Summary: A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)

Top Publications

  1. ncbi Coincidental development of forestomach papilloma and prepyloric ulcer in nontreated mutant mice of W/Wv and SI/SId genotypes
    Y Kitamura
    Cancer Res 40:3392-7. 1980
  2. ncbi Identification of genes and gene ontology processes critical to skin papilloma development in Tg.AC transgenic mice
    Hong Dang
    Alpha Gamma Technologies, Inc, Raleigh, North Carolina, USA
    Mol Carcinog 45:126-40. 2006
  3. ncbi Risk of breast cancer associated with papilloma
    R Sakr
    Department of Gynecology, Hopital Tenon, 4 rue de la Chine, 75020 Paris, France
    Eur J Surg Oncol 34:1304-8. 2008
  4. pmc The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development
    Kyung Soo Chun
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 30:1620-7. 2009
  5. pmc Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications
    Erika L Abel
    Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, Texas, USA
    Nat Protoc 4:1350-62. 2009
  6. ncbi Recurrent respiratory papillomatosis: a review
    Craig S Derkay
    Department of Otolaryngology Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Laryngoscope 118:1236-47. 2008
  7. ncbi Characterization of novel bovine papillomavirus type 12 (BPV-12) causing epithelial papilloma
    Wei Zhu
    Department of Veterinary Microbiology, University of Miyazaki, 1 1 Gakuen Kibanadai Nishi, Miyazaki 889 2192, Japan
    Arch Virol 157:85-91. 2012
  8. ncbi Detection of bovine papillomavirus type 2 in the peripheral blood of cattle with urinary bladder tumours: possible biological role
    Sante Roperto
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Naples, Italy
    J Gen Virol 89:3027-33. 2008
  9. pmc Recurrent respiratory papillomatosis: a complex defect in immune responsiveness to human papillomavirus-6 and -11
    Vincent R Bonagura
    Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY, USA
    APMIS 118:455-70. 2010
  10. ncbi Distinct genetic loci control development of benign and malignant skin tumours in mice
    H Nagase
    CRC Beatson Laboratories, Department of Medical Oncology, University of Glasgow, UK
    Nat Genet 10:424-9. 1995

Detail Information

Publications274 found, 100 shown here

  1. ncbi Coincidental development of forestomach papilloma and prepyloric ulcer in nontreated mutant mice of W/Wv and SI/SId genotypes
    Y Kitamura
    Cancer Res 40:3392-7. 1980
    ..Coincidental development of forestomach papilloma and prepyloric ulcer was observed in about 40% of nontreated (WB X C57BL/6) F1-W/Wv mice raised in our ..
  2. ncbi Identification of genes and gene ontology processes critical to skin papilloma development in Tg.AC transgenic mice
    Hong Dang
    Alpha Gamma Technologies, Inc, Raleigh, North Carolina, USA
    Mol Carcinog 45:126-40. 2006
    This study analyzes gene expression associated with papilloma development in Tg.AC v-Ha-ras transgenic mice and identifies novel genes and biological processes that may be critical to skin carcinogenesis in these mice...
  3. ncbi Risk of breast cancer associated with papilloma
    R Sakr
    Department of Gynecology, Hopital Tenon, 4 rue de la Chine, 75020 Paris, France
    Eur J Surg Oncol 34:1304-8. 2008
    The purpose of this study was to investigate the risk of carcinoma in patients with a diagnosis of papilloma of the breast made on ultrasound large core biopsy or stereotactic vacuum-assisted biopsies.
  4. pmc The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development
    Kyung Soo Chun
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Carcinogenesis 30:1620-7. 2009
    ..TPA)-promoted papillomas and that PKA and EGFR inhibition (H89 and AG1478, respectively) decreased papilloma formation...
  5. pmc Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications
    Erika L Abel
    Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, Texas, USA
    Nat Protoc 4:1350-62. 2009
    ..Using the protocol described here, a highly reproducible papilloma burden is expected within 10-20 weeks with progression of a portion of the tumors to squamous cell carcinomas ..
  6. ncbi Recurrent respiratory papillomatosis: a review
    Craig S Derkay
    Department of Otolaryngology Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Laryngoscope 118:1236-47. 2008
    ..The potential for a quadrivalent human papilloma vaccine is being explored to reduce the incidence of this disease.
  7. ncbi Characterization of novel bovine papillomavirus type 12 (BPV-12) causing epithelial papilloma
    Wei Zhu
    Department of Veterinary Microbiology, University of Miyazaki, 1 1 Gakuen Kibanadai Nishi, Miyazaki 889 2192, Japan
    Arch Virol 157:85-91. 2012
    Bovine papillomavirus type 12 (BPV-12, putative type BAA1) was detected in epithelial papilloma located on the tongue of an infected cow...
  8. ncbi Detection of bovine papillomavirus type 2 in the peripheral blood of cattle with urinary bladder tumours: possible biological role
    Sante Roperto
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Naples, Italy
    J Gen Virol 89:3027-33. 2008
  9. pmc Recurrent respiratory papillomatosis: a complex defect in immune responsiveness to human papillomavirus-6 and -11
    Vincent R Bonagura
    Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY, USA
    APMIS 118:455-70. 2010
    ..Taken together, RRP is a complex, multigene disease manifesting as a tissue and HPV-specific, immune deficiency that prevents effective clearance and/or control of HPV-6 and -11 infection...
  10. ncbi Distinct genetic loci control development of benign and malignant skin tumours in mice
    H Nagase
    CRC Beatson Laboratories, Department of Medical Oncology, University of Glasgow, UK
    Nat Genet 10:424-9. 1995
    ..On the other hand, probably a single locus on chromosome 5 affects both early and late stages of malignancy. The results indicate that benign and malignant tumours are largely under independent genetic control...
  11. ncbi The role of HPV type in Recurrent Respiratory Papillomatosis
    A J Donne
    Department of Otolaryngology, Alder Hey Children s NHS Foundation Trust, Eaton Road, Liverpool, L12 2AP, United Kingdom
    Int J Pediatr Otorhinolaryngol 74:7-14. 2010
    ..Human Papillomavirus (HPV) 6 and 11 are the aetiological agents responsible for Recurrent Respiratory Papillomatosis (RRP). There is general consensus that HPV11 results in more aggressive disease compared to HPV6...
  12. ncbi IFNgamma promotes papilloma development by up-regulating Th17-associated inflammation
    Mingjie Xiao
    National Laboratory of Biomacromolecules, Chinese Academy of Sciences University of Tokyo Joint Laboratory of Structural Virology and Immunology
    Cancer Res 69:2010-7. 2009
    ..influences 7,12-dimethylbenz(a)anthracene (DMBA)-induced and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced papilloma development...
  13. ncbi A critical role for ras-mediated, epidermal growth factor receptor-dependent angiogenesis in mouse skin carcinogenesis
    M Llanos Casanova
    Project on Cell and Molecular Biology and Gene Therapy, Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, 28040 Madrid, Spain
    Cancer Res 62:3402-7. 2002
    ..A large body of evidence indicates that in this model, activation of Ha-ras is the critical event in papilloma formation, a process that involves epidermal proliferation and stroma remodeling, which includes angiogenesis...
  14. ncbi Hamartomas, papillomas and adenocarcinomas of the sinonasal tract and nasopharynx
    B Perez-Ordonez
    Department of Pathology, University Health Network, Ontario M5G 2C4, Canada
    J Clin Pathol 62:1085-95. 2009
    ..tract which includes respiratory epithelial adenomatoid hamartoma, glandular (seromucinous) hamartoma, exophytic papilloma, inverted papilloma, cylindrical cell (oncocytic) papilloma, low-grade sinonasal adenocarcinoma and intestinal-..
