neoplasm invasiveness

Summary

Summary: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.

Top Publications

  1. ncbi The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    Philip A Gregory
    Hanson Institute and Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
    Nat Cell Biol 10:593-601. 2008
  2. pmc Tumor metastasis: molecular insights and evolving paradigms
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 147:275-92. 2011
  3. ncbi Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    Li Ma
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 449:682-8. 2007
  4. ncbi Involvement of chemokine receptors in breast cancer metastasis
    A Muller
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 410:50-6. 2001
  5. ncbi MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    Fanyin Meng
    Department of Internal Medicine, Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, Texas, USA
    Gastroenterology 133:647-58. 2007
  6. ncbi A perspective on cancer cell metastasis
    Christine L Chaffer
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 331:1559-64. 2011
  7. ncbi Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    Hector Peinado
    Departamento de Bioquimica, Facultad de Medicina, Universidad Autonoma de Madrid UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Rev Cancer 7:415-28. 2007
  8. ncbi Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 117:927-39. 2004
  9. ncbi Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    Antoine E Karnoub
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 449:557-63. 2007
  10. pmc Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    Marta Pàez-Ribes
    Translational Research Laboratory, Catalan Institute of Oncology, IDIBELL, 08907 L Hospitalet de Llobregat, Spain
    Cancer Cell 15:220-31. 2009

Detail Information

Publications320 found, 100 shown here

  1. ncbi The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    Philip A Gregory
    Hanson Institute and Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
    Nat Cell Biol 10:593-601. 2008
    ..Expression of the miR-200 family was also lost in regions of metaplastic breast cancer specimens lacking E-cadherin. These data suggest that downregulation of the microRNAs may be an important step in tumour progression...
  2. pmc Tumor metastasis: molecular insights and evolving paradigms
    Scott Valastyan
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 147:275-92. 2011
    ..Recent advances provide provocative insights into these cell-biological and molecular changes, which have implications regarding the steps of the invasion-metastasis cascade that appear amenable to therapeutic targeting...
  3. ncbi Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    Li Ma
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 449:682-8. 2007
    ....
  4. ncbi Involvement of chemokine receptors in breast cancer metastasis
    A Muller
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 410:50-6. 2001
    ..Our findings indicate that chemokines and their receptors have a critical role in determining the metastatic destination of tumour cells...
  5. ncbi MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    Fanyin Meng
    Department of Internal Medicine, Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, Texas, USA
    Gastroenterology 133:647-58. 2007
    ..Although a role for aberrant miRNA expression in cancer has been postulated, the pathophysiologic role and relevance of aberrantly expressed miRNA to tumor biology has not been established...
  6. ncbi A perspective on cancer cell metastasis
    Christine L Chaffer
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 331:1559-64. 2011
    ....
  7. ncbi Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    Hector Peinado
    Departamento de Bioquimica, Facultad de Medicina, Universidad Autonoma de Madrid UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Rev Cancer 7:415-28. 2007
    ....
  8. ncbi Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 117:927-39. 2004
    ..These results establish a mechanistic link between Twist, EMT, and tumor metastasis...
  9. ncbi Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    Antoine E Karnoub
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 449:557-63. 2007
    ..Collectively, these data demonstrate that the tumour microenvironment facilitates metastatic spread by eliciting reversible changes in the phenotype of cancer cells...
  10. pmc Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    Marta Pàez-Ribes
    Translational Research Laboratory, Catalan Institute of Oncology, IDIBELL, 08907 L Hospitalet de Llobregat, Spain
    Cancer Cell 15:220-31. 2009
    ....
  11. ncbi The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    A Cano
    Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Cell Biol 2:76-83. 2000
    ..Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs...
  12. ncbi Malignant astrocytic glioma: genetics, biology, and paths to treatment
    Frank B Furnari
    Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California 92093, USA
    Genes Dev 21:2683-710. 2007
    ..This progress is fueling new opportunities for understanding the fundamental basis for development of this devastating disease and also novel therapies that, for the first time, portend meaningful clinical responses...
  13. ncbi Cancer invasion and the microenvironment: plasticity and reciprocity
    Peter Friedl
    Department of Cell Biology, Radboud University Nijmegen Medical Centre, 6500 HC Nijmegen, The Netherlands
    Cell 147:992-1009. 2011
    ..The resulting "plasticity" contributes to the generation of diverse cancer invasion routes and programs, enhanced tumor heterogeneity, and ultimately sustained metastatic dissemination...
  14. ncbi Matrix metalloproteinases and tumor metastasis
    Elena I Deryugina
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cancer Metastasis Rev 25:9-34. 2006
    ..This dual function of individual MMPs in metastasis has become a major focus of this review...
  15. ncbi MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
    I A Asangani
    Department of Experimental Surgery and Molecular Oncology of Solid Tumors, Medical Faculty Mannheim, University of Heidelberg, Germany
    Oncogene 27:2128-36. 2008
    ..This is the first study to show that Pdcd4 is negatively regulated by miR-21. Furthermore, it is the first report to demonstrate that miR-21 induces invasion/intravasation/metastasis...
  16. pmc The epithelial-mesenchymal transition: new insights in signaling, development, and disease
    Jonathan M Lee
    Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
    J Cell Biol 172:973-81. 2006
    ..E.W. Thompson, and D.F. Newgreen. 2005. Cancer Res. 65:5996-6000; Thompson, E.W., D.F. Newgreen, and D. Tarin. 2005. Cancer Res. 65:5991-5995)...
