lymphatic metastasis

Summary

Summary: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.

Top Publications

  1. ncbi Immune infiltration in human tumors: a prognostic factor that should not be ignored
    F Pages
    Inserm U872, Centre de Recherche des Cordeliers, Equipe 15, Paris, France
    Oncogene 29:1093-102. 2010
  2. ncbi Involvement of chemokine receptors in breast cancer metastasis
    A Muller
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 410:50-6. 2001
  3. ncbi Gene expression profiling predicts clinical outcome of breast cancer
    Laura J van 't Veer
    Division of Diagnostic Oncology, The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, The Netherlands
    Nature 415:530-6. 2002
  4. ncbi A gene-expression signature as a predictor of survival in breast cancer
    Marc J van de Vijver
    Division of Diagnostic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    N Engl J Med 347:1999-2009. 2002
  5. ncbi A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    Soonmyung Paik
    Division of Pathology, Operation Center, and the Biostatistics Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh 15212, USA
    N Engl J Med 351:2817-26. 2004
  6. ncbi Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer
    Yixin Wang
    Veridex LLC, a Johnson and Johnson Company, San Diego, CA, USA
    Lancet 365:671-9. 2005
  7. ncbi Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer
    Soonmyung Paik
    Division of Pathology, Operations Center, and Biostatistical Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212, USA
    J Clin Oncol 24:3726-34. 2006
  8. ncbi Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis
    Christos Sotiriou
    Functional Genomics and Translational Research Unit, Universite Libre de Bruxelles, Brussels, Belgium
    J Natl Cancer Inst 98:262-72. 2006
  9. ncbi Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial
    Armando E Giuliano
    John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
    JAMA 305:569-75. 2011
  10. ncbi VEGF-D promotes the metastatic spread of tumor cells via the lymphatics
    S A Stacker
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
    Nat Med 7:186-91. 2001

Detail Information

Publications316 found, 100 shown here

  1. ncbi Immune infiltration in human tumors: a prognostic factor that should not be ignored
    F Pages
    Inserm U872, Centre de Recherche des Cordeliers, Equipe 15, Paris, France
    Oncogene 29:1093-102. 2010
    ....
  2. ncbi Involvement of chemokine receptors in breast cancer metastasis
    A Muller
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 410:50-6. 2001
    ..Our findings indicate that chemokines and their receptors have a critical role in determining the metastatic destination of tumour cells...
  3. ncbi Gene expression profiling predicts clinical outcome of breast cancer
    Laura J van 't Veer
    Division of Diagnostic Oncology, The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, The Netherlands
    Nature 415:530-6. 2002
    ..This gene expression profile will outperform all currently used clinical parameters in predicting disease outcome. Our findings provide a strategy to select patients who would benefit from adjuvant therapy...
  4. ncbi A gene-expression signature as a predictor of survival in breast cancer
    Marc J van de Vijver
    Division of Diagnostic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    N Engl J Med 347:1999-2009. 2002
    ..A more accurate means of prognostication in breast cancer will improve the selection of patients for adjuvant systemic therapy...
  5. ncbi A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    Soonmyung Paik
    Division of Pathology, Operation Center, and the Biostatistics Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh 15212, USA
    N Engl J Med 351:2817-26. 2004
    ..The likelihood of distant recurrence in patients with breast cancer who have no involved lymph nodes and estrogen-receptor-positive tumors is poorly defined by clinical and histopathological measures...
  6. ncbi Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer
    Yixin Wang
    Veridex LLC, a Johnson and Johnson Company, San Diego, CA, USA
    Lancet 365:671-9. 2005
    ....
  7. ncbi Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer
    Soonmyung Paik
    Division of Pathology, Operations Center, and Biostatistical Center, National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA 15212, USA
    J Clin Oncol 24:3726-34. 2006
    ..The relationship between the RS and chemotherapy benefit is not known...
  8. ncbi Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis
    Christos Sotiriou
    Functional Genomics and Translational Research Unit, Universite Libre de Bruxelles, Brussels, Belgium
    J Natl Cancer Inst 98:262-72. 2006
    ..We examined whether histologic grade was associated with gene expression profiles of breast cancers and whether such profiles could be used to improve histologic grading...
  9. ncbi Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial
    Armando E Giuliano
    John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
    JAMA 305:569-75. 2011
    ..Sentinel lymph node dissection (SLND) accurately identifies nodal metastasis of early breast cancer, but it is not clear whether further nodal dissection affects survival...
  10. ncbi VEGF-D promotes the metastatic spread of tumor cells via the lymphatics
    S A Stacker
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
    Nat Med 7:186-91. 2001
    ..This study demonstrates that lymphatics can be established in solid tumors and implicates VEGF family members in determining the route of metastatic spread...
  11. ncbi Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
    Jerome Galon
    INSERM U 255, Paris, 75006 France Université Paris Descartes Paris 5, Faculte de Medecine, Paris, 75006 France
    Science 313:1960-4. 2006
    ..In situ analysis of tumor-infiltrating immune cells may therefore be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies...
  12. ncbi American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer
    Gary H Lyman
    University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    J Clin Oncol 23:7703-20. 2005
    ..To develop a guideline for the use of sentinel node biopsy (SNB) in early stage breast cancer...
  13. ncbi Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse
    Gaynor J Bates
    Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital Cancer Research UK Molecular Oncology Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
    J Clin Oncol 24:5373-80. 2006
    ..To assess the clinical significance of tumor-infiltrating FOXP3-positive regulatory T cells (TR) in breast cancer patients with long-term follow-up...
  14. pmc VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
    Satoshi Hirakawa
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 201:1089-99. 2005
    ..role in tumor progression and angiogenesis; however, its role in tumor-associated lymphangiogenesis and lymphatic metastasis has remained unclear...
