splenic neoplasms

Summary

Summary: Tumors or cancer of the SPLEEN.

Top Publications

  1. ncbi Splenic metastases: clinicopathologic presentation, differential diagnosis, and pathogenesis
    Eva Comperat
    Service d Anatomie Pathologique, Hopital Pitie Salpetriere, Boulevard de l Hopital, 75013 Paris, France
    Arch Pathol Lab Med 131:965-9. 2007
  2. ncbi Alteration of BIRC3 and multiple other NF-κB pathway genes in splenic marginal zone lymphoma
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Blood 118:4930-4. 2011
  3. ncbi MR imaging of the spleen: spectrum of abnormalities
    Khaled M Elsayes
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Radiographics 25:967-82. 2005
  4. ncbi Splenic angiosarcoma: a clinicopathologic and immunophenotypic study of 28 cases
    T S Neuhauser
    Department of Hematopathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Mod Pathol 13:978-87. 2000
  5. ncbi Splenic marginal zone lymphoma with VH1-02 gene rearrangement expresses poly- and self-reactive antibodies with similar reactivity
    Abdirashid A Warsame
    Department of Pathology, University Hospital of Oslo, Oslo, Norway
    Blood 118:3331-9. 2011
  6. ncbi Deletion mapping on the long arm of chromosome 7 in splenic lymphoma with villous lymphocytes
    Alicja M Gruszka-Westwood
    Academic Department of Haematology and Cytogenetics, Institute of Cancer Research Royal Marsden NHS Trust, London, United Kingdom
    Genes Chromosomes Cancer 36:57-69. 2003
  7. ncbi Splenic marginal zone lymphomas are characterized by loss of interstitial regions of chromosome 7q, 7q31.32 and 7q36.2 that include the protection of telomere 1 (POT1) and sonic hedgehog (SHH) genes
    Francisco Vega
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Br J Haematol 142:216-26. 2008
  8. ncbi Hepatosplenic T-cell lymphoma in adolescents and young adults with Crohn's disease: a cautionary tale?
    Joel R Rosh
    Goryeb Children s Hospital Atlantic Health, Morristown, New Jersey, USA
    Inflamm Bowel Dis 13:1024-30. 2007
  9. ncbi Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome
    Andrea Rinaldi
    Laboratory of Experimental Oncology and Lymphoma Unit, Oncology Institute of Southern Switzerland, Via Vincenzo Vela 6, Bellinzona, Switzerland
    Blood 117:1595-604. 2011
  10. ncbi Analysis of the IgV(H) somatic mutations in splenic marginal zone lymphoma defines a group of unmutated cases with frequent 7q deletion and adverse clinical course
    Patricia Algara
    Department of Genetics and Pathology, Virgen de la Salud Hospital, Toledo, Spain
    Blood 99:1299-304. 2002

Research Grants

  1. ALVEOLAR TYPE II CELL GROWTH IN INJURY
    RANDOLPH HASTINGS; Fiscal Year: 2003
  2. Epidemiology of Marginal Zone Lymphoma
    Lisa Herrinton; Fiscal Year: 2003

Detail Information

Publications226 found, 100 shown here

  1. ncbi Splenic metastases: clinicopathologic presentation, differential diagnosis, and pathogenesis
    Eva Comperat
    Service d Anatomie Pathologique, Hopital Pitie Salpetriere, Boulevard de l Hopital, 75013 Paris, France
    Arch Pathol Lab Med 131:965-9. 2007
    ..Splenic metastases occur in a context of multivisceral disseminated cancer or as a solitary lesion...
  2. ncbi Alteration of BIRC3 and multiple other NF-κB pathway genes in splenic marginal zone lymphoma
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Blood 118:4930-4. 2011
    ..Genetic lesions of NF-κB provide a molecular basis for the pathogenesis of more than 30% of SMZLs and offer a suitable target for NF-κB therapeutic approaches in this lymphoma...
  3. ncbi MR imaging of the spleen: spectrum of abnormalities
    Khaled M Elsayes
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Radiographics 25:967-82. 2005
    ..MR imaging is an excellent tool for diagnosis and evaluation of focal lesions and pathologic conditions of the spleen...
  4. ncbi Splenic angiosarcoma: a clinicopathologic and immunophenotypic study of 28 cases
    T S Neuhauser
    Department of Hematopathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Mod Pathol 13:978-87. 2000
    ..The majority of splenic angiosarcomas coexpress histiocytic and endothelial markers by immunohistochemical analysis, which suggest that some tumors may originate from splenic lining cells...
  5. ncbi Splenic marginal zone lymphoma with VH1-02 gene rearrangement expresses poly- and self-reactive antibodies with similar reactivity
    Abdirashid A Warsame
    Department of Pathology, University Hospital of Oslo, Oslo, Norway
    Blood 118:3331-9. 2011
    ..The results indicate that a common subset of SMZL arises from polyreactive B cells, a subset of marginal zone B cells that are important in the immunologic defense against infection...
  6. ncbi Deletion mapping on the long arm of chromosome 7 in splenic lymphoma with villous lymphocytes
    Alicja M Gruszka-Westwood
    Academic Department of Haematology and Cytogenetics, Institute of Cancer Research Royal Marsden NHS Trust, London, United Kingdom
    Genes Chromosomes Cancer 36:57-69. 2003
    ..The presence of a high incidence of abnormalities in the established hotspot areas and in particular the finding of biallelic deletions is indicative of the existence of genes important for the pathogenesis of SLVL in these areas...
