plasmacytoma

Summary

Summary: Any discrete, presumably solitary, mass of neoplastic plasma cells either in bone marrow or various extramedullary sites.

Top Publications

  1. pmc Plasmacytoma of bone, extramedullary plasmacytoma, and multiple myeloma: incidence and survival in the United States, 1992-2004
    Graca M Dores
    Department of Veterans Affairs Medical Center, Medical Service, Oklahoma City, OK 73104, USA
    Br J Haematol 144:86-94. 2009
  2. pmc Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1
    S Zhang
    Laboratory of Genetics, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Proc Natl Acad Sci U S A 95:2429-34. 1998
  3. ncbi An unusual presentation of extramedullary plasmacytoma occurring sequentially in the testis, subcutaneous tissue, and heart
    L A Fernandez
    Department of Medicine, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Nova Scotia, Canada
    Am J Hematol 67:194-6. 2001
  4. ncbi Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma
    R Burger
    Division of Hematology Oncology, Department of Medicine III, University of Erlangen Nuernberg, D 91054 Erlangen, Germany
    Hematol J 2:42-53. 2001
  5. ncbi Plasmacytoma relapses in the absence of systemic progression post-high-dose therapy for multiple myeloma
    Evangelos Terpos
    Department of Haematology, Faculty of Medicine Imperial College London, Hammersmith Hospital, London, UK
    Eur J Haematol 75:376-83. 2005
  6. ncbi Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors
    H Avet-Loiseau
    Hematology Laboratory, INSERM U463, and the Department of Clinical Hematology, University Hospital, Nantes, France
    Blood 98:3082-6. 2001
  7. ncbi Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice
    Sung Sup Park
    Laboratory of Genetics, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 65:1306-15. 2005
  8. ncbi Mouse plasmacytoma: an experimental model of human multiple myeloma
    K Gado
    National Institute of Hematology and Immunology, Budapest, Hungary
    Haematologica 86:227-36. 2001
  9. pmc Primary submucosal nodular plasmacytoma of the stomach: a poorly recognized variant of gastric lymphoma
    Maki Kanzawa
    Department of Diagnostic Pathology, Kobe University Hospital, Hyogo, Japan
    Diagn Pathol 8:30. 2013
  10. ncbi Expression of CD19 and lack of miR-223 distinguish extramedullary plasmacytoma from multiple myeloma
    Shan Chi Yu
    Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan
    Histopathology 58:896-905. 2011

Research Grants

  1. Lysophosphatidic Acid in Oncogenesis
    Xianjun Fang; Fiscal Year: 2010
  2. Defining genetic pathways of plasma-cell neoplasia
    Siegfried Janz; Fiscal Year: 2013
  3. INTERACTION OF AMINOTHIOLS AND ALKYLATING AGENTS
    Frederick Valeriote; Fiscal Year: 1990
  4. ANALYSIS OF IDIOTYPE MUTANTS
    Heinz Kohler; Fiscal Year: 1980
  5. SYNERGY OF TUMOR CHEMOTHERAPY AND HOST IMMUMITY
    SHELDON DRAY; Fiscal Year: 1991
  6. Chromatin Insulator Function at the C-myc Gene
    Anton Krumm; Fiscal Year: 2007
  7. PLASMACYTOMA RESISTANCE TO ALKYLATING AGENTS
    Carmelita Frondoza; Fiscal Year: 1993
  8. STROMAL CYTOKINE SIGNALING AND BIOLOGICAL FUNCTIONS
    Yu Chung Yang; Fiscal Year: 2001
  9. DEVELOPMENTAL CONTROL OF IMMUNOGLOBULIN TRANSCRIPTION
    Michael Atchison; Fiscal Year: 2005
  10. MECHANISM OF MELPHALAN-MEDIATED TUMOR ERADICATION
    MARGALIT MOKYR; Fiscal Year: 1990

Detail Information

Publications296 found, 100 shown here

  1. pmc Plasmacytoma of bone, extramedullary plasmacytoma, and multiple myeloma: incidence and survival in the United States, 1992-2004
    Graca M Dores
    Department of Veterans Affairs Medical Center, Medical Service, Oklahoma City, OK 73104, USA
    Br J Haematol 144:86-94. 2009
    Population-based plasmacytoma incidence and survival data are sparse...
  2. pmc Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1
    S Zhang
    Laboratory of Genetics, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Proc Natl Acad Sci U S A 95:2429-34. 1998
    ..assays with retinoblastoma protein, suggesting this defective, inherited allele plays an important role in the genetic susceptibility of BALB/c mice for plasmacytoma induction and that p16(INK4a) is a strong candidate for the Pctr1 locus.
  3. ncbi An unusual presentation of extramedullary plasmacytoma occurring sequentially in the testis, subcutaneous tissue, and heart
    L A Fernandez
    Department of Medicine, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Nova Scotia, Canada
    Am J Hematol 67:194-6. 2001
    Extramedullary plasmacytoma (EMP) is a rare neoplasm of soft tissue that usually arises in the respiratory tract, nasal cavity, sinuses, and nasopharynx. It is even more uncommon for it to arise either in the testis or heart...
  4. ncbi Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma
    R Burger
    Division of Hematology Oncology, Department of Medicine III, University of Erlangen Nuernberg, D 91054 Erlangen, Germany
    Hematol J 2:42-53. 2001
    ..Cytokines of the gp130-family, particularly interleukin(IL)-6, play a crucial role in the propagation of malignant plasma cells...
  5. ncbi Plasmacytoma relapses in the absence of systemic progression post-high-dose therapy for multiple myeloma
    Evangelos Terpos
    Department of Haematology, Faculty of Medicine Imperial College London, Hammersmith Hospital, London, UK
    Eur J Haematol 75:376-83. 2005
    ..The median time from SCT to plasmacytoma relapse was 24 months. The sites of plasmacytoma included bone, skin, rectum, and testicles...
  6. ncbi Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors
    H Avet-Loiseau
    Hematology Laboratory, INSERM U463, and the Department of Clinical Hematology, University Hospital, Nantes, France
    Blood 98:3082-6. 2001
    ....
  7. ncbi Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice
    Sung Sup Park
    Laboratory of Genetics, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 65:1306-15. 2005
    ..shift in Myc expression, a hallmark of MYC/Myc deregulation in human endemic Burkitt lymphoma and mouse plasmacytoma. Only 1 (6...
  8. ncbi Mouse plasmacytoma: an experimental model of human multiple myeloma
    K Gado
    National Institute of Hematology and Immunology, Budapest, Hungary
    Haematologica 86:227-36. 2001
    ..There is no ideal animal model for human multiple myeloma (MM). All the models resemble the human disease in some respect, but none of them fulfils all the criteria of a perfect animal model...