  15. ncbi Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling
    Jacqueline D Shields
    Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne 1015, Switzerland
    Cancer Cell 11:526-38. 2007
    ..Computational modeling revealed that transcellular gradients of CCR7 ligand were created under flow to drive this response. This illustrates how tumor cells may be guided to lymphatics during metastasis...
  16. ncbi Sentinel-node biopsy or nodal observation in melanoma
    Donald L Morton
    Department of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
    N Engl J Med 355:1307-17. 2006
    ..We evaluated the contribution of sentinel-node biopsy to outcomes in patients with newly diagnosed melanoma...
  17. ncbi Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer
    M Morris
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    N Engl J Med 340:1137-43. 1999
    ..Patients were then to receive one or two applications of low-dose-rate intracavitary radiation, with a third cycle of chemotherapy planned for the second intracavitary procedure in the combined-therapy group...
  18. ncbi Effect of preoperative chemotherapy on local-regional disease in women with operable breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-18
    B Fisher
    Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Shadyside Hospital, PA, USA
    J Clin Oncol 15:2483-93. 1997
    ..To determine whether preoperative doxorubicin and cyclophosphamide (AC) permits more lumpectomies to be performed and decreases the incidence of positive nodes in women with primary breast cancer...
  19. ncbi Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
    M Skobe
    Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    Nat Med 7:192-8. 2001
    ..These results establish the occurrence and biological significance of intratumoral lymphangiogenesis in breast cancer and identify VEGF-C as a molecular link between tumor lymphangiogenesis and metastasis...
  20. pmc Gene expression profiling identifies clinically relevant subtypes of prostate cancer
    Jacques Lapointe
    Department of Pathology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 101:811-6. 2004
    ..Our results suggest that prostate tumors can be usefully classified according to their gene expression patterns, and these tumor subtypes may provide a basis for improved prognostication and treatment stratification...
  21. pmc Multivariate analysis of prognostic factors among 2,313 patients with stage III melanoma: comparison of nodal micrometastases versus macrometastases
    Charles M Balch
    Department of Surgery, Johns Hopkins Medical Institutions, 600 N Wolfe St, Osler 624, Baltimore, MD 21287, USA
    J Clin Oncol 28:2452-9. 2010
    ..To determine the survival rates and independent predictors of survival using a contemporary international cohort of patients with stage III melanoma...
  22. pmc Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis
    Sebastian F Schoppmann
    Department of Pathology, University of Vienna Allgemeines Krankenhaus, Austria
    Am J Pathol 161:947-56. 2002
    Formation of lymphatic metastasis is the initial step of generalized spreading of tumor cells and predicts poor clinical prognosis...
  23. ncbi The IASLC lung cancer staging project: a proposal for a new international lymph node map in the forthcoming seventh edition of the TNM classification for lung cancer
    Valerie W Rusch
    Thoracic Surgery Service, Memorial Sloan Kettering Cancer Center, New York City, New York 10065, USA
    J Thorac Oncol 4:568-77. 2009
    ..A method of grouping lymph node stations together into "zones" is also proposed for the purposes of future survival analyses...
  24. ncbi PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis
    Renhai Cao
    Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, 171 77 Stockholm, Sweden
    Cancer Cell 6:333-45. 2004
    ..These data demonstrate that PDGF-BB is an important growth factor contributing to lymphatic metastasis. Thus, blockage of PDGF-induced lymphangiogenesis may provide a novel approach for prevention and treatment ..
  25. ncbi Papillary microcarcinoma of the thyroid-Prognostic significance of lymph node metastasis and multifocality
    Sin Ming Chow
    Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, People s Republic of China
    Cancer 98:31-40. 2003
    ..The rising incidence of PMC among papillary thyroid carcinoma (PTC) necessitates the identification of prognostic factors and the formulation of treatment protocols...
  26. pmc Breast cancer subtypes and response to docetaxel in node-positive breast cancer: use of an immunohistochemical definition in the BCIRG 001 trial
    Judith Hugh
    Department of Lab Medicine and Pathology, University of Alberta Hospital, 8440 112th St, Edmonton, Alberta, Canada T6G 2B7
    J Clin Oncol 27:1168-76. 2009
    ..To investigate the prognostic and predictive significance of subtyping node-positive early breast cancer by immunohistochemistry in a clinical trial of a docetaxel-containing regimen...
  27. ncbi Micrometastases or isolated tumor cells and the outcome of breast cancer
    Maaike de Boer
    Division of Medical Oncology, Maastricht University Medical Center, Maastricht, The Netherlands
    N Engl J Med 361:653-63. 2009
    ..The association of isolated tumor cells and micrometastases in regional lymph nodes with the clinical outcome of breast cancer is unclear...
  28. ncbi Prognostic significance of MMP-9 and TIMP-1 serum and tissue expression in breast cancer
    Zheng Sheng Wu
    Department of Pathology, Anhui Medical University, Hefei, Anhui, People s Republic of China
    Int J Cancer 122:2050-6. 2008
    ..Our findings suggest that MMP-9 and TIMP-1 may further be evaluated as biomarkers for predicting progression and prognosis of breast cancer...
  29. ncbi Locoregional recurrence after sentinel lymph node dissection with or without axillary dissection in patients with sentinel lymph node metastases: the American College of Surgeons Oncology Group Z0011 randomized trial
    Armando E Giuliano
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
    Ann Surg 252:426-32; discussion 432-3. 2010
    ..Few studies have examined the outcome of patients who do not undergo ALND for positive SNs. We now report local and regional recurrence information from the American College of Surgeons Oncology Group Z0011 trial...
  30. ncbi Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
    Mukesh G Harisinghani
    Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 348:2491-9. 2003
    ....
  31. ncbi Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089
    T E Le Voyer
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Clin Oncol 21:2912-9. 2003
    ..To determine the relationship, in patients with adenocarcinoma of the colon, between survival and the number of lymph nodes analyzed from surgical specimens...