  7. ncbi Splenic marginal zone lymphomas are characterized by loss of interstitial regions of chromosome 7q, 7q31.32 and 7q36.2 that include the protection of telomere 1 (POT1) and sonic hedgehog (SHH) genes
    Francisco Vega
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Br J Haematol 142:216-26. 2008
    ..In conclusion, SMZL, but not NMZL, demonstrates large genomic imbalances and frequent loss of the 7q31.32 and 7q36.2 regions involving POT1 and SHH, respectively. In NMZL, loss of FADD and gain of GLI1 are frequent events...
  8. ncbi Hepatosplenic T-cell lymphoma in adolescents and young adults with Crohn's disease: a cautionary tale?
    Joel R Rosh
    Goryeb Children s Hospital Atlantic Health, Morristown, New Jersey, USA
    Inflamm Bowel Dis 13:1024-30. 2007
    ..Additionally, a description of HSTCL and a summary of the known cases of this apparent therapeutic complication are presented. Clinical options in light of this new information are explored...
  9. ncbi Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome
    Andrea Rinaldi
    Laboratory of Experimental Oncology and Lymphoma Unit, Oncology Institute of Southern Switzerland, Via Vincenzo Vela 6, Bellinzona, Switzerland
    Blood 117:1595-604. 2011
    ..Although del(17p) did not determine a worse outcome and del(8p) was only of borderline significance, the presence of both deletions had a highly significant negative impact on the outcome of splenic MZLs...
  10. ncbi Analysis of the IgV(H) somatic mutations in splenic marginal zone lymphoma defines a group of unmutated cases with frequent 7q deletion and adverse clinical course
    Patricia Algara
    Department of Genetics and Pathology, Virgen de la Salud Hospital, Toledo, Spain
    Blood 99:1299-304. 2002
    ....
  11. ncbi A systematic review of factors that contribute to hepatosplenic T-cell lymphoma in patients with inflammatory bowel disease
    David S Kotlyar
    Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Clin Gastroenterol Hepatol 9:36-41.e1. 2011
    ..We investigated the medications, duration of therapy, and ages of patients associated with HSTCL...
  12. ncbi Angiosarcoma of the spleen clinically presenting as metastatic ovarian cancer. A case report and review of the literature
    Jose R Valbuena
    Department of Pathology and Laboratory Medicine, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4095, USA
    Ann Diagn Pathol 9:289-92. 2005
    ..However, histopathologic examination of the specimen showed the tumor to be of a primary angiosarcoma. We believe that the lengthy exposure to radiation may have played a role in the histopathogenesis of this neoplasm in this patient...
  13. ncbi Ultrasound-guided fine needle biopsy of the spleen: high clinical efficacy and low risk in a multicenter Italian study
    G Civardi
    Divisione di Medicina Interna Ematologia, Ospedale Civile, Piacenza, Italy
    Am J Hematol 67:93-9. 2001
    ..Aspiration cytology and core needle biopsy showed similar diagnostic yields, except for the diagnosis of splenic lymphoma, in which core needle biopsy obtained better results...
  14. ncbi Canine hemangiosarcoma treated with standard chemotherapy and minocycline
    K Sorenmo
    Department of Clinical Studies and Pathobiology, Veterinary Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    J Vet Intern Med 14:395-8. 2000
    ..Postmortem examination revealed widespread metastasis, suggesting that minocycline is ineffective as a single antiangiogenic agent in canine hemangiosarcoma...
  15. ncbi Littoral cell angiosarcoma: a truly malignant tumor
    Renato Rosso
    Am J Surg Pathol 28:1255. 2004
  16. ncbi [Rupture of the spleen in angiosarcoma: a case report and review of the literature]
    Roberto Sivelli
    Clinica Chirurgica Generale e dei Trapianti d Organo Università degli Studi di Parma
    Chir Ital 57:377-80. 2005
    ..It is important to perform a splenectomy before splenic rupture owing to its negative impact on long-term survival...
  17. pmc BCR and TLR signaling pathways are recurrently targeted by genetic changes in splenic marginal zone lymphomas
    Qingguo Yan
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, UK
    Haematologica 97:595-8. 2012
    ..These results strongly suggest that deregulation of the TLR (toll like receptor) and BCR (B-cell receptor) signaling pathway may play an important role in the pathogenesis of splenic marginal zone lymphoma...
  18. ncbi Giant splenic metastasis due to lung adenocarcinoma
    Ana Sánchez-Romero
    Servicio de Cirugia General y del Aparato Digestivo, Hospital General Universitario de Elche, Elche, Alicante, Spain
    Clin Transl Oncol 8:294-5. 2006
    ..The patient underwent splenectomy, which confirmed the diagnose of splenic metastasis of lung adenocarcinoma and, secondly, lung resection was performed. Topics about lung cancer metastasis are discussed...
  19. ncbi Hepatosplenic alphabeta T cell lymphoma
    Yuya Nagai
    Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital, 4 6 Minatojima Nakamachi, Chuo Ku, Kobe 650 0046, Japan
    Int J Clin Oncol 15:215-9. 2010
    ..Since hepatosplenic alphabeta T cell lymphoma is very rare with only 23 reported cases to date, herein we report this case and discuss the therapeutic strategy...