  15. ncbi PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathways
    Denggao Yao
    Section of Squamous Cell Biology and Dermatology, Division of Cancer Sciences and Molecular Pathology, Glasgow University, Glasgow G11 6NU, Scotland, UK
    Cancer Res 66:1302-12. 2006
  16. ncbi Inhibition of CREB function in mouse epidermis reduces papilloma formation
    Julian Rozenberg
    Laboratory of Metabolism, National Cancer Institute, NIH, 37 Convent Drive, Room 2D24, Bethesda, MD 20892, USA
    Mol Cancer Res 7:654-64. 2009
    ..However, A-CREB expression one month after DMBA treatment does not prevent papilloma formation, suggesting that CREB functions at an early stage of papilloma formation...
  17. ncbi Squamous cell carcinoma arising in recurrent respiratory papillomatosis with pulmonary involvement: emerging common pattern of clinical features and human papillomavirus serotype association
    J R Cook
    Lauren V Ackerman Laboratory of Surgical Pathology, Department of Pathology, Washington University School of Medicine, St Louis, Missouri, USA
    Mod Pathol 13:914-8. 2000
  18. ncbi CT findings of bronchial glandular papilloma
    Motoo Nakagawa
    Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Thorac Imaging 23:210-2. 2008
    Solitary pulmonary papillomas are rare benign tumors in adults. Glandular papilloma is the rarest subtype among them. In this report, we describe a case of glandular papilloma that showed unique computed tomography features...
  19. ncbi c-fos is required for malignant progression of skin tumors
    E Saez
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 82:721-32. 1995
    ..These results demonstrate that a member of the AP-1 family of transcription factors is required for the development of a malignant tumor...
  20. ncbi Malignant transformation of a highly aggressive human papillomavirus type 11-associated recurrent respiratory papillomatosis
    Harrison W Lin
    Department of Otolaryngology Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Am J Otolaryngol 31:291-6. 2010
    ..The objective is to present an uncommon case of squamous cell carcinoma (SCC) arising from extensive recurrent respiratory papillomatosis (RRP) involving the upper and lower airway and temporal bone...
  21. ncbi Initial results from the national registry for juvenile-onset recurrent respiratory papillomatosis. RRP Task Force
    L R Armstrong
    Viral Exanthems and Herpesvirus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Arch Otolaryngol Head Neck Surg 125:743-8. 1999
    ..To characterize the spectrum of juvenile-onset recurrent respiratory papillomatosis (RRP) in the United States and to obtain data about the natural course of the disease and its response to treatment...
  22. ncbi [Prophylactic and therapeutic vaccines against human papilloma virus]
    A E Albers
    Hals Nasen Ohren Klinik, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Deutschland
    HNO 58:778-90. 2010
    Infection with human papilloma virus (HPV) has been identified as the cause of recurrent papillomatosis and of a subgroup of squamous cell carcinomas of the head and neck...
  23. ncbi Inverted papilloma of the nasal cavity and paranasal sinuses
    William M Mendenhall
    Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida, USA
    Am J Clin Oncol 30:560-3. 2007
    To discuss the treatment and outcomes of inverted papilloma of the nasal cavity and paranasal sinuses.
  24. ncbi Oncocytic Schneiderian papilloma
    Chia Yu Liu
    Department of Otolaryngology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Chin Med Assoc 67:255-7. 2004
    Oncocytic Schneiderian papilloma, fungiform papilloma, and inverted papilloma are 3 morphologically separate tumors arising from the Schneiderian membrane...
  25. pmc Human papillomavirus in conjunctival papilloma
    N C Sjö
    Eye Pathology Institute, University of Copenhagen, Denmark
    Br J Ophthalmol 85:785-7. 2001
    ..To examine conjunctival papillomas for the presence of human papillomavirus (HPV) and koilocytosis...
  26. ncbi Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis
    W C Weinberg
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892 4340, USA
    Cancer Res 59:2050-4. 1999
    ..b>Papilloma frequency was higher in the p21WAF1-deficient mice...
  27. ncbi Decreased focal adhesion kinase suppresses papilloma formation during experimental mouse skin carcinogenesis
    G W McLean
    Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow G61 1BD, United Kingdom
    Cancer Res 61:8385-9. 2001
    ..We found that fak +/- heterozygous mice display reduced 7,12-dimethylbenz[a]anthracene-induced papilloma formation that correlates with reduced FAK protein expression in the skin...
  28. ncbi Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors
    C J Kemp
    Cancer Research Campaign Beatson Laboratories, Beatson Institute for Cancer Research, Bearsden, Glasgow, Scotland
    Cell 74:813-22. 1993
    ..Most tumors from all groups had activating mutations in the H-ras gene. Absence of p53, therefore, does not augment the frequency of initiation or the rate of promotion but greatly enhances malignant progression...
  29. ncbi Mice lacking the p53/p63 target gene Perp are resistant to papilloma development
    Michelle R Marques
    Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Cancer Res 65:6551-6. 2005
    ..We find that mice lacking Perp in the skin are resistant to papilloma development, displaying fewer and smaller papillomas than wild-type mice...
  30. ncbi Ron tyrosine kinase receptor regulates papilloma growth and malignant conversion in a murine model of skin carcinogenesis
    Edward L Chan
    Department of Pediatrics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0558, USA
    Oncogene 24:479-88. 2005
    ..AC(+/-)) mice. In an analysis of the resulting papillomas, a reduction in cellular proliferation and papilloma volume was found in the TK(-/-) Tg.AC(+/-) mice compared to controls...
  31. ncbi Control of intracellular movement of connexins by E-cadherin in murine skin papilloma cells
    F J Hernandez-Blazquez
    Unit of Multistage Carcinogenesis, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon Cedex 08, 69372, France
    Exp Cell Res 270:235-47. 2001
    The gap junctional intercellular communication-deficient mouse skin papilloma cell line P3/22 expresses Cx43 but not E-cadherin...
  32. ncbi Serial office-based intralesional injection of cidofovir in adult-onset recurrent respiratory papillomatosis
    Johanna Co
    Department of Otolaryngology Head and Neck Surgery, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Ann Otol Rhinol Laryngol 113:859-62. 2004
    ..It might be more convenient and cost-effective than performing the same procedure in the operating room with the patient under general anesthesia...
  33. ncbi Cytogenetic studies in peripheral blood of bovines afflicted by papillomatosis
    T C Melo
    Departamento de Genetica, Universidade Federal de Pernambuco, Recife, PE, Brazil
    Vet Comp Oncol 9:269-74. 2011
    ..0001). The increased frequencies of chromosome aberrations suggest an interaction between the virus and host cell chromatin...
  34. pmc Flower-deficient mice have reduced susceptibility to skin papilloma formation
    Evgeniya Petrova
    Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro, 3, Madrid, 28034, Spain
    Dis Model Mech 5:553-61. 2012
    ..Furthermore, mFwe expression is higher in papillomas and the papilloma-surrounding skin of treated wild-type mice compared with the skin of untreated wild-type mice...
  35. pmc A solitary bronchial papilloma with unusual endoscopic presentation: case study and literature review
    Fabrice Paganin
    Service de Pneumologie, GHSR, St Pierre, France
    BMC Pulm Med 9:40. 2009
    ..A misdiagnosis is common with viral related papillomas. A histopathological classification has recently permitted a major advancement in the understanding of the disease...
  36. ncbi Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion
    P J Reddig
    Department of Human Oncology, Medical School, University of Wisconsin, Madison 53792, USA
    Cancer Res 60:595-602. 2000
    ..The papilloma burden was reduced by 95-96% for male and female T7-PKCepsilon mice compared to wild-type controls...
