precancerous conditions

Summary

Summary: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)

Top Publications

  1. ncbi Nomenclature and classification of potentially malignant disorders of the oral mucosa
    S Warnakulasuriya
    Department of Oral Medicine, King s College London Dental Institute at Guy s, Denmark Hill Campus, Caldecot Road, London, UK
    J Oral Pathol Med 36:575-80. 2007
  2. ncbi Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
    Vassilis G Gorgoulis
    Department of Histology and Embryology, School of Medicine, University of Athens, Athens GR 11527, Greece
    Nature 434:907-13. 2005
  3. pmc Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa
    M Dinis-Ribeiro
    Department of Gastroenterology, Portuguese Oncology Institute of Coimbra, Portugal
    Endoscopy 44:74-94. 2012
  4. ncbi Oral epithelial dysplasia classification systems: predictive value, utility, weaknesses and scope for improvement
    S Warnakulasuriya
    Department of Oral Medicine, King s College Dental Institute at Guy s, King s and St Thomas Hospitals, London, UK
    J Oral Pathol Med 37:127-33. 2008
  5. pmc Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
    John P Morris
    Diabetes Center, Department of Medicine, UCSF, San Francisco, California 94143, USA
    J Clin Invest 120:508-20. 2010
  6. pmc Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis
    Sun Lee
    Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
    Am J Pathol 163:1371-8. 2003
  7. pmc Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis
    S A Belinsky
    Lovelace Respiratory Research Institute, Lung Cancer Program, P O Box 5890, Albuquerque, NM 87185, USA
    Proc Natl Acad Sci U S A 95:11891-6. 1998
  8. ncbi Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions
    R H Hruban
    Departments of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
    Am J Surg Pathol 25:579-86. 2001
  9. ncbi Profiling early head and neck cancer
    Keith D Hunter
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland
    Nat Rev Cancer 5:127-35. 2005
  10. ncbi Update on the serrated pathway to colorectal carcinoma
    Dale C Snover
    Department of Pathology, Fairview Southdale Hospital, Hibbing, MN 55746, USA
    Hum Pathol 42:1-10. 2011

Detail Information

Publications300 found, 100 shown here

  1. ncbi Nomenclature and classification of potentially malignant disorders of the oral mucosa
    S Warnakulasuriya
    Department of Oral Medicine, King s College London Dental Institute at Guy s, Denmark Hill Campus, Caldecot Road, London, UK
    J Oral Pathol Med 36:575-80. 2007
    ..The terminology presented in this report reflects our best understanding of multi-step carcinogenesis in the oral mucosa, and aspires to engender consistency in use...
  2. ncbi Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
    Vassilis G Gorgoulis
    Department of Histology and Embryology, School of Medicine, University of Athens, Athens GR 11527, Greece
    Nature 434:907-13. 2005
    ..We propose that, from its earliest stages, cancer development is associated with DNA replication stress, which leads to DNA double-strand breaks, genomic instability and selective pressure for p53 mutations...
  3. pmc Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa
    M Dinis-Ribeiro
    Department of Gastroenterology, Portuguese Oncology Institute of Coimbra, Portugal
    Endoscopy 44:74-94. 2012
    ..have therefore combined efforts to develop evidence-based guidelines on the management of patients with precancerous conditions and lesions of the stomach (termed MAPS)...
  4. ncbi Oral epithelial dysplasia classification systems: predictive value, utility, weaknesses and scope for improvement
    S Warnakulasuriya
    Department of Oral Medicine, King s College Dental Institute at Guy s, King s and St Thomas Hospitals, London, UK
    J Oral Pathol Med 37:127-33. 2008
    ....
  5. pmc Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
    John P Morris
    Diabetes Center, Department of Medicine, UCSF, San Francisco, California 94143, USA
    J Clin Invest 120:508-20. 2010
    ....
  6. pmc Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis
    Sun Lee
    Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
    Am J Pathol 163:1371-8. 2003
    ..CpG island methylation of E-cadherin or GSTP1 might serve as a potential biomarker for prognostication of HCC patients...
  7. pmc Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis
    S A Belinsky
    Lovelace Respiratory Research Institute, Lung Cancer Program, P O Box 5890, Albuquerque, NM 87185, USA
    Proc Natl Acad Sci U S A 95:11891-6. 1998
    ..These studies show for the first time that an epigenetic alteration, aberrant methylation of the p16 gene, can be an early event in lung cancer and may constitute a new biomarker for early detection and monitoring of prevention trials...
  8. ncbi Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions
    R H Hruban
    Departments of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
    Am J Surg Pathol 25:579-86. 2001
    ..The acceptance of a standard classification system will facilitate the study of pancreatic duct lesions, and will lead ultimately to a better understanding of their biologic importance...
  9. ncbi Profiling early head and neck cancer
    Keith D Hunter
    The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, Scotland
    Nat Rev Cancer 5:127-35. 2005
    ..Recent advances have begun to elucidate the different aetiologies of HNSCCs in relation to previous pre-malignancies and to identify which pre-malignant lesions are likely to progress to malignancy...
  10. ncbi Update on the serrated pathway to colorectal carcinoma
    Dale C Snover
    Department of Pathology, Fairview Southdale Hospital, Hibbing, MN 55746, USA
    Hum Pathol 42:1-10. 2011
    ..This article reviews the various pathways to colorectal carcinoma with emphasis on the serrated pathway and evaluates the implications of this pathway for colorectal carcinomas screening programs...
  11. ncbi Oral cancer and precancerous lesions
    Brad W Neville
    Department of Stomatology, College of Dental Medicine, Medical University of South Carolina, Charleston, USA
    CA Cancer J Clin 52:195-215. 2002
    ..The purpose of this article is to review the clinical features of oral cancer and premalignant oral lesions, with an emphasis on early detection...
  12. ncbi Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells
    N Murata-Kamiya
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Oncogene 26:4617-26. 2007
    ..pylori CagA plays an important role in the development of intestinal metaplasia, a premalignant transdifferentiation of gastric epithelial cells from which intestinal-type gastric adenocarcinoma arises...
  13. ncbi Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management
    Isaac van der Waal
    VU University Medical Center Academic Centre for Dentistry Amsterdam, Department of Oral and Maxillofacial Surgery Pathology, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Oral Oncol 45:317-23. 2009
    ..Finally, brief attention has been paid to oral submucous fibrosis, actinic cheilitis, some inherited cancer syndromes and immunodeficiency in relation to cancer predisposition...
