lymphoma

Summary

Summary: A general term for various neoplastic diseases of the lymphoid tissue.

Top Publications

  1. ncbi A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
    G Ambrosini
    Boyer Center for Molecular Medicine, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nat Med 3:917-21. 1997
  2. ncbi The anaplastic lymphoma kinase in the pathogenesis of cancer
    Roberto Chiarle
    Center for Experimental Research and Medical Studies CERMS, University of Torino, Via Santena 7, 10126, Italy
    Nat Rev Cancer 8:11-23. 2008
  3. pmc CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients
    Barbara Savoldo
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA
    J Clin Invest 121:1822-6. 2011
  4. doi A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
    Sarah K Knutson
    Epizyme, Inc, Cambridge, MA, USA
    Nat Chem Biol 8:890-6. 2012
  5. pmc Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001
    Lindsay M Morton
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 7055, Rockville, MD 20852, USA
    Blood 107:265-76. 2006
  6. doi Molecular pathogenesis of T-cell leukaemia and lymphoma
    Iannis Aifantis
    Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Nat Rev Immunol 8:380-90. 2008
  7. ncbi Atm-deficient mice: a paradigm of ataxia telangiectasia
    C Barlow
    Laboratory of Genetic Disease Research, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 86:159-71. 1996
  8. pmc Antitumor activity of silver nanoparticles in Dalton's lymphoma ascites tumor model
    Muthu Irulappan Sriram
    Department of Biotechnology, Division of Molecular and Cellular Biology, Kalasalingam University, Tamilnadu, India
    Int J Nanomedicine 5:753-62. 2010
  9. ncbi Molecular imaging of proliferation in malignant lymphoma
    Andreas K Buck
    Department of Nuclear Medicine, Institute of Pathology, University Hospital Ulm, Ulm, Germany
    Cancer Res 66:11055-61. 2006
  10. ncbi Use of positron emission tomography for response assessment of lymphoma: consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma
    Malik E Juweid
    Department of Radiology, University of Iowa, Iowa City, IA 52242, USA
    J Clin Oncol 25:571-8. 2007

Research Grants

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
  3. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2010
  4. THE AGRICULTURAL HEALTH STUDY - FIELD STATIONS
    Charles Lynch; Fiscal Year: 2010
  5. MERVYN N WEITZMANN; Fiscal Year: 2016
  6. Craig T Morita; Fiscal Year: 2016
  7. GENETIC ANALYSIS OF POLARITY
    RUTH M STEWARD; Fiscal Year: 2010
  8. Rac GTPase signaling during embryonic salivary gland branching morphogenesis
    Sharon Sequeira; Fiscal Year: 2012
  9. Inhibition of IkK to treat lethal Graft-vs.-Host Disease
    Patrick Flood; Fiscal Year: 2009
  10. Cornelia M Weyand; Fiscal Year: 2016

Detail Information

Publications471 found, 100 shown here

  1. ncbi A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
    G Ambrosini
    Boyer Center for Molecular Medicine, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nat Med 3:917-21. 1997
    ..These findings suggest that apoptosis inhibition may be a general feature of neoplasia and identify survivin as a potential new target for apoptosis-based therapy in cancer and lymphoma.
  2. ncbi The anaplastic lymphoma kinase in the pathogenesis of cancer
    Roberto Chiarle
    Center for Experimental Research and Medical Studies CERMS, University of Torino, Via Santena 7, 10126, Italy
    Nat Rev Cancer 8:11-23. 2008
    ..The anaplastic lymphoma kinase (ALK) is the oncogene of most anaplastic large cell lymphomas (ALCL), driving transformation through many ..
  3. pmc CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients
    Barbara Savoldo
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA
    J Clin Invest 121:1822-6. 2011
    ....
  4. doi A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
    Sarah K Knutson
    Epizyme, Inc, Cambridge, MA, USA
    Nat Chem Biol 8:890-6. 2012
    ..Point mutations of EZH2 at Tyr641 and Ala677 occur in subpopulations of non-Hodgkin's lymphoma, where they drive H3K27 hypertrimethylation...
  5. pmc Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001
    Lindsay M Morton
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 7055, Rockville, MD 20852, USA
    Blood 107:265-76. 2006
    ..and End Results (SEER) registries according to the internationally recognized World Health Organization (WHO) lymphoma classification introduced in 2001...
  6. doi Molecular pathogenesis of T-cell leukaemia and lymphoma
    Iannis Aifantis
    Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Nat Rev Immunol 8:380-90. 2008
    ..Finally, we discuss potential new therapies that target oncogenic pathways in T-ALL...
  7. ncbi Atm-deficient mice: a paradigm of ataxia telangiectasia
    C Barlow
    Laboratory of Genetic Disease Research, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 86:159-71. 1996
    ..Atm-disrupted mice recapitulate the ataxia telangiectasia phenotype in humans, providing a mammalian model in which to study the pathophysiology of this pleiotropic disorder...
  8. pmc Antitumor activity of silver nanoparticles in Dalton's lymphoma ascites tumor model
    Muthu Irulappan Sriram
    Department of Biotechnology, Division of Molecular and Cellular Biology, Kalasalingam University, Tamilnadu, India
    Int J Nanomedicine 5:753-62. 2010
    ..the efficacy of biologically synthesized silver nanoparticles (AgNPs) as an antitumor agent using Dalton's lymphoma ascites (DLA) cell lines in vitro and in vivo...
  9. ncbi Molecular imaging of proliferation in malignant lymphoma
    Andreas K Buck
    Department of Nuclear Medicine, Institute of Pathology, University Hospital Ulm, Ulm, Germany
    Cancer Res 66:11055-61. 2006
    ..with the thymidine analogue 3'-deoxy-3'-[(18)F]fluorothymidine (FLT) to detect manifestation sites of malignant lymphoma, to assess proliferative activity, and to differentiate aggressive from indolent tumors...
  10. ncbi Use of positron emission tomography for response assessment of lymphoma: consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma
    Malik E Juweid
    Department of Radiology, University of Iowa, Iowa City, IA 52242, USA
    J Clin Oncol 25:571-8. 2007
    To develop guidelines for performing and interpreting positron emission tomography (PET) imaging for treatment assessment in patients with lymphoma both in clinical practice and in clinical trials.
  11. ncbi Characterization of EBV-genome negative "null" and "T" cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non-Hodgkin lymphoma
    U Schneider
    Int J Cancer 19:621-6. 1977
    ..and cerebral fluid of children with acute lymphoblastic leukemia (ALL) and leukemic transformed non-Hodgkin lymphoma (NHL) were cultivated for at least 8 weeks...
  12. ncbi Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Nature 348:331-3. 1990
    ..In contrast, an analogous myc transgene, designed to mimic the myc-Igh translocation product typical of Burkitt's lymphoma and rodent plasmacytoma, promotes B lymphoid cell proliferation and predisposes mice to malignancy in pre-B and B ..
  13. pmc Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer
    Catherine M Bollard
    Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children s Hospital, Houston, TX 77030, USA
    Blood 110:2838-45. 2007
    ..This study is registered at http://www.cancer.gov/clinicaltrials (protocol IDs: BCM-H-9936, NCT00062868, NCT00070226)...
  14. pmc Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development
    Verena Labi
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria
    J Exp Med 205:641-55. 2008
    ..Finally, Bmf-deficiency accelerated the development of gamma irradiation-induced thymic lymphomas. Our results demonstrate that Bmf plays a critical role in apoptosis signaling and can function as a tumor suppressor...