  37. ncbi Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature
    Manuel Deprez
    Laboratoire d Ophtalmopathologie, Hopital Ophtalmique Jules Gonin, Lausanne, Suisse
    Am J Dermatopathol 31:256-62. 2009
    ..malignant ones, representing 84% of cases in this series, and the 5 most frequent subtypes were squamous cell papilloma (26%), seborrheic keratosis (21%), melanocytic nevus (20%), hidrocystoma (8%), and xanthoma/xanthelasma (6%)...
  38. ncbi Solitary peripheral pulmonary papilloma evaluation on frozen section: a potential pitfall for the pathologist
    Lyska L Emerson
    Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, UT 84112, United States
    Pathol Res Pract 208:726-9. 2012
    Endobronchial papilloma is a rare entity that is in the differential for solitary pulmonary nodule. It almost always follows a benign course, with only rare malignant transformation being reported in the squamous variant...
  39. ncbi Eyelid tumors in children: a clinicopathologic study of a 10-year review in southern Taiwan
    Huan Chen Hsu
    Department of Ophthalmology, Chang Gung University, Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ROC
    Ophthalmologica 218:274-7. 2004
    ..To describe the clinical and histopathologic characteristics of eyelid tumors in children in southern Taiwan...
  40. ncbi Squamous papilloma with hyperpigmentation in the skin graft of the neovagina in Rokitansky syndrome: literature review of benign and malignant lesions of the neovagina
    Muhammad T Idrees
    Department of Pathology, Mount Sinai Medical Center, New York, New York, USA
    J Pediatr Adolesc Gynecol 22:e148-55. 2009
    ..It is rare for a benign or malignant neoplasm to develop in a neovagina...
  41. pmc The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development
    Richard Grose
    Centre for Tumour Biology, Institute of Cancer, Bart s and The London, Queen Mary s School of Medicine and Dentistry, London, UK
    EMBO J 26:1268-78. 2007
    ..Thus we describe a novel role of Fgfr2b and provide the first evidence of a tyrosine kinase receptor playing a tumor suppressive role in the skin...
  42. pmc Human papillomavirus in normal conjunctival tissue and in conjunctival papilloma: types and frequencies in a large series
    Nicolai Christian Sjö
    Eye Pathology Institute, University of Copenhagen, Frederik V s vej 11, DK 2100 Copenhagen Ø, Denmark
    Br J Ophthalmol 91:1014-5. 2007
    To examine conjunctival papilloma and normal conjunctival tissue for the presence of human papillomavirus (HPV).
  43. ncbi Endoscopic treatment of sinonasal papilloma: a 12 year review
    Tara Mackle
    Acta Otolaryngol 128:670-4. 2008
    Endoscopic surgical management is recommended as a viable treatment option for sinonasal papilloma, with comparable results to those treated by an external approach...
  44. ncbi High incidence of malignant transformation of laryngeal papilloma in Taiwan
    Li Ang Lee
    Department of Otolaryngology, Chang Gung Memorial Hospital, Chang Gung University, 5 Fu Shin Street, Kweishan, Taoyuan, Taiwan
    Laryngoscope 118:50-5. 2008
    Papillomas of the larynx include solitary laryngeal papilloma and recurrent respiratory papillomatosis. This study investigated the incidence of malignant transformation and assessed possible risk factors for laryngeal papillomas.
  45. ncbi Nasopharyngeal cylindrical cell papilloma
    A Chrysovergis
    First Department of Otolaryngology Head and Neck Surgery, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, Greece
    J Laryngol Otol 125:86-8. 2011
    ..Cylindrical cell papillomas are rare tumours which usually arise in the sinonasal region...
  46. ncbi Mixed squamous cell and glandular papilloma of the lung: a case study and literature review
    Kentaro Inamura
    Department of Pathology, Japanese Red Cross Medical Center, Tokyo, Japan
    Pathol Int 61:252-8. 2011
    Mixed squamous cell and glandular papilloma (mixed papilloma) of the lung is an extremely rare neoplasm, with only 10 cases reported so far in the English literature...
  47. ncbi Feline cutaneous viral papilloma associated with human papillomavirus type 9
    J S Munday
    Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11 222, Palmerston North, New Zealand
    Vet Pathol 44:924-7. 2007
    ..To the authors' knowledge, this is only the second reported feline cutaneous viral papilloma. In addition, this is the first report of a feline papilloma being associated with an HPV.
  48. ncbi Sinonasal papillomas: clinicopathologic review of 40 patients with inverted and oncocytic schneiderian papillomas
    Matthew R Kaufman
    Departments of Otolaryngology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Laryngoscope 112:1372-7. 2002
    ..To evaluate the pathological features and variations of sinonasal inverted and oncocytic papillomas and correlate the microscopic findings with the clinical behavior...
  49. ncbi Recurrent inverted papilloma with intracranial and temporal fossa involvement: A case report and review of the literature
    C M Acevedo-Henao
    Department of Radiotherapy, Morvan Hospital, CHU de Brest, Brest University, France
    Cancer Radiother 14:202-5. 2010
    Inverted papilloma (IP) is a rare nasosinusal benign tumour, with epithelium surface inversion to inside the stroma. Extension to intracranial temporal fossa and middle ear has been reported in few cases in the literature...
  50. ncbi Inverted papilloma: report of 89 cases
    Ernesto Pasquini
    Department of Otolaryngology, University of Bologna, Sant Orsola Malpighi Hospital, Italy
    Am J Otolaryngol 25:178-85. 2004
    In this study, the surgical management of an inverted papilloma of the nose and paranasal sinuses performed at our institution is reviewed.
  51. ncbi The role of immunohistochemistry in the differential diagnosis of papillary lesions of the breast
    G M Tse
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China
    J Clin Pathol 62:407-13. 2009
    ..Myoepithelial markers can help in differentiating papilloma from papillary carcinoma, as the former usually shows a continuous layer of myoepithelial cells...
  52. ncbi A rare case of oncocytic Schneiderian papilloma with intradural and intraorbital extension with notes of operative techniques
    Maurizio Bignami
    Department of Otorhinolaryngology, University of Insubria, Azienda Ospedaliera Universitaria, Ospedale di Circolo e Fondazione Macchi, Varese, Italy
    Rhinology 47:316-9. 2009
    Epithelial cells of cylindrical cell papilloma are oncocytes, which arise from the sinonasal respiratory epithelium, hence the term Oncocytic Schneiderian papilloma...
  53. pmc Cutaneous papilloma and squamous cell carcinoma therapy utilizing nanosecond pulsed electric fields (nsPEF)
    Dong Yin
    Division of Hematology Oncology, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America
    PLoS ONE 7:e43891. 2012
    ..nsPEF efficiently causes cell death in vitro and removes papillomas and squamous cell carcinoma in vivo from skin of mice. nsPEF has the therapeutic potential to remove human squamous carcinoma...
  54. ncbi [Medial maxillectomy in transitional papilloma]
    E Verhaert
    Dienst N.O.K, AZ-St. Jan, Brugge
    Acta Otorhinolaryngol Belg 46:273-8. 1992
    Transitional Papilloma, the formerly inverted papilloma, is a rather rare neoplasm of the nasal cavity. Its origin is still debated. The only constant symptom is unilateral nose obstruction...
  55. ncbi Human papilloma virus and p53 expression in carcinomas associated with sinonasal papillomas: a Danish Epidemiological study 1980-1998
    C Buchwald
    Department of Otolaryngology and Head and Neck Surgery, Rigshospitalet, Copenhagen, Denmark
    Laryngoscope 111:1104-10. 2001
    To determine a putative role and relation between human papilloma virus (HPV) and p53 in the etiology of sinonasal carcinomas associated with papillomas.