  9. pmc Primary submucosal nodular plasmacytoma of the stomach: a poorly recognized variant of gastric lymphoma
    Maki Kanzawa
    Department of Diagnostic Pathology, Kobe University Hospital, Hyogo, Japan
    Diagn Pathol 8:30. 2013
    Gastric plasmacytoma (GP) is a rare variant of gastric lymphomas. In the exceptional event that a patient presents with GP, the lesion occupies the mucosal layer in the vast majority of cases...
  10. ncbi Expression of CD19 and lack of miR-223 distinguish extramedullary plasmacytoma from multiple myeloma
    Shan Chi Yu
    Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan
    Histopathology 58:896-905. 2011
    Extramedullary plasmacytoma (EMP) and multiple myeloma (MM) are both plasma cell (PC) tumours that are usually distinguished by clinical manifestations, but not by histopathological examination alone...
  11. ncbi [Solitary plasmacytoma of spine: a clinical, radiologic and pathologic study of 13 cases]
    Miao Xia He
    Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Zhonghua Bing Li Xue Za Zhi 38:307-11. 2009
    To study the clinical, radiologic and pathologic features of solitary plasmacytoma of spine.
  12. ncbi TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications
    C S Mitsiades
    Jerome Lipper Multiple Myeloma Center, Department of Adult Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Blood 98:795-804. 2001
    ..These preclinical studies suggest that TRAIL/Apo2L can overcome conventional drug resistance and provide the basis for clinical trials of TRAIL-based treatment regimens to improve outcome in patients with MM. (Blood. 2001;98:795-804)..
  13. ncbi Testicular plasmacytoma: report of a case and review of the literature
    Gabriel Anghel
    Hematology and Bone Marrow Transplantation Unit, Azienda Ospedaliera S Camillo Forlanini, Rome, Italy
    Am J Hematol 71:98-104. 2002
    ..Fourteen months after the onset, the patient presented with left testicular enlargement due to plasmacytoma. Immunohistochemical stains showed monoclonal cytoplasmic IgA-lambda in tumour cells; serum M component showed ..
  14. pmc IL-6 transgenic mouse model for extraosseous plasmacytoma
    Alexander L Kovalchuk
    Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:1509-14. 2002
    ..comprise plasma cell myeloma, otherwise known as multiple myeloma, Ig deposition and heavy chain diseases, and plasmacytoma (PCT)...
  15. ncbi Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma
    Richard Soutar
    Clin Oncol (R Coll Radiol) 16:405-13. 2004
  16. pmc Extramedullary plasmacytoma of the head and neck region: clinicopathological correlation in 25 cases
    S S Susnerwala
    Department of Clinical Oncology, Christie Hospital, Manchester, UK
    Br J Cancer 75:921-7. 1997
    ..0019) but not for overall survival (P= 0.12). The median survival and 5-year overall survival is 68 months and 58.9% respectively. We recommend consideration of adjuvant chemotherapy in patients with higher grade disease...
  17. ncbi Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma
    Richard Soutar
    Department of Haematology, Western Infirmary, Glasgow, UK
    Br J Haematol 124:717-26. 2004
  18. ncbi Immunization against murine multiple myeloma with fusions of dendritic and plasmacytoma cells is potentiated by interleukin 12
    Jianlin Gong
    Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Blood 99:2512-7. 2002
    ..In this study, we have fused DCs with mouse 4TOO plasmacytoma cells...
  19. ncbi International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple Myeloma
    M Dimopoulos
    Department of Therapeutics, Alexandra Hospital, Athens, Greece
    Leukemia 23:1545-56. 2009
    ..recommended in MM patients with normal conventional radiography and in all patients with an apparently solitary plasmacytoma of bone...
  20. ncbi Solitary extramedullary plasmacytoma of the head and neck--long-term outcome analysis of 68 cases
    Gideon Bachar
    Department of Otolaryngology Head and Neck Surgery, Princess Margaret Hospital, Toronto, Canada
    Head Neck 30:1012-9. 2008
    ..Head and neck solitary extramedullary plasmacytomas are rare plasma cell neoplasms. Literature review reveals only small numbers of reports. The objective was to review our experience with treating patients with this neoplasm...
  21. ncbi Functional homology between N-myc and c-myc in murine plasmacytomagenesis: plasmacytoma development in N-myc transgenic mice
    Y Wang
    Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden
    Oncogene 7:1241-7. 1992
    ..All plasmacytomas expressed the N-myc transgene, while none of them expressed either c-myc or endogenous N-myc. None of the tumors carried the usual plasmacytoma-associated translocations.
  22. ncbi Rib plasmacytoma and IgA multiple myeloma with hyperviscosity syndrome
    Vitorino Modesto dos Santos
    Catholic University of Brasilia, DF, Brazil
    Arch Iran Med 15:517-9. 2012
    Solitary bone plasmacytoma (SPB) can progress to generalized myeloma if not treated early. The elderly population is increasing and delays in diagnosis of plasma cell malignancies are frequent among them...
  23. pmc Polyclonal rabbit anti-murine plasmacytoma cell globulins induce myeloma cells apoptosis and inhibit tumour growth in mice
    Bo Mu
    State Key Laboratory of Biotherapy, West China Hospital and School of Lifesciences, Sichuan University, Keyuan Road 4, Chengdu, Sichuan, People s Republic of China
    Apoptosis 16:370-81. 2011
    ..In this study, we produced polyclonal rabbit anti-murine plasmacytoma cell immunoglobulin (PAb) by immunizing rabbits with the murine plasmacytoma cell line MPC-11...
  24. pmc Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility
    S L Zhang
    Laboratory of Genetics, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 21:310-8. 2001
    ..that the BALB/c p16(INK4a) allele was less active than its DBA/2 counterpart in inducing growth arrest of mouse plasmacytoma cell lines and preventing ras-induced transformation of NIH 3T3 cells, while the two p19(ARF) alleles displayed ..
  25. ncbi The effect of chemical blockade of PKC with Gö6976 and Gö6983 on proliferation and MAPK activity in IL-6-dependent plasmacytoma cells
    Ianko Iankov
    Division of Immunology, Department of Microbiology, Preclinical University Center, Medical University, Zdrave 2 Street, 1431 Sofia, Bulgaria
    Leuk Res 26:363-8. 2002
    Interleukin-6 (IL-6) mediates growth of murine B9 hybridoma/plasmacytoma cells via Ras-dependent mitogen-activated protein kinase (MAPK) pathway...