  15. doi Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project
    Milena Sant
    Department of Preventive and Predictive Medicine, Unit of Analytical Epidemiology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Blood 116:3724-34. 2010
    ..55 for MMs. The commonest LMs were plasma cell neoplasms (4.62), small B-cell lymphocytic lymphoma/chronic lymphatic leukemia (3.79), diffuse B-cell lymphoma (3.13), and Hodgkin lymphoma (2.41)...
  16. ncbi Reverse engineering of regulatory networks in human B cells
    Katia Basso
    Institute for Cancer Genetics, 1300 St Nicholas Avenue, Room 912, New York, New York 10032, USA
    Nat Genet 37:382-90. 2005
    ..The newly identified MYC targets include some major hubs. This approach can be generally useful for the analysis of normal and pathologic networks in mammalian cells...
  17. pmc Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19
    James N Kochenderfer
    Surgery Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Blood 116:4099-102. 2010
    ..We treated a patient with advanced follicular lymphoma by administering a preparative chemotherapy regimen followed by autologous T cells genetically engineered to ..
  18. ncbi Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications
    Philipp J Jost
    III Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Blood 109:2700-7. 2007
    ..lymphocyte proliferation and survival and has recently been recognized as a critical pathogenetic factor in lymphoma. Various molecular events lead to deregulation of NF-kappaB signaling in Hodgkin disease and a variety of T- and ..
  19. pmc Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model
    Marie Eve Bordeleau
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Clin Invest 118:2651-60. 2008
    ..One member of this class of compounds, silvestrol, was able to enhance chemosensitivity in a mouse lymphoma model in which carcinogenesis is driven by phosphatase and tensin homolog (PTEN) inactivation or elevated eIF4E ..
  20. ncbi Live attenuated measles virus induces regression of human lymphoma xenografts in immunodeficient mice
    D Grote
    Molecular Medicine Program, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA
    Blood 97:3746-54. 2001
    ..cytoreductive potential of MV-Ed has been investigated in murine models of both aggressive and indolent B-cell lymphoma in severe combined immunodeficient (SCID) mice...
  21. ncbi Psychological adjustment and sleep quality in a randomized trial of the effects of a Tibetan yoga intervention in patients with lymphoma
    Lorenzo Cohen
    Department of Behavioral Science, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 100:2253-60. 2004
    ..The authors examined the effects of the Tibetan yoga (TY) practices of Tsa lung and Trul khor, which incorporate controlled breathing and visualization, mindfulness techniques, and low-impact postures in patients with lymphoma.
  22. pmc SATB1 defines the developmental context for gene silencing by Xist in lymphoma and embryonic cells
    Ruben Agrelo
    Research Institute of Molecular Pathology, Vienna, Austria
    Dev Cell 16:507-16. 2009
    ..Here, we show that Xist can initiate silencing in a lymphoma model. We identify the special AT-rich binding protein SATB1 as an essential silencing factor...
  23. ncbi Histone deacetylase inhibitors in the treatment of lymphoma
    Manuela Lemoine
    Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Discov Med 10:462-70. 2010
    ..have been approved by the US Food and Drug Administration for treating relapsed cutaneous T-cell lymphoma. Other HDAC inhibitors, such as belinostat (PXD101), mocetinostat (MGCD0103), entinostat (SNDX-275), and ..
  24. pmc Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation
    Verena Labi
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck 6020, Austria
    Genes Dev 24:1602-7. 2010
    ..animals, repeated irradiation injury-induced expansion of hematopoietic stem/progenitor cells (HSCs) leads to lymphoma formation...
  25. doi Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia
    Yasuo Yamanaka
    Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan
    Blood 114:3265-75. 2009
    The gene(s) responsible for natural killer (NK)-cell lymphoma/leukemia have not been identified...
  26. doi Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma
    Björn Lamprecht
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Nat Med 16:571-9, 1p following 579. 2010
    ..We show that B cell-derived Hodgkin's lymphoma cells depend on the activity of the non-B, myeloid-specific proto-oncogene colony-stimulating factor 1 receptor (..
  27. pmc mTORC1 promotes survival through translational control of Mcl-1
    John R Mills
    Department of Biochemistry, McGill University, Montreal, QC, Canada H3G 1Y6
    Proc Natl Acad Sci U S A 105:10853-8. 2008
    ..Here, we demonstrate that loss of TSC2 in the E mu-myc murine lymphoma model leads to mTORC1 activation and accelerated oncogenesis caused by a defective apoptotic program despite ..
  28. ncbi The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
    J M Adams
    Nature 318:533-8. 1985
    ..bearing the cellular myc oncogene coupled to the immunoglobulin mu or kappa enhancer frequently develop a fatal lymphoma within a few months of birth...
  29. ncbi Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma
    Tim A Ahles
    Department of Psychiatry and Center for Psycho Oncology Research, New Hampshire Hospital, Concord, NH, USA
    J Clin Oncol 20:485-93. 2002
    The primary purpose of this study was to compare the neuropsychologic functioning of long-term survivors of breast cancer and lymphoma who had been treated with standard-dose systemic chemotherapy or local therapy only.
  30. pmc Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction
    Miriam Erlacher
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    J Exp Med 203:2939-51. 2006
    The physiological role of B cell lymphoma 2 (Bcl-2) homology 3-only proteins has been investigated in mice lacking the individual genes identifying rate-limiting roles for Bim (Bcl-2-interacting mediator of cell death) and Puma (p53-up-..
  31. ncbi Phase I and pharmacokinetic study of MS-275, a histone deacetylase inhibitor, in patients with advanced and refractory solid tumors or lymphoma
    Qin C Ryan
    Clinical Trials Unit, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, USA
    J Clin Oncol 23:3912-22. 2005
    ..The objective of this study was to define the maximum-tolerated dose (MTD), the recommended phase II dose, the dose-limiting toxicity, and determine the pharmacokinetic (PK) and pharmacodynamic profiles of MS-275...
  32. doi Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
    Ultan McDermott
    Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA
    Cancer Res 68:3389-95. 2008
    ..of 602 cell lines derived from a variety of human cancers, we found that a selective inhibitor of the anaplastic lymphoma kinase (ALK) potently suppressed growth of a small subset of tumor cells...
  33. pmc Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice
    Vera L Tarakanova
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Virol 79:14668-79. 2005
    ..GammaHV68 infection induced two lymphoproliferative lesions: B-cell lymphoma and atypical lymphoid hyperplasia (ALH)...
  34. pmc CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results
    Brian G Till
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 119:3940-50. 2012
    Cellular immune responses have the potential to elicit dramatic and sustained clinical remissions in lymphoma patients...
  35. pmc Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma
    Imran A Babar
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 109:E1695-704. 2012
    ..In this work we show that overexpression of miR-155 in lymphoid tissues results in disseminated lymphoma characterized by a clonal, transplantable pre-B-cell population of neoplastic lymphocytes...
  36. pmc BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma
    Markus Krumbholz
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
    J Exp Med 201:195-200. 2005
    ..This paper identifies astrocytes as a nonimmune source of BAFF. CNS-produced BAFF may support B cell survival in inflammatory diseases and primary B cell lymphoma.
  37. pmc Increased manganese superoxide dismutase expression or treatment with manganese porphyrin potentiates dexamethasone-induced apoptosis in lymphoma cells
    Melba C Jaramillo
    Department of Pathology, University of Arizona, Tucson, Arizona 85724, USA
    Cancer Res 69:5450-7. 2009
    ..Previously, using WEHI7.2 murine thymic lymphoma cells, we found that increasing the resistance to hydrogen peroxide (H(2)O(2)) by catalase transfection or ..