  32. ncbi Lymphatic metastasis of breast cancer cells is associated with differential gene expression profiles that predict cancer stem cell-like properties and the ability to survive, establish and grow in a foreign environment
    Terlika S Pandit
    London Regional Cancer Program, London Health Sciences Centre, London, Ontario, Canada
    Int J Oncol 35:297-308. 2009
    ..Differentially expressed genes which reflect these functions provide candidates for investigation as potential targets for therapy directed against early lymphatic metastasis.
  33. ncbi Risk factors for neck nodal metastasis in papillary thyroid microcarcinoma: a study of 1066 patients
    Ling Zhang
    Department of Head and Neck Surgery, Fudan University Cancer Hospital, Department of Oncology, Shanghai Medical College, 270 Dong An Road, Shanghai 200032, People s Republic of China
    J Clin Endocrinol Metab 97:1250-7. 2012
    ..The surgical management of papillary thyroid microcarcinoma (PTMC), especially regarding the necessity of central lymph node dissection, remains controversial...
  34. ncbi Clinicopathological features and prognostic factors of adenocarcinoma of the esophagogastric junction according to Siewert classification: experiences at a single institution in Japan
    Yuichi Hosokawa
    Department of Surgical Oncology, National Cancer Center Hospital East, Kashiwa, Japan
    Ann Surg Oncol 19:677-83. 2012
    ..The aims of this study are to evaluate results of surgery for AEG, to clarify clinicopathological differences according to the Siewert classification, and to define prognostic factors...
  35. pmc A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    James C Yang
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    N Engl J Med 349:427-34. 2003
    ..We conducted a clinical trial to evaluate bevacizumab, a neutralizing antibody against vascular endothelial growth factor, in patients with metastatic renal-cell carcinoma...
  36. ncbi The volume to be irradiated during selective neck irradiation in nasopharyngeal carcinoma: analysis of the spread patterns in lymph nodes by magnetic resonance imaging
    Linglong Tang
    Department of Radiation Oncology, Cancer Center, State Key Laboratory of Oncology in Southern China, Sun Yat Sen University, Guangzhou, People s Republic of China
    Cancer 115:680-8. 2009
    ..In addition, the efficacy of selective neck irradiation was assessed based on the volume irradiated...
  37. pmc Tumor-induced sentinel lymph node lymphangiogenesis and increased lymph flow precede melanoma metastasis
    Maria I Harrell
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Department of Comparative Medicine, University of Washington, 1100 Fairview Ave N, MS C2 023, P O Box 19024, Seattle, WA 98109, USA
    Am J Pathol 170:774-86. 2007
    ..Lymph node lymphangiogenesis and increased lymph flow through tumor-draining lymph nodes may actively promote metastasis via the lymphatics...
  38. pmc Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial
    Kathy S Albain
    Loyola University Chicago Stritch School of Medicine, Cardinal Bernardin Cancer Center, Maywood, IL, USA
    Lancet Oncol 11:55-65. 2010
    ....
  39. ncbi Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival
    J Rubin Grandis
    Department of Otolaryngology, University of Pittsburgh School of Medicine, and University of Pittsburgh Cancer Institute, PA, USA
    J Natl Cancer Inst 90:824-32. 1998
    ....
  40. pmc Lymph node metastasis from 259 papillary thyroid microcarcinomas: frequency, pattern of occurrence and recurrence, and optimal strategy for neck dissection
    Nobuyuki Wada
    First Department of Surgery, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
    Ann Surg 237:399-407. 2003
    ..To determine the frequency and pattern of lymph node metastasis (LNM) from papillary thyroid microcarcinoma (PTMC) and the results of node dissection, and to establish the optimal strategy for neck dissection in these patients...
  41. pmc Staging systems for papillary thyroid carcinoma: a review and comparison
    Brian Hung Hin Lang
    Division of Endocrine Surgery, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong SAR, China
    Ann Surg 245:366-78. 2007
    ..To find out the most predictive staging system for papillary thyroid carcinoma (PTC) currently available in the literature...
  42. ncbi Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels
    Yulong He
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    Cancer Res 65:4739-46. 2005
    ..growth factors vascular endothelial growth factor (VEGF)-C and VEGF-D have been shown to promote lymphatic metastasis by inducing tumor-associated lymphangiogenesis...
  43. ncbi A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer
    Umberto Veronesi
    Division of Senology, European Institute of Oncology, Milan, Italy
    N Engl J Med 349:546-53. 2003
    ..Although numerous studies have shown that the status of the sentinel node is an accurate predictor of the status of the axillary nodes in breast cancer, the efficacy and safety of sentinel-node biopsy require validation...
  44. ncbi Cancer of the esophagus and esophagogastric junction: data-driven staging for the seventh edition of the American Joint Committee on Cancer/International Union Against Cancer Cancer Staging Manuals
    Thomas W Rice
    Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Cancer 116:3763-73. 2010
    ..At the request of the AJCC, worldwide data from 3 continents were assembled to develop data-driven, harmonized esophageal staging for the seventh edition of the AJCC/UICC cancer staging manuals...
  45. ncbi Measurement of residual breast cancer burden to predict survival after neoadjuvant chemotherapy
    W Fraser Symmans
    Department of Pathology, Unit 85, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Clin Oncol 25:4414-22. 2007
    ..To measure residual disease after neoadjuvant chemotherapy in order to improve the prognostic information that can be obtained from evaluating pathologic response...
  46. ncbi Fluorescence navigation with indocyanine green for detecting sentinel lymph nodes in breast cancer
    Toshiyuki Kitai
    Department of Surgery, Nara Social Security Hospital 1 62 Asahicho Yamatokoriyama Nara 639 1013, Japan
    Breast Cancer 12:211-5. 2005
    ..However, intensive training is necessary to obtain a satisfactory detection rate and to avoid false-negative results. This paper presents a novel method using indocyanine green fluorescence imaging to detect sentinel lymph nodes...
