neuroblastoma

Summary

Summary: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Top Publications

  1. pmc A novel and universal method for microRNA RT-qPCR data normalization
    Pieter Mestdagh
    Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    Genome Biol 10:R64. 2009
  2. pmc A distinct "side population" of cells with high drug efflux capacity in human tumor cells
    C Hirschmann-Jax
    Center for Cell and Gene Therapy, Baylor College of Medicine, Methodist Hospital and Texas Children s Hospital, and DeBakey Department of Surgery, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:14228-33. 2004
  3. doi Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
    Isabelle Janoueix-Lerosey
    Institut Curie, Centre de Recherche, and INSERM, U830, 26 Rue d Ulm, Paris F 75248, France
    Nature 455:967-70. 2008
  4. doi Oncogenic mutations of ALK kinase in neuroblastoma
    Yuyan Chen
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Nature 455:971-4. 2008
  5. pmc Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma
    Alice L Yu
    University of California, San Diego, and Moores Cancer Center, San Diego, CA 92103 8447, USA
    N Engl J Med 363:1324-34. 2010
  6. pmc The genetic landscape of high-risk neuroblastoma
    Trevor J Pugh
    The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Nat Genet 45:279-84. 2013
  7. doi Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research
    Yuen Ting Cheung
    Laboratory of Neurodegenerative Diseases, Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Neurotoxicology 30:127-35. 2009
  8. pmc Identification of ALK as a major familial neuroblastoma predisposition gene
    Yael P Mosse
    Division of Oncology and Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nature 455:930-5. 2008
  9. ncbi MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells
    C Welch
    Children s Cancer Research Institute and Department of Pediatrics, The University of Texas Health Science Center at San Antonio, MC 7784, TX, USA
    Oncogene 26:5017-22. 2007
  10. pmc Identification of epigenetically regulated genes that predict patient outcome in neuroblastoma
    Helena Caren
    Department of Clinical Genetics, Institute of Biomedicine, University of Gothenburg, Sahlgrenska University Hospital, SE 41345 Gothenburg, Sweden
    BMC Cancer 11:66. 2011

Research Grants

  1. Neil W Kowall; Fiscal Year: 2014
  2. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
  3. Vickram Ramkumar; Fiscal Year: 2016
  4. EFFECT OF DRUGS OF ABUSE ON NEURONAL REDOX AND METHYLATION STATUS
    Richard C Deth; Fiscal Year: 2012
  5. Thyroid hormone-dependent DNA methylation in the developing brain
    Yasuhiro Kyono; Fiscal Year: 2012
  6. Genetic Susceptibility Factors in the Etiology of Neuroblastoma
    Andrew Olshan; Fiscal Year: 2012
  7. The Role of DNMT3B in the DNA Methylation of Cancer Cells
    LUCY ANN GODLEY; Fiscal Year: 2012
  8. Oxaloacetate's Brain Effects
    Russell H Swerdlow; Fiscal Year: 2013
  9. Yves A DeClerck; Fiscal Year: 2016
  10. Role of Parkin in Regulating Manganese Toxicity
    JEROME ALLAN ROTH; Fiscal Year: 2010

Detail Information

Publications362 found, 100 shown here

  1. pmc A novel and universal method for microRNA RT-qPCR data normalization
    Pieter Mestdagh
    Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    Genome Biol 10:R64. 2009
    ..We demonstrate that the mean expression value outperforms the current normalization strategy in terms of better reduction of technical variation and more accurate appreciation of biological changes...
  2. pmc A distinct "side population" of cells with high drug efflux capacity in human tumor cells
    C Hirschmann-Jax
    Center for Cell and Gene Therapy, Baylor College of Medicine, Methodist Hospital and Texas Children s Hospital, and DeBakey Department of Surgery, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:14228-33. 2004
    ..We initially examined primary tumor cells from 23 patients with neuroblastoma and cell lines derived from a range of other tumors...
  3. doi Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
    Isabelle Janoueix-Lerosey
    Institut Curie, Centre de Recherche, and INSERM, U830, 26 Rue d Ulm, Paris F 75248, France
    Nature 455:967-70. 2008
    b>Neuroblastoma, a tumour derived from the peripheral sympathetic nervous system, is one of the most frequent solid tumours in childhood...
  4. doi Oncogenic mutations of ALK kinase in neuroblastoma
    Yuyan Chen
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Nature 455:971-4. 2008
    b>Neuroblastoma in advanced stages is one of the most intractable paediatric cancers, even with recent therapeutic advances...
  5. pmc Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma
    Alice L Yu
    University of California, San Diego, and Moores Cancer Center, San Diego, CA 92103 8447, USA
    N Engl J Med 363:1324-34. 2010
    ..18, a monoclonal antibody against the tumor-associated disialoganglioside GD2, has activity against neuroblastoma and that such activity is enhanced when ch14...
  6. pmc The genetic landscape of high-risk neuroblastoma
    Trevor J Pugh
    The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Nat Genet 45:279-84. 2013
    b>Neuroblastoma is a malignancy of the developing sympathetic nervous system that often presents with widespread metastatic disease, resulting in survival rates of less than 50%...
  7. doi Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research
    Yuen Ting Cheung
    Laboratory of Neurodegenerative Diseases, Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Neurotoxicology 30:127-35. 2009
    Human neuroblastoma SH-SY5Y is a dopaminergic neuronal cell line which has been used as an in vitro model for neurotoxicity experiments...
  8. pmc Identification of ALK as a major familial neuroblastoma predisposition gene
    Yael P Mosse
    Division of Oncology and Center for Childhood Cancer Research, Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nature 455:930-5. 2008
    b>Neuroblastoma is a childhood cancer that can be inherited, but the genetic aetiology is largely unknown...
  9. ncbi MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells
    C Welch
    Children s Cancer Research Institute and Department of Pediatrics, The University of Texas Health Science Center at San Antonio, MC 7784, TX, USA
    Oncogene 26:5017-22. 2007
    b>Neuroblastoma (NB) is one of the most common forms of cancer in children, accounting for 15% of pediatric cancer deaths...
  10. pmc Identification of epigenetically regulated genes that predict patient outcome in neuroblastoma
    Helena Caren
    Department of Clinical Genetics, Institute of Biomedicine, University of Gothenburg, Sahlgrenska University Hospital, SE 41345 Gothenburg, Sweden
    BMC Cancer 11:66. 2011
    ..Epigenetic mechanisms such as DNA methylation and histone modifications are important regulators of gene expression and are frequently involved in silencing tumor suppressor genes...
  11. pmc Neuroblastoma: developmental biology, cancer genomics and immunotherapy
    Nai Kong V Cheung
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Nat Rev Cancer 13:397-411. 2013
    b>Neuroblastoma is a solid tumour that arises from the developing sympathetic nervous system. Over the past decade, our understanding of this disease has advanced tremendously...
  12. pmc The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report
    Susan L Cohn
    Department of Pediatrics, The University of Chicago, Chicago, IL 60637, USA
    J Clin Oncol 27:289-97. 2009
    Because current approaches to risk classification and treatment stratification for children with neuroblastoma (NB) vary greatly throughout the world, it is difficult to directly compare risk-based clinical trials...
  13. doi Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy
    Johannes H Schulte
    Department of Paediatric Oncology and Hematology, University Children s Hospital Essen, Germany
    Cancer Res 69:2065-71. 2009
    ..address the functional significance of the chromatin-modifying enzyme lysine-specific demethylase 1 (LSD1) in neuroblastoma. LSD1 expression correlated with adverse outcome and was inversely correlated with differentiation in ..