  56. ncbi The predictive value of serum interleukins in recurrent respiratory papillomatosis: a preliminary study
    R T Snowden
    Department of Otolaryngology Head and Neck Surgery, University of Tennessee Memphis, 956 Court Avenue B219, Memphis, TN 38163, U S A
    Laryngoscope 111:404-8. 2001
    ..Our objective was to determine whether a correlation existed between circulating levels of interleukin-2 as well as its soluble receptor (sIL-2R) and the clinical course of recurrent respiratory papillomatosis...
  57. ncbi Topical alpha-interferon in recurrent conjunctival papilloma
    R J W de Keizer
    Department of Ophthalmology, Leiden University Medical Centre, Leiden, The Netherlands
    Acta Ophthalmol Scand 81:193-6. 2003
    ..To report the effect of topical alpha-interferon (alpha-IF) in two cases of recurrent conjunctival papillomas...
  58. ncbi Markers of malignant transformation of sinonasal inverted papilloma
    H Katori
    Department of Otolaryngology, Yokohama City University Medical Center, 4 57 Urafune chou, Minami Ku, Yokohama 232 0024, Japan
    Eur J Surg Oncol 31:905-11. 2005
    ..growth factor receptor (EGFR) and transforming growth factor-alpha (TGF-alpha) expression and Ki-67 index in exophytic papilloma (EP), inverted papilloma (IP) with dysplasia, IP with carcinoma and invasive squamous cell carcinoma (SCC).
  59. ncbi Expression of p27, p21(WAF/Cip1), and p16(INK4a) in normal oral epithelium, oral squamous papilloma, and oral squamous cell carcinoma
    Ana Beatriz Queiroz
    Departamento de Patologida, Universidade Federal de Sao Paulo UNIFESP, Av Ana Costa, 95, Vila Mathias, Santos SP, 11060 001, Brazil
    Anticancer Res 30:2799-803. 2010
    To characterize the immunohistochemical expression of p27, p21(WAF/Cip1) and p16(INK4a) in normal oral epithelium, oral squamous papilloma and oral squamous cell carcinoma.
  60. ncbi IFN-γ-mediated downregulation of LXA4 is necessary for the maintenance of nonresolving inflammation and papilloma persistence
    Chunhui Wang
    Key Laboratory of Protein and Peptide Pharmaceuticals, Chinese Academy of Sciences, Beijing, China
    Cancer Res 73:1742-51. 2013
    ..model, we observed here that the lack of IFN-γ receptor or neutralization of IFN-γ accelerated spontaneous papilloma regression in mice...
  61. ncbi HPV types causing juvenile recurrent laryngeal papillomatosis in South Africa
    R Y Seedat
    Department of Otorhinolaryngology, Universitas Academic Hospital and University of the Free State, Bloemfontein, South Africa
    Int J Pediatr Otorhinolaryngol 74:255-9. 2010
  62. ncbi Clinical and pathological analysis of recurrent inverted papilloma
    Keita Oikawa
    Department of Otolaryngology Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Ann Otol Rhinol Laryngol 116:297-303. 2007
    We analyzed the clinical characteristics, pathological findings, and treatment outcomes of patients with recurrent sinonasal inverted papilloma (IP).
  63. ncbi Incidence, age at onset, and potential reasons of malignant transformation in recurrent respiratory papillomatosis patients: 20 years experience
    Valentin Gerein
    Department of Pediatric Pathology, Institute of Pathology, University of Mainz, Germany
    Otolaryngol Head Neck Surg 132:392-4. 2005
    ..6 +/- 6.3 years from pulmonary spread until malignant transformation) with persistent RRP in larynx. The results of long-term follow-up in RRP patients with HPV 11 underline the necessity of reanalyzing the current therapy...
  64. ncbi Can established cultured papilloma cells harbor bovine papillomavirus?
    S R C Campos
    Laboratorio de Genetica, Instituto Butantan, Sao Paulo, SP, Brasil
    Genet Mol Res 7:1119-26. 2008
    ..of cell cultures from lesions of bovine cutaneous papillomatosis, with identification of different bovine papilloma virus (BPV) DNA sequences...
  65. ncbi High uptake in schneiderian papillomas of the maxillary sinus on positron-emission tomography using fluorodeoxyglucose
    F Y Lin
    Department of Otolaryngology Head and Neck Surgery, Mount Sinai School of Medicine, New York, NY 10029, USA
    AJNR Am J Neuroradiol 30:428-30. 2009
    ..We report a case of a maxillary sinus oncocytic schneiderian papilloma first detected by positron-emission tomography by using fluorodeoxyglucose (FDG)...
  66. ncbi Oncocytic schneiderian papilloma found in a recurrent chronic paranasal sinusitis
    Tsung Yueh Cheng
    Department of Otolaryngology, Chang Gung Memorial Hospital, Taiwan, ROC
    Chang Gung Med J 29:336-41. 2006
    Oncocytic schneiderian papilloma (OSP), also known as cylindrical cell papilloma, is a rare benign sinonasal neoplasm. Due to its rare incidence, this disease is not well-understood by clinicians...
  67. ncbi HPV-induced recurrent laryngeal papillomatosis: fatty acid role-players
    Louise Louw
    University of the Free State, Department of Otorhinolaryngology, Faculty of Health Sciences, University of the Free State, Box 339 G42, Bloemfontein 9300, South Africa
    Asia Pac J Clin Nutr 17:208-11. 2008
    Human papilloma virus-induced recurrent laryngeal papillomatosis is considered a troublesome and dangerous disease, because it can cause airway obstruction...
  68. ncbi Assessment of human papilloma virus infection in adult laryngeal papilloma using a screening test
    Kiyoshi Makiyama
    Department of Otorhinolaryngology, Nihon University Surugadai Hospital, Chiyoda, Tokyo 101 8309, Japan
    J Voice 27:230-5. 2013
    Human papilloma virus (HPV) infection is involved in both juvenile and adult laryngeal papilloma. We wished to determine which types of adult laryngeal papilloma were clinically related to HPV infection...
  69. ncbi The inverted Schneiderian papilloma: a review and literature report of 43 new cases
    N J Mansell
    Department of Otolaryngology, Head and Neck Surgery, Radcliffe Infirmary, Oxford, UK
    Rhinology 38:97-101. 2000
    Inverted Schneiderian Papilloma remains a controversial nasal disease. Although a benign pathology it is associated with aggressive local destruction, recurrence after removal and malignancy...
  70. ncbi Sinus inflammation associated with contralateral inverted papilloma
    Richard R Orlandi
    Division of Otolaryngology Head and Neck Surgery, University of Utah, Salt Lake City 84132, USA
    Am J Rhinol 16:91-5. 2002
    To assess with computerized tomography (CT) the association of unilateral inverted papilloma (IP) and contralateral sinus inflammation.
  71. ncbi Recurrent respiratory papillomatosis
    Craig S Derkay
    Department of Otolaryngology, Eastern Virginia Medical School, 825 Fairfax Ave, Suite 510, Norfolk, VA 23507, USA
    Ann Otol Rhinol Laryngol 115:1-11. 2006
    ..The key to future management of recurrent respiratory papillomatosis may lie in its prevention, if current efforts to develop an effective vaccine come to fruition...
  72. ncbi Recurrent respiratory papillomatosis in children: masquerader of common respiratory diseases
    Michael C Zacharisen
    Department of Pediatrics, Section of Allergy and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Pediatrics 118:1925-31. 2006
    ..The diagnosis of recurrent respiratory papillomatosis may be challenging unless there is a high index of suspicion and awareness of the variable presentations...
  73. ncbi Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma
    L A Afonso
    Laboratório de Diagnóstico Virológico, Departamento de Microbiologia e Parasitologia, Instituto Biomedico, Universidade Federal Fluminense, Niteroi, RJ, Brasil
    Braz J Med Biol Res 43:694-6. 2010
    ..In the present study, we investigated an esophageal papilloma from a 30-year-old male patient presenting aphasia...