  26. ncbi Plasmacytoma of the hard palate
    Ragip Ozdemir
    Ankara Training and Research Hospital, 1 Plastic and Reconstructive Surgery Clinic, Ankara, Turkey
    J Craniofac Surg 16:164-9. 2005
    ..This condition may occur as a solitary lesion (solitary plasmacytoma), which in some patients eventually progresses to plasma cell myeloma...
  27. ncbi Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics
    Karin Bink
    Institutes of Pathology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Oberschleissheim, Germany
    Haematologica 93:623-6. 2008
    Primary extramedullary plasmacytoma is an indolent neoplasm that infrequently converts to multiple myeloma...
  28. ncbi The impact of p53 loss on murine plasmacytoma development
    Sabine Mai
    Manitoba Institute of Cell Biology, The Genomic Centre for Cancer Research and Diagnosis, Department of Physiology, The University of Manitoba, Winnipeg, Canada
    Chromosome Res 10:239-51. 2002
    ..The 42.2% incidence in N3p53-/- mice is similar to the percentages recorded in groups of conventional BALB/cAn mice. The possible mechanisms underlying the accelerated tumorigenesis and the shift in translocation patterns are discussed...
  29. ncbi Surgical resection of a solitary plasmacytoma originating in a rib of a patient with Castleman's disease
    Simon Wilkinson
    Department of Thoracic Surgery, Bristol Royal Infirmary, Bristol, United Kingdom
    Ann Thorac Surg 75:1018-9. 2003
    ..a patient with Castleman's disease who presented with axillary lymphadenopathy associated with a solitary plasmacytoma originating from a rib...
  30. ncbi Exosomes from plasmacytoma cells as a tumor vaccine
    Stephen L Altieri
    Department of Immunology, Laboratory of Molecular Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Immunother 27:282-8. 2004
    ..The research presented here evaluated their efficacy as a prophylactic cancer vaccine in a mouse plasmacytoma model...
  31. ncbi Bcl-2 expression is associated with poor prognosis of solitary plasmacytoma of bone
    Shanqi Guo
    Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Huan Hu Xi Road, Ti Yuan Bei, He Xi District, Tianjin, 300060, People s Republic of China
    Ann Hematol 93:471-7. 2014
    Solitary plasmacytoma of bone (SPB) is a rare tumor that represents a minority of patients with plasma cell localized malignancy characterized by a single osteolytic bone lesion...
  32. pmc Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice
    Wan Cheung Cheung
    Cell Signaling Technology Inc, Beverly, Massachusetts, USA
    J Clin Invest 113:1763-73. 2004
    ..Our findings demonstrate that the enforced expression of Myc and Bcl-X(L) by Ig enhancers with peak activity in plasma cells generates a mouse model of human PCN that recapitulates some features of human multiple myeloma...
  33. ncbi Radiotherapy in the treatment of solitary plasmacytoma
    R Jyothirmayi
    Department of Radiotherapy, Regional Cancer Centre, Trivandrum, India
    Br J Radiol 70:511-6. 1997
    Solitary plasmacytoma of bone (SPB) and extramedullary plasmacytoma (EMP) are rare. High local control rates are reported with radiotherapy, although the optimal dose and extent of radiotherapy portals remains controversial...
  34. pmc Role of interleukin-6 in the pathogenesis of murine plasmacytoma and human multiple myeloma
    P K Pattengale
    Department of Pathology, Children s Hospital, Los Angeles, California 90027, USA
    Am J Pathol 151:647-9. 1997
  35. ncbi Allogeneic transplantation for multiple myeloma: late relapse may occur as localised lytic lesion/plasmacytoma despite ongoing molecular remission
    J L Byrne
    Department of Hematology, Nottingham City Hospital, Nottingham, UK
    Bone Marrow Transplant 31:157-61. 2003
    ..In five of these cases, relapse has been as a localised area of bone disease or isolated plasmacytoma with no evidence of marrow involvement by trephine biopsy or molecular analysis...
  36. ncbi Extramedullary plasmacytoma in the adrenal incidentaloma
    T Kahara
    First Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
    Clin Endocrinol (Oxf) 55:267-70. 2001
    ..The tumour was removed by laparoscopic adrenalectomy. The pathology specimen revealed the typical histology of plasmacytoma. Extramedullary plasmacytoma is a very rare type of plasma cell proliferative disorder...
  37. ncbi Clinical features and differential diagnoses of solitary extramedullary plasmacytoma of the thyroid: a case report
    Alfredo Avila
    Department of Pathology, Hospital Angeles del Carmen, Guadalajara 44670, Jalisco, Mexico
    Ann Diagn Pathol 13:119-23. 2009
    ..The tumor fulfilled the criteria of primary solitary extramedullary plasmacytoma (SEP), including cellular expression of the CD138 and lambda light chain antibodies...
  38. ncbi Sequential bilateral solitary extramedullary plasmacytoma of the ciliary body
    Carol L Shields
    Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cornea 26:759-61. 2007
    To report bilateral plasmacytoma of the ciliary body in a healthy patient.
  39. ncbi Extramedullary plasmacytoma: report of two cases with uncommon presentation
    D Pantelidou
    Hematology Department, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Ann Hematol 84:188-91. 2005
    ..forms of myeloma or may represent regional extension of extramedullary plasmacytomas, whereas lymph node plasmacytoma presenting as a solitary extramedullary plasmacytoma is very unusual...
  40. pmc Extramedullary plasmacytoma involving the bilateral adrenal glands on MR imaging
    Yuan Li
    Department of Radiology, West China Hospital, Sichuan University, Sichuan, China
    Korean J Radiol 8:246-8. 2007
    We report here on a 64-year-old woman with extramedullary plasmacytoma involving the bilateral adrenal glands...
  41. ncbi Extramedullary liver plasmacytoma a rare presentation
    Maria Teresa Petrucci
    Ematologia, Dipartimento di Biotecnologie Cellulari ed Ematologia, Universita La Sapienza, Roma, Italy
    Leuk Lymphoma 44:1075-6. 2003
    Liver plasmacytoma is a very rare form of solitary plasmacytoma, in fact the presence of plasma cells in the liver is generally associated with a more aggressive form of multiple myeloma...
  42. ncbi Blimp1 is limiting for transformation in a mouse plasmacytoma model
    Kathy D'Costa
    Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 113:5911-9. 2009
    ..Thus, the role of PRDM1/BLIMP1 in transformation of mature B cells is unclear. We have used a plasmacytoma-prone transgenic mouse model to study the effect of Blimp1 loss on plasmacytoma prevalence, latency, and ..
