hemangiosarcoma

Summary

Summary: A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)

Top Publications

  1. ncbi Angiosarcoma
    Robin J Young
    Academic Unit of Surgical Oncology, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    Lancet Oncol 11:983-91. 2010
  2. pmc Primary pleural angiosarcoma as a mimicker of mesothelioma: a case report **VS**
    Yu Chien Kao
    Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taiwan
    Diagn Pathol 6:130. 2011
  3. ncbi Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor
    Min S Park
    Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Opin Oncol 22:351-5. 2010
  4. pmc Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma
    Beth A Tamburini
    Integrated Department of Immunology, University of Colorado, Denver, School of Medicine, Denver, CO, USA
    BMC Cancer 10:619. 2010
  5. pmc The co-expression of cytokeratin and p63 in epithelioid angiosarcoma of the parotid gland: a diagnostic pitfall
    Xu Yong Lin
    Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, 110001, China
    Diagn Pathol 7:118. 2012
  6. pmc Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed
    Beth A Tamburini
    Integrated Department of Immunology, University of Colorado Denver, Denver, Colorado, USA
    PLoS ONE 4:e5549. 2009
  7. ncbi Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
    H W Chang
    Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 276:1848-50. 1997
  8. ncbi Splenic angiosarcoma: a clinicopathologic and immunophenotypic study of 28 cases
    T S Neuhauser
    Department of Hematopathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Mod Pathol 13:978-87. 2000
  9. ncbi Expression of Fli-1, a nuclear transcription factor, distinguishes vascular neoplasms from potential mimics
    A L Folpe
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    Am J Surg Pathol 25:1061-6. 2001
  10. ncbi Postradiation angiosarcoma of the small intestine: a case report and review of literature
    Maria Luisa C Policarpio-Nicolas
    Department of Pathology, Northwestern Memorial Hospital, Chicago, IL 60611, USA
    Ann Diagn Pathol 10:301-5. 2006

Research Grants

  1. Muscular Dystrophy Cooperative Research Center
    Jeffrey Chamberlain; Fiscal Year: 2007
  2. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2009
  3. TRANSGLUTAMINASE PROMOTES CPPD DISEASE IN AGING JOINTS
    Ann Rosenthal; Fiscal Year: 2007
  4. Measure Validation and RCT- Dog Bone Cancer Pain Model
    Dorothy Brown; Fiscal Year: 2008
  5. STI571 Therapy for Gastrointestinal Stromal Tumors
    Ronald DeMatteo; Fiscal Year: 2002
  6. DYSTROPHIN REPLACEMENT IN MDX MICE
    Jeffrey Chamberlain; Fiscal Year: 2004
  7. Natural Killer Dendritic Cells in Listeria Infection
    Ronald DeMatteo; Fiscal Year: 2007
  8. Matrix proteins promote matrix vesicle mineralization
    Ann Rosenthal; Fiscal Year: 2007
  9. Functional and Tissue Specific Effects of VHL Mutations
    WENDY RATHMELL; Fiscal Year: 2007

Detail Information

Publications271 found, 100 shown here

  1. ncbi Angiosarcoma
    Robin J Young
    Academic Unit of Surgical Oncology, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, UK
    Lancet Oncol 11:983-91. 2010
    ..In this review we discuss angiosarcoma and its current management, with a focus on clinical trials investigating the treatment of advanced disease...
  2. pmc Primary pleural angiosarcoma as a mimicker of mesothelioma: a case report **VS**
    Yu Chien Kao
    Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taiwan
    Diagn Pathol 6:130. 2011
    ..We report the case of a 49-year-old male patient with primary pleural angiosarcoma, who presented with initial hemothorax, followed by a rapid progress to an inoperable status...
  3. ncbi Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor
    Min S Park
    Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Opin Oncol 22:351-5. 2010
    ..Therapeutic agents that target this pathway are reviewed...
  4. pmc Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma
    Beth A Tamburini
    Integrated Department of Immunology, University of Colorado, Denver, School of Medicine, Denver, CO, USA
    BMC Cancer 10:619. 2010
    The etiology of hemangiosarcoma remains incompletely understood. Its common occurrence in dogs suggests predisposing factors favor its development in this species...
  5. pmc The co-expression of cytokeratin and p63 in epithelioid angiosarcoma of the parotid gland: a diagnostic pitfall
    Xu Yong Lin
    Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, 110001, China
    Diagn Pathol 7:118. 2012
    ..Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/6548916707504750...
  6. pmc Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed
    Beth A Tamburini
    Integrated Department of Immunology, University of Colorado Denver, Denver, Colorado, USA
    PLoS ONE 4:e5549. 2009
    ..complementary approach using gene expression profiling in a naturally occurring endothelial sarcoma of dogs (hemangiosarcoma)...
  7. ncbi Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
    H W Chang
    Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 276:1848-50. 1997
    ..CEFs transformed with either gene showed elevated levels of phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and activation of Akt kinase...
  8. ncbi Splenic angiosarcoma: a clinicopathologic and immunophenotypic study of 28 cases
    T S Neuhauser
    Department of Hematopathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Mod Pathol 13:978-87. 2000
    ..The majority of splenic angiosarcomas coexpress histiocytic and endothelial markers by immunohistochemical analysis, which suggest that some tumors may originate from splenic lining cells...
  9. ncbi Expression of Fli-1, a nuclear transcription factor, distinguishes vascular neoplasms from potential mimics
    A L Folpe
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    Am J Surg Pathol 25:1061-6. 2001
    ..As the first nuclear, rather than cytoplasmic or membranous marker of endothelium, Fli-1 immunostaining also generally lacks cytoplasmic staining artifacts that are the result of endogenous peroxidases or biotin...
