follicular lymphoma

Summary

Summary: Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the lymph nodes. The nodules resemble to some extent the germinal centers of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-lymphocytes. This class of lymphoma usually occurs in older persons, is commonly multinodal, and possibly extranodal. Patients whose lymphomas present a follicular or nodular pattern generally have a more indolent course than those presenting with a diffuse pattern.

Top Publications

  1. ncbi Follicular lymphoma international prognostic index 2: a new prognostic index for follicular lymphoma developed by the international follicular lymphoma prognostic factor project
    Massimo Federico
    Dipartimento di Oncologia ed Ematologia, Universita di Modena e Reggio Emilia, Via del Pozzo 71, 41124 Modena, Italy
    J Clin Oncol 27:4555-62. 2009
  2. ncbi Follicular lymphoma international prognostic index
    Philippe Solal-Celigny
    Centre Jean Bernard, 9 rue Beauverger, 72000 Le Mans, France
    Blood 104:1258-65. 2004
  3. ncbi Expression of microRNAs in diffuse large B cell lymphoma is associated with immunophenotype, survival and transformation from follicular lymphoma
    Charles H Lawrie
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Cell Mol Med 13:1248-60. 2009
  4. ncbi Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones
    Marianne Brodtkorb Eide
    Centre for Cancer Biomedicine, University of Oslo, Norway
    Blood 116:1489-97. 2010
  5. pmc Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
    Lucia Conde
    School of Public Health, University of California, Berkeley, Berkeley, California, USA
    Nat Genet 42:661-4. 2010
  6. ncbi Phase III study of R-CVP compared with cyclophosphamide, vincristine, and prednisone alone in patients with previously untreated advanced follicular lymphoma
    Robert Marcus
    Department of Haematology, Addenbrooke s Hospital, Cambridge, UK
    J Clin Oncol 26:4579-86. 2008
  7. pmc Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA
    Nat Genet 41:873-5. 2009
  8. ncbi Transformation of follicular lymphoma to diffuse large B-cell lymphoma may occur by divergent evolution from a common progenitor cell or by direct evolution from the follicular lymphoma clone
    Emanuela Carlotti
    Centre for Medical Oncology Laboratory, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Blood 113:3553-7. 2009
  9. ncbi Phase I study of inotuzumab ozogamicin (CMC-544) in Japanese patients with follicular lymphoma pretreated with rituximab-based therapy
    Michinori Ogura
    Department of Hematology and Oncology, Nagoya Daini Red Cross Hospital, Nagoya, Japan
    Cancer Sci 101:1840-5. 2010
  10. ncbi Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular lymphoma
    Koen Van Besien
    Lymphoma Working Committee, International Bone Marrow Transplant Registry Autologous Blood and Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, Milwaukee, USA
    Blood 102:3521-9. 2003

Detail Information

Publications324 found, 100 shown here

  1. ncbi Follicular lymphoma international prognostic index 2: a new prognostic index for follicular lymphoma developed by the international follicular lymphoma prognostic factor project
    Massimo Federico
    Dipartimento di Oncologia ed Ematologia, Universita di Modena e Reggio Emilia, Via del Pozzo 71, 41124 Modena, Italy
    J Clin Oncol 27:4555-62. 2009
    ..a prospective collection of data would enable the development of a more accurate prognostic index for follicular lymphoma (FL) by using parameters which could not be retrospectively studied before, and by choosing progression-..
  2. ncbi Follicular lymphoma international prognostic index
    Philippe Solal-Celigny
    Centre Jean Bernard, 9 rue Beauverger, 72000 Le Mans, France
    Blood 104:1258-65. 2004
    ..3), and poor risk (> or = 3 adverse factors, 27% of patients, HR = 4.3). This Follicular Lymphoma International Prognostic Index (FLIPI) appeared more discriminant than the International Prognostic Index ..
  3. ncbi Expression of microRNAs in diffuse large B cell lymphoma is associated with immunophenotype, survival and transformation from follicular lymphoma
    Charles H Lawrie
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Cell Mol Med 13:1248-60. 2009
    ..microRNA expression in two of the most common lymphomas: diffuse large B-cell lymphoma (DLBCL) (n = 80) and follicular lymphoma (FCL) (n = 18) using microarrays containing probes for 464 human microRNAs...
  4. ncbi Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones
    Marianne Brodtkorb Eide
    Centre for Cancer Biomedicine, University of Oslo, Norway
    Blood 116:1489-97. 2010
    Our aim was to examine the genetics of clonal evolution in follicular lymphoma (FL) and to identify genetic alterations associated with disease progression...
  5. pmc Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
    Lucia Conde
    School of Public Health, University of California, Berkeley, Berkeley, California, USA
    Nat Genet 42:661-4. 2010
    ..We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1...
  6. ncbi Phase III study of R-CVP compared with cyclophosphamide, vincristine, and prednisone alone in patients with previously untreated advanced follicular lymphoma
    Robert Marcus
    Department of Haematology, Addenbrooke s Hospital, Cambridge, UK
    J Clin Oncol 26:4579-86. 2008
    To compare the long-term outcome of patients with previously untreated follicular lymphoma (FL) needing therapy, after treatment with cyclophosphamide, vincristine and prednisone (CVP) versus CVP plus rituximab (R-CVP) and to evaluate ..
  7. pmc Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA
    Nat Genet 41:873-5. 2009
    ..We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined ..
  8. ncbi Transformation of follicular lymphoma to diffuse large B-cell lymphoma may occur by divergent evolution from a common progenitor cell or by direct evolution from the follicular lymphoma clone
    Emanuela Carlotti
    Centre for Medical Oncology Laboratory, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Blood 113:3553-7. 2009
    ..On the basis of the father/son model, this CPC must be long-lived, providing a possible explanation for the incurable nature of this disease...
  9. ncbi Phase I study of inotuzumab ozogamicin (CMC-544) in Japanese patients with follicular lymphoma pretreated with rituximab-based therapy
    Michinori Ogura
    Department of Hematology and Oncology, Nagoya Daini Red Cross Hospital, Nagoya, Japan
    Cancer Sci 101:1840-5. 2010
    ..3 and 1.8 mg/m(2)). All 13 patients had follicular lymphoma, were previously treated with > or =1 rituximab-alone or rituximab-containing chemotherapy, and were ..
  10. ncbi Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular lymphoma
    Koen Van Besien
    Lymphoma Working Committee, International Bone Marrow Transplant Registry Autologous Blood and Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, Milwaukee, USA
    Blood 102:3521-9. 2003
    In this article, we report on 904 patients undergoing transplantation for follicular lymphoma. A total of 176 (19%) received allogeneic, 131 (14%) received purged autologous, and 597 (67%) received unpurged autologous transplants...
  11. ncbi Prognosis of follicular lymphoma: a predictive model based on a retrospective analysis of 987 cases. Intergruppo Italiano Linfomi
    M Federico
    Oncologia Medica, Universita di Modena, Modena, Italia
    Blood 95:783-9. 2000
    Patients (n-987) with a histologically confirmed diagnosis of follicular lymphoma were studied with the aim of developing a prognostic model specifically devised for this type of lymphoma...
  12. ncbi 131I-tositumomab therapy as initial treatment for follicular lymphoma
    Mark S Kaminski
    Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical Center, Ann Arbor, MI 48109 0936, USA
    N Engl J Med 352:441-9. 2005
    ..Anti-CD20 radioimmunotherapy is effective in patients who have had a relapse after chemotherapy or who have refractory follicular lymphoma, but it has not been tested in previously untreated patients.
  13. ncbi New treatment options have changed the survival of patients with follicular lymphoma
    Richard I Fisher
    James P Wilmot Cancer Center, University of Rochester, Rochester, NY, USA
    J Clin Oncol 23:8447-52. 2005
    The natural history of follicular lymphoma is believed not to have changed over the last 30 years. Median survivals have ranged from 7 to 10 years, and the disease is considered incurable...