  20. pmc Molecular characterization of the region 7q22.1 in splenic marginal zone lymphomas
    Cristina Robledo
    Unidad de Diagnóstico Molecular y Celular del Cáncer, IBMCC, Centro de Investigacion del Cancer, Universidad de Salamanca CSIC, Salamanca, Spain
    PLoS ONE 6:e24939. 2011
    ..A loss of 7q22.1 at 99925039-101348479 bp was observed in half of the cases. The region of 7q22.1 has not previously been characterised in SMZL. Our results confirmed the presence of a new region of loss on chromosome 7 in these NHL...
  21. ncbi [Splenic metastasis of lung cancer]
    Katsutoshi Ando
    Department of Pulmonology, Kameda Medical Center
    Nihon Kokyuki Gakkai Zasshi 47:581-4. 2009
    ..Therefore, we considered that splenectomy could possibly improve the prognosis of this patient with isolated splenic metastasis. We report a case with a brief review of the literature and summarize the 13 reported cases...
  22. ncbi [Solitary splenic metastases from lung cancer--one-time surgical procedure]
    Dariusz Tomaszewski
    Z Katedry i Kliniki Chirurgii Klatki Piersiowej AM w Gdańsku
    Pneumonol Alergol Pol 71:533-7. 2003
    ..Upper left lobectomy and splenectomy were done by the left postero-lateral thoracotomy with phrenotomy. The rarity of solitary spleen metastasis from lung cancer and the treatment are discussed...
  23. ncbi Hepatosplenic T-cell lymphoma following infliximab therapy for Crohn's disease
    Musa Drini
    Department of Colorectal Medicine and Genetics, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    Med J Aust 189:464-5. 2008
    ..We describe the first case in Australia of hepatosplenic T-cell lymphoma in a patient who had been treated with infliximab and immunomodulators for Crohn's disease...
  24. ncbi [Angiosarcoma as a rare differential diagnosis in spontaneous rupture of the spleen]
    A Maier
    Klinik und Poliklinik für Chirurgie, Universitat Regensburg
    Chirurg 75:70-4. 2004
    ..Due to the small number of reported cases, there are no guidelines for adjuvant or palliative therapy, and up to today all adjuvant means of radiotherapy and chemotherapy have not improved the prognosis of the patients...
  25. ncbi Spleen rupture due to primary angiosarcoma: a case report
    Ioannis M Koutelidakis
    2nd Department of Surgery, Aristoteles University of Thessaloniki, G Gennimatas General Hospital, Thessaloniki, Greece
    J Gastrointest Cancer 38:74-7. 2007
    ..Splenectomy prior to rupture seems to have a positive impact on long-term survival...
  26. ncbi Hepatosplenic T-cell lymphoma and inflammatory bowel disease
    Anne Thai
    University of California, Davis Medical Center UCDMC, Internal Medicine, 4150 V Street, Suite 3100, Sacramento, CA 95817, United States
    J Crohns Colitis 4:511-22. 2010
    ..In addition, we explore the history of reported cases of hepatosplenic T-cell lymphoma in relation to the possible existence of a causal relationship between infliximab use and HSTCL. The treatments for HSTCL will be briefly addressed...
  27. ncbi Isolated splenic metastasis from lung cancer: ringleader of continuous fever
    H Tang
    Dept of Respiratory Medicine, Changzheng Hospital, Second Military Medical University, Shanghai, China
    Eur Respir Rev 19:253-6. 2010
    ..We also reviewed all 11 reported previously cases and summarised the characteristics and appropriate management of isolated splenic metastasis from lung cancer...
  28. ncbi Splenic marginal zone B-cell lymphoma: a distinct clinicopathological and molecular entity. Recent advances in ontogeny and classification
    A Traverse-Glehen
    Hospices Civils de Lyon, Service d Anatomie Pathologique, Centre Hospitalier Lyon Sud, Pierre Benite, Universite Lyon 1, UMR CNRS 5239 Equipe Pathologie des Cellules Lymphoides, Lyon, France
    Curr Opin Oncol 23:441-8. 2011
    ....
  29. ncbi Hepatosplenic alphabeta T-cell lymphomas: a report of 14 cases and comparison with hepatosplenic gammadelta T-cell lymphomas
    W R Macon
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Surg Pathol 25:285-96. 2001
    ..This group, along with the previously recognized gammadelta group, should be recognized as phenotypically heterogeneous subtypes of the same disease entity...
  30. ncbi [Spontaneous spleen rupture due to primary splenic angiosarcoma: a case report]
    Burhan Mayir
    Department of General Surgery, Medicine Faculty of Akdeniz University, Antalya, Turkey
    Ulus Travma Acil Cerrahi Derg 13:313-5. 2007
    ..Spleen angiosarcoma must be considered in the differential diagnosis of patients with unexplained anemia, splenic mass and splenomegaly. It has rapid course and poor prognosis. Splenectomy must be performed because of threat of rupture...
  31. ncbi Assessment of the frequency of additional cancers in patients with splenic marginal zone lymphoma
    Emilio Iannitto
    Hematology and BMT Unit, Department of Oncology, University of Palermo, Palermo, Italy
    Eur J Haematol 76:134-40. 2006
    ..The purpose of the present study was to estimate the standardised incidence ratio (SIR) and the absolute excess risk (AER) of SPC in patients with splenic marginal zone lymphoma (SMZL)...