  17. ncbi Tumor metastasis: mechanistic insights and clinical challenges
    Patricia S Steeg
    Women s Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute Building 37, Room 1122, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 12:895-904. 2006
  18. pmc A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    Ulrike Burk
    Department of Visceral Surgery, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    EMBO Rep 9:582-9. 2008
    ..Alternatively, depending on the environmental trigger, this loop might switch and induce epithelial differentiation, and thus explain the strong intratumorous heterogeneity observed in many human cancers...
  19. pmc miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
    Li Ma
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Cell Biol 12:247-56. 2010
    ..These findings uncover a regulatory and signalling pathway involving a metastasis-promoting miRNA that is predicted to directly target expression of the key metastasis-suppressing protein E-cadherin...
  20. ncbi EMT, the cytoskeleton, and cancer cell invasion
    Mahmut Yilmaz
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland
    Cancer Metastasis Rev 28:15-33. 2009
    ..In this review, we have summarized recent novel insights into the molecular processes and players underlying EMT on one side and the formation of invasive membrane protrusions on the other side...
  21. pmc The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function
    Danielle A Murphy
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Mol Cell Biol 12:413-26. 2011
    ..Recently, progress has been made in our understanding of the regulatory and functional aspects of podosome and invadopodium biology and their role in human disease...
  22. pmc EMT and dissemination precede pancreatic tumor formation
    Andrew D Rhim
    Gastroenterology Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell 148:349-61. 2012
    ..These results provide insight into the earliest events of cellular invasion in situ and suggest that inflammation enhances cancer progression in part by facilitating EMT and entry into the circulation...
  23. ncbi Rho GTPases in cancer cell biology
    Francisco M Vega
    Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, London SE1 1UL, UK
    FEBS Lett 582:2093-101. 2008
    ..Here, we discuss how Rho GTPases could contribute to different steps of cancer progression, including proliferation, survival, invasion and metastasis...
  24. pmc p53 and its mutants in tumor cell migration and invasion
    Patricia A J Muller
    Beatson Institute for Cancer Research, Glasgow G61 1BD, Scotland, UK
    J Cell Biol 192:209-18. 2011
    ..Moreover, recent data suggests that expression of mutant p53 is not the equivalent of p53 loss, and that mutant p53s can acquire new functions to drive cell migration, invasion, and metastasis, in part by interfering with p63 function...
  25. ncbi The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
    J Comijn
    Molecular Cell Biology Unit, Department of Molecular Biology, VIB Ghent University, B 9000, Ghent, Belgium
    Mol Cell 7:1267-78. 2001
    ..SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors...
  26. ncbi Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways
    Lionel Larue
    Developmental Genetics of Melanocytes, UMR 146, CNRS, Institut Curie, Centre Universitaire, Orsay, France
    Oncogene 24:7443-54. 2005
    ..Interactions between PI3K/AKT and other EMT-inducing pathways are presented, along with a discussion of the therapeutic implications of modulating EMT in order to achieve cancer control...
  27. ncbi Cancer and the chemokine network
    Fran Balkwill
    Cancer Research UK Translational Oncology Laboratory, Barts and The London, Queen Mary s Medical School, Charterhouse Square, London EC1M 6BQ, UK
    Nat Rev Cancer 4:540-50. 2004
  28. ncbi Role of integrins in cell invasion and migration
    John D Hood
    Scripps Research Institute, Departments of Immunology and Vascular Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Cancer 2:91-100. 2002
    ..Integrins are crucial for cell invasion and migration, not only for physically tethering cells to the matrix, but also for sending and receiving molecular signals that regulate these processes...
  29. pmc MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA
    William Kong
    Departments of Molecular Oncology, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, SRB3, Tampa, FL 33612, USA
    Mol Cell Biol 28:6773-84. 2008
    ..These data suggest that miR-155 may play an important role in TGF-beta-induced EMT and cell migration and invasion by targeting RhoA and indicate that it is a potential therapeutic target for breast cancer intervention...
  30. ncbi Cell adhesion and signalling by cadherins and Ig-CAMs in cancer
    Ugo Cavallaro
    Institute of Biochemistry and Genetics, Department of Clincal Biological Sciences, University of Basel Switzerland
    Nat Rev Cancer 4:118-32. 2004
  31. ncbi Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion
    Shuh Narumiya
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, 606 8501, Japan
    Cancer Metastasis Rev 28:65-76. 2009
    ..Thus, Rho mediates various phenotypes of malignant transformation by Ras and Src through its effectors, ROCK and mDia...
  32. pmc The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression
    Paraic A Kenny
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Mol Oncol 1:84-96. 2007
    ..We further demonstrate that consistent differences in genes encoding signal transduction proteins emerge when even tumor cells are cultured in 3D microenvironments...
  33. ncbi Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma
    Torsten O Nielsen
    Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver Hospital and British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Clin Cancer Res 10:5367-74. 2004
    ..Currently, there exist clinical assays that identify ER+/luminal and HER2-overexpressing tumors, and we sought to develop a clinical assay for breast basal-like tumors...
  34. ncbi Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection
    Qiang Gao
    Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, the Chinese Ministry of Education, Shanghai, People s Republic of China
    J Clin Oncol 25:2586-93. 2007
    ..To investigate the prognostic value of tumor-infiltrating lymphocytes (TILs), especially regulatory T cells (Tregs), in hepatocellular carcinoma (HCC) patients after resection...
  35. pmc Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression
    Douglas S Micalizzi
    Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Mammary Gland Biol Neoplasia 15:117-34. 2010
    ..This review focuses on the parallels between epithelial plasticity/EMT in the mammary gland and other organs during development, and on a selection of developmental EMT regulators that are misexpressed specifically during breast cancer...