  14. ncbi Evaluation of an autofluorescence based imaging system (VELscope™) in the detection of oral potentially malignant disorders and benign keratoses
    K H Awan
    Oral Medicine, Department of Clinical and Diagnostic Sciences, King s College London Dental Institute, United Kingdom
    Oral Oncol 47:274-7. 2011
    ..1% and 15.3% respectively. While VELscope was useful in confirming the presence of oral leukoplakia and erythroplakia and other oral mucosal disorders, the device was unable to discriminate high-risk from low-risk lesions...
  15. ncbi Genome-wide DNA methylation profiles in precancerous conditions and cancers
    Yae Kanai
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 101:36-45. 2010
    ..Therefore, genome-wide DNA methylation profiling may provide optimal indicators for carcinogenetic risk estimation and prognostication, and thus provide an avenue for cancer prevention and therapy on an individual basis...
  16. ncbi Gastric cancer risk in patients with premalignant gastric lesions: a nationwide cohort study in the Netherlands
    Annemarie C de Vries
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Gastroenterology 134:945-52. 2008
    ..Quantification of gastric cancer risk in patients with premalignant gastric lesions is unclear, however. Consequently, endoscopic surveillance is controversial, especially in Western populations...
  17. ncbi Environmental factors in Helicobacter pylori-related gastric precancerous lesions in Venezuela
    Ikuko Kato
    Karmanos Cancer Institute Department of Pathology, Wayne State University, Detroit MI, USA
    Cancer Epidemiol Biomarkers Prev 13:468-76. 2004
    ..However, there were no inverse associations with plasma antioxidant vitamins. These findings offer important public health implications in preventing progression of HP-associated gastric precancerous lesions in high-risk populations...
  18. pmc Short term persistence of human papillomavirus and risk of cervical precancer and cancer: population based cohort study
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    BMJ 339:b2569. 2009
    ....
  19. ncbi Up and downregulation of p16(Ink4a) expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer
    Lydia Kriegl
    Department of Pathology, Ludwig Maximilians Universität LMU, Munich, Germany
    Mod Pathol 24:1015-22. 2011
    ..Loss of p16(Ink4a) expression occurs during malignant transformation and is caused mainly by aberrant methylation of the CDKN2A promoter...
  20. pmc Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
    Jean Paul De La O
    Department of Human Genetics, University of Utah, 15 North 2030 East, Room 2100, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 105:18907-12. 2008
    ..At the cellular level, Notch/Kras coactivation promotes rapid reprogramming of acinar cells to a duct-like phenotype, providing an explanation for how a characteristically ductal tumor can arise from nonductal acinar cells...
  21. ncbi Transgenic Polyoma middle-T mice model premalignant mammary disease
    J E Maglione
    Department of Medicine, Cancer Center, School of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cancer Res 61:8298-305. 2001
    ..These results support the use of PyV-mT transgenic mice as a model for investigating the multistep progression of malignant mammary tumorigenesis and metastasis...
  22. ncbi A 2-year prospective study of human papillomavirus persistence among women with a cytological diagnosis of atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion
    Martyn Plummer
    International Agency for Research on Cancer, Lyon, France
    J Infect Dis 195:1582-9. 2007
    ..Most infections and associated lesions clear spontaneously. It is important to define the determinants and timing of clearance, so that viral persistence can be recognized and managed...
  23. ncbi Biomarkers in dysplasia of the oral cavity: a systematic review
    Joel Smith
    Institute of Head and Neck Studies and Education, Department of Otorhinolaryngology Head and Neck Surgery, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry, United Kingdom
    Oral Oncol 45:647-53. 2009
    ..Research into this field should concentrate on longitudinal design, with pooling of data from multiple centres to achieve larger cohorts. We recommend standardisation of definitions to allow appropriate comparisons to be made...
  24. ncbi Methylation of p16 CpG island associated with malignant progression of oral epithelial dysplasia: a prospective cohort study
    Jie Cao
    Peking University School and Hospital of Stomatology, Beijing, China
    Clin Cancer Res 15:5178-83. 2009
    ..To investigate the predictive value of p16 methylation on malignant potential in oral epithelial dysplasia, we carried out the prospective cohort study...
  25. pmc The field of tissue injury in the lung and airway
    Katrina Steiling
    The Pulmonary Center, Boston University Medical Center, Boston, Massachusetts 02118, USA
    Cancer Prev Res (Phila) 1:396-403. 2008
    ....
  26. ncbi Genetics/epigenetics of oral premalignancy: current status and future research
    M W Lingen
    Department of Pathology, The University of Chicago Pritzker School of Medicine, Chicago, IL, USA
    Oral Dis 17:7-22. 2011
    ..In addition, recommendations for future research studies directed at defining the predictive capacity of specific biomarkers in this modeling are presented...
  27. ncbi Minichromosome maintenance proteins as biological markers of dysplasia and malignancy
    A Freeman
    Department of Pathology, University of Cambridge, United Kingdom
    Clin Cancer Res 5:2121-32. 1999
    ....
  28. ncbi Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway
    Hiroko Oshima
    Division of Genetics, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Gastroenterology 131:1086-95. 2006
    ..To investigate the role of Wnt and PGE(2) in gastric cancer, we have generated transgenic mice that activate both pathways and examined their phenotypes...
  29. ncbi A novel pit pattern identifies the precursor of colorectal cancer derived from sessile serrated adenoma
    Tomoaki Kimura
    Department of Gastroenterology, Akita Red Cross Hospital, Akita, Japan
    Am J Gastroenterol 107:460-9. 2012
    ..Consequently, colonoscopic identification of SSAs has important implications for preventing CRCs, but accurate endoscopic diagnosis is often difficult. Our aim was to clarify which endoscopic findings are specific to SSAs...
  30. pmc Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia
    Liqin Zhu
    Department of Biological Sciences and the Purdue Cancer Center, Purdue University, Hansen Life Sciences Research Building, West Lafayette, IN 47907 2064, USA
    Am J Pathol 171:263-73. 2007
    ..Identification of an acinar contribution to PanIN formation offers new directions for successful targeted therapeutic approaches to combat this disease...