  10. ncbi Postradiation angiosarcoma of the small intestine: a case report and review of literature
    Maria Luisa C Policarpio-Nicolas
    Department of Pathology, Northwestern Memorial Hospital, Chicago, IL 60611, USA
    Ann Diagn Pathol 10:301-5. 2006
    ..The correct diagnosis of PRA depends upon histomorphologic identification of vascular differentiation, coupled with immunohistochemical expression of endothelial-related markers...
  11. ncbi Treatment with DAV for advanced-stage hemangiosarcoma in dogs
    Nikolaos G Dervisis
    Center for Comparative Oncology, Michigan State University, East Lansing, MI, USA
    J Am Anim Hosp Assoc 47:170-8. 2011
    b>Hemangiosarcoma (HSA) is an aggressive disease that is fairly common in the dog. The authors evaluated a doxorubicin, dacarbazine, and vincristine (DAV) combination protocol in dogs with nonresectable stage II and stage III HSA...
  12. ncbi A 14-year retrospective review of angiosarcoma: clinical characteristics, prognostic factors, and treatment outcomes with surgery and chemotherapy
    Matthew G Fury
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021 6007, USA
    Cancer J 11:241-7. 2005
    ..Characteristics at presentation and prognostic factors are reviewed. For patients with unresectable disease, progression-free survival with various chemotherapy regimens is described...
  13. ncbi Neoadjuvant chemotherapy-specific and overall treatment outcomes in patients with cutaneous angiosarcoma of the face with periorbital involvement
    Sheri L Demartelaere
    Section of Ophthalmology, Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 30:639-46. 2008
    ..The goal of this report was to investigate the overall treatment outcomes and the neoadjuvant chemotherapy-specific outcomes in patients with cutaneous angiosarcoma of the face with periorbital involvement...
  14. ncbi Rapidly progressive metastatic multicentric epithelioid angiosarcoma of the small bowel: a case report and a review of literature
    Jaspreet S Grewal
    Department of Internal Medicine, St Joseph Mercy Hospital, Reichert Health Center, 5333 McAuley Drive, Suite 3009, Ann Arbor, MI 48106 0995, USA
    Int J Colorectal Dis 23:745-56. 2008
    ..Angiosarcoma is a rare high-grade neoplasm that frequently involves the skin and subcutaneous tissue. Rarely, angiosarcoma can occur in the gastrointestinal tract where it frequently exhibits multicentric epithelioid morphology...
  15. ncbi Angiosarcoma of the eyelid: a clinicopathologic comparison between isolated unilateral tumors and tumors demonstrating extrapalpebral involvement
    John A Papalas
    Departments of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Dermatopathol 32:694-9. 2010
    ..When extrapalpebral involvement is ruled out by clinical and radiographic examination, patients with isolated involvement seem to fare better compared with patients with eyelid involvement secondary to more regionally extensive tumors...
  16. ncbi The VEGF-system in primary pulmonary angiosarcomas and haemangioendotheliomas: new potential therapeutic targets?
    Elvira Stacher
    Department of Pathology, Medical University of Graz, Auenbruggerplatz 25, Graz 8036, Austria
    Lung Cancer 65:49-55. 2009
    ..The observed positivity for the factors of the VEGF-signalling pathway points towards a possible new therapeutic option in the therapy of pulmonary vascular tumors by a blockade of the ligands or their receptors...
  17. pmc MDM-2 oncoprotein overexpression, p53 gene mutation, and VEGF up-regulation in angiosarcomas
    C Zietz
    Department of Pathology, Ludwig Maximilians University of Munich, Munchen, Federal Republic of Germany
    Am J Pathol 153:1425-33. 1998
    ..This may be a key event in the pathogenesis of human angiosarcomas. The increased VEGF expression observed supports this hypothesis...
  18. ncbi β-Adrenergic receptor expression in vascular tumors
    Karen M Chisholm
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mod Pathol 25:1446-51. 2012
    ..Additional study is warranted, as therapeutic options are limited for some patients with these lesions...
  19. ncbi An open-label, multicenter, phase II study of bevacizumab for the treatment of angiosarcoma and epithelioid hemangioendotheliomas
    M Agulnik
    Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago 60611, USA
    Ann Oncol 24:257-63. 2013
    ..To determine efficacy and safety of bevacizumab, a recombinant humanized antibody against vascular endothelial growth factor (VEGF), in the treatment of metastatic or locally advanced angiosarcoma and epithelioid hemangioendotheliomas...
  20. pmc The role of hypoxia in 2-butoxyethanol-induced hemangiosarcoma
    Daphna Laifenfeld
    Genstruct, Inc, Cambridge, Massachusetts 02140, USA
    Toxicol Sci 113:254-66. 2010
    ..would result in local tissue hypoxia, a well-documented trigger for endothelial cell proliferation leading to hemangiosarcoma. Gene expression data from bone marrow (BM), liver, and spleen of mice exposed to a single dose (4 h) or ..
  21. ncbi Docetaxel: a therapeutic option in the treatment of cutaneous angiosarcoma: report of 9 patients
    Tohru Nagano
    Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Cancer 110:648-51. 2007
    ..However, there were only 3 case reports of the successful treatment of AS in elderly patients using docetaxel in combination with surgery and radiotherapy...
  22. ncbi Changing clinical presentation of angiosarcomas after breast cancer: from late tumors in edematous arms to earlier tumors on the thoracic wall
    Emelie Styring
    Department of Orthopedics, Lund University Hospital, 221 85 Lund, Sweden
    Breast Cancer Res Treat 122:883-7. 2010
    ..We conclude that the clinical presentation of angiosarcomas has changed, parallel with altered treatment principles for breast cancer...