  36. ncbi Metastasis: a question of life or death
    Patrick Mehlen
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS FRE2870, Centre Leon Berard, Universite Claude Bernard Lyon 1, 69008 Lyon, France
    Nat Rev Cancer 6:449-58. 2006
    ..Here we stress that the inhibition of cell death, apart from its extensively described function in primary tumour development, is a crucial characteristic of metastatic cancer cells...
  37. ncbi Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression
    Honor Hugo
    Embryology Laboratory, Murdoch Children s Research Institute, The Royal Children s Hospital, Victoria, Australia
    J Cell Physiol 213:374-83. 2007
    ..Finally, perspectives from a clinical and translational viewpoint are discussed...
  38. pmc Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion
    Yadi Wu
    Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Cancer Cell 15:416-28. 2009
    ..Our study provides a plausible mechanism for inflammation-induced metastasis...
  39. ncbi EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder, the 2011 update
    Marko Babjuk
    Department of Urology, Hospital Motol, Second Faculty of Medicine, Charles University, Praha, Czech Republic
    Eur Urol 59:997-1008. 2011
    ..To present the 2011 European Association of Urology (EAU) guidelines on non-muscle-invasive bladder cancer (NMIBC)...
  40. ncbi Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
    Cedric Gaggioli
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Nat Cell Biol 9:1392-400. 2007
    ..Instead, carcinoma cells use Cdc42 and MRCK (myotonic dystrophy kinase-related CDC42-binding protein kinases) mediated regulation of MLC to follow the tracks generated by fibroblasts...
  41. ncbi Why do cancers have high aerobic glycolysis?
    Robert A Gatenby
    Department of Radiology, University of Arizona, Tucson, Arizona 85721, USA
    Nat Rev Cancer 4:891-9. 2004
    ..Subsequent cell populations with upregulated glycolysis and acid resistance have a powerful growth advantage, which promotes unconstrained proliferation and invasion...
  42. pmc Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis
    G M Clifford
    International Agency for Research on Cancer, 150, cours Albert Thomas, 69008 Lyon, France
    Br J Cancer 88:63-73. 2003
    ..A majority of ICC was associated with HPV16 or 18 in all regions, but approximately a quarter of all ICC cases were associated with one of 16 other HPV types, their distribution varying by region...
  43. pmc Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    Q Yu
    Molecular Pathology Unit, Massachusetts General Hospital, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02129 USA
    Genes Dev 14:163-76. 2000
    ..These observations suggest that coordinated CD44, MMP-9, and TGF-beta function may provide a physiological mechanism of tissue remodeling that can be adopted by malignant cells to promote tumor growth and invasion...
  44. pmc MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor
    Jun Tie
    State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi an, Shaanxi, China
    PLoS Genet 6:e1000879. 2010
    ..Taken together, our results describe a Slit-miR-218-Robo1 regulatory circuit whose disruption may contribute to GC metastasis. Targeting miR-218 may provide a strategy for blocking tumor metastasis...
  45. ncbi Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis
    Jason J Christiansen
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cancer Res 66:8319-26. 2006
    ..We suggest that these mechanisms can manifest in a series of independent and reversible steps and that EMT represents just one mechanism in the global metastatic carcinoma development process...
  46. ncbi Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma
    Ashani T Weeraratna
    National Human Genome Research Institute, Cancer Genetics Branch, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Cell 1:279-88. 2002
    ..Furthermore, Wnt5a expression in human melanoma biopsies directly correlated to increasing tumor grade. These observations support a role for Wnt5a in human melanoma progression...
  47. ncbi E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer
    Otto Schmalhofer
    Department of Visceral Surgery, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany
    Cancer Metastasis Rev 28:151-66. 2009
    ....
  48. ncbi New signals from the invasive front
    Gerhard Christofori
    Department of Clinical Biological Sciences, Center of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Nature 441:444-50. 2006
    ....
  49. ncbi Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy
    Christopher M Overall
    University of British Columbia Centre for Blood Research, CBCRA Program in Breast Cancer Metastasis, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Nat Rev Cancer 6:227-39. 2006
    ..These effects might partially account for the failure of MMP inhibitors in clinical trials. What are the major challenges in MMP target validation and MMP-inhibitor-drug development?..
  50. pmc Collagen reorganization at the tumor-stromal interface facilitates local invasion
    Paolo P Provenzano
    Department of Pharmacology, University of Wisconsin, Madison, WI, USA
    BMC Med 4:38. 2006
    ....
  51. pmc miR-146a suppresses invasion of pancreatic cancer cells
    Yiwei Li
    Departments of Pathology and Internal Medicine, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Cancer Res 70:1486-95. 2010
    ..Our findings reveal DIM and isoflavone as nontoxic activators of a miRNA that can block pancreatic cancer cell invasion and metastasis, offering starting points to design novel anticancer agents...
  52. pmc Mechanics, malignancy, and metastasis: the force journey of a tumor cell
    Sanjay Kumar
    Department of Bioengineering, University of California, Berkeley, USA
    Cancer Metastasis Rev 28:113-27. 2009
    ....
  53. ncbi Macrophages: obligate partners for tumor cell migration, invasion, and metastasis
    John Condeelis
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell 124:263-6. 2006
    ..Thus, macrophages are at the center of the invasion microenvironment and are an important drug target for cancer therapy...
  54. ncbi Cost of migration: invasion of malignant gliomas and implications for treatment
    A Giese
    Department of Neurosurgery, University Hospital Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Clin Oncol 21:1624-36. 2003
    ....