  38. doi Response evaluation criteria for peripheral nodal lymphoma in dogs (v1.0)--a Veterinary Cooperative Oncology Group (VCOG) consensus document
    D M Vail
    The School of Veterinary Medicine and The Carbone Comprehensive Cancer Center, University of Wisconsin Madison, Madison, WI 53706, USA
    Vet Comp Oncol 8:28-37. 2010
    Standardized assessment of response to therapy for lymphoma in dogs is lacking, making critical comparisons of treatment protocols difficult...
  39. doi Genomic profiling combined with gene expression profiling in primary central nervous system lymphoma
    Chang Ohk Sung
    Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Seoul, South Korea
    Blood 117:1291-300. 2011
    Of the genetic changes in primary central nervous system lymphoma (PCNSL), little is known...
  40. doi Does adding FDG-PET to MRI improve the differentiation between primary cerebral lymphoma and glioblastoma? Observer performance study
    Keishi Makino
    Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Japan
    Ann Nucl Med 25:432-8. 2011
    ....
  41. doi Plerixafor: a review of its use in stem-cell mobilization in patients with lymphoma or multiple myeloma
    Gillian M Keating
    Adis, a Wolters Kluwer Business, Auckland, New Zealand
    Drugs 71:1623-47. 2011
    ..blood for collection and subsequent autologous stem-cell transplantation in patients who have non-Hodgkin's lymphoma (NHL) or multiple myeloma (MM) [US] and in patients who have lymphoma or MM and are poor mobilizers (EU)...
  42. pmc Serum levels of 25-hydroxyvitamin D and survival in Norwegian patients with cancer of breast, colon, lung, and lymphoma: a population-based study
    Steinar Tretli
    The Cancer Registry of Norway, Institute of Population Based Cancer Research, Majorstuen, 0304 Oslo, Norway
    Cancer Causes Control 23:363-70. 2012
    ..We investigated the association between serum levels of 25-hydroxyvitamin D (25-OHD) and risk of death in Norwegian cancer patients...
  43. doi Janus kinase deregulation in leukemia and lymphoma
    Edwin Chen
    Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Immunity 36:529-41. 2012
    ....
  44. ncbi Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma
    Hiroyuki Imanishi
    Department of Pediatrics, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Hum Genet 52:166-71. 2007
    Methotrexate is administered in high doses to treat childhood acute lymphoblastic leukemia and malignant lymphoma. Hepatotoxicity and bone marrow suppression often limit its use, however...
  45. ncbi A novel canine lymphoma cell line: a translational and comparative model for lymphoma research
    William C Kisseberth
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Leuk Res 31:1709-20. 2007
    A novel canine lymphoma cell line, OSW, was established from the malignant pleural effusion of a dog with peripheral T-cell lymphoma...
  46. doi Target of rapamycin signaling in leukemia and lymphoma
    Collin Vu
    Division of Hematology Oncology, Department of Medicine, University of California Irvine, CA 92697, USA
    Clin Cancer Res 16:5374-80. 2010
    ..Here we discuss different strategies to inhibit TOR for the treatment of leukemia, lymphoma, and myeloma. The TOR enzyme exists in two complexes in cells, TORC1 and TORC2...
  47. pmc Signal transduction inhibitor therapy for lymphoma
    Thomas E Witzig
    Division of Hematology, Department of Internal Medicine, Mayo Clinic College of Medicine and Mayo Foundation, Rochester, MN 55905, USA
    Hematology Am Soc Hematol Educ Program 2010:265-70. 2010
    Current research in lymphoma is focused on two areas of lymphoma biology-the signal transduction pathways used to maintain the growth of malignant lymphocytes and the role of the tumor microenvironment in lymphoma growth and survival...
  48. pmc Age, gender, and racial differences in incidence and survival in primary CNS lymphoma
    J L Villano
    Department of Medicine, Section of Hematology Oncology, University of Illinois at Chicago, Chicago, IL, USA
    Br J Cancer 105:1414-8. 2011
    Primary central nervous system lymphoma (PCNSL) is a rare subtype of extranodal non-Hodgkin lymphoma that accounts for ~4% of newly diagnosed central nervous system (CNS) tumours...
  49. pmc Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile
    Richard G Jenner
    Wohl Virion Centre, Department of Immunology and Molecular Pathology, Windeyer Institute, University College London, London W1T 4JF, United Kingdom
    Proc Natl Acad Sci U S A 100:10399-404. 2003
    ..herpesvirus is associated with three human tumors: Kaposi's sarcoma, and the B cell lymphomas, plasmablastic lymphoma associated with multicentric Castleman's disease, and primary effusion lymphoma (PEL)...
  50. doi Ocular adnexal lymphoma associated with IgG4+ chronic sclerosing dacryoadenitis: a previously undescribed complication of IgG4-related sclerosing disease
    Wah Cheuk
    Department of Pathology, Queen Elizabeth Hospital, Wylie Road, Kowloon, Hong Kong
    Am J Surg Pathol 32:1159-67. 2008
    ..We report 3 cases of ocular adnexal lymphoma arising in IgG4-related chronic sclerosing dacryoadenitis, a phenomenon that has not been previously reported...
  51. pmc Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality
    Lara S Collier
    Department of Genetics, Masonic Cancer Center and Masonic Cancer Center Histopathology Core, University of Minnesota, Minneapolis, Minnesota, USA
    Cancer Res 69:8429-37. 2009
    ..In previous studies, efficient leukemia/lymphoma formation on an otherwise wild-type genetic background occurred in mice undergoing whole-body mobilization of ..
  52. pmc Proposed classification of lymphoid neoplasms for epidemiologic research from the Pathology Working Group of the International Lymphoma Epidemiology Consortium (InterLymph)
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
    Blood 110:695-708. 2007
    ..On behalf of the International Lymphoma Epidemiology Consortium (InterLymph) Pathology Working Group, we present a proposed nested classification of ..
  53. ncbi Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases
    S A Pileri
    Service of Pathologic Anatomy and Hematopathology, Institute of Haematology and Clinical Oncology L e A Seràgnoli, Bologna University, Italy
    Histopathology 41:1-29. 2002
    ..complete, rational immunophenotypic classification of histiocytic/dendritic cell neoplasms, the International Lymphoma Study Group (ILSG) stained 61 tumours of suspected histiocytic/dendritic cell type with a panel of 15 antibodies ..
  54. ncbi Extremely potent, rapid and costimulation-independent cytotoxic T-cell response against lymphoma cells catalyzed by a single-chain bispecific antibody
    Torsten Dreier
    Micromet AG, Am Klopferspitz 19, 82152 Martinsried, Germany
    Int J Cancer 100:690-7. 2002
    ..on an anti-CD19/anti-CD3 single-chain bispecific antibody (bscCD19xCD3) exhibiting high activity against human B lymphoma cell lines (Löffler et al., Blood 2000;95:2098-103)...
  55. ncbi Buthionine sulfoximine enhancement of arsenic trioxide-induced apoptosis in leukemia and lymphoma cells is mediated via activation of c-Jun NH2-terminal kinase and up-regulation of death receptors
    Duo Chen
    Division of Hematology Oncology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029 6547, USA
    Cancer Res 66:11416-23. 2006
    ..These observations suggest that a DR-mediated pathway activated by JNK is involved in apoptosis induced by treatment with As(2)O(3) plus BSO...
  56. pmc Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells
    Li Wang
    Department of Molecular and Cellular Biochemistry, Ohio State University College of Medicine, Columbus, OH 43210, USA
    Mol Cell Biol 28:6262-77. 2008
    ....