  43. ncbi Laryngeal plasmacytoma presenting as amyloid tumour: a case report
    D Velez
    Department of Pathology, La Princesa University Hospital, C Diego de Leon, 62, 28006, Madrid, Spain
    Eur Arch Otorhinolaryngol 264:959-61. 2007
    ..A biopsy showed histological findings consistent with an extramedullary plasmacytoma associated with localized amyloidosis involving the right hemilarynx (ventricular band, arytenoids and true ..
  44. ncbi A case of primary extramedullary plasmacytoma of the colon
    Arturo Lattuneddu
    Int J Colorectal Dis 19:289-91. 2004
  45. ncbi Primary gastric plasmacytoma refractory to Helicobacter pylori eradication therapy
    Naruo Kawasaki
    Department of Surgery, Jikei University School of Medicine, Tokyo, Japan
    Dig Endosc 21:37-9. 2009
    ..Immunohistochemically, plasma cells were positive for lambda-chain. Primary gastric plasmacytoma was diagnosed. Total gastrectomy was carried out with splenectomy and regional lymph node dissection...
  46. pmc Mndal, a new interferon-inducible family member, is highly polymorphic, suppresses cell growth, and may modify plasmacytoma susceptibility
    Ke Zhang
    Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4258, USA
    Blood 114:2952-60. 2009
    ..Mndal is highly polymorphic among inbred mouse strains, because it is absent in 10 of 24 strains. This polymorphism may have implications for other disease modifiers mapping to the same region...
  47. ncbi Unusual locations of involvement by malignancies: Case 1. Testicular plasmacytoma
    Atif Shafqat
    Indiana University School of Medicine, Indianapolis, USA
    J Clin Oncol 21:3368-9. 2003
  48. ncbi CT and MR imaging of solitary extramedullary plasmacytoma of the nasal tract
    Alex Sik Chung Ching
    Department of Diagnostic Imaging, National Cancer Centre, Singapore, Singapore
    AJNR Am J Neuroradiol 23:1632-6. 2002
    Solitary extramedullary plasmacytoma (SEP) is rare. The purpose of this study was to determine the CT and MR imaging features of SEP of the nasal tract.
  49. pmc Nodal and extranodal plasmacytomas expressing immunoglobulin a: an indolent lymphoproliferative disorder with a low risk of clinical progression
    Haipeng Shao
    Laboratory of Pathology and the Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Surg Pathol 34:1425-35. 2010
    ..In this study, 9 cases of IgA-positive plasmacytoma presenting in lymph node and 3 in extranodal sites were analyzed by morphology, immunohistochemistry, and ..
  50. ncbi Recurrence of multiple myeloma with soft tissue plasmacytoma presenting as unilateral proptosis
    Shin Wei Pan
    Department of Ophthalmology, Universiti Sains Malaysia, Health Campus, Kelantan, Malaysia
    Orbit 30:105-7. 2011
    To describe a rare case of soft tissue plasmacytoma of the orbit presenting with proptosis.
  51. ncbi Solitary plasmacytoma: is radiation therapy sufficient?
    Shaji Kumar
    Am J Hematol 83:695-6. 2008
  52. ncbi Solitary plasmacytoma of the thoracic vertebra presenting with sudden paraplegia and back pain: a pathologic case report
    Tadashi Terada
    Department of Pathology, Shizuoka City Shimizu Hospital, Miyakami 1231 Shimizu Ku, Shizuoka 424 8636, Japan
    Pathol Oncol Res 17:167-9. 2011
    Solitary plasmacytoma (SPC) accounts for 5% of plasma cell neoplasm. SPC of the spine is relatively rare, and SPC presenting with sudden paraplegia is very rare...
  53. ncbi Triple manifestation of extramedullary plasmacytoma in the upper airway: an unusual clinical entity
    I Morariu
    Department of Otolaryngology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland
    J Laryngol Otol 125:970-2. 2011
    We report an extremely rare case of extramedullary plasmacytoma.
  54. ncbi Extramedullary sites of involvement in hematologic malignancies: case 3. Hemorrhagic gastric plasmacytoma as the primary presentation in multiple myeloma
    C S Chim
    Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Clin Oncol 20:344-7. 2002
  55. ncbi [Extramedullary plasmacytoma of the larynx. A case report]
    Isabel González Guijarro
    Servicio de Otorrinolaringologia, Hospital Xeral Cies de Vigo, Espana
    Acta Otorrinolaringol Esp 62:320-2. 2011
    Extramedullary plasmacytoma of the larynx and localized laryngeal amyloidosis are two entities that are extremely rare in children...
  56. ncbi Case report: Solitary plasmacytoma of bone with oncogenic osteomalacia: recurrence of tumour confirmed by PET/CT. A case report with a review of the radiological literature
    S C Chua
    Department of Radiology and Nuclear Medicine, Queen s Campus, Nottingham University Hospital, Derby Road, Nottingham, UK
    Br J Radiol 81:e110-4. 2008
    We describe a case of oncogenic osteomalacia secondary to solitary plasmacytoma of the vertebral body of T3. The patient presented with symptoms of hypophosphataemia...
  57. ncbi Plasmablastic lymphoma may occur as a high-grade transformation from plasmacytoma
    Xin Qing
    Department of Pathology, Harbor UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USA
    Exp Mol Pathol 90:85-90. 2011
    ..chain restriction, but without EBER expression, raising the possibility of a preexisting or concurrent plasmacytoma and that the PBL may be a high-grade transformation from a preexisting plasma cell neoplasm following Epstein-..
  58. ncbi Secondary extramedullary plasmacytoma involving the pancreas
    Shizuhiro Hirata
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Hepatobiliary Pancreat Surg 9:111-5. 2002
    Extramedullary plasmacytoma is a rare variant of plasma cell tumor involving organs outside the bone marrow. The vast majority of extramedullary plasmacytomas present as a secondary tumor of systemic myelomatosis of the bone marrow...
  59. ncbi Prognostic value of angiogenesis in solitary bone plasmacytoma
    Shaji Kumar
    Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Blood 101:1715-7. 2003
    ..Solitary plasmacytoma is a localized plasma cell malignancy that progresses to MM in a significant number of patients...
  60. ncbi Extramedullary plasmacytoma involving the abdominal vessels and pancreas
    Ridvan Ali
    Dig Dis Sci 52:3199-201. 2007
  61. ncbi Bilateral plasmacytoma of the breast: a case report
    Rachel F Brem
    Department of Radiology, Breast Imaging and Intervention Center, George Washington University, Washington, DC 20037, USA
    Breast J 8:393-5. 2002
    b>Plasmacytoma of the breast is a rare condition that may occur as a solitary finding or in association with multiple myeloma. Of the cases of plasmacytoma of the breast that have been described, nearly half have been bilateral...
