dextrorphan

Summary

Summary: Dextro form of levorphanol. It acts as a noncompetitive NMDA receptor antagonist, among other effects, and has been proposed as a neuroprotective agent. It is also a metabolite of DEXTROMETHORPHAN.

Top Publications

  1. ncbi CYP2D6 phenotyping with dextromethorphan
    Anna Wojtczak
    Department of Pharmacogenetics, Medical University of Łódź, Muszynskiego 1, PL 90 151 Łódź, Poland
    Pharmacol Rep 59:734-8. 2007
  2. ncbi Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan
    Y C Chou
    Institute of Pharmacology, National Yang Ming University, 155 Li nung Street, Section 2, Taipei 112, Taiwan
    Brain Res 821:516-9. 1999
  3. ncbi Dextromethorphan to dextrorphan urinary metabolic ratio does not reflect dextromethorphan oral clearance
    Silvana Borges
    Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Drug Metab Dispos 33:1052-5. 2005
  4. ncbi Metabolism to dextrorphan is not essential for dextromethorphan's anticonvulsant activity against kainate in mice
    Hyoung Chun Kim
    Neurotoxicology Program, Department of Pharmacy, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon 200 701, South Korea
    Life Sci 72:769-83. 2003
  5. ncbi An extension of hypotheses regarding rapid-acting, treatment-refractory, and conventional antidepressant activity of dextromethorphan and dextrorphan
    Edward C Lauterbach
    Department of Psychiatry and Behavioral Sciences, Mercer University School of Medicine, 1550 College Street, Macon, GA 31201, United States
    Med Hypotheses 78:693-702. 2012
  6. ncbi Serum dextromethorphan/dextrorphan metabolic ratio for CYP2D6 phenotyping in clinical practice
    J Jurica
    Department of Pharmacology, Faculty of Medicine, Experimental and Applied Neuropsychopharmacology Research Group, Central European Institute of Technology CEITEC, Masaryk University, Brno, Czech Republic
    J Clin Pharm Ther 37:486-90. 2012
  7. ncbi Isobolographic analysis of epinephrine with bupivacaine, dextromethorphan, 3-methoxymorphinan, or dextrorphan on infiltrative anesthesia in rats: dose-response studies
    Yu Wen Chen
    Department of Physical Therapy, China Medical University, Taichung, Taiwan
    Reg Anesth Pain Med 33:115-21. 2008
  8. pmc Comparative effects of dextromethorphan and dextrorphan on nicotine discrimination in rats
    M Jerry Wright
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 23298 0613 USA
    Pharmacol Biochem Behav 85:507-13. 2006
  9. ncbi N-methyl-D-aspartate (NMDA) antagonists--S(+)-ketamine, dextrorphan, and dextromethorphan--act as calcium antagonists on bovine cerebral arteries
    Ihab R Kamel
    Department of Anesthesiology, Temple University Hospital, Philadelphia, PA 19140, USA
    J Neurosurg Anesthesiol 20:241-8. 2008
  10. ncbi Comparative effects of dextromethorphan and dextrorphan on morphine, methamphetamine, and nicotine self-administration in rats
    S D Glick
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 422:87-90. 2001

Research Grants

  1. Exogenous and Endogenous Biomarkers of CYP2D6 Variability in Pediatrics
    YVONNE SARAH LIN; Fiscal Year: 2013
  2. DEXTROROTATORY OPIOIDS AS PROBES FOR PCP RECEPTORS
    Thomas Murray; Fiscal Year: 1999
  3. PK-PD Models: The Role of Metabolites in Drug Action
    Howard Hendrickson; Fiscal Year: 2004
  4. CYTOCHROME P450 ACTIVITY IN THE FIRST YEAR OF LIFE
    JAMES LEEDER; Fiscal Year: 1999
  5. Ginkgo biloba for ECT-induced Memory Deficits
    JOHN MARKOWITZ; Fiscal Year: 2003
  6. Screening Herbs for Drug Interactions
    JOHN MARKOWITZ; Fiscal Year: 2002
  7. P-Glycoprotein and Disposition of Psychostimulants
    JOHN MARKOWITZ; Fiscal Year: 2005
  8. Evaluating Trichophyton tonsurans Carriage and Infection
    Susan Abdel Rahman; Fiscal Year: 2006
  9. FUNGAL PROTEIN/GLYCOPROTEIN EXPRESSION IN TINEA CAPITIS
    Susan Abdel Rahman; Fiscal Year: 2003
  10. BEHAVIORAL PHARMACOLOGY OF NARCOTIC ANTAGONISTS
    STEPHEN HOLTZMAN; Fiscal Year: 2002

Detail Information

Publications204 found, 100 shown here

  1. ncbi CYP2D6 phenotyping with dextromethorphan
    Anna Wojtczak
    Department of Pharmacogenetics, Medical University of Łódź, Muszynskiego 1, PL 90 151 Łódź, Poland
    Pharmacol Rep 59:734-8. 2007
    ..DM (40 mg) was given orally to healthy adults and 10-h urine samples were collected. DM and the metabolite dextrorphan (DX) were analyzed by the HPLC method...
  2. ncbi Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan
    Y C Chou
    Institute of Pharmacology, National Yang Ming University, 155 Li nung Street, Section 2, Taipei 112, Taiwan
    Brain Res 821:516-9. 1999
    ..DM is largely O-demethylated into the phencyclidine (PCP)-like compound dextrorphan (DR), which may limit its therapeutic use by producing PCP-like adverse effects, such as hyperlocomotion...
  3. ncbi Dextromethorphan to dextrorphan urinary metabolic ratio does not reflect dextromethorphan oral clearance
    Silvana Borges
    Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Drug Metab Dispos 33:1052-5. 2005
    ..Blood and urine samples were collected for 72 h. Dextromethorphan and dextrorphan were determined in urine by high-performance liquid chromatography with fluorescence detection and in serum by ..
  4. ncbi Metabolism to dextrorphan is not essential for dextromethorphan's anticonvulsant activity against kainate in mice
    Hyoung Chun Kim
    Neurotoxicology Program, Department of Pharmacy, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon 200 701, South Korea
    Life Sci 72:769-83. 2003
    The effects of dextromethorphan (DM), and its major metabolite dextrorphan (DX) on kainic acid-induced seizures in mice were examined. Intracerebroventricular DM or DX (5 or 10 microg/0...
  5. ncbi An extension of hypotheses regarding rapid-acting, treatment-refractory, and conventional antidepressant activity of dextromethorphan and dextrorphan
    Edward C Lauterbach
    Department of Psychiatry and Behavioral Sciences, Mercer University School of Medicine, 1550 College Street, Macon, GA 31201, United States
    Med Hypotheses 78:693-702. 2012
    It was previously hypothesized that dextromethorphan (DM) and dextrorphan (DX) may possess antidepressant properties, including rapid and conventional onsets of action and utility in treatment-refractory depression, based on ..
  6. ncbi Serum dextromethorphan/dextrorphan metabolic ratio for CYP2D6 phenotyping in clinical practice
    J Jurica
    Department of Pharmacology, Faculty of Medicine, Experimental and Applied Neuropsychopharmacology Research Group, Central European Institute of Technology CEITEC, Masaryk University, Brno, Czech Republic
    J Clin Pharm Ther 37:486-90. 2012
    ..Dextromethorphan-to-dextrorphan metabolic ratio (MR(DEM/DOR)) is well established as a marker of CYP2D6 metabolizer status...