  57. pmc Phenoxy herbicides and chlorophenols: a case control study on soft tissue sarcoma and malignant lymphoma
    J G Smith
    Statistical Centre, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
    Br J Cancer 65:442-8. 1992
    A case control study on patients with soft tissue sarcoma and malignant lymphoma was undertaken to test whether there was any association between these diseases and past exposure to chlorinated phenoxy acid herbicides or chlorophenols...
  58. ncbi Bacterial infection and MALT lymphoma
    Julie Parsonnet
    Department of Medicine, Stanford University Medical Center, Stanford, Calif, USA
    N Engl J Med 350:213-5. 2004
  59. ncbi In vitro canine distemper virus infection of canine lymphoid cells: a prelude to oncolytic therapy for lymphoma
    Steven E Suter
    Department of Surgical and Radiological Science, School of Veterinary Medicine, University of California, 2112 Tupper Hall, One Shields Avenue, Davis, CA 95616, USA
    Clin Cancer Res 11:1579-87. 2005
    Measles virus (MV) causes the regression of human lymphoma xenografts...
  60. ncbi Inhibition of NF-kappaB induces apoptosis of KSHV-infected primary effusion lymphoma cells
    S A Keller
    Weill Graduate School of Medical Sciences of Cornell University, and the Departments of Medicine and Pathology of Weill Medical College of Cornell University, New York, NY, USA
    Blood 96:2537-42. 2000
    ..8 (HHV-8), is a gamma-herpesvirus that infects human lymphocytes and is associated with primary effusion lymphoma (PEL). Currently, the role of viral infection in the transformation of PEL cells is unknown...
  61. pmc Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
    Ravi K Amaravadi
    Division of Hematology Oncology, Department of Medicine, Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 117:326-36. 2007
    ..To address this issue, the role of autophagy in a Myc-induced model of lymphoma generated from cells derived from p53ER(TAM)/p53ER(TAM) mice (with ER denoting estrogen receptor) was examined...
  62. pmc Human endogenous retrovirus K (HML-2) elements in the plasma of people with lymphoma and breast cancer
    Rafael Contreras-Galindo
    University of Michigan Medical Center, 5220 MSRB III, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5640, USA
    J Virol 82:9329-36. 2008
    ..using immunoelectron microscopy, we show the presence of HERV-K (HML-2) virus-like particles in the plasma of lymphoma patients...
  63. pmc Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development
    Osamu Hashizume
    Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8572, Japan
    Proc Natl Acad Sci U S A 109:10528-33. 2012
    ..mouse embryonic stem cells, we provide convincing evidence supporting part of the abovementioned hypothesis by showing that G13997A mtDNA regulates diabetes development, lymphoma formation, and metastasis--but not aging--in this model.
  64. pmc Origin of chromosomal translocations in lymphoid cancer
    Andre Nussenzweig
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 141:27-38. 2010
    ..Deciphering the mechanisms that mediate chromosomal fusions will open new avenues for developing therapeutic strategies aimed at eliminating lesions that lead to the initiation, maintenance, and progression of cancer...
  65. pmc Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma
    Jonathan H Schatz
    Cancer Biology and Genetics Program, Sloan Kettering Institute for Cancer Research, New York, NY 10065, USA
    J Exp Med 208:1799-807. 2011
    ..Here, we show that PIM kinase expression can affect the clinical outcome of lymphoma chemotherapy. We observe the same in animal lymphoma models...
  66. pmc Blocking autophagy prevents bortezomib-induced NF-κB activation by reducing I-κBα degradation in lymphoma cells
    Li Jia
    Centre for Haemato Oncology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    PLoS ONE 7:e32584. 2012
    ..induces effective proteasome inhibition and accumulation of poly-ubiquitinated proteins in diffuse large B-cell lymphoma (DLBCL) cells...
  67. pmc Activating Notch1 mutations in mouse models of T-ALL
    Jennifer O'Neil
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 107:781-5. 2006
    ..Thus, Notch1 mutations are often acquired as a part of the molecular pathogenesis of T-ALLs that develop in mice with known predisposing genetic alterations...
  68. pmc Targeted therapy in lymphoma
    Patrick B Johnston
    Novartis Pharmaceuticals, Florham Park, NJ, USA
    J Hematol Oncol 3:45. 2010
    Discovery of new treatments for lymphoma that prolong survival and are less toxic than currently available agents represents an urgent unmet need...
  69. ncbi BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas
    Joost Kluiver
    Department of Pathology and Laboratory Medicine, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    J Pathol 207:243-9. 2005
    ..Most non-HL subtypes were negative for BIC as determined by RNA-ISH. However, in diffuse large B cell lymphoma (DLBCL) and primary mediastinal B cell lymphoma (PMBL), significant percentages of positive tumour cells were ..
  70. pmc Interaction of MEQ protein and C-terminal-binding protein is critical for induction of lymphomas by Marek's disease virus
    Andrew C Brown
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom
    Proc Natl Acad Sci U S A 103:1687-92. 2006
    ..Engineering MDV with precisely defined attenuating mutations, therefore, represents an effective strategy for generating new vaccines against this major poultry disease...
  71. ncbi Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
    L Johnson
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Nature 410:1111-6. 2001
    ..This approach has several advantages over traditional transgenic strategies, including that it more closely recapitulates spontaneous oncogene activation as seen in human cancers...
  72. ncbi Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug
    P W Gout
    Department of Cancer Endocrinology, BC Cancer Agency, Vancouver, Canada
    Leukemia 15:1633-40. 2001
    ..Its inhibition could lead to cyst(e)ine deficiency in lymphoma cells via reduction of both their cystine uptake and cysteine supply by somatic cells...
  73. pmc Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe
    Martins Kalejs
    Biomedical Research and Study Centre, Latvian University, Ratsupites 1, Riga, LV 1067, Latvia
    BMC Cancer 6:6. 2006
    We have previously reported that p53 mutated radioresistant lymphoma cell lines undergo mitotic catastrophe after irradiation, resulting in metaphase arrest and the generation of endopolyploid cells...
  74. doi Runx1 promotes B-cell survival and lymphoma development
    Karen Blyth
    Faculty of Veterinary Medicine, Molecular Oncology Laboratory, Institute of Comparative Medicine, University of Glasgow, Glasgow, UK
    Blood Cells Mol Dis 43:12-9. 2009
    ..Together these data provide formal proof that wild type Runx1 can promote oncogenesis in lymphoid tissues and that, in addition to loss of function, gain of function may have an aetiological role in leukemia...
  75. doi The staging and treatment of multicentric high-grade lymphoma in dogs: a review of recent developments and future prospects
    Laura Marconato
    Animal Oncology and Imaging Center, 6331 Hünenberg, Switzerland
    Vet J 188:34-8. 2011
    In recent years, considerable progress has been made in understanding the biology of canine lymphoma with resultant enhanced classification schemes and the possibility of individualised, tailored therapies...
  76. doi SOD/catalase mimetic platinum nanoparticles inhibit heat-induced apoptosis in human lymphoma U937 and HH cells
    Yoko Yoshihisa
    Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Free Radic Res 45:326-35. 2011
    ..HT)-induced apoptosis and the underlying molecular mechanisms were investigated in human myelomonocytic lymphoma U937 and human cutaneous T-cell lymphoma HH cells...
  77. pmc Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels
    Leo Kretzner
    Department of Translational Research, Clinical and Molecular Pharmacology, City of Hope and Beckman Research Institute, Duarte, California, USA
    Cancer Res 71:3912-20. 2011
    ..Growth and survival of multiple lymphoma cell lines were studied with either drug alone or in combination with vorinostat, a histone deacetylase inhibitor ..
