Genomes and Genes
primitive neuroectodermal tumors
Summary: A group of malignant tumors of the nervous system that feature primitive cells with elements of neuronal and/or glial differentiation. Use of this term is limited by some authors to central nervous system tumors and others include neoplasms of similar origin which arise extracranially (i.e., NEUROECTODERMAL TUMORS, PRIMITIVE, PERIPHERAL). This term is also occasionally used as a synonym for MEDULLOBLASTOMA. In general, these tumors arise in the first decade of life and tend to be highly malignant. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2059)
Publications221 found, 100 shown here
- Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous systemJ Reifenberger
Hautklinik, Heinrich Heine Universitat, Dusseldorf, Germany
Cancer Res 58:1798-803. 1998About one-third of sporadic basal cell carcinomas (BCCs) of the skin and 10-15% of primitive neuroectodermal tumors (PNETs) of the central nervous system show mutations in the PTCH tumor suppressor gene...
- Molecular analysis of childhood primitive neuroectodermal tumors defines markers associated with poor outcomeW G Scheurlen
Children s Hospital, Mannheim, Germany
J Clin Oncol 16:2478-85. 1998The diagnostic and prognostic significance of well-defined molecular markers was investigated in childhood primitive neuroectodermal tumors (PNET).
- Centrosome amplification as a possible mechanism for numerical chromosome aberrations in cerebral primitive neuroectodermal tumors with TP53 mutationsR G Weber
Abteilung Organisation komplexer Genome, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Cytogenet Cell Genet 83:266-9. 1998..1996). Here we report on cerebral primitive neuroectodermal tumors that lacked the wild-type p53 gene (TP53) and showed multiple numerical chromosome aberrations, as ..
- Matrix metalloproteinase expression in childhood medulloblastomas/primitive neuroectodermal tumorsB Bodey
Department of Pathology, University of Southern California, Los Angeles, CA, USA
In Vivo 14:667-73. 2000..Expression of MMP-2, -3, -9, -10, and -13 was investigated in human childhood medulloblastomas (MEDs)/primitive neuroectodermal tumors (PNETs) employing an indirect alkaline phosphatase conjugated immunohistochemical antigen detection ..
- A role for fluorescence in situ hybridization detection of chromosome 22q dosage in distinguishing atypical teratoid/rhabdoid tumors from medulloblastoma/central primitive neuroectodermal tumorsL A Bruch
Department of Pathology (Neuropathology) and Anatomic Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
Hum Pathol 32:156-62. 2001It has been postulated that infants with medulloblastomas/central primitive neuroectodermal tumors (MB/PNET) may fare worse than older patients because some of them harbor unrecognized atypical teratoid/rhabdoid tumors (AT/RT), rare ..
- Germ cell tumor associated primitive neuroectodermal tumorsK N Ganjoo
Division of Hematology-Oncology, Department of Medicine, Indiana University Medical Center, Indianapolis, Indiana, USA
J Urol 165:1514-6. 2001..Patients who present with metastatic primitive neuroectodermal tumor should be treated aggressively with surgical resection as an integral part of the therapeutic strategy...
- Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumorsA Koch
Department of Neuropathology, University of Bonn Medical Center; Bonn, Germany
Int J Cancer 93:445-9. 2001b>Primitive neuroectodermal tumors (PNETs) represent the most frequent malignant brain tumors in childhood. The majority of these neoplasms occur in the cerebellum and are classified as medulloblastomas (MB)...
- Intense p53 staining is a valuable prognostic indicator for poor prognosis in medulloblastoma/central nervous system primitive neuroectodermal tumorsR T Woodburn
Department of Radiation Oncology, Indiana University Medical Center, Indianapolis 46202, USA
J Neurooncol 52:57-62. 2001..Intense p53 immunostaining may predict for a poor prognosis in central nervous system primitive neuroectodermal tumor of childhood...
- Immunohistochemical detection of EWS and FLI-1 proteinss in Ewing sarcoma and primitive neuroectodermal tumors: comparative analysis with CD99 (MIC-2) expressionA Llombart-Bosch
Department of Pathology, Medical School, University of Valencia, Spain
Appl Immunohistochem Mol Morphol 9:255-60. 2001..rearrangement involving EWS/FLI-1 genes is likely to be of diagnostic value in Ewing sarcoma (ES) and primitive neuroectodermal tumors (PNET)...