  14. pmc Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma
    Mark Sausen
    Ludwig Center for Cancer Genetics and Therapeutics, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    Nat Genet 45:12-7. 2013
    ..To determine the genetic basis for neuroblastoma, we performed whole-genome sequencing (6 cases), exome sequencing (16 cases), genome-wide rearrangement ..
  15. pmc Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastoma
    Johannes H Schulte
    University Children s Hospital Essen, Hufelandstr 55, 45122 Essen, Germany
    Nucleic Acids Res 38:5919-28. 2010
    ..b>Neuroblastoma(NB) is an embryonal tumor with highly variable clinical course...
  16. pmc The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastoma
    Pieter Mestdagh
    Center for Medical Genetics, Ghent University Hospital, B 9000 Ghent, Belgium
    Mol Cell 40:762-73. 2010
    ..spectrometry, we examined the effects of activation of the miR-17-92 cluster on global protein expression in neuroblastoma (NB) cells...
  17. pmc A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene
    Kristina A Cole
    Division of Oncology, Children s Hospital of Philadelphia, Abramson Pediatric Research Center 902A, 3615 Civic Center Boulevard, Philadelphia, PA 19104 4318, USA
    Mol Cancer Res 6:735-42. 2008
    ..integrated genomics and functional screening strategy to identify potential oncomirs in the pediatric neoplasm neuroblastoma. We first identified microRNAs that map within chromosomal regions that we and others have defined as ..
  18. pmc Targeted expression of MYCN causes neuroblastoma in transgenic mice
    W A Weiss
    G W Hooper Foundation, and Department of Neurology, University of California, San Francisco 94143 0552, USA
    EMBO J 16:2985-95. 1997
    ..We have created transgenic mice that overexpress MYCN in neuroectodermal cells and develop neuroblastoma. Analysis of tumors by comparative genomic hybridization revealed gains and losses of at least seven ..
  19. pmc Activated ALK collaborates with MYCN in neuroblastoma pathogenesis
    Shizhen Zhu
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 21:362-73. 2012
    Amplification of the MYCN oncogene in childhood neuroblastoma is often accompanied by mutational activation of ALK (anaplastic lymphoma kinase), suggesting their pathogenic cooperation...
  20. ncbi Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
    M Kaghad
    Sanofi Recherche, Labege, France
    Cell 90:809-19. 1997
    ..p73 maps to 1p36, a region frequently deleted in neuroblastoma and other tumors and thought to contain multiple tumor suppressor genes...
  21. ncbi Inhibition of paraquat-induced autophagy accelerates the apoptotic cell death in neuroblastoma SH-SY5Y cells
    Rosa A Gonzalez-Polo
    CIBER de Enfermedades Neurodegenerativas, Departamento de Bioquimica y Biologia Molecular y Genetica, EU Enfermería y TO, Universidad de Extremadura, Avda Universidad s n 10071 Cáceres, Spain
    Toxicol Sci 97:448-58. 2007
    ..shows, for the first time, that low concentrations of PQ induce several characteristics of autophagy in human neuroblastoma SH-SY5Y cells...
  22. pmc miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma
    Alexander Swarbrick
    Cancer Research Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    Nat Med 16:1134-40. 2010
    ..of stress and occurs in many human cancers; however, normal embryonic stem cells and some cancers such as neuroblastoma maintain wild-type human TP53 and mouse Trp53 (referred to collectively as p53 herein)...
  23. ncbi Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop
    K Ohashi
    Biological Institute, Graduate School of Science, Tohoku University, Sendai 980 8578, Japan
    J Biol Chem 275:3577-82. 2000
    ....
  24. doi Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles
    Sandrine Alais
    LaboRétro INSERM U758, Unité de Virologie Humaine, Ecole Normale Superieure de Lyon, 69364 Lyon Cedex 07, France
    Biol Cell 100:603-15. 2008
    ..With this aim, we initiated characterization of the prion agent and the pathways by which it can be propagated using the cellular model system neuroblastoma (N2a).
  25. doi Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma
    Tobias Otto
    Institute of Molecular Biology and Tumor Research, Marburg, Germany
    Cancer Cell 15:67-78. 2009
    In human neuroblastoma, amplification of the MYCN gene predicts poor prognosis and resistance to therapy...
  26. doi Targeting aberrant PI3K/Akt activation by PI103 restores sensitivity to TRAIL-induced apoptosis in neuroblastoma
    Daniela Opel
    University Children s Hospital, Ulm and Institute for Experimental Cancer Research in Pediatrics, Goethe University, Frankfurt, Germany
    Clin Cancer Res 17:3233-47. 2011
    Because we recently identified Akt activation as a novel poor prognostic indicator in neuroblastoma, we investigated whether phosphoinositide 3'-kinase (PI3K) inhibition sensitizes neuroblastoma cells for TRAIL-induced apoptosis.
  27. ncbi Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma
    Julie R Park
    Department of Pediatric Hematology Oncology, Children s Hospital and Medical Center, Seattle, Washington, USA
    Mol Ther 15:825-33. 2007
    Metastatic neuroblastoma is a poor-prognosis malignancy arising during childhood that overexpresses the L1-cell adhesion molecule (CD171)...
  28. pmc Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma
    Martin A Pule
    Center for Cell and Gene Therapy, Baylor College of Medicine and The Methodist Hospital and Texas Children s Hospital, Houston, Texas 77030, USA
    Nat Med 14:1264-70. 2008
    ..receptor directed to the diasialoganglioside GD2, a nonviral tumor-associated antigen expressed by human neuroblastoma cells...
  29. pmc Anaplastic lymphoma kinase: signalling in development and disease
    Ruth H Palmer
    Department of Molecular Biology, Umea University, Umea, Sweden
    Biochem J 420:345-61. 2009
    ..in NSCLC (non-small cell lung cancer), together with the identification of activating point mutations in neuroblastoma, have highlighted ALK as a significant player and target for drug development in cancer...
  30. pmc MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2
    Niamh H Foley
    Department of Cancer Genetics, Royal College of Surgeons in Ireland, York House, York Street, Dublin 2, Ireland
    Mol Cancer 9:83. 2010
    b>Neuroblastoma is a paediatric cancer of the sympathetic nervous system. The single most important genetic indicator of poor clinical outcome is amplification of the MYCN transcription factor...
  31. pmc Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas
    Frank Westermann
    Department of Tumor Genetics, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany
    Genome Biol 9:R150. 2008
    ..In this study, we asked whether distinct transcriptional MYCN or c-MYC activities are associated with specific neuroblastoma phenotypes.
  32. pmc Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
    Chrystal U Louis
    Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children s Hospital, Houston, TX, USA
    Blood 118:6050-6. 2011
    We generated MHC-independent chimeric antigen receptors (CARs) directed to the GD2 antigen expressed by neuroblastoma tumor cells and treated patients with this disease...
  33. doi Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo
    Malin Wickström
    Childhood Cancer Research Unit, Department of Women s and Children s Health, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 132:1516-24. 2013
    ..b>Neuroblastoma, an embryonal tumor of the sympathetic nervous system, was recently shown to express high levels of key ..
  34. pmc Combination therapy targeting the Chk1 and Wee1 kinases shows therapeutic efficacy in neuroblastoma
    Mike R Russell
    Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 73:776-84. 2013
    b>Neuroblastoma is uniquely sensitive to single-agent inhibition of the DNA damage checkpoint kinase Chk1, leading us to examine downstream effectors of this pathway and identify mitotic regulator Wee1 as an additional therapeutic target ..