  23. pmc Historical cohort study of 10 109 men in the North American vinyl chloride industry, 1942-72: update of cancer mortality to 31 December 1995
    K A Mundt
    Applied Epidemiology, PO Box 2424, Amherst, MA 01004, USA
    Occup Environ Med 57:774-81. 2000
    ..Previous analyses indicated associations between employment in vinyl production and increased mortality risk from cancers of the liver and biliary tract, due to increased mortality from angiosarcoma of the liver, and brain cancer...
  24. ncbi Cutaneous angiosarcoma of the scalp: a multidisciplinary approach
    Timothy M Pawlik
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer 98:1716-26. 2003
    ..Angiosarcoma is a malignant tumor of vascular endothelial cells that arises in the head and neck. It is a rare, difficult to treat, and lethal tumor...
  25. ncbi Establishment of a human hemangiosarcoma cell line (ISO-HAS)
    M Masuzawa
    Department of Dermatology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Int J Cancer 81:305-8. 1999
    A cell line (ISO-HAS) has been established from tumor tissue of a human hemangiosarcoma arising on the scalp by the use of conditioned medium from a murine-phenotypic angiosarcoma cell line (ISOS-1)...
  26. ncbi Oral and salivary gland angiosarcoma: a clinicopathologic study of 29 cases
    Julie C Fanburg-Smith
    Department of Soft Tissue, Armed Forces Institute of Pathology, Washington, DC 20306, USA
    Mod Pathol 16:263-71. 2003
    ....
  27. pmc MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema
    Johanna Manner
    Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, D 68135 Mannheim, Germany
    Am J Pathol 176:34-9. 2010
    ..This finding may have implications both for the diagnosis and treatment of these tumors...
  28. pmc Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions
    Tianhua Guo
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Genes Chromosomes Cancer 50:25-33. 2011
    ..Secondary genetic hits, such as FLT4 gene coamplification or KDR mutations, may play a role in tumor progression as well as potential therapeutic targeting...
  29. pmc Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report
    Olga L Bohn
    Department of Pathology, Christus Mugerza UPAEP University Hospital, Puebla, 72000, Mexico
    Diagn Pathol 7:154. 2012
    ..Intravascular angiosarcomas are aggressive neoplasms, often associated with poor outcome...
  30. ncbi Angiosarcoma after conservation treatment for breast carcinoma: our experience and a review of the literature
    Janos Fodor
    Department of Radiotherapy, National Institute of Oncology, Budapest, Hungary
    J Am Acad Dermatol 54:499-504. 2006
    ..As shown by a review of the literature, angiosarcomas are often resistant to surgery, chemotherapy, and radiotherapy, and targeted therapy against tumor biological properties may be a new approach to angiosarcoma treatment...
  31. ncbi Angiosarcomas, a heterogeneous group of sarcomas with specific behavior depending on primary site: a retrospective study of 161 cases
    J Fayette
    Hospices Civils de Lyon, Universite Lyon 1, Hopital Edouard Herriot, Oncologie Médicale, Pavillon E, Lyon, France
    Ann Oncol 18:2030-6. 2007
    ..Angiosarcomas are rare, heterogeneous and a retrospective study was conducted to describe their natural history...
  32. ncbi Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma
    E B Dickerson
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, USA
    Vet Pathol 42:618-32. 2005
    ..that could contribute to the origin or progression of naturally occurring canine endothelial tumors (hemangiosarcoma)...
  33. ncbi Expression of vascular endothelial growth factor, basic fibroblast growth factor, and their receptors (flt-1, flk-1, and flg-1) in canine vascular tumors
    K Yonemaru
    Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    Vet Pathol 43:971-80. 2006
    ..growth factor (VEGF), its receptors (flt-1 and flk-1), and basic fibroblast growth factor (bFGF) in canine hemangiosarcoma (HSA) and hemangiomas was investigated by immunohistochemical analysis...
  34. ncbi Plasma vascular endothelial growth factor concentrations in healthy dogs and dogs with hemangiosarcoma
    C A Clifford
    University of Pennsylvania, Veterinary Teaching Hospital, Department of Clinical Sciences, School of Veterinary Medicine, Philadelphia 19104, USA
    J Vet Intern Med 15:131-5. 2001
    ..This study compared plasma VEGF concentrations in healthy client-owned dogs (n = 17) to dogs with hemangiosarcoma (HSA; n 16)...
  35. ncbi Autocrine and paracrine roles of VEGF/VEGFR-2 and VEGF-C/VEGFR-3 signaling in angiosarcomas of the scalp and face
    Wataru Tokuyama
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Hum Pathol 41:407-14. 2010
    ..These results suggest that not only VEGFR-2-mediated signal but also VEGFR-3-mediated signal may contribute to proliferation of vascular tumor cells as autocrine and paracrine signaling factors...
  36. ncbi Angiosarcoma involving the gastrointestinal tract: a series of primary and metastatic cases
    Kimberly H Allison
    Department of Anatomic Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
    Am J Surg Pathol 28:298-307. 2004
    ..Immunohistochemistry with vascular markers, CK20, and S-100 protein may be helpful in differentiating angiosarcoma from carcinoma and melanoma...