- Medulloblastomas and primitive neuroectodermal tumors rarely contain polyomavirus DNA sequencesJohn Y H Kim
Division of Neuroscience, Department of Neurology, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Neuro Oncol 4:165-70. 2002..In contrast to childhood ependymomas and choroid plexus tumors, medulloblastomas and sPNETs infrequently express evidence of polyomavirus infection...
- Supratentorial primitive neuroectodermal tumors in adultsDong Gyu Kim
Department of Neurosurgery, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Republic of Korea
J Neurooncol 60:43-52. 2002..Intratumoral calcifications and the Ki-67 labelling index might be prognostic factors, however, it should be considered that the sample size is too small and not all patients were evaluated...
- Insulin-like growth factor I receptor signaling system in JC virus T antigen-induced primitive neuroectodermal tumors--medulloblastomasLuis Del Valle
Center for Neurovirology and Cancer Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Neurovirol 8:138-47. 2002....
- Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of boneHolcombe E Grier
Department of Pediatric Hematology, Dana Farber Cancer Institute and Children s Hospital, Boston, MA 02115, USA
N Engl J Med 348:694-701. 2003..We designed a study to test whether the addition of these drugs to a standard regimen would improve the survival of patients with newly diagnosed disease...
- Farm-related exposures and childhood brain tumours in seven countries: results from the SEARCH International Brain Tumour StudyJimmy T Efird
Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94118, USA
Paediatr Perinat Epidemiol 17:201-11. 2003..0) and unprocessed wool (OR = 3.0). Our findings suggest that various farm-related exposures are positively associated with CBT and warrant further investigation into the public health importance of these associations...
- Morphophenotypic variation predicts clinical behavior in childhood non-desmoplastic medulloblastomasCharles S McManamy
Northern Institute for Cancer Research, University of Newcastle, Newcastle upon Tyne, UK
J Neuropathol Exp Neurol 62:627-32. 2003..Our study supports the concept of an anaplastic variant among MBs, demonstrating that it has clinical utility...
- Evaluation of dietetic intervention in children with medulloblastoma or supratentorial primitive neuroectodermal tumorsJaimie Bakish
Division of Haematology Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
Cancer 98:1014-20. 2003..The goal of the current study was to evaluate the effect of dietetic intervention in a cohort of children treated for medulloblastoma and supratentorial primitive neuroectodermal tumors (PNET) over a 10-year period.
- Primitive neuroectodermal tumors, embryonal tumors, and other small cell and poorly differentiated malignant neoplasms of the central and peripheral nervous systemsHannes Vogel
Department of Pathology Neuropathology, Stanford, CA, USA
Ann Diagn Pathol 7:387-98. 2003..One basic distinction is between primitive neuroectodermal tumors of the central nervous system (cPNETs) and primitive neuroectodermal tumors of the peripheral nervous ..
- High-dose chemotherapy with autologous stem cell rescue as first line of treatment in young children with medulloblastoma and supratentorial primitive neuroectodermal tumorsAntonio Perez-Martinez
Department of Pediatric Hematology and Oncology, Hospital Nino Jesus, Universidad Autonoma de Madrid, Madrid, Spain
J Neurooncol 67:101-6. 2004..the dismal prognosis of patients younger than 4 years old with medulloblastoma and supratentorial primitive neuroectodermal tumors (stPNET) seven young children were treated with high-dose chemotherapy (HDCT) and autologous stem ..
- Somatostatin receptor subtype 2 is expressed by supratentorial primitive neuroectodermal tumors of childhood and can be targeted for somatostatin receptor imagingMichael C Frühwald
Department of Pediatric Hematology and Oncology, University Children s Hospital Muenster, Muenster, Germany
Clin Cancer Res 10:2997-3006. 2004..Novel and refined imaging methodologies are urgently needed...