  35. doi Cold atmospheric plasma for the ablative treatment of neuroblastoma
    Ryan M Walk
    Sheikh Zayed Institute for Pediatric Surgical Innovation at Children s National Medical Center, Washington, DC 20010, USA
    J Pediatr Surg 48:67-73. 2013
    ..We studied helium-based CAP's effect on neuroblastoma, both in-vitro and in an in-vivo murine model.
  36. pmc Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in Neuroblastoma and Pediatric Sarcomas In vitro and In vivo
    Shuang Yan
    Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, USA
    Oncotarget 4:433-45. 2013
    ..AZD1480 in pediatric malignancies using preclinical models of three highly malignant pediatric solid tumors: neuroblastoma (NB), rhabdomyosarcoma (RMS) and the Ewing Sarcoma Family Tumors (ESFT)...
  37. pmc Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma
    Julieann Rader
    Authors Affiliations Division of Oncology and Center for Childhood Cancer Research Division of Pathology, Children s Hospital of Philadelphia Department of Pediatrics Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania and Novartis Institutes for Biomedical Research, Cambridge, Massachusetts
    Clin Cancer Res 19:6173-82. 2013
    b>Neuroblastoma is a pediatric cancer that continues to exact significant morbidity and mortality...
  38. pmc Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma
    X X Tang
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    Proc Natl Acad Sci U S A 97:10936-41. 2000
    b>Neuroblastoma (NB) is a common pediatric tumor that exhibits a wide range of biological and clinical heterogeneity...
  39. ncbi Pathology and biology guidelines for resectable and unresectable neuroblastic tumors and bone marrow examination guidelines
    P F Ambros
    Children s Cancer Research Institute, St Anna Children s Hospital, Vienna, Austria
    Med Pediatr Oncol 37:492-504. 2001
    ..and molecular-genetic and immunologic markers presented in this paper were developed by the SIOP Europe Neuroblastoma Pathology and Biology and Bone Marrow Group...
  40. pmc Bmi-1 is essential for the tumorigenicity of neuroblastoma cells
    Hongjuan Cui
    Department of Biochemistry and Cancer Biology, Medical University of Ohio, 3035 Arlington Ave, Toledo, OH 43614, USA
    Am J Pathol 170:1370-8. 2007
    Activation of oncogenes underlies the pathogenesis of most human cancers. In neuroblastoma, amplification of the oncogene MYCN occurs in approximately 22% of cases and is associated with advanced stages of the disease and poor prognosis...
  41. ncbi Oncogenic cooperation between H-Twist and N-Myc overrides failsafe programs in cancer cells
    Sandrine Valsesia-Wittmann
    INSERM U590, Centre Leon Berard, Universite Claude Bernard Lyon 1, Lyon F 69008 France
    Cancer Cell 6:625-30. 2004
    N-Myc oncogene amplification is a frequent event in neuroblastoma and is strongly correlated with advanced disease stage and treatment failure...
  42. doi Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma
    Jan J Molenaar
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cancer Res 68:2599-609. 2008
    Genomic aberrations of Cyclin D1 (CCND1), CDK4, and CDK6 in neuroblastoma indicate that dysregulation of the G(1) entry checkpoint is an important cell cycle aberration in this pediatric tumor...
  43. doi MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumors
    P Mestdagh
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    Oncogene 29:1394-404. 2010
    Increased activity of MYC protein-family members is a common feature in many cancers. Using neuroblastoma as a tumor model, we established a microRNA (miRNA) signature for activated MYCN/c-MYC signaling in two independent primary ..
  44. pmc Enhancing the GLP-1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cells
    Yazhou Li
    Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurochem 113:1621-31. 2010
    ..of GLP-1 and associated underlying mechanisms, we over-expressed the GLP-1 receptor (GLP-1R) on human neuroblastoma SH-SY5Y cells to generate a neuronal culture system featuring enhanced GLP-1R signaling...
  45. pmc In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine
    Zhijie Li
    Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health, 10 Center Drive MSC 1928, Bldg 10 CRC 1 3940, Bethesda, MD 20892, USA
    J Natl Cancer Inst 102:758-70. 2010
    Activated AKT is a marker of decreased event-free or overall survival in neuroblastoma (NB) patients...
  46. pmc Anti-angiogenic SPARC peptides inhibit progression of neuroblastoma tumors
    Alexandre Chlenski
    Department of Pediatrics, University of Chicago, KCBD Rm 5100, Chicago, IL 60637, USA
    Mol Cancer 9:138. 2010
    New, more effective strategies are needed to treat highly aggressive neuroblastoma. Our laboratory has previously shown that full-length Secreted Protein Acidic and Rich in Cysteine (SPARC) and a SPARC peptide corresponding to the ..
  47. pmc MiRNA-335 suppresses neuroblastoma cell invasiveness by direct targeting of multiple genes from the non-canonical TGF-β signalling pathway
    Jennifer Lynch
    Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, York House, York Street, Dublin 2, Ireland
    Carcinogenesis 33:976-85. 2012
    ..myosin light chain (MLC) leading to a significant inhibition of the invasive and migratory potential of neuroblastoma cells...
  48. pmc Gastrin-releasing peptide receptor silencing suppresses the tumorigenesis and metastatic potential of neuroblastoma
    Jingbo Qiao
    Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555 0353, USA
    Proc Natl Acad Sci U S A 105:12891-6. 2008
    b>Neuroblastoma accounts for nearly 15% of all pediatric cancer-related deaths...
  49. pmc Comprehensive SNP array study of frequently used neuroblastoma cell lines; copy neutral loss of heterozygosity is common in the cell lines but uncommon in primary tumors
    Hanna Kryh
    Department of Clinical Genetics, The Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, SE 41345 Gothenburg, Sweden
    BMC Genomics 12:443. 2011
    ..These alterations is sometimes seen in tumors as a way to inactivate a tumor suppressor gene and have been found to be important in several types of cancer...
  50. ncbi Neuroblastoma: biological insights into a clinical enigma
    Garrett M Brodeur
    Division of Oncology, The Children s Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    Nat Rev Cancer 3:203-16. 2003
    b>Neuroblastoma is a tumour derived from primitive cells of the sympathetic nervous system and is the most common solid tumour in childhood...
  51. pmc The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma
    Teeara Berry
    Division of Clinical Studies, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Cancer Cell 22:117-30. 2012
    ..mutation is associated with intrinsic and acquired resistance to crizotinib and cosegregates with MYCN in neuroblastoma. In this study, we generated a mouse model overexpressing ALK(F1174L) in the neural crest...
  52. ncbi International neuroblastoma pathology classification for prognostic evaluation of patients with peripheral neuroblastic tumors: a report from the Children's Cancer Group
    H Shimada
    Department of Pathology and Laboratory Medicine, Childrens Hospital Los Angeles, Los Angeles, CA 91066, USA
    Cancer 92:2451-61. 2001
    BACKGROUND: The International Neuroblastoma Pathology Classification was established in 1999 for the prognostic evaluation of patients with neuroblastic tumors (NTs)...
  53. pmc High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma
    Erik Fredlund
    Center for Molecular Pathology, Department of Laboratory Medicine, CREATE Health, University Hospital MAS, Lund University, SE 205 02 Malmo, Sweden
    Proc Natl Acad Sci U S A 105:14094-9. 2008
    The childhood cancer neuroblastoma arises in the developing sympathetic nervous system and is a genotypically and phenotypically heterogeneous disease...
  54. pmc MicroRNA mediates DNA demethylation events triggered by retinoic acid during neuroblastoma cell differentiation
    Sudipto Das
    Department of Cancer Genetics, Royal College of Surgeons, Ireland
    Cancer Res 70:7874-81. 2010
    b>Neuroblastoma is an often fatal pediatric cancer arising from precursor cells of the sympathetic nervous system...