  74. ncbi Metastasis of a histologically benign choroid plexus papilloma: case report and review of the literature
    Ye Jinhu
    Department of Neuroradiology, Beijing Tiantan Hospital, Tiantan xili street 10, Beijing 100050, China
    J Neurooncol 83:47-52. 2007
    ..of papillary ependymoma or CPP, to our surprise, final histological examination revealed a benign choroid plexus papilloma. One month after the first operation, a metastatic nodule was found in the spinal subarachnoidal space at the ..
  75. ncbi Anti-oncogenic potentials of a plant coumarin (7-hydroxy-6-methoxy coumarin) against 7,12-dimethylbenz [a] anthracene-induced skin papilloma in mice: the possible role of several key signal proteins
    Soumya Sundar Bhattacharyya
    Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani 741235, India
    Zhong Xi Yi Jie He Xue Bao 8:645-54. 2010
    ..In the present study, its in vivo effects have been evaluated in mice...
  76. ncbi HspE7 treatment of pediatric recurrent respiratory papillomatosis: final results of an open-label trial
    Craig S Derkay
    Department of Otolaryngology Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Ann Otol Rhinol Laryngol 114:730-7. 2005
  77. ncbi The epidemiology of juvenile onset recurrent respiratory papillomatosis derived from a population level national database
    Paolo Campisi
    Hospital for Sick Children, Toronto, Ontario, Canada
    Laryngoscope 120:1233-45. 2010
  78. ncbi Optimization of cottontail rabbit papilloma virus challenge technique
    J D Reuter
    Section of Comparative Medicine, Yale University School of Medicine, LSOG 117, 375 Congress Avenue, New Haven, CT 06510, USA
    J Virol Methods 98:127-34. 2001
    Disease induced by Cottontail Rabbit Papilloma Virus (CRPV) scarification in domestic rabbits shares many attributes with disease induced by human papilloma virus (HPV)...
  79. ncbi Nitrocapsanthin and nitrofucoxanthin, respective products of capsanthin and fucoxanthin reaction with peroxynitrite
    Makoto Tsuboi
    Graduate of Science and Technology, Shizuoka University, 836 Ohya, Suruga ku, Shizuoka 422 8529, Japan
    J Agric Food Chem 59:10572-8. 2011
    ..Moreover, nitrocapsanthins (3 and 4) inhibited carcinogensis of mouse skin tumors initiated by 7,12-dimethylbenz[a]anthracene (DMBN)...
  80. ncbi Nasal cylindrical cell papilloma
    S T Subha
    Department of Surgery Otolaryngology, Faculty of Medicine and Health Sciences University Putra Malaysia, Hospital Kuala Lumpur, Jalan Masjid, 50586, Kuala Lumpur
    Med J Malaysia 60:103-5. 2005
    Inverted papilloma is the most common benign tumor of nose and paranasal sinuses arising from lateral nasal wall and middle meatus. Histologically these tumors are composed of epithelial nests that are inverted, exophytic and cylindrical...
  81. ncbi Mitomycin C in the treatment of a Schneiderian (inverted) papilloma of the lacrimal sac
    Malcolm Woodcock
    Birmingham and Midland Eye Centre, City Hospital, Dudley Road, Birmingham, West Midlands, B18 7QH, UK
    Int Ophthalmol 30:303-5. 2010
    Schneiderian papillomas are benign tumours, with an aggressive nature. A case with a recurrent Schneiderian papilloma of the nasolacrimal sac, who underwent an external dacryocystorhinostomy (DCR) with irrigation of the nasolacrimal ..
  82. ncbi E6 and E7 oncogene expression by human papilloma virus (HPV) and the aggressive behavior of recurrent laryngeal papillomatosis (RLP)
    Bahig M Shehata
    Department of Pathology, Children s Healthcare of Atlanta, 1405 Clifton Rd, Atlanta, GA 30322, USA
    Pediatr Dev Pathol 11:118-21. 2008
    Recurrent laryngeal papillomatosis (RLP), a chronic disease associated with human papilloma virus (HPV), requires serial surgical procedures for debulking, resulting in debilitating long-term dysphonia, laryngeal scarring, and rarely ..
  83. ncbi Long-term results of surgical treatment for recurrent respiratory papillomatosis
    Simon Florian Preuss
    Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Cologne, Josef Stelzmann Str 9, 50924 Cologne, Germany
    Acta Otolaryngol 127:1196-201. 2007
    ..A meticulous follow-up for early recognition of local recurrence and malignant transformation is recommended...
  84. ncbi HPV-induced recurrent laryngeal papillomatosis: dietary fatty acid and micronutrient intakes
    Louise Louw
    Department of Otorhinolaryngology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa
    Asia Pac J Clin Nutr 17:352-7. 2008
    Human papilloma virus (HPV)-induced recurrent laryngeal papillomatosis (RLP) is a chronic debilitating disease often encountered among children of poor socio-economic South African groups...
  85. ncbi Fine needle aspiration cytology of an intraductal papilloma originating in a sublingual gland. A case report
    H Hara
    Pathology Division, Yamanashi Prefectural Central Hospital, Japan
    Acta Cytol 43:457-63. 1999
    Intraductal papilloma of the salivary gland is a very rare tumor; only eight cases have been reported to date. Only histopathology has been used to investigate this tumor to our knowledge...
  86. ncbi Intracystic papilloma in the breast of a male given long-term phenothiazine therapy: a case report
    Hitoshi Yamamoto
    Department of Surgery, Minoh City Hospital, 5 7 1, Kayano, Osaka 562 8562, Japan
    Breast Cancer 13:84-8. 2006
    We experienced a very rare case of intracystic papilloma in a 57-year-old man who came to our hospital complaining of a left subareolar mass and nipple discharge...
  87. ncbi Squamous papilloma of the urinary tract is unrelated to condyloma acuminata
    L Cheng
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer 88:1679-86. 2000
    To the authors' knowledge, there is no previous report of squamous papilloma of the urinary tract. It is uncertain whether there is a correlation between squamous papilloma, condyloma acuminatum, and verrucous carcinoma.
  88. pmc Potential of diallyl sulfide bearing pH-sensitive liposomes in chemoprevention against DMBA-induced skin papilloma
    Arif Khan
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India
    Mol Med 13:443-51. 2007
    ..effects of liposomized DAS (conventional egg PC and pH-sensitive liposomes) against DMBA-induced skin papilloma. Various liposome-based novel formulations of DAS (250 microg/mouse) were applied topically, after one hour of ..
  89. ncbi Pro/antioxidant status and AP-1 transcription factor in murine skin following topical exposure to cumene hydroperoxide
    A R Murray
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV 26505, USA
    Carcinogenesis 28:1582-8. 2007
    ..No AP-1 expression was found 19 weeks after initiation. Papilloma formation was observed in both the DMBA-TPA- and DMBA-Cum-OOH-exposed animals, whereas skin carcinomas were ..
  90. ncbi Latent Human Papillomavirus infection is comparable in the larynx and trachea
    Allan L Abramson
    Department of Otolaryngology and Communicative Disorders, Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA
    J Med Virol 72:473-7. 2004
  91. ncbi Primary choroid plexus papilloma of the sellar region
    Yue hui Ma
    Department of Neurosurgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang Province, P R China
    J Neurooncol 88:51-5. 2008
    Choroid plexus papillomas are rare tumors of the central nervous system and are usually confined to the ventricle system. We describe a choroid plexus papilloma located in the sella turcica that was identified pathologically.
  92. pmc The neurofibromatosis type 1 (Nf1) tumor suppressor is a modifier of carcinogen-induced pigmentation and papilloma formation in C57BL/6 mice
    R P Atit
    Division of Molecular and Developmental Biology, Children s Hospital Research Foundation, Cincinnati, OH, USA
    J Invest Dermatol 114:1093-100. 2000
    ..The data support a plausible role for NF1 mutation in human epithelial carcinogenesis...