  62. ncbi Extramedullary plasmacytoma of the larynx presenting with upper airway obstruction in a patient with long-standing IgD myeloma
    H S Uppal
    Department of Otolaryngology, Head and Neck Surgery, Russells Hall Hospital, Dudley, UK
    J Laryngol Otol 115:745-6. 2001
    A rare case of upper airway obstruction due to an extramedullary plasmacytoma of the larynx in a patient with long-standing IgD myeloma is presented...
  63. ncbi Persistence of myeloma protein for more than one year after radiotherapy is an adverse prognostic factor in solitary plasmacytoma of bone
    Richard B Wilder
    Department of Radiation Oncology, M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 94:1532-7. 2002
    Prognostic factors for solitary plasmacytoma of bone (SPB), whether measured before or after radiotherapy (RT), have not been established...
  64. ncbi Pancreatic plasmacytoma presenting as variceal hemorrhage: life threatening complication of a rare entity
    Muslim Atiq
    Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    JOP 10:187-8. 2009
    Pancreatic plasmacytoma is a rare entity and presents with features of mass lesion of pancreas.
  65. ncbi Bortezomib in treatment of extramedullary plasmacytoma of the pancreas
    Ju Ying Wei
    Department of Hematology, Institute of Hematology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    Hepatobiliary Pancreat Dis Int 8:329-31. 2009
    Extramedullary pancreatic plasmacytoma treated with bortezomib is rarely reported.
  66. ncbi Prognosis and expression of lambda light chains in solitary extramedullary plasmacytoma of the head and neck: two case reports and a literature review
    H Y Liu
    Department of Otolaryngology, Zhejiang University, Hangzhou, China
    J Int Med Res 38:282-8. 2010
    Two cases of extramedullary plasmacytoma (EMP) of the head and neck, an uncommon plasma cell neoplasm, were studied. Both patients had good outcomes and have been followed for 17 and 12 years without recurrence or systemic disease...
  67. ncbi Extramedullary plasmacytoma of the larynx
    Takahiro Nakashima
    Department of Otolaryngology, Miyazaki Medical College, Miyazaki, Japan
    Auris Nasus Larynx 33:219-22. 2006
    Extramedullary plasmacytoma (EMP) is a rare plasma cell neoplasm that occurs in the soft tissues, especially in the upper airways...
  68. ncbi Extramedullary plasmacytoma arising from the lacrimal gland
    David I T Sia
    South Australian Institute of Ophthalmology, Adelaide, South Australia, Australia
    Clin Experiment Ophthalmol 38:895-8. 2010
    ..The lesion was excised and histology confirmed an orbital plasmacytoma. Multiple myeloma screening was negative and a solitary extramedullary plasmacytoma arising from the lacrimal ..
  69. ncbi Primary pancreatic plasmacytoma
    Yasunori Deguchi
    Department of Surgery, Shiga Medical Center for Adults, Moriyama, Shiga, Japan
    Am J Clin Oncol 27:247-9. 2004
    We report an extremely rare case of primary pancreatic plasmacytoma. A 56-year-old man had a 4-cm mass in the pancreatic tail and received distal pancreatectomy...
  70. ncbi Extramedullary plasmacytoma of nasopharynx and larynx: synchronous presentation
    Ozlem Yavas
    Am J Hematol 75:264-5. 2004
  71. ncbi Extramedullary plasmacytoma of the pancreas and jejunum
    Pramod Gupta
    Radiology Service, Dallas VA Medical Center, VA North Texas Health Care System, Dallas, TX 75216, USA
    Clin Imaging 33:240-3. 2009
    Plasmacytomas occurring in the gastrointestinal tract are extremely rare. We report one such case of pancreatic and jejunal plasmacytoma in a single patient with known multiple myeloma with emphasis on computed tomographic (CT) findings.
  72. ncbi Extraosseus plasmacytoma of the pharynx with localized light chain deposition. Case report
    Nina Zidar
    Institute of Pathology, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000, Ljubljana, Slovenia
    Pathol Oncol Res 16:249-52. 2010
    ..an isolated form of LCDD, which was limited to the pharyngeal mucosa and was associated with an extraosseus plasmacytoma of the pharynx, expanding the spectrum that has been recognized for LCDD...
  73. pmc Constitutive NF-kappaB activation confers interleukin 6 (IL6) independence and resistance to dexamethasone and Janus kinase inhibitor INCB018424 in murine plasmacytoma cells
    Yanqiang Yang
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 286:27988-97. 2011
    ..1-encoded Tax protein, which resembles K13 in inducing constitutive NF-κB activation, similarly protected plasmacytoma cells against IL6 withdrawal-induced apoptosis...
  74. ncbi Radiotherapy in the management of solitary extramedullary plasmacytoma
    M W Chao
    Radiation Oncology Victoria, Royal Melbourne Hospital, Melbourne, Victoria 3002, Australia
    Intern Med J 35:211-5. 2005
    Solitary extramedullary plasmacytoma (SEP) is a rare tumour for which the standard treatment remains local radiotherapy (RT)...
  75. ncbi Positron emission tomography (PET) for staging of solitary plasmacytoma
    Holger Schirrmeister
    Department of Nuclear Medicine, University of Ulm, Germany
    Cancer Biother Radiopharm 18:841-5. 2003
    This study was undertaken to investigate the clinical value in staging patients with plasmacytoma (PC) using positron emission tomography (PET).
  76. ncbi Sustained remission including marked regression of a paravertebral plasmacytoma in a patient with heavily pretreated, relapsed multiple myeloma after treatment with bortezomib
    Maria Theresa Krauth
    Department of Internal Medicine I, Clinical Division of Oncology, Bone marrow transplantation and Hematology and Hemostaseology, Medical University of Vienna, Austria
    Leuk Res 29:1473-7. 2005
    ..After three cycles of bortezomib, the patient achieved near-complete remission, as well as a nearly complete regression of the paravertebral tumor. This case further documents that bortezomib is an effective novel therapy for MM...
  77. ncbi Spontaneous rupture of liver plasmacytoma mimicking hepatocellular carcinoma
    Kosuke Ueda
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto
    Intern Med 49:653-7. 2010
    Extramedullary plasmacytoma of the liver is rare. Here, we report a case presenting with rupture of extramedullary plasmacytoma of the liver. She had a past history of multiple myeloma with IgA lambda type...