  55. pmc MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma
    Amanda Tivnan
    Department of Cancer Genetics, Royal College of Surgeons in Ireland, York House, York Street, Dublin 2, Ireland
    BMC Cancer 11:33. 2011
    b>Neuroblastoma is a paediatric cancer which originates from precursor cells of the sympathetic nervous system and accounts for 15% of childhood cancer mortalities...
  56. ncbi Bmi-1 regulates the differentiation and clonogenic self-renewal of I-type neuroblastoma cells in a concentration-dependent manner
    Hongjuan Cui
    Department of Biochemistry and Cancer Biology, Medical University of Ohio, Toledo, Ohio 43614, USA
    J Biol Chem 281:34696-704. 2006
    Human neuroblastoma I-type cells have been proposed as a population of malignant neural crest stem cells, based on their high tumorigenic potential, expression of stem cell markers, and ability to differentiate into cells of neural crest ..
  57. pmc ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma
    Michael D Hogarty
    Division of Oncology, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    Cancer Res 68:9735-45. 2008
    b>Neuroblastoma is a frequently lethal childhood tumor in which MYC gene deregulation, commonly as MYCN amplification, portends poor outcome. Identifying the requisite biopathways downstream of MYC may provide therapeutic opportunities...
  58. doi Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53
    Tom Van Maerken
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    J Natl Cancer Inst 101:1562-74. 2009
    ..Mutational inactivation of p53 is rare in neuroblastoma tumors at diagnosis and occurs in only a subset of multidrug-resistant neuroblastomas.
  59. ncbi SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson's disease
    Hong rong Xie
    Department of Neurology, The First Hospital, Jilin University, Changchun, China
    Chin Med J (Engl) 123:1086-92. 2010
    To evaluate the human neuroblastoma SH-SY5Y cell line as an in vitro model of dopaminergic (DAergic) neurons for Parkinson's disease (PD) research and to determine the effect of differentiation on this cell model.
  60. pmc microRNA signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastoma
    Ruey Jen Lin
    Graduate Institute of Life Science, National Defense Medical Center, and Genomics Research Center, Academia Sinica, Taipei, Taiwan
    Cancer Res 70:7841-50. 2010
    b>Neuroblastoma is a common childhood tumor and accounts for 15% of pediatric cancer deaths...
  61. pmc Integrative genomics identifies LMO1 as a neuroblastoma oncogene
    Kai Wang
    The Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Nature 469:216-20. 2011
    b>Neuroblastoma is a childhood cancer of the sympathetic nervous system that accounts for approximately 10% of all paediatric oncology deaths...
  62. doi Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma
    S G Lee
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA
    Oncogene 28:2476-84. 2009
    b>Neuroblastoma, derived from neural crest progenitor cells, is the most common extracranial solid tumor of childhood. Astrocyte elevated gene-1 (AEG-1) is a primary mediator of tumor progression and metastasis in several human cancers...
  63. ncbi Molecular biology of neuroblastoma
    J M Maris
    Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Clin Oncol 17:2264-79. 1999
    PURPOSE AND RESULTS: Neuroblastoma, the most common solid extracranial neoplasm in children, is remarkable for its clinical heterogeneity. Complex patterns of genetic abnormalities interact to determine the clinical phenotype...
  64. ncbi Integrative genomics identifies distinct molecular classes of neuroblastoma and shows that multiple genes are targeted by regional alterations in DNA copy number
    Qun Wang
    Division of Oncology, Children s Hospital of Philadelphia, PA 19104 4399, USA
    Cancer Res 66:6050-62. 2006
    b>Neuroblastoma is remarkable for its clinical heterogeneity and is characterized by genomic alterations that are strongly correlated with tumor behavior...
  65. ncbi FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells
    P Obexer
    Tyrolean Cancer Research Institute, Innsbruck, Austria
    Cell Death Differ 14:534-47. 2007
    ..We analyzed human neuroblastoma cells and found that FKHRL1 was phosphorylated, suggesting its inactivation...
  66. ncbi The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma
    Jun Fang
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Pharmacol 70:2108-15. 2006
    ..We found elevated MCT1 mRNA levels in fresh neuroblastoma biopsy samples that correlated positively with risk of fatal disease and amplification of the "proto-..
  67. ncbi Activation of Akt predicts poor outcome in neuroblastoma
    Daniela Opel
    University Children s Hospital, Ulm, Germany
    Cancer Res 67:735-45. 2007
    ..cascade, has previously been linked to poor prognosis in several human malignancies, its prognostic effect in neuroblastoma has not yet been explored...
  68. doi Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
    Ultan McDermott
    Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA
    Cancer Res 68:3389-95. 2008
    ..These findings suggest that a subset of lung cancers, lymphomas, and neuroblastomas that harbor genomic ALK alterations may be clinically responsive to pharmacologic ALK inhibition...
  69. ncbi A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: a Children's Oncology Group study
    Mason Bond
    B C Children s Hospital, Vancouver, British Columbia, Canada
    Pediatr Blood Cancer 50:254-8. 2008
    ..It also inhibits KIT and PDGF receptor tyrosine kinases in vitro. Ewing sarcoma, osteosarcoma, neuroblastoma, desmoplastic small round cell, and synovial sarcomas often overexpress KIT or the PDGF receptor...
  70. doi Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells
    Mordhwaj S Parihar
    School of Studies in Biotechnology and Zoology, Vikram University, Ujjain, MP, India
    Int J Biochem Cell Biol 41:2015-24. 2009
    ..The present study shows that overexpression of alpha-synuclein A53T or A30P mutants or wild-type in human neuroblastoma cells augmented aggregation of alpha-synuclein...
  71. pmc The MYCN oncogene is a direct target of miR-34a
    J S Wei
    Oncogenomics Section, Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute, Gaithersburg, MD 20892, USA
    Oncogene 27:5204-13. 2008
    Loss of 1p36 heterozygosity commonly occurs with MYCN amplification in neuroblastoma tumors, and both are associated with an aggressive phenotype...
  72. pmc Activating mutations in ALK provide a therapeutic target in neuroblastoma
    Rani E George
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 455:975-8. 2008
    b>Neuroblastoma, an embryonal tumour of the peripheral sympathetic nervous system, accounts for approximately 15% of all deaths due to childhood cancer...
  73. ncbi Identification of miRNAs that are associated with tumor metastasis in neuroblastoma
    Jigang Guo
    Jiangsu Diabetes Center, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China
    Cancer Biol Ther 9:446-52. 2010
    ..However, the miRNA expression profile in neuroblastoma (NB), one of the most common cancer forms in children, has not been well characterized...
  74. doi Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors
    M B Nilsson
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 29:2938-49. 2010
    Novel treatment approaches are needed for children with advanced neuroblastoma. Studies with neuroblastoma cells have indicated the presence of a hypoxia-driven vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)-1 autocrine ..
  75. doi Visualization of co-localization in Aβ42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death
    Violetta Soura
    School of Life Sciences, University of Sussex, Falmer, BN1 9QG, UK
    Biochem J 441:579-90. 2012
    ..In the present study we show that administration of freshly prepared Aβ42 oligomers to a neuroblastoma (SH-SY5Y) cell line results in a reduction in survival, and that Aβ42 enters the cells prior to cell death...