  32. doi Long-term survival in two patients with hepatosplenic T cell lymphoma treated with interferon-alpha
    Michael Robert Humphreys
    Leuk Lymphoma 49:1420-3. 2008
  33. pmc Splenic diffuse red pulp small B-cell lymphoma: revision of a series of cases reveals characteristic clinico-pathological features
    George Kanellis
    Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Haematologica 95:1122-9. 2010
    ..Additional work is required to review this entity and establish its diagnostic features...
  34. ncbi Splenic marginal zone lymphoma: clinical characteristics and prognostic factors in a series of 60 patients
    Jose I Chacón
    Medical Oncology Service, Pathologic Anatomy Department, Hospital Virgen de la Salud, Toledo, Spain
    Blood 100:1648-54. 2002
    ..These data confirm the relative indolence of this disease, indicating the existence of a subset of more aggressive cases, which should stimulate the search for predictive biologic factors and alternative therapies...
  35. ncbi Primary histiocytic sarcoma of the spleen associated with erythrophagocytic histiocytosis
    Josee Audouin
    Service central Jacques Delarue d Anatomie et de Cytologie Pathologiques, Hotel Dieu, Paris, France
    Pathol Res Pract 199:107-12. 2003
    ..The association with a reactive histiocytosis with erythrophagocytosis corresponds to "histiocytic medullary reticulosis", as previously described by Scott and Robb-Smith...
  36. ncbi Graft-versus-lymphoma effect in progressive hepatosplenic gamma/delta T-cell lymphoma
    Simon He
    Leuk Lymphoma 48:1448-50. 2007
  37. ncbi Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis
    Elena Ruiz-Ballesteros
    Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas, C Melchor Fernandez Almagro 3, E 28 029 Madrid, Spain
    Blood 106:1831-8. 2005
    ..Shorter survival was associated with CD38 expression, naive IgV(H) genes, and the expression of a set of NF-kappaB pathway genes, including TRAF5, REL, and PKCA...
  38. ncbi Isolated splenic metastasis from primary lung adenocarcinoma
    Brian J Schmidt
    Department of General Surgery, Mayo Clinic Jacksonville, Jacksonville, FL, USA
    South Med J 97:298-300. 2004
    ..We report a rare case of an asymptomatic, isolated splenic metastasis in a 72-year-old man diagnosed 25 months after resection of an adenocarcinoma of the lung...
  39. ncbi Splenic marginal zone lymphoma proposals for a revision of diagnostic, staging and therapeutic criteria
    E Matutes
    Section of Haemato oncology, Institute of Cancer Research, London, UK
    Leukemia 22:487-95. 2008
    ....
  40. ncbi Splenic marginal zone B-cell lymphomas: two cytogenetic subtypes, one with gain of 3q and the other with loss of 7q
    F Sole
    Laboratori de Citologia Hematologica, Laboratori de Referència de Catalunya, Departament de Patologia, Hospital del Mar, IMAS, IMIM, Passeig Maritim, 25 29, 08003 Barcelona, Spain
    Haematologica 86:71-7. 2001
    ..In the present study we performed conventional cytogenetics and in situ hybridization studies in 47 patients with SMZBCL...
  41. ncbi Splenic metastases in a large unselected autopsy series
    Corinna Ariane Schön
    Institute of Pathology, Philipps University Marburg, Baldingerstrasse, Marburg 35033, Germany
    Pathol Res Pract 202:351-6. 2006
    ..The present study underlines the importance of spleen metastasis as an indicator of poor prognosis. There are, however, various aspects as to the detection and morphology of spleen metastasism, which merit further scrutiny...
  42. ncbi MicroRNA losses in the frequently deleted region of 7q in SMZL
    E Ruiz-Ballesteros
    Leukemia 21:2547-9. 2007
  43. ncbi Splenic marginal zone lymphoma
    Vito Franco
    Istituto di Anatomia e Istologia Patologica and Divisione di Ematologia con TMO, University of Palermo, Palermo, Italy
    Blood 101:2464-72. 2003
    ..To date, no definitive therapy has been established. Therapeutic options include treatment abstention, splenectomy, splenic irradiation, and chemotherapy...
  44. ncbi Solitary splenic lesions
    David M Warshauer
    Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7510, USA
    Semin Ultrasound CT MR 27:370-88. 2006
    ..Percutaneous biopsy may be used for histologic diagnosis when required...
  45. ncbi Recurrent genomic imbalances in B-cell splenic marginal-zone lymphoma revealed by comparative genomic hybridization
    Claus L Andersen
    Department of Hematology, Laboratory of Cancer Cytogenetics, Arhus Sygehus, Tage Hansens Gade 2, DK 8000 Arhus C, Denmark
    Cancer Genet Cytogenet 156:122-8. 2005
    ..Our data suggest that SMZL constitute a genetically heterogeneous disease where gain of 3q25 and loss of 7q31 are the most likely imbalances to be involved in the pathogenesis of the disease...
  46. ncbi Hepatosplenic T-cell lymphoma in a patient with Crohn's disease who received infliximab therapy
    Amer Zeidan
    Leuk Lymphoma 48:1410-3. 2007
  47. ncbi [Spontaneous splenic rupture due to splenic metastasis of lung cancer]
    F Lachachi
    Service de chirurgie viscérale et transplantation, Hopital Universitaire Dupuytren, 2 Avenue Martin Luther King, 87042 Limoges Cedex, France
    Ann Chir 129:521-2. 2004
    ..Chest X-ray revealed a right lung superior lobe tumor, related to poorly differentiated carcinoma. Total splenectomy is a good option for diagnosis and treatment of splenic metastases...