  93. pmc Immunohistochemical localization of human papilloma virus in conjunctival neoplasias: a retrospective study
    Seema Sen
    Ocular Pathology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India
    Indian J Ophthalmol 55:361-3. 2007
    The extent of association of human papilloma virus (HPV) in human conjunctival neoplasias has been debated in studies originating from different parts of the world, but no substantial evidence has been generated on Indian subjects...
  94. ncbi Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression
    Sarah M Allen
    Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Cancer Res 63:567-72. 2003
    ..DMBA) and phorbol 12-myristate 13-acetate (PMA)] application, is a multistep process involving papilloma formation and progression to carcinoma...
  95. ncbi The expression of P53 protein and infection of human papilloma virus in conjunctival and eyelid neoplasms
    Joanna Reszec
    Department of Pathology, Medical University of Bialystok, Waszyngtona 13, 15 269 Bialystok, Poland
    Int J Mol Med 16:559-64. 2005
    Human papilloma virus (HPV) infection and loss of P53 function have been identified as frequent events in various human tumors...
  96. ncbi Cytological findings of mixed squamous cell and glandular papilloma in the lung
    Kyuichi Kadota
    Department of Diagnostic Pathology, University Hospital, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Diagn Cytopathol 38:913-7. 2010
    Pulmonary mixed squamous cell and glandular papilloma is an extremely rare neoplasm. This is the first cytological report of such a rare neoplasm...
  97. ncbi Adult intralesional cidofovir therapy for laryngeal papilloma: a 10-year perspective
    Neil Tanna
    Voice Treatment Center and Division of Otolaryngology, The George Washington University, 2150 Pennsylvania Ave NW, Ste 6 301, Washington, DC 20037, USA
    Arch Otolaryngol Head Neck Surg 134:497-500. 2008
    To assess the long-term efficacy of intralesional cidofovir therapy in a previously reported cohort of adult subjects with laryngeal papilloma.
  98. ncbi Benign papilloma on core biopsy requires surgical excision
    Anita Rohini Skandarajah
    Department of Surgery, Royal Melbourne Hospital, Grattan Street, Parkville 3050, Australia
    Ann Surg Oncol 15:2272-7. 2008
    ..Our aim was to assess whether surgical excision is required by targeting this concordant group in a large screen-detected population...
  99. pmc Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia
    Florence A Scholl
    Stanford University School of Medicine, Stanford, California 94305, USA
    Cancer Res 69:3772-8. 2009
    ..Mek1 allele, however, did not affect tumor development, indicating that one Mek1 allele is sufficient for normal papilloma formation...
  100. ncbi Intermediate-term and long-term results after treatment by cidofovir and excision in juvenile laryngeal papillomatosis
    Ana Nusa Naiman
    Department of Otolaryngology, Edouard Herriot Hospital, Lyon, France
    Ann Otol Rhinol Laryngol 115:667-72. 2006
    ..We assessed the intermediate-term and long-term efficacy of intralesional injection of cidofovir used with surgical excision in juvenile-onset recurrent respiratory papillomatosis...
  101. ncbi Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation
    Lisa M Shantz
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Carcinogenesis 23:657-64. 2002

Research Grants70

    Xiaojiang Chen; Fiscal Year: 2005
    DESCRIPTION: (Adapted from the Investigator's abstract): Papilloma viruses are DNA tumor viruses that infect higher vertebrates including humans...
  2. Nanopolymersomes for Transcutaneous Co-Delivery of Vaccine Antigens and Adjuvants
    PAUL CAMILLE TUMEH; Fiscal Year: 2013
    ..generate L1 capsid/IMQ NPSs and hypothesize that this vaccine will induce a protective immune response against papilloma development in a Cottontail Rabbit Papilloma Virus (CRPV) rabbit model...
  3. Moffitt Skin Cancer SPORE
    Jeffrey S Weber; Fiscal Year: 2013
    ..Project 4 will focus on Human Papilloma Virus (HPV) and Merkel's Cell Polyoma Virus (MCPV) types that could potentially play a key role in the ..
  4. RRSS #08: Evaluating Prevalence HPV Infection Among Head and Neck Cancer Patients
    Dennis M Deapen; Fiscal Year: 2009
    ..Human papilloma virus (HPV) has been proven to be an etiologic factor for cervical cancer...
  5. Antifibrotic Therapy to Improve Immune reconstitution in HIV
    Timothy W Schacker; Fiscal Year: 2013
    ..poor vaccine responsiveness, increased bacterial infections, and poor control of mucosal pathogens like human papilloma virus and herpes simplex virus...
  6. IL-15 Characterization Through Experimental Immunology
    Michael A Caligiuri; Fiscal Year: 2013
    ..The recent successful development of the vaccine preventing human papilloma virus infection illustrates the power and rewards of immunology research...
  7. Biomarkers to Guide Treatment and Improve Survival in Oral/Oropharyngeal Cancer
    Thomas E Carey; Fiscal Year: 2012
    ..DNA and RNA will also be harvested from these tissues. Biomarkers will include: High risk human papilloma virus type and copy number, p53 status and expression, BCLXL expression, the epidermal growth factor receptor (..
  8. 2nd ASM Conference on Manipulation of Nuclear Processes by DNA Viruses
    Laimonis A Laimins; Fiscal Year: 2011
    ..DNA viruses such as Polyoma-, Papilloma-, Adeno- and Herpesviruses interact with many of the same host cell pathways, however, each virus family has ..
  9. The interaction of Chlamydia with the host cytoskeleton
    Scott S Grieshaber; Fiscal Year: 2012
    ..Additionally, the link between cervical cancer and Chlamydia likely involves an interaction with human papilloma virus (HPV) infection...
  10. Develop an Oral HIV Vaccine Using Papilloma Virus-Like Particles as a Vector
    Liang Qiao; Fiscal Year: 2012
    ..Project Narrative: HIV infection causes AIDS, a serious global health problem. Currently there is no effective vaccine for HIV infection. This project is to develop a novel oral vaccine to treat and prevent HIV infection. ..
  11. Immunotherapeutic Potential of Modified Lipooligosaccharides and Lipid A's
    Robert K Ernst; Fiscal Year: 2013
    ..lipid A, MPL) adjuvant has been combined with alum (AS04) in two FDA-approved vaccines (Cervarix (Human Papilloma Virus), and Fendrix (Hepatitis B Virus))...
  12. Combinational Approaches to the Chemoprevention of Esophageal Cancer
    Tong Chen; Fiscal Year: 2012
    ..The multistage evolution of esophageal SCC, from normal to hyperplasia, dysplasia and papilloma, is ideal for the application of chemoprevention strategies...
  13. Etiologic Role of HPV in Keratinocyte Carcinomas
    Margaret Karagas; Fiscal Year: 2009
    Human papilloma viruses (HPVs) encompass the most common "carcinogenic" viruses. While an oncogenic role of HPVs has been established for anogenital cancers, an etiologic relationship for keratinocyte cancers (i.e...
  14. Deguelin in therapy of triple negative breast cancer
    Rajendra G Mehta; Fiscal Year: 2013
    ..inhibited development of precancerous lesions in mammary glands in organ cultures, inhibited development of papilloma in two-stage skin carcinogenesis, suppressed tumor multiplicity in MNU-induced mammary carcinogenesis and ..
  15. Exploring the Association Between Immune-Related Genetic Variation and HNSCC
    Chaya Levovitz; Fiscal Year: 2013
    ..While most HNSCC cases are associated with exposure to tobacco and alcohol or infection with the human papilloma virus (HPV), the majority of persons exposed do not develop cancer, suggesting genetic variation plays a role in ..