  7. ncbi Isobolographic analysis of epinephrine with bupivacaine, dextromethorphan, 3-methoxymorphinan, or dextrorphan on infiltrative anesthesia in rats: dose-response studies
    Yu Wen Chen
    Department of Physical Therapy, China Medical University, Taichung, Taiwan
    Reg Anesth Pain Med 33:115-21. 2008
    ..study were to establish the potencies of epinephrine, bupivacaine, dextromethorphan, 3-methoxymorphinan, and dextrorphan and evaluate interactions of epinephrine with bupivacaine, dextromethorphan, 3-methoxymorphinan, or dextrorphan ..
  8. pmc Comparative effects of dextromethorphan and dextrorphan on nicotine discrimination in rats
    M Jerry Wright
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 23298 0613 USA
    Pharmacol Biochem Behav 85:507-13. 2006
    While the role of dextrorphan and dextromethorphan as N-methyl-d-aspartate (NMDA) receptor antagonists has received considerable research attention, their effects on nicotinic acetylcholine receptors (nAChR) has been less well ..
  9. ncbi N-methyl-D-aspartate (NMDA) antagonists--S(+)-ketamine, dextrorphan, and dextromethorphan--act as calcium antagonists on bovine cerebral arteries
    Ihab R Kamel
    Department of Anesthesiology, Temple University Hospital, Philadelphia, PA 19140, USA
    J Neurosurg Anesthesiol 20:241-8. 2008
    ..study was to compare the direct effects of S(+)-ketamine, 2 other noncompetitive NMDA receptor antagonists (dextrorphan and dextromethorphan), and the calcium entry blocker nimodipine on the cerebral vasculature, using bovine ..
  10. ncbi Comparative effects of dextromethorphan and dextrorphan on morphine, methamphetamine, and nicotine self-administration in rats
    S D Glick
    Center for Neuropharmacology and Neuroscience, Albany Medical College MC 136, 47 New Scotland Avenue, Albany, NY 12208, USA
    Eur J Pharmacol 422:87-90. 2001
    The effects of dextromethorphan and its metabolite dextrorphan on morphine, methamphetamine and nicotine self-administration and on responding for a nondrug reinforcer (water) were assessed in rats...
  11. ncbi Delayed treatment with dextromethorphan and dextrorphan reduces cerebral damage after transient focal ischemia
    G K Steinberg
    Division of Neurosurgery, Stanford University School of Medicine, CA 94305
    Neurosci Lett 89:193-7. 1988
    The N-methyl-D-aspartate (NMDA) antagonists dextromethorphan (DM) and dextrorphan (DX) were found to reduce significantly neocortical severe ischemic neuronal damage (SIND) when administered in a delayed fashion after the ischemic insult...
  12. ncbi Lack of interaction of the NMDA receptor antagonists dextromethorphan and dextrorphan with P-glycoprotein
    M Kanaan
    Clinical Pharmacology and Toxicology and Multidisciplinary Pain Center, Department of Anesthesiology, Pharmacology and Intensive Care, Geneva University Hospitals, CH 1211 Geneva 14, Switzerland
    Curr Drug Metab 9:144-51. 2008
    ..DEM) seems to be mainly related to the unchanged drug rather than to its more potent metabolite dextrorphan (DOR)...
  13. ncbi A validated SIM GC/MS method for the simultaneous determination of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in biological matrices and its application to in vitro CYP2D6 and CYP3A4 inhibition study
    Marios Spanakis
    Department of Pharmacognosy, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
    Biomed Chromatogr 23:1131-7. 2009
    ..GC/MS method without derivatization for the simultaneous determination of dextromethorphan and its metabolites, dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan, in human plasma, urine and in vitro incubation matrix was developed ..
  14. ncbi Differential binding properties of [3H]dextrorphan and [3H]MK-801 in heterologously expressed NMDA receptors
    K T LePage
    Department of Physiology and Pharmacology, The University of Georgia, College of Veterinary Medicine, Athens, GA 30602, USA
    Neuropharmacology 49:1-16. 2005
    ..Similarly, the psychotomimetic effects of the dextrorotatory opioids, dextromethorphan and its metabolite dextrorphan, derive from their NMDAR antagonist actions...
  15. ncbi Systemic dextromethorphan and dextrorphan are less toxic in rats than bupivacaine at equianesthetic doses
    Yu Wen Chen
    Department of Physical Therapy, China Medical University, Taichung, Taiwan
    Can J Anaesth 58:55-61. 2011
    b>Dextrorphan, a major metabolite of dextromethorphan, produces the duration of spinal and cutaneous anesthesia similar to bupivacaine...
  16. ncbi Simultaneous determination of dextromethorphan, dextrorphan and doxylamine in human plasma by HPLC coupled to electrospray ionization tandem mass spectrometry: application to a pharmacokinetic study
    J L Donato
    ATCGen Biotechnology, Campinas, Sao Paulo, Brazil
    J Chromatogr B Analyt Technol Biomed Life Sci 899:46-56. 2012
    In the present study, a fast, sensitive and robust method to quantify dextromethorphan, dextrorphan and doxylamine in human plasma using deuterated internal standards (IS) is described...
  17. ncbi Semi-automated liquid--liquid back-extraction in a 96-well format to decrease sample preparation time for the determination of dextromethorphan and dextrorphan in human plasma
    Renee D Bolden
    Procter and Gamble Pharmaceuticals, 8700 Mason Montgomery Road, Mason, OH 45040, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 772:1-10. 2002
    ..preparation of dextromethorphan (DEX), an active ingredient in many over-the-counter cough formulations, and dextrorphan (DOR), an active metabolite of DEX, in human plasma...
  18. ncbi The spinal anaesthetic effect of dextromethorphan, dextrorphan, and 3-methoxymorphinan
    Yu Wen Chen
    Department of Medical Research, Chi Mei Medical Centre, Tainan, Taiwan
    Eur J Pharmacol 569:188-93. 2007
    ..Our aim was to evaluate whether dextromethorphan and its metabolites, dextrorphan and 3-methoxymorphinan, have a spinal anaesthetic effect...
  19. ncbi Inactivation of CYP2D6 by methylenedioxymethamphetamine in different recombinant expression systems
    Linh M Van
    University of Sheffield, Academic Unit of Clinical Pharmacology, University of Sheffield, Sheffield S10 2JF, UK
    Eur J Pharm Sci 32:8-16. 2007
    ..The formation of dextrorphan (DOR) from DEX was used as a specific marker of CYP2D6 activity...
  20. ncbi High-throughput biological sample analysis using on-line turbulent flow extraction combined with monolithic column liquid chromatography/tandem mass spectrometry
    Shaolian Zhou
    DMPK Bioanalytical Chemistry Department, Covance Laboratories Inc, Madison, WI 53704, USA
    Rapid Commun Mass Spectrom 19:2144-50. 2005
    ..peak shape, sensitivity, speed, and matrix effect were conducted with dextromethorphan and its metabolite dextrorphan as model compounds in human plasma matrix...