  37. pmc Primary angiosarcoma of the ovary with prominent fibrosis of the ovarian stroma. Case report of an 81-year old patient
    Hans Bösmüller
    Department of Pathology, Krankenhaus Barmherzige Schwestern Linz, Austria
    Diagn Pathol 6:65. 2011
    ..Most reports refer to younger individuals, aged from 7 to 46 years, and only 2 case reports could be found for patients older than 64 years. Here we present a very unusual case of angiosarcoma in a 81-year-old patient...
  38. ncbi Risk of angiosarcoma following breast conservation: a clinical alert
    John G West
    Breast Care Center, Cordelia Knott Center for Wellness, Orange, California 92868, USA
    Breast J 11:115-23. 2005
    ....
  39. ncbi A retrospective study of visceral and nonvisceral hemangiosarcoma and hemangiomas in domestic animals
    Patricia C Schultheiss
    Veterinary Diagnostic Laboratory, Colorado State University, Fort Collins, CO 80523, USA
    J Vet Diagn Invest 16:522-6. 2004
    Cases of hemangiosarcoma submitted to the Colorado State University Veterinary Diagnostic Laboratory during a 6-year period were reviewed...
  40. pmc Angiosarcoma of the oral cavity
    Tadashi Terada
    Department of Pathology, Shizuoka City Shimizu Hospital, Shimizu ku, Shizuoka, Japan
    Head Neck Pathol 5:67-70. 2011
    ..The Ki-67 labeling was 46%. The lymphoid tissue in the tumor was positive for CD20, CD45, CD45RO, and CD10. A pathological diagnosis of angiosarcoma was made. No metastatic lesions are found now. Radical operation is planned now...
  41. ncbi Angiosarcoma of the breast: a clinicopathologic analysis of cases from the last 10 years
    Xiao Yun Wang
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Ann Diagn Pathol 13:147-50. 2009
    ..Rosen's method for grading breast angiosarcoma is easy to implement and correlates well with clinical outcome. There are no distinct clinical or histologic differences between primary and postradiation breast angiosarcomas...
  42. pmc KDR activating mutations in human angiosarcomas are sensitive to specific kinase inhibitors
    Cristina R Antonescu
    Department of Pathology, Memorial Sloan Kettering Cancer, New York, New York 10065, USA
    Cancer Res 69:7175-9. 2009
    ..These data provide a basis for the activity of vascular endothelial growth factor receptor-directed therapy in the treatment of primary and radiation-induced AS...
  43. ncbi Angiosarcoma of the spleen clinically presenting as metastatic ovarian cancer. A case report and review of the literature
    Jose R Valbuena
    Department of Pathology and Laboratory Medicine, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4095, USA
    Ann Diagn Pathol 9:289-92. 2005
    ..However, histopathologic examination of the specimen showed the tumor to be of a primary angiosarcoma. We believe that the lengthy exposure to radiation may have played a role in the histopathogenesis of this neoplasm in this patient...
  44. ncbi Cutaneous angiosarcoma as a delayed complication of radiation therapy for carcinoma of the breast
    Jaggi Rao
    Division of Dermatology and Cutaneous Sciences, University of Alberta, Edmonton, Canada
    J Am Acad Dermatol 49:532-8. 2003
    ..Treatment should be aggressive and include local surgery with consideration of adjuvant systemic chemotherapy...
  45. ncbi Long-term outcomes in patients with radiation-associated angiosarcomas of the breast following surgery and radiotherapy for breast cancer
    Keila E Torres
    Department of Surgical Oncology, UT MD Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 20:1267-74. 2013
    ..Therefore, we sought to identify clinicopathologic factors associated with local and distant recurrence and disease-specific survival (DSS)...
  46. ncbi Radiation therapy for angiosarcoma
    Jon R Ward
    Department of Radiation Oncology, University of Florida Health Science Center, 2000 SW Archer Rd, Gainesville, Florida 32608, USA
    Head Neck 25:873-8. 2003
    ..Between 1964 and 1998, 19 patients with histologically proven angiosarcoma were treated with curative intent with radiation therapy...
  47. pmc Chylous ascites secondary to small-bowel angiosarcoma
    Amanda Selk
    Faculty of Medicine, Department of Pathology, University of Western Ontario, London, Ont
    Can J Surg 47:383-4. 2004
  48. ncbi Angiosarcoma: state of the art and perspectives
    Nicolas Penel
    EORTC Headquarters, Belgium
    Crit Rev Oncol Hematol 80:257-63. 2011
    ..Biological evidences for the key role of angiogentic factors have been accumulated during the last years and support the further investigation of anti-angiogenetic agents alone and almost combination with chemotherapy in such disease...
  49. ncbi [Rupture of the spleen in angiosarcoma: a case report and review of the literature]
    Roberto Sivelli
    Clinica Chirurgica Generale e dei Trapianti d Organo Università degli Studi di Parma
    Chir Ital 57:377-80. 2005
    ..It is important to perform a splenectomy before splenic rupture owing to its negative impact on long-term survival...
  50. ncbi Left ventricular outflow tract obstruction secondary to hemangiosarcoma in a dog
    Maria Josefa Fernández-del Palacio
    Hospital Clinico Veterinario, Facultad de Veterinaria, Universidad de Murcia, Spain
    J Vet Intern Med 20:687-90. 2006
  51. ncbi Epidemiological and pathological characteristics of cardiac tumors: a clinical study of 242 cases
    Kun Yu
    Division of Cardiothoracic Surgery, Extracorporeal Circulation and Anatomic Pathology, Cardiovascular Institute and Fuwai Hospital, CAMS and PUMS, Beijing 100037, China
    Interact Cardiovasc Thorac Surg 6:636-9. 2007
    ..This study, using a relatively large sample, reveals the clinical incidences and pathological characteristics of various cardiac tumors in the Chinese population...