  14. ncbi Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma
    Alexandar Tzankov
    Department of Pathology, University Hospital Basel, Schoenbeinstr 40, CH 4031 Basel, Switzerland
    Haematologica 93:193-200. 2008
    ..The tumor microenvironment is important for the behavior of cancer. We assessed the distribution and biological significance of FOXP3(+) regulatory T-cells (Treg) in lymphomas...
  15. ncbi Eight-year experience with allogeneic stem cell transplantation for relapsed follicular lymphoma after nonmyeloablative conditioning with fludarabine, cyclophosphamide, and rituximab
    Issa F Khouri
    Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Blood 111:5530-6. 2008
    Nonmyeloablative stem cell transplantation in patients with follicular lymphoma has been designed to exploit the graft-versus-lymphoma immunity. The long-term effectiveness and toxicity of this strategy, however, is unknown...
  16. ncbi Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells
    Sandeep S Dave
    National Cancer Institute, NIH, Bethesda, MD 20892, USA
    N Engl J Med 351:2159-69. 2004
    Patients with follicular lymphoma may survive for periods of less than 1 year to more than 20 years after diagnosis...
  17. ncbi The architectural pattern of FOXP3-positive T cells in follicular lymphoma is an independent predictor of survival and histologic transformation
    Pedro Farinha
    Pathology and Laboratory Medicine, BC Cancer Agency Center for Lymphoid Cancers, Vancouver, BC, Canada
    Blood 115:289-95. 2010
    Previous studies of follicular lymphoma (FL) patients treated heterogeneously have suggested that decreased numbers of regulatory T cells correlates with improved survival...
  18. pmc Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins
    Vania Coelho
    Molecular Immunology Group, Cancer Sciences Division, University of Southampton, School of Medicine, Southampton SO16 6YD, United Kingdom
    Proc Natl Acad Sci U S A 107:18587-92. 2010
    Surface Ig (sIg) of follicular lymphoma (FL) is vital for tumor cell survival. We found previously that the Ig in FL is unusual, because the variable region genes carry sequence motifs for N-glycan addition...
  19. pmc Placebo-controlled phase III trial of patient-specific immunotherapy with mitumprotimut-T and granulocyte-macrophage colony-stimulating factor after rituximab in patients with follicular lymphoma
    Arnold Freedman
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 27:3036-43. 2009
    To evaluate patient-specific immunotherapy with mitumprotimut-T (idiotype keyhole limpet hemocyanin [Id-KLH]) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in CD20(+) follicular lymphoma.
  20. ncbi Syk-dependent mTOR activation in follicular lymphoma cells
    Ludivine Leseux
    INSERM U563 Centre de Physiopathologie Toulouse Purpan CPTP, Département d Oncogenèse et Signalisation dans les Cellules Hématopoïétiques, Centre Hospitalier Universitaire CHU Purpan BP3028, Toulouse, France
    Blood 108:4156-62. 2006
    ..This study shows that in follicular lymphoma (FL) cells, mTOR is active because the cells displayed rapamycin-sensitive phosphorylation of p70S6 kinase ..
  21. ncbi Long-term follow-up of high-dose treatment with autologous haematopoietic progenitor cell support in 693 patients with follicular lymphoma: an EBMT registry study
    S Montoto
    Cancer Research UK Medical Oncology Unit, Institute of Cancer, Centre for Medical Oncology, Barts and The London, Queen Mary s School of Medicine and Dentistry, London, UK
    Leukemia 21:2324-31. 2007
    To evaluate the outcome of a large series of patients who received high-dose treatment (HDT) for follicular lymphoma (FL), 693 patients undergoing HDT (total-body irradiation (TBI)-containing regimen: 58%; autologous bone marrow (BM)/..
  22. ncbi Myeloablative therapy with autologous bone marrow transplantation for follicular lymphoma at the time of second or subsequent remission: long-term follow-up
    Ama Z S Rohatiner
    Cancer Research UK Medical Oncology Unit, St Bartholomew s Hospital, London, United Kingdom
    J Clin Oncol 25:2554-9. 2007
    The aim of this retrospective analysis was to determine the outcome of patients with follicular lymphoma who received myeloablative therapy supported by autologous bone marrow transplantation as consolidation of second or subsequent ..
  23. ncbi Results of a phase I/II study of ocrelizumab, a fully humanized anti-CD20 mAb, in patients with relapsed/refractory follicular lymphoma
    F Morschhauser
    Department of Hematology, Claude Huriez Hospital, Lille, France
    Ann Oncol 21:1870-6. 2010
    ..This phase I/II study evaluated its safety and efficacy in patients with relapsed/refractory follicular lymphoma (FL) after prior rituximab therapy.
  24. pmc An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals
    Ramzi M Mohammad
    Division of Hematology and Oncology, Department of Internal Medicine, Karmanos Cancer Institute, Wayne State University School of Medicine, 732 HWCRC, 4100 John R Street, Detroit, Michigan 48201, USA
    Mol Cancer 8:115. 2009
    ..The purpose of this study was to evaluate anti-lymphoma activity of MI-319 in WSU-FSCCL, a B-cell follicular lymphoma line...
  25. pmc Anti-idiotype antibody response after vaccination correlates with better overall survival in follicular lymphoma
    Weiyun Z Ai
    Department of Medicine, Division of Hematology and Oncology, University of California, San Francisco, USA
    Blood 113:5743-6. 2009
    ..tumor-specific immune response is associated with superior clinical outcome in patients with follicular lymphoma. Here, we investigated whether this positive correlation extends to overall survival (OS)...
  26. ncbi Prospective, multicenter randomized GITMO/IIL trial comparing intensive (R-HDS) versus conventional (CHOP-R) chemoimmunotherapy in high-risk follicular lymphoma at diagnosis: the superior disease control of R-HDS does not translate into an overall surviva
    Marco Ladetto
    Divisione Universitaria di Ematologia, Cattedra di Ematologia, Torino, Italy
    Blood 111:4004-13. 2008
    ..R-HDS) to assess the value of intensified chemo-therapy as a first-line treatment for high-risk follicular lymphoma (FL) after the introduction of monoclonal antibodies...
  27. ncbi Clinical benefit associated with idiotypic vaccination in patients with follicular lymphoma
    Susana Inoges
    Lab of Immunotherapy, Oncology Division, Center for Applied Medical Research CIMA, Avda Pio XII, 55, 31008 Pamplona Navarra, Spain
    J Natl Cancer Inst 98:1292-301. 2006
    b>Follicular lymphoma is considered incurable, although cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy can induce sequential remissions...
  28. pmc A proliferation-inducing ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase-regulated mammalian target of rapamycin activation
    Mamta Gupta
    Mayo Clinic, Rochester, MN 55905, USA
    Blood 113:5206-16. 2009
    ..In support of murine studies, we find that APRIL induces proliferation of human patient follicular lymphoma (FL) B cells in a TACI-dependent manner...
  29. pmc Tumor suppressor gene methylation in follicular lymphoma: a comprehensive review
    John Hayslip
    Hollings Cancer Center, Medical University of South Carolina, Clinical Sciences Building Room 903, PO Box 250635, Charleston, SC 29425, USA
    Mol Cancer 5:44. 2006
    ..Earlier methylation studies of follicular lymphoma involved only cell lines; however there is a growing literature of methylation changes in primary human FL ..
  30. ncbi Prolonged clinical and molecular remission in patients with low-grade or follicular non-Hodgkin's lymphoma treated with rituximab plus CHOP chemotherapy: 9-year follow-up
    Myron S Czuczman
    Roswell Park Cancer Institute, Buffalo, NY, USA
    J Clin Oncol 22:4711-6. 2004
    ..Revised response rates based on International Workshop Response Criteria are also provided...