  21. ncbi Validation of a liquid chromatography-mass spectrometry method to assess the metabolism of dextromethorphan in rat everted gut sacs
    C Arellano
    Laboratoire de Cinétique des Xénobiotiques, UMR 181, Physiopathologie et Toxicologie Experimentale UPTE INRA ENVT, Faculte des sciences pharmaceutiques, 35 chemin des Maraichers, 31062 Toulouse, France
    J Chromatogr B Analyt Technol Biomed Life Sci 819:105-13. 2005
    ..1-2.5 microM (27.1 ng/mL-0.677 microg/mL) for dextromethorphan and 0.005-0.5 microM for dextrorphan and 3-methoxymorphinan (1.28 ng/mL-0.128 microg/mL) and 3-hydroxymorphinan (1.22 ng/mL-0.122 microg/mL)...
  22. ncbi Effect of ion suppression on judgment of enzyme inhibition and avoidance of error by utilizing a stable isotope-labeled probe substrate: example of CYP3A4 inhibition with [13C4,15N] labeled midazolam as a substrate
    Koichi Nakamura
    Drug Metabolism and Physicochemistry Research Laboratory, R and D Division, Daiichi Pharmaceutical Co, Ltd
    Drug Metab Pharmacokinet 22:113-8. 2007
    ..In this study, we have shown the ion suppression of 1'-hydroxymidazolam (analyte) and dextrorphan (IS) by erythromycin, as an example, which may cause over- or underestimation of CYP3A4 inhibition...
  23. ncbi On-line solid phase extraction using the Prospekt-2 coupled with a liquid chromatography/tandem mass spectrometer for the determination of dextromethorphan, dextrorphan and guaifenesin in human plasma
    Debbie L Kuhlenbeck
    Procter and Gamble Pharmaceuticals, Health Care Research Center, 8700 Mason Montgomery Rd, Mason, OH 45040 8006, USA
    Eur J Mass Spectrom (Chichester, Eng) 11:199-208. 2005
    ..The quantitative analysis of three analytes with differing polarities, dextromethorphan (DEX), dextrorphan (DET) and guaifenesin (GG) in human plasma presented a significant challenge...
  24. ncbi Simultaneous determination of dextromethorphan, dextrorphan, and guaifenesin in human plasma using semi-automated liquid/liquid extraction and gradient liquid chromatography tandem mass spectrometry
    Thomas H Eichhold
    The Procter and Gamble Company, Health Care Research Center, 8700 Mason Montgomery Road, Mason, OH 45040, USA
    J Pharm Biomed Anal 43:586-600. 2007
    A method for the simultaneous determination of dextromethorphan (DEX), dextrorphan (DET), and guaifenesin (GG) in human plasma was developed, validated, and applied to determine plasma concentrations of these compounds in samples from ..
  25. ncbi QT and QTc interval with standard and supratherapeutic doses of darifenacin, a muscarinic M3 selective receptor antagonist for the treatment of overactive bladder
    Denise B Serra
    Exploratory Clinical Development, Novartis Pharmaceuticals Corporation, 435 1159, One Health Plaza, East Hanover, NJ 07936 1080, USA
    J Clin Pharmacol 45:1038-47. 2005
    ..4 and -2.2 milliseconds in the darifenacin 15 mg and 75 mg groups, respectively, compared with +11.6 milliseconds in the moxifloxacin group (P<.01). This study demonstrates that darifenacin does not prolong QT/QTc interval...
  26. ncbi Effect of venlafaxine versus fluoxetine on metabolism of dextromethorphan, a CYP2D6 probe
    J Amchin
    Wyeth-Ayerst Laboratories, 240 North Radnor-Chester Road, St. Davids, PA 19087, USA
    J Clin Pharmacol 41:443-51. 2001
    ..2D6 (CYP2D6) activity, measured by the ratio of dextromethorphan, a sensitive CYP2D6 marker, to its metabolite dextrorphan (i.e., DM:DT) excreted in urine after DM coadministration...
  27. ncbi High-performance liquid chromatography assay for simultaneous determination of dextromethorphan and its main metabolites in urine and in microsomal preparations
    E K Bendriss
    Department of Oncology, McGill University, , , Canada
    J Chromatogr B Biomed Sci Appl 754:209-15. 2001
    An HPLC method has been developed and validated for the determination of dextromethorphan, dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in urine samples...
  28. ncbi Dextromethorphan psychosis, dependence and physical withdrawal
    Shannon C Miller
    Addiction Services, Veterans Administration Medical Center and Associate Professor, Department of Psychiatry, Wright State University School of Medicine, Dayton, OH 45428, USA
    Addict Biol 10:325-7. 2005
    ..A literature review revealed that DM has specific serotonergic and sigma-1 opioidergic properties. Dextrorphan (DOR), the active metabolite of DM, has similar properties; however, DOR is a weaker sigma opioid receptor ..
  29. pmc Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers
    S Hagg
    Division of Clinical Pharmacology, Norrland University Hospital, Umea, Sweden
    Br J Clin Pharmacol 51:169-73. 2001
    ..The study was carried out in order to assess the effects of gender and the use of oral contraceptives (OCs) on CYP2D6 and CYP2C19 activities in healthy volunteers...
  30. ncbi The impact of experimental design on assessing mechanism-based inactivation of CYP2D6 by MDMA (Ecstasy)
    Linh M Van
    Academic Unit of Clinical Pharmacology, University of Sheffield, Pharmacokinetics and Pharmacogenetics Group, Division of Clinical Sciences South, Sheffield, UK
    J Psychopharmacol 20:834-41. 2006
    ..Enzyme activity was measured by the conversion of dextromethorphan (DEX) to dextrorphan (DOR). Dilution factors of 1...
  31. ncbi Effects of N-methyl-D-aspartate receptor antagonism on neuroleptic-induced orofacial dyskinesias
    Spiridon Konitsiotis
    Department of Neurology, University of Ioannina, Medical School University Campus, Ioannina, GR 451 10, Greece
    Psychopharmacology (Berl) 185:369-77. 2006
    ..Tardive dyskinesia is a syndrome of abnormal, involuntary movements, which occurs as a complication of long-term neuroleptic therapy. The pathophysiology of this potentially irreversible syndrome is still an enigma...
  32. ncbi Selective effects of nitric oxide on the disposition of chlorzoxazone and dextromethorphan in isolated perfused rat livers
    Ragini Vuppugalla
    School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    Drug Metab Dispos 34:1160-6. 2006
    ..As for DEM, both NO donors increased (up to 3.5-fold) the recovery of the CYP2D1-mediated metabolite dextrorphan (DOR) in the outlet perfusate...
  33. ncbi CYP2D6 genotype and phenotype in Amerindians of Tepehuano origin and Mestizos of Durango, Mexico
    Martha Sosa-Macias
    Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional del IPN Unidad Durango, CIIDIR IPN, Mexico
    J Clin Pharmacol 46:527-36. 2006
    ..On the other hand, the frequencies of the CYP2D6 variant alleles in Mestizos were similar to those reported for whites...
  34. ncbi Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities?
    A Yu
    Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506 9530, USA
    Drug Metab Dispos 29:1514-20. 2001
    ..In humans, DXM is metabolized to dextrorphan (DXO), as well as 3-methoxymorphinan (MEM) and 3-hydroxymorphinan (HYM)...