  47. ncbi Oral squamous cell carcinoma: review of prognostic and predictive factors
    João Massano
    Faculty of Medicine, University of Coimbra, Coimbra University Hospital, Coimbra, Portugal
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:67-76. 2006
    ....
  48. ncbi Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial
    Joseph Ragaz
    McGill University Health Center, Royal Victoria Hospital, 687 Pine Ave, Montreal, PQ, Canada H3A 1A1
    J Natl Cancer Inst 97:116-26. 2005
    ..We report the analysis of data from the 20-year follow-up...
  49. ncbi Subclinical lymph node metastasis in papillary thyroid microcarcinoma: a study of 551 resections
    Yoon Kyoung So
    Department of Otorhinolaryngology Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Surgery 148:526-31. 2010
    ..We aimed to study clinicopathologic factors associated with subclinical central LNM to be considered for determination of prophylactic CLND...
  50. ncbi A nomogram for predicting the likelihood of additional nodal metastases in breast cancer patients with a positive sentinel node biopsy
    Kimberly J Van Zee
    Departments of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Ann Surg Oncol 10:1140-51. 2003
    ..Accurate estimates of the likelihood of additional disease in the axilla could assist greatly in decision-making regarding further treatment...
  51. ncbi Meeting highlights: updated international expert consensus on the primary therapy of early breast cancer
    Aron Goldhirsch
    International Breast Cancer Study Group, Oncology Institute of Southern Switzerland, Lugano
    J Clin Oncol 21:3357-65. 2003
    ....
  52. ncbi New TNM staging criteria for head and neck tumors
    Brian O'Sullivan
    Wharton Head and Neck Center, Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Canada
    Semin Surg Oncol 21:30-42. 2003
    ..It also provides some guidance regarding optimal source data to facilitate classification in the registry setting. In addition, the need for additional changes in the future is recognized...
  53. ncbi Two positive nodes represent a significant cut-off value for cancer specific survival in patients with node positive prostate cancer. A new proposal based on a two-institution experience on 703 consecutive N+ patients treated with radical prostatectomy, e
    Alberto Briganti
    Department of Urology, Vita Salute University, Milan, Italy
    Eur Urol 55:261-70. 2009
    ..However, node positive (N+) patients share heterogeneous outcomes according to the extent of lymph node invasion (LNI)...
  54. ncbi Standardized uptake value by positron emission tomography/computed tomography as a prognostic variable in metastatic breast cancer
    Patrick G Morris
    Breast Cancer Medicine Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer 118:5454-62. 2012
    ....
  55. ncbi Impact of total lymph node count on staging and survival after gastrectomy for gastric cancer: data from a large US-population database
    David D Smith
    Division of Biostatistics, City of Hope Cancer Center, Duarte, CA, USA
    J Clin Oncol 23:7114-24. 2005
    ..The optimal regional dissection extent during gastrectomy for gastric adenocarcinoma continues to be debated...
  56. ncbi Molecular control of lymphatic metastasis
    Marc G Achen
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050, Melbourne, Australia
    Ann N Y Acad Sci 1131:225-34. 2008
    ..Other signaling molecules that have been reported to promote lymphangiogenesis and/or lymphatic metastasis in cancer include VEGF-A, platelet-derived growth factor-BB, and hepatocyte growth factor...
  57. ncbi Economic evaluation of the 21-gene signature (Oncotype DX) in lymph node-negative/positive, hormone receptor-positive early-stage breast cancer based on Japanese validation study (JBCRG-TR03)
    Masahide Kondo
    Department of Health Care Policy and Management, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8577, Japan
    Breast Cancer Res Treat 127:739-49. 2011
    ..Such a decision can be justifiable as an efficient use of finite resources for health care...
  58. pmc The FLARE intraoperative near-infrared fluorescence imaging system: a first-in-human clinical trial in breast cancer sentinel lymph node mapping
    Susan L Troyan
    Breast Care Center, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Surg Oncol 16:2943-52. 2009
    ..The FLARE imaging system overcomes this major obstacle...
  59. ncbi SPIO-enhanced magnetic resonance imaging for the detection of metastases in sentinel nodes localized by computed tomography lymphography in patients with breast cancer
    Kazuyoshi Motomura
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Ann Surg Oncol 18:3422-9. 2011
    ..The aim of this study was to evaluate MR imaging with superparamagnetic iron oxide (SPIO) enhancement for the detection of metastases in sentinel nodes localized by CT-LG in patients with breast cancer...
  60. ncbi Clinically significant prognostic factors for differentiated thyroid carcinoma: a population-based, nested case-control study
    Catharina Ihre Lundgren
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Cancer 106:524-31. 2006
    ..The objective of the current study was to identify those factors that predict long-term unfavorable prognosis and to evaluate the predictive accuracy of the TNM staging system...
  61. ncbi Proposal for the delineation of the nodal CTV in the node-positive and the post-operative neck
    Vincent Gregoire
    Department of Radiation Oncology, Head and Neck Oncology Program, Universite Catholique de Louvain, Brussels, Belgium
    Radiother Oncol 79:15-20. 2006
    ..These recommendations were applicable for the node-negative and the N1-neck, but were found too restrictive for the node-positive and the post-operative neck...
  62. pmc Stereotactic body radiotherapy for isolated paraaortic lymph node recurrence from colorectal cancer
    Mi Sook Kim
    Department of Radiation Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, 215 4 Gongneung dong, Nowon Gu, Seoul 139 706, South Korea
    World J Gastroenterol 15:6091-5. 2009
    ..To evaluate the efficacy and complications of stereotactic body radiotherapy in localized paraaortic lymph node recurrence from colorectal cancer...