  31. ncbi Improved survival in patients with early stage low-grade follicular lymphoma treated with radiation: a Surveillance, Epidemiology, and End Results database analysis
    Thomas J Pugh
    Department of Radiation Oncology, University of Colorado Denver Comprehensive Cancer Center, Aurora, Colorado 80045 0508, USA
    Cancer 116:3843-51. 2010
    External beam radiation therapy (RT) is the standard treatment for stage I-II, grade 1-2 follicular lymphoma. Because of an indolent natural history, some advocate alternative management strategies, including watchful waiting for this ..
  32. ncbi Lack of Bcl-2 expression in follicular lymphoma may be caused by mutations in the BCL2 gene or by absence of the t(14;18) translocation
    Margit Schraders
    Department of Pathology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    J Pathol 205:329-35. 2005
    b>Follicular lymphoma (FL), except grade 3B, is characterized by the chromosomal translocation t(14;18)(q32;q21), which results in over-expression of the Bcl-2 protein...
  33. ncbi Implications of the tumor microenvironment on survival and disease response in follicular lymphoma
    John G Gribben
    Center for Experimental Cancer Medicine, Barts and the London School of Medicine, Queen Mary University of London, Institute of Cancer, Charterhouse Square, London, UK
    Curr Opin Oncol 22:424-30. 2010
    Although outcomes for patients with follicular lymphoma have improved with chemoimmunotherapy, the disease remains incurable...
  34. ncbi Human mesenchymal stem cells isolated from bone marrow and lymphoid organs support tumor B-cell growth: role of stromal cells in follicular lymphoma pathogenesis
    Patricia Ame-Thomas
    Unité Propre de Recherche de l Enseignement Superieur Equipe d Accueil 3889, Faculte de Medicine, Universite Rennes 1, and Département Hématologie Immunologie et Thérapie Cellulaire, Centre Hospitalo Universitaire Pontchaillou, France
    Blood 109:693-702. 2007
    Accumulating evidence indicates that the cellular microenvironment plays a key role in follicular lymphoma (FL) pathogenesis, both within tumor lymph nodes (LNs) and in infiltrated bone marrow where ectopic LN-like reticular cells are ..
  35. ncbi BCR-bound antigen is targeted to exosomes in human follicular lymphoma B-cells
    Pascale Rialland
    INSERM U520, Institut Curie, 26, rue d Ulm, 75 248 Paris cedex 05, France
    Biol Cell 98:491-501. 2006
    ..Exosomes have been well studied in EBV (Epstein-Barr virus)-transformed human B-cell lines; however, biological stimuli regulating exosome secretion quantitatively and/or qualitatively still remain poorly defined...
  36. pmc Humoral immune response and immunoglobulin G Fc receptor genotype are associated with better clinical outcome following idiotype vaccination in follicular lymphoma patients regardless of their response to induction chemotherapy
    Wen Kai Weng
    Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA 94305 5306, USA
    Blood 109:951-3. 2007
    ..and FcgammaRIIIa 158 valine/valine (V/V) genotype both correlate with better outcome in a group of 136 follicular lymphoma patients receiving idiotype vaccination after induction chemotherapy...
  37. ncbi Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program
    P McLaughlin
    Department of Hematology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Clin Oncol 16:2825-33. 1998
    ..It is appealing for targeted therapy, because it does not shed or modulate. A chimeric monoclonal antibody more effectively mediates host effector functions and is itself less immunogenic than are murine antibodies...
  38. pmc Transformation of follicular lymphoma to diffuse large B-cell lymphoma proceeds by distinct oncogenic mechanisms
    Andrew J Davies
    Cancer Research UK Medical Oncology Unit, St Bartholomew s Hospital, London, UK
    Br J Haematol 136:286-93. 2007
    ..to further elucidate the biological mechanisms underlying the frequent event of transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (t-FL)...
  39. ncbi Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NFkappaB activity in Follicular Lymphoma
    Michael R Green
    Genomics Research Centre, Griffith University, Queensland, Australia
    Leuk Res 33:1699-702. 2009
    ..Our results provide strong evidence that relative FOXP1 isoform abundance is associated with NFkappaB activity in FL, and could potentially be used as a marker for this gene signature...
  40. ncbi Long-term follow-up of patients with follicular lymphoma receiving single-agent rituximab at two different schedules in trial SAKK 35/98
    Giovanni Martinelli
    Istituto Europeo di Oncologia, Divisione di Ematologia, Milan, Italy
    J Clin Oncol 28:4480-4. 2010
    ..of a randomized clinical trial comparing induction therapy with once per week for 4 weeks single-agent rituximab alone versus induction followed by 4 cycles of maintenance therapy every 2 months in patients with follicular lymphoma.
  41. ncbi Validation, revision and extension of the Follicular Lymphoma International Prognostic Index (FLIPI) in a population-based setting
    S A M van de Schans
    Eindhoven Cancer Registry, Comprehensive Cancer Centre South, Eindhoven, The Netherlands
    Ann Oncol 20:1697-702. 2009
    The aim of this study was to validate the Follicular Lymphoma International Prognostic Index (FLIPI) in a population-based cohort and to study the relevance of revision and extension of the FLIPI.
  42. ncbi The role of cytotoxic therapy with hematopoietic stem cell transplantation in the treatment of follicular lymphoma: an evidence-based review
    Denise M Oliansky
    Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Biol Blood Marrow Transplant 16:443-68. 2010
    ..Treatment recommendations reached unanimously by a panel of follicular lymphoma experts are: (1) autologous SCT is recommended as salvage therapy based on pre-rituximab data, with a ..
  43. ncbi Utility of the Follicular Lymphoma International Prognostic Index and the International Prognostic Index in assessing prognosis and predicting first-line treatment efficacy in follicular lymphoma patients
    V Formica
    Department of Medicine, Royal Marsden Hospital, London and Sutton, UK
    Acta Haematol 122:193-9. 2009
    The Follicular Lymphoma International Prognostic Index (FLIPI) allows physicians to stratify patients into groups with distinct prognoses, however its ability to predict the treatment efficacy has not been fully investigated...
  44. ncbi 18F-fluoro-deoxy-glucose positron emission tomography (18F-FDG-PET) visualizes follicular lymphoma irrespective of grading
    S Wohrer
    Department of Internal Medicine I, Nuclear Medicine and Radiology, Medical University Vienna, Austria
    Ann Oncol 17:780-4. 2006
    ..We have investigated accuracy and clinical usefulness of 18F-FDG-PET in patients with follicular lymphoma (FL).
  45. ncbi Gastrointestinal follicular lymphoma: review of the literature
    Shuji Yamamoto
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto, 606 8507, Japan
    J Gastroenterol 45:370-88. 2010
    Gastrointestinal follicular lymphoma (GI-FL) is a relatively rare disease, accounting for only 1%-3.6% of gastrointestinal non-Hodgkin's lymphoma...
  46. ncbi Rituximab: a review of its use in chronic lymphocytic leukaemia, low-grade or follicular lymphoma and diffuse large B-cell lymphoma
    Gillian M Keating
    Adis, a Wolters Kluwer Business, Auckland, New Zealand
    Drugs 70:1445-76. 2010
    ..the use of intravenous rituximab in the treatment of chronic lymphocytic leukaemia (CLL), low-grade or follicular lymphoma, and diffuse large B-cell lymphoma...
  47. ncbi Long-term outcomes for patients with limited stage follicular lymphoma: involved regional radiotherapy versus involved node radiotherapy
    Belinda A Campbell
    Department of Radiation Oncology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Cancer 116:3797-806. 2010
    Given the indolent behavior of follicular lymphoma (FL), it is controversial whether limited stage FL can be cured using radiotherapy (RT). Furthermore, the optimal RT field size is unclear...