  35. ncbi Standardization of method for the analysis of dextromethorphan in urine
    Eun Mi Kim
    Narcotics Analysis Section, National Institute of Scientific Investigation, Yangcheon Gu, Seoul, Republic of Korea
    Forensic Sci Int 161:198-201. 2006
    ..The purpose of this study is to provide a standard method for the analysis of DMP and its main metabolite, dextrorphan (DTP) in biological specimens...
  36. ncbi Dextromethorphan, 3-methoxymorphinan, and dextrorphan have local anaesthetic effect on sciatic nerve blockade in rats
    Chia Hui Hou
    Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan
    Eur J Pharmacol 544:10-6. 2006
    ..The aim of the study was to evaluate whether dextromethorphan and its metabolites--3-methoxymorphinan and dextrorphan--had local anaesthetic effects...
  37. ncbi Effect of sodium ozagrel on the activity of rat CYP2D6
    Hong Wu
    College of Pharmacy, Harbin Medical University, Harbin 150081, PR China Mudanjiang Medical College, Mudanjiang 157011, PR China
    Eur J Pharmacol 573:55-9. 2007
    ..In conclusion, sodium ozagrel metabolism in rats is mediated primarily through CYP2D6, and sodium ozagrel can induce CYP2D6 activity...
  38. ncbi Effect of cinacalcet hydrochloride, a new calcimimetic agent, on the pharmacokinetics of dextromethorphan: in vitro and clinical studies
    Daisuke Nakashima
    Product Development Department, Pharmaceutical Division, Kirin Brewery Company Ltd, 26 1 Jingumae 6 chome, Shibuya ku, Tokyo, 150 8011, Japan
    J Clin Pharmacol 47:1311-9. 2007
    ..Therefore, during concomitant treatment with cinacalcet, it may be necessary to consider making dose adjustments for drugs with a narrow therapeutic index that are mainly metabolized by CYP2D6...
  39. ncbi Determination of dextromethorphan and its metabolite dextrorphan in human urine using high performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry: a study of selectivity of a tandem mass spectrometric assa
    M L Constanzer
    Merck Research Laboratories, West Point, PA 19486, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 816:297-308. 2005
    Analytical method for the simultaneous determination of dextromethorphan (1) and dextrorphan (2) in urine, based on solid-phase extraction of drug from acidified hydrolyzed biological matrix, were developed...
  40. ncbi Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers
    Jennifer L Donovan
    Laboratory of Drug Disposition and Pharmacogenetics, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Drug Metab Dispos 32:1333-6. 2004
    ....
  41. ncbi Dextromethorphan metabolic phenotyping in an Iranian population
    Minoo Afshar
    Biopharmaceutics and Pharmacokinetics Division, Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, P O Box 14155 6451, Tehran, Iran
    Eur J Clin Pharmacol 60:849-54. 2005
    ..CYP2D6 polymorphism of drug metabolism represents an important source of interindividual and interethnic variation in drug response. Since this polymorphism has not been studied in an Iranian population, the present study was undertaken...
  42. ncbi Plasma profile and pharmacokinetics of dextromethorphan after intravenous and oral administration in healthy dogs
    B Kukanich
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    J Vet Pharmacol Ther 27:337-41. 2004
    ..A metabolite of dextromethorphan, dextrorphan, has been shown to behave pharmacodynamically in a similar manner to dextromethorphan...
  43. ncbi Comparison of the effects of dextromethorphan, dextrorphan, and levorphanol on the hypothalamo-pituitary-adrenal axis
    Robert N Pechnick
    Department of Psychiatry and Mental Health, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Pharmacol Exp Ther 309:515-22. 2004
    ..It is metabolized in vivo to dextrorphan, a more potent noncompetitive NMDA antagonist that is the dextrorotatory enantiomer of the opioid agonist ..
  44. ncbi Analgesic effect of dextromethorphan in neuropathic pain
    K C Carlsson
    Department of Pharmacology, School of Pharmacy, University of Oslo, Oslo, Norway
    Acta Anaesthesiol Scand 48:328-36. 2004
    ..The aim of this study was to evaluate the analgesic and adverse effects of a single high dose of dextromethorphan on spontaneous pain in patients suffering long-term neuropathic pain of traumatic origin...
  45. ncbi Effect of dextrometorphan and dextrorphan on nicotine and neuronal nicotinic receptors: in vitro and in vivo selectivity
    M I Damaj
    Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Box 980613, Richmond, VA 23298 0613, USA
    J Pharmacol Exp Ther 312:780-5. 2005
    The effects of dextrometorphan and its metabolite dextrorphan on nicotine-induced antinociception in two acute thermal pain assays after systematic administration were evaluated in mice and compared with that of mecamylamine...
  46. ncbi Development of a chromatographic bioreactor based on immobilized beta-glucuronidase on monolithic support for the determination of dextromethorphan and dextrorphan in human urine
    E Calleri
    Department of Pharmaceutical Chemistry, University of Pavia, Via Taramelli 12, Pavia I 27100, Italy
    J Pharm Biomed Anal 35:1179-89. 2004
    ..based on beta-glucuronidase to the on-line determination of urinary molar ratios of dextromethorphan (DOMe)/dextrorphan (DOH) for the assessment of the metabolic activity of CYP2D6, a genetically variable isoform of cytochrome P-..
  47. ncbi Metabolic activity of dextromethorphan O-demethylation in healthy Japanese volunteers carrying duplicated CYP2D6 genes: duplicated allele of CYP2D6*10 does not increase CYP2D6 metabolic activity
    Akihiro Ishiguro
    Department of Pharmacy, Faculty of Medicine, University of Tokyo Hospital, 7 3 1 Hongoh, Bunkyo, Tokyo 113 8655, Japan
    Clin Chim Acta 344:201-4. 2004
    ..This study was designed to assess the metabolic activities of dextromethorphan O-demethylation in healthy Japanese subjects carrying duplicated CYP2D6 alleles, CYP2D6*1 x 2, CYP2D6*2 x 2 or CYP2D6*10 x 2...
  48. ncbi Analysis of pharmacokinetic parameters for assessment of dextromethorphan metabolic phenotypes
    Geng Chang Yeh
    Department of Pediatrics, Taipei Medical University Hospital, Graduate Institute of Medical Science, College of Medicine, Taipei, Taiwan, ROC
    J Biomed Sci 10:552-64. 2003
    In this study, the metabolic ratios of dextromethorphan to dextrorphan (DM/DX) in plasma were calculated at steady state after administering 2 dosage forms (Medicon) and Detusiv) of DM with different release rates...
  49. pmc Physiologically based modelling of inhibition of metabolism and assessment of the relative potency of drug and metabolite: dextromethorphan vs. dextrorphan using quinidine inhibition
    A A Moghadamnia
    Molecular Pharmacology and Pharmacogenetics, Division of Clinical Sciences South, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Br J Clin Pharmacol 56:57-67. 2003
    To define the relative antitussive effect of dextromethorphan (DEX) and its primary metabolite dextrorphan (DOR) after administration of DEX.