  76. doi Children's Oncology Group's 2013 blueprint for research: neuroblastoma
    Julie R Park
    Seattle Children s Hospital, University of Washington School of Medicine and Fred Hutchinson Cancer Research Center, Seattle, WA 98106, USA
    Pediatr Blood Cancer 60:985-93. 2013
    Estimated 5-year survival rates for patients with non-high-risk and high-risk neuroblastoma are 90% and 50%, respectively. Recent clinical trials have shown excellent outcomes with reduced therapy for non-high-risk disease...
  77. pmc Targeting MYCN in neuroblastoma by BET bromodomain inhibition
    Alexandre Puissant
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Cancer Discov 3:308-23. 2013
    ..We characterized the mechanistic and translational significance of this finding in neuroblastoma, a childhood cancer with frequent amplification of MYCN...
  78. pmc Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma
    H Kocak
    Children s Hospital, Department of Pediatric Oncology and Hematology and Center for Molecular Medicine Cologne CMMC, University of Cologne, Cologne, Germany
    Cell Death Dis 4:e586. 2013
    b>Neuroblastoma is an embryonal malignancy of the sympathetic nervous system...
  79. doi Current and future strategies for relapsed neuroblastoma: challenges on the road to precision therapy
    Daniel A Morgenstern
    Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
    J Pediatr Hematol Oncol 35:337-47. 2013
    More than half of the patients with high-risk neuroblastoma (NB) will relapse despite intensive multimodal therapy, with an additional 10% to 20% refractory to induction chemotherapy...
  80. pmc Proteome profiling of neuroblastoma-derived exosomes reveal the expression of proteins potentially involved in tumor progression
    Danilo Marimpietri
    Laboratory of Oncology, Department of Translational Research and Laboratory Medicine, Istituto Giannina Gaslini, Genoa, Italy
    PLoS ONE 8:e75054. 2013
    b>Neuroblastoma (NB) is the most common extracranial solid tumor in childhood, with grim prognosis in a half of patients...
  81. pmc USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis
    Y H Fan
    Texas Children s Cancer Center, Department of Pediatrics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Death Dis 4:e867. 2013
    b>Neuroblastoma (NB) is a common pediatric cancer and contributes to more than 15% of all pediatric cancer-related deaths...
  82. doi NF-kappaB, and not MYCN, regulates MHC class I and endoplasmic reticulum aminopeptidases in human neuroblastoma cells
    Matteo Forloni
    Research Center, Ospedale Bambino Gesu, Rome, Italy
    Cancer Res 70:916-24. 2010
    b>Neuroblastoma (NB) is the most common solid extracranial cancer of childhood...
  83. pmc Chromosomal and microRNA expression patterns reveal biologically distinct subgroups of 11q- neuroblastoma
    Patrick G Buckley
    Department of Cancer Genetics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Clin Cancer Res 16:2971-8. 2010
    The purpose of this study was to further define the biology of the 11q- neuroblastoma tumor subgroup by the integration of array-based comparative genomic hybridization with microRNA (miRNA) expression profiling data to determine if ..
  84. doi Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation
    Laura del Barrio
    Instituto Teofilo Hernando, Facultad de Medicina, Universidad Auto noma de Madrid, 28029 Madrid, Spain
    Toxicol Sci 123:193-205. 2011
    ..Therefore, targeting nAChR could offer a strategy for reducing neurodegeneration secondary to hyperphosphorylation of protein τ...
  85. pmc Crosstalk between MYCN and MDM2-p53 signal pathways regulates tumor cell growth and apoptosis in neuroblastoma
    Jing He
    Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service, Emory University School of Medicine, Atlanta, GA, USA
    Cell Cycle 10:2994-3002. 2011
    ..Herein, we report that the interaction between MDM2 and MYCN plays a critical role in MYCN-amplified neuroblastoma tumor cell growth and survival...
  86. doi Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR
    Tsui Chin Huang
    Department of Life Science, National Taiwan University, Taipei, Taiwan
    FEBS Lett 585:3582-6. 2011
    b>Neuroblastoma is the most common extracranial solid tumor in children. We investigate whether miR-124, the abundant neuronal miRNA, plays a pivotal role in neuroblastoma...
  87. doi Apoptosis induction by different local anaesthetics in a neuroblastoma cell line
    R Werdehausen
    Department of Anaesthesiology, University of Dusseldorf, Dusseldorf, Germany
    Br J Anaesth 103:711-8. 2009
    ..Hitherto, it is unknown what determines the apoptotic potency of local anaesthetics. Therefore, we compared apoptosis induction by local anaesthetics related to their physicochemical properties in human neuronal cells...
  88. pmc TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells
    G M Marshall
    Children s Cancer Institute Australia for Medical Research, Randwick, New South Wales, Australia
    Oncogene 29:6172-83. 2010
    ..In this study, we show that overexpressed TRIM16 reduced neuroblastoma cell growth, enhanced retinoid-induced differentiation and reduced tumourigenicity in vivo...
  89. pmc Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity
    Kristopher R Bosse
    Division of Oncology and Center for Childhood Cancer Research, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 72:2068-78. 2012
    ..In this study, we characterized the high-risk neuroblastoma association at the BRCA1-related locus, BARD1, showing that disease-associated variations correlate with ..
  90. pmc Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma
    Eugene S Kim
    Division of Pediatric Surgery, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 99:11399-404. 2002
    ..We compared the effects of inhibitors of VEGF with different specificities in a xenograft model of neuroblastoma. Cultured human neuroblastoma NGP-GFP cells were implanted intrarenally in nude mice...
  91. ncbi Induction of apoptosis by an inhibitor of EGFR in neuroblastoma cells
    Shinichi Tamura
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 358:226-32. 2007
    We aimed to examine the expression of EGFR in neuroblastoma tissues and to investigate the antitumor activity of a selective EGFR-tyrosine kinase inhibitor, gefitinib, on neuroblastoma...
  92. doi PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis
    A Bender
    Department of Hematology Oncology, University Children s Hospital, Ulm, Germany
    Oncogene 30:494-503. 2011
    ..identified activation of phosphatidylinositol 3'-kinase (PI3K)/Akt as a novel predictor of poor outcome in neuroblastoma. Here, we investigated the effect of small-molecule PI3K inhibitors on chemosensitivity...
  93. pmc Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma
    Louis Chesler
    Department of Neurology, Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94143, USA
    Cancer Res 66:8139-46. 2006
    Amplification of MYCN occurs commonly in neuroblastoma. We report that phosphatidylinositol 3-kinase (PI3K) inhibition in murine neuroblastoma (driven by a tyrosine hydroxylase-MYCN transgene) led to decreased tumor mass and decreased ..
  94. ncbi Human NK cell infusions prolong survival of metastatic human neuroblastoma-bearing NOD/scid mice
    Roberta Castriconi
    Department of Experimental Medicine, University of Genoa, Genoa, Italy
    Cancer Immunol Immunother 56:1733-42. 2007
    Several lines of evidence suggest that NK cell immunotherapy may represent a successful approach in neuroblastoma (NB) patients refractory to conventional therapy...
  95. pmc Zebrafish Hagoromo mutants up-regulate fgf8 postembryonically and develop neuroblastoma
    Adam Amsterdam
    David H Koch Institute of Integrative Cancer Research, Cambridge, MA 02139, USA
    Mol Cancer Res 7:841-50. 2009
    ..to adult pigmentation defects, which develop tumors with high penetrance and that histologically resemble neuroblastoma. These tumors are clearly neural in origin, although they do not express catecholaminergic neuronal markers ..