  48. ncbi Multiple lesions of the spleen: differential diagnosis of cystic and solid lesions
    Aya Kamaya
    Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Semin Ultrasound CT MR 27:389-403. 2006
    ..Radiologists should be aware of the spectrum of processes that may involve the spleen and the clinical context in which they occur...
  49. ncbi Isolated splenic metastasis from non small cell lung cancer
    C S Pramesh
    Division of Thoracic Surgery, Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, India
    Ann Thorac Cardiovasc Surg 10:247-8. 2004
    ..We report a middle-aged man who presented to us with locoregionally advanced non small cell lung cancer, progressed on neoadjuvant chemotherapy and developed isolated splenic metastasis...
  50. ncbi Splenic marginal zone lymphomas presenting with splenomegaly and typical immunophenotype are characterized by allelic loss in 7q31-32
    Ronald Boonstra
    Departments of Pathology and Laboratory Medicine, University Medical Center Groningen, The Netherlands
    Mod Pathol 16:1210-7. 2003
    ..The findings indicate that SMZL with primary splenic presentation and the typical IgM+, IgDdim, CD5-, CD10-, CD23- immunophenotype is characterized by the presence of deletions in chromosome 7q31-32...
  51. ncbi Solitary splenic metastasis derived from esophageal cancer
    Yasue Kimura
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Hepatogastroenterology 50:1336-7. 2003
    ..Transarterial embolization of the splenic artery was without effect. A splenectomy was then done and histological examination of the resected specimen revealed squamous cell carcinoma derived from the esophageal carcinoma...
  52. ncbi Solitary splenic metastasis of an adenocarcinoma of the lung 2 years postoperatively
    I Van Hul
    Department of General Surgery, Sint Vincentiusziekenhuis, Antwerp, Belgium
    Acta Chir Belg 108:462-3. 2008
    ..Most patients with splenic metastases have widely disseminated metastatic disease. We report a case of an asymptomatic, isolated splenic metastasis in a 67-year-old man diagnosed 2 years after resection of an adenocarcinoma of the lung...
  53. ncbi Hepatosplenic T-cell lymphoma in a patient with Crohn's disease
    Florian Beigel
    Department of Medicine II, University Hospital, Munich Grosshadern, Munich, Germany
    Nat Rev Gastroenterol Hepatol 6:433-6. 2009
    ..He had been taking azathioprine therapy for approximately 5.5 years and had received high-dose steroids. He had also previously taken metronidazole and antihypertensive medications...
  54. ncbi Over 30% of patients with splenic marginal zone lymphoma express the same immunoglobulin heavy variable gene: ontogenetic implications
    V Bikos
    Democritus University of Thrace, Alexandroupolis, Greece
    Leukemia 26:1638-46. 2012
    ..Furthermore, they raise the possibility that certain SMZL subtypes could derive from progenitor populations adapted to particular antigenic challenges through selection of VH domain specificities, in particular the IGHV1-2(*)04 allele...
  55. ncbi Splenic marginal zone lymphoma: characterization of 7q deletion and its value in diagnosis
    A James Watkins
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, UK
    J Pathol 220:461-74. 2010
    ..In conclusion, 7q32 deletion is a characteristic feature of SMZL, albeit seen in isolated cases of splenic B-cell lymphoma/leukaemia unclassifiable, and its detection may help the differential diagnosis of splenic B-cell lymphomas...
  56. ncbi Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection
    Olivier Hermine
    Department of Hematology and Centre National de la Recherche Scientifique Unité Mixte de Recherche 8603, Hopital Necker, Paris, France
    N Engl J Med 347:89-94. 2002
    ..We undertook this study after a patient with splenic lymphoma with villous lymphocytes had a hematologic response after antiviral treatment of HCV infection...
  57. ncbi Littoral cell angioma in main and accessory intrapancreatic spleen presenting as splenic rupture
    Julia B Pilz
    Department of Gastroenterology, Liestal Hospital, Switzerland
    Am J Surg 201:e15-7. 2011
    ..To our knowledge, this is the first description of littoral cell angioma of the spleen involving both main and accessory organ presenting as splenic rupture...
  58. ncbi Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B-cell lymphomas: a multicenter study of the Splenic B-Cell Lymphoma Group
    Marta Salido
    Hospital del Mar, IMAS, Barcelona, Spain
    Blood 116:1479-88. 2010
    ..Complexity of the karyotype, 14q aberrations, and TP53 deletions are poor prognostic indicators and may be considered together with other clinicobiologic parameters to ascertain the prognosis of SMZL...
  59. ncbi p53 abnormalities in splenic lymphoma with villous lymphocytes
    A M Gruszka-Westwood
    Academic Department of Haematology and Cytogenetics, Institute of Cancer Research/Royal Marsden NHS Trust, Fulham Rd, London, SW3 6JJ United Kingdom
    Blood 97:3552-8. 2001
    ..Although p53 abnormalities are infrequent in SLVL, they underlie a more aggressive disease course and poor prognosis. (Blood. 2001;97:3552-3558)..
  60. ncbi [Littoral-cell angioma--a rare differential diagnosis on splenic tumors]
    J Sauer
    Klinik und Poliklinik fur Allgemein und Abdominalchirurgie, Johannes Gutenberg Universitat Mainz
    Dtsch Med Wochenschr 124:624-8. 1999
    ..HISTORY AND PRE-ADMISSION FINDINGS: Routine abdominal sonography of a 51-year-old man 6 years after removal of the right testis and radiotherapy for a seminoma revealed a 3 cm mass within the spleen...