  50. ncbi Brain levels of dextromethorphan and the intensity of opioid withdrawal in mice
    Adam Bisaga
    Division on Substance Abuse, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Drug Alcohol Depend 95:147-51. 2008
    ..actions at N-methyl-D-aspartate type glutamate receptors, dextromethorphan (DXM) and its metabolite, dextrorphan (DXT) decrease the intensity of opioid withdrawal syndrome...
  51. pmc Clinical inhibition of CYP2D6-catalysed metabolism by the antianginal agent perhexiline
    Benjamin J L Davies
    Department of Cardiology and Clinical Pharmacology, The Queen Elizabeth Hospital, Woodville 5011, South Australia, Australia
    Br J Clin Pharmacol 57:456-63. 2004
    ..The aim of this study was to determine whether perhexiline produces clinically significant inhibition of CYP2D6-catalysed metabolism in angina patients...
  52. ncbi Affinity and specificity of N-methyl- D-aspartate channel blockers affect their ability to disrupt prepulse inhibition of acoustic startle in rats
    Jenny L Wiley
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, PO Box 980613, Richmond, VA 23298 0613, USA
    Psychopharmacology (Berl) 165:378-85. 2003
    ..Recently, a number of low-affinity NMDA channel blockers that exhibit minimal PCP-like effects in humans at therapeutic doses have been developed...
  53. ncbi Sol-gel-based solid-phase microextraction and gas chromatography-mass spectrometry determination of dextromethorphan and dextrorphan in human plasma
    Habib Bagheri
    Department of Chemistry, Sharif University of Technology, Azadi Av, P O Box 11365 9516, Tehran, Iran
    J Chromatogr B Analyt Technol Biomed Life Sci 818:147-57. 2005
    ..microextraction (SPME) method was developed for isolation of dextromethorphan (DM) and its main metabolite dextrorphan (DP) from human plasma followed by GC-MS determination...
  54. ncbi Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats
    Shaoyu Zhang
    Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China
    J Chromatogr B Analyt Technol Biomed Life Sci 871:78-89. 2008
    ..and carboxytolbutamide (CYP2C9), mephenytoin/4'-hydroxymephenytoin (CYP2C19), dextromethorphan/dextrorphan (CYP2D6), and midazolam/1'-hydroxymidazolam (CYP3A)...
  55. ncbi Discrimination of a single dose of morphine followed by naltrexone: substitution of other agonists for morphine and other antagonists for naltrexone in a rat model of acute dependence
    Stephen G Holtzman
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Pharmacol Exp Ther 304:1033-41. 2003
    ..on the saline-->naltrexone-appropriate lever when naltrexone was administered after pretreatment with dextrorphan, the dextrorotatory isomer of levorphanol, or kappa-opioid agonists (5-alpha,7-alpha,8-beta)-(+)-N-methyl-N-[7-(..
  56. ncbi Six-month, prospective, longitudinal, open-label caffeine and dextromethorphan phenotyping study in children with growth hormone deficiency receiving recombinant human growth hormone replacement
    Mary Jayne Kennedy
    Kosair Charities Pediatric Clinical Research Unit, Department of Pediatrics, School of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    Clin Ther 30:1687-99. 2008
    ..Although growth hormone (GH) may alter the clearance of concomitantly administered medications, its effects on individual drug-metabolizing enzymes in children have not been characterized...
  57. ncbi In-vivo indices of CYP2D6 activity: comparison of dextromethorphan metabolic ratios in 4-h urine and 3-h plasma
    J Chladek
    Department of Pharmacology, Faculty of Medicine, Charles University, Hradec Kralove, Czech Republic
    Eur J Clin Pharmacol 56:651-7. 2000
    ..The aim of the study was to compare metabolic ratios (MRs) of DM to dextrorphan (DEX) in plasma and urine...
  58. ncbi Effect of metabolic blockade on the psychoactive effects of dextromethorphan
    Laurie A Zawertailo
    Centre for Addiction and Mental Health, Nicotine Dependence Clinic, Toronto, Ontario, Canada
    Hum Psychopharmacol 25:71-9. 2010
    ..affects the pharmacokinetics and effectiveness of dextromethorphan (DM), because it controls the production of dextrorphan, an active metabolite, with higher affinity for the NMDA receptor than the parent compound...
  59. ncbi Discriminative stimulus effects of the PCP/sigma-ligand (+)-N-allylnormetazocine in monkeys
    S G Holtzman
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322
    Pharmacol Biochem Behav 44:349-55. 1993
    ..and the PCP-like drugs MK-801 and thienylcyclohexyl-piperidine, and by the opioids (+)- and (-)-cyclazocine and dextrorphan; order of potency correlated with reported affinities for the PCP receptor...
  60. ncbi Phenotyping polymorphic drug metabolism in the French Caucasian population
    E Jacqz
    INSERM Unité 120, Le Vesinet, France
    Eur J Clin Pharmacol 35:167-71. 1988
    ..Individual dextrorphan excretion over 8 h and the dextromethorphan/dextrorphan metabolic ratio were calculated...
  61. ncbi Effect of conjugated equine estrogens on oxidative metabolism in middle-aged and elderly postmenopausal women
    Mary Beth O'Connell
    Pharmacy Practice Department Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201 2427, USA
    J Clin Pharmacol 46:1299-307. 2006
    ..57 +/- 0.20 before, 0.40 +/- 0.20 after, P = .001) and significantly increased CYP2D6 (dextromethorphan/dextrorphan ratio: 0.0116 +/- 0.0143 before, 0.0084 +/- 0.0135 after, P = .022) metabolism...
  62. ncbi Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects
    F I al-Jenoobi
    Departments of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
    Drug Metab Lett 4:51-5. 2010
    ..To investigate the effects of black seed on the metabolic activities of CYP3A4 and CYP2D6 in human liver microsomes and in human subjects using dextromethorphan as a probe drug...
  63. ncbi High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry
    Samuel A Testino
    Bioanalytical Department, Solvay Pharmaceuticals, Inc, 901 Sawyer Road, Marietta, GA 30062, USA
    J Pharm Biomed Anal 30:1459-67. 2003
    ..The metabolic reactions were terminated with methanol containing dextrorphan as an internal standard...
  64. ncbi Pharmacokinetic drug interaction potential of risperidone with cytochrome p450 isozymes as assessed by the dextromethorphan, the caffeine, and the mephenytoin test
    C B Eap
    Unit of Biochemistry and Clinical Psychopharmacology, University Department of Adult Psychiatry, Cery Hospital, CH Prilly Lausanne, Switzerland
    Ther Drug Monit 23:228-31. 2001
    ..dextromethorphan metabolic ratio is significantly increased by risperidone (median urinary dextromethorphan/dextrorphan ratios before and after risperidone: 0.010, 0.018; p = 0...
  65. ncbi Inhibition of CYP2D6 activity by bupropion
    Michael Kotlyar
    Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Twin Cities Campus, Minneapolis, MN 55455, USA
    J Clin Psychopharmacol 25:226-9. 2005
    ..To assess CYP2D6 activity, urinary dextromethorphan/dextrorphan metabolic ratios were calculated after an 8-hour urine collection...