  55. ncbi Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion
    Katarina Wolf
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Nat Cell Biol 9:893-904. 2007
    ..Thus, invasive migration and proteolytic ECM remodelling are interdependent processes that control tissue micropatterning and macropatterning and, consequently, individual and collective cell migration...
  56. ncbi Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion
    Manabu Kurayoshi
    Department of Biochemistry, Hiroshima University, Hiroshima, Japan
    Cancer Res 66:10439-48. 2006
    ..These results suggest that Wnt-5a stimulates cell migration by regulating focal adhesion complexes and that Wnt-5a is not only a prognostic factor but also a good therapeutic target for gastric cancer...
  57. ncbi The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors
    Victoria Bolós
    Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier, 4, 28029 Madrid, Spain
    J Cell Sci 116:499-511. 2003
    ....
  58. pmc MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators
    Galina Gabriely
    Center of Neurologic Diseases, Brigham and Women s Hospital, 4 Blackfan Circle, HIM 758, Boston, MA 02115, USA
    Mol Cell Biol 28:5369-80. 2008
    ....
  59. pmc Notch signaling mediates hypoxia-induced tumor cell migration and invasion
    Cecilia Sahlgren
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:6392-7. 2008
    ..In sum, these data demonstrate a complex integration of the hypoxia and Notch signaling pathways in regulation of EMT and open up perspectives for pharmacological intervention with hypoxiainduced EMT and cell invasiveness in tumors...
  60. pmc Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma
    R Tung-Ping Poon
    Centre of Liver Diseases, Department of Surgery, The University of Hong Kong Medical Centre, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Ann Surg 232:10-24. 2000
    ..To evaluate the current knowledge on the risk factors for recurrence, efficacy of adjuvant therapy in preventing recurrence, and the optimal management of recurrence after resection of hepatocellular carcinoma (HCC)...
  61. pmc Repression of E-cadherin by the polycomb group protein EZH2 in cancer
    Q Cao
    Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    Oncogene 27:7274-84. 2008
    ..Taken together, these observations provide a novel mechanism of E-cadherin regulation and establish a functional link between dysregulation of EZH2 and repression of E-cadherin during cancer progression...
  62. ncbi Extracellular matrix remodelling: the role of matrix metalloproteinases
    Ivan Stamenkovic
    Experimental Pathology Division, Institut Universitaire de Pathologie, Universite de Lausanne, 25 Rue du Bagnon, CH 1011 Lausanne, Switzerland
    J Pathol 200:448-64. 2003
    ..This review summarizes some of the recent discoveries that have shed new light on the role of MMPs in physiology and disease...
  63. ncbi Regulation of matrix metalloproteinase expression in tumor invasion
    J Westermarck
    MediCity Research Laboratory, Department of Medical Biochemistry, University of Turku, Finland
    FASEB J 13:781-92. 1999
    ....
  64. pmc Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
    T Brabletz
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Proc Natl Acad Sci U S A 98:10356-61. 2001
    ....
  65. pmc IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
    Pasquale Sansone
    Center for Applied Biomedical Research, St Orsola Malpighi University Hospital, Department of Pharmacology and Toxicology, University of Bologna, Bologna, Italy
    J Clin Invest 117:3988-4002. 2007
    ..In conclusion, these data support the hypothesis that IL-6 induces malignant features in Notch-3-expressing stem/progenitor cells from human ductal breast carcinoma and normal mammary gland...
  66. pmc Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited
    Farideh Sabeh
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 185:11-9. 2009
    ....
  67. ncbi Metastasis mechanisms
    Thomas R Geiger
    Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Biochim Biophys Acta 1796:293-308. 2009
    ..A better understanding of the molecular processes underlying metastasis will conceivably present us with novel targets for therapeutic intervention...
  68. ncbi Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel
    George Z Cheng
    Department of Microbiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Cancer Res 67:1979-87. 2007
    ..Our study identifies Twist as a positive transcriptional regulator of AKT2 expression, and Twist-AKT2 signaling is involved in promoting invasive ability and survival of breast cancer cells...
  69. ncbi Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments
    Patrick T Caswell
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Dev Cell 13:496-510. 2007
    ..These data indicate that Rab25 contributes to tumor progression by directing the localization of integrin-recycling vesicles and thereby enhancing the ability of tumor cells to invade the extracellular matrix...
  70. pmc Tumor suppressive microRNA-1285 regulates novel molecular targets: aberrant expression and functional significance in renal cell carcinoma
    Hiedo Hidaka
    Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Oncotarget 3:44-57. 2012
    ..Thus, miR-1285 modulates a novel molecular target and provides new insights into potential mechanisms of RCC oncogenesis...
  71. pmc Suppression of cell growth and invasion by miR-205 in breast cancer
    Hailong Wu
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, 825 N Rutledge, PO Box 19626, Springfield, IL 62794, USA
    Cell Res 19:439-48. 2009
    ..Together, these results suggest that miR-205 is a tumor suppressor in breast cancer...
  72. ncbi MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance
    Taiki Moriyama
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Mol Cancer Ther 8:1067-74. 2009
    ..These data suggest that miR-21 expression is increased in pancreatic cancer cells and that miR-21 contributes to the cell proliferation, invasion, and chemoresistance of pancreatic cancer...
  73. pmc Dynamin participates in focal extracellular matrix degradation by invasive cells
    Massimiliano Baldassarre
    Department of Cell Biology and Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, S Maria Imbaro Chieti, 66030 Italy
    Mol Biol Cell 14:1074-84. 2003
    ..Dyn2 seemed to be concentrated at invadopodia...