  16. Immunization Delivery in Obstetrics and Gynecology Settings
    Amanda F Dempsey; Fiscal Year: 2013
    ..import for younger women of reproductive age, tetanus-diphtheria-acellular pertussis vaccine (Tdap) and Human Papilloma Virus vaccine (HPV). Rates for these vaccines are also very low among adults...
  17. Mechanisms in Polyoma and Papillomavirus Assembly
    ROBERT GARCEA; Fiscal Year: 2013
    ..which have been specifically marked by a nonstructural viral protein such as the polyoma large T-antigen or papilloma E2 protein bound to the viral DNA...
  18. SAG E3 ubiquitin ligase in regulation of transformation and carcinogenesis
    Yi Sun; Fiscal Year: 2013
    ..or grown in nude mice, respectively;2) SAG transgenic expression accelerates the growth of DMBA/TPA-induced skin papilloma by inhibiting apoptosis;3) SAG is overexpressed in multiple human cancers, particularly lung cancer, and 4) SAG ..
  19. Genetic Susceptibility to Papilloma-induced Voice Disturbance
    FARREL JOEL BUCHINSKY; Fiscal Year: 2012
    ..Finally, all candidate genes identified by both a priori and a postori studies will be sequenced to identify those genetic lesions responsible for this life-changing disease. ..
  20. Molecular etiology of cervicovaginal adenosis by in utero hormone exposure
    Takeshi Kurita; Fiscal Year: 2013
    ..The cervical and vaginal CCACs are generally negative for human papilloma virus (HPV) infection, and their etiology is not understood...
  21. Anogenital HPV Infection in a Population-Based Sample of Puerto Rican Women
    Ana Patricia Ortiz; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Although genital human papilloma virus (HPV) infection is the most commonly diagnosed sexually transmitted infection among young sexually active populations worldwide, no epidemiological studies of ..
  22. Patterns of Somatic Gene Alterations in Oral Cancer
    KARL TIMOTHY KELSEY; Fiscal Year: 2012
    ..Alcohol use and tobacco smoking act synergistically in causing this disease, although exposure to the human papilloma virus (HPV) is now also linked to HNSCC risk...
  23. Human Papilloma Virus Infection in Patients with Colorectal Cancer
    MARCIA ROXANA CRUZ-CORREA; Fiscal Year: 2013
    ..Identification of HPV as an etiologic factor in CRC carcinogenesis may impact current molecular models, prevention strategies and treatment algorithms. ..
  24. Applications of Core-Shell Ti02 Nanoconjugates
    Gayle E Woloschak; Fiscal Year: 2013 propose to combine these approaches and the rabbit liver carcinoma VX2 model, a cancer that develops due to papilloma virus infection, in order to attempt to use nanoconjugates therapeutically...
  25. The Role of C/EBPa in Genome Stability and Tumor Progression
    JONATHAN RUSSELL HALL; Fiscal Year: 2012
    ..These mice are highly susceptible to UVB- and carcinogen-induced squamous papilloma development and these benign skin tumors display a highly accelerated rate of malignant progression to squamous ..
    Ganes C Sen; Fiscal Year: 2013
    ..In the second aim we will determine the mechanism of inhibition of human papilloma virus (HPV) replication by human P56, the product of ISG56...
  27. Keratinocyte responses to vascular endothelial growth factor in carcinogenesis
    Traci A Wilgus; Fiscal Year: 2012
    ..In the skin, high VEGF levels are associated with enhanced papilloma development, increased squamous cell carcinoma numbers, and a higher incidence of lymph node metastasis...
  28. Using Maternal Cancer Screening Visits to Improve Adolescent HPV Vaccination
    Ruth C Carlos; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): In 2006, the FDA approved the first human papilloma virus (HPV) vaccine with the Centers for Disease Control and Prevention (CDC) Advisory Committee on Immunization Practices (ACIP) subsequently ..
  29. HPV vaccine practices among Physicians Serving High Risk, Minority Populations
    Abraham Aragones; Fiscal Year: 2010
    ..Almost all cervical cancers are caused by the human papilloma virus (HPV), and it is estimated that 6.2 million persons are newly infected every year...
  30. Broad Spectrum Antiviral Nucleoside Phosphonate Analogs
    John M Hilfinger; Fiscal Year: 2013 a potential bioterrorism threat, and numerous other DNA viruses, including herpes, adeno, pox, polyoma and papilloma viruses, are of general concern in a public health context, as are the possible emergence of new pathogens and ..
  31. The Molecular Biology of DNA Tumor Viruses Conference
    Paul F Lambert; Fiscal Year: 2013 the annual international conference for scientists studying the molecular biology of adeno, polyoma/SV40, and papilloma viruses...
  32. A Blueprint for Oncogenic Epigenetic Reprogramming
    SIAVASH KURDISTANI; Fiscal Year: 2009
    ..Viral oncoproteins such as the Adenovirus small e1a or Papilloma virus E7 have been extraordinarily useful in delineating the central molecular players that regulate cell ..
  33. The role of signal transduction cascades in mediating papillomavirus infection.
    CYNTHIA YVONNE ABBAN; Fiscal Year: 2012
    ..The human papilloma virus infects the cells lining the cervix and anus by binding to the cells, entering them, using their machinery ..
  34. Human Papillomavirus Infection and Expression of COX-2
    Bettie M Steinberg; Fiscal Year: 2013
    ..There is currently no therapy that will prevent recurrence. Papilloma cells have multiple alterations in signal transduction pathways associated with the EGF receptor, which result ..
  35. Hypoxia Image-Guided Radiation Therapy
    Nancy Y Lee; Fiscal Year: 2013
    ..Although the recent focus on biomarkers for HNSCC has been on the human papilloma virus (HPV) status, additional efforts in improving the efficacy of individualized therapy have lead to the ..
    WARREN DOUGLAS JOHNSON; Fiscal Year: 2012
    ..and maternal-infant transmission research;4) HIV- associated opportunistic infections - tuberculosis and human papilloma virus infection (HPV); 5) ethics and behavioral research, with an emphasis on adolescents;and 7) pathogenesis, ..
  37. MicroRNA Profiling and Tumor Progression in HPV+ Oropharyngeal Cancer
    Daniel L Miller; Fiscal Year: 2013
    ..have revealed that 40-80% of oropharyngeal squamous cell carcinomas (OPSCC) diagnosed in the US contain human papilloma virus (HPV). The incidence of OPSCC has increased significantly at a rate of 1.3% and 0...
  38. HPV-Specific, Immune Suppression in Patients with RRP
    VINCENT ROBERT BONAGURA; Fiscal Year: 2013
    ..response to HPV? These HPVs induce extremely high levels of the pro-inflammatory cytokine IL-36[unreadable] in papilloma tissues, which paradoxically fails to trigger an effective activating innate response and the subsequent immune ..
  39. The Effect of Economic Conditions and Social Capital on the Use of Clinical Preve
    Bisma A Sayed; Fiscal Year: 2013
    ..we will examine the following CPS utilization outcomes for each specific aim: vaccinations (influenza and human papilloma (HPV)) and health screenings (prostate cancer, colorectal cancer, cervical cancer, and breast cancer)...
  40. Mechanistic analysis of transport through the mucus barrier
    Katharina Ribbeck; Fiscal Year: 2013
    ..their tremendous implications for drug delivery and preventing prevalent infectious diseases (for example Papilloma virus, HIV)...
  41. Real-time detection and identification of single viruses
    Lukas Novotny; Fiscal Year: 2011
    ..The detector will be tested and characterized with intact viruses (Parainfluenza, Papilloma, Herpes Simplex, Vaccinia, Influenza X31, Sindbis (alpha), Adeno, HIV) supplied by collaborators...