  61. pmc Incidental littoral cell angioma of the spleen
    May Tee
    Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    World J Surg Oncol 6:87. 2008
    ..Littoral cell angioma (LCA) is a recently described primary vascular neoplasm of the spleen that may be associated with other malignancies and may itself also have malignant potential...
  62. ncbi Histiocytic sarcoma of the spleen: case report of asymptomatic onset of thrombocytopenia and complex imaging features
    Shinichi Kobayashi
    Division of Hematology, Department of Internal Medicine, National Defense Medical College, Tokorozawa, Saitama 359 8513, Japan
    Int J Hematol 87:83-7. 2008
    ..Histiocytic sarcoma of the spleen should be considered as a differential diagnosis in therapeutically unresponsive patients with chronic thrombocytopenia...
  63. ncbi Primary histiocytic sarcoma of the spleen associated with hemophagocytosis
    Koji Oka
    Department of Internal Medicine, Suzuka Kaisei Hospital, 112 1 Koh chou, Suzuka, Mie 513 0836, Japan
    Int J Hematol 87:405-9. 2008
    ..CD163 expression by neoplastic cells could be confirmed only after careful observation, because the molecule may only be seen in some of the neoplastic cells...
  64. ncbi Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease
    Ann Corken Mackey
    Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, MD, USA
    J Pediatr Gastroenterol Nutr 44:265-7. 2007
    ..It has not been established that infliximab had an exclusive or primary role in the pathogenesis of these HSTCL cases; however, it appears that patients using this product may be at greater risk for developing this rare lymphoma...
  65. ncbi [Littoral cell angioma of the spleen. Association with colon and hepatocellular carcinoma]
    T Hansen
    Institut fur Pathologie, Universitätsmedizin Mainz, Langenbeckstr 1, 55101, Mainz, Deutschland
    Pathologe 31:290-2. 2010
    ..In addition a hepatocellular carcinoma was found. Due to the relationship with malignant tumors littoral cell angioma should be considered in every case of a splenic tumoral space-occupying mass, particularly in carcinoma patients...
  66. ncbi Splenic marginal zone lymphoma: a prognostic model for clinical use
    Luca Arcaini
    Division of Hematology, IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy
    Blood 107:4643-9. 2006
    ..In conclusion, with the use of readily available factors, this prognostic index may be an effective tool for evaluating the need for treatment and the intensity of therapy in an individual patient...
  67. pmc Novel genomic imbalances in B-cell splenic marginal zone lymphomas revealed by comparative genomic hybridization and cytogenetics
    J M Hernandez
    Servicio de Hematologia, Hospital Universitario and Centro de Investigación del Cáncer, Universidad de Salamanca CSIC, Salamanca, Spain
    Am J Pathol 158:1843-50. 2001
    ..05). In summary, chromosomal imbalances in regions 3q, 4q, 5q, 7q, 9q, 12q, and 20q have been detected by CGH in SMZL. Patients with SMZL displaying genetic losses by CGH had a short survival...
  68. ncbi Hepatosplenic T-cell lymphoma in a young man with Crohn's disease: case report and literature review
    Mark G Ochenrider
    Division of Internal Medicine, Virginia Mason Medical Center, Seattle, WA 98101, USA
    Clin Lymphoma Myeloma Leuk 10:144-8. 2010
    ..Additional research is needed to better understand the role of thiopurines and TNF-alpha inhibitors in promoting HSTCL and what can be done to prevent and treat this devastating malignancy in young patients with Crohn's disease...
  69. pmc Littoral cell angioma (LCA) associated with liver cirrhosis
    Hi Gu Kim
    Department of Internal Medicine, Gastroenterology Division, Inha University Hospital, Inha University, 7 206, 3 Ga, Shinheung Dong, Jung Gu, Incheon 400 103, Korea
    Yonsei Med J 46:184-8. 2005
    ..There has been no previous report of a LCA combined with liver cirrhosis. Herein, the first case of a LCA in Korea, diagnosed and treated by a splenectomy, is reported...
  70. ncbi Hepatosplenic T-gammadelta lymphoma in a patient with Crohn's disease treated with azathioprine
    José Tomás Navarro
    Department of Haematology, Hospital Universitari Germans Trias i Pujol, Badalona, Universitat Autonoma de Barcelona, Barcelona, Spain
    Leuk Lymphoma 44:531-3. 2003
    ..The patient did not respond to intensive chemotherapy. This case shows the importance of ruling out HSgammadeltaTCL in patients with hepatosplenomegaly, B-symptoms and any immunosuppressive condition...
  71. ncbi Sclerosing angiomatoid nodular transformation (SANT): report of 25 cases of a distinctive benign splenic lesion
    Maritza Martel
    Department of Pathology, The National Cancer Institute, Milan, Italy
    Am J Surg Pathol 28:1268-79. 2004
    ....
  72. ncbi Presentation of esophageal cancer with solitary splenic metastasis
    Luigi Cavanna
    Am J Clin Oncol 28:636-7. 2005
  73. ncbi Splenic metastasis from esophageal cancer: report of a case
    Sudip Sanyal
    Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Surg Today 35:988-90. 2005
    ..A splenectomy, distal pancreatectomy, and resection of the splenic flexure with colocolic anastomosis were performed. A histological examination of the resected specimen showed squamous cell carcinoma...