- Patterns of failure in supratentorial primitive neuroectodermal tumors treated in Children's Cancer Group Study 921, a phase III combined modality studyTheodore S Hong
Department of Human Oncology, University of Wisconsin School of Medicine, Madison, WI, USA
Int J Radiat Oncol Biol Phys 60:204-13. 2004To analyze the patterns of failure in patients with supratentorial primitive neuroectodermal tumors (ST-PNETs) treated with combined modality therapy in a large, randomized, multi-institutional study.
- Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumorsMichael S Bobola
Division of Neurosurgery, Department of Surgery, Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
Clin Cancer Res 11:7405-14. 2005..We assayed apurinic/apyrimidinic endonuclease activity in medulloblastomas and primitive neuroectodermal tumors (PNET) to establish correlates with tumor and patient characteristics and with response to adjuvant ..
- Promoter hypermethylation profile of RASSF1A, FHIT, and sFRP1 in intracranial primitive neuroectodermal tumorsQing Chang
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People s Republic of China
Hum Pathol 36:1265-72. 2005Medulloblastomas (MBs) and supratentorial primitive neuroectodermal tumors (SPNETs) are histologically alike intracranial PNETs found in different anatomical locations of the brain...
- Supratentorial primitive neuroectodermal tumors (S-PNET) in children: A prospective experience with adjuvant intensive chemotherapy and hyperfractionated accelerated radiotherapyMaura Massimino
Neuro Oncology Functional Unit, Department of Pediatric Oncology, Istituto Nazionale Tumori, Milan, Italy
Int J Radiat Oncol Biol Phys 64:1031-7. 2006Supratentorial primitive neuroectodermal tumors (S-PNET) are rare and have a grim prognosis, frequently taking an aggressive course with local relapse and metastatic spread. We report the results of a mono-institutional therapeutic trial.
- Role of radiotherapy in supratentorial primitive neuroectodermal tumor in young children: results of the German HIT-SKK87 and HIT-SKK92 trialsBeate Timmermann
Department of Radiation Oncology and the Institute for Medical Information Processing, University of Tubingen, Tubingen, Germany
J Clin Oncol 24:1554-60. 2006..To assess the outcome of young children with supratentorial primitive neuroectodermal tumor (stPNET) treated by intensive postoperative chemotherapy alone compared with treatment with chemotherapy and delayed radiotherapy (RT)...
- Immunohistochemical analysis of INI1 protein in malignant pediatric CNS tumors: Lack of INI1 in atypical teratoid/rhabdoid tumors and in a fraction of primitive neuroectodermal tumors without rhabdoid phenotypeChristine Haberler
Institute of Neurology, Medical University Vienna, Vienna, Austria
Am J Surg Pathol 30:1462-8. 2006..biopsy specimens of 289 malignant pediatric CNS tumors including medulloblastomas, supratentorial primitive neuroectodermal tumors, glioblastomas, anaplastic astrocytomas, anaplastic ependymomas, choroid plexus carcinomas, germ cell ..
- Supratentorial primitive neuroectodermal tumors of the central nervous system frequently harbor deletions of the CDKN2A locus and other genomic aberrations distinct from medulloblastomasStefan Pfister
Division Molecular Genetics, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Genes Chromosomes Cancer 46:839-51. 2007Supratentorial primitive neuroectodermal tumors (stPNETs) and medulloblastomas have long been thought to arise from a common cell type in the subventricular germinal matrix...
- Supratentorial primitive neuroectodermal tumors: a Canadian pediatric brain tumor consortium reportDonna L Johnston
Division of Hematology Oncology, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON, Canada, K1H 8L1
J Neurooncol 86:101-8. 2008Supratentorial primitive neuroectodermal tumors (SPNET) are rare tumors accounting for only 2.5% of childhood brain tumors...
- Intensive chemotherapy followed by consolidative myeloablative chemotherapy with autologous hematopoietic cell rescue (AuHCR) in young children with newly diagnosed supratentorial primitive neuroectodermal tumors (sPNETs): report of the Head Start I and IJason Fangusaro
Children s Hospital Los Angeles, Los Angeles, California, USA
Pediatr Blood Cancer 50:312-8. 2008Children with newly diagnosed supratentorial primitive neuroectodermal tumors (sPNET) have poor outcomes compared to medulloblastoma patients, despite similar treatments...