  78. pmc B lymphocytes promote lymphogenous metastasis of lymphoma and melanoma
    Alanna Ruddell
    Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    Neoplasia 13:748-57. 2011
    ..tumor spread of subcutaneously implanted lymphomas, suggesting that TDLN metastasis secondarily drives lymphoma spread to distant organs...
  79. pmc The lack of evidence for PET or PET/CT surveillance of patients with treated lymphoma, colorectal cancer, and head and neck cancer: a systematic review
    Kamal Patel
    Institute of Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA
    J Nucl Med 54:1518-27. 2013
    ..PET and PET/CT are widely used for surveillance of patients after cancer treatments. We conducted a systematic review to assess the diagnostic accuracy and clinical impact of PET and PET/CT used for surveillance in several cancers...
  80. ncbi Salvage whole brain radiotherapy for recurrent or refractory primary CNS lymphoma
    Andreas F Hottinger
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Neurology 69:1178-82. 2007
    High-dose methotrexate (MTX) and whole brain radiation therapy (WBRT) prolong survival in primary CNS lymphoma (PCNSL) patients but have been associated with delayed neurotoxicity...
  81. doi Anaplastic lymphoma kinase in human cancer
    Antonella Barreca
    Department of Pathology and Center for Experimental Research and Medical Studies CeRMS, University of Torino, Via Santena 7, Torino 10126, Italy
    J Mol Endocrinol 47:R11-23. 2011
    ..Their pivotal function has been firmly established in the pathogenesis of many cancers as well. The anaplastic lymphoma kinase (ALK), a transmembrane RTK, originally identified in the nucleophosmin (NPM)-ALK chimera of anaplastic ..
  82. doi Identification of biological functions and gene networks regulated by heat stress in U937 human lymphoma cells
    Yukihiro Furusawa
    Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930 0194, Japan
    Int J Mol Med 28:143-51. 2011
    ..These findings provide the molecular basis for a further understanding of the mechanisms of the biological changes that are responsive to heat stress in human lymphoma cells.
  83. pmc miR-155 regulates HGAL expression and increases lymphoma cell motility
    Liat Nadav Dagan
    Division of Hematology Oncology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, FL 33136, USA
    Blood 119:513-20. 2012
    HGAL, a prognostic biomarker in patients with diffuse large B-cell lymphoma and classic Hodgkin lymphoma, inhibits lymphocyte and lymphoma cell motility by activating the RhoA signaling cascade and interacting with actin and myosin ..
  84. doi Phase II study of sorafenib in patients with relapsed or refractory lymphoma
    Anna Guidetti
    Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
    Br J Haematol 158:108-19. 2012
    ..Sorafenib was well tolerated and had a clinical activity that warrants development of combination regimens...
  85. ncbi Monitoring therapy in canine malignant lymphoma and leukemia with serum thymidine kinase 1 activity--evaluation of a new, fully automated non-radiometric assay
    Henrik P von Euler
    Center of Clinical Comparative Oncology, Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, and Uppsala University Hospital, Uppsala, Sweden
    Int J Oncol 34:505-10. 2009
    ..methods, which have limited the clinical use of this biomarker, although recent studies in dogs with malignant lymphoma (ML) demonstrate its wide potential...
  86. doi Use of PET in the diagnosis of primary CNS lymphoma in patients with atypical MR findings
    Nobuyuki Kawai
    Department of Neurological Surgery, Kagawa University, Faculty of Medicine, 1750 1 Miki cho, Kita gun, Kagawa, 761 0793, Japan
    Ann Nucl Med 24:335-43. 2010
    The diagnosis of primary central nervous system lymphoma (PCNSL) in immunocompetent patients with atypical magnetic resonance (MR) findings such as disseminated lesions or no (non-enhancing) lesion is sometimes difficult because of ..
  87. pmc Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice
    Xiaohe Liu
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Clin Invest 120:2497-507. 2010
    ..Targeted deletion of Pten in T cells induces both a disseminated "mature phenotype" lymphoma and a lymphoproliferative autoimmune syndrome in mice...
  88. pmc Helicobacter pylori in the pathogenesis of gastric cancer and gastric lymphoma
    Sung Soo Kim
    Department of Internal Medicine, Uijongbu St Mary Hospital, Catholic University of Korea, Seoul, Republic of Korea
    Cancer Lett 305:228-38. 2011
    ..Helicobacter pylori is strongly associated with the development of distal gastric carcinoma and gastric mucosal lymphoma in humans. Eradication of H...
  89. pmc Obesity and the risk for a hematological malignancy: leukemia, lymphoma, or myeloma
    Marshall A Lichtman
    University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642 0001, USA
    Oncologist 15:1083-101. 2010
    ..A significant association between the risk for non-Hodgkin's lymphoma and elevated BMI was supported by a meta-analysis of 13 cohort and nine case-control studies...
  90. pmc Definition of an enhanced immune cell therapy in mice that can target stem-like lymphoma cells
    Christopher H Contag
    Department of Pediatrics, Stanford University, Stanford, California, USA
    Cancer Res 70:9837-45. 2010
    Current treatments of high-grade lymphoma often have curative potential, but unfortunately many patients relapse and develop therapeutic resistance...
  91. pmc Rituximab infusion induces NK activation in lymphoma patients with the high-affinity CD16 polymorphism
    Suresh Veeramani
    Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA
    Blood 118:3347-9. 2011
    ..NK activation, blood was evaluated before and 4 hours after initiation of the initial dose of rituximab in 21 lymphoma subjects...
  92. doi Retrospective and prospective studies of hepatitis B virus reactivation in malignant lymphoma with occult HBV carrier
    N Fukushima
    Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan
    Ann Oncol 20:2013-7. 2009
    In surface antigen of hepatitis B virus (HBsAg)-positive carrier for anticancer treatment of malignant lymphoma, it is well recognized that reactivation of hepatitis B virus (HBV) occasionally occurs...
  93. pmc Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma
    Gaofeng Fan
    Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey UMDNJ Robert Wood Johnson Medical School, Piscataway, USA
    Blood 115:3559-69. 2010
    ..mutants of Bfl-1 display increased stability and greatly accelerated tumor formation in a mouse model of leukemia/lymphoma. We also show that tyrosine kinase Lck is up-regulated and activated in these tumors and leads to activation of ..
  94. ncbi Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis
    Elena Ruiz-Ballesteros
    Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas, C Melchor Fernandez Almagro 3, E 28 029 Madrid, Spain
    Blood 106:1831-8. 2005
    Splenic marginal zone lymphoma (SMZL) is a newly recognized lymphoma type whose precise molecular pathogenesis is still essentially unknown. This hampers differential diagnosis with other small B-cell malignancies...
  95. ncbi The role of FDG-PET scans in patients with lymphoma
    Pamela Seam
    National Cancer Institute, Bethesda, MD, USA
    Blood 110:3507-16. 2007
    ..the interpretation of PET scans because of technical limitations, variability of FDG avidity among the different lymphoma histologic subtypes, and in the large number of etiologies of false-negative and false-positive results...
  96. doi Expression of syncytin in leukemia and lymphoma cells
    Yi Sun
    Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming 650223, China
    Leuk Res 34:1195-202. 2010
    ..Results showed that syncytin was found to be expressed in all nine leukemia and lymphoma cell lines studied albeit at different levels and in 43 peripheral blood samples of 57 leukemia or lymphoma ..