  52. pmc Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas: a pattern distinct from other sarcomas with complex genomics
    Antoine Italiano
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Cancer 118:5878-87. 2012
    ..The scale of genetic abnormalities in these pathways remains unknown in angiosarcoma (AS)...
  53. ncbi Continuous low-dose oral chemotherapy for adjuvant therapy of splenic hemangiosarcoma in dogs
    Susan Lana
    Animal Cancer Center, Department of Clinical Sciences, Colorado State University, Ft Collins, 80523, USA
    J Vet Intern Med 21:764-9. 2007
    b>Hemangiosarcoma (HSA) is a highly metastatic and often rapidly fatal tumor in dogs. At present, conventional adjuvant chemotherapy provides only a modest survival benefit for treated dogs...
  54. ncbi Cutaneous angiosarcoma
    William M Mendenhall
    Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA
    Am J Clin Oncol 29:524-8. 2006
    ..To discuss the treatment and outcomes for cutaneous angiosarcoma...
  55. ncbi Intimal angiosarcoma of the aorta with tumour embolisation causing mesenteric ischaemia. Report of a case diagnosed using CD31 immunohistochemistry in an intestinal resection specimen
    C Santonja
    Department of Pathology, Hospital Universitario de Getafe, Carretera de Toledo, km 12 5 Getafe E 28905, Madrid, Spain
    Virchows Arch 438:404-7. 2001
    ..This case emphasises the need for a wide panel of immunohistochemical antibodies when tumour emboli of unknown origin are under study...
  56. ncbi Expression of platelet-derived growth factor and its receptors in spontaneous canine hemangiosarcoma and cutaneous hemangioma
    S Abou Asa
    Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan
    Histol Histopathol 27:601-7. 2012
    b>Hemangiosarcoma (HSA) is a malignant neoplasia of vascular endothelial cells (ECs)...
  57. ncbi Survival times in dogs with right atrial hemangiosarcoma treated by means of surgical resection with or without adjuvant chemotherapy: 23 cases (1986-2000)
    Chick Weisse
    Section of Small Animal Surgery, Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    J Am Vet Med Assoc 226:575-9. 2005
    To determine survival times in dogs with right atrial hemangiosarcoma treated by means of pericardectomy and tumor resection, with or without adjuvant chemotherapy, and identify complications associated with treatment.
  58. ncbi Immunohistochemical analysis of ocular hemangiomas and hemangiosarcomas in dogs
    Heather L Chandler
    The Ohio State University, College of Optometry, 320 West 10th Avenue, Columbus, OH 43210, USA
    Vet Ophthalmol 12:83-90. 2009
    ..To determine if molecular markers typically associated with ultraviolet exposure could be detected in canine ocular hemangiomas (HA) and hemangiosarcomas (HSA)...
  59. ncbi Angiosarcomas of the breast: a review of 70 cases
    Nicole C Hodgson
    Juravinski Cancer Centre, McMaster University, Hamilton, Ontario
    Am J Clin Oncol 30:570-3. 2007
    ..As more women undergo breast-conserving therapy, the incidence can be expected to increase. The objective of this study was to review breast angiosarcomas diagnosed from 1981 to 2000 from our state cancer registry...
  60. ncbi Therapy insight: malignant primary cardiac tumors
    Michael J Reardon
    Methodist DeBakey Heart Center, Houston, TX 77030, USA
    Nat Clin Pract Cardiovasc Med 3:548-53. 2006
    ..Surgical resection of this sarcoma type often requires pneumonectomy and can require pulmonary root replacement...
  61. ncbi Cutaneous angiosarcoma: a case series with prognostic correlation
    Michael B Morgan
    Department of Pathology, University of South Florida College of Medicine, Tampa, Florida, USA
    J Am Acad Dermatol 50:867-74. 2004
    ..Cutaneous angiosarcoma (CA) is a rare and aggressive endothelial-derived sarcoma. Few large studies have examined the clinicopathologic and prognostic attributes of CA...
  62. ncbi Secondary intracranial neoplasia in the dog: 177 cases (1986-2003)
    J M Snyder
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Vet Intern Med 22:172-7. 2008
    ..This study investigates the frequency, location, and clinical findings associated with 177 secondary brain tumors in dogs...
  63. ncbi Small-bowel hemangiosarcoma and capsule endoscopy
    F K Knop
    Dept of Gastrointestinal Surgery K, H S Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
    Endoscopy 35:637. 2003
  64. ncbi Small intestinal angiosarcoma leading to perforation and acute abdomen: a case report and review of the literature
    Katalin Kelemen
    Arkadi M Rywlin Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA
    Arch Pathol Lab Med 128:95-8. 2004
    ..A broad panel of immunochemical markers might be necessary to establish the pathologic diagnosis...
  65. ncbi Angiosarcoma: a study of 98 cases with immunohistochemical evaluation of TLE3, a recently described marker of potential taxane responsiveness
    Wonwoo Shon
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    J Cutan Pathol 38:961-6. 2011
    ..Our study confirms the poor prognosis of angiosarcoma. Vasoformative angiosarcoma may have a more favorable prognosis. A lack of TLE3 expression in cutaneous angiosarcoma may reflect differing pathogenesis...
  66. ncbi Hemangiosarcoma of the adrenal glands: CT findings in two cases
    F Ferrozzi
    Istituto di Scienze Radiologiche, , Viale Gramsci, 14, Parma, Italy I-43100
    Abdom Imaging 26:336-9. 2001
    ..A prospective diagnosis cannot be made by imaging alone, and pathology represents the discriminating method for a correct diagnosis...