  31. ncbi Adjunctive techniques for oral cancer examination and lesion diagnosis: a systematic review of the literature
    Lauren L Patton
    Department of Dental Ecology, General Practice Residency Program, School of Dentistry, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7450, USA
    J Am Dent Assoc 139:896-905; quiz 993-4. 2008
    ..Adjunctive techniques that may facilitate the early detection of oral premalignant and malignant lesions (OPML) have emerged in the past decades...
  32. pmc Central role of c-Myc during malignant conversion in human hepatocarcinogenesis
    Pal Kaposi-Novak
    Laboratory of Experimental Carcinogenesis, National Cancer Institute, Center for Cancer Research, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 69:2775-82. 2009
    ....
  33. ncbi Oxygenated hemoglobin diffuse reflectance ratio for in vivo detection of oral pre-cancer
    Rupananda Mallia
    Centre for Earth Science Studies, Biophotonics Laboratory, Trivandrum, India
    J Biomed Opt 13:041306. 2008
    ....
  34. ncbi Fields and field cancerization: the preneoplastic origins of cancer: asymptomatic hyperplastic fields are precursors of neoplasia, and their progression to tumors can be tracked by saturation density in culture
    Harry Rubin
    Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, USA
    Bioessays 33:224-31. 2011
    ....
  35. pmc Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy
    Hariharan Subramanian
    Biomedical Engineering Department, Northwestern University, Evanston, Illinois, USA
    Cancer Res 69:5357-63. 2009
    ..These results have important implications in that PWS can be used as a new method to identify patients harboring malignant or premalignant tumors by interrogating easily accessible tissue sites distant from the location of the lesion...
  36. ncbi Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program
    Yongping G Crawford
    Department of Pathology and Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94143, USA
    Cancer Cell 5:263-73. 2004
    ..These putative precursors can be selectively eliminated upon exposure to COX-2 inhibitors in vitro...
  37. ncbi Incessant ovulation, inflammation and epithelial ovarian carcinogenesis: revisiting old hypotheses
    Jean S Fleming
    Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Biomedical Sciences, Griffith University Nathan Campus, Nathan, QLD 4111, Australia
    Mol Cell Endocrinol 247:4-21. 2006
    ..The emergence of laser-capture microdissection and expression profiling by microarray technologies offers the promise of defining these pathways more accurately, as well as providing us with the tools for earlier diagnosis...
  38. ncbi A novel optical imaging method for the early detection, quantitative grading, and mapping of cancerous and precancerous lesions of cervix
    C Balas
    FO R T H Institute of Electronic Structure and LASER, P O Box 1527, 71110 Heraklion Crete Greece
    IEEE Trans Biomed Eng 48:96-104. 2001
    ..The demonstrated improved sensitivity and specificity highlight the potential of the method in both clinical research and noninvasive diagnosis...
  39. ncbi Multistate and multifactorial progression of gastric cancer: results from community-based mass screening for gastric cancer
    Cheng Ying Liu
    Health Bureau of Lienchiang County, Matzu, Taiwan
    J Med Screen 13:S2-5. 2006
    ..Further progression to AG and IM was significantly accelerated in those testing positive for PGI and in those with a history of upper gastrointestinal disease...
  40. ncbi Expression of TERT in early premalignant lesions and a subset of cells in normal tissues
    K A Kolquist
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nat Genet 19:182-6. 1998
    ....
  41. pmc Detection of p53 mutations in precancerous gastric tissue
    C Morgan
    Human Molecular Pathology Group, Swansea Clinical School, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK
    Br J Cancer 89:1314-9. 2003
    ..pylori-positive and -negative groups. However, a small subpopulation of the H. pylori-negative patients had much higher levels of free radicals. This suggests a more prominent role for other factors in ROS production...
  42. ncbi Miniprobe confocal laser microscopy for the detection of invisible neoplasia in patients with Barrett's oesophagus
    H Pohl
    Central Interdisciplinary Endoscopy Unit, Department of Gastroenterology, Hepatology and Metabolic Diseases, Virchow Clinic Campus, Charité Medical University of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Gut 57:1648-53. 2008
    ..We evaluated in vivo miniprobe confocal laser microscopy (CLM) for the detection of invisible Barrett's neoplasia...
  43. pmc Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer
    Frank McCaughan
    Centre for Respiratory Research, Royal Free and University College Medical School, London, United Kingdom
    Am J Respir Crit Care Med 182:83-91. 2010
    ..For technical reasons, previous attempts to analyze 3q amplification in preinvasive lesions have focused on small numbers of predetermined candidate loci rather than an unbiased survey of copy-number variation...
  44. ncbi Follicle-stimulating hormone activates mitogen-activated protein kinase in preneoplastic and neoplastic ovarian surface epithelial cells
    Kyung Chul Choi
    Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V5
    J Clin Endocrinol Metab 87:2245-53. 2002
    ..These results suggest that the MAPK cascade may be involved in cellular functions such as growth stimulation in response to FSH in preneoplastic and neoplastic OSE cells...
  45. ncbi Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas
    Dun Fa Peng
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 96:403-8. 2005
    ....
  46. ncbi Curcumin down regulates smokeless tobacco-induced NF-kappaB activation and COX-2 expression in human oral premalignant and cancer cells
    Chhavi Sharma
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Toxicology 228:1-15. 2006
    ..In conclusion, our findings demonstrate for the first time that curcumin downregulates STE (khaini) or NNK-induced NF-kappaB and COX-2 in oral premalignant and cancer cells in vitro...
  47. ncbi Locked nucleic acid in situ hybridization analysis of miR-21 expression during colorectal cancer development
    Nobutake Yamamichi
    Department of Microbiology and Immunology, Division of Host Parasite Interaction, Faculty of Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Clin Cancer Res 15:4009-16. 2009
    ..To better understand microRNA miR-21 function in carcinogenesis, we analyzed miR-21 expression patterns in different stages of colorectal cancer development using in situ hybridization (ISH)...
  48. ncbi The new World Health Organization classification of lung tumours
    E Brambilla
    Service de Pathologie Cellulaire, Centre Hospitalier Universitaire de Grenoble, France
    Eur Respir J 18:1059-68. 2001
    ....
  49. pmc Multiple novel prostate cancer predisposition loci confirmed by an international study: the PRACTICAL Consortium
    Zsofia Kote-Jarai
    Section of Cancer Genetics Team, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:2052-61. 2008
    ..This study provides strong confirmation of these susceptibility loci in multiple populations and shows that they make an important contribution to prostate cancer risk prediction...