  63. pmc Randomized, double-blind comparison of indocyanine green with or without albumin premixing for near-infrared fluorescence imaging of sentinel lymph nodes in breast cancer patients
    Merlijn Hutteman
    Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands
    Breast Cancer Res Treat 127:163-70. 2011
    ..With these optimized parameters that eliminate the necessity of HSA, larger trials can now be performed to determine patient benefit...
  64. pmc Toward optimization of imaging system and lymphatic tracer for near-infrared fluorescent sentinel lymph node mapping in breast cancer
    J Sven D Mieog
    Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Ann Surg Oncol 18:2483-91. 2011
    ..Near-infrared (NIR) fluorescent sentinel lymph node (SLN) mapping in breast cancer requires optimized imaging systems and lymphatic tracers...
  65. ncbi Role of ultrasound-guided fine-needle aspiration of indeterminate and suspicious axillary lymph nodes in the initial staging of breast carcinoma
    Savitri Krishnamurthy
    Department of Pathology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 95:982-8. 2002
    ..This study was undertaken to determine the diagnostic accuracy of US-guided FNA of indeterminate/suspicious/metastatic-appearing axillary lymph nodes during the initial staging of breast carcinoma...
  66. ncbi Effect of the number of lymph nodes sampled on postoperative survival of lymph node-negative esophageal cancer
    Alexander J Greenstein
    Department of General Surgery, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer 112:1239-46. 2008
    ..In the current study, the association between survival and the number of LNs evaluated was examined in patients who underwent resection of lymph node-negative (American Joint Committee on Cancer [AJCC] TNM stage I-IIA) esophageal cancer...
  67. ncbi Prognostic value of the lymph node ratio in stage III colorectal cancer: a systematic review
    W Ceelen
    Department of Gastrointestinal Surgery, University Hospital, De Pintelaan 185, Ghent, Belgium
    Ann Surg Oncol 17:2847-55. 2010
    ..Recently, the lymph node ratio (LNR), defined as the ratio of the number of positive nodes over the total number of examined nodes, was proposed to stratify outcome in stage III patients...
  68. pmc Multicenter trial of sentinel node biopsy for breast cancer using both technetium sulfur colloid and isosulfan blue dye
    L Tafra
    Breast Center, Anne Arundel Medical Center, Annapolis, Maryland 21401, USA
    Ann Surg 233:51-9. 2001
    ....
  69. ncbi Cervical lymph node metastasis in oral cancer: the importance of even microscopic extracapsular spread
    J A Woolgar
    Oral Pathology Laboratory, Liverpool University Dental Hospital, Pembroke Place, Liverpool L3 5PS, UK
    Oral Oncol 39:130-7. 2003
    ..Extracapsular spread should be incorporated into pathological staging systems. Even microscopic extracapsular spread is of critical importance and must be sought especially in small-volume metastatic disease...
  70. ncbi Discordance of molecular biomarkers associated with epidermal growth factor receptor pathway between primary tumors and lymph node metastasis in non-small cell lung cancer
    Sarah Park
    Department of Medicine, Division of Hematology Oncology, Hangang Sacred Heart Hospital, Hallym University School of Medicine, Seoul, Korea
    J Thorac Oncol 4:809-15. 2009
    ..Given the heterogeneity of NSCLC at the molecular level, this study was conducted to determine the discrepancy in EGFR mutations between primary tumors and the corresponding lymph node metastasis...
  71. ncbi The humoral immune system has a key prognostic impact in node-negative breast cancer
    Marcus Schmidt
    Department of Obstetrics and Gynecology, Medical School, Johannes Gutenberg University, Mainz, Germany
    Cancer Res 68:5405-13. 2008
    ..83; 95% CI, 0.7-0.97). Thus, we could show in three cohorts of untreated, node-negative breast cancer patients that the humoral immune system plays a pivotal role in metastasis-free survival of carcinomas of the breast...
  72. ncbi The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases
    Roderick J Phillips
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, 90024, USA
    Am J Respir Crit Care Med 167:1676-86. 2003
    ..These data suggest that the CXCL12-CXCR4 biological axis is involved in regulating the metastasis of non-small cell lung cancer...
  73. ncbi Intratumor genomic heterogeneity in breast cancer with clonal divergence between primary carcinomas and lymph node metastases
    Lurdes Torres
    Department of Genetics, Portuguese Oncology Institute, Rua Dr Antonio Bernardino de Almeida, Porto, Portugal
    Breast Cancer Res Treat 102:143-55. 2007
    ....
  74. ncbi Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: clinical proof of concept of an integrated functional imaging approach using a multimodal tracer
    Henk G van der Poel
    Department of Urology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Eur Urol 60:826-33. 2011
    ..Integration of molecular imaging and in particular intraoperative image guidance is expected to improve the surgical accuracy of laparoscopic lymph node (LN) dissection...
  75. pmc Loss of human epidermal growth factor receptor 2 (HER2) expression in metastatic sites of HER2-overexpressing primary breast tumors
    Naoki Niikura
    The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1354, Houston, TX 77030, USA
    J Clin Oncol 30:593-9. 2012
    ..We also compared the overall survival durations of patients with HER2-concordant and -discordant tumors...
  76. ncbi Is the benefit of postmastectomy irradiation limited to patients with four or more positive nodes, as recommended in international consensus reports? A subgroup analysis of the DBCG 82 b&c randomized trials
    Marie Overgaard
    Department of Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 82:247-53. 2007
    ..A subgroup analysis of the DBCG 82 b&c trials was performed to evaluate the loco-regional recurrence rate and survival in relation to number of positive nodes...
  77. ncbi CCR7 and CXCR4 as novel biomarkers predicting axillary lymph node metastasis in T1 breast cancer
    Neslihan Cabioglu
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 11:5686-93. 2005
    ..We therefore studied the differential expression of CCR7 and CXCR4, along with that of the biomarker HER2-neu, to evaluate whether these biomarkers could predict axillary lymph node metastasis in breast cancer...