  97. pmc Targeting neuropilin-1 in human leukemia and lymphoma
    Katja Karjalainen
    David H Koch Center, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Blood 117:920-7. 2011
    ..Finally, our results confirmed increased expression of NRP-1 in representative human leukemia and lymphoma cell lines and in a panel of bone marrow specimens obtained from patients with acute lymphoblastic leukemia or ..
  98. pmc Hydrogen protects mice from radiation induced thymic lymphoma in BALB/c mice
    Luqian Zhao
    Department of Radiation Medicine, Second Military Medical University, Xiangyin Road, Shanghai 200433, PR China
    Int J Biol Sci 7:297-300. 2011
    Ionizing radiation (IR) is a well-known carcinogen, however the mechanism of radiation induced thymic lymphoma is not well known...
  99. pmc Hydrogen peroxide signaling is required for glucocorticoid-induced apoptosis in lymphoma cells
    Margaret E Tome
    Department of Pathology, University of Arizona, Tucson, AZ 85724, USA
    Free Radic Biol Med 51:2048-59. 2011
    ..In this study, we found that glucocorticoid treatment of WEHI7.2 murine thymic lymphoma cells increased the steady-state [H(2)O(2)] and oxidized the intracellular redox environment before cytochrome c ..
  100. pmc Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice
    Carolina Vicente-Dueñas
    Experimental Therapeutics and Translational Oncology Program, Instituto de Biologia Molecular y Celular del Cancer and Institute of Biomedical Research of Salamanca, Consejo Superior de Investigaciones Científicas University of Salamanca, 37007 Salamanca, Spain
    Proc Natl Acad Sci U S A 109:10534-9. 2012
    Chromosomal translocations involving the MALT1 gene are hallmarks of mucosa-associated lymphoid tissue (MALT) lymphoma. To date, targeting these translocations to mouse B cells has failed to reproduce human disease...
  101. pmc Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model
    Cigall Kadoch
    Division of Hematology Oncology, Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
    Clin Cancer Res 15:1989-97. 2009
    The prospect for advances in the treatment of patients with primary central nervous system lymphoma (PCNSL) is likely dependent on the systematic evaluation of its pathobiology...

Research Grants81

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Rituximab is approved for the treatment of non-Hodgkin's lymphoma and rheumatoid arthritis, but is not approved for the treatment of AIR...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Rituximab is approved for the treatment of non-Hodgkin's lymphoma and rheumatoid arthritis, but is not approved for the treatment of AIR...
  3. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2010
    ..Analysis of data from case-control studies of non-Hodgkin's lymphoma noted an association with agricultural use of lindane, but not with DDT...
  4. THE AGRICULTURAL HEALTH STUDY - FIELD STATIONS
    Charles Lynch; Fiscal Year: 2010
    ..Analysis of data from case-control studies of non-Hodgkin's lymphoma noted an association with agricultural use of lindane, but not with DDT...
  5. MERVYN N WEITZMANN; Fiscal Year: 2016
    ..Rituximab, a B cell depleting antibody, used to treat B cell Non-Hodgkin's lymphoma and CTLA4-Ig (Abatacept) a costimulation inhibitor, are rapidly becoming the standard of care for refractory RA, ..
  6. Craig T Morita; Fiscal Year: 2016
    ..pyrophosphates or bisphosphonates and IL-2 to stimulate V32V42 T cells alone or in conjunction with rituximab for lymphoma has shown promise since these treatments resulted in complete and partial remissions or stable disease in ..
  7. GENETIC ANALYSIS OF POLARITY
    RUTH M STEWARD; Fiscal Year: 2010
    ..This conclusion is based on its regulation by the BCL6 (B-cell lymphoma 6) oncogene and its chromosomal localization to a region of chromosome 6q27, frequently deleted in human ..
  8. Rac GTPase signaling during embryonic salivary gland branching morphogenesis
    Sharon Sequeira; Fiscal Year: 2012
    ..acid polymer;Rac1, Ras-related C3 botulinum substrate 1;SMG, submandibular salivary gland;Tiam1, T-cell lymphoma invasion and metastasis-inducing protein 1...
  9. Inhibition of IkK to treat lethal Graft-vs.-Host Disease
    Patrick Flood; Fiscal Year: 2009
    ..stem cell transplantation (allo-SCT) is potentially curative therapy for a patients suffering from leukemia, lymphoma and multiple myeloma...
  10. Cornelia M Weyand; Fiscal Year: 2016
    ..responses but have broadly diminished immune competence, manifesting as increased susceptibility to infection, lymphoma, and cardiovascular disease...
  11. Chou Zen Giam; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): HTLV-I is the causative agent of adult T-cell leukemia/lymphoma (ATL), a malignancy of CD4+ T cells whose etiology is associated with the viral transactivator/oncoprotein, Tax...
  12. Clifford A Lowell; Fiscal Year: 2016
    ..This will lead to better design of therapeutcs to target immune diseases, as well as leukemia and lymphoma.
  13. Antibody-mediated Gene Therapy for the Treatment of Cancer
    TRACY RUTH DANIELS-WELLS; Fiscal Year: 2013
    ..gene therapy approaches for the systemic treatment of aggressive B-cell lymphomas with an emphasis on mantle cell lymphoma (MCL)...
  14. 14th International Workshop on Ataxia-Telangiectasia and ATM
    Richard A Gatti; Fiscal Year: 2010
    ..genomic instability, radiation sensitivity, and a markedly increased incidence of cancer, usually lymphoma or leukemia...
  15. Parental age at birth and risk of adult-onset cancer in female offspring
    Yani Lu; Fiscal Year: 2013
    ..of paternal age/maternal age on the risk of the 10 most common adult-onset cancers (not including non- Hodgkin lymphoma on which we have published) among U.S...
  16. Herpesvirus-induced telomerase dysregulation and tumor formation
    Keith William Jarosinski; Fiscal Year: 2011
    ..Marek's disease virus (MDV) is a herpesvirus of chickens that causes a highly malignant T cell lymphoma. MDV harbors two copies of a viral TR gene (vTR) that exhibits 88% sequence identity to chicken TR (chTR) and was ..
  17. Statins &Lymphoid Malignancy Risk in a Large Multi-Site Population-Based Cohort
    Marianne Ulcickas Yood; Fiscal Year: 2013
    ..The overall objective of this application is to examine the association between use of statins and risk of a lymphoma and whether this association is modified by the presence of conditions related to a higher risk of lymphoma...
  18. Brian Till; Fiscal Year: 2016
    ..provided by applicant): Optimization of adoptive immunotherapy with autologous CD20-specific T cells Non-Hodgkin lymphoma is diagnosed in more than 70,000 Americans each year, and aggressive B-cell lymphomas comprise approximately 35-..
  19. JULIE MARIE VOSE; Fiscal Year: 2016
    ..2) To initiate a phase III randomized clinical trial for patients with relapsed diffuse large B-cell lymphoma using Rituximab/Carmustine, Etoposide, Cytarabine, and Melphalan (R-BEAM) or Bexxar/BEAM + autologous HSCT as the ..
  20. Fnip1 Function in Lymphocyte Development, Activation and Metabolism
    Brian M Iritani; Fiscal Year: 2013
    ..Remarkably, loss of Fnip1 also protects against pre-B cell lymphoma induced by c-Myc in a mouse model of Burkitt's B cell lymphoma...
  21. Paul M Lieberman; Fiscal Year: 2015
    ..KSHV has also been implicated in several lymphoid disorders, including pleural effusion lymphoma (PEL) and Castleman's disease...
  22. Non-Hodgkin lymphoma in women: reproductive, hormonal and genetic factors
    Paige M Bracci; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Project Summary/Abstract Non-Hodgkin lymphoma in women: reproductive, hormonal and genetic factors Non-Hodgkin lymphoma (NHL) is the most common hematopoietic cancer in U.S...