  50. pmc Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis
    Bora Gurel
    Department of Pathology, The Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA
    Mod Pathol 21:1156-67. 2008
    ....
  51. pmc Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy
    Richard A Schwarz
    Department of Bioengineering, Rice University, Houston, Texas, USA
    Cancer 115:1669-79. 2009
    ..In this study, we evaluated the diagnostic performance of a depth-sensitive optical spectroscopy (DSOS) system for distinguishing dysplasia and carcinoma from non-neoplastic oral mucosa...
  52. ncbi Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3
    Stefano Farioli-Vecchioli
    Institute of Neurobiology and Molecular Medicine, Consiglio Nazionale Ricerche, Via Fosso di Fiorano 64, 00143, Rome, Italy
    FASEB J 21:2215-25. 2007
    ..As a whole, this indicates that PC3 may prevent medulloblastoma development by controlling cell cycle and promoting differentiation of GCPs...
  53. pmc A multi-center prospective cohort study of benign breast disease and risk of subsequent breast cancer
    Geoffrey C Kabat
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, 10461, USA
    Cancer Causes Control 21:821-8. 2010
    ....
  54. pmc Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer
    Kieran Brune
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 30:1067-76. 2006
    ..The multifocal nature of familial pancreatic neoplasia suggests that surveillance of these patients is warranted after partial pancreatectomy...
  55. ncbi Aristaless-like homeobox-4 gene methylation is a potential marker for colorectal adenocarcinomas
    Matthias P A Ebert
    Epigenomics Inc, Seattle, Washington Fred Hutchinson Cancer Center, Seattle, Washington, USA
    Gastroenterology 131:1418-30. 2006
    ....
  56. pmc DNA promoter hypermethylation of p16 and APC predicts neoplastic progression in Barrett's esophagus
    Jean S Wang
    Department of Medicine Gastroenterology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Gastroenterol 104:2153-60. 2009
    ..We determined whether DNA promoter hypermethylation of genes frequently methylated in esophageal adenocarcinoma (p16 and APC) could be used as predictors of progression in BE...
  57. pmc Multiple head and neck tumors frequently originate from a single preneoplastic lesion
    Maarten P Tabor
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Am J Pathol 161:1051-60. 2002
    ....
  58. ncbi Polymorphisms of death pathway genes FAS and FASL and risk of premalignant gastric lesions
    Ping I Hsu
    Division of Gastroenterology and General Medicine, Department of Medicine, Kaohsiung Veterans General Hospital and National Yang Ming University, Kaohsiung, Taiwan, R O C
    Anticancer Res 28:97-103. 2008
    ..The aim of this study was to investigate whether functional polymorphisms of death pathway genes (FAS and FASL) are associated with the development of gastric atrophy and intestinal metaplasia...
  59. ncbi Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN
    Jens T Siveke
    Department of Internal Medicine, Technical University of Munich, D 81675 Munich, Germany
    Cancer Cell 12:266-79. 2007
    ..In conclusion, Egfr signaling in synergy with oncogenic Kras may be a prerequisite for IPMN development and progression to pancreatic cancer...
  60. ncbi Genetic polymorphism of cytochrome P4501A1 and susceptibility to oral squamous cell carcinoma and oral precancer lesions associated with smoking/betel use
    Shou Yen Kao
    Department of Dentistry, Oral and Maxillofacial Surgery, Taipei Veterans General Hospital, Taiwan, ROC
    J Oral Pathol Med 31:505-11. 2002
    ..It is also important to evaluate the association between CYP1A1 polymorphisms and susceptibility of oral precancerous lesion (OPL) to confirm the findings in OSCC cases...
  61. ncbi NAD(P)H and collagen as in vivo quantitative fluorescent biomarkers of epithelial precancerous changes
    Irene Georgakoudi
    G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Cancer Res 62:682-7. 2002
    ....
  62. ncbi Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo
    Kip A West
    Cancer Therapeutics Branch, Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 64:446-51. 2004
    ....
  63. ncbi Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship
    David W Kindelberger
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Surg Pathol 31:161-9. 2007
    ....
  64. ncbi Tumour biology: senescence in premalignant tumours
    Manuel Collado
    Spanish National Cancer Centre CNIO, Madrid 28029, Spain
    Nature 436:642. 2005
    ..Senescence is therefore a defining feature of premalignant tumours that could prove valuable in the diagnosis and prognosis of cancer...
  65. pmc Azoxymethane-induced rat aberrant crypt foci: relevance in studying chemoprevention of colon cancer
    Jayadev Raju
    Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch, Health Canada, C218 Banting Building, Postal Locator 2202D, Ottawa, K1A 0L2, Ontario, Canada
    World J Gastroenterol 14:6632-5. 2008
    ..The role of the dynamics and biological heterogeneity of ACF is critical in understanding them as biomarkers in chemoprevention studies...
  66. ncbi Cancer: crime and punishment
    Norman E Sharpless
    Nature 436:636-7. 2005
  67. ncbi Diagnosis of specialized intestinal metaplasia by optical coherence tomography
    J M Poneros
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 120:7-12. 2001
    ..CONCLUSIONS: OCT is highly sensitive and specific for SIM and may aid in the diagnosis and surveillance of this preneoplastic lesion...
  68. ncbi Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans
    Daniel W Rosenberg
    Colon Cancer Prevention Program, Neag Comprehensive Cancer Center, and Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Cancer Res 67:3551-4. 2007
    ....
  69. ncbi Epidemiology of cancer from the oral cavity and oropharynx
    Rene Lambert
    Screening Group, International Agency for Research on Cancer, Lyon, France
    Eur J Gastroenterol Hepatol 23:633-41. 2011
    ..In contrast, an increased incidence occurs in the world at tumor sites related to human papilloma virus infection in relation to changes in sexual habits...
  70. ncbi Ki-67 and ProExC are useful immunohistochemical markers in esophageal squamous intraepithelial neoplasia
    Wen Chuang Wang
    Department of Pathology, Chia Yi Christian Hospital, Chia Yi City, 60002 Taiwan
    Hum Pathol 42:1430-7. 2011
    ..This study demonstrates that both Ki-67 and ProExC can be used as an adjunct tool for diagnosing difficult cases of esophageal squamous intraepithelial neoplasia...