  74. ncbi Late splenic metastasis after curative resection for oesophageal carcinoma
    Soumil J Vyas
    Department of Thoracic Surgery, Tata Memorial Hospital, Bombay, India
    Eur J Cardiothorac Surg 22:1011-3. 2002
    ..We report herewith one such instance of metastatic involvement of the spleen in an operated case of carcinoma oesophagus...
  75. ncbi Image of the month. Littoral cell angioma
    Shih Ping Cheng
    Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan
    Arch Surg 140:1127-8. 2005
  76. ncbi Primary angiosarcoma of the spleen in a child with long-term survival
    Jun Te Hsu
    Department of Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    Pediatr Surg Int 23:807-10. 2007
    ..The postoperative course was uneventful. The patient was disease free at 16 years after surgery. This is the longest reported duration of survival in a patient with splenic angiosarcoma...
  77. ncbi Antiangiogenic therapy for a large splenic hemangioma
    Saleem Islam
    Department of Surgery, Division of Pediatric Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Pediatr Surg Int 21:1007-10. 2005
    ..Antiangiogenic treatment has not been reported previously as an effective alternative for this type of lesion. We report our experience of successfully using glucocorticoids in an infant with a large hemangioma of the spleen...
  78. ncbi Splenic marginal zone lymphoma with micronodular T-cell rich B-cell lymphoma
    Sa A Wang
    Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Surg Pathol 30:128-32. 2006
    ..We describe a unique case of splenic marginal zone lymphoma associated with micronodular T cell/histiocyte-rich large B-cell lymphoma in the red pulp, a combination that has not previously reported in the literature...
  79. ncbi Littoral cell angioma
    Craig Johnson
    Department of Diagnostic Radiology, Northeastern Ohio Universities College of Medicine Canton Affiliated Hospitals, 2600 Sixth Street SW, Canton, OH 44710, USA
    Clin Imaging 31:27-31. 2007
    ..LCA was diagnosed by ultrasound (US)-guided biopsy. She was successfully treated with laparoscopic splenectomy. The CT, MRI, US, and Tc99m-RBC scan characteristics are described along with histologic and immunohistochemical correlation...
  80. ncbi Littoral cell angioma of the spleen
    Shweta Bhatt
    Department of Radiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 648, Rochester, NY 14642, USA
    AJR Am J Roentgenol 188:1365-6. 2007
  81. ncbi Splenic micronodular T-cell/histiocyte-rich large B-cell lymphoma
    Elena Kan
    Departments of Pathology and Hematology, Soroka University Medical Center, PO Box 151, Beer Sheva 84101, Israel
    Ann Diagn Pathol 12:290-2. 2008
    ..Our case presents minor variations on the recorded features. Possible reasons for the scarcity of reports and for the confirmation of this lymphoma as a variant of T-cell-rich large B-cell lymphoma are discussed...
  82. ncbi Littoral-cell angioma as a rare cause of splenomegaly
    N Suvajdzic
    Institute of Haematology, Clinical Center of Serbia, Belgrade, Serbia, Serbia and Montenegro
    Clin Lab Haematol 28:317-20. 2006
    ..The diagnosis was made after elective splenectomy. The CT images, scintigraphy and histological specimens are presented, and differential diagnoses discussed...
  83. ncbi Multiple littoral cell angioma of the spleen: a case report and review of the literature
    Zhi Bo Qu
    Department of General Surgery, First Clinical College of Harbin Medical University, P R China
    Onkologie 30:256-8. 2007
    ..Littoral cell angioma (LCA) is a rare benign vascular tumor of the spleen with characteristic histomorphologic features. It is a unique splenic tumor which may present with abdominal pain or as an incidental finding...
  84. ncbi Metachronous splenic metastasis from colonic carcinoma five years after surgery: a case report and literature review
    Pierpaolo Sileri
    From the Departments of Surgery and Pathology, University of Rome Tor Vergata, Rome, Italy
    South Med J 102:733-5. 2009
    ..We also review the scant literature experience discussing clinical diagnosis and approaches to this uncommon event...
  85. ncbi Solitary metastatic ovarian carcinoma of the spleen: a case report
    Y Minagawa
    Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan
    Asia Oceania J Obstet Gynaecol 17:45-8. 1991
    ..In this paper we report a case of a solitary metastatic lesion of the spleen arising from a serous cystadenocarcinoma of the ovary 5 years after the initial operation. A splenectomy was performed followed by smooth postoperative course...
  86. ncbi Metastasizing splenic littoral cell hemangioendothelioma
    Susan Fernandez
    Department of Pathology, Stanford University, Stanford, CA 94305, USA
    Am J Surg Pathol 30:1036-40. 2006
    ..This case suggests that the presence of solid areas of clear cells in a littoral cell angioma may be a marker of low-grade malignant potential in these tumors...
  87. ncbi Littoral cell angioma: a case report and review
    Rhonda L Harmon
    GI Endocrine Surgery, Department of Surgery, University of Texas Southwestern, Dallas, Texas 75390 9156, USA
    Curr Surg 63:345-50. 2006
  88. ncbi Littoral cell angioma mimicking pancreatic tumor
    Hizir Akyildiz
    Department of General Surgery, Erciyes University School of Medicine, Kayseri, Turkey
    Surgery 141:690-1. 2007
  89. pmc Tumours of the spleen
    Andrea Giovagnoni
    Department of Radiology, University Politecnica delle Marche, Ancona, Italy
    Cancer Imaging 5:73-7. 2005
    ..The principal tumoral masses, benign (cysts, haemangiomas, litteral cell angioma, lymphangioma) and malignant (lymphoma, metastases haemangiosarcoma), are described...