  74. ncbi Hypoxia-driven selection of the metastatic phenotype
    Richard Sullivan
    Department of Anatomy and Cell Biology, Queen s University, Kingston, ON K7L 3N6, Canada
    Cancer Metastasis Rev 26:319-31. 2007
    ..Through regulation of these critical molecular targets, hypoxia promotes each step of the metastatic cascade and selects tumor cell populations that are able to escape the unfavorable microenvironment of the primary tumor...
  75. ncbi MicroRNA-101 is down-regulated in gastric cancer and involved in cell migration and invasion
    Hui ju Wang
    Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, 310014 Zhejiang, China
    Eur J Cancer 46:2295-303. 2010
    ..Collectively, these results suggest that miR-101 may function as a tumour suppressor in gastric cancer, as it has an inhibitory role not only in cellular proliferation, migration and invasion in vitro, but also in tumour growth in vivo...
  76. ncbi Systemic spread is an early step in breast cancer
    Yves Hüsemann
    Department of Pathology, Division of Oncogenomics, University of Regensburg, Regensburg 93053, Germany
    Cancer Cell 13:58-68. 2008
    ..Therefore, release from dormancy of early-disseminated cancer cells may frequently account for metachronous metastasis...
  77. ncbi miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells
    Na Li
    Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, PR China
    Cancer Lett 275:44-53. 2009
    ..Taken together, these results provide evidence to show the suppression role of miR-34a in tumor migration and invasion through modulation of the c-Met signaling pathway...
  78. ncbi Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
    Anuradha Budhu
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Cell 10:99-111. 2006
    ..We suggest that a predominant humoral cytokine profile occurs in the metastatic liver milieu and that a shift toward anti-inflammatory/immune-suppressive responses may promote HCC metastases...
  79. pmc Invasive prostate cancer cells are tumor initiating cells that have a stem cell-like genomic signature
    George J Klarmann
    Cancer Stem Cell Section, Laboratory of Cancer Prevention, SAIC Frederick Inc, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Clin Exp Metastasis 26:433-46. 2009
    ..Our data strongly suggest that basement membrane invasion, an early and necessary step in metastasis development, is mediated by these potential cancer stem cells...
  80. pmc A cancer cell metalloprotease triad regulates the basement membrane transmigration program
    Kevin Hotary
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 20:2673-86. 2006
    ..These studies characterize the first series of gene products capable of orchestrating the entire BM remodeling program that distinguishes the carcinomatous phenotype...
  81. pmc Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget
    Inti Zlobec
    Institute for Pathology, University Hospital Basel, Schoenbeinstrasse 40, Basel, Switzerland
    Oncotarget 1:651-61. 2010
    ..The aim of this review is to summarize the evidence supporting the implementation of tumor budding into diagnostic pathology and patient management and additionally to illustrate its worthiness as a potential therapeutic target...
  82. ncbi Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells
    Chie Kudo-Saito
    Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160 8582, Japan
    Cancer Cell 15:195-206. 2009
    ..These results suggest that inhibition of Snail-induced EMT could simultaneously suppress both tumor metastasis and immunosuppression in cancer patients...
  83. pmc miR-200 regulates PDGF-D-mediated epithelial-mesenchymal transition, adhesion, and invasion of prostate cancer cells
    Dejuan Kong
    Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Stem Cells 27:1712-21. 2009
    ....
  84. ncbi Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia
    Renaud Poincloux
    CNRS, UMR144, Membrane and Cytoskeleton Dynamics, and Institut Curie, Paris, France
    J Cell Sci 122:3015-24. 2009
    ..Furthermore, the recent identification of cellular components that control delivery of MT1-MMP to invadopodia brings new insight into mechanisms of cancer-cell invasion and reveals potential pharmacological targets...
  85. ncbi MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells
    Tao Li
    Department of Urology, Ren Ji Hospital, Shanghai Jiao Tong University, China
    Biochem Biophys Res Commun 383:280-5. 2009
    ..Gene therapy using miR-21 inhibition strategy may therefore be useful as a prostate cancer therapy...
  86. ncbi A multigenic program mediating breast cancer metastasis to bone
    Yibin Kang
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer Cell 3:537-49. 2003
    ....
  87. pmc Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets
    Dominique B Hoelzinger
    Translational Genomics Research Institute TGen, Phoenix, AZ 85004, USA
    Neoplasia 7:7-16. 2005
    ..Gene products supporting invasion may be novel targets for manipulation of brain tumor behavior with consequences on treatment outcome...
  88. ncbi Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment
    Dominique B Hoelzinger
    Cancer and Cell Biology Division, Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, AZ 85004, USA
    J Natl Cancer Inst 99:1583-93. 2007
    ..We suggest that cells in the normal brain parenchyma be considered as potential targets for adjuvant therapies to control glioma growth because such cells are less likely to develop resistance than glioma cells...
  89. pmc IAP regulation of metastasis
    Swarna Mehrotra
    Department of Cancer Biology, Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cancer Cell 17:53-64. 2010
    ..Therefore, IAPs are direct metastasis genes, and their antagonists could provide antimetastatic therapies in patients with cancer...
  90. ncbi miR-218 on the genomic loss region of chromosome 4p15.31 functions as a tumor suppressor in bladder cancer
    Shuichi Tatarano
    Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Int J Oncol 39:13-21. 2011
    ..31 is a tumor suppressive miRNA in BC. The identification of tumor suppressive miRNAs and their target genes on the basis of array-CGH analysis could provide new insights into the mechanisms of BC carcinogenesis...