  78. ncbi Extramedullary plasmacytoma involving perirenal space accompanied by extramedullary hematopoiesis and amyloid deposition
    Rie Mimura
    Department of Radiology, Hakodate City Hospital, Hakodate, Japan
    Jpn J Radiol 28:309-13. 2010
    ..Pathological diagnosis of the biopsy specimen was extramedullary plasmacytoma accompanied by extramedullary hematopoiesis and amyloid deposition...
  79. ncbi Prostaglandins, but not tumor-derived IL-10, shut down concomitant tumor-specific CTL responses during murine plasmacytoma progression
    C Specht
    Institute for Immunology, , , Germany
    Int J Cancer 91:705-12. 2001
    ..The immunosuppressive role of tumor-derived IL-10 was analyzed using the MHC class II-negative BALB/c plasmacytoma ADJ-PC-5 as a model tumor...
  80. ncbi Primary testicular plasmacytoma with hydrocele of the testis
    K Suzuki
    Department of Urology, Jichi Medical School, Tochigi, Japan
    Int J Urol 8:139-40. 2001
    A case of primary testicular plasmacytoma complicated with hydrocele of the testis is reported. An 86-year-old man presented with hydrocele of the right testis...
  81. ncbi An unusual presentation of extramedullary plasmacytoma in testis and review of the literature
    H Mehmet Turk
    Department of Clinical Oncology, Faculty of Medicine, Gaziantep University, Gaziantep, 27310, Turkey
    Med Oncol 27:1378-80. 2010
    Extramedullary plasmacytoma is a rare plasma cell neoplasm, and it is extremely uncommon in the testicles. We report a 73-year-old man with multiple myeloma presented with testicular plasmacytoma...
  82. ncbi Neurological recovery from pentaplegia after resection for sacral plasmacytoma presenting with POEMS syndrome
    Yoshihisa Kotani
    Department of Orthopaedic Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Neurosurg Spine 10:324-8. 2009
    ..developed with neurological respiratory failure due to POEMS syndrome associated with a solitary sacral plasmacytoma. Resection was finally performed after her condition proved resistant to radiation and chemotherapy...
  83. ncbi Testicular plasmacytoma with bone dissemination without medullary plasmacytosis
    T Y Hou
    Division of Hematology Oncology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, No 325, Section 2, Cheng Kung Road, Neihu 114, Taipei, Taiwan
    Ann Hematol 82:518-20. 2003
    A 34-year-old man was diagnosed as having solitary testicular plasmacytoma. He had received palliative radiotherapy, several combined chemotherapies including CHOP chemotherapy (vincristine, cyclophosphamide, Adriamycin, and prednisone), ..
  84. ncbi High-dose recombinant interleukin-18 induces an effective Th1 immune response to murine MOPC-315 plasmacytoma
    Zdenka L Jonak
    GlaxoSmithKline Pharmaceuticals, King of Prussia, PA 19406, USA
    J Immunother 25:S20-7. 2002
    ..Therefore, this provides a convenient pharmacodynamic reference to the biologic response to IL-18 that may serve to guide the conduct of clinical trials...
  85. ncbi The bisphosphonate zoledronic acid inhibits the development of plasmacytoma induced in BALB/c mice by intraperitoneal injection of pristane
    Ferit Avcu
    Department of Hematology, Gulhane Military Medical Academy, Ankara, Turkey
    Eur J Haematol 74:496-500. 2005
    ..We have investigated the effect of the potent bisphosphonate, zoledronic acid (ZOL), on the development of pristane (2,6,10,14-tetramethylpentadecane)-induced plasmacytoma (PCT) in six-week-old BALB/c mice.
  86. ncbi Up-date on solitary plasmacytoma and its main differences with multiple myeloma
    P Di Micco
    Thrombosis Center, Instituto Clinico Humanitas, Milan, Italy
    Exp Oncol 27:7-12. 2005
    Solitary plasmacytoma is plasma cell neoplasm. It is a localized bone disease and for this reason it is different from multiple myeloma (systemic plasma cell neoplasm)...
  87. pmc Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in E(mu)-v-abl transgenic mice
    R C Andrew Symons
    The Walter and Eliza Hall Institute of Medical Research, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 99:11299-304. 2002
    There is a great difference in susceptibility to v-abl transgene-induced plasmacytoma between the BALB/cAn and the relatively resistant C57BL/6J mouse strains...
  88. ncbi Side effects and good effects from new chemotherapeutic agents. Case 3. Bortezomib in primary refractory plasmacytoma
    C S Chim
    University Departments of Medicine, Radiology and Pathology, Queen Mary Hospital, University of Hong Kong, Hong Kong
    J Clin Oncol 23:2426-8. 2005
  89. ncbi Outcomes and patterns of failure in solitary plasmacytoma: a multicenter Rare Cancer Network study of 258 patients
    Mahmut Ozsahin
    Department of Radiation Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Int J Radiat Oncol Biol Phys 64:210-7. 2006
    To assess the outcomes and patterns of failure in solitary plasmacytoma (SP).
  90. ncbi Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis
    Marcus Kremer
    Institute of Pathology, Technical University of Munich, Munich, Germany
    J Pathol 205:92-101. 2005
    ..Twenty-eight cases of primary extramedullary plasmacytoma and 26 cases of both medullary (n = 17) and extramedullary (n = 9) multiple myeloma were analysed for the ..
  91. ncbi Plasmacytoma in the breast with axillary lymph node involvement: a case report
    Lesley Taylor
    Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10016, USA
    Clin Breast Cancer 7:81-4. 2006
    ..We discuss management of a 78-year-old man with plasmacytoma in the breast who underwent a left total mastectomy and axillary lymph node dissection...
  92. ncbi Plasmacytoma of the mandible associated with a dental implant failure: a clinical report
    Carlo E Poggio
    School of Dentistry, Istituto Stomatologico Italiano, Universita degli Studi di Milano, Milan, Italy
    Clin Oral Implants Res 18:540-3. 2007
    The case report of a patient is presented who had been suffering from a plasmacytoma of the spine several years back, and who had developed a new plasmacytoma of the mandible, 3 years subsequent to the insertion of a dental implant...
  93. ncbi Solitary plasmacytoma and extramedullary plasmacytoma of the paranasal sinuses and soft palate
    S Majumdar
    Department of Otorhinolaryngology, University Hospital, Nottingham NG7 2UH, UK
    J Laryngol Otol 116:962-5. 2002
    Solitary plasmacytoma of the paranasal sinuses are uncommon neoplasms of B lymphocyte origin. They comprise one per cent of all head and neck tumours of the upper respiratory tract...