  90. ncbi Combination of rituximab, cyclophosphamide, and vincristine induces complete hematologic remission of splenic marginal zone lymphoma
    Luca Arcaini
    Division of Hematology, IRCCS Policlinico San Matteo, University of Pavia, Italy
    Clin Lymphoma 4:250-2. 2004
    ..The immunochemotherapy regimen was well tolerated and all patients exhibited complete remission. To our knowledge, this is the first report of splenic MZL showing response to a combination of rituximab with chemotherapy...
  91. ncbi Does complete resection of melanoma metastatic to solid intra-abdominal organs improve survival?
    T F Wood
    John Wayne Cancer Institute, Santa Monica, California 90404, USA
    Ann Surg Oncol 8:658-62. 2001
    ..We hypothesized that patients with metastatic disease to intra-abdominal solid organs might also benefit from complete surgical resection...
  92. ncbi Splenic tumour: a clinicopathological study
    L W Chen
    Department of Internal Medicine, Division of Gastroenterology, Chang Gung Memorial Hospital, Keelung, Taiwan
    Int J Clin Pract 58:924-7. 2004
    ..Splenectomy is recommended only for patients with malignancies or complications such as intractable abdominal pain, coagulopathy or tumour rupture with an unstable haemodynamic state...
  93. ncbi Progression to large B-cell lymphoma in splenic marginal zone lymphoma: a description of a series of 12 cases
    F I Camacho
    Molecular Pathology Program, , Madrid, Spain
    Am J Surg Pathol 25:1268-76. 2001
    ..The frequency of the 7q deletion in this series was 3 of 7 (42%). 7q loss may play an alternative role in the inactivation of the p53 and p16INK4a pathway, thereby favoring tumoral progression...
  94. ncbi Micronodular T-cell/histiocyte-rich large B-cell lymphoma of the spleen: histology, immunophenotype, and differential diagnosis
    Ahmet Dogan
    Department of Histopathology, University College London, London, UK
    Am J Surg Pathol 27:903-11. 2003
    ..The main differential diagnoses include granulomatous inflammation, Hodgkin's lymphoma, follicular lymphoma, and peripheral T-cell lymphomas...
  95. ncbi Splenic littoral cell haemangioendothelioma: a new low-grade variant of malignant littoral cell tumour
    O Ben-Izhak
    Department of Pathology, Rambam Medical Centre, Haifa, Israel
    Histopathology 39:469-75. 2001
    ..Littoral cell angioma is a recently described splenic vascular tumour of splenic sinus lining cells. Almost all cases of splenic littoral cell tumours hitherto described were benign...
  96. ncbi Pathologic quiz case: multiple splenic lesions in a bacteremic patient. Littoral cell angioma of the spleen
    Oluwole Fadare
    Department of Pathology, Yale University School of Medicine and Yale New Haven Hospital, New Haven, Conn 06504, USA
    Arch Pathol Lab Med 128:1183-5. 2004
  97. ncbi Splenic marginal-zone lymphoma: a distinct clinical and pathological entity
    Catherine Thieblemont
    Haematology Department, Centre Hospitalier Lyon Sud, Pierre, Benite, France
    Lancet Oncol 4:95-103. 2003
    ..Splenectomy is considered the first-line treatment of choice for splenic MZL; it results in only partial remission, but responses are generally sufficient for correcting cytopenia, improving quality of life, and increasing survival...
  98. ncbi From the archives of the AFIP: primary vascular neoplasms of the spleen: radiologic-pathologic correlation
    Robert M Abbott
    Radiographics 24:1137-63. 2004
    ..Splenectomy may be required for definitive evaluation of a splenic mass with atypical features...
  99. ncbi Test and teach. Incidentally discovered splenic vascular lesion. Littoral cell angioma of the spleen
    Nicholas J Musgrave
    Department of Anatomical Pathology and Cytopathology, Royal Brisbane Hospital, Brisbane, Queensland, Australia
    Pathology 34:579-81. 2002
  100. ncbi Littoral cell angioma of the spleen: appearance on sonography and CT
    Moshe Goldfeld
    Department of Radiology, Western Galilee Hospital, POB 21, Nahariya, Israel
    J Clin Ultrasound 30:510-3. 2002
    ..The patient's recovery was uneventful. LCA should be considered when making a differential diagnosis of splenic lesions, and sonography may be more helpful than CT in reaching a diagnosis of LCA...
  101. ncbi Littoral cell angioma of the spleen: CT features with clinicopathologic comparison
    Angela D Levy
    Departments of Radiologic Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Washington, DC 20306 6000, USA
    Radiology 230:485-90. 2004
    ..To evaluate the clinical, pathologic, and computed tomographic (CT) features of littoral cell angioma of the spleen in eight patients...

Research Grants2

  1. ALVEOLAR TYPE II CELL GROWTH IN INJURY
    RANDOLPH HASTINGS; Fiscal Year: 2003
    ..The project will evaluate the potential use of PTHrP-related therapeutic interventions that might speed or improve recovery following silica-induced lung injury. ..
  2. Epidemiology of Marginal Zone Lymphoma
    Lisa Herrinton; Fiscal Year: 2003
    ..abstract_text> ..