hemangioendothelioma

Summary

Summary: A neoplasm derived from blood vessels, characterized by numerous prominent endothelial cells that occur singly, in aggregates, and as the lining of congeries of vascular tubes or channels. Hemangioendotheliomas are relatively rare and are of intermediate malignancy (between benign hemangiomas and conventional angiosarcomas). They affect men and women about equally and rarely develop in childhood. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1866)

Top Publications

  1. ncbi Infantile hepatic hemangioendothelioma with elevated serum alpha-fetoprotein
    Neriman Sari
    Hacettepe University, Institute of Oncology, Department of Pediatric Oncology, Ankara, Turkey
    Pediatr Hematol Oncol 23:639-47. 2006
  2. ncbi Hypervascular multifocal hepatoblastoma: dynamic gadolinium-enhanced MRI findings indistinguishable from infantile hemangioendothelioma
    Macy Lu
    Department of Medical Imaging, Royal Brisbane and Women s Hospital, Brisbane, Australia
    Pediatr Radiol 37:587-91. 2007
  3. ncbi β-Adrenergic receptor expression in vascular tumors
    Karen M Chisholm
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mod Pathol 25:1446-51. 2012
  4. ncbi Kaposiform hemangioendothelioma with Kasabach-Merritt syndrome: a new indication for propranolol treatment
    Denise Josephina Johanna Hermans
    Department of Dermatology, Radboud University Medical Centre, Nijmegen, The Netherlands
    J Pediatr Hematol Oncol 33:e171-3. 2011
  5. pmc Nox-4-dependent nuclear H2O2 drives DNA oxidation resulting in 8-OHdG as urinary biomarker and hemangioendothelioma formation
    Gayle Gordillo
    Division of Plastic Surgery, Department of Surgery, Davis Heart Lung Research Institute, The Ohio State University, Columbus, Ohio 43212, USA
    Antioxid Redox Signal 12:933-43. 2010
  6. ncbi Congenital composite hemangioendothelioma: case report and reappraisal of the hemangioendothelioma spectrum
    Jorge S Reis-Filho
    Institute of Molecular Pathology and Immunology, University of Porto IPATIMUP, Portugal
    J Cutan Pathol 29:226-31. 2002
  7. ncbi Retiform hemangioendothelioma: a case report and review of the literature
    Dongfeng Tan
    Department of Pathology and Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Cutan Pathol 32:634-7. 2005
  8. ncbi Mediastinal and neck kaposiform hemangioendothelioma: report of three cases
    Gráinne M O'Regan
    Department of Paediatric Dermatology, National Maternity Hospital, Dublin, Ireland
    Pediatr Dermatol 26:331-7. 2009
  9. ncbi Retiform hemangioendothelioma with lymph node metastasis: a rare entity
    Bhawna Bhutoria
    Department of Pathology, N R S Medical College, 138 AJC Bose Road, Kolkata 700 014, India
    Indian J Dermatol Venereol Leprol 75:60-2. 2009
  10. ncbi Kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon: successful treatment with embolization and vincristine in two newborns
    Ricardo Garcia-Monaco
    Vascular Anomalies Center, Hospital Italiano, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina
    J Vasc Interv Radiol 23:417-22. 2012

Detail Information

Publications203 found, 100 shown here

  1. ncbi Infantile hepatic hemangioendothelioma with elevated serum alpha-fetoprotein
    Neriman Sari
    Hacettepe University, Institute of Oncology, Department of Pediatric Oncology, Ankara, Turkey
    Pediatr Hematol Oncol 23:639-47. 2006
    Infantile hemangioendothelioma is the most common hepatic vascular tumor in infants less than 6 months of age, with a prevalence of 1%...
  2. ncbi Hypervascular multifocal hepatoblastoma: dynamic gadolinium-enhanced MRI findings indistinguishable from infantile hemangioendothelioma
    Macy Lu
    Department of Medical Imaging, Royal Brisbane and Women s Hospital, Brisbane, Australia
    Pediatr Radiol 37:587-91. 2007
    ..report we describe a neonate with multifocal hypervascular hepatoblastoma indistinguishable from infantile hemangioendothelioma on dynamic gadolinium-enhanced MRI...
  3. ncbi β-Adrenergic receptor expression in vascular tumors
    Karen M Chisholm
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mod Pathol 25:1446-51. 2012
    ..Absent to weak expression of all three receptors was seen in glomus tumor, hobnail hemangioendothelioma, pyogenic granuloma, and reactive vascular proliferations...
  4. ncbi Kaposiform hemangioendothelioma with Kasabach-Merritt syndrome: a new indication for propranolol treatment
    Denise Josephina Johanna Hermans
    Department of Dermatology, Radboud University Medical Centre, Nijmegen, The Netherlands
    J Pediatr Hematol Oncol 33:e171-3. 2011
    Kaposiform hemangioendothelioma is a rare vascular tumor in children. Especially, in association with the Kasabach-Merritt Phenomenon it can be life threatening...
  5. pmc Nox-4-dependent nuclear H2O2 drives DNA oxidation resulting in 8-OHdG as urinary biomarker and hemangioendothelioma formation
    Gayle Gordillo
    Division of Plastic Surgery, Department of Surgery, Davis Heart Lung Research Institute, The Ohio State University, Columbus, Ohio 43212, USA
    Antioxid Redox Signal 12:933-43. 2010
    ..In a murine model of hemangioendothelioma, we previously showed that MCP-1 is required for its development and that the expression of MCP-1 in EOMA ..