  78. ncbi Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomography
    Didier Lardinois
    Divisions of Thoracic Surgery, University Hospital of Zurich, Zurich, Switzerland
    N Engl J Med 348:2500-7. 2003
    ....
  79. ncbi Second international consensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours
    P B Vermeulen
    Department of Pathology, University Hospital Antwerp, Edegem, Antwerp, Belgium
    Eur J Cancer 38:1564-79. 2002
  80. ncbi 18F-FDG PET and CT/MRI in oral cavity squamous cell carcinoma: a prospective study of 124 patients with histologic correlation
    Shu Hang Ng
    Department of Diagnostic Radiology, Chang Gung Memorial Hospital and Chang Gung University, Taiwan
    J Nucl Med 46:1136-43. 2005
    ..In this prospective study, we evaluated the use of 18F-FDG PET, CT/MRI, and their visual correlation for the identification of primary tumors and cervical nodal metastases of SCC of the oral cavity with histologic correlation...
  81. ncbi The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells
    Jen Liang Su
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    Cancer Cell 9:209-23. 2006
    ..The VEGF-C/Flt-4 axis, through upregulation of contactin-1, may regulate the invasive capacity in different types of cancer cells...
  82. pmc The ratio between metastatic and examined lymph nodes (N ratio) is an independent prognostic factor in gastric cancer regardless of the type of lymphadenectomy: results from an Italian multicentric study in 1853 patients
    Alberto Marchet
    Clinica Chirurgica Generale 2, University of Padova, Padova, Italy
    Ann Surg 245:543-52. 2007
    ....
  83. ncbi Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer
    Monika Schindl
    Institute of Clinical Pathology, Department of Surgery, University of Vienna Medical School, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Clin Cancer Res 8:1831-7. 2002
    ..The aim of this study was to determine the prognostic influence of HIF-1alpha expression in patients with advanced-stage breast cancer, evident by positive lymph nodes...
  84. pmc Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival
    Soheil S Dadras
    Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Am J Pathol 162:1951-60. 2003
    ..Our results reveal tumor lymphangiogenesis as a novel prognostic indicator for the risk of lymph node metastasis in cutaneous melanoma...
  85. ncbi Blocking neuropilin-2 function inhibits tumor cell metastasis
    Maresa Caunt
    Tumor Biology and Angiogenesis, Genentech, Inc, South San Francisco, CA 94080, USA
    Cancer Cell 13:331-42. 2008
    ..Our results demonstrate that Nrp2, which was originally identified as an axon-guidance receptor, is an attractive target for modulating metastasis...
  86. ncbi FOXA1 expression in breast cancer--correlation with luminal subtype A and survival
    Sunil Badve
    Department of Pathology, Indiana University School of Medicine, Indianapolis, USA
    Clin Cancer Res 13:4415-21. 2007
    ..It segregates with genes that characterize the luminal subtypes in DNA microarray analyses. The utility of FOXA1 as a possible independent prognostic factor has not been determined in breast cancers...
  87. ncbi Treatment of non-small cell lung cancer-stage IIIA: ACCP evidence-based clinical practice guidelines (2nd edition)
    Lary A Robinson
    Division of Cardiovascular and Thoracic Surgery, Thoracic Oncology Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, Tampa, FL 33612 9497, USA
    Chest 132:243S-265S. 2007
    ..This review explores the published clinical trials to make treatment recommendations in this controversial subset of lung cancer...
  88. ncbi The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis
    Qihong Huang
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Nat Cell Biol 10:202-10. 2008
    ..Taken together, our findings indicate that miRNAs are involved in tumour migration and invasion, and implicate miR-373 and miR-520c as metastasis-promoting miRNAs...
  89. ncbi Endobronchial ultrasound-guided transbronchial needle aspiration for staging of lung cancer: a systematic review and meta-analysis
    Ping Gu
    Respiratory Department, Shanghai Chest Hospital, Shanghai Jiaotong University School of Medicine, No 214, West Huaihai Road, Shanghai 200030, PR China
    Eur J Cancer 45:1389-96. 2009
    ..The objective of this review was to assess the overall diagnostic accuracy of EBUS-TBNA in detecting metastatic mediastinal lymph node in lung cancer with a meta-analysis...
  90. pmc Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma
    Masahiro Kato
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Breast Cancer Res 5:R144-50. 2003
    ..Recent studies have suggested that CXCR4 is expressed in certain cancer cells and that they use this chemokine receptor efficiently for metastasis formation...
  91. ncbi Lymphatic metastasis in the absence of functional intratumor lymphatics
    Timothy P Padera
    E L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Science 296:1883-6. 2002
    b>Lymphatic metastasis contributes to mortality from solid tumors. Whether metastasizing cancer cells reach lymph nodes via intratumor lymphatic vessels is unknown...
  92. ncbi Periostin promotes invasion and anchorage-independent growth in the metastatic process of head and neck cancer
    Yasusei Kudo
    Department of Oral Maxillofacial Pathobiology, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Center of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima, Japan
    Cancer Res 66:6928-35. 2006
    ..Typically, HNSCC cells show persistent invasion that frequently leads to local recurrence and distant lymphatic metastasis. However, molecular mechanisms associated with the invasion and metastasis of HNSCC remain poorly ..
  93. ncbi Clinical significance of MMP-2 and MMP-9 in patients with oral cancer
    Beena P Patel
    Biochemistry Research Division, Gujarat Cancer and Research Institute, Asarwa, Ahmedabad 380 016, India
    Head Neck 29:564-72. 2007
    ..Therefore, the authors studied plasma and tissue levels of MMP-2 and MMP-9 in oral cancer, the leading malignancy in India...