  71. ncbi Serum fucosylation changes in oral cancer and oral precancerous conditions: alpha-L-fucosidase as a marker
    Manisha Shah
    Biochemistry Research Division, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India
    Cancer 113:336-46. 2008
    ..The objective of the current study was to investigate the clinical usefulness of serum fucose, fucosylated glycoproteins (fucoproteins), fucosyltransferase (FucT), and alpha-L-fucosidase in oral carcinoma...
  72. pmc Exciting new advances in oral cancer diagnosis: avenues to early detection
    Ravi Mehrotra
    Department of Pathology, Moti Lal Nehru Medical College, Lowther Road Allahabad, 211001, India
    Head Neck Oncol 3:33. 2011
    ..This state of the art review critically examines these tests and assesses their value in identifying oral squamous cell carcinoma and its precursor lesions...
  73. ncbi Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma
    Trudy G Oliver
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 132:2425-39. 2005
    ..The identification and molecular characterization of pre-neoplastic cells provides insight into the early steps in medulloblastoma formation, and may yield important markers for early detection and therapy of this disease...
  74. ncbi Oral cancer and oral erythroplakia: an update and implication for clinicians
    A Villa
    Department of Medicine, Surgery and Dentistry, University of Milan, Milan, Italy
    Aust Dent J 56:253-6. 2011
    ..Early detection and diagnosis is still the key to survival rates. Dentists and physicians may play an important role in the detection of premalignant lesions and therefore improve patients' outcome...
  75. pmc Genome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome
    Eri Arai
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Carcinogenesis 30:214-21. 2009
    ..DNA methylation alterations in the precancerous stage may generate more malignant clear cell RCCs and determine patient outcome...
  76. pmc In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis
    G J Nuovo
    MGN Medical Research Laboratory, Setauket, NY 11733, USA
    Proc Natl Acad Sci U S A 96:12754-9. 1999
    ..These studies demonstrate that MSP-ISH is a powerful approach for studying the dynamics of aberrant methylation of critical tumor suppressor genes during tumor evolution...
  77. pmc Acute pancreatitis accelerates initiation and progression to pancreatic cancer in mice expressing oncogenic Kras in the nestin cell lineage
    CATHERINE CARRIERE
    Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire, United States of America
    PLoS ONE 6:e27725. 2011
    ..Thus, these data show that oncogenic Kras-driven PanIN originating in a non-ductal compartment can rapidly progress to PDAC when subjected to a brief inflammatory insult...
  78. ncbi Suppression of azoxymethane-induced colonic preneoplastic lesions in rats by 1-methyltryptophan, an inhibitor of indoleamine 2,3-dioxygenase
    Kengo Ogawa
    First Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Sci 103:951-8. 2012
    ....
  79. ncbi Utility of toluidine blue as a diagnostic adjunct in the detection of potentially malignant disorders of the oral cavity--a clinical and histological assessment
    Kh Awan
    Oral Medicine and Head and Neck Pathology, Department of Clinical and Diagnostic Sciences, King s College London Dental Institute, London, UK
    Oral Dis 18:728-33. 2012
    ..The value of chairside adjunctive tests in the detection of oral potentially malignant disorders (OPMDs) remains uncertain...
  80. pmc Human papillomavirus (HPV) genotypes in women with cervical precancer and cancer at Kaiser Permanente Northern California
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 20:946-53. 2011
    ..Here, we present the HPV genotypes found in first ∼500 cases of cervical intraepithelial neoplasia grade 3 (CIN3) or more severe disease (CIN3+) diagnosed at the study baseline...
  81. ncbi Carcinogenesis of Helicobacter pylori
    Pelayo Correa
    Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Gastroenterology 133:659-72. 2007
    ....
  82. pmc Pancreatic duct glands are distinct ductal compartments that react to chronic injury and mediate Shh-induced metaplasia
    Oliver Strobel
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Gastroenterology 138:1166-77. 2010
    ..A majority of PanIN are thought to arise from ducts. We identified a novel ductal compartment that is gathered in gland-like outpouches (pancreatic duct glands [PDG]) of major ducts and characterized its role in injury and metaplasia...
  83. ncbi Pathophysiology, etiologic factors, and clinical management of oral lichen planus, part I: facts and controversies
    David Farhi
    Department of Dermatology and Venereology, Hopital Cochin, APHP, Université Descartes Paris 5, Pavillon Tarnier, 75006 Paris, France
    Clin Dermatol 28:100-8. 2010
    ..The first-line pharmacologic treatment relies on topical steroids. Systemic steroids should be limited to the short-term cure of severe refractory OLP. Life-long clinical follow-up, at least annually, is fundamental...
  84. ncbi Sessile serrated adenoma with early neoplastic progression: a clinicopathologic and molecular study
    Kohei Fujita
    Department of Anatomic Pathology, Kyushu University, Fukuoka, Japan
    Am J Surg Pathol 35:295-304. 2011
    ..In addition, our histologic observations suggest a possible close association between SSAN and mucinous adenocarcinoma...
  85. ncbi Potentially malignant disorders of the oral and oropharyngeal mucosa; present concepts of management
    Isaac van der Waal
    Department of Oral and Maxillofacial Surgery Pathology, VU University Medical Center Academic Centre for Dentistry Amsterdam, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Oral Oncol 46:423-5. 2010
    ..At present, oral lichen planus is more or less accepted as being a potentially malignant disorder. There are no means to prevent such event. The efficacy of follow-up of oral lichen planus is questionable...
  86. pmc Diagnostic aids for detection of oral precancerous conditions
    Diana V Messadi
    University of California, Los Angeles, CA, USA
    Int J Oral Sci 5:59-65. 2013
    ..In addition, the most common non-invasive oral cancer devices that can aid the general practitioners in early diagnosis are also discussed. ..
  87. ncbi Helicobacter pylori cytotoxin-associated genotype and gastric precancerous lesions
    Martyn Plummer
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    J Natl Cancer Inst 99:1328-34. 2007
    ..pylori genes to the severity and progression of precancerous lesions is not well defined...
