry Shulkin; Fiscal Year: 2002
    ....
  46. Vaccine therapy of congenital adrenal Hyperplasia
    Scott Rivkees; Fiscal Year: 2003
    ..We also anticipate being able to extend this novel approach to the treatment of other receptor-mediated endocrine disorders, such as hyperthyroidism. ..
  47. ACTIVE LIFE EXPECTANCY IN OLD AND OLDEST OLD POPULATIONS
    Kenneth Manton; Fiscal Year: 2002
    ..Using the detailed measures of disability made in each NLTCS wave, the project will examine more refined changes in specific types and intensity of disability and differences over age, race, gender, and education. ..
  48. MECHANISMS OF INDUCTION OF SKIN CANCERS BY UV LIGHT
    HONNAVARA ANANTHASWAMY; Fiscal Year: 2004
    ..In addition, the results may suggest that similar mechanisms be involved in skin cancer development in humans. ..
  49. Genetic Mutations in Gliomatosis Cerebri
    Marcus Ware; Fiscal Year: 2004
    ..We shall use this data to determine if there are specific patterns of chromosome aberrations that are characteristic of GC. Our final goal is to compare copy-number aberrations seen in GC to those seen in other non-GC astrocytic tumors. ..
  50. Prevention of Skin Cancer by Scutellaria Baicalensis
    Huachen Wei; Fiscal Year: 2004
    ..abstract_text> ..
  51. KILLER/DR5 AND TUMORIGENESIS
    Wafik El Deiry; Fiscal Year: 2001
    ..These experiments could lead to novel strategies for anti-cancer therapy. ..
  52. RASSF1 Tumor Suppressor Gene
    GERD PFEIFER; Fiscal Year: 2005
    ..The effect of RASSF1 expression on RAS signaling pathways will be studied. We will examine if RASSF1A, alone or in combination with activated RAS, induces cell death (apoptosis). ..
  53. MOLECULAR EPIDEMIOLOGY OF GLIOMAS
    Melissa Bondy; Fiscal Year: 2004
    ..no abstract available ..
  54. ACTIVATING MULTIETHNIC YOUTH FOR SMOKING PREVENTION
    Karen Glanz; Fiscal Year: 2002
    ..abstract_text> ..
  55. Effects of TPA on Leukemia and Solid Tumors
    Allan Conney; Fiscal Year: 2006
    ..Blood levels of TPA that are associated with inhibition of tumor growth will be determined. The effect of inhibitors of tumor growth on proliferation and apoptosis in the tumors will be determined. ..
  56. CB1 Receptor Action on the Developing Hippocampus
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will result in new insights into the potential effects of cannabinoid action on the developing brain. ..
  57. Eugene P. Cronkite Symposium
    Nicholas Dainiak; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  58. BYSTANDER EFFECTS AND X RAY INDUCED GENOMIC INSTABILITY
    William Morgan; Fiscal Year: 2004
    ..Identifying the BSEF would enhance our understanding of how radiation exerts its deleterious effects and could directly impact risk estimation for radiation exposure. ..
  59. c-erbB-2 and Risk of Contralateral Breast Cancer
    Christopher Li; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  60. Cardiovascular Risk 50 Years After Thymic Irradiation
    Michael Adams; Fiscal Year: 2007
    ..This group of individuals, if shown to be at high risk, constitutes a potentially huge number of persons who may benefit from additional preventive measures. ..
  61. Targeted Alpha-Particle Emitter Therapy of Metastases
    George Sgouros; Fiscal Year: 2009
    ..The work described in this application is intended to develop and evaluate such an approach. ..
  62. Mechanisms of Radiation-Induced Genomic Istability
    William Morgan; Fiscal Year: 2005
    ....
  63. Protein Biomarkers of Cancer Risk in Older Persons
    Christopher Li; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  64. Prevention of skin cancer by green tea polyphenols
    Santosh Katiyar; Fiscal Year: 2009
    ..Importantly, worldwide interest in green tea as a cancer chemopreventive agent for humans is increasing because it is non-toxic, affordable, popular beverage and is effective in a wide range of organs. ..
  65. CANCER EPIDEMIOLOGY
    Leslie Robison; Fiscal Year: 2002
    ..Extensive data bases are available to trainees as well as current studies. Finally, the University has recently established a new Cancer Center with a strong program in cancer prevention and etiology. ..
  66. VITAMIN D AND THE DIFFERENTIATION OF KERATINOCYTES
    Daniel Bikle; Fiscal Year: 2003
    ..abstract_text> ..
  67. REGULATION OF INTESTINAL CALCIUM TRANSPORT BY VITAMIN D
    Daniel Bikle; Fiscal Year: 2001
    ..These manipulations will all be tested for their ability to block 1,25D-stimulated calcium transport. ..
  68. PROJECT ALLIFE-EXERCISE AND LEUKEMIA SURVIVORS
    Kevin Oeffinger; Fiscal Year: 2006
    ..This study will represent the first clinical trial aimed at increasing physical activity in leukemia survivors and will advance our understanding of this vulnerable population. ..
  69. Role of HPV16 E7/E2F6 interaction in viral oncogenesis
    Margaret McLaughlin Drubin; Fiscal Year: 2006
    ..These studies will further the understanding of how viral proteins interact with cellular factors to induce cancer. [unreadable] [unreadable] [unreadable] [unreadable]..
  70. Proanthocyanidins: Novel Skin Cancer Preventive Agent
    Santosh Katiyar; Fiscal Year: 2006
    ..Prevention of skin cancer risk will result to protect and prolong the human health and lives. ..
  71. Prevention of Photocarcinogenesis by antioxidant
    Santosh Katiyar; Fiscal Year: 2003
    ..abstract_text> ..
  72. Trace elements among Iowa pesticide applicators
    Leslie Dennis; Fiscal Year: 2004
    ..abstract_text> ..