  48. ncbi Primary follicular lymphoma of the gastrointestinal tract: a study of 25 cases and a literature review
    G Damaj
    Hopital Necker Enfants Malades, Paris, France
    Ann Oncol 14:623-9. 2003
    To describe better the clinical, biological, endoscopic and pathological presentations, as well as the outcome, of primary follicular lymphoma (FL) of the gastrointestinal (GI) tract.
  49. ncbi Magnified endoscopic view of primary follicular lymphoma at the duodenal papilla
    Hiroshi Nakase
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University
    Intern Med 46:141-2. 2007
  50. ncbi Vaccination strategies in follicular lymphoma
    Shibichakravarthy Kannan
    Department of Lymphoma and Myeloma, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 903, Houston, TX 77030, USA
    Curr Hematol Malig Rep 4:189-95. 2009
    b>Follicular lymphoma is one of the most immune-responsive cancers...
  51. pmc Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: support for a "vaccinal effect" of rituximab
    Shannon P Hilchey
    James P Wilmot Cancer Center, Aab Institute of Biomedical Sciences, and Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, NY 14642, USA
    Blood 113:3809-12. 2009
    ..rituximab, a chimeric anti-CD20 monoclonal antibody, into the therapeutic armamentarium for patients with follicular lymphoma (FL) has significantly improved treatment outcome for such patients...
  52. ncbi Prognostic factors in follicular lymphoma
    Thomas Relander
    Department of Pathology, British Columbia Cancer Agency and University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Oncol 28:2902-13. 2010
    b>Follicular lymphoma (FL) is one of the most common types of non-Hodgkin's lymphoma. It is usually diagnosed at an advanced stage, for which many treatment options exist, however, no curative standard therapy has been identified...
  53. ncbi Immunochemotherapy with in vivo purging and autotransplant induces long clinical and molecular remission in advanced relapsed and refractory follicular lymphoma
    L Arcaini
    Division of Hematology, Fondazione IRCCS Policlinico S Matteo, University of Pavia, Pavia
    Ann Oncol 19:1331-5. 2008
    To evaluate the clinical outcome of patients with relapsed or refractory follicular lymphoma treated with immunochemotherapy, in vivo purging and high-dose therapy with autotransplant.
  54. ncbi Follicular lymphoma prognostic factors in the modern era: what is clinically meaningful?
    Ph Solal-Céligny
    Centre J Bernard, Service d Hematologie, Le Mans, France
    Int J Hematol 92:246-54. 2010
    ..The Follicular Lymphoma International Prognostic Index (FLIPI) has been designed to separate patients into 3 groups with ..
  55. ncbi Time to treatment response in patients with follicular lymphoma treated with bortezomib is longer compared with other histologic subtypes
    Owen A O'Connor
    NYU Cancer Institute, NYU Langone Medical Center, New York, New York, USA
    Clin Cancer Res 16:719-26. 2010
    ..To determine the antitumor activity of the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin's lymphoma...
  56. ncbi Nodal follicular lymphoma: the role of radiotherapy for stages I and II
    Frank Heinzelmann
    Department of Radiation Oncology, University of Tubingen, Tubingen, Germany
    Strahlenther Onkol 186:191-6. 2010
    To clarify the role of external-beam radiotherapy (RT) in patients with stage I and II nodal follicular lymphoma (FL).
  57. ncbi Expression of activation-induced cytidine deaminase in human B-cell non-Hodgkin lymphomas
    Jobst Greeve
    Zentrum fur Innere Medizin, Medizinische Klinik I, Universitatsklinikum Hamburg Eppendorf, Germany
    Blood 101:3574-80. 2003
    ..In a survey of human B-NHL AID was found to be constitutively expressed in follicular lymphoma and in diffuse large B-cell lymphoma but to be absent in B-precursor lymphoblastic leukemia, in mantle cell ..
  58. ncbi Small intestinal follicular lymphoma with multiple tumor formations diagnosed by double-balloon enteroscopy
    Kazuyoshi Higuchi
    Department of Gastroenterology, Honjo Daiichi General Hospital, Yurihonjo, Akita
    Intern Med 46:705-9. 2007
    b>Follicular lymphoma of the small intestine remains relatively rare, especially in its early stage. Recently, double-balloon endoscopy has enabled observation of the entire small intestine...
  59. ncbi High numbers of tumor-associated macrophages have an adverse prognostic value that can be circumvented by rituximab in patients with follicular lymphoma enrolled onto the GELA-GOELAMS FL-2000 trial
    Danielle Canioni
    Department of Pathology, Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, Universite Paris Descartes, 149 rue de Sevres, 75015, Paris, France
    J Clin Oncol 26:440-6. 2008
    High amounts of intratumoral macrophages have been shown to correlate with poor prognosis in patients with follicular lymphoma (FL) treated with chemotherapy without rituximab...
  60. ncbi Risk and clinical implications of transformation of follicular lymphoma to diffuse large B-cell lymphoma
    Silvia Montoto
    Cancer Research UK Medical Oncology Unit, Barts and The London, Queen Mary s School of Medicine and Dentistry, United Kingdom
    J Clin Oncol 25:2426-33. 2007
    To study the clinical significance of transformation to diffuse large B-cell lymphoma (DLBCL) in patients with follicular lymphoma (FL).
  61. ncbi The impact of follicular lymphoma on health-related quality of life
    R Pettengell
    Haematology and Oncology, St George s Hospital, London, UK
    Ann Oncol 19:570-6. 2008
    The purpose of this study was to determine whether there was a relationship between disease activity and health functioning, as measured by a range of patient-reported outcome (PRO) measures in patients with follicular lymphoma (FL).
  62. ncbi Rituximab maintenance for the treatment of patients with follicular lymphoma: systematic review and meta-analysis of randomized trials
    Liat Vidal
    Institute of Hematology, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel
    J Natl Cancer Inst 101:248-55. 2009
    b>Follicular lymphoma is characterized by slow growth and an initially high rate of response to treatment, but patients typically relapse and experience progressive disease...
  63. pmc Follicular lymphoma B cells induce the conversion of conventional CD4+ T cells to T-regulatory cells
    Weiyun Z Ai
    Department of Medicine, Divisions of Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Int J Cancer 124:239-44. 2009
    ..Some studies have shown that T-cell receptor (TCR) stimulation can convert conventional T cells into Treg. Follicular lymphoma (FL) B cells can enhance this Treg conversion...
  64. pmc DNA hypermethylation accompanied by transcriptional repression in follicular lymphoma
    LYNDA B BENNETT
    Department of Pathology and Anatomical Sciences, University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
    Genes Chromosomes Cancer 48:828-41. 2009
    ..microarray technologies were used to study DNA methylation accompanied by transcriptional changes in follicular lymphoma (FL)...
  65. pmc Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone
    Andrew L Feldman
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892 1500, USA
    Blood 111:5433-9. 2008
    Rare cases of histiocytic and dendritic cell (H/DC) neoplasms have been reported in patients with follicular lymphoma (FL), but the biologic relationship between the 2 neoplasms is unknown...
  66. pmc Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model
    Alan A Arnold
    Department of Internal Medicine, Division of Hematology Oncology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Mol Cancer 7:20. 2008
    ..of anti-apoptotic Bcl-2 family proteins have been linked to a poor survival rate of patients with Follicular Lymphoma (FL)...
  67. pmc Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma
    Jonathan W Friedberg
    James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA
    Br J Haematol 146:282-91. 2009
    ..rituximab (375 mg/m(2) weekly x 4) in patients (n = 23) with relapsed/refractory, histologically confirmed follicular lymphoma, and evaluated immunological changes following the combination...
  68. ncbi Myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission prolongs progression-free survival in follicular lymphoma: results of a prospective, randomized trial of the German Low-Grade Lymphoma Study Group
    Georg Lenz
    Department of Internal Medicine III, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
    Blood 104:2667-74. 2004
    Conventional chemotherapy has failed to substantially prolong survival for patients with advanced follicular lymphoma. To improve outcomes, the German Low-Grade Lymphoma Study Group (GLSG) initiated a randomized trial to compare the ..