  66. ncbi New morphinan derivatives with negligible psychotropic effects attenuate convulsions induced by maximal electroshock in mice
    Hyoung Chun Kim
    Neurotoxicology Program, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, Chunchon 200 701, South Korea
    Life Sci 72:1883-95. 2003
    ..Repeated treatment (20 or 40 mg/kg, i.p./day x 7) with DM or dextrorphan (a major metabolite of DM; DX) significantly enhanced locomotor activity in a dose-related manner...
  67. ncbi Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O-demethylation by terbinafine
    S M Abdel-Rahman
    Section of Pediatric Clinical Pharmacology and Experimental Therapeutics, The Children s Mercy Hospital, Kansas City, Missouri 64108, USA
    Drug Metab Dispos 27:770-5. 1999
    ..and heterologously expressed CYP2D6 were incubated with terbinafine or quinidine and the formation of dextrorphan from dextromethorphan was determined by HPLC...
  68. ncbi High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1
    H Z Bu
    Department of Metabolic Chemistry, Covance Laboratories, Inc, 3301 Kinsman Boulevard, Madison, WI 53704, USA
    Rapid Commun Mass Spectrom 15:741-8. 2001
    ..with formic acid, the five marker metabolites (7-hydroxycoumarin, 1'-hydroxymidazolam, 4-hydroxytolbutamide, dextrorphan, and 6-hydroxychlorzoxazone) were simultaneously quantified using direct injection/online guard cartridge ..
  69. ncbi Characterization of [3H]Met-enkephalin-Arg6-Phe7 binding to multiple sites in rat and guinea pig cerebellum
    S Benyhe
    Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Szeged
    Life Sci 64:1189-96. 1999
    ..as demonstrated by the difference in the affinities of the enantiomeric compounds levorphanol and dextrorphan, therefore it would represent an opioid site...
  70. ncbi Dextromethorphan-induced near-fatal suicide attempt in a slow metabolizer at cytochrome P450 2D6
    Nadia Matin
    Department of Psychiatry, New Jersey Medical School UMDNJ, Newark, New Jersey 07103, USA
    Am J Geriatr Pharmacother 5:162-5. 2007
    ..Its metabolism in humans includes hepatic O- and N-demethylation to form dextrorphan and 3-methoxymorphinan, respectively, followed by conjugation...
  71. ncbi Discriminative stimulus effects of dextromethorphan in the rat
    S G Holtzman
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322 3090
    Psychopharmacology (Berl) 116:249-54. 1994
    ..b>Dextrorphan, a metabolite of dextromethorphan, has phencyclidine (PCP)-like effects...
  72. ncbi GC and GC-MS procedures for simultaneous phenotyping with dextromethorphan and mephenytoin
    P Baumann
    Clinique Psychiatrique Universitaire de Lausanne, Hôpital de Cery, Prilly, Switzerland
    Clin Chim Acta 171:211-22. 1988
    ..and mephenytoin may be revealed by the excretion pattern of dextromethorphan and its metabolite dextrorphan, and mephenytoin, 4-OH-mephenytoin, respectively, after a single dose of the test drugs...
  73. ncbi In-vivo and in-vitro dextromethorphan metabolism in SD and DA rat. An animal model of the debrisoquine-type polymorphic oxidation in man
    T Zysset
    Department of Clinical Pharmacology, Berne, Switzerland
    Biochem Pharmacol 37:3155-60. 1988
    ..of 50 mg/kg of DEM, the DA rat excreted 25 +/- 6% of the dose in 72-hr urine as O-demethylated product (dextrorphan), whereas the SD excreted 40 +/- 9% (P less than 0.002). Metabolic ratio of O-demethylation was 0.46 +/- 0...
  74. ncbi Effect of the NMDA-receptor antagonist dextromethorphan in infant rat pneumococcal meningitis
    Johann Sellner
    Department of Neurology, Inselspital, Bern University Hospital, Switzerland
    Curr Drug Metab 9:83-8. 2008
    ..Pharmacokinetics of DM and its major metabolite dextrorphan (DO) were performed for dose finding...
  75. ncbi Effect of interferon alpha-ribavirin bitherapy on cytochrome P450 1A2 and 2D6 and N-acetyltransferase-2 activities in patients with chronic active hepatitis C
    Laurent Becquemont
    Department of Pharmacology and the Clinical Investigation Center, Saint Antoine University Hospital, Paris, France
    Clin Pharmacol Ther 71:488-95. 2002
    ..Interferon alpha (IFN-alpha) is thought to be responsible for cytochrome P450 (CYP)-dependent drug interactions mediated by a decrease in CYP activities...
  76. ncbi Effect of PCP and sigma ligands on both noradrenaline- and electrically-induced contractions and on [3H]-noradrenaline uptake in rat vas deferens
    D Pubill
    , , Universitat de Barcelona, Spain
    J Auton Pharmacol 18:239-44. 1998
    ..microM) by different sigma and PCP receptor ligands (PCP, TCP, (+)-MK-801, dextromethorphan and (+)-3-PPP); dextrorphan did it in a minor extent. 2...
  77. pmc Effects of drugs and drug combinations in pigeons trained to discriminate among pentobarbital, dizocilpine, a combination of these drugs, and saline
    D E McMillan
    University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 7199, USA
    J Exp Anal Behav 92:387-412. 2009
    ..The highest doses of dextromethorphan or dextrorphan resulted in responding on the dizocilpine key more frequently than on other keys...
  78. ncbi Effects of steady-state lasofoxifene on CYP2D6- and CYP2E1-mediated metabolism
    Robert A Moller
    Pfizer Worldwide Clinical Development, New York, NY 10017 5755, USA
    Ann Pharmacother 40:32-7. 2006
    ..Lasofoxifene, a selective estrogen receptor modulator, may be coadministered with other drugs, raising the issue of drug-drug interactions...
  79. ncbi The effect of CYP2D6 polymorphisms on dextromethorphan metabolism in Mexican Americans
    Paul R Casner
    Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA
    J Clin Pharmacol 45:1230-5. 2005
    ..and analyzed by high-performance liquid chromatography to calculate the metabolic ratio of dextromethorphan to dextrorphan. Blood samples were collected for genotypic analysis of CYP2D6 alleles...
  80. ncbi Neuropsychotoxicity of abused drugs: potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effects
    Eun Joo Shin
    Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, Korea
    J Pharmacol Sci 106:22-7. 2008
    ..Accumulating evidence suggests that metabolism to phencyclidine-like dextrorphan is not essential for the neuroprotective activity of dextromethorphan...
  81. ncbi Characterization of [3H]nisoxetine binding in rat vas deferens membranes: modulation by sigma and PCP ligands
    D Pubill
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Universitat de Barcelona, Spain
    Life Sci 62:763-73. 1998
    ..ligands tested, with the following order of potency: haloperidol > dextromethorphan > dizocilpine > dextrorphan > (+)-3-PPP > PCP > tenocyclidine...
  82. ncbi Pharmacokinetic comparison of a dextromethorphan-salbutamol combination tablet and a plain dextromethorphan tablet
    M Silvasti
    Medical Department, Orion Corporation, Orion Pharmaceutica, Kuopio, Finland
    Int J Clin Pharmacol Ther Toxicol 28:268-72. 1990
    ..combination tablet (Redol comp) and from a plain dextromethorphan tablet (Extuson) by determining dextrorphan concentrations after single-dose oral administration in 10 healthy volunteers...