  23. Montaser Shaheen; Fiscal Year: 2014
    ..hematologic malignancies? We will investigate a potential role of hPso4 in mediating chemotherapy resistance in a lymphoma cell line...
  24. Alan M Hanash; Fiscal Year: 2016
    ..leukemia/lymphoma (GVL) responses...
  25. Katrin F Chua; Fiscal Year: 2016
    ..SIRT7 is on a chromosomal region that is frequently mutated acute leukemia, lymphoma, and other aging-associated cancers, and SIRT7 protein levels are increased in tumor tissues...
  26. Celiac Disease: From Genetic Risk to Disease Development
    Susan L Neuhausen; Fiscal Year: 2009
    ..The ratio of symptomatic to asymptomatic CD is estimated to be 1:7. Some complications of CD include lymphoma, osteoporosis, anemia, miscarriages, seizures, vitamin deficiencies, and co-occurrence of other autoimmune ..
  27. Timothy L Cover; Fiscal Year: 2016
    ..sequelae of infection include gastric adenocarcinoma, duodenal ulceration, gastric ulceration, and gastric lymphoma. Gastric cancer is the second leading cause of cancer-related death worldwide, and H...
  28. Hesham M Amin; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Nucleophosmin-anaplastic lymphoma kinase-expressing anaplastic large-cell lymphoma (NPM-ALK+ ALCL) is an aggressive type of T-cell lymphoma...
  29. Live cell imaging of IgH and c-Myc gene loci and the role of nuclear organization
    Mark T Groudine; Fiscal Year: 2010
    ..active RNA polymerase II), and IgH and c-Myc are frequent translocation partners in plasmacytomas and Burkitt lymphoma. This correlation suggests that the physical proximity of these two genes within transcription factories leads to ..
  30. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2012
    ..Cancer has also been associated with herpesvirus infections. EBV is associated with Burkitt's lymphoma, other B cell neoplasias and nasopharyngeal carcinoma...
  31. Michael A Teitell; Fiscal Year: 2015
    ..Defects in this pathway were identified in pilot studies of human B cell lymphoma samples by ATM or LKB1 repression or by a recently identified somatic mutation or genetic polymorphism in CRTC2...
  32. Jacki Kornbluth; Fiscal Year: 2015
    ..of lung metastases compared with WT after injection with B16 melanoma cells and show greater dissemination of lymphoma cells to lymph nodes from the primary tumor site...
  33. Timothy W Schacker; Fiscal Year: 2014
    ..the increasing incidence of non-AIDS related cancer deaths from colon or lung cancer and non-AIDS associated lymphoma among HIV+ persons treated with ARV highlight the need for adjunctive therapies to improve immune function...
  34. Heat shock protein 90 antagonist-based therapy of mantle cell lymphoma
    Kapil Bhalla; Fiscal Year: 2012
    ..by applicant): New treatment strategies are needed to improve the disease free survival in human mantle cell lymphoma (MCL)...
  35. INTERNATIONAL HERPESVIRUS WORKSHOP
    Jay A Nelson; Fiscal Year: 2011
    ..Cancer has also been associated with herpesvirus infections. EBV is associated with Burkitt's lymphoma, other B cell neoplasias and nasopharyngeal carcinoma...
  36. Pier Paolo Pandolfi; Fiscal Year: 2014
    ..As an example BCL6 and PLZF are critical players in the pathogenesis of Non- Hodgkin's lymphoma and Acute Promyelocytic Leukemia, respectively...
  37. Yi Sun; Fiscal Year: 2016
    ..proteasome inhibitor, approved by FDA for the treatment of relapsed/refractory multiple myeloma and mantle cell lymphoma. To this end, we have focused on SCF (Skp1-Cullin-F-box proteins) E3 ubiquitin ligases, also known as CRLs (..
  38. Chou Zen Giam; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): HTLV-I is the causative agent of adult T-cell leukemia/lymphoma (ATL). HTLV-1 oncoprotein Tax is known to induce DNA damage, micronuclei formation, multinucleation, and DNA aneupoidy...
  39. Hao Wu; Fiscal Year: 2014
    ..domain (CARD) membrane-associated guanylate kinase (MAGUK) protein 1, also known as CARD11], Bcl10 (B-cell lymphoma 10) and MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) acts downstream of PKC? and ..
  40. Resham Bhattacharya; Fiscal Year: 2016
    ..Bmi-1 (B lymphoma mouse Moloney leukemia virus insertion region) regulates the self-renewal of normal stem and progenitor cells...
  41. Inflammatory Proteases, Ubiquitin Proteasome System, and Myocyte Death
    Abdelkarim Sabri; Fiscal Year: 2012
    ..The proto-oncogene Casitas b-lineage lymphoma (Cbl) is an adaptor protein with an intrinsic E3 ubiquitin ligase activity that targets receptor tyrosine kinase ..
  42. Targeting Kinases that Phosphorylate the KSHV LANA Chromatin Binding Domain
    S Diane Hayward; Fiscal Year: 2013
    ..KSHV is associated with the endothelial malignancy Kaposi sarcoma (KS) and the B cell cancers primary effusion lymphoma (PEL) and multicentric Castleman disease...
  43. Regulation of non-histone protein functions by histone deacetylases
    Edward Seto; Fiscal Year: 2010
    ..About 20% of AT patients develop cancer, most frequently acute lymphocytic leukemia or lymphoma. The ataxiatelangiectasia group D complementing (ATDC) gene was originally isolated on the basis of its ability ..
  44. The in vivo role of the mitochondrial p53 cell death program
    UTE MARTHA MOLL; Fiscal Year: 2013
    ..Retroviral gene transfer of mitochondrial targeted wild-type p53 in a cMyc-driven mouse model of Burkitt's lymphoma shows effective tumor killing of p53-null, ARF-null and p53-mutant tumor cells in vivo...
  45. Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
    Joan Lappe; Fiscal Year: 2013
    ..with calcium and vit D3 on incidence of specific cancers: breast, lung, colon and myeloma, leukemia, lymphoma. 7...
  46. Murine Models for Mantle Cell Lymphoma: The role of tumor initiating cells (TIC)
    Richard J Ford; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Mantle cell lymphoma (MCL) is the most therapy-resistant;B cell, non-Hodgkin's lymphoma (NHL-B) that currently lacks adequate therapy, and is increasing in incidence in the USA...
  47. Jack T Stapleton; Fiscal Year: 2016
    ..A recent large, Canadian, population-based case- control study found an association between GBV-C and non-Hodgkin lymphoma (NHL;odds ratio of 2.72 [95% CI 1.22-6.69])...
  48. Bc12 regulates osteoclast survival
    Junro Yamashita; Fiscal Year: 2010
    ..We have found, in preliminary studies, that homozygous mutant mice for B-cell leukemia/lymphoma 2 (Bcl2-/-) have altered hematopoietic components and high bone mass with suppressed osteoclast numbers, and that ..
  49. Development of Vaccine Strategies to prevent EBV+ Lymphoma in Patients with HIV
    ROBERT ALAN BAIOCCHI; Fiscal Year: 2010
    ..With the support of Leukemia Lymphoma Society and corporate partners, we have recently completed a large scale purification of BZLF1 and are initiating ..
  50. Lisa K Denzin; Fiscal Year: 2014
    ..is the underlying cause of many diseases including immune deficiency, anemia, autoimmunity, leukemia, and lymphoma. Basic research over the last 50+ years has allowed for the description of stem cell activity and has facilitated ..