  69. ncbi Number of CD4+ cells and location of forkhead box protein P3-positive cells in diagnostic follicular lymphoma tissue microarrays correlates with outcome
    Abigail M Lee
    Cancer Research UK, Medical Oncology Unit, St Bartholomew s Hospital, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Clin Oncol 24:5052-9. 2006
    To examine the immune microenvironment in diagnostic follicular lymphoma (FL) biopsies and evaluate its prognostic significance.
  70. ncbi Frontline therapy with rituximab added to the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) significantly improves the outcome for patients with advanced-stage follicular lymphoma compared with therapy with CHOP alone: r
    Wolfgang Hiddemann
    Department of Internal Medicine III, University of Munich, Grosshadern Marchioninistr 15, 81377 Munchen, Germany
    Blood 106:3725-32. 2005
    Phase 2 studies suggest that the monoclonal antibody rituximab may improve the prognosis of patients with follicular lymphoma (FL) when it is added to chemotherapy...
  71. pmc Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells
    Jonathan M Irish
    Department of Medicine, Oncology Division, Baxter Laboratory for Genetic Pharmacology, Stanford University Medical Center, Stanford, CA 94305 5151, USA
    Blood 108:3135-42. 2006
    ..We used single-cell signaling profiles to compare follicular lymphoma (FL) B cells and nonmalignant host B cells within individual patient biopsies and identified BCR-mediated ..
  72. ncbi Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma
    Davide Rossi
    Division of Hematology, Department of Clinical and Experimental Medicine and IRCAD, Amedeo Avogadro University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy
    Haematologica 91:1405-9. 2006
    The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown...
  73. ncbi Long-term outcome and mortality trends in early-stage, Grade 1-2 follicular lymphoma treated with radiation therapy
    Beverly A Guadagnolo
    Joint Center for Radiation Therapy Harvard Radiation Oncology Residency Program, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 64:928-34. 2006
    To analyze long-term outcomes and causes of death in patients receiving radiation therapy (RT) for localized, low-grade follicular lymphoma.
  74. ncbi Insights into the molecular pathogenesis of follicular lymphoma arising from analysis of geographic variation
    James J Biagi
    Department of Haematology, The Peter MacCallum Cancer Institute, East Melbourne, Vic, Australia
    Blood 99:4265-75. 2002
    Incidence rates of follicular lymphoma (FL) inexplicably vary markedly between Western and Asian countries...
  75. ncbi In situ localization of follicular lymphoma: description and analysis by laser capture microdissection
    Peijie Cong
    Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Blood 99:3376-82. 2002
    ..We propose the designation in situ localization of follicular lymphoma (FL) for this phenomenon...
  76. ncbi Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma
    Wen Kai Weng
    Department of Internal Medicine, Stanford University School of Medicine, CA 94305, USA
    J Clin Oncol 21:3940-7. 2003
    ..Several Fc gamma R polymorphisms have been identified that may affect the killing function of natural killer cells and macrophages...
  77. ncbi High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma
    Joaquim Carreras
    Hematopathology Section, Department of Pathology, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Blood 108:2957-64. 2006
    The tumor microenvironment plays an important role in the biologic behavior of follicular lymphoma (FL), but the specific cell subsets involved in this regulation are unknown...
  78. ncbi CXCL13 (BCA-1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cells
    Herve Husson
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Br J Haematol 119:492-5. 2002
    ..The production of CXCL13 by FL cells and CXCL12 by stromal cells probably directs and participates in the accumulation of FL cells within specific anatomic sites...
  79. ncbi Increased incidence of follicular lymphoma in the duodenum
    T Yoshino
    Department of Pathology, Okayama University Medical School, Japan
    Am J Surg Pathol 24:688-93. 2000
    The incidence of indolent lymphomas in the lymph nodes and extranodal regions is quite different. Follicular lymphoma (FL) is most common in the nodes, and it seems to be least common in the gastrointestinal (GI) tract, where mucosa-..
  80. ncbi Multimodal therapy for localized spinal epidural follicular lymphoma
    Christoph Kahl
    Department of Internal Medicine, Division of Hematology and Oncology, University of Rostock, Germany
    Onkologie 33:381-4. 2010
    ..An epidural growth of low-grade lymphoma is even more unusual. Due to this low incidence, therapeutic experience for this entity is limited...
  81. ncbi Frequency of the Bcl-2/IgH rearrangement in normal individuals: implications for the monitoring of disease in patients with follicular lymphoma
    K E Summers
    Imperial Cancer Research Fund Medical Oncology Unit, St Bartholomew's Hospital Medical College, London, United Kingdom
    J Clin Oncol 19:420-4. 2001
    ..to define the potential complication this may pose for the molecular monitoring of disease in patients with follicular lymphoma (FL)...
  82. ncbi Molecular pathogenesis of follicular lymphoma: a cross talk of genetic and immunologic factors
    Daphne de Jong
    Department of Pathology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Clin Oncol 23:6358-63. 2005
    b>Follicular lymphoma (FL) is the second most frequent type of non-Hodgkin's lymphoma in adults. The disease is characterized by an indolent course with frequent relapses...
  83. pmc Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis
    Sandrine Roulland
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, 13288 Marseille, France
    J Exp Med 203:2425-31. 2006
    b>Follicular lymphoma is one of the most common adult lymphoma, and remains virtually incurable despite its relatively indolent nature...
  84. ncbi PKC zeta mTOR pathway: a new target for rituximab therapy in follicular lymphoma
    Ludivine Leseux
    INSERM, Unite 563, Centre de Physiopathologie de Toulouse Purpan, Universite Toulouse III Paul Sabatier, Toulouse, France
    Blood 111:285-91. 2008
    ..We found that follicular lymphoma cells displayed an increase in PKCzeta expression and activity levels, compared with nonmalignant B cells, ..
  85. ncbi Phase I/II study of galiximab, an anti-CD80 antibody, for relapsed or refractory follicular lymphoma
    Myron S Czuczman
    Roswell Park Cancer Institute, Elm and Carlton St, Buffalo, NY 14263 0001, USA
    J Clin Oncol 23:4390-8. 2005
    This multicenter, dose-escalation study evaluates the safety, pharmacokinetics, and efficacy of galiximab (anti-CD80 monoclonal antibody) in patients with relapsed or refractory follicular lymphoma.
  86. pmc Expression of the follicular lymphoma variant translocation 1 gene in diffuse large B-cell lymphoma correlates with subtype and clinical outcome
    David R Czuchlewski
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA
    Am J Clin Pathol 130:957-62. 2008
    ..Less well studied is the role of the follicular lymphoma variant translocation 1 (FVT1) gene, which was identified through its involvement in an atypical follicular ..
  87. ncbi Bone marrow histological patterns can predict survival of patients with grade 1 or 2 follicular lymphoma: a study from the Groupe d'Etude des Lymphomes Folliculaires
    Danielle Canioni
    Pathology Department, Hopital Necker Enfants Malades, Paris
    Br J Haematol 126:364-71. 2004
    ..These results indicate that BMB histology can predict survival of FL patients with a high tumour burden, and may help in defining their treatment...
  88. ncbi VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia
    Alexander Egle
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Blood 103:2276-83. 2004
    In human follicular lymphoma the t(14; 18) chromosome translocation activates the antiapoptotic oncogene Bcl2 by linking it to the immunoglobulin heavy chain (IGH) locus...
  89. ncbi Follicular lymphoma: time for a re-think?
    Maher K Gandhi
    Department of Haematology, Princess Alexandra Hospital, Brisbane, 4006 QLD, Australia
    Blood Rev 19:165-78. 2005
    b>Follicular lymphoma (FL) is a malignancy of follicle centre B cells that have at least a partially follicular pattern, and is the commonest type of indolent Non-Hodgkin's lymphoma...