  88. ncbi CIN2 is a much less reproducible and less valid diagnosis than CIN3: results from a histological review of population-based cervical samples
    Joseph D Carreon
    Division of Cancer Epidemiology and Genetics, The National Cancer Institute, National Institutes of Health, Department of Health and Human Services Rockville, Maryland 20852, USA
    Int J Gynecol Pathol 26:441-6. 2007
    ..The CIN3 is a substantially more reproducible diagnosis that can be validated more frequently with HPV tests and cytological interpretations than CIN2...
  89. ncbi Malignant transformation of oral epithelial dysplasia: clinicopathological risk factors and outcome analysis in a retrospective cohort of 138 cases
    Wei Liu
    Department of Oral Mucosal Diseases, Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, China
    Histopathology 59:733-40. 2011
    ....
  90. ncbi Pitavastatin inhibits azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice
    Yoichi Yasuda
    Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Sci 101:1701-7. 2010
    ..Therefore, some types of statins, including pitavastatin, may be a useful chemoprevention modality for colon cancer in obese individuals...
  91. ncbi Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues
    Michaela Aichler
    Institute of Pathology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    J Pathol 226:723-34. 2012
    ..In conclusion, PDAC development in Kras(G12D/+); Ptf1a-Cre(ex1/+) mice starts from ADM and a similar process might also take place in patients with a strong family history of PDAC...
  92. pmc New insights into the pathogenesis of serous ovarian cancer and its clinical impact
    Keren Levanon
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 26:5284-93. 2008
    ..With the rise of the fallopian tube secretory epithelial cell as a cell of origin for high-grade pelvic serous carcinomas, the need to develop tools and model systems to characterize the biology and physiology of this cell is recognized...
  93. ncbi Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis
    Karwan A Moutasim
    Faculty of Medicine, Southampton Cancer Research UK Centre, University of Southampton, Southampton, UK
    J Pathol 223:366-77. 2011
    ..Over 80% of OSF-related oral cancers examined had moderate/high αvβ6 expression. These data suggest that the pathogenesis of OSF may be epithelial-driven and involve arecoline-dependent up-regulation of αvβ6 integrin...
  94. pmc Carbohydrate antigens in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsy
    Susan L Deutscher
    University of Missouri, Department of Biochemistry, One Hospital Drive, Columbia, MO 65212, USA
    BMC Cancer 10:519. 2010
    ....
  95. ncbi Magnifying endoscopy combined with narrow-band imaging for differential diagnosis of superficial depressed gastric lesions
    M Kaise
    Department of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan
    Endoscopy 41:310-5. 2009
    ..The aim of our study was to evaluate ME-NBI criteria for cancer diagnosis in superficial depressed gastric lesions in comparison to conventional white light endoscopy (WLE)...
  96. ncbi Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions
    Wei Cheng You
    Peking University School of Oncology, Beijing Cancer Hospital and Beijing Institute for Cancer Research, Beijing, China
    J Natl Cancer Inst 98:974-83. 2006
    ..We conducted a randomized trial to test the effects of one-time H. pylori treatment and long-term vitamin or garlic supplements in reducing the prevalence of advanced precancerous gastric lesions...
  97. pmc Comparison of increased aromatase versus ERα in the generation of mammary hyperplasia and cancer
    Edgar S Diaz-Cruz
    Departments of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia
    Cancer Res 71:5477-87. 2011
    ....
  98. pmc Factors predicting progression of gastric intestinal metaplasia: results of a randomised trial on Helicobacter pylori eradication
    W K Leung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, Hong Kong
    Gut 53:1244-9. 2004
    ..Gastric intestinal metaplasia (IM) is generally considered to be a precancerous lesion in the gastric carcinogenesis cascade. This study identified the risk factors associated with progression of IM in a randomised control study...
  99. pmc Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
    Nils Habbe
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:18913-8. 2008
    ....
  100. ncbi Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms are not associated with premalignant gastric conditions: a combined haplotype analysis
    Limas Kupcinskas
    Department of Gastroenterology, Kaunas University of Medicine, Kaunas, Lithuania
    Eur J Gastroenterol Hepatol 22:1189-95. 2010
    ..Here, IL1B and IL1RN polymorphisms were analyzed as genotypes and haplotypes in relation to the presence of atrophic gastritis (AG) and intestinal metaplasia in the stomach...
  101. pmc Epithelial membrane protein-2 expression is an early predictor of endometrial cancer development
    Omar Habeeb
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Cancer 116:4718-26. 2010
    ..Here the authors validate the expression of EMP2 in EC, and further examine whether EMP2 expression within preneoplastic lesions is an early prognostic biomarker for EC development...

Research Grants65

  1. N-3 Fatty Acid-Induced Akt Suppression: Chemoprevention for Pancreatic Neoplasia
    PAUL JOSEPH GRIPPO; Fiscal Year: 2013
    ..Hence, novel approaches to fighting these precancerous conditions must evolve, including chemoprevention, where dietary intake of fats and inhibition of key signaling ..
  2. Selenium Colorectal Cancer Chemoprevention Trials
    PATRICIA ANN THOMPSON; Fiscal Year: 2013
    ..In secondary analyses, we will investigate whether or not baseline Se levels, genetic background, and/or use of low-dose aspirin modify Se effects on CRA occurrence or risk for T2D. ..
  3. TAS::75 0849::TAS CONTINUATION OF FOLLOW-UP OF DES-EXPOSED COHORTS
    Linda Titus Ernstoff; Fiscal Year: 2010
    ..abstract_text> ..
  4. TAS::75 0849::TAS CONTINUATION OF FOLLOW-UP OF DES-EXPOSED COHORT
    ARTHUR HERBST; Fiscal Year: 2010
    ..abstract_text> ..
  5. Glycans in Hepatocellular Carcinoma
    Radoslav Goldman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Early detection of cancer and precancerous conditions improves patient survival...
  6. EARLY DETECTION OF URINARY BLADDER CANCER
    Bogdan Czerniak; Fiscal Year: 2009
    ..e. the forerunner genes and Aurora-A with its partners, appear to be universally involved in human carcinogenesis the completion of this project will have major relevance for early detection of other common human cancers. ..
  7. H PYLORI AND GASTRIC PRENEOPLASTIC LESIONS
    Julie Parsonnet; Fiscal Year: 1999
    ..pylori therapy reverses preneoplastic lesions, however, could provide a foundation for gastric cancer screening and prevention trials as well as enhance understanding of preneoplasia and inflammation- related carcinogenesis. ..