  91. ncbi Possible future issues in the treatment of glioblastomas: special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis
    Florence Lefranc
    Laboratoire de Toxicologie, Institut de Pharmacie, Universite Libre de Bruxelles, Campus de la Plaine, Blvd du Triomphe, 1050 Brussels, Belgium
    J Clin Oncol 23:2411-22. 2005
    ....
  92. pmc Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion
    J Chen
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Br J Cancer 102:351-60. 2010
    ..However, the events that lead to increased Notch activity during EMT of breast cancer cells are unknown...
  93. ncbi Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic
    Angeliki Voulgari
    Laboratory of Signal Mediated Gene Expression, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vasileos Constantinou Avenue, Athens 11635, Greece
    Biochim Biophys Acta 1796:75-90. 2009
    ..Finally, it cites the recent literature concerning the mechanisms of drug resistance related to EMT in the context of anti-tumour therapies and proposes related new targets for therapy...
  94. ncbi Genomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro
    Lars Dyrskjøt
    Molecular Diagnostic Laboratory, Department of Molecular Medicine, Aarhus University Hospital, Skejby, DK 8200 Aarhus N, Denmark
    Cancer Res 69:4851-60. 2009
    ..The findings reported here indicate that several miRNAs are differentially regulated in bladder cancer and may form a basis for clinical development of new biomarkers for bladder cancer...
  95. pmc Loss of mir-146a function in hormone-refractory prostate cancer
    Shi Lung Lin
    Department of Cell and Neurobiology, Keck School of Medicine, BMT 403, University of Southern California, 1333 San Pablo Street, Los Angeles, CA 90033, USA
    RNA 14:417-24. 2008
    ....
  96. pmc Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases
    Shuying Liu
    Department of Systems Biology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Cell 15:539-50. 2009
    ..Thus, ATX and LPA receptors can contribute to the initiation and progression of breast cancer...
  97. pmc Gene expression profiling of the tumor microenvironment during breast cancer progression
    Xiao Jun Ma
    bioTheranostics, Inc, 11025 Roselle Street, San Diego, CA 92121, USA
    Breast Cancer Res 11:R7. 2009
    ..We conducted a comparative analysis of global gene expression changes in the stromal and epithelial compartments during breast cancer progression from normal to preinvasive to invasive ductal carcinoma...
  98. ncbi NF-kappaB and epithelial to mesenchymal transition of cancer
    Chengyin Min
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118 2394, USA
    J Cell Biochem 104:733-44. 2008
    ..Overall, NF-kappaB is identified as a key target in prevention and in the treatment of invasive carcinomas...
  99. ncbi NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2
    H L Chua
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Oncogene 26:711-24. 2007
    ..MCF10A cells chronically exposed to tumor necrosis factor alpha (TNFalpha), a potent NF-kappaB inducer, also exhibited the EMT-like phenotype and ZEB-1/ZEB-2 induction, both of which were reversed following TNFalpha withdrawal...
  100. pmc The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
    Li Bing Song
    State Key Laboratory of Oncology in South China, Sun Yat sen University Cancer Center, Guangzhou, People s Republic of China
    J Clin Invest 119:3626-36. 2009
    ..Our results provide functional and mechanistic links between the oncoprotein Bmi-1 and the tumor suppressor PTEN in the development and progression of cancer...
  101. ncbi microRNA-146b inhibits glioma cell migration and invasion by targeting MMPs
    Hongping Xia
    Integrative Chemical Biology Laboratory, Institute of Molecular Technology, Department of Chemistry, The University of Hong Kong, Pokfulam, Hong Kong, China
    Brain Res 1269:158-65. 2009
    ..Taken together, our findings suggest that miR-146b is involved in glioma cell migration and invasion by targeting MMPs, and implicate miR-146b as a metastasis-inhibiting miRNA in glioma...

Research Grants58

  1. GENE SPECIFIC MUTATIONS IN SKIN INDUCED BY PEROXYNITRITE
    Fredika Robertson; Fiscal Year: 2001
    ..The hypothesis driving this research is that NO and peroxynitrite are mutagenic, and could be important contributors to oxidative DNA damage and mutation in human epidermal keratinocytes at sites of inflammation. ..
  2. BEHAVIORAL CORRELATES OF RECURRENCE IN BREAST CANCER
    Bette Caan; Fiscal Year: 2003
    ..It will also establish a resource for future studies where predictors of long term survival can be examined ..
  3. Telomere dysfunction, oxidative damage and breast cancer risk
    Jing Shen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  4. Inflammatory Biomarkers and Colorectal Cancer Risk
    Gong Yang; Fiscal Year: 2010
    ..Overall, this study will contribute significantly to the understanding of the role of inflammation in the etiology of CRC and to the development of new strategies for the assessment of CRC risk. ..
  5. Intrnational Clubfoot Symposium
    Jose Morcuende; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  6. Translational Studies of Fn14 in Brain Tumors
    Nhan Tran; Fiscal Year: 2007
    ..The results from these studies will profile the suitability and applicability of Fn 14 as a target for therapeutic intervention. ..
  7. Imageable tumor-targeting bacteria
    Ming Zhao; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  8. Prognosis and Effectiveness of Advanced Lung Cancer Treatment in the Elderly
    Juan P Wisnivesky; Fiscal Year: 2010
    ..This study will provide information regarding the efficacy of several therapies and may help resolve several controversies regarding the staging and treatment of elderly patients with advanced stage lung cancer. ..