  90. ncbi Cytologic differential diagnosis of follicular lymphoma grades 1 and 2 from reactive follicular hyperplasia: cytologic features of fine-needle aspiration smears with Pap stain and fluorescence in situ hybridization analysis to detect t(14;18)(q32;q21) chr
    Koji Kishimoto
    Department of Pathology, Showa University Fujigaoka Hospital, Yokohama, Japan
    Diagn Cytopathol 34:11-7. 2006
    ..Here, we applied Pap stain for cytomorphologic differential diagnosis of follicular lymphoma (FL) from reactive follicular hyperplasia (RFH)...
  91. pmc Follicular lymphoma cells induce T-cell immunologic synapse dysfunction that can be repaired with lenalidomide: implications for the tumor microenvironment and immunotherapy
    Alan G Ramsay
    Institute of Cancer, Cancer Research UK Clinical Centre for Medical Oncology, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom
    Blood 114:4713-20. 2009
    ..Here we identify impaired T-cell immunologic synapse formation as an active immunosuppressive mechanism in follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL)...
  92. ncbi Serum autotaxin measurement in haematological malignancies: a promising marker for follicular lymphoma
    Akiko Masuda
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Br J Haematol 143:60-70. 2008
    ..The serum ATX antigen levels in patients with B-cell neoplasms, especially follicular lymphoma (FL), were higher than those in healthy subjects...
  93. ncbi Anti-idiotypic Immunotherapy in follicular lymphoma patients: results of a long follow-up study
    Rosa Yañez
    Department of Immunology, Hospital Clinica Puerta de Hierro, Madrid, Spain
    J Immunother 31:310-2. 2008
    ..We analyze the clinical outcome and the presence of tumor cells in the blood of 8 patients with follicular lymphoma, vaccinated with autologous idiotype protein from their lymphoma cells...
  94. ncbi Treatment of follicular lymphoma: current status
    Herve Tilly
    Centre Henri Becquerel, Rouen, France
    Leuk Lymphoma 49:7-17. 2008
    With the recent proliferation of treatment options for patients with follicular lymphoma (FL), median survival has been shown to have improved, from 84 months between 1983 and 1989 to 93 months between 1993 and 1999...
  95. ncbi High-dose therapy and autologous hematopoietic-cell transplantation for follicular lymphoma beyond first remission: the Stanford University experience
    T M Cao
    Department of Medicine, Division of Bone Marrow Transplantation, Stanford University Medical Center, California 94305-5623, USA
    Biol Blood Marrow Transplant 7:294-301. 2001
    ..or relapsed follicular low-grade lymphoma (FLGL), follicular large cell lymphoma (FLCL), and transformed follicular lymphoma (TFL) were treated with myeloablative therapy consisting of etoposide (60 mg/kg), cyclophosphamide (100 mg/..
  96. ncbi Overexpression of SOCS3 is associated with decreased survival in a cohort of patients with de novo follicular lymphoma
    Ravitharan Krishnadasan
    Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Br J Haematol 135:72-5. 2006
    ..001, log rank test). After adjusting for Follicular Lymphoma International Prognostic Index subgroups, SOCS3 overexpression remained an independent predictor of ..
  97. ncbi Follicular lymphoma of the pancreas: a case report and proposed new strategies for diagnosis and surgery of benign or low-grade malignant lesions of the head of the pancreas
    Naohiro Sata
    Department of Surgery, Jichi Medical University, Tochigi, Japan
    JOP 8:44-9. 2007
    Primary pancreatic lymphoma is a rare form of extranodal lymphoma originating in the pancreas. The present report describes a case of follicular lymphoma of the pancreas with unique CT and MRI findings.
  98. ncbi Stage I/II follicular lymphoma: spread of bcl-2/IgH+ cells in blood and bone marrow from primary site of disease and possibility of clearance after involved field radiotherapy
    Alessandro Pulsoni
    Division of Haematology, Dipartimento di Biotecnologie Cellulari ed Ematologia, La Sapienza University, Rome, Italy
    Br J Haematol 137:216-20. 2007
    Stage I/IIA follicular lymphoma (FL) is considered a localised disease that can be adequately treated with radiotherapy alone...
  99. ncbi Intracytoplasmic immunoglobulin crystals in follicular lymphoma
    Ryuichi Wada
    Department of Pathology, Hirosaki University School of Medicine, Hirosaki, Japan
    Hum Pathol 33:1141-4. 2002
    We report a case of follicular lymphoma with crystal inclusions...
  100. ncbi Quantitative PCR analysis for Bcl-2/IgH in a phase III study of Yttrium-90 Ibritumomab Tiuxetan as consolidation of first remission in patients with follicular lymphoma
    Lindsey Goff
    Cancer Research UK Medical Oncology Unit, St Bartholomew s Hospital, 45 Little Britain, London EC1A 7BE, United Kingdom
    J Clin Oncol 27:6094-100. 2009
    PURPOSE The randomized First-Line Indolent Trial (FIT) was conducted in patients with advanced follicular lymphoma (FL), to evaluate the safety and efficacy of yttrium-90 ((90)Y) ibritumomab tiuxetan given as consolidation of complete or ..
  101. ncbi Cellular pharmacology of P-ethoxy antisense oligonucleotides targeted to Bcl-2 in a follicular lymphoma cell line
    Yolanda Gutierrez-Puente
    Immunobiology and Drug Carriers Section, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Leuk Lymphoma 44:1979-85. 2003
    ..inhibited Bcl-2 protein expression and induced growth inhibition in t(14;18)-positive transformed follicular lymphoma (FL) cell lines...

Research Grants62

  1. GB Virus C and Non-Hodgkins Lymphoma Risk and Prognosis
    Jack T Stapleton; Fiscal Year: 2013
    ..the association of GBV-C with NHL subtypes (diffuse large B cell lymphoma, other B-cell lymphomas, follicular lymphoma, or T cell lymphomas) will be examined, although power to assess subtype-specific associations was limited...
  2. Cell Death Regulation by Pro-Apoptotic BOK During Hematopoiesis
    Samuel G Katz; Fiscal Year: 2013
    ..g. thrombocytopenia) or pathologic cellular survival as seen in hematologic cancers (e.g. follicular lymphoma)...
  3. Vitamin D and Non-Hodgkin Lymphoma Prognosis
    Jennifer L Kelly; Fiscal Year: 2012
    ..the role of vitamin D in lymphoma prognosis, with a focus on the two most common NHL subtypes, DLBCL and follicular lymphoma (FL)...
  4. Molecular epidemiology of non-Hodgkin lymphoma prognosis and prevention
    Sophia Wang; Fiscal Year: 2013
    ..survival, with a focus on the two most common NHL subtypes, diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma. Our study is among only a handful with NHL cases treated in the immunotherapy (rituximab) era (post-2000), ..
  5. 1H NMR STUDIES OF NON-HODGKINS LYMPHOMA
    Jerry D Glickson; Fiscal Year: 2012
    ..regional response of the tumor, and 3) to extend the study to more responsive DLBCL xenograft models and to follicular lymphoma, the next most common form of NHL...
  6. CD20-targeted IL-15 immunotherapeutic for B-cell malignancies
    Hing C Wong; Fiscal Year: 2012
    ..provides patients with B-cell malignancies with significant clinical benefit, indolent lymphomas, such as follicular lymphoma and chronic lymphocytic leukemia (CLL), remain incurable with patients exhibiting relapses and refractory ..
  7. Targeting B-cell lymphoma with Leukothera
    Benjamin A Belinka; Fiscal Year: 2013
    ..mantle cell lymphoma (MCL), follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), and Burkitt lymphoma)...