  8. Depth-Resolved Imaging of Alterations in Mucosal Microcirculation
    SARAH K RUDERMAN; Fiscal Year: 2013
    ..lead to an in vivo imaging application that would allow for accurately detecting structural changes of precancerous conditions from the endoscopically-normal tissue during a colonoscopy...
  9. Microarrays of Intermediate Endpoints of Gastric Cancer
    Julie Parsonnet; Fiscal Year: 2004
    ..abstract_text> ..
  10. THE RELATIONSHIP BETWEEN BLOOD AND TISSUE MICRONUTRIENT
    YEI MEI PENG; Fiscal Year: 1993
    ..target tissue concentration of the micronutrient may be critical for the prevention of cancer and/or precancerous conditions. In order to define the role of micronutrients in cancer prevention, it is, therefore, important to study ..
  11. Raman Probe for Bronchial Premalignant Lesions
    Stephen Fulghum; Fiscal Year: 2006
    ..with a fiberoptic probe, for use with a bronchoscope, for characterizing bronchial tissue with respect to precancerous conditions. The system will be especially effective with a new generation of bronchoscopes that have their screening ..
  12. PARADIGM OF MULTISTEP URINARY BLADDER CARCINOGENESIS
    Bogdan Czerniak; Fiscal Year: 2006
    ....
  13. Proteomic Analysis of Serum in Liver Cancer
    Radoslav Goldman; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Early detection of cancer and precancerous conditions improves patient survival. This study will identify a set of peptides and proteins (P/P) in serum associated with hepatocellular carcinoma (HCC)...
  14. Optimization of enrichment for MALDI TOF/TOF identification of cancer biomarkers
    Radoslav Goldman; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Early detection of cancer and precancerous conditions improves patient survival...
  15. The Perception of Cancer Risk in Patients with Barrett's Esophagus
    Nicholas Shaheen; Fiscal Year: 2007
    ..The resultant study application will assess health-related quality of life, health-related anxiety and healthcare utilization as outcomes. [unreadable] [unreadable]..
  16. Epidemiologic Case-control Study of Barrett's Esophagus
    Nicholas Shaheen; Fiscal Year: 2005
    ..Finally, by comparing subjects with Barrett's to controls with reflux, and controlling for severs of reflux, the impact of a Barrett's diagnosis on quality of life and psychological stress may be seen. ..
  17. Biomarkers in Phototherapy of Barrett's Esophagus
    Kenneth K Wang; Fiscal Year: 2010
    ..These studies will provide an improved understanding regarding the response of Barrett's esophagus to ablation therapy. ..
  18. Novel Method of Surveillance in Barrett's Esophagus
    Kenneth Wang; Fiscal Year: 2008
    ..This is an innovative method by which a physician can diagnose hidden areas of cancer within patients who are at a high risk of developing esophageal cancer. [unreadable] [unreadable] [unreadable]..
  19. A NOVEL TECHNIQUE FOR SCREENING BARRETT'S ESOSPHAGUS
    Kenneth Wang; Fiscal Year: 2003
    ..The development of a screening device for Barrett's esophagus that could be operated by paramedical personnel would enable large-scale low cost screening to identify patients at risk for esophageal cancer. ..
  20. Endoscopic Therapy of Early Cancer in Barretts Esophagus
    Kenneth Wang; Fiscal Year: 2009
    ..Diagnostic and therapeutic techniques developed in this study can be applied to other gastrointestinal tumors. ..
  21. P53 in BBD and Breast Cancer Risk: A Multicenter Cohort
    Thomas Rohan; Fiscal Year: 2006
    ..Furthermore, establishment of our international, multi-disciplinary group will create a unique forum in which to undertake not only this study but also further investigations of the molecular pathogenesis of breast cancer. ..
  22. MOLECULAR DETERMINANTS OF ANGIOGENSIS IN ORAL CANCER
    Mark Lingen; Fiscal Year: 2005
    ....
  23. Molecular Profiling of Premalignant Oral Lesions
    Mark Lingen; Fiscal Year: 2008
    ..This molecular analysis may also greatly improve diagnostic prediction compared to the cellular pattern recognition currently used by pathologists. [unreadable] [unreadable]..
  24. Automated Tissue Arrayer
    Mark Lingen; Fiscal Year: 2004
    ..An already established Internal Advisory Committee will oversee an equitable and appropriate use by a broad disciplinary group of scientists while giving priority to NIH-supported groups. ..
  25. Oral Cancer, Chemoprevention, and Anti-Angiogenesis
    Mark Lingen; Fiscal Year: 2009
    ..abstract_text> ..
  26. Colon and liver anticarcinogenicity by acetaminophen
    Gary Williams; Fiscal Year: 2004
    ..In addition, these experiments will provide support for the epidemiological observations of reduced cancer risk associated with the use of APAP. ..
  27. Biomarkers and Chemoprevention of Endometrial Cancer
    George Mutter; Fiscal Year: 2006
    ..If successful, we will be able to rapidly implement a rational and effective strategy for early detection and chemoprevention of endometrial carcinoma. ..
  28. Pathogenesis of Ovarian Serous Borderline Tumors
    Robert J Kurman; Fiscal Year: 2010
    ..This will refine diagnostic and prognostic markers of advanced stage tumors. These results will be expected to have a significant impact on the clinical management of patients with this disease. ..
  29. Epidemiology and Incidence of Barrett's Esophagus
    DOUGLAS ALLEN CORLEY; Fiscal Year: 2010
    ..The proposed study explores how hormones associated with body fat may change the way the body heals after an injury, and increase the risk of cells developing precancerous changes. ..
  30. Pixel-accurate oncologic therapy using a scanning fiber endoscope
    Eric J Seibel; Fiscal Year: 2010
    ..abstract_text> ..
  31. MOLECULAR MODELING OF DIAGNOSIS AND PROGNOSIS IN HNSCC
    Maria Worsham; Fiscal Year: 2009
    ..abstract_text> ..
  32. Interdisciplinary researchers to address biomedical optics challenges, BIOMED 06
    Judith Mourant; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  33. MOLECULAR EPIDEMIOLOGY OF PERSISTENT HPV INFECTION
    Eduardo Franco; Fiscal Year: 2003
    ..abstract_text> ..