  96. pmc BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists
    K C Goldsmith
    The Children s Hospital of Philadelphia, Philadelphia, 19104 4318, USA
    Cell Death Differ 17:872-82. 2010
    ..Functional mitochondria were isolated from neuroblastoma (NB) cell lines, exposed to distinct BH3-domain peptides, and assayed for cytochrome c release...
  97. doi An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours
    P Mestdagh
    Center for Medical Genetics, Ghent University Hospital, Ghent, East Flanders, Belgium
    Oncogene 29:3583-92. 2010
    ..putative functions of a novel class of non-coding RNAs known as transcribed ultraconserved regions (T-UCRs) in neuroblastoma. Genome-wide expression profiling revealed correlations between specific T-UCR expression levels and important ..
  98. doi Snake venom toxin inhibits cell growth through induction of apoptosis in neuroblastoma cells
    Mi Hee Park
    College of Pharmacy and CBITRC, Chungbuk National University, Cheongju 361 763, Korea
    Arch Pharm Res 32:1545-54. 2009
    ..in many cancer cell lines, but there is no study about the apoptotic effect of snake venom toxin on human neuroblastoma cells...
  99. doi MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response
    Marialaura Petroni
    Department of Experimental Medicine, Sapienza University of Rome, Policlinico Umberto I, Viale Regina Elena, 324, 00161, Rome, Italy
    Mol Cancer Res 9:67-77. 2011
    ..However, MYCN overexpression also sensitizes neuroblastoma cells to apoptosis...
  100. pmc HOXC9 links cell-cycle exit and neuronal differentiation and is a prognostic marker in neuroblastoma
    Ling Mao
    Cancer Center and Department of Pathology, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Cancer Res 71:4314-24. 2011
    Differentiation status in neuroblastoma strongly affects clinical outcomes and inducing differentiation is a treatment strategy in this disease...
  101. ncbi The neurotoxin, MPP+, induces hyperphosphorylation of Tau, in the presence of alpha-Synuclein, in SH-SY5Y neuroblastoma cells
    Tetyana Duka
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington DC 20007, USA
    Neurotox Res 10:1-10. 2006
    ..These data indicate that alpha-Syn and p-Tau modulate the pathogenicity of one another, suggesting a novel convergent mechanism of neurodegeneration...

Research Grants82

  1. Neil W Kowall; Fiscal Year: 2014
    ..We found that LSD1 expression suppresses transcription in transiently transfected SH-SY5Y neuroblastoma cells suggesting that LSD1 expression can regulate transcriptional activity in neurons...
  2. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    b>Neuroblastoma (NB) is the third most common malignancy in childhood and accounts for about 15% of cancer-related deaths in children...
  3. Vickram Ramkumar; Fiscal Year: 2016
    ..ototoxicity is particularly serious in the pediatric population undergoing treatment for cancers such as neuroblastoma. Loss of hearing at this developmental stage hampers speech, cognition and social development...
  4. EFFECT OF DRUGS OF ABUSE ON NEURONAL REDOX AND METHYLATION STATUS
    Richard C Deth; Fiscal Year: 2012
    ..investigation of the influence of selected drugs of abuse on redox and methylation status of cultured human neuroblastoma cells and rat-derived primary cultured neurons...
  5. Thyroid hormone-dependent DNA methylation in the developing brain
    Yasuhiro Kyono; Fiscal Year: 2012
    ..Furthermore, TH induced dnmt3a mRNA in the mouse neuroblastoma cell line N2a[TR21]. Thyroid hormone is essential for neurogenesis during the early postnatal period...
  6. Genetic Susceptibility Factors in the Etiology of Neuroblastoma
    Andrew Olshan; Fiscal Year: 2012
    DESCRIPTION: Neuroblastoma (NB) is a tumor of the peripheral nervous system. It is a neural crest cell derivative, originating from the sympathoadreanal lineage, and its development is related to that of normal sympathetic neurons...
  7. The Role of DNMT3B in the DNA Methylation of Cancer Cells
    LUCY ANN GODLEY; Fiscal Year: 2012
    ..on DNA methylation;(B) correlating DNMT3B7 expression with particular phenotypes in two distinctive types of neuroblastoma cell lines;and (C) quantifying DNMT3B7 levels in primary leukemia samples and correlating those with DNA ..
  8. Oxaloacetate's Brain Effects
    Russell H Swerdlow; Fiscal Year: 2013
    ..In preliminary studies we found adding OAA to neuroblastoma cells robustly increased mitochondrial oxygen consumption...
  9. Yves A DeClerck; Fiscal Year: 2016
    ..on tumor initiation in PAI-1 null mice crossed with transgenic NB-Tag mice that have a 100% penetrance in neuroblastoma tumor formation...
  10. Role of Parkin in Regulating Manganese Toxicity
    JEROME ALLAN ROTH; Fiscal Year: 2010
    ..These studies reveal that neuroblastoma cells overexpressing parkin display both decreased expression of DMT1 as well as increased toxicity towards Mn...
  11. NOVEL THERAPEUTICS FOR PRION DISEASES
    Stanley B Prusiner; Fiscal Year: 2013
    ..Initially, we plan to continue using prion-infected mouse (Mo) neuroblastoma cells designated ScN2a for HTS studies...
  12. Characterization of CHD family chromodomains Implicated in Epigenetic Signaling
    Kimberly R Wiggins; Fiscal Year: 2010
    ..They also have been implicated in diseases such as dermatomyositis, hodgkin's lymphoma, and neuroblastoma (linked with CHD3, CHD4, and CHD5), as well as CHARGE syndrome and idiopathic scoliosis (linked with CHD7)...
  13. Receptor Tyrosine Kinase Sorting and Transactivation in Endosomes
    MARK LINDSAY GRIMES; Fiscal Year: 2010
    ..b>Neuroblastoma cell lines provide a model system to study the molecular mechanisms involved in sorting and transactivation ..
  14. Proteomics Biomarkers Development Laboratory
    Samir Hanash; Fiscal Year: 2009
    ..types investigated to date have included lung, colon and pancreas as well as breast, liver, esophagus and neuroblastoma, resulting in the identification of multiple antigens/autoantibodies that have potential utility as markers ..
  15. Everett Stone; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Neuroblastoma is the most common extra-cranial solid tumor of childhood with an appalling 30% cure rate in children with advanced disease...
  16. Development of sd-rxRNAs as Therapy for Retinoblastoma and Other Malignancies
    Pamela Pavco; Fiscal Year: 2012
    ..an especially attractive target for development because it drives tumorigenesis in diverse cancers, including neuroblastoma, medulloblastoma, and other CNS malignancies...
  17. GUCY2C targeted adoptive T cell therapy to treat metastatic colorectal cancer
    Michael S Magee; Fiscal Year: 2013
    ..an approach to eradicate metastases, producing regression of tumors in patients with melanoma, leukemia, and neuroblastoma. However, this approach has been unsuccessful in colorectal cancer due to toxicities in normal tissues ..
  18. Role of nAChR stoichiometry in nicotine-induced upregulation
    CHRISTOPHER I RICHARDS; Fiscal Year: 2012
    ..of nicotine on this behavior and how it induces differential trafficking to subcellular regions of mouse neuroblastoma cells and cultured neurons will be investigated using total internal reflection microscopy (TIRFM) and ..
  19. Shakeel Modak; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Neuroblastoma (NB) is the most common extracranial solid tumor of childhood...
  20. Impact of Vaccination against GM2, GD2 and GD3 on Disease Free Survival in Resect
    Wolfgang W Scholz; Fiscal Year: 2012
    ..During these 30 years, the antigens expressed by various cancers (neuroblastoma, sarcoma, breast, ovarian, melanoma, etc...