  94. ncbi Nodal dissection for patients with gastric cancer: a randomised controlled trial
    Chew Wun Wu
    Department of Surgery, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
    Lancet Oncol 7:309-15. 2006
    ..We aimed to do a single-institution randomised trial to compare D1 (ie, level 1) lymphadenectomy with that of D3 (ie, levels 1, 2, and 3) dissection for gastric cancer in terms of overall survival and disease-free survival...
  95. ncbi Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis
    Yulong He
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, Helsinki University Central Hospital, and Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Cancer Res 64:3737-40. 2004
    ..correlated with lymphatic vessel density in the peritumoral area, and despite tumor lymphangiogenesis, lymphatic metastasis failed to occur in gene-targeted vascular endothelial growth factor C(+/-) mice that have hypoplasia of the ..
  96. pmc Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells
    Luana Schito
    Vascular Program, Institute for Cell Engineering, McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 109:E2707-16. 2012
    ..In this study, we show that HIF-1 promotes lymphatic metastasis of breast cancer by direct transactivation of the gene encoding platelet-derived growth factor B (PDGF-B), ..
  97. ncbi Lymph node evaluation and survival after curative resection of colon cancer: systematic review
    George J Chang
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, 1400 Holcombe Blvd, Unit 444, Houston, TX 77030, USA
    J Natl Cancer Inst 99:433-41. 2007
    ..We performed a systematic review of the evidence for the association between lymph node evaluation and oncologic outcomes in patients with colon cancer...
  98. ncbi Risk factors for an adverse outcome in early invasive colorectal carcinoma
    Hideki Ueno
    Department of Surgery I, National Defense Medical College, Saitama, Japan
    Gastroenterology 127:385-94. 2004
    ..Various histologic findings exist for managing patients with malignant polyps. Our goal was to determine the criteria for a conservative approach to patients with locally excised early invasive carcinoma...
  99. pmc PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer
    Jieqiong Liu
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Clin Cancer Res 17:3638-48. 2011
    ..Unlike platelet-derived growth factor-B (PDGF-B), the role of PDGF-D in tumor progression or treatment is largely unknown. To this end, we determined the role of PDGF-D in breast cancer progression, metastasis, and response to chemotherapy...
  100. ncbi CT-based delineation of lymph node levels and related CTVs in the node-negative neck: DAHANCA, EORTC, GORTEC, NCIC,RTOG consensus guidelines
    Vincent Gregoire
    Radiation Oncology Dept and Laboratory of Radiobiology, Universite Catholique de Louvain, St Luc University Hospital, B 1200 Brussels, Belgium
    Radiother Oncol 69:227-36. 2003
    ..and the so-called Rotterdam guidelines from Nowak et al.--emerged from the literature for the delineation of the neck node levels. Detailed examination of these proposals however revealed some important discrepancies...
  101. ncbi Predictive value of tumor thickness for cervical lymph-node involvement in squamous cell carcinoma of the oral cavity: a meta-analysis of reported studies
    Shao Hui Huang
    Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    Cancer 115:1489-97. 2009
    ..To address this question, the authors conducted a meta-analysis...

Research Grants33

  1. Symposium on Cancer Metastasis and Lymphovascular System
    STANLEY LEONG; Fiscal Year: 2004
    ..The critical issue to be defined is the role of the SLN in the process of lymphatic metastasis. Significant advances have been made in the study of molecular events of metastasis through the ..
  2. NF-kB mediated induction of VEGFR-3 and new lymphatic vessels in breast cancer
    Sophia Ran; Fiscal Year: 2013
    ..of vascular endothelial growth factor receptor-3 (VEGFR-3), the main receptor driving lymphangiogenesis and lymphatic metastasis. Evidence is also presented that in lymphatic endothelial cells (LECs) VEGFR-3 expression might be ..
  3. Physiologic Study of Lymphatic Metastasis
    VICENTE ANDRES RESTO; Fiscal Year: 2013
    ..predictive of mortality, yet, to date, we possess little biologic understanding ofthe processes directing lymphatic metastasis, and no understanding of the dynamic interaction between tumors and the lymph node microenvironment...
  4. Functional Imaging of the Metastatic Phenotype
    Zaver M Bhujwalla; Fiscal Year: 2013
    ..continue to be to understand prostate cancer invasion and metastasis with a focus, in this application, on lymphatic metastasis and malignant ascites...
  5. VEGFs in tumor lymphatic metastasis
    HAROLD FISHER DVORAK; Fiscal Year: 2012
    ..This application is focused on understanding the mechanisms that these factors use to induce lymphangiogenesis and metastasis in melanoma, as well as how these mechanisms impact emerging cancer therapies. ..
  6. The Six1/Eya Transcriptional complex as a mediator of lymphangiogenesis and lymph
    Heide L Ford; Fiscal Year: 2013
    ..The ability of Six1 to activate VEGF-C and stimulate lymphatic metastasis is dependent on its interaction with the Eya2 phosphatase co-factor, and on the enzymatic activity of Eya2...
  7. 4D Microfluidic Platforms for Targeting Breast Cancer:Lymphatic Interactions
    Bonnie F Sloane; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Abstract Lymphatic metastasis is the predominant route of the initial spread of breast cancer cells and their presence in regional lymph nodes is the single most clinically important negative ..
  8. Characterizing lymphatic micrometastases: prognostic and therapeutic implications
    Timothy P Padera; Fiscal Year: 2011
    ..characterize the biological triggers for growth from individually seeded cancer cells, determine whether lymphatic metastasis are clonal and investigate whether lymph node metastases can further disseminate...
  9. Mechanisms of VEGF-A regulated tumor lymphangiogenesis
    Sophia Ran; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Lymphatic metastasis is the main dissemination pathway in many solid tumors. The prerequisite for this process is generation of new lymphatic vessels accessible to tumor cells...