  83. ncbi Simultaneous quantification of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in human plasma by ultra performance liquid chromatography/tandem triple-quadrupole mass spectrometry
    Walter J Loos
    Department of Medical Oncology, Erasmus MC Daniel den Hoed Cancer Center, University Medical Center, Rotterdam, The Netherlands
    J Pharm Biomed Anal 54:387-94. 2011
    ..and validated for the simultaneous quantitative determination of dextromethorphan (DM) and its metabolites dextrorphan (DX), 3-methoxymorphinan (3MM) and 3-hydroxymorphinan (3HM), in human lithium heparinized plasma...
  84. ncbi Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans
    Andrea Gaedigk
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospital and Clinics, Kansas City, MO 64108 USA
    Clin Pharmacol Ther 72:76-89. 2002
    ..Although CYP2D6 has been studied extensively in different population groups, relatively little is known for black Americans...
  85. ncbi [Pharmacogenetic study of the response to flecainide and propafenone in patients with atrial fibrillation]
    Manuel Martinez-Selles
    Servicio de Cardiologia, Hospital Universitario Gregorio Maranon, Madrid, Spain
    Rev Esp Cardiol 58:745-8. 2005
    ..polymorphism by determining phenotype as the metabolic ratio between dextromethorphan and its main metabolite, dextrorphan. We studied 18 men and 22 women in whom mean age was 54.6+/-11.9 years...
  86. ncbi N-Methyl-D-aspartate receptor antagonists enhance the head-twitch response, a 5-hydroxytryptamine2 receptor-mediated behaviour, in reserpine-treated mice
    H S Kim
    Department of Pharmacology, College of Pharmacy, Chungbuk National University, Cheongju, Korea
    J Pharm Pharmacol 52:717-22. 2000
    ..acid (CPP), (+)-5-methyl-10,11-dihydroxy-5H-dibenzo-[a,d]-cyclohepten-5,10-imi ne (MK-801), ketamine, dextrorphan and dextromethorphan) with 5-HT neurones, vesicle stores of monoamines, especially 5-HT, were depleted with ..
  87. ncbi Measurement of CYP2D6 and CYP3A4 activity in vivo with dextromethorphan: sources of variability and predictors of adverse effects in 419 healthy subjects
    Christian Funck-Brentano
    INSERM AP HP, Clinical Investigation Center, CIC 9304, and Department of Pharmacology, Pierre et Marie Curie University, 75012 Paris, France
    Eur J Clin Pharmacol 61:821-9. 2005
    ....
  88. ncbi Microbial transformation of dextromethorphan by Cunninghamella blakesleeana AS 3.153
    Lihong Lin
    Shenyang Pharmaceutical University, China
    Chem Pharm Bull (Tokyo) 55:658-61. 2007
    ..153 were detected by liquid chromatography-tandem mass spectrometry (LC-MS(n)) and the metabolite dextrorphan was identified by reference to confirm its structure. The yield of dextrorphan produced by C. blakesleeana AS 3...
  89. ncbi Attenuation of the stimulant and convulsant effects of cocaine by 17-substituted-3-hydroxy and 3-alkoxy derivatives of dextromethorphan
    Agustin Zapata
    Drug Development Group, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Pharmacol Biochem Behav 74:313-23. 2003
    ..In contrast to the high-affinity NMDA blockers, (+)-MK-801 (dizocilpine) and dextrorphan (DX), DM and analogs did not stimulate locomotor activity...
  90. ncbi [Cardiovascular effect mediated by phencyclidine receptor in central nervous system]
    C X Yu
    Department of Neurobiology, Shanghai Medical University
    Sheng Li Xue Bao 42:45-52. 1990
    ..The hypotension and bradycardia of ith PCP (150 nmol) were significantly antagonized by ith 15 nmol dextrorphan. TCP, an agonist of PCP receptor, also elicited sharp hypotension and bradycardia immediately...
  91. ncbi An optimized methodology for combined phenotyping and genotyping on CYP2D6 and CYP2C19
    W J Tamminga
    Pharma Bio Research Group BV, Science Park, NL 9471 GP Zuidlaren, The Netherlands
    Eur J Clin Pharmacol 57:143-6. 2001
    ..Blood samples were collected and analysed for dextromethorphan, dextrorphan, metoprolol, alpha-hydroxymetoprol, omeprazole and 5-hydroxyomeprazole by HPLC...
  92. ncbi Polymorphism of dextromethorphan oxidation in Polish population
    Jadwiga Skretkowicz
    Departament of Pharmacogenetics, Medical University of Lodz, 1 Muszynskiego St, PL 90 151 Lodz, Poland
    Acta Pol Pharm 65:611-5. 2008
    ..DM and the metabolite dextrorphan (DT) were analyzed by HPLC method...
  93. ncbi LC-MS/MS analysis of dextromethorphan metabolism in human saliva and urine to determine CYP2D6 phenotype and individual variability in N-demethylation and glucuronidation
    Ursula Lutz
    Department of Toxicology, University of Wurzburg, Versbacher Str 9, D 97078 Wurzburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 813:217-25. 2004
    ..phenotype a sensitive LC-MS/MS assay to quantify dextromethorphan (DEX) and its O-demethylated metabolite dextrorphan (DOR) in human saliva was developed with limits of quantitation of 1 pmol/ml...
  94. ncbi An evaluation of the drug interaction potential of pazopanib, an oral vascular endothelial growth factor receptor tyrosine kinase inhibitor, using a modified Cooperstown 5+1 cocktail in patients with advanced solid tumors
    B C Goh
    Section of Clinical Pharmacology, Department of Hematology Oncology, National University Hospital, Singapore, Singapore
    Clin Pharmacol Ther 88:652-9. 2010
    ..30); and S-warfarin, 0.93 (0.84-1.03). The geometric least-squares (LS) mean ratio of urine dextromethorphan:dextrorphan ranged from 1.33 (0-4-h interval) to 1.64 (4-8-h interval)...
  95. ncbi Clonidine as adjuvant for oxybuprocaine, bupivacaine or dextrorphan has a significant peripheral action in intensifying and prolonging analgesia in response to local dorsal cutaneous noxious pinprick in rats
    Yu Wen Chen
    Department of Physical Therapy, China Medical University, Taichung, Taiwan
    Neurosci Lett 496:186-90. 2011
    ..was to evaluate co-administration of clonidine with oxybuprocaine (ester type), bupivacaine (amide type) or dextrorphan (non-ester or non-amide type) and to see whether it could have a peripheral action in enhancing local ..
  96. ncbi Dynamics and persistence of CYP2D6 inhibition by paroxetine
    J Jurica
    Department of Pharmacology, Faculty of Medicine, Central European Institute of Technology CEITEC, Masaryk University, Brno, Czech Republic
    J Clin Pharm Ther 38:294-300. 2013
    ..Paroxetine is both a substrate and an inhibitor of CYP2D6. The objective of the presented study was to determine the persistence of CYP2D6 inhibition after short term (6 weeks) and long term (18·7 ± 10·6 weeks) paroxetine treatment...