  21. Alice L Yu; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Neuroblastoma is the most common cancer afflicting children under twelve months of age with average age of diagnosis about 18 months...
  22. Lynn Fainsilber Katz; Fiscal Year: 2014
    ..forms of young childhood cancer: acute lymphoblastic leukemia, central nervous system tumors, Wilms tumor and neuroblastoma. The primary aims of the proposed research will be: (1) to describe the course of family conflict across the ..
  23. Vincent R Racaniello; Fiscal Year: 2016
    ..Replication of the IFN-sensitive poliovirus 2Apro mutant Y88L in the human neuroblastoma cell line SK-N-SH is relatively insensitive to IFN, suggesting that these cells may be used as a model for ..
  24. Training program in hematologic and oncologic diseases
    Yi Zheng; Fiscal Year: 2012
    ..diseases, and sickle cell anemia, and targeted therapies against childhood cancers such as leukemia/lymphoma, neuroblastoma, sarcomas, and musculoskeletal tumors...
  25. NF-kappaB N-myc in Oncogenic Pathways of the CNS
    Raquel Sitcheran; Fiscal Year: 2010
    ..Similarly, the N-myc oncogene, which is frequently amplified in aggressive neuroblastoma, can both promote and antagonize cell survival...
  26. Nicotinic acetylcholine receptors and neuroblastoma
    Rae Nishi; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Neuroblastoma is a cancer arising from autonomic neuron progenitor cells that occurs in the adrenal medulla or as paraspinal tumors in the abdomen or thorax of infants and young children...
  27. Martha C Soto; Fiscal Year: 2016
    ..elegans, WAVE3, is down regulated in neuroblastomas and a mutation in WAVE3 has been connected to neuroblastoma and to changes in the actin cytoskeleton...
  28. The Role of Glucocorticoids in Cell Fate Determination
    Brian J Feldman; Fiscal Year: 2010
    ..of cell types including premature lung tissue in the fetus and immature malignancies such as leukemia and neuroblastoma. GCs have also been used as therapy for a wide range of medical conditions including transplant rejection, ..
  29. Douglas R Green; Fiscal Year: 2016
    ..regulated in oncogenesis? Caspase-8, which in humans is present on 2q33, is often silenced or deleted in human neuroblastoma, small cell lung carcinoma, and other cancers...
  30. Min Hee Kang; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Neuroblastoma is a malignant childhood tumor of the sympathetic nervous system...
  31. DANA LYNN TAKEKO KOOMOA; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Neuroblastoma (NB) is an extra-cranial pediatric cancer. Amplification of the proto-oncogene MYCN is associated with advanced stage, high risk NB and poor prognosis...
  32. Paul M Sondel; Fiscal Year: 2014
    ..We found, in a small Phase II immunotherapy trial for neuroblastoma, that patients were more likely to benefit from NK-targeted immunotherapy if they were KIR/KIR-L mismatched...
  33. Cliona M Rooney; Fiscal Year: 2016
    ..Project 3 will take advantage of recent successes with the use of CAR.GD2+ T cells in treatment of advanced neuroblastoma to produce a new generation of modified T cells...
  34. Ototoxicity protection with intratympanic steroid implant
    William H Slattery; Fiscal Year: 2012
    ..Cisplatin is commonly used for the treatment of a variety of cancers, including medulloblastoma, neuroblastoma, osteosarcoma, and testicular, ovarian, cervical, bladder, lung, and head and neck cancers and is considered ..
  35. CB1 Receptor-Mediated Tyrosine Phosphorylation of FAK and ERK in Neurons
    George D Dalton; Fiscal Year: 2012
    ..phosphorylation of focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK) in N18TG2 (N18) neuroblastoma cells...
  36. MYCN Function in Neuroblastoma
    Naohiko Ikegaki; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Neuroblastoma (NB) is a childhood cancer that exhibits either a favorable or an unfavorable phenotype...
  37. Effects of bladder control medication on beta-amyloid peptide metabolism
    Jeremy B Tuttle; Fiscal Year: 2012
    ..on the other hand, reduces AD pathology in the B6C3-Tg (APPswe, PSEN1dE9)85dbo/J AD model mouse and in human neuroblastoma cybrids carrying AD mitochondria...
  38. Chuan He; Fiscal Year: 2014
    ..Despite great progress in the treatment of pediatric cancers, mortality among children with high-risk neuroblastoma remains high, with nearly 60% of the patients developing recurrent disease that is incurable with existing ..
  39. Osteopontin and Collateral Vessel Growth
    WILLIAM ROBERT TAYLOR; Fiscal Year: 2012
    ..Furthermore, recent studies employing transfected murine neuroblastoma cells secreting high levels of osteopontin show that osteopontin enhances local angiogenesis and promotes ..
  40. Protocadherin Gene Expression and Function
    THOMAS P MANIATIS; Fiscal Year: 2012
    ..These studies will be carried out using well-characterized human neuroblastoma cell lines, as well as in the olfactory sensory system of the mouse, which affords the opportunity to study ..
  41. ER-to-cell surface transport and signal regulation of GPCRs
    Guangyu Wu; Fiscal Year: 2013
    ..ER) to the cell surface and GPCR-mediated activation of the mitogen-activated protein kinase pathway in neuroblastoma-glioma NG108 and human embryonic kidney HEK293 cell lines by using alpha2B-adrenergic receptor (alpha2B-AR) as ..
  42. Jianhua Yang; Fiscal Year: 2014
    b>Neuroblastoma (NB) continues to be the most common extracranial solid tumor in children...
  43. Epigenetic Regulation in Cranial Neural Crest Development
    Na Hu; Fiscal Year: 2012
    ..cells are prone to numerous types of cancer, including neurofibromatosis, melanoma, pheochromocytoma and neuroblastoma. Our study of the normal mechanisms of neural crest development will provide important insights in figuring ..
  44. High-throughput screen for specific small-molecule inhibitors of HIF-2A activity
    Mei Yee Koh; Fiscal Year: 2013
    ..HIF-2[unreadable] is an important driver of tumor morbidity in renal cell carcinoma (RCC), neuroblastoma, glioblastoma (GBM) and non small cell lung cancer (NSCLC)...
  45. MOLECULAR GENETIC ANALYSIS OF HUMAN NEUROBLASTOMA
    Garrett M Brodeur; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Neuroblastoma (NB) is a common and deadly tumor of childhood. We identified deletion of 1p as the most characteristic genetic change in NBs. We mapped the region of consistent loss to 2 Mb on 1p36...
  46. Modifiers of Tumor Susceptibility in Murine Neuroblastoma
    William A Weiss; Fiscal Year: 2012
    b>Neuroblastoma, a tumor of peripheral neural crest origin, is a common and lethal tumor of childhood. Amplification of the transcription factor MYCN occurs frequently in this tumor, and correlates with advanced disease...
  47. ELENA LEVITSKAIA; Fiscal Year: 2014
    ..We observed expression of membrane-associated TNF on the surface of neuroblastoma (NB) cells derived from humans or mice...
  48. Reverse ChIP: Sequence-specific extraction of DNA-bound histones for analysis of
    Johannes Dapprich; Fiscal Year: 2012
    ..from specific disease- associated loci from tumor and normal biospecimens, such as the MYCN locus amplified in neuroblastoma. Mass spectrometry is a rapidly growing tool due to its versatility, sensitivity and throughput...
  49. Copy number variations (CNVs) in neuroblastoma
    Sharon Diskin; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Neuroblastoma remains one of the most deadly cancers in children with an overall survival rate for high-risk disease less than 40% despite intensive multi-modal therapy...