  10. Slit-Robo Signaling in Tumor Growth and Metastasis
    Jian Guo Geng; Fiscal Year: 2013
    ..metastasis of tumors, we will investigate (1) the effect of Slit-Robo signaling in lymphangiogenesis and lymphatic metastasis, the pathological role of Slit2 in tumor angiogenesis and growth and (2) the effect of Slit-Robo signaling ..
  11. Imaging Lymphatic Clearance in Tumor Metastasis
    Zaver Bhujwalla; Fiscal Year: 2003
    ..metastasis is the most powerful index of prognosis, particularly in breast cancer, mechanisms underlying lymphatic metastasis have largely been overshadowed by the focus on angiogenesis and vascular dissemination...
  12. Photodynamic Therapy of Disseminated Peritoneal Tumor Using New Photosensitizers
    J Wharton; Fiscal Year: 2009
    ..but is also responsible for tumor recurrence in patients with resectable tumors that lack hematogenous or lymphatic metastasis due to the presence of residual or seeded (from surgery) disease cells...
  13. BIOLOGY OF TUMOR ANGIOGENESIS, INVASION AND METASTASIS
    Rakesh Jain; Fiscal Year: 2004
    ..critical aspects of tumor metastasis: angiogenesis, invasion, hematogenous metastasis and lymphangiogenesis lymphatic metastasis. In the first year we will achieve several significant milestones: i) critically test the longstanding but ..
  14. LYMPHATIC METASTASIS OF MELANOMA TUMOR CELLS
    Daniel Ramos; Fiscal Year: 1992
    ..This is especially relevant to head and neck cancers in which lymphatic metastasis is the primary mechanism of tumor dissemination...
  15. PET-guided Intervention in Lymphatic Metastasis of Prostate Cancer
    Lily Wu; Fiscal Year: 2008
    ..The tumoral lymphangiogenesis and lymphatic metastasis will be induced in the PTEN-null murine prostate cancer model...
  16. MEDICAL IGNORANCE (QQQ) COLLABORATORY K12 CURRICULUM
    Marlys Witte; Fiscal Year: 2005
    ....
  17. A Genetic Screening Policy Model for Colorectal Cancer
    Scott Ramsey; Fiscal Year: 2006
    ..The model will incorporate QOL information from Aim 2, along with family history, clinical, and screening information from the Seattle CFR. ..
  18. COST EFFECTIVENESS OF GENETIC SCREENING FOR COLON CANCER
    Scott Ramsey; Fiscal Year: 2002
    ....
  19. Phase II Trial of Tetrathiomolybdate in Prostate Cancer
    David Smith; Fiscal Year: 2002
    ..The levels of these growth factors/cytokines will then be correlated with the degree of copper depletion, PSA level and response to therapy. ..
  20. Massage Therapy for Breast Cancer-related Lymphedema
    Michael Bernas; Fiscal Year: 2003
    ..abstract_text> ..
  21. Role of BMDCs in Solid Tumor Growth and Relapse
    Rakesh K Jain; Fiscal Year: 2010
    ..Furthermore, our results will offer strategies for the inhibition of tumor relapse after radiotherapy by targeting molecular pathways that are critical for both angiogenesis and myeloid BMDC recruitment. ..
  22. DNA Markers As Surrogates:Melanoma Patient Response
    Dave Hoon; Fiscal Year: 2008
    ..The R33 phase will focus on validating the PGMs and determining their clinical utility in an ongoing prospective multicenter Phase II BC and maintenance Biotherapy trial for AJCC stage IV melanoma patients. ..
  23. Integrative Biology of Tumor Metastasis
    Rakesh Jain; Fiscal Year: 2009
    ..Finally, we have the resources and the clinical collaborators in place to initiate a clinical trial based on our findings, as attested by our ongoing trial using a VEGF-specific antibody. ..
  24. Hypoxia-Inducible Factor 1 and Oxygen Homeostasis
    Gregg Semenza; Fiscal Year: 2009
    ....
  25. Anti-Angiogenesis/Drugs in Tumors--Bench /Bedside & Back
    Rakesh Jain; Fiscal Year: 2005
    ..Attendance at this conference will provide an excellent opportunity for young investigators working on cancer to educate and familiarize themselves with the field of angiogenesis and the complexities of the system. ..
  26. International Conferences of the Society for Integrative Oncology
    Peter Johnstone; Fiscal Year: 2008
    ..This year, satellite sessions will be held to discuss specific aspects of Acupuncture, Music Therapy, and Massage Therapy in cancer patients. [unreadable] [unreadable] [unreadable] [unreadable]..
  27. EXPRESSION OF HUMAN ERYTHROPOIETIN GENE
    Gregg Semenza; Fiscal Year: 2002
    ..abstract_text> ..
  28. Conference on Angiogenesis in Cancer and Other Diseases
    Rakesh Jain; Fiscal Year: 2002
    ..The meeting's synthesis of available information will be particularly thought-provoking for students and post- doctoral fellows. ..
  29. Targeted Enzymes for Prodrug Therapy
    David Krag; Fiscal Year: 2007
    ..Successful completion of these experiments will result in demonstration of novel targeted effector molecules that bind selectively to tumors and activate cytotoxic prodrugs. ..
  30. In Vivo Selection of Ligands for Targeted Therapy
    David Krag; Fiscal Year: 2003
    ..Successful completion of this clinical study will result in demonstration of a satisfactory safety profile and short peptides that bind selectively to tumor tissue. ..
  31. Regulation of Proinflammatory Signaling Pathways in CFTR
    HARVEY BRUCE POLLARD; Fiscal Year: 2010
    ..The proposal is both unique and innovative by directing the investigation to the biology and chemistry of the IL-8 promoter in CF lung epithelial cells, both in vitro and in vivo. ..
  32. Very-High-Frequency Ultrasound Imaging With Coded Signals and Annular Arrays
    Jonathan Mamou; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  33. Oncology Clinical Trial Accrual Study
    ANNEKE SCHROEN; Fiscal Year: 2009
    ....