  34. HELICOBACTER INFECTION AND GROWTH OF CHILDREN
    Pelayo Correa; Fiscal Year: 2001
    ..pylori infection and growth retardation, essential information for evaluating the effects of H. pylori infection on children's health and targeting appropriate preventive strategies. ..
  35. BENIGN BREAST DISEASE--MOLECULAR DIFFERENTIATION OF RISK
    Maria Worsham; Fiscal Year: 2001
    ....
  36. Predictors of Progression in Barret's Esophagus
    Brian Reid; Fiscal Year: 2001
    ..Successful completion of these aims will provide a scientific basis for i) prevention trials using candidate interventions and validated intermediate endpoints, and ii) a more rational surveillance strategy for BE. ..
  37. P53 AND DNA PLOIDY IN BARRETT'S METAPLASIA
    Mamoun Younes; Fiscal Year: 2005
    ..A cost analysis will be then performed to determine whether a molecular based surveillance program would be more cost-effective than current program which is based on morphologic grading of dysplasia. ..
  38. Hormonal modulation of latent endometrial precancers
    George Mutter; Fiscal Year: 2008
    ..If our hypothesis is confirmed, this project will establish biomarker-detectable preclinical disease as a surrogate marker for risk surveillance, and a potential target for cancer preventative therapies. ..
  39. Randomized Trial of EUS Neurolysis in Pancreas Cancer
    Michael Wallace; Fiscal Year: 2006
    ..The primary outcome will be a reduction in pain at 1 month. Secondary outcomes will include the durability of pain control, quality of life, narcotic use and narcotic side effects. [unreadable] [unreadable]..
  40. Image-guided catheter biopsy of peripheral lung cancer
    Eric Seibel; Fiscal Year: 2005
    ..abstract_text> ..
  41. CatheterScope for Intraluminal Image of Early.Neoplasia
    Eric Seibel; Fiscal Year: 2006
    ..abstract_text> ..
  42. RAMAN SPECTROSCOPY FOR CANCER DIAGNOSIS AND MONITORING
    Judith Mourant; Fiscal Year: 2005
    ..We will focus on developing Raman spectroscopy for detection of precancerous conditions in patients with Barrett's esophagus...
  43. Dectection of occult mediastinal lymph node mestastases
    Michael Wallace; Fiscal Year: 2007
    ..In the R33 component of the grant application these criteria will be prospectively evaluated and correlated with clinical outcome in a second, larger cohort of patients. ..
  44. The Molecular Basis of Juvenile Polyposis
    James Howe; Fiscal Year: 2005
    ..These studies will also benefit JP patients by improving presymptomatic genetic testing, and identification of new therapeutic targets for polyp regression and cancer prevention in JP. ..
  45. Testing of Novel Apoptotic Agents in Prostate Cancer
    Ching Shih Chen; Fiscal Year: 2002
    ..Together, these animal-- model studies will validate that the in vitro apoptosis-inducing effect of these compounds is relevant for tumor growth inhibition in vivo. ..
  46. DIFFERENTIATION OF BLOOD STEM CELLS INTO LIVER CELLS
    Stewart Sell; Fiscal Year: 2005
    ..If this project is successful, it would overcome a major hurdle in the possible use of hepatic stem cells for treatment of liver failure or ex vivo gene therapy. ..
  47. Clinical Significance of Apoptosis in Colon Cancer
    Frank Sinicrope; Fiscal Year: 2006
    ..abstract_text> ..
  48. Prophytactic surgery in carriers of BRCA 1/2 mutations
    Timothy R Rebbeck; Fiscal Year: 2010
    ..These studies will motivate future studies of BRCA1/2-associated breast tumor biology, prevention, and treatment. ..
  49. Colorectal Screening Capacity Building Conference
    David Alberts; Fiscal Year: 2003
    ..Continued capacity building and future collaboration will also be woven into this conference to serve as a stone to build upon in the future. ..
  50. CHROMOSOME ALTERATIONS IN BARRETT'S ESOPHAGUS
    THOMAS PAULSON; Fiscal Year: 2005
    ..The results from these analyses will be of interest to both clinical and basic researchers in studying EA and other cancers. ..
  51. Potential for HIV transmission in relationships of drug-using women in Russia
    Linda Niccolai; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  52. Workshop On Experimental Models from Bursa of Fabricius
    Paul Neiman; Fiscal Year: 2002
    ..This workshop will serve to stimulate further development and application, and to educate interested young scientists to the opportunities presented. ..
  53. Activated Immune Parameters Associated with HIV & Aging
    Bruce Shiramizu; Fiscal Year: 2004
    ....
  54. HEPTOCYTE PROLIFERATION AND AFLATOXIN METABOLISM
    Stewart Sell; Fiscal Year: 2004
    ..the effect Of HBV associated injury and AFB I hepatocarcinogensis in these mice. In Specific Aim 3, the effect of HBV associated injury and AFB1 hepatocarcinogenesis in these mice will be examined. ..
  55. TARGETED DRUG THERAPY FOR LGL LEUKEMIA
    Pearlie K Epling Burnette; Fiscal Year: 2008
    ..Results of these studies should identify important molecular targets for drug development in bone marrow failure syndromes. ..
  56. Colorectal Cancer Screening: Fecal Blood vs DNA
    David Ahlquist; Fiscal Year: 2004
    ..If the DNA-based test proves to have greater screening accuracy than fecal blood testing, this could translate into more effective cancer control and more efficient use of our limited health care resources. ..
  57. Screening for colortectal cancer in an Asian Community Center
    David Lieberman; Fiscal Year: 2008
    ..This is a new paradigm for screening, which takes advantage of the trust and cultural awareness that exists at the community center and does not rely on the primary care provider. [unreadable] [unreadable] [unreadable] [unreadable]..
  58. Phase II Trial of Thalidomide in Primary Amyloidosis
    Angela Dispenzieri; Fiscal Year: 2002
    ..The ultimate goal of the proposed studies is to improve the prognosis of patient with this fatal disease. ..
  59. CORI: Consortium Expansion and Database Enhancement
    David Lieberman; Fiscal Year: 2004
    ....
  60. Chemoprevention of Head and Neck Cancer with ZD1839 and Celecoxib
    Dong Shin; Fiscal Year: 2008
    ..Biomarker changes will be correlated with cancer incidence by statistical analyses. We will also determine whether such biomarker changes can serve as intermediate endpoint(s) in this chemopreventive trial. ..