  50. LEVON BOSTANIAN; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Neuroblastoma, a neoplasm of the sympathetic nervous system, is the second most common malignant tumor in childhood...
  51. In vivo and crude extract analysis of polyQ aggregation intermediates
    Robert Fairman; Fiscal Year: 2012
    ..A recent study, using crude extracts from a mouse neuroblastoma cell line (2), has identified the presence of oligomers using the newly developed analytical ultracentrifuge ..
  52. Trk Expression and Inhibition in Human Neuroblastomas
    Garrett M Brodeur; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Neuroblastoma (NB) is a common and deadly solid tumor in children that displays heterogeneous clinical behavior, from spontaneous regression to relentless progression...
  53. "Oncorequisite" Genes in MYC-mediated Transformation
    Hui Feng; Fiscal Year: 2010
    ..leukemia (Aims 1 and 2) and then to clarify the importance of the human orthologs of these genes in T-ALL and neuroblastoma pathophysiology, including the consequences of their inhibition (Aim 3)...
  54. Regulation of Stromal Derived Factor-1 Mediated Angiogenesis in Ischemic Brain
    Umadevi V Wesley; Fiscal Year: 2013
    ..levels of SDF1 resulting in increased migratory and angiogenic potential of neural crest stem cell derived neuroblastoma cells. We further observed significantly increased DPPIV expression in the post- ischemic brain...
  55. The iron modulatory function of prion protein and prion disorders
    Neena Singh; Fiscal Year: 2013
    ..will be evaluated in wt, PrPKO, and PrPOV mice, and the underlying mechanism will be investigated in neuroblastoma cells expressing normal and mutant forms of PrP defective in iron transport...
  56. Novel role of STAT3 in NPM/ALK-induced oncogenesis
    Mariusz A Wasik; Fiscal Year: 2013
    ..lymphomas, inflammatory myofibroblastic tumors, subsets of non-small cell lung carcinoma, rhabdomyosacroma, neuroblastoma, glioblastoma and retinoblastoma and, apparently, other malignancies...
  57. Linda H Shapiro; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Neuroblastoma (NB) accounts for 15% of all childhood cancer deaths...
  58. CHRISTOPHER SUMEET BABU GONDI; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Combination therapy to inhibit neuroblastoma growth Neuroblastoma is the most common pediatric solid tumor that arises from the sympathetic nervous system...
  59. Phosphorylation of Prion Protein as a novel mechanism for conversion
    Andrea C LeBlanc; Fiscal Year: 2010
    ..and capable of generating protease-resistant prion protein: normal or mutant prion protein- transfected mouse neuroblastoma N2A cell lines, and human and mouse brains affected by prion diseases...
  60. G Proteins and Opiate Receptor Functions
    Ping Yee Law; Fiscal Year: 2010
    ..Over-expression of these proteins with adenoviruses, or the knockdown of these proteins levels in neuroblastoma N2A cells by siRNA will be carried out to determine their effects on two the effectors regulated by opioid ..
  61. Hypoxia in neuroblastoma
    Guoliang Qing; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Neuroblastoma is a tumor derived from primitive cells of the sympathetic nervous system...
  62. John M Maris; Fiscal Year: 2016
    ..The long-term goal of this research proposal is to discover the heritable component of neuroblastoma, an important childhood cancer that continues to result in significant morbidity and mortality, and to use ..
  63. DOSIMETRY IN CHILDREN AND YOUNG ADULTS WITH NEUROBLASTOMA OR NEUROENDOCRINE TUMOR
    M SUE O DORISIO; Fiscal Year: 2009
    Molecularly targeted radiotherapy using 131I-MIBG has been demonstrated to improve survival in neuroblastoma, but the dose is limited by bone marrow toxicity...
  64. SOMATOSTATIN RECEPTORS--CLASSIFICATION OF NEUROBLASTOMAS
    M O DORISIO; Fiscal Year: 1999
    b>Neuroblastoma is the most common extracranial solid tumor of childhood with an incidence of 9.6/million caucasians and 7.0/million blacks in the US...
  65. Neuroblastoma Tumor Suppressor Genes in Zebrafish
    A Look; Fiscal Year: 2007
    ..leads to disruption of the developing peripheral sympathetic nervous system (PSNS) and ultimately to overt neuroblastoma (NB), a biologically enigmatic, often fatal tumor in young children...
  66. RADIORECEPTOR GUIDED SURGERY OF NEURAL CREST TUMORS
    M O DORISIO; Fiscal Year: 2003
    ..Neural crest tumors derived from these precursors include neuroblastoma in children, neuroendocrine tumors of the gut and melanoma in adults...
  67. RADIORECEPTOR GUIDED SURGERY OF NEURAL CREST TUMORS
    M O DORISIO; Fiscal Year: 2002
    ..Neural crest tumors derived from these precursors include neuroblastoma in children, neuroendocrine tumors of the gut and melanoma in adults...
  68. STRUCTURES OF NEURECTODERM TUMOR GLYCOPROTEINS
    MARY GLICK; Fiscal Year: 1992
    The glycoproteins of human neuroblastoma cells contain a high proportion of fucosyl residues linked alpha 1 leads to 3 to N- acetylglucosamine (Fuc alpha 1 leads to 3G1cNAc) on the oligosaccharide antennae...
  69. DIFFERENTIATION AND APOPTOSIS IN MALIGNANT NEUROBLASTOMA
    Swapan Ray; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Neuroblastoma is the most common malignant disease of early childhood...
  70. Neuroblastoma-Specific MRI Contrast Agents
    Stephan Voss; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Neuroblastoma is the most common pediatric malignancy diagnosed in the first year of life. More than one-half of these children have disseminated disease at the time of diagnosis...
  71. NOVEL COMBINATION THERAPY OF NEUROBLASTOMA
    Nai Kong Cheung; Fiscal Year: 2000
    ..targeted immunotherapy, substantial gains have been made in the curative treatment of patients with stage 4 neuroblastoma diagnosed at over one year of age...
  72. Dosimetry Guided Phase II of 90Y-DOTA-tyr3-Octreotide + Retinoic Acid in Kids
    M SUE SUE O apos DORISIO; Fiscal Year: 2010
    ..rate with 30% partial responses, 24% minimal responses, and 24% stable disease in children with brain tumors, neuroblastoma, and neuroendocrine tumors who had failed previous first and second line therapeutic options...
  73. Beta glucan enhances antibody therapy for neuroblastoma
    Nai Kong Cheung; Fiscal Year: 2003
    ..MoAb) in the therapy of neuroblastoma (NB). Beta-glucans are polysaccharides of low toxicity found in many common foods...
  74. NOVEL TUMOR ANTIGEN FOR ANTIBODY TARGETING
    Nai Kong Cheung; Fiscal Year: 2001
    ..Using the MoAb 3F8 directed at ganglioside GD2, and human neuroblastoma as the tumor model, the investigator has demonstrated over the last 13 years that MoAb can be successfully ..
  75. BIOMARKERS OF TREATMENT RELATED LEUKEMIA
    CAROLYN FELIX; Fiscal Year: 2004
    ..For children with metastatic neuroblastoma receiving N6 therapy, the incidence of leukemia is 7%...
  76. Discovery of Chromosome Arm 11q Tumor Suppressor Genes in Neuroblastoma
    Edward F Attiyeh; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Neuroblastoma remains one of the deadliest cancers in children...
  77. Development of transporter targeted platinum drugs for neuroblastoma
    Richard D Mamelok; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Neuroblastoma (NB) is the most common solid tumor in children...