  94. pmc NOTCH is part of the transcriptional network regulating cell growth and survival in mouse plasmacytomas
    Dong Mi Shin
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, NIH, Rockville, Maryland 20852, USA
    Cancer Res 68:9202-11. 2008
    ....
  95. pmc Mouse plasmacytoma-expressed transcript 1 knock out induced 5-HT disruption results in a lack of cognitive deficits and an anxiety phenotype complicated by hypoactivity and defensiveness
    T L Schaefer
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Neuroscience 164:1431-43. 2009
    ..Lack of differences may be the result of compensatory mechanisms in reaction to a constitutive knock out of Pet-1 or 5-HT may not be as important in learning and memory as previously suspected...
  96. ncbi Solitary plasmacytoma treated with radiotherapy: impact of tumor size on outcome
    R W Tsang
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, 610 University Avenue, Toronto, Ontario, M5G 2M9 Canada
    Int J Radiat Oncol Biol Phys 50:113-20. 2001
    Solitary plasmacytoma (SP) is a rare presentation of plasma cell neoplasms...
  97. ncbi Solitary plasmacytoma of bone and soft tissue
    T W Bolek
    Department of Radiation Oncology, University of Florida, College of Medicine, Gainesville, USA
    Int J Radiat Oncol Biol Phys 36:329-33. 1996
    This retrospective review evaluates the results of radiotherapy used for curative intent in the management of solitary plasmacytoma.
  98. ncbi Solitary plasmacytoma of bone and extramedullary plasmacytoma
    M A Dimopoulos
    Department of Clinical Therapeutics, University of Athens School of Medicine, Greece
    Hematol Oncol Clin North Am 13:1249-57. 1999
    A small proportion of patients with plasma cell myeloma have a solitary plasmacytoma of bone...
  99. ncbi Improved outcome in solitary bone plasmacytomata with combined therapy
    A Aviles
    Department of Hematology, Oncology Hospital, National Medical Center, Mexico, D F Mexico, USA
    Hematol Oncol 14:111-7. 1996
    Solitary bone plasmacytoma (SBP) is a rare presentation of plasma cell dyscrasias...
  100. ncbi Primary pulmonary plasmacytoma: a case report
    J N Wise
    Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
    Chest 120:1405-7. 2001
    ..The patient in our case report is the first to experience renal failure due to hematologic monoclonal gammopathy. Postoperatively, serum protein electrophoresis reverted to normal...
  101. pmc Somatostatin receptor scintigraphy might be useful for detecting skeleton abnormalities in patients with multiple myeloma and plasmacytoma
    Ali Agool
    Department of Nuclear Medicine and Molecular Imaging, University of Groningen and University Medical Centre Groningen, Groningen, The Netherlands
    Eur J Nucl Med Mol Imaging 37:124-30. 2010
    ..Somatostatin receptor expression has been demonstrated on a number of plasma cell lines. Therefore, we questioned whether somatostatin receptor scintigraphy (SRS) can be used to demonstrate in vivo multiple myeloma (MM) activity...

Research Grants39

  1. Lysophosphatidic Acid in Oncogenesis
    Xianjun Fang; Fiscal Year: 2010
    ..The tumors include malignant lymphoma, lung adenocarcinoma, high-grade sarcoma, leiomyosarcoma, plasmacytoma and pilomatrixoma...
  2. Defining genetic pathways of plasma-cell neoplasia
    Siegfried Janz; Fiscal Year: 2013
    ..transgenic mouse, a gene-insertion model of the Myc-activating T(12;15) translocation in mouse plasmacytoma. Aim 3 is devoted to validating the newly discovered driver genes, including the involvement of their human ..
  3. INTERACTION OF AMINOTHIOLS AND ALKYLATING AGENTS
    Frederick Valeriote; Fiscal Year: 1990
    ..will be examined using other murine leukemia and solid tumor models, specifically L1210 Leukemia, MOCP-315 plasmacytoma, Lewis Lung Carcinoma and Colon 36. A normal cell population the hematopoietic stem cell, will be examined also...
  4. ANALYSIS OF IDIOTYPE MUTANTS
    Heinz Kohler; Fiscal Year: 1980
    The S107 BALB/c plasmacytoma tumor produces an IgA myeloma protein which has specificity for the hapten phosphorylcholine (PC)...
  5. SYNERGY OF TUMOR CHEMOTHERAPY AND HOST IMMUMITY
    SHELDON DRAY; Fiscal Year: 1991
    ..tolerable dose of cyclophosphamide or melphalan cures a BALB/c mouse bearing a large subcutaneous MOPC-315 plasmacytoma and extensive metastases at a late stage of tumor growth, yet the same dose of drug has little or no curative ..
  6. Chromatin Insulator Function at the C-myc Gene
    Anton Krumm; Fiscal Year: 2007
    The hallmark of Burkitt Lymphoma and murine plasmacytoma cells is the translocation of the c-myc oncogene to one of the immunoglobulin gene loci that harbor B-cell specific enhancer elements...
  7. PLASMACYTOMA RESISTANCE TO ALKYLATING AGENTS
    Carmelita Frondoza; Fiscal Year: 1993
    ..an active analog of CY, we observed that drug transport is identical in CY resistant and sensitive mouse LPC-1 plasmacytoma but drug metabolism is different in these two tumor lines...
  8. STROMAL CYTOKINE SIGNALING AND BIOLOGICAL FUNCTIONS
    Yu Chung Yang; Fiscal Year: 2001
    ..fibroblast cell line based on the ability of the cytokine to stimulate the proliferation of an IL-6-dependent plasmacytoma cell line...
  9. DEVELOPMENTAL CONTROL OF IMMUNOGLOBULIN TRANSCRIPTION
    Michael Atchison; Fiscal Year: 2005
    ..Pip dominant negative mutants will be tested for ability to inhibit endogenous kappa gene expression in plasmacytoma cells...
  10. MECHANISM OF MELPHALAN-MEDIATED TUMOR ERADICATION
    MARGALIT MOKYR; Fiscal Year: 1990
    ..We know already that the immunomodulatory activity of a low dose of this alkylating agent consists, in some plasmacytoma tumor models, not only of elimination of suppressor cell activity, but also of induction of appearance of ..
  11. MECHANISM OF MELPHALAN-MEDIATED TUMOR ERADICATION
    MARGALIT MOKYR; Fiscal Year: 1992
    ..We know already that the immunomodulatory activity of a low dose of this alkylating agent consists, in some plasmacytoma tumor models, not only of elimination of suppressor cell activity, but also of induction of appearance of ..