  6. ncbi Congenital composite hemangioendothelioma: case report and reappraisal of the hemangioendothelioma spectrum
    Jorge S Reis-Filho
    Institute of Molecular Pathology and Immunology, University of Porto IPATIMUP, Portugal
    J Cutan Pathol 29:226-31. 2002
    Composite hemangioendothelioma is the most recently described entity of the hemangioendothelioma (HE) spectrum. To the best of our knowledge, only eight cases of this entity have been hitherto described...
  7. ncbi Retiform hemangioendothelioma: a case report and review of the literature
    Dongfeng Tan
    Department of Pathology and Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Cutan Pathol 32:634-7. 2005
    Retiform hemangioendothelioma (RH) is a rare, recently described vascular neoplasm of low malignant potential.
  8. ncbi Mediastinal and neck kaposiform hemangioendothelioma: report of three cases
    Gráinne M O'Regan
    Department of Paediatric Dermatology, National Maternity Hospital, Dublin, Ireland
    Pediatr Dermatol 26:331-7. 2009
    Kaposiform hemangioendothelioma is an aggressive vascular tumor, named for its striking histologic resemblance to Kaposi sarcoma and locally invasive growth...
  9. ncbi Retiform hemangioendothelioma with lymph node metastasis: a rare entity
    Bhawna Bhutoria
    Department of Pathology, N R S Medical College, 138 AJC Bose Road, Kolkata 700 014, India
    Indian J Dermatol Venereol Leprol 75:60-2. 2009
    Retiform hemangioendothelioma (RH) is a rare, recently described, unique kind of low grade angiosarcoma. The tumor is characterized by distinctive arborizing blood vessels that mimic the appearance of rete testis...
  10. ncbi Kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon: successful treatment with embolization and vincristine in two newborns
    Ricardo Garcia-Monaco
    Vascular Anomalies Center, Hospital Italiano, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina
    J Vasc Interv Radiol 23:417-22. 2012
    Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor and has a high mortality in newborns when associated with Kasabach-Merritt syndrome (KMS)...
  11. pmc A case of retiform-hemangioendothelioma with unusual presentation and aggressive clinical features
    Guiying Zhang
    Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
    Int J Clin Exp Pathol 3:528-33. 2010
    Retiform hemangioendothelioma (RH) is an extremely rare low-grade angiosarcoma mainly involving the skin and subcutaneous tissue. Clinically patients often present with an asymptomatic slow-growing solitary nodular or plaque-like lesion...
  12. ncbi Hemangioendothelioma
    Luis Requena
    Department of Dermatology, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain
    Semin Diagn Pathol 30:29-44. 2013
    b>Hemangioendothelioma is the term used to name those vascular neoplasms that show a borderline biological behavior, intermediate between entirely benign hemangiomas and highly malignant angiosarcomas...
  13. ncbi Pseudomyogenic hemangioendothelioma: a distinctive, often multicentric tumor with indolent behavior
    Jason L Hornick
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 35:190-201. 2011
    ..Although the precise nosologic status of this tumor type is uncertain, we propose the interim designation "pseudomyogenic hemangioendothelioma."
  14. ncbi Successful treatment of retroperitoneal infantile hemangioendothelioma with Kasabach-Merritt syndrome using steroid, alpha-interferon, and vincristine
    Hoi Soo Yoon
    Department of Pediatrics, Kyung Hee University Medical Center, Seoul, Korea
    J Pediatr Hematol Oncol 31:952-4. 2009
    Infantile hemangioendothelioma (IHE) is a rare benign vascular tumor with potentially life-threatening complications. Various therapeutic options have been recommended according to the site, extent, and behavior of the IHE...
  15. pmc Targeting of beta adrenergic receptors results in therapeutic efficacy against models of hemangioendothelioma and angiosarcoma
    Jessica M Stiles
    Department of Biomedical Sciences, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA
    PLoS ONE 8:e60021. 2013
    ..Using a panel of hemangioendothelioma and angiosarcoma cell lines, we demonstrate that beta adrenergic inhibition blocks cell proliferation and ..
  16. ncbi Efficacy and safety of propranolol in the treatment of parotid hemangioma
    Paulo Morais
    Department of Dermatovenereology, Hospital S Joao, EPE, University of Porto, Faculty of Medicine, Porto, Portugal
    Cutan Ocul Toxicol 30:245-8. 2011
    ..Additionally, hepatic ultrasonography revealed a hemangioendothelioma located at right lobe...
  17. pmc Variable response to propranolol treatment of kaposiform hemangioendothelioma, tufted angioma, and Kasabach-Merritt phenomenon
    Yvonne E Chiu
    Department of Dermatology, Division of Pediatric Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Pediatr Blood Cancer 59:934-8. 2012
    Propranolol is a non-selective beta-adrenergic antagonist successfully used in a case of kaposiform hemangioendothelioma (KHE) associated with Kasabach-Merritt phenomenon (KMP)...
  18. ncbi Treatment of hepatic epithelioid hemangioendothelioma: a single-institution experience with 25 cases
    Jon Cardinal
    Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Arch Surg 144:1035-9. 2009
    To examine treatment of hepatic epithelioid hemangioendothelioma (EHE), a rare vascular tumor with a variable course. Treatment modalities at our institution include liver resection, transplantation, and catheter-based therapies.
  19. ncbi Long-term outcomes following liver transplantation for hepatic hemangioendothelioma: the UNOS experience from 1987 to 2005
    Joel A Rodriguez
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, 1709 Dryden, Suite 15 37, Houston, Texas 77030, USA
    J Gastrointest Surg 12:110-6. 2008
    Hepatic hemangioendothelioma (HEH) is a vascular neoplasm with intermediate malignant potential. Outcomes after liver transplantation have only been reported as small, single-institution experiences...
  20. ncbi [Malignant epithelioid hemangioendothelioma of the liver. Results of surgical treatment strategies]
    J M Langrehr
    Klinik fUr Allgemein, Viszeral und Transplantationschirurgie, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin
    Chirurg 76:1161-7. 2005
    Malignant epithelioid hemangioendothelioma is a rare vascular tumor described mostly in soft tissue, lungs, or liver...