- Surgical treatment and prognosis of primitive neuroectodermal tumors of the thoraxAdalet Demir
Department of Thoracic Surgery, Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery, Istanbul University, Istanbul, Turkey
J Thorac Oncol 4:185-92. 2009b>Primitive neuroectodermal tumors (PNETs) are rare, rapidly progressive, small- round cell tumors with a poor prognosis despite multimodal therapy, including surgery and chemoradiotherapy...
- Boost radiosurgery as a strategy after failure of initial management of pediatric primitive neuroectodermal tumorsThomas Flannery
Department of Neurological Surgery and Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15123, USA
J Neurosurg Pediatr 3:205-10. 2009..this study was to determine the outcomes of boost stereotactic radiosurgery, specifically Gamma Knife surgery (GKS), for recurrent primitive neuroectodermal tumors (PNETs) in children in whom initial multimodality management had failed.
- High-dose chemotherapy and autologous hematopoietic progenitor cell rescue in children with recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors: the impact of prior radiotherapy on outcomeAnna M Butturini
Division of Hematology Oncology, Childrens Hospital Los Angeles and Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Cancer 115:2956-63. 2009The role of myeloablative chemotherapy in children with recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors (MB/ST-PNET) is controversial, in particular in patients who develop recurrent disease after ..
- INSM1 promoter-driven adenoviral herpes simplex virus thymidine kinase cancer gene therapy for the treatment of primitive neuroectodermal tumorsHong Wei Wang
Research Institute for Children, Children s Hospital, New Orleans, LA 70118, USA
Hum Gene Ther 20:1308-18. 2009..of an adenoviral INSM1 promoter-driven herpes simplex virus thymidine kinase (HSV-tk) construct in primitive neuroectodermal tumors (PNETs). We constructed an adenoviral INSM1 promoter-driven HSV-tk gene for therapy in PNETs...
- Central nervous system primitive neuroectodermal tumors: a clinicopathologic and genetic study of 33 casesAmir Behdad
Department of Pathology, Cedar Sinai Medical Center, Los Angeles, Calif, USA
Brain Pathol 20:441-50. 2010Central nervous system (CNS) primitive neuroectodermal tumors (PNETs) include supratentorial, brain stem, and spinal cord tumors with medulloblastoma-like histopathology...
- Amplification and overexpression of KIT, PDGFRA, and VEGFR2 in medulloblastomas and primitive neuroectodermal tumorsTea Blom
Molecular Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P O Box 63, 00014, University of Helsinki, Finland
J Neurooncol 97:217-24. 2010Medulloblastomas (MB) and primitive neuroectodermal tumors (PNET) are the most common malignant brain tumors in children. These two tumor types are histologically similar, but have different genetic backgrounds and clinical outcomes...
- Intraspinal primitive neuroectodermal tumors: Report of four cases and review of the literatureChen Jingyu
Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing 400 038, The People s Republic of China
Neurol India 57:661-8. 2009Intraspinal primitive neuroectodermal tumors (PNETs) are extremely rare and are aggressive with poor outcomes. Till date only 41 cases of intraspinal PNET have been reported. Here we report four new cases...
- Imaging findings of primitive neuroectodermal tumors of the kidneyHyun Lee
Department of Radiology, Hallym University Sacred Heart Hospital, Seoul, Republic of Korea
J Comput Assist Tomogr 33:882-6. 2009..This study was designed to present the radiological imaging findings of a renal primitive neuroectodermal tumor (PNET)...
- Non-cerebellar primitive neuroectodermal tumors (PNET): summary of the Milan consensus and state of the art workshop on marrow ablative chemotherapy with hematopoietic cell rescue for malignant brain tumors of childhood and adolescentsJason Fangusaro
Pediatric Hematology Oncology and Stem Cell Transplantation, Children s Memorial Hospital Chicago, Chicago, Illinois 60614, USA
Pediatr Blood Cancer 54:638-40. 2010CNS non-cerebellar primitive neuroectodermal tumors (PNET) represent <5% of all childhood brain tumors. Despite similar therapies, these patients have had significantly worse outcomes compared to patients with medulloblastoma...
- Treatment