  8. Predictors of clinical outcome after therapeutic vaccination in follicular lympho
    Sattva S Neelapu; Fiscal Year: 2013
    ..colony stimulating factor, GM-CSF) to patients with advanced stage, previously untreated follicular lymphoma (FL), in complete remission following standard induction chemotherapy...
  9. Genetic Modifiers of the Anti-apoptotic Functions of Bcl-2
    CICELY ANNE JETTE; Fiscal Year: 2010
    ..The long-term goal of this application is to restore normal cell death pathways in B-cell follicular lymphoma and other hematological cancers by targeting pivotal molecules with small molecule inhibitors or antibodies...
  10. Resequencing and Functional Studies to Identify Causal Gene Variants of Lymphoma
    Christine F Skibola; Fiscal Year: 2013
    ..32-33 in the major histocompatibility complex (MHC) region were associated with risk of follicular lymphoma (FL), one of the major subtypes of NHL. Our GWAS suggests an important genetic role exists for FL...
  11. Systems Biology of Tumor Progression and Drug-Resistance
    Andrea Califano; Fiscal Year: 2010
    ..for which we have developed detailed computational and experimental models, including (a) Progression from Follicular Lymphoma (FL) to Diffuse Large B Cell Lymphoma (DLBCL) (b) Glucocorticoid resistance in T-lineage Acute ..
  12. Molecular Targeting of Diffuse Large B-cell Lymphoma
    Ari M Melnick; Fiscal Year: 2013
    ..of patients with two most frequent forms of lymphoma: the diffuse large B-cell lymphomas (DLBCL) and follicular lymphoma (FL)...
  13. Detection of Light Chain Restriction in non-Hodgkin Lymphoma by a Novel RNA In Si
    Xiao Jun Ma; Fiscal Year: 2012
    ..sensitivity to detect LCR in many non-Hodgkin lymphoma (NHL), including the most common NHL variants - follicular lymphoma, diffuse large B cell lymphoma, small B lymphocytic lymphoma, and extranodal marginal zone lymphoma of MALT ..
  14. Rituximab Elicitation of Tumor Specific T-cell Responses in Lymphoma Patients
    Steven H Bernstein; Fiscal Year: 2012
    ..monoclonal antibody directed against CD20, has shown significant therapeutic activity in patients with follicular lymphoma (FL), yet it's exact mechanism of action has not been completely defined...
  15. Cooperation of PTEN and SHIP as tumor suppressors in B-Cells
    Irene Munk Pedersen; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): B-cell cancers such as CLL (Chronic Lymphocytic Leukemia), FL (Follicular Lymphoma) and DLBCL (Diffuse Large B-cell Lymphoma) account for the majority of hematological malignancies in the Western ..
  16. Role of MLL2 Gene Inactivation in B cell Non Hodgkin Lymphoma
    Laura Pasqualucci; Fiscal Year: 2013
    ..NHL), accounting for 30-40% of the de-novo diagnoses and also arising as a frequent clinical evolution of follicular lymphoma (FL)...
  17. Identification of biomarkers of fatty acid intake
    Hannia Campos; Fiscal Year: 2002
    ..T cell clones expressing a CD20-specific scFvFc:zeta chimeric immunoreceptor into patients with relapsed follicular lymphoma in a small Phase I pilot trial...
  18. Computer-assisted Grading and Risk Stratification of Follicular Lymphoma
    METIN NAFI GURCAN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Follicular lymphoma (FL) is the second most common non-Hodgkin's lymphoma. Several treatment options exist today, but these are costly and include significant toxicities...
  19. Genetic Basis of Signaling Heterogeneity in Human Follicular Lymphoma
    Ronald Levy; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Follicular lymphoma (FL) is generally an incurable disease. In each case the tumor is composed of a clonal population of B cells with a unique B cell antigen receptor (BCR)...
  20. ACTIVATION OF BCL-2 IN HEMATOLOGIC MALIGNANCIES
    Linda M Boxer; Fiscal Year: 2012
    Project Summary Follicular lymphoma is characterized by the t(14;18) translocation, which links the bcl-2 gene with the immunoglobulin heavy chain gene (IgH)...
  21. Computational Modeling of Cancer Biology
    Sylvia Plevritis; Fiscal Year: 2009
    ..Our study in humans will focus on the transformation of follicular lymphoma to high grade lymphoma using gene expression data derived from tissue that is correlated to clinical events ..
  22. Disruption of HLA Class II-Mediated Immune Recognition of B-Cell Lymphomas
    Azizul Haque; Fiscal Year: 2013
    ..class II-restricted CD4+ cytotoxic T cells (CTL) could be generated against BL and as well as non-Hodgkins follicular lymphoma (FL)...
  23. Small Molecule Inhibitors of the BCL6 Oncoprotein
    Arie Zask; Fiscal Year: 2013
    ..of patients with the two most frequent forms of lymphoma: the diffuse large B-cell lymphomas (DLBCL) and follicular lymphoma (FL)...
  24. Role of acetyltransferase gene inactivation in follicular lymphoma pathogenesis
    Riccardo Dalla-Favera; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Follicular Lymphoma (FL) represents the second most common form of B-cell non-Hodgkin Lymphoma (B-NHL), accounting for ~30% of the de-novo diagnoses (Swerdlow et al., 2008)...
  25. Modeling the Role of Differentiation in Cancer Progression
    SYLVIA KATINA PLEVRITIS; Fiscal Year: 2013
    ..These computational approaches will be applied to the study of differentiation in AML, Follicular Lymphoma and T-ALL. In AML, we will identify regulatory networks driving leukemic stem cells...
  26. The BCL-2 Homologues of Gamma Herpesviruses
    J Marie Hardwick; Fiscal Year: 2006
    ..The human Bcl-2 gene was first identified at the characteristic translocation breakpoints in follicular lymphoma leading to overexpression of BCL-2 protein...
  27. OLIGONUCLEOTIDE INHIBITION OF CELL PROLIFERATION
    Eric Wickstrom; Fiscal Year: 2000
    ..clinical trials of oligonucleotide therapeutics have demonstrated antisense efficacy in patients against follicular lymphoma, chronic myelogenous leukemia, cytomegalovirus and Crohn's disease...
  28. TUMOR HOST RELATIONSHIPS IN HUMAN LYMPHOMAS IN VIVO
    Roger Warnke; Fiscal Year: 1993
    ..Studies of sequential biopsies from follicular lymphoma patients may provide insights in tumor progression/transformation...
  29. FUNCTION OF THE BCL-2 PROTEIN
    DONALD EWERT; Fiscal Year: 1993
    ..About 90% of follicular lymphoma of B-cell origin, one of the most common hematopoietic malignancies, carry a specific chromosomal ..
  30. CD19-Specific T-Cell Therapy for Follicular Lymphoma
    LAURENCE COOPER; Fiscal Year: 2004
    Currently, patients with treatment-refractory follicular lymphoma, the most common sub-type of non-Hodgkin's lymphoma, have a poor chance of disease-free survival and this group needs to be treated with innovative approaches...
  31. BC1-2 REARRANGEMENTS IN CLL
    Louise Showe; Fiscal Year: 1992
    ..b>Follicular lymphoma is one of the most common hematopoietic tumors in the United States and has been shown to carry a specific ..
  32. MOLECULAR STUDIES ON THE EVOLUTION OF B-CELL LYMPHOMAS
    CHARLOTTE GAUWERKY; Fiscal Year: 1991
    ..The t(14;18) translocation is found in follicular lymphoma, the t(11;14) translocation in diffuse small and large cell lymphoma, and the t(8;14), t(2;8) or t(8;22) ..
  33. THERAPEUTIC DNA VACCINES TO TREAT B CELL LYMPHOMA
    Peter Hobart; Fiscal Year: 2000
    ..to increase potency of a plasmid DNA tumor vaccine being developed for the treatment of low grade non-follicular lymphoma. Based on the results of pre-clinical tumor challenge studies in a mouse lymphoma model system and a Phase ..