  42. Molecular Targeting Strategies in HNSCC
    Daniel E Johnson; Fiscal Year: 2013
    ..The incidence of human papilloma virus (HPV)- associated HNSCC is increasing and represents an emerging health problem...
  43. PDZ-targeted Therapeutics for Cervical Cancer
    MICHAEL PAUL BELMARES; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Oncogenic variants of human papilloma virus (HPV) have been correlated with cervical cancer at a frequency of >99%, and also cause penile, anal and head and neck cancers...
  44. The Role of Rac1 in HPV-induced Recurrent Respiratory Papillomatosis
    ALEXANDRA VITKO LUCS; Fiscal Year: 2012 used to identify which pathway(s) downstream of Rac1 contribute to enhanced HPV expression in immortalized papilloma cells...
  45. Mechanisms of mucosal protection by HPV-SIV and gp96-lg-SIV vaccines
    Eckhard R Podack; Fiscal Year: 2011
    ..The two vaccine strategies are based on human papilloma virus delivering SIV-cDNAs, designated HPV-SIV, and on HEK293-cells secreting immunogenic chaperone-gp96- Ig-SIV-..
    DAVID MORSE LIVINGSTON; Fiscal Year: 2013
    Papovaviruses are DNA viruses with very small genomes;yet they are both transforming and tumorigenic. The human Papilloma viruses are well-established malignant tumor-generating agents in man...
  47. California Emerging Infections Program Capacity Building, Influenza Testing and B
    Duc Vugia; Fiscal Year: 2011
    ..influenza, healthcare- associated infections, foodborne illnesses, reproductive tract lesions caused by human papilloma virus, and numerous other infectious diseases is used to establish burden of disease;make national projections;..
  48. Programs in HIV and AIDS-Associated Diseases/Malignancies
    Charles Wood; Fiscal Year: 2013 the University of Nebraska and the University of Miami in: 1) basic research on the role of HIV, human papilloma virus (HPV), Kaposi's sarcoma-associated herpesvirus (KSHV), and Epstein Barr virus (EBV) in the ..
  49. African Collaborative Center for Microbiome and Genomics Research (ACCME)
    CLEMENT ADEBAYO ADEBAMOWO; Fiscal Year: 2013 study the interaction between vaginal microbiome, host genetic factors and molecular variants of Human Papilloma Virus (HPV) to determine correlates of viral persistence in the causal pathway of cervical cancer, a major cause ..
  50. Targeting HPV E6-Dependent Hypoxia-Induced NF-kappa B in Cervical Cancer
    Matthew B Rettig; Fiscal Year: 2013
    ..ABSTRACT Cervical cancer is the leading cause of cancer-specific mortality amongst women worldwide and the human papilloma virus (HPV) plays a pathophysiologic role in cervical carcinogenesis in over 95% of cases...
    Richard Kahn; Fiscal Year: 2002
    ..g., herpes, papilloma, and HIV. The development of toxin based adjuvants has been limited by the toxicity of the toxins alone...
  52. Markers and therapeutic strategies for overcoming chemoradiotherapy resistance
    John V Heymach; Fiscal Year: 2013
    ..Furthermore, human papilloma virus (HPV) was identified as a strong prognostic marker in HNSCC patients treated with CRT...
  53. Detection of Human Papilloma Virus in Cortical Dysplasia
    Peter B Crino; Fiscal Year: 2013
    ..These experiments would demonstrate for the first time HPV infection in the human brain and would thus open doors to many new avenues for investigation. ..
  54. Aluminum Oxide Nanoparticles Conjugated to Antigens Potently Induce Tumor Specifi
    TRACI LEIGH HILTON; Fiscal Year: 2013 applicant): PROJECT SUMMARY Although prophylactic vaccines have potential for prevention of high risk human papilloma virus (HPV) infection they have no therapeutic efficacy...
  55. Epigenetic Biomarker Discovery in HPV related HNSCC
    Joseph A Califano; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): High risk human papilloma virus related head and neck squamous cell carcinoma (HPVHNSCC) incidence is rapidly increasing, and will soon surpass the incidence of cervical carcinoma in the US...
  56. Osteopontin and microenvironment of initiated cells
    Pi Ling Chang; Fiscal Year: 2010
    ..Our in vivo endpoint of this transforming process is the papilloma, which is readily measured...
  57. Evaluation of vaccination reminder/recall systems for adolescent patients
    Peter Szilagyi; Fiscal Year: 2009
    ..Most adolescents >11 years are now eligible to receive newly licensed adolescent vaccinations including human papilloma virus (HPV), meningococcal vaccine and tetanus-pertussis vaccine (TdaP)...
  58. Can Chlamydial Infection Increase Host Mutation Frequency?
    ROBERT SCHOBORG; Fiscal Year: 2009
    ..trachomatis genital infection has been linked to cervical cancer, either directly or as a co-factor with Human Papilloma Virus (HPV). Other chlamydial infections have also been recently linked to various cancers: C...
    Cheryl Rock; Fiscal Year: 1999
    ..determine if the regression of CIN I and ll is reflected in the modulation of viral genome copy number of human papilloma virus (HPV) and HPV E6/E7 expression; and to determine if the regression of CIN I and II is associated with ..
    Roger Strair; Fiscal Year: 1993
    ..The transforming genes of a broad spectrum of viruses including adenoviruses. SV40, papilloma viruses and HTLV-I encode a transcriptional transactivator...
  61. Diindolylmethane enhances the efficacy of preventive vaccines in an HPV transgeni
    DANIEL WAYNE SEPKOVIC; Fiscal Year: 2013
    Project Summary/Abstract The Human Papilloma Virus (HPV) is recognized as the major cause of cervical cancer...
  62. Role of Wnt signaling in Cervical Cancer Pathogenesis
    Aykut Uren; Fiscal Year: 2010
    Cervical carcinoma, the second-leading cause of cancer deaths in women worldwide, is associated with human papilloma virus (HPV)...
  63. DNA-Based Lateral Flow Assay for Oncogenic Strains of HPV
    LEONARD BAZAR; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Human Papilloma Virus (HPV) comprises a family of viruses of over 100 different strains...
  64. Allogeneic Stem Cell Transplants for HPV+Cervical Cancer
    Alexander Fefer; Fiscal Year: 2003
    ..We have selected Human Papilloma Virus (HPV)-associated cervical cancer as a model because it constitutively expresses HPV genes E6/E7, which are ..
    Daniel Donoghue; Fiscal Year: 2001
    ..This proposal examines structural aspects of the E5 oncoprotein of bovine papilloma virus (BPV), which mimics PDGF and activates PDGF receptors during autocrine transformation...
    Rocky Tuan; Fiscal Year: 1999
    ..growth-related enzyme ornithine decarboxylase (ODC) causes cellular transformation and is central to TPA-induced papilloma formation in mouse skin...
  67. VSV-based Therapeutic Papilloma Vaccine
    Janet Brandsma; Fiscal Year: 2007
    ..therapeutic outcomes including the complete and permanent regression of all disease in some rabbits with a total papilloma burden of 4 cm3, as compared to no regression in the controls...
  68. Enhanced Single-Visit Cervical Cancer Screening Program
    Hoda Anton Culver; Fiscal Year: 2007
    ..and evaluate a process to identify women in local Latino/Hispanic communities who have oncogenic type human Papilloma virus (HPV) infections, known precursors for cervix dysplasia and cervical cancer, and recruit them for the SVP...
    EDWARD FEY; Fiscal Year: 1992
    ..The recent correlation of human papilloma virus (HPV) types 16 and 18 with cervical carcinoma has added to the difficulty of making correct prognoses from ..
    Arthur Schwartz; Fiscal Year: 1993
    ..the above side effects and also show enhanced tumor chemopreventive activity in mice in the two-stage skin papilloma system...