  51. Physiologic Regulation of Hematopoiesis by Notch
    Nadia Carlesso; Fiscal Year: 2011
    ..Of note, SKP2 overexpression, is frequently altered in leukemias and lymphoma. To address the physiological relevance of these results we investigated the BM response during inflammatory ..
  52. Regulation and Role of Ornithine Decarboxylase in Cell Proliferation and Cancer
    John L Cleveland; Fiscal Year: 2013
    ..Using validated Myc-driven mouse models of B cell lymphoma and mammary adenocarcinoma, and of K-Ras-directed lung adenocarcinoma, we will test the roles of Odc in oncogene-..
  53. Basis for Lymphomagenesis in Akt2 Transgenic Mice
    Joseph R Testa; Fiscal Year: 2013
    ABSTRACT AKT plays a central role in tumorigenesis and is frequently activated in human lymphoma. v-akt is an oncogene harbored by a retrovirus that induced thymic T-cell lymphomas in mice, and transgenic mice expressing constitutively ..
  54. Martin G Pomper; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Great strides have been made in the management of lymphoma with therapies tailored to particular cell types, e.g., those expressing the B cell surface molecule CD20...
  55. Elliott D Kieff; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Epstein Barr Virus (EBV) is a prominent cause of African Burkitt's Lymphoma, Hodgkin's Lymphomas, malignant Lymphoproliferative Diseases in immune suppressed and HIV infected people, ..
  56. Peter Demant; Fiscal Year: 2014
    ..as doxorubicin) are highly effective in treatment of hematologic malignancies (including Hodgkin and non-Hodgkin lymphoma), and many childhood cancers where they are responsible for a significant part of the spectacular increase in ..
  57. Jack T Stapleton; Fiscal Year: 2016
    ..g. cryoglobulinemia), chronic inflammation and/or decreased immune surveillance (e.g. non-Hodgkins lymphoma [NHL])...
  58. ROLF F RENNE; Fiscal Year: 2015
    ..type 8, is associated with Kaposi's sarcoma (KS) and two lymphoproliferative diseases: primary effusion lymphoma (PEL) and a subset of Multicentric Castleman's disease (MCD) (1-3)...
  59. KEVIN CHARLES OEFFINGER; Fiscal Year: 2015
    ..Study 1. Promoting breast cancer surveillance and reducing health disparities among female Hodgkin lymphoma survivors treated for a pediatric or young adult cancer with chest radiation...
  60. Improved idiotype immunotherapy for lymphoma by RNA vaccine delivery
    ALISON ANNE MCCORMICK; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): In recent years, Non-Hodgkin's lymphoma (NHL) has risen to be the most common hematologic malignancy in the United States...
  61. Biomarkers to Guide Treatment and Improve Survival in Oral/Oropharyngeal Cancer
    Thomas E Carey; Fiscal Year: 2012
    ..These survival rates are poorer than those for lymphoma, breast cancer and malignant melanoma...
  62. Carol Prives; Fiscal Year: 2015
    ..our research has become more translational and relevant to human disease, now focusing on breast, bladder and lymphoma tumor genesis...
  63. Anti-Idiotype Therapy of Human B Cell Malignancy
    Ronald Levy; Fiscal Year: 2007
    Abstract[unreadable] The goal of this project is to develop a new method of treatment for Human B cell lymphoma. The immunoglobulin made by each malignant B cell tumor (idiotype) is unique and has been proven to be an effective target for ..
  64. MAPPING AND CLONING TRANSLOCATION BREAKPOINTS
    Janet Rowley; Fiscal Year: 2004
    DESCRIPTION: (adapted from the applicant's abstract) Malignant cells from human leukemia and lymphoma have a very high frequency of chromosome abnormalities, especially translocations...
  65. Molecular Epidemiology of non-Hodgkin Lymphoma Survival
    James R Cerhan; Fiscal Year: 2010
    In 2008, over 66,000 people in the US will be diagnosed with Non-Hodgkin lymphoma (NHL), and over 19,000 will die of this cancer. Survival rates have only recently begun to improve, and the current 5-year survival rate is 66%...
  66. MOLECULAR EPIDEMIOLOGY OF AIDS-ASSOCIATED LYMPHOMA
    Otoniel Martinez Maza; Fiscal Year: 2004
    DESCRIPTION (Provided by the applicant): Non-Hodgkin' s B cell lymphoma (AIDS-lymphoma) is seen in greatly-elevated frequency in HIV-infected people, not only in North America and Europe, but worldwide...
  67. Antigen Discovery and Development of Tumor-Specific Lymphoma Immunotherapy
    Sattva S Neelapu; Fiscal Year: 2010
    ..Dr. Neelapu is a physician scientist with laboratory training in cancer immunotherapy and clinical training in lymphoma medical oncology...
  68. Environmental Risk Factors and Canine Malignant Lymphoma
    Elizabeth Bertone Johnson; Fiscal Year: 2005
    The incidence of human non-Hodgkin's lymphoma (NHL) in the US has nearly doubled over the previous 30 years...
  69. ARSENIC TRIOXIDE TREATMENT OF LYMPHOPROLIFERATIVE DISORD
    Samuel Waxman; Fiscal Year: 2003
    ..with this is our observation that As203 (1-2 M) treatment of cell lines and primary cultures of LPD (B-cell lymphoma, CLL, ALL, multiple myeloma but not T-cell lymphoma) causes significant growth inhibition and, in some cells, ..
  70. Overcoming tumor cell resistance to apoptosis with a natural product, GCS-100
    Linda G Baum; Fiscal Year: 2010
    ..of a natural product derived from citrus pectin in overcoming galectin-3 mediated resistance to apoptosis in lymphoma, and to understand the interaction of this natural product with conventional cancer agents...
  71. Cancer prevention by indole-3-carbinol via modulation of the epigenome
    Abby D Benninghoff; Fiscal Year: 2010
    ..of I3C during pregnancy and lactation markedly decreased offspring mortality due to aggressive lymphoblastic lymphoma. However, the mechanism by which I3C confers this cancer protection to the fetus is unknown...
  72. Positive and Negative Regulatory Pathways In Human Lymphoma
    Richard Ford; Fiscal Year: 2007
    ..molecular aggregate, called a Signalosome within a lipid raft microdomains, contained within or subjacent to the lymphoma cell membrane...
  73. THERAPY FOR AIDS CENTRAL NERVOUS SYSTEM LYMPHOMA
    Michael Caligiuri; Fiscal Year: 2002
    ..survival for patients with the acquired immune deficiency syndrome diagnosed with primary central nervous system lymphoma (AIDS PCNSL) is less than four months, despite radio- and chemotherapy and recent improvements in the suppression ..
  74. OLIGONUCLEOTIDE INHIBITION OF CELL PROLIFERATION
    Eric Wickstrom; Fiscal Year: 2000
    ..trials of oligonucleotide therapeutics have demonstrated antisense efficacy in patients against follicular lymphoma, chronic myelogenous leukemia, cytomegalovirus and Crohn's disease...
  75. SPORE in Lymphoma
    Richard Ambinder; Fiscal Year: 2009
    Our goal is to investigate whether in Hodgkins lymphoma (HL) molecular markers can inform decisions regarding the duration or intensity of therapy and to determine whether vaccination and/or adoptive immunotherapy strategies may ..
  76. BC1-2 REARRANGEMENTS IN CLL
    Louise Showe; Fiscal Year: 1992
    ..Follicular lymphoma is one of the most common hematopoietic tumors in the United States and has been shown to carry a specific ..