  34. Stromal Cell Molecules Required for Lymphoma Generation
    Li Li; Fiscal Year: 2006
    In the early stage, follicular lymphoma, one of the most common hematological malignancies in adults, is usually indolent, regressing spontaneously and showing susceptibility to chemotherapy...
  35. MINIMAL RESIDUAL DISEASE IN LYMPHOMAS WITH THE T-14-18
    Ming Sheng Lee; Fiscal Year: 1993
    ..A retrospective study also will be performed in a highly selected group of patients with follicular lymphoma who have been in continuous remission for more than two year even though the structure of the bcl-2 gene in ..
  36. EXPRESSION PROFILING OF PROGRESSED FOLLICULAR LYMPHOMAS
    Kojo Elenitoba Johnson; Fiscal Year: 2001
    ..t(14;18) translocation in both samples in order to ensure that both neoplasms originate from a follicular lymphoma. The microarray technology permits the simultaneous study of the expression status of multiple genes and ..
  37. Prediagnostic Markers of Immune Activation and Viral Infection and Risk of NHL
    Otoniel Martinez Maza; Fiscal Year: 2009
    ..are associated with the subsequent development of B cell NHL (diffuse large B cell lymphoma [DLBCL] and follicular lymphoma) in apparently immunocompetent individuals;2) determine whether altered patterns of antibodies to EBV, ..
  38. Activation of BCL-2 in Hematologic Malgnancies
    LINDA BOXER; Fiscal Year: 2007
    b>Follicular lymphoma is characterized by the t(14;18) translocation, which links the bcl-2 gene with the immunoglobulin heavy chain gene (IgH). The translocated bcl-2 allele is expressed at high levels, and the normal allele is silent...
  39. GENES ACTIVATED IN TRANSFORMATION OF FOLLICULAR LYMPHOMA
    Andrew Zelenetz; Fiscal Year: 1990
    ..Unfortunately, the follicular lymphoma tissue cannot be grown in vitro, thus mRNA from the follicular lymphomas is limited...
  40. MECHANISM & REGULATION OF BCL-2 ANTIPROLIFERATIVE EFFECT
    ZOLTAN OLTVAI; Fiscal Year: 2001
    ..may contribute to the secondary malignant transformations of Bcl-2 expressing indolent tumors, such as follicular lymphoma. Their proposed research program aims to examine the relation of Bcl-2's phosphorylation to its ..
  41. Molecular Epidemiology of non-Hodgkin Lymphoma Survival
    James R Cerhan; Fiscal Year: 2010
    ..host (inherited) immune genes and DNA repair genes that individually and in aggregate predict survival for follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) beyond classic clinical and demographic prognostic factors...
  42. Immunogenetics of Non-Hodgkin Lymphoma Survival
    James Cerhan; Fiscal Year: 2006
    ..abstract_text> ..
  43. A Genome-Wide Association Study of Non-Hodgkin Lymphoma
    Christine F Skibola; Fiscal Year: 2010
    ..The data generated from this study will provide a framework for further investigation within the NHL consortium, InterLymph. Results will later be combined with that from other InterLymph case-control studies in pooled analyses. ..
  44. Monoclonal Antibody Therapy for Follicular Lymphoma
    Jonathan Friedberg; Fiscal Year: 2007
    ..abstract_text> ..
  45. BLys inhibition using TACI-Fc in patients with B-bell non-Hodgkins' Lymphoma
    Stephen Ansell; Fiscal Year: 2008
    ..abstract_text> ..
  46. Novel Monoclonal Antibody Therapies for Lymphoma
    John Leonard; Fiscal Year: 2005
    ..It is also expected that this work will significantly contribute to the care of patients with these and other B-cell malignancies. ..
  47. Prognostic Models in Diffuse Large B-Cell Lymphoma
    Izidore S Lossos; Fiscal Year: 2010
    ..Further, establishment of a paraffin-based RNA prognostic model using the new methodology of RNA extraction could serve as a paradigm for other lymphomas and tumors. ..
  48. ANTI-CD20 ANTIBODY THERAPY OF NHL-- MECHANISM OF ACTION
    David Maloney; Fiscal Year: 2002
    ..III. Determine the role of the mAb FC region in mediating anti- proliferative effects of anti-CD20 mAbs in xenografts of B cell NHL lines in NOD/SCID mice. ..
  49. INTEGRIN SIGNALING IN ACUTE LYMPHOBLASTIC LEUKEMIA
    Arnold Freedman; Fiscal Year: 2001
    ..Understanding the cell-cell interaction between BM stromal cells and pre-B ALL cells may provide future therapeutic strategies with which to modulate the growth of these leukemias. ..
  50. CpG Plus Rituximab Therapy in Follicular Lymphoma
    Arnold Freedman; Fiscal Year: 2005
    ..This study is a novel approach to treating FL, where augmenting antigen presentation and effector cells may lead to enhanced cytotoxic effects of rituximab and induce anti-tumor immunity. ..
  51. Etanercept Therapy in Follicular Lymphoma
    Arnold Freedman; Fiscal Year: 2003
    ..This study is a novel approach to treating FL, where targeting the microenvironment of the tumor may inhibit the growth and survival of the neoplastic cells. ..
  52. Mechanism of Antibody Therapy in Human B Cell Lymphoma
    Wen Kai Weng; Fiscal Year: 2007
    ..The knowledge generated from this project will help us to design better ways to use monoclonal antibodies and to develop new reagents to treat patients with B cell lymphoma. [unreadable] [unreadable]..
  53. Inducing and targeting of EBV lytic antigens in lymphoma
    Sven de Vos; Fiscal Year: 2006
    ..We anticipate a successful clinical trial and plan the extension to a larger multi center clinical trial in the time following the K23 granting period. ..
  54. Characterization of Methods for Preservation of Phosphoproteins in fixed tissues
    Eric Hsi; Fiscal Year: 2007
    ..Furthermore, control material with defined relative expression levels of many PPs will result from this application and allow laboratories to assess performance of their individual assays. [unreadable] [unreadable] [unreadable]..
  55. Quantitative RT-PCR: Prediction Lymphoma Transformation
    Kojo Elenitoba Johnson; Fiscal Year: 2005
    ..foundation for the gene expression profiling studies evaluating the predictive power of a previously identified set of ~30 genes to predict the transformation of follicular lymphoma to an aggressive large B-cell lymphoma in phase II.
  56. TECHNIQUES FOR CALCULATING TUMOR DOSIMETRY FROM IMAGING
    KENNETH KORAL; Fiscal Year: 2003
    ..Applications of the methods to other therapies and to imaging with other multi-gamma-emission radionuclides such as 111-In are also possible. ..
  57. Inflammatory Markers in a 2-Year Soy Intervention among Premenopausal Women
    Gertraud Maskarinec; Fiscal Year: 2008
    ..The statistical analysis will apply general linear models to compare the levels of inflammatory markers by soy intake, while taking into account the repeated measurement design. [unreadable] [unreadable] [unreadable] [unreadable]..
  58. Minor Histocompatilibity Vaccination After Allo-Transpl*
    Koen Van Besien; Fiscal Year: 2004
    ..Blood, marrow and skin biopsy samples will be obtained for correlative studies relating to immune reconstitution and minimal residual disease and compared with historical controls. ..
  59. Quality of Life of Testicular Cancer Survivors
    Yawei Zhang; Fiscal Year: 2008
    ..The increasing incidence of TC in young men, and the high survival rate, makes understanding the morbidity associated with TC survival a public health priority. [unreadable] [unreadable] [unreadable]..
  60. INTRACELLULAR TRAFFICKING OF IMMUNOTOXINS
    Oliver Press; Fiscal Year: 2003
    ....