  9. Therapeutic hair follicle-derived neurospheres
    Meng Yang; Fiscal Year: 2007
    ..Human hair- follicle bulge cells will be further characterized and developed for therapeutic potential for nerve regeneration in Phase III. [unreadable]..
  10. Antigen specific modeling of glioma immunotherapy
    Andrew Parsa; Fiscal Year: 2007
    ..The long-term goal of this proposal is to facilitate the development of Dr. Parsa into an independent investigator capable of making meaningful scientific contributions. ..
  11. Dual-color tumor-host imaging models
    Meng Yang; Fiscal Year: 2007
    ..These models have significant commercial potential for discovery and development of stroma-targeted and anti-angiogenesis drugs. [unreadable] [unreadable] [unreadable]..
  12. EXPERIMENTAL TRANSFORMATION OF HUMAN MELANOCYTES IN VIVO
    Meenhard Herlyn; Fiscal Year: 2008
    ..Our unique model allows a systematic dissection of the biological and molecular events leading to human melanoma formation. ..
  13. Collagen XV as a tumor and metastasis suppressor.
    Ann Harris; Fiscal Year: 2008
    ..This series of experiments may generate new avenues for therapeutic intervention in pancreatic cancer, and other cancers of epithelial origin, that target the collagen XV proteoglycan. [unreadable] [unreadable] [unreadable]..
  14. Genetic Mapping of Familial Idiopathic Scoliosis
    Jose Morcuende; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  15. Synthesis and Characterization of Patterned Microvascular Networks
    Joe Tien; Fiscal Year: 2009
    ..In the long-term, engineered networks may enhance the perfusion of artificial tissues in vitro, and thereby overcome one of the primary obstacles in tissue engineering. ..
  16. Dermal-Epidermal Communication during Wound Healing
    Alan Wells; Fiscal Year: 2008
    ..These investigations will define key extracellular and intracellular molecules for wound resolution. These are potential targets for rationally designed interventions to promote normal wound healing and limit scarring. ..
  17. Biomarkers of UC Tumorigenesis
    Teresa A Brentnall; Fiscal Year: 2010
    ..Both of these goals will help provide the underpinnings for development of cancer prevention strategies in the future. ..
  18. Pancreatic Cancer Protein Biomarkers for Early Detection
    Teresa A Brentnall; Fiscal Year: 2010
    ....
  19. Development of Chronic Pancreatitis Biomarkers
    Teresa A Brentnall; Fiscal Year: 2010
    ..An accurate biomarker for chronic pancreatitis would be of enormous clinical benefit and could save time and costs in comparison to the current gold standard of endoscopic testing for the disease. ..
  20. Osteoporosis Prevention in Early Stage Breast Cancer
    Dawn Hershman; Fiscal Year: 2006
    ..abstract_text> ..
  21. Genetic Screening:Oncogene RAS-Based Inhibi*(RMI)
    Xiaodong Cheng; Fiscal Year: 2005
    ....
  22. Discovery of novel fluorescent reporter genes
    Ming Zhao; Fiscal Year: 2004
    ..Reporters with spectral properties that can be used for whole-body imaging of tumors in the lung and their metastases will be candidates for further development for numerous applications of multi-color imaging. ..
  23. INTEGRATION OF FIBROBLAST FUNCTIONING IN WOUND HEALING
    Alan Wells; Fiscal Year: 2003
    ..Understanding the delicate balance of these molecular mechanisms is important for rationally designing interventions to achieve normal wound healing. ..
  24. RHOMOCYCSTEINASE FOR HOMOCYSTEINE ASSAY
    Yuying Tan; Fiscal Year: 2002
    ..The tHCY enzymatic kits for these applications will be ready for commercial launch at this point. PROPOSED COMMERCIAL APPLICATION: Not Available ..
  25. SIGNALING MECHANISMS OF CELL MOTILITY & TUMOR METASTASIS
    Richard Klemke; Fiscal Year: 2002
    ..These studies should help to define the critical adhesion-dependent signal transduction events that regulate cell movement as it pertains to the invasive properties of tumor cells. ..
  26. Correlative Studies of erbB-2/HER2 and p53 in CALGB Pro.
    Daniel Hayes; Fiscal Year: 2005
    ....
  27. Self-Assembly of Mesostructure Biomaterials
    Joe Tien; Fiscal Year: 2004
    ..abstract_text> ..
  28. Inhibitors of 5alpha-reductase for acne therapy
    Lingna Li; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATIONS: Liposomal 4-MA will be developed as a topical selectively targeted therapeutic for acne for which they should be a very market. ..
  29. In Vitro Synthesis of a Microvascular Network
    Joe Tien; Fiscal Year: 2004
    ..This work will further determine the thickness of tissue that can be sustained metabolically by an engineered microvascular construct comprised of two interconnected plexuses. ..
  30. Second International Melanoma Research Congress
    Meenhard Herlyn; Fiscal Year: 2004
    ..This second congress will strengthen the field and solidify the ties between the different research and clinical communities. ..
  31. Evaluating the Effectiveness of Lung Cancer Treatment in the Elderly
    Juan Wisnivesky; Fiscal Year: 2009
    ..The findings from this project will provide information that can directly impact the care of elderly patients with NSCLC and inform the design of future trials of lung cancer treatment strategies. ..
  32. The Progesterone Receptor Gene and Ovarian Cancer Risk
    CELESTE PEARCE; Fiscal Year: 2005
    ..We will also test our previous two case-control studies for any additional identified SNPs, including 326 cases and 493 controls (many of the SNPs have already been tested in these populations). ..