  12. Induction of CIITA expression in B cells and myeloma
    Vladimir Mayorov; Fiscal Year: 2006
    ..The B cell malignancies, multiple myeloma and plasmacytoma, and also other types of tumors escape destruction by the immune system because they do not express CIITA...
  13. ONCOGENE INDUCED LEUKEMOGENESIS IN TRANGENIC MICE
    Suzanne Cory; Fiscal Year: 2009
    ..of Bim, Noxa or Puma accelerates malignant transformation of plasma cells, crosses will be performed between plasmacytoma-prone v-ab/ mice and BH3-only 'knockout'mice...
  14. HUMAN MONOCLONAL ANTIBODIES PRODUCED IN SCID MICE
    RAYMOND KELLEHER; Fiscal Year: 1990
    ..Human PBL populating the spleen of immunized animals will be fused with the murine plasmacytoma cell line P3X63.Ag8.653 using PEG, and the resultant hybridomas selected in HAT-containing medium...
  15. STRUCTURE AND GENETICS OF ANTIBODY VARIABLE REGIONS
    LOVICK CANNON; Fiscal Year: 1980
    ..products obtained by in vitro cell-fusion of immune spleen cells and antigen-simulated spleen fragments with plasmacytoma cells...
  16. CELL CYCLE AND APOPTOSIS IN PLASMA CELL TUMORIGENESIS
    Selina Chen Kiang; Fiscal Year: 2003
    ..Accumulation of non-cycling plasmacytoma cells was preceded by a marked expansion of activated B cells...
  17. C-MYC PROTOONCOGENE TRANSCRIPTIONAL ELONGATION
    Mark Groudine; Fiscal Year: 2000
    ..In human Burkett's lymphoma (BL) and murine plasmacytoma cells, which are characterized by translocations that juxtapose c-myc and immunoglobulin (ig) sequences, the c-..
  18. MDM2 ONCOPROTEIN AS A CELL REGULATOR OF P53
    STEVEN BERBERICH; Fiscal Year: 1999
    ..first aim of this proposal will be to assay the effects of the various Mdm-2 proteins produced from a murine plasmacytoma cell line harboring a novel mdm-2 translocation...
  19. IMMUNOLOGICAL ANALYSIS OF THE MAMMALIAN VISUAL SYSTEM
    Colin Barnstable; Fiscal Year: 1991
    ..Spleen cells will be taken from mice mounting an adequate immune response and fused with a mouse plasmacytoma. In addition spleen cells will be immunised by in vitro incubation with antigen and then fused...
  20. Phase II Trial of Thalidomide in Primary Amyloidosis
    Angela Dispenzieri; Fiscal Year: 2002
    ..The ultimate goal of the proposed studies is to improve the prognosis of patient with this fatal disease. ..
  21. B7-CD28/CTLA-4 INTERACTIONS IN IMMUNITY TO TUMORS
    MARGALIT MOKYR; Fiscal Year: 2001
    ..This information will in turn facilitate the design of rational approaches to manipulate this key immunoregulatory pathway to the benefit of the tumor bearers. ..
  22. Cytokine Polymorphisms and Hodgkin Lymphoma Risk
    Wendy Cozen; Fiscal Year: 2006
    ..This study is important since it may will lead to identification of causal genetic factors which may offer alternative therapeutic strategies or prevention. ..
  23. Targeting AID to Overcome Antigenic Drift
    Xue Feng Bai; Fiscal Year: 2006
    ..T cells specific for a natural tumor rejection antigen P1A (P1CTL) to treat mice with large established plasmacytoma J558 tumors, we found that P1CTL selected high numbers of mutations in the P1A antigenic epitope, known as ..
  24. EBV SPECIFIC THERAPY OF LYMPHOMA USING DENDRITIC CELLS
    Madhav Dhodapkar; Fiscal Year: 2002
    ..abstract_text> ..
  25. Inflammatory cytokine-mediated induction of HIV cardiomyopathy
    Jennifer Yearley; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  26. Adult Hodgkin's Disease and Epstein Barr Virus
    Richard Ambinder; Fiscal Year: 2006
    ..This work should lay the groundwork for future viral antigen targeted therapies. ..
  27. Risk Factors for Non Hodgkin's Lymphoma in Twins
    Wendy Cozen; Fiscal Year: 2006
    ..6 and as high as 1.8. A matched case-control analysis using SAS will be performed using multivariate logistic regression. [unreadable] [unreadable]..
  28. Migration of Mature and Immature Dendritic Cells
    HENDRIK VAN DEVENTER; Fiscal Year: 2006
    ..All have extensive experience in developing the careers o f young scientists. This work has the support of the Lineberger Comprehensive Cancer Center which has made accessible its core facilities. ..
  29. Treatment of Early Stage Multiple Myeloma
    S Rajkumar; Fiscal Year: 2006
    ..BM angiogenesis will be studied using immunostaining (IHC) for CD34 and an in vitro human angiogenesis assay. VEGF expression will be studied using IHC and quantitative RT-PCR. ..
  30. Quantitative RT-PCR: Prediction Lymphoma Transformation
    Kojo Elenitoba Johnson; Fiscal Year: 2005
    ....
  31. Opioid Dependence, Immunity and Infection
    TOBY EISENSTEIN; Fiscal Year: 2005
    ..Dissection of the mechanisms and pathways by which opioids interface with the immune system during withdrawal should elucidate fundamental interconnections between the neural and immune systems. ..
  32. OPIOIDS, OPIOID RECEPTORS, AND SEPSIS
    TOBY EISENSTEIN; Fiscal Year: 2001
    ..It relates to events associated with both the therapeutic and non-therapeutic use of morphine and other opioid drugs. ..
  33. Angiogenesis and thalidomide therapy in multiple myeloma
    S Rajkumar; Fiscal Year: 2004
    ..This study offers a unique opportunity to serially study tumor cells and the tumor microenvironment following potential anti-angiogenic therapy. ..
  34. TERMINAL STAGES OF APOPTOSIS: RECONSTITUTION AND MECHAN
    WILLIAM GARRARD; Fiscal Year: 2004
    ..Identify DFF45 interaction surface(s) b. Identify homo-oligomerization interaction surfaces c. Locate the endonuclease active site d. Create auto-activated forms of DFF40 e. Create dominant-negative species ..
  35. RISK FACTORS FOR YOUNG ADULT HODGKIN'S DISEASE IN TWINS
    Wendy Cozen; Fiscal Year: 2004
    ..6 and as high as 2.0 at 80% power. A matched case-control analysis will be performed using multivariate logistic regression in SAS. ..