  67. ncbi Potent inhibition of hemangiosarcoma development in mice by cidofovir
    S Liekens
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroederstraat 10, B 3000 Leuven, Belgium
    Int J Cancer 92:161-7. 2001
    ..afforded a prominent protection against the growth of intraperitoneally or intracerebrally inoculated hemangiosarcoma cells in SCID mice...
  68. ncbi Small bowel intussusception caused by intestinal angiosarcomatosis: usefulness of MR enteroclysis with infusion of water through a nasojejunal catheter
    Shoichi Ogawa
    Department of Radiology, Juntendo University Urayasu Hospital, 2 1 1, Tomioka, Urayasu, Chiba 279 0021, Japan
    Eur Radiol 12:534-6. 2002
    ..We report a case of intestinal angiosarcomatosis manifesting as jejuno-jejunal intussusception...
  69. ncbi Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas
    A L Folpe
    Department of Pathology, Emory University, Atlanta, Georgia, USA
    Mod Pathol 13:180-5. 2000
    ..However, the expression of VEGFR-3 by certain AS having Kaposi-like areas, a prominent lymphocytic infiltrate, or hobnail endothelium may define subset(s) having phenotypic, if not pathogenetic and biologic, differences...
  70. ncbi Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion
    David R Lucas
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Pathol Lab Med 133:1804-9. 2009
    ..Recently, vascular-type atypical vascular lesion, which resembles hemangioma, has been described, thus expanding the definition of this entity...
  71. ncbi Concurrent splenic and right atrial mass at presentation in dogs with HSA: a retrospective study
    Sarah E Boston
    Department of Clinical Studies, University of Guelph, Guelph, ON, Canada
    J Am Anim Hosp Assoc 47:336-41. 2011
    The objective of this retrospective study was to evaluate the presence of concurrent splenic and cardiac hemangiosarcoma (HSA)...
  72. ncbi Vascular soft-tissue sarcomas. An analysis of tumor-related mortality
    M S Karpeh
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Arch Surg 126:1474-81. 1991
    ..The survival of these patients depends on complete surgical resection and is independent of individual histologic characteristics of the tumor...
  73. ncbi Angiosarcoma of the small intestine
    A Mohammed
    Department of Pathology, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria
    Ann Afr Med 10:246-8. 2011
    ..It presented in a 25-year-old woman with multiple dissemination and rapid fatality. Diagnosis was based on histological morphology using Hematoxylin and Eosin (H and E) stains, plus reticulin special stain to outline the vascular nature...
  74. pmc Radiation-associated angiosarcoma after breast cancer: high recurrence rate and poor survival despite surgical treatment with R0 resection
    Jojanneke M Seinen
    Department of Surgical Oncology, University of Groningen University Medical Center, Groningen, The Netherlands
    Ann Surg Oncol 19:2700-6. 2012
    ..We characterized a population-based cohort of patients with secondary angiosarcomas from two tertiary hospitals to investigate this complication with respect to surgical treatment and outcome...
  75. ncbi Management of angiosarcoma
    G Thomas Budd
    Department of Hematology and Medical Oncology, The Cleveland Clinic Foundation, R35, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Curr Oncol Rep 4:515-9. 2002
    ..One logical strategy is to investigate antiangiogenic therapies in this endothelial tumor. Improved therapy for this tumor will come only with greater understanding of its biology...
  76. pmc Efficacy of Tie2 receptor antagonism in angiosarcoma
    Jason R Hasenstein
    Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA
    Neoplasia 14:131-40. 2012
    ..These data identify Tie2 antagonism as a potential novel, targeted therapy for angiosarcomas and provide a foundation for further investigation of Tie2 inhibition, alone and in combinations, in the management of this disease...
  77. pmc Haploinsufficiency of the genes encoding the tumor suppressor Pten predisposes zebrafish to hemangiosarcoma
    Suma Choorapoikayil
    Hubrecht Institute KNAW and University Medical Center, CT, Utrecht, The Netherlands
    Dis Model Mech 5:241-7. 2012
    ..A single tumor was identified in 42 ptena(-/-)ptenb(+/-) fish and was also diagnosed as hemangiosarcoma. Immunohistochemistry indicated that the tumor cells in ptena(+/-)ptenb(-/-) and ptena(-/-)ptenb(+/-) fish ..
  78. pmc Ruptured angiosarcoma of the liver treated by emergency catheter-directed embolization
    Christine Leowardi
    Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    World J Gastroenterol 12:804-8. 2006
    ..Here, we report a case of a patient with a ruptured hepatic angiosarcoma which was treated by emergency catheter-directed embolization, followed by left-sided hemihepatectomy...
  79. pmc Hepatic angiosarcoma manifested as recurrent hemoperitoneum
    Seung Woo Lee
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Dae Jeon St Mary s Hospital, The Catholic University of Korea, 520 2 Dae Heung Dong, Joong Gu, Dae Jeon, Seoul 301 723, Korea
    World J Gastroenterol 14:2935-8. 2008
    ..Although hepatic angiosarcoma usually presents with unspecific symptoms, it rapidly progresses and has a high mortality. We report a rare case of primary hepatic angiosarcoma manifested as recurrent hemoperitoneum...
  80. pmc The risk of angiosarcoma following primary breast cancer
    W Cozen
    University of Southern California School of Medicine, Department of Preventive Medicine, Los Angeles 90033, USA
    Br J Cancer 81:532-6. 1999
    ..9-152.8). A strong increase in risk after breast cancer was also observed for angiosarcoma of the chest and breast (OR = 11.6, 95% CI = 4.3-26.1) and for other sarcomas of the chest and breast (OR = 3.3, 95% CI = 1.1-1.7)...
  81. ncbi Epithelioid haemangiosarcoma of the thyroid gland. Report of six cases from a non-Alpine region
    A Ryska
    Department of Pathology, Charles University Medical Faculty Hospital, Hradec Kralove, Czech Republic
    Histopathology 44:40-6. 2004
    ..To report a series of six cases of thyroid haemangiosarcoma (HAS) from a non-Alpine region...
  82. ncbi Differential expression of active mitogen-activated protein kinase in cutaneous endothelial neoplasms: implications for biologic behavior and response to therapy
    J L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA
    J Am Acad Dermatol 44:193-7. 2001
    ..Activation of mitogen-activated protein kinase (MAPK) is an important signal transduction mechanism that may predict response of a tumor to chemotherapy...
  83. ncbi [Postirradiation angiosarcoma of the breast]
    Gergely Vertse
    Fovárosi Onkormányzat Károlyi Sándor Kórház és Rendelointézet Altalános Sebészeti Osztály 1041 Budapest Nyár u 103
    Magy Seb 63:164-7. 2010
    ..Only radical surgical intervention can provide successful treatment. Authors present a case of a 56-y-old woman who underwent BCT and radiotherapy. 10 years later secondary AS occurred in the remaining breast...
  84. ncbi Angiosarcoma: clinical and molecular insights
    Guy Lahat
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg 251:1098-106. 2010
    ..We sought to evaluate AS natural history in the largest patient cohort reported to date and further unravel commonly deregulated molecular events of potential therapeutic utility...
  85. ncbi [Angiosarcoma as a rare differential diagnosis in spontaneous rupture of the spleen]
    A Maier
    Klinik und Poliklinik für Chirurgie, Universitat Regensburg
    Chirurg 75:70-4. 2004
    ..Due to the small number of reported cases, there are no guidelines for adjuvant or palliative therapy, and up to today all adjuvant means of radiotherapy and chemotherapy have not improved the prognosis of the patients...
  86. ncbi Angiosarcoma in a pregnant woman presenting with pericardial tamponade--a case report and review of the literature
    Nassir A Azimi
    Yale University School of Medicine, Division of Cardiovascular Medicine, Yale New Haven Hospital, New Haven, CT 06520, USA
    Angiology 57:251-7. 2006
    ..They review the literature involving pericardial disease in pregnancy and discuss important issues in management and include a discussion of angiosarcoma...
  87. ncbi In vitro effects of the tyrosine kinase inhibitor, masitinib mesylate, on canine hemangiosarcoma cell lines
    S E Lyles
    Department of Small Animal Clinical Sciences, University of Florida, Gainesville, FL, USA
    Vet Comp Oncol 10:223-35. 2012
    This study evaluated the in vitro activity of masitinib mesylate against canine hemangiosarcoma (HSA) cell lines after treatment with increasing concentrations of masitinib mesylate (0.01-100 µM) for 24, 48 and 72 h...
  88. ncbi Angiosarcoma of the thyroid
    Petra Kalitova
    Department of Otorhinolaryngology and Head and Neck Surgery, 1st Faculty of Medicine, Faculty Hospital Motol, Charles University, V Uvalu 84, 150 06, Prague 5, Czech Republic
    Eur Arch Otorhinolaryngol 266:903-5. 2009
    b>Hemangiosarcoma of the thyroid gland is a very rare entity. The therapy of this tumor is difficult because of its locally aggressive and destructive behavior with a high recurrence rate...
  89. ncbi Evaluation of recombinant interleukin-2 immunotherapy for human hemangiosarcoma in a SCID mice model (WB-SCID)
    M Masuzawa
    Department of Dermatology, School of Medicine, Kitasato University, Sagamihara shi, Kanagawa ken 228 8555, Japan
    J Dermatol Sci 27:88-94. 2001
    We treated the patients with cutaneous hemangiosarcoma with recombinant interleukin-2 (rIL-2) immunotherapy that showed clear therapeutic effects. This immunotherapy is popular for the treatment of hemangiosarcoma in Japan...
  90. pmc SVR angiosarcomas can be rejected by CD4 costimulation dependent and CD8 costimulation independent pathways
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, and Veterans Administration Medical Center, Atlanta, GA 30322, USA
    Mol Med 8:551-8. 2002
    ..We wished to determine whether virally- induced endothelial tumors are rejected by CD4 and CD8 lymphocytes, and whether there are differences in requirements for costimulation in the rejection of these tumors by lymphocyte subsets...
  91. ncbi Spleen rupture due to primary angiosarcoma: a case report
    Ioannis M Koutelidakis
    2nd Department of Surgery, Aristoteles University of Thessaloniki, G Gennimatas General Hospital, Thessaloniki, Greece
    J Gastrointest Cancer 38:74-7. 2007
    ..Splenectomy prior to rupture seems to have a positive impact on long-term survival...
  92. pmc Fatal poorly differentiated angiosarcoma of the scalp
    Tadashi Terada
    Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka 424 8636, Japan
    Int J Clin Exp Pathol 3:541-4. 2010
    ..Chemoradiation and immunotherapy were performed. However, the tumor recurred several times, and ultimately metastasized to the systemic bones and lungs. The patient died of systemic carcinomatosis 33 months after the first manifestation...
  93. ncbi Dedifferentiated liposarcoma of the oral cavity with angiosarcomatous dedifferentiation
    Isabela Werneck da Cunha
    Department of Pathology, Centro de Tratamento e Pesquisa, Hospital do Cancer, A C Camargo, R Prof Antônio Prudente 211, Liberdade, 01509 900, Sao Paulo, Brazil
    Virchows Arch 446:456-9. 2005
    ..Divergent differentiation might also occur. To the best of our knowledge, there are only nine cases of dedifferentiated liposarcoma of the oral cavity, none of which show an angiosarcomatous dedifferentiation...
  94. ncbi Significance of the expression of phosphorylated signal transducer and activator of transcription-3, -Akt, and -cyclin D1 in angiosarcoma
    Nengxing Lin
    J Dermatol Sci 48:64-6. 2007
  95. ncbi Pulmonary artery angiosarcoma: a clinicopathologic and radiological correlation
    Lei Huo
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Ann Diagn Pathol 9:209-14. 2005
    ..The tumor cells were positive for CD31 and vimentin and negative for pan-cytokeratin, CD34, and S100. Two months after surgery, the patient was alive and well...
  96. ncbi Efficacy and toxicity of a dose-intensified doxorubicin protocol in canine hemangiosarcoma
    Karin U Sorenmo
    Department of Clinical Studies, Matthew J Ryan Veterinary Hospital of the University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA 19104, USA
    J Vet Intern Med 18:209-13. 2004
    ..was to evaluate the efficacy and toxicity of a single-agent, dose-intensified doxorubicin protocol in canine hemangiosarcoma (HSA). Canine HSA is a highly malignant tumor, and most affected dogs die within 6 months of diagnosis...
  97. ncbi Angiosarcoma in FNA smears: diagnostic accuracy, morphology, immunocytochemistry and differential diagnoses
    Z Pohar-Marinsek
    Department of Cytopathology, Institute of Oncology, Ljubljana, Slovenia
    Cytopathology 21:311-9. 2010
    ..The aim of our study was to analyse the diagnostic accuracy in recognizing angiosarcoma from fine needle aspiration (FNA) samples and to determine morphological features of angiosarcoma in cytology...
  98. ncbi Laparoscopic splenectomy for treatment of splenic hemangiosarcoma in a dog
    Fabien Collard
    Faculté de médecine vétérinaire de l Université de Montréal, Saint Hyacinthe, Canada
    Vet Surg 39:870-2. 2010
    ..To report laparoscopic splenectomy in a dog...
  99. ncbi Angiosarcoma after breast-conserving therapy: long-term outcomes with hyperfractionated radiotherapy
    Manisha Palta
    Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida 32610 0385, USA
    Cancer 116:1872-8. 2010
    ..The current study was conducted to report the long-term outcomes of a novel approach using hyperfractionated and accelerated radiotherapy (HART) for angiosarcoma developing after BCT...
  100. ncbi A rare case of thyroid haemangiosarcoma
    Paolo Del Rio
    Department of Surgical Science, Unit of General Surgery and Organ Transplantation, University of Parma, Via Gramsci, 14, 43100 Parma
    Chir Ital 59:747-9. 2007
    ..We present a case of epithelioid haemangiosarcoma in an elderly woman from outside the Alpine region with a contralateral papillary cancer treated by total thyroidectomy. The prognosis is poor and case reports are rare...
  101. pmc Establishment of canine hemangiosarcoma xenograft models expressing endothelial growth factors, their receptors, and angiogenesis-associated homeobox genes
    Atsushi Kodama
    Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Gifu University, Gifu, Japan
    BMC Cancer 9:363. 2009
    Human hemangiosarcoma (HSA) tends to have a poor prognosis; its tumorigenesis has not been elucidated, as there is a dearth of HSA clinical specimens and no experimental model for HSA...

Research Grants9

  1. Muscular Dystrophy Cooperative Research Center
    Jeffrey Chamberlain; Fiscal Year: 2007
    ..Finally, Core C (T Bird) is a genetic counseling core for patients and families with muscular dystrophy that will also allow increased participation of patients in studies of a variety of types of muscular dystrophy. ..
  2. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2009
    ..Specific Aim 3. To determine whether dysregulation of p16ink4a and PTCH (patched) acts as a modifier of theTS phenotype in transgenic mice expressing dominant negative tuberin. ..
  3. TRANSGLUTAMINASE PROMOTES CPPD DISEASE IN AGING JOINTS
    Ann Rosenthal; Fiscal Year: 2007
    ..These studies will contribute to our understanding of CPPD deposition disease, so that effective therapies for this common and disabling form of arthritis can be designed. ..
  4. Measure Validation and RCT- Dog Bone Cancer Pain Model
    Dorothy Brown; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  5. STI571 Therapy for Gastrointestinal Stromal Tumors
    Ronald DeMatteo; Fiscal Year: 2002
    ..The results are essential to advance our understanding of GIST biology and determine the therapeutic value and limitations of STI571. ..
  6. DYSTROPHIN REPLACEMENT IN MDX MICE
    Jeffrey Chamberlain; Fiscal Year: 2004
    ..These studies will provide new insights into both the structure of dystrophin and the mechanisms of dystrophic cell death and will help advance the development of gene therapy. ..
  7. Natural Killer Dendritic Cells in Listeria Infection
    Ronald DeMatteo; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  8. Matrix proteins promote matrix vesicle mineralization
    Ann Rosenthal; Fiscal Year: 2007
    ..The ultimate goal of this work is to understand the pathogenesis of calcium crystal formation in articular cartilage, so that specific therapies for this disabling disease can be designed. ..
  9. Functional and Tissue Specific Effects of VHL Mutations
    WENDY RATHMELL; Fiscal Year: 2007
    ..unreadable] [unreadable]..