  97. ncbi Study of dried blood spots technique for the determination of dextromethorphan and its metabolite dextrorphan in human whole blood by LC-MS/MS
    Xiaorong Liang
    Department of Bioanalytical Chemistry, Covance Laboratories Inc, 3301 Kinsman Blvd, Madison, WI 53704, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:799-806. 2009
    ..DBSs) technology was evaluated in an assay for the quantitation of dextromethorphan (DM) and its metabolite, dextrorphan (DT), in human whole blood using high performance liquid chromatography with tandem mass spectrometry method (..
  98. ncbi Theoretical studies on the structure and symmetry of the transmembrane region of glutamatergic GluR5 receptor
    Agnieszka A Kaczor
    Department of Synthesis and Chemical Technology of Pharmaceutical Substances, Faculty of Pharmacy, Medical University of Lublin, 6 Staszica Str, 20081 Lublin, Poland
    J Med Chem 51:3765-76. 2008
    ..validated by building of NMDA receptor transmembrane region model and its evaluation in the docking of dextrorphan, (+)-MK-801, and IEM-1925...
  99. ncbi Development of CYP2D6 and CYP3A4 in the first year of life
    T N Johnson
    Clin Pharmacol Ther 83:670-1. 2008
  100. ncbi Opioid peptides and receptors in joint tissues: study in the rat
    Jonas Bergstrom
    Department of Molecular Medicine and Surgery, Section of Orthopaedics, Karolinska Institutet, Orthopaedic Research Laboratory, Karolinska Hospital, S 171 76 Stockholm, Sweden
    J Orthop Res 24:1193-9. 2006
    ..The endogenous opioid system now demonstrated might be targeted and exploited therapeutically to obtain peripheral control of symptoms in joint disorders...
  101. ncbi Rapid and sensitive HPLC-MS/MS method for quantitative determination of lycorine from the plasma of rats
    Xin Liu
    Department of Drug Metabolism, Key Laboratory of Active Substances Discovery and Drug Ability Evaluation, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China
    J Chromatogr B Analyt Technol Biomed Life Sci 974:96-100. 2015
    ..Plasma samples were prepared by a simple protein precipitation with methanol containing dextrorphan as internal standard. The chromatographic separation was performed on a Kromasil 60-5CN column (3μm, 2...

Research Grants24

  1. Exogenous and Endogenous Biomarkers of CYP2D6 Variability in Pediatrics
    YVONNE SARAH LIN; Fiscal Year: 2013
    ..or "metabolizer" status is assigned based on the relative amounts of DM and the metabolite produced by CYP2D6, dextrorphan (DX), present in the urine sample...
  2. DEXTROROTATORY OPIOIDS AS PROBES FOR PCP RECEPTORS
    Thomas Murray; Fiscal Year: 1999
    b>Dextrorphan, (+)3-hydroxy-N-methyl-morphinan, is a selective noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) class of excitatory amino acid receptors...
  3. PK-PD Models: The Role of Metabolites in Drug Action
    Howard Hendrickson; Fiscal Year: 2004
    ..The applicant will investigate the role of dextrorphan, the primary active metabolite of dextromethorphan, as the agent responsible for the phencyclidine-like actions ..
  4. CYTOCHROME P450 ACTIVITY IN THE FIRST YEAR OF LIFE
    JAMES LEEDER; Fiscal Year: 1999
    ..Quantitation of dextromethorphan and its metabolite, dextrorphan, provides a direct assessment of CYP2D6 activity. Specifically, a 0...
  5. Ginkgo biloba for ECT-induced Memory Deficits
    JOHN MARKOWITZ; Fiscal Year: 2003
    ..will utilize larger groups and additional cognitive tests will be incorporated to provide more definitive conclusions regarding efficacy, optimal dose and duration, persistence of effects, and safety and tolerability ..
  6. Screening Herbs for Drug Interactions
    JOHN MARKOWITZ; Fiscal Year: 2002
    ..Further, the proposed studies will complement existing and future NCCAM studies of agents such as St. John's wort and Gingko biloba. ..
  7. P-Glycoprotein and Disposition of Psychostimulants
    JOHN MARKOWITZ; Fiscal Year: 2005
    ....
  8. Evaluating Trichophyton tonsurans Carriage and Infection
    Susan Abdel Rahman; Fiscal Year: 2006
    ..abstract_text> ..
  9. FUNGAL PROTEIN/GLYCOPROTEIN EXPRESSION IN TINEA CAPITIS
    Susan Abdel Rahman; Fiscal Year: 2003
    ..abstract_text> ..
  10. BEHAVIORAL PHARMACOLOGY OF NARCOTIC ANTAGONISTS
    STEPHEN HOLTZMAN; Fiscal Year: 2002
    ..Acute agonist-induced sensitization to opioid antagonists appears to be an exquisite example of neuronal plasticity, reflecting the first hours of the drug-receptor interactions that lead to chronic physical dependence upon opioids. ..
  11. BEHAVIORAL PHARMACOLOGY OF OPIOIDS
    STEPHEN HOLTZMAN; Fiscal Year: 2004
    ....
  12. Docosanol and Acyclovir for Treating Genital Herpes
    LAURA POPE; Fiscal Year: 2003
    ..If proven safe and effective, it would provide a new single agent treatment as well as allow concurrent use with acyclovir. PROPOSED COMMERCIAL APPLICATION: Topical treatment for recurrent genital herpes infections. ..
  13. DIENCEPHALIC MECHANISMS OF DRUG ABUSE
    STANLEY GLICK; Fiscal Year: 2008
    ..The work proposed here may ultimately result in new kinds of treatments for drug abuse. ..
  14. Urinary proteomics in aminoglycoside treated newborns
    Mary Kennedy; Fiscal Year: 2008
    ..The results of this research may allow us to identify infants who are at risk for developing significant injury before it occurs. [unreadable] [unreadable] [unreadable]..
  15. Differential Effects of Antidepressants in Adult and Developing Animals
    ROBERT PECHNICK; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  16. Effect of Diet on Drug Metabolism in Infants
    Michael Blake; Fiscal Year: 2003
    ..abstract_text> ..
  17. Maternal Separation: Rat Model of Opioid Vulnerability
    STEPHEN HOLTZMAN; Fiscal Year: 2006
    ..abstract_text> ..
  18. NEUROBEHAVIORAL MECHANISMS OF DRUG ADDICTION
    STANLEY GLICK; Fiscal Year: 2001
    ..This research may result in novel treatments for addictive disorders in humans. ..
  19. Mechanisms of Atypical Drug Kinetics and Interactions
    TIMOTHY TRACY; Fiscal Year: 2008
    ..From these data, computer models will be developed to predict the occurrence of atypical kinetics and potential drug interactions to assist in the drug development process. ..
  20. Viral-Mediated CRH Expression and Depression
    ROBERT PECHNICK; Fiscal Year: 2008
    ..abstract_text> ..
  21. PHARMACOLOGY & NEUROSCIENCE TRAINING IN DRUG ABUSE
    STANLEY GLICK; Fiscal Year: 2008
    ..All aspects of the program are administered by the director and an executive committee of administrative and training faculty. ..
  22. ANTIRETROVIRAL PHARMACOLOGY IN THE GENITAL TRACT
    Angela Kashuba; Fiscal Year: 2007
    ..abstract_text> ..
  23. PharmGKB Experimental Biology Workshop 2005
    TIMOTHY TRACY; Fiscal Year: 2005
    ....