  33. Adenoviral GFP targeting of metastatic human tumors using multiple delivery route
    Hiroyuki Kishimoto; Fiscal Year: 2008
    ..Having obtained these results, we can move forward in the Phase II grant application with experiments to bring OBP-401 to the clinic for use in cancer surgery in human patients. [unreadable] [unreadable] [unreadable]..
  34. Enzyme therapy for hyperhomocysteinemia
    Yuying Tan; Fiscal Year: 2005
    ..Phase II results will lead to an IND for MEGC-PEG-rMETase for end stage renal disease patients and other patients with intractable hyperhomocysteinemia and high cardiovascular disease mortality. ..
  35. PAR SIGNALING AND PROTECTIVE PATHWAYS IN INFLAMMATION AND SEPSIS
    Wolfram Ruf; Fiscal Year: 2010
    ..3. ..
  36. DEFORMATION-DEPENDENT ENZYME CLEAVAGE OF COLLAGEN
    Peter Torzilli; Fiscal Year: 2005
    ..The findings from this study could fundamentally change our concepts of matrix enzyme function and the design of intervention approaches to include the effect the mechanical environment has on the ECM. ..
  37. Targeted tumoricidal bacteria
    Ming Zhao; Fiscal Year: 2007
    ..Future human trials of the tumor-killing bacteria can be held after the Phase I and Phase II grant periods are completed. [unreadable] [unreadable] [unreadable]..
  38. Orthotopic models of tumor angiogenesis and blood flow
    Meng Yang; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  39. TARGETING SIGNALING OF THE TISSUE FACTOR PATHWAY
    Wolfram Ruf; Fiscal Year: 2007
    ..abstract_text> ..
  40. c-erbB-2 and Risk of Contralateral Breast Cancer
    Christopher Li; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  41. Nitric oxide as a target for dietary intervention in colitis
    Michael Wargovich; Fiscal Year: 2007
    ..The overall goal of this application is to provide the public some assurance that the dietary supplements gingko and ginseng, have the capacity to alleviate colitis. [unreadable] [unreadable] [unreadable]..
  42. Near Infrared Diffused Light Imaging with Ultrasound
    Quing Zhu; Fiscal Year: 2002
    ..Completion of this research plan will serve to validate a novel method for detection and diagnosis of breast lesions, resulting in new opportunities for early detection and appropriate treatment of breast carcinoma. ..
  43. Bile acid-induced colon cancer cell proliferation
    Jean Pierre Raufman; Fiscal Year: 2009
    ..3c) The mechanism whereby bile acids activate metalloproteases will be determined by exploring the roles of PKC, Ca2+, and Src in bile acid-induced HB-EGF release. ..
  44. CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2007
    ..abstract_text> ..
  45. HB-EGF AND ITS RECEPTORS
    Michael Klagsbrun; Fiscal Year: 2003
    ..abstract_text> ..
  46. CHARACTERIZATION OF NEUROPILIN, A NOVEL VEGF RECEPTOR
    Michael Klagsbrun; Fiscal Year: 2008
    ..abstract_text> ..
  47. CIRCULATING INHIBITORS OF ENDOTHELIAL CELL GROWTH
    Michael Klagsbrun; Fiscal Year: 2008
    ..Currently, all angiogenesis inhibitors in clinical application are employed only after the angiogenic switch. [unreadable] [unreadable]..
  48. Cancer Prevention by West African Medicinal Plants
    Michael Wargovich; Fiscal Year: 2007
    ..We have unique access to actual plants with purported anti-inflammatory activity used by actual traditional healers in West Africa. [unreadable] [unreadable]..
  49. Medications, Genetic Variability & Breast Cancer
    Polly Newcomb; Fiscal Year: 2007
    ..abstract_text> ..
  50. Depo-Provera and Breast Cancer: Epidemiology/Pathology
    Christopher Li; Fiscal Year: 2009
    ..such as parity and body mass index, modify this association?;and (3) Does the association between DMPA and breast cancer risk vary by histologic type or by the expression of steroid receptors including ERq, ERft, and PR? ..
  51. Molecular Changes Associated with PCa bone metastases
    Kenneth Pienta; Fiscal Year: 2006
    ..This knowledge could lead to the development of better biomarkers of disease progression as well as targets for therapy. ..
  52. Colon Cancer Pathways: Hyperplastic Polyps and Adenomas
    Polly Newcomb; Fiscal Year: 2009
    ..The results of this study will have implications for understanding the biology and prevention of colorectal cancer. ..
  53. Colon Cancer Risk: IGF Polymorphisms/Lifestyle Factors
    Polly Newcomb; Fiscal Year: 2003
    ..As an adjunct to an existing study, this is an efficient, valid cost-effective approach to the investigation of the association between polymorphisms and cancer risk. ..
  54. Protein Biomarkers of Cancer Risk in Older Persons
    Christopher Li; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  55. Hormones and Colon Cancer: Epigenetic Subtypes, Risk, and Survival
    Polly Newcomb; Fiscal Year: 2009
    ....
  56. Use of Cystatin C to Combat TGF-Beta Tumorigenesis
    WILLIAM SCHIEMANN; Fiscal Year: 2009
    ..abstract_text> ..
  57. LEPTIN, IGFS AND COLORECTAL ADENOMA CANCER RISK
    Polly Newcomb; Fiscal Year: 2005
    ..This study may provide insights into the biologic mechanisms whereby obesity is associated with colorectal cancer risk, as well as have practical implications for cancer prevention. ..