  21. ncbi Successful management of Kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon using vincristine and ticlopidine
    Veronica Lopez
    Department of Dermatology, Hospital Clinico Universitario de Valencia, Valencia, Spain
    Pediatr Dermatol 26:365-6. 2009
    Kaposiform hemangioendothelioma is a rare locally aggressive vascular tumor that usually occurs in skin and retroperitoneum of infants and young children...
  22. ncbi Masson's vegetant hemangioendothelioma: case report and literature review
    Michael R Stoffman
    Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA
    J Neurooncol 61:17-22. 2003
    Masson's vegetant intravascular hemangioendothelioma has only been reported intracranially in 12 patients. The pathological diagnosis is important given its benign natural history...
  23. ncbi Successful treatment of kaposiform hemangioendothelioma and tufted angioma with vincristine
    Farzan Fahrtash
    Department of Pediatrics and Child Health, The University of Sydney, Sydney, New South Wales, Australia
    J Pediatr Hematol Oncol 32:506-10. 2010
    Kaposiform hemangioendothelioma (KHE) and tufted angioma (TA) are rare, locally aggressive vascular tumors. Although currently classified as separate entities, they are becoming increasingly recognized as a spectrum of the same pathology...
  24. ncbi Estrogen and progesterone receptors in lymphangioleiomyomatosis, epithelioid hemangioendothelioma, and sclerosing hemangioma of the lung
    N P Ohori
    Department of Pathology, Presbyterian University Hospital, University of Pittsburgh School of Medicine, Pennsylvania
    Am J Clin Pathol 96:529-35. 1991
    ..g., breast). However, two mesenchymal proliferations of lung, lymphangioleiomyomatosis and epithelioid hemangioendothelioma (EHE), and one epithelial tumor, sclerosing hemangioma (SH), have a significant female predilection and may ..
  25. ncbi Clinical experience with infantile hepatic hemangioendothelioma
    Suk Bae Moon
    Department of Pediatric Surgery, Seoul National University Children s Hospital, 28 Yongon Dong, Chongno Ku, Seoul 110 744, South Korea
    World J Surg 33:597-602. 2009
    Infantile hepatic hemangioendothelioma (IHHE) is a rare disorder with only a few series reported in the medical literature. We reviewed our treatment experience with IHHE over 17 years.
  26. ncbi Infantile hepatic hemangioendothelioma: clinical presentation and treatment
    Betul Sevinir
    Department of Pediatric Oncology, Uludag University, School of Medicine, Bursa
    Turk J Gastroenterol 18:182-7. 2007
    ..Hepatic hemangioendotheliomas are rare tumors in childhood. We report our 10-years' experience in a tertiary health center...
  27. ncbi A case of head and neck kaposiform hemangioendothelioma simulating a malignancy on imaging
    T A Lalaji
    Department of Radiology, Long Island College Hospital, 339 Hicks Street, Brooklyn, NY 11201, USA. TALalaji @aol.com
    Pediatr Radiol 31:876-8. 2001
    Kaposiform hemangioendothelioma (KH) is an endothelial-derived spindle cell neoplasm often associated with Kasabach-Merritt syndrome. Most cases arise in infancy and childhood and are soft-tissue tumors...
  28. ncbi Hepatic hemangioendothelioma in children: analysis of thirteen cases
    Chien Chang Chen
    Department of Gastroenterology, Chang Gung Children s Hospital, No 5, Fu Hsin Street, Kuei Shan, Taoyuan, Taiwan
    Acta Paediatr Taiwan 44:8-13. 2003
    Hepatic hemangioendothelioma (HE) is a tumor that presents in infancy and toddler. It manifests hepatomegaly, abdominal mass, jaundice, abdominal distention, or high output cardiac failure...
  29. ncbi Infantile hemangioendothelioma: A case report and discussion
    R Ganguly
    Department of Pathology, The Mission Hospital, Durgapur, Sector 2C, Immon Kalyan Sarani, Durgapur 713212, India
    Pathol Res Pract 206:53-8. 2010
    ..The patient had no skin lesions. We report this case and provide a literature review because of the unusual presentation and the overall rarity of this entity...
  30. ncbi Composite hemangioendothelioma: report of 5 cases including one with associated Maffucci syndrome
    Masaharu Fukunaga
    Department of Pathology, The Jikei University School of Medicine, Jikei Daisan Hospital, 4 11 1 Izumihoncho, Komaeshi, Tokyo 201 8601, Japan
    Am J Surg Pathol 31:1567-72. 2007
    Composite hemangioendothelioma (HE) is a low-grade malignant vascular tumor showing varying combinations of benign, low-grade malignant, and malignant vascular components...
  31. ncbi Vincristine and corticosteroids as first-line treatment of Kasabach-Merritt syndrome in kaposiform hemangioendothelioma
    Aaron M Drucker
    Department of Paediatrics and Paediatric Dermatology, The Hospital for Sick Children, University of Toronto, Toronto, ON
    J Cutan Med Surg 13:155-9. 2009
    ..Recently, there have been increasing reports of the use of the chemotherapeutic drug vincristine in these patients...
  32. ncbi Kaposiform hemangioendothelioma arising in the ethmoid sinus of an 8-year-old girl with severe epistaxis
    Manfred T Birchler
    Department of Otolaryngology, University Children s Hospital Zurich, Switzerland
    Head Neck 28:761-4. 2006
    ..It occurs primarily in boys and is usually self-limiting. Trauma and nose picking are among the most common causes. In general, epistaxis can be easily treated with anterior nasal packing or electrocoagulation...
  33. ncbi Infantile hemangioendothelioma with elevated serum alpha fetoprotein: report of 2 cases with immunohistochemical analysis
    Tae Jung Kim
    Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, 150 713 Seoul, Korea
    Hum Pathol 41:763-7. 2010
    Infantile hemangioendothelioma is the most common benign mesenchymal tumor of the liver presenting during the first 6 months of life...
  34. ncbi Infantile hepatic hemangioendothelioma presenting as early heart failure: report of two cases
    Chung Ching Lu
    Department of Pediatrics, Chang Gung Children s Hospital, Kaohsiung, Taiwan, ROC
    Chang Gung Med J 25:405-10. 2002
    Hepatic hemangioendothelioma is rare. We report on hepatic hemangioendotheliomas in 2 young infants, with initial manifestations of respiratory distress and congestive heart failure...
  35. ncbi Hepatic infantile hemangioendothelioma with unusual manifestations
    Matthew R Riley
    Division of Pathology, Stanford University Medical Center, California 94304, USA
    J Pediatr Gastroenterol Nutr 42:109-13. 2006
  36. pmc Infantile hemangioendothelioma treated with high dose methylprednisolone pulse therapy
    E A Park
    Department of Pediatric, College of Medicine, Ewha Womans University, Seoul, Korea
    J Korean Med Sci 16:127-9. 2001
    Infantile hemangioendothelioma is a severe disease with a high mortality. It is characterized by multiple hemangioma affecting the skin and visceral organs...
  37. ncbi Kaposiform hemangioendothelioma: a study of 33 cases emphasizing its pathologic, immunophenotypic, and biologic uniqueness from juvenile hemangioma
    Lisa L Lyons
    Departments of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Surg Pathol 28:559-68. 2004
    Kaposiform hemangioendothelioma (KH) is a rare tumor of childhood often associated with Kasabach-Merritt phenomenon (KMP) and occasionally lymphangiomatosis...
  38. ncbi Magnetic resonance imaging of infantile hemangioendothelioma
    Ahmet Mesrur Halefoglu
    Department of Radiology, Sisli Etfal Training and Research Hospital, Istanbul, Turkey
    Turk J Pediatr 49:77-81. 2007
    Infantile hemangioendothelioma is the most common benign hepatic tumor during infancy and also follows a benign course. During the routine physical examination of a 10-month-old female patient, masses of the liver were incidentally found...
  39. ncbi Retroperitoneal kaposiform hemangioendothelioma with tufted angioma-like features in an infant with Kasabach-Merritt syndrome
    Dimitrije Brasanac
    Institute of Pathology, School of Medicine, University of Belgrade, Belgrade, Serbia and Montenegro
    Pathol Int 53:627-31. 2003
    ..Histological examination revealed a combination of venous (cavernous) malformation, kaposiform hemangioendothelioma and tufted angioma-like areas...
  40. ncbi Kaposiform hemangioendothelioma associated with nonimmune fetal hydrops
    Antonio E Martinez
    Arkadi M Rywlin MD Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, Fla 33140, USA
    Arch Pathol Lab Med 128:678-81. 2004
    We describe the case of a 31-week fetus who died in utero with an invasive retroperitoneal kaposiform hemangioendothelioma. This rare vascular neoplasm usually presents as a localized violaceous skin lesion in infants and behaves in a ..
  41. ncbi Successful multimodal therapy for kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon: case report and review of the literature
    F Blei
    Department of Pediatrics, NYU Medical Center, New York 10016, USA
    Pediatr Hematol Oncol 15:295-305. 1998
    We present the management challenge provided by a patient with kaposiform hemangioendothelioma associated with Kasabach-Merritt phenomenon...
  42. ncbi Metastasizing splenic littoral cell hemangioendothelioma
    Susan Fernandez
    Department of Pathology, Stanford University, Stanford, CA 94305, USA
    Am J Surg Pathol 30:1036-40. 2006
    ..A single prior description of a littoral cell hemangioendothelioma showed nuclear atypia and necrosis, and this is the first case report of a splenic littoral cell ..
  43. ncbi Endoscopic treatment of ethmoidal hemangioendothelioma: case report and review of the literature
    Lucia Semino
    ENT Department, University of Pavia, IRCCS Policlinico S Matteo, 27100 Pavia, Italy
    Am J Otolaryngol 27:287-90. 2006
    b>Hemangioendothelioma (HE) is a rare vascular tumor of endothelial cell origin that usually involves long bone or soft tissue. However, there are cases of head and neck involvement...
  44. ncbi Hemangioendothelioma of the temporal bone with radiologic findings resembling hemangioma
    R A Ibarra
    Department of Radiology, University of Texas Health Science Center at San Antonio, 78229, USA
    AJNR Am J Neuroradiol 22:755-8. 2001
    ..Only four cases have been reported involving the temporal bone. A 5-year-old child with grade II hemangioendothelioma of the right temporal bone is presented, and the radiologic findings on different imaging studies are ..
  45. ncbi Epithelioid hemangioendothelioma of the spine presenting as cervical myelopathy: case report
    J W Brennan
    Department of Surgery, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Ontario, Canada
    Neurosurgery 48:1166-9. 2001
    ..in the literature of cervical myelopathy caused by progressive cord compression as a result of epithelioid hemangioendothelioma of the cervical vertebra...
  46. ncbi Hepatic hemangioendothelioma associated with production of humoral thyrotropin-like factor
    R M Ayling
    Department of Clinical Biochemistry, King's College Hospital, Denmark Hill, London SE5 9RS, United Kingdom
    J Pediatr 138:932-5. 2001
    We report on 7 patients referred for treatment of hepatic hemangioendothelioma with increased thyrotropin levels. The serum thyroxine level was decreased in 4 and increased in 2...
  47. ncbi Angiomotin expression promotes hemangioendothelioma invasion
    Tetyana Levchenko
    Department of Oncology Pathology, Cancer Centre Karolinska Institute, S 17176, Stockholm, Sweden
    Oncogene 23:1469-73. 2004
    ..However, time-lapse photography showed a significant increase in random motility in MAE-Amot cells. We conclude that angiomotin may promote angiogenesis by both stimulating invasion as well as stabilizing established tubes...
  48. ncbi Thyroid abnormalities in infantile hepatic hemangioendothelioma
    Ram Kalpatthi
    Division of Pediatric Hematology Oncology, Children s Hospital, Columbus, Ohio 43205, USA
    Pediatr Blood Cancer 49:1021-4. 2007
    We report an infant with hepatic hemangioendothelioma (HAE) associated with compensated hypothyroidism. The hepatic lesions regressed with steroid therapy and his thyroid function normalized with high doses of thyroxine supplement.
  49. ncbi Kaposiform hemangioendothelioma: five patients with cutaneous lesion and long follow-up
    F Mac-Moune Lai
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China SAR
    Mod Pathol 14:1087-92. 2001
    Kaposiform hemangioendothelioma is a rare locally aggressive vascular tumor of the skin, deep soft tissue, and bone in children, characterized by infiltrating nodules and sheets of spindle cells, and unmistakable resemblance to Kaposi's ..
  50. ncbi Hemangioendothelioma of the spinal cord with intramedullary extension
    S Abuzallouf
    Department of Radiation Oncology, Hamilton Regional Cancer Centre, Hamilton, Canada
    Med Princ Pract 14:354-7. 2005
    ..The tumor was resected and postoperative radiotherapy was delivered for residual disease. No disease was seen on MRI after 48 months of clinical and radiological follow-up...
  51. ncbi Retiform hemangioendothelioma presenting as bruise-like plaque in an adult woman
    Despina Ioannidou
    Department of Dermatology, Heraklion University General Hospital, Heraklion, Crete, Greece
    Int J Dermatol 45:53-5. 2006
  52. ncbi Symptomatic hepatic hemangioendothelioma in a newborn
    K Jothilakshmi
    Department of Pediatrics, P S G Institute of Medical Sciences and Research, Peelamedu, Coimbatore 641 004, Tamil Nadu, India
    Indian Pediatr 43:908-10. 2006
    A case of hepatic hemangioendothelioma presenting as congestive cardiac failure in a neonate is reported. There was also evidence of platelet consumption...
  53. ncbi Severe hypothyroidism caused by hepatic hemangioendothelioma in an infant of a diabetic mother
    Ayla Guven
    Division of Endocrinology, Department of Pediatrics, Medical Faculty, Ondokuz Mayis University, TR 55200 Samsun, Turkey
    Horm Res 63:86-9. 2005
    ..Here we report an infant of a diabetic mother with hypothyroidism caused by liver hemangioendothelioma. Consumptive hypothyroidism should be an indicator to search for a vascular tumor in infants...
  54. ncbi Resolution of medically resistant hypothyroidism after liver transplantation for hepatic hemangioendothelioma
    Timothy C Lee
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
    J Pediatr Surg 41:1783-5. 2006
    Hepatic hemangioendothelioma (HHE) is a rare vascular tumor in neonates and may cause high-output cardiac failure and coagulopathy, and rarely has been associated with hypothyroidism...
  55. ncbi Kaposiform haemangioendothelioma: case report and review of the literature
    J G Cooper
    Department of Plastic Surgery, Aberdeen Royal Infirmary, Aberdeen, UK
    Br J Plast Surg 55:163-5. 2002
    ..We report an otherwise well 26-year-old woman who presented with a KHE of the left thigh, and briefly review the literature. We believe this to be the second reported case of KHE in the UK and the first in an adult patient...
  56. ncbi Rapid resolution of consumptive hypothyroidism in a child with hepatic hemangioendothelioma following liver transplantation
    Andrea E Balazs
    Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Ann Clin Lab Sci 37:280-4. 2007
    We report a unique case of a 3-mo-old female with consumptive hypothyroidism and liver hemangioendothelioma who required pharmacological doses of thyroid hormones and was cured following liver transplantation...
  57. ncbi A key angiogenic role of monocyte chemoattractant protein-1 in hemangioendothelioma proliferation
    Gayle M Gordillo
    Division of Plastic Surgery, The Ohio State University Medical Center, 410 W 10th Ave, Columbus, OH 43210, USA
    Am J Physiol Cell Physiol 287:C866-73. 2004
    ..This study has produced the first in vivo evidence of a complete response for any neoplasm, specifically a vascular proliferative lesion, to anti-MCP-1 therapy in animals with intact immune systems...
  58. ncbi Interventional treatment of infantile hepatic hemangioendothelioma
    S Warmann
    Department of Pediatric Surgery, University of Tubingen, Tubingen, Germany
    J Pediatr Surg 38:1177-81. 2003
    b>Hemangioendothelioma is the most frequent liver tumor in infancy. Untreated symptomatic patients with heart failure have a high mortality rate...
  59. ncbi Solitary hepatic infantile hemangioendothelioma: dynamic gadolinium-enhanced MR imaging findings
    Koenraad J Mortele
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Eur Radiol 12:862-5. 2002
    We report the MRI findings of a solitary hepatic infantile hemangioendothelioma (IHE) diagnosed in a 14-day-old girl...
  60. ncbi Hemangioendothelioma: successful therapy with interferon-alpha: a study in Association with the Italian Pediatric Haematology/Oncology Society (AIEOP)
    Giovanni Deb
    Divisione di Oncologia, Ospedale Pediatrico Bambino Gesù Roma, Italy
    Med Pediatr Oncol 38:118-9. 2002
  61. ncbi A case of axillary kaposiform hemangioendothelioma resembles a soft tissue sarcoma
    Chih Cheng Hsiao
    Department of Pediatric Hematology and Oncology, Chang Gung Memorial Hospital, Kaohsiung, and Graduate Institute of Clinical Medical Sciences, Chang Gung University, Linko, Taiwan
    J Pediatr Hematol Oncol 27:596-8. 2005
    Kaposiform hemangioendothelioma is a rare, aggressive vascular proliferation in children that is clinically and histologically distinct from hemangioma of infancy. It is often complicated with Kasabach-Merritt syndrome...
  62. ncbi Infantile haemangio-endothelioma of liver: a case report
    Sapna Singh
    Department of Radiodiagnosis, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi
    J Indian Med Assoc 106:120, 122. 2008
    ..A postcontrast CT revealed intense enhancement of all the lesions. The findings suggested an infantile haemangio-endothelioma of the liver. On follow-up USG after 8 months near complete involution of the mass was revealed...
  63. pmc Kaposiform hemangioendothelioma with distant lymphangiomatosis without an association to Kasabach-Merritt-Syndrome in a female adult!
    Claudia S Vetter-Kauczok
    Department of Dermatology, Julius Maximilians University Wuerzburg, Wuerzburg, Germany
    Vasc Health Risk Manag 4:263-6. 2008
    Kaposiform hemangioendothelioma (KHE) is a locally aggressive vascular tumor which usually occurs in infants. Clinically it appears as ill-defined red to purple indurated plaque...
  64. ncbi Atypical imaging findings of infantile hemangioendothelioma: a case report
    E Mavili
    Department of Radiology, Erciyes University Medical Faculty, Kayseri, Turkey
    Acta Radiol 47:1091-3. 2006
    Infantile hemangioendothelioma is the third most common hepatic tumor in children, and the most common benign vascular tumor of the liver in infancy...
  65. ncbi Undifferentiated (sarcomatous) carcinoma of the liver with osteoclast-like giant cells presenting as tumor thrombus in the inferior vena cava
    Hans Ulrich Schildhaus
    Virchows Arch 448:659-60. 2006
  66. ncbi A series of vascular tumors and tumorlike lesions of the bladder
    Fabio Tavora
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 32:1213-9. 2008
    ..hyperplasias (Masson vegetant hemangioendotheliomas), 2 arteriovenous malformations (AVMs), 1 epithelioid hemangioendothelioma (EHE), and 4 angiosarcomas...
  67. ncbi [Infantile hepatic hemangioendothelioma. A multifocal, bilobular and asymptomatic case with spontaneous regression]
    A R Araújo
    Servicio de Pediatria, Centro Hospitalar do Alto Minho, Viana do Castelo, Portugal
    An Pediatr (Barc) 68:507-10. 2008
    Infantile hepatic hemangioendothelioma is a severe disease with a high mortality rate. Nevertheless these vascular lesions may experience spontaneous regression within 12 to 18 months...
  68. ncbi Cutaneous vascular tumours: an update
    S G N Goh
    St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Histopathology 52:661-73. 2008
    ..The newly introduced clinical classification of congenital haemangiomas into non-involuting and rapidly involuting variants and radiation-induced atypical vascular lesions are also reviewed...
  69. ncbi Practical review and recent developments in pediatric dermatopathology
    Lydia R Essary
    Clinical Assistant Professor of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Adv Dermatol 21:193-215. 2005
  70. ncbi Childhood hepatic angiosarcoma--a case report
    C S Premalata
    Department of Pathology, Kidwai Memorial Institute of Oncology, M H Marigowda Road, Bangalore
    Indian J Pathol Microbiol 48:487-9. 2005
    ..Histopathological examination revealed features typical of hepatic angiosarcoma. The case is presented for its rarity and to discuss the interrelation between infantile hemangioendothelioma (IHE) and HAS.
  71. ncbi Usefulness of D2-40 immunohistochemistry for differentiation between kaposiform hemangioendothelioma and tufted angioma
    Eiichi Arai
    Department of Pathology, Saitama Medical School, Iruma gun, Saitama, Japan
    J Cutan Pathol 33:492-7. 2006
    ..D2-40 immunohistochemistry, the differences among capillary hemangiomas, and especially between kaposiform hemangioendothelioma (KHE) and tufted angioma (TA)...
  72. pdf Hepatic hemangloendothelioma: the need for early diagnosis and resection
    Hussein Shamaly
    Pediatric Gastroenterology Unit, French Hospital, Nazareth, Israel
    Isr Med Assoc J 8:585-6. 2006
  73. ncbi Kaposiform hemangioendothelioma in an adult with an unusual presentation
    N Senturk
    J Eur Acad Dermatol Venereol 20:630-2. 2006
  74. ncbi [Congenital haemangiomas and other rare infantile vascular tumours]
    O Enjolras
    Consultations des angiomes, service du Professeur Marie Paule Vazquez, Hopital d Enfants Armand Trousseau, INSERM U714, Universite Paris VI, Assistance Publique Hopitaux de Paris, 75571 Paris Cedex 12, France
    Ann Chir Plast Esthet 51:339-46. 2006
    ..However they may occur as isolated tumours, without thrombocytopenia but with cosmetic, and sometimes function-impairing, consequences...
  75. ncbi Recurrent life-threatening hemothorax in an infant with pleurocutaneous kaposiform hemangio-endothelioma
    Rong Long Chen
    J Pediatr Hematol Oncol 28:630-2. 2006
  76. ncbi Malignant vascular tumors of liver in neonates
    Zafar Nazir
    Department of Surgery, The Aga Khan University Hospital AKUH, Karachi 74800, Pakistan
    J Pediatr Surg 41:e49-51. 2006
    ..We report two cases. One was initially diagnosed as infantile hemangioendothelioma. Rapid growth and appearance of pulmonary metastasis while on aggressive medical treatment suggested ..
  77. ncbi [Infantile hemangiomas: differential diagnosis and associated anomalies]
    A Dompmartin
    Service de Dermatologie, Centre Hospitalier Universitaire de Caen, Avenue Georges Clemenceau, 14033 Caen Cedex, France
    Ann Chir Plast Esthet 51:300-9. 2006
    ..Knowledge on differential diagnosis enables clinicians to detect hemangiomas that can lead to complications and that necessitate a multidisciplinary approach...
  78. ncbi Vascular tumors of infancy and childhood: beyond capillary hemangioma
    Paula E North
    Department of Pathology, Medical College of Wisconsin and Children s Hospital of Wisconsin, Milwaukee, WI 53226, USA
    Cardiovasc Pathol 15:303-17. 2006
    ....
  79. ncbi Extravascular papillary endothelial hyperplasia of the palm masquerading as an angiosarcoma
    Eiichi Arai
    Department of Pathology, Saitama Medical University, Moroyama machi, Iruma gun, Saitama, Japan
    J Dermatol 35:238-41. 2008
    ..To our knowledge, cutaneous extravascular PEH has not yet been reported in the published work...
  80. ncbi Abdominal plaque in a 10-day-old boy
    Ernest Lee
    Indiana University School of Medicine, Indianapolis, USA
    Arch Dermatol 142:641-6. 2006
  81. ncbi Kaposiform hemangioendothelioma: the first reported case in a nonhuman animal species
    Mattie J Hendrick
    Vet Pathol 42:518. 2005
  82. ncbi Case report: infantile hemangioendothelioma
    Jeanne P Zenge
    Department of Pediatrics, Section of Neonatology, University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado, USA
    Curr Opin Pediatr 14:99-102. 2002
    ..Histopathologic examination revealed a type I infantile hemangioendothelioma. This case report reviews the presentation and treatment of infantile hemangioendotheliomas and the ..
  83. ncbi Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 13-2004. A newborn girl with a large cutaneous lesion, thrombocytopenia, and anemia
    John B Mulliken
    Division of Plastic Surgery, Craniofacial Center, and Vascular Anomalies Center, Children s Hospital, Boston, USA
    N Engl J Med 350:1764-75. 2004
  84. ncbi Case of large placental chorioangioma associated with diffuse neonatal hemangiomatosis
    Sevgi Bakaris
    Department of Pathology, KSU Medical School, 46050, Kahramanmaras, Turkey
    Pediatr Dev Pathol 7:258-61. 2004
    ..01 to 1.3%. Vascular anomalies of the placenta coincidental with infantile hemangioendothelioma (IH) of the liver are rarely described...
  85. ncbi Utility of the immunohistochemical detection of FLI-1 expression in round cell and vascular neoplasm using a monoclonal antibody
    Sabrina Rossi
    Department of Pathology, Regional Hospital, Treviso, Italy
    Mod Pathol 17:547-52. 2004
    ....
  86. ncbi Infantile hemangioendothelioma
    Justus E Roos
    Institute of Diagnostic Radiology, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Radiographics 23:1649-55. 2003
  87. ncbi Splenic vascular tumors
    Jeffery L Kutok
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Semin Diagn Pathol 20:128-39. 2003
    ..This overview describes the diagnosis and differential diagnosis of splenic vascular tumors as presently understood...
  88. ncbi Malignant vascular tumors in children and adolescents: a report from the Italian and German Soft Tissue Sarcoma Cooperative Group
    Andrea Ferrari
    Istituto Nazionale Tumori, Via G Venezian 1, Milano MI, Italy
    Med Pediatr Oncol 39:109-14. 2002
    ..We report on a series of 18 children who had malignant vascular tumors, treated from 1980 to 2000 by the Italian and German Soft Tissue Sarcoma Cooperative Group...
  89. ncbi Benign hepatic tumours
    E Biecker
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Bonn
    Z Gastroenterol 41:191-200. 2003
    ..Bile duct adenoma is an incidental finding that is not known to cause any symptoms whereas biliary cystadenoma is often symptomatic and may progress to cystadenocarcinoma and therefore needs resection...
  90. ncbi [Prenatal diagnosis of hepatic hemangioendothelioma and peripartual management]
    S Ritter
    Frauenklinik für Gynäkologie und Geburtshilfe der Rheinisch Westfälischen Technischen Hochschule Aachen, Abteilung Ultraschall und Pränataldiagnostik
    Z Geburtshilfe Neonatol 207:29-32. 2003
    Infantile hepatic hemangioendothelioma is a benign hepatic tumor that can be associated with life-threatening perinatal complications. A 38-year-old gravida 3 para 2 was referred to our hospital with preterm labor at 33...
  91. ncbi Endothelial lesions of soft tissues: a review of reactive and neoplastic entities with emphasis on low-grade malignant ("borderline") vascular tumors
    Carolyn D O'Hara
    Department of Laboratory Medicine and Pathalogy, Mayo Clinic, Rochester, Minnesota 55905, USA
    Adv Anat Pathol 10:69-87. 2003
    ..In addition, many tumor-like lesions containing an endothelial component are also discussed...
  92. ncbi Endothelial cell tumors
    Cecil David Bell
    Division of Anatomical Pathology, St Michael s Hospital, Toronto M5B 1W8, Canada
    Microsc Res Tech 60:165-70. 2003
    ....
  93. ncbi Vincristine--an effective treatment of corticoid-resistant life-threatening infantile hemangiomas
    Jaime Perez
    Department of Pediatrics, Son Dureta University Hospital, Palma de Mallorca, Spain
    Acta Oncol 41:197-9. 2002
  94. ncbi The role of GLUT1 immunostaining in the diagnosis and classification of liver vascular tumors in children
    Francisco Hernandez
    Department of Pediatric Surgery, Hospital Universitario La Paz, 28046 Madrid, Spain
    J Pediatr Surg 40:801-4. 2005
    ..To improve therapeutic strategies, we designed this study in which we tested in pathology specimens of LVT the hypothesis that GLUT1 expression could be useful to understand and classify LVT...
  95. ncbi Vascular anomalies: From bedside to bench and back again
    Francine Blei
    Department of Pediatrics, New York University School of Medicine, Kaplan Cancer Center, General Clinical Research Center, Hassenfeld Children s Center for Cancer and Blood Disorders, New York, New York, USA
    Curr Probl Pediatr Adolesc Health Care 32:72-93. 2002
  96. ncbi Absence of HHV-8 DNA in hobnail hemangiomas
    Ralf Gutzmer
    Department of Dermatology and Allergology, Hannover Medical University, Hannover, Germany
    J Cutan Pathol 29:154-8. 2002
    ..is a rare subtype of hemangioma that shares the morphological feature of hobnail endothelia with retiform hemangioendothelioma (RHE) and has to be considered in the differential diagnosis of Kaposi sarcoma...
  97. ncbi Malignant liver tumors
    Angela D Levy
    Department of Radiologic Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Clin Liver Dis 6:147-64. 2002
    ..Many [figure: see text] of these neoplasms have distinctive imaging features that may permit diagnosis. In most instances, however, biopsy is required for definitive diagnosis and treatment planning...
  98. ncbi Congenital hepatic shunts
    Carmen Gallego
    Department of Radiology, Hospital Universitario 12 de Octubre, Carretera de Andalucia Km 5, 400, 28041 Madrid, Spain
    Radiographics 24:755-72. 2004
    ..Familiarity with the US features of various congenital abnormal hepatic vascular connections will aid in diagnosis and treatment...
  99. ncbi Multifocal lymphangioendotheliomatosis with thrombocytopenia: a newly recognized clinicopathological entity
    Paula E North
    Departments of Pathology and Otolaryngology, the University of Arkansas for Medical Sciences and Arkansas Children s Hospital, Little Rock, AR 72202, USA
    Arch Dermatol 140:599-606. 2004
    Severe thrombocytopenic coagulopathy may complicate platelet-trapping vascular tumors such as kaposiform hemangioendothelioma and tufted angioma...
  100. ncbi Epithelioid hemangioendothelioma of the liver: radiologic-pathologic correlation
    K Mermuys
    Department of Radiology, Onze Lieve Vrouwe Hospital Aalst, Moorselbaan 164, 9300 Aalst, Belgium
    Abdom Imaging 29:221-3. 2004
    Epithelioid hemangioendothelioma of the liver is a rare vascular tumor with intermediate malignant potential. On imaging studies, the lesion has a solid appearance and may mimic metastatic disease...
  101. ncbi USCAP Specialty Conference: case 3
    Cheryl M Coffin
    Department of Pathology, Division of Pediatric Pathology, Primary Children s Hospital, 100 North Medical Drive, Salt Lake City, UT 84113 1100, USA
    Pediatr Dev Pathol 8:74-6. 2005

Research Grants9

  1. Mechanisms Regulating Hemangioendothelioma: A Plastic Surgeon's Challenge
    Gayle M Gordillo; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): The overall objective of this proposal entitled, "Mechanisms Regulating Hemangioendothelioma: A Plastic Surgeon's Challenge", is to determine how nox-4 regulates the growth of endothelial cells ..
  2. Interdisciplinary Workshop on Vascular Anomalies Associated with Coagulopathies
    Michael E Kelly; Fiscal Year: 2011
    ..and scientists focusing on two vascular anomalies associated with high morbidity and mortality, Kaposiform hemangioendothelioma (KHE) and multifocal lymphangioendotheliomatosis with thrombocytopenia (MLT)...
  3. PATHOPHYSIOLOGY OF CUTANEOUS VASCULAR LESIONS
    Jack Arbiser; Fiscal Year: 2002
    ..Finally, the novel angiogenesis inhibitor endostatin has been isolated from a spontaneous hemangioendothelioma cell line. Its mechanism of action is unknown...
  4. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2009
    ..Specific Aim 3. To determine whether dysregulation of p16ink4a and PTCH (patched) acts as a modifier of theTS phenotype in transgenic mice expressing dominant negative tuberin. ..
  5. Role of macrophages in hemangioendothelioma development
    Gayle Gordillo; Fiscal Year: 2008
    Hemangiomas represent the most common soft tissue tumor in children and hemangioendothelioma (HE) are a clinical subtype. Proliferating HE are associated with macrophage infiltration and MCP-1 expression...
  6. STI571 Therapy for Gastrointestinal Stromal Tumors
    Ronald DeMatteo; Fiscal Year: 2002
    ..The results are essential to advance our understanding of GIST biology and determine the therapeutic value and limitations of STI571. ..
  7. Gene Ratios for Lung Cancer Detection and Prognosis
    Raphael Bueno; Fiscal Year: 2004
    ..We envision that our methodology will be adaptable to a future clinical scenario where each suspicious nodule would be evaluated by fine needle aspiration determining the diagnosis and best therapeutic options for the patients. ..
  8. Natural Killer Dendritic Cells in Listeria Infection
    Ronald DeMatteo; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  9. Gene Ratio Based Prognosis in Mesothelioma
    Raphael Bueno; Fiscal Year: 2007
    ..We will determine the accuracy of this test in predicting outcome as defined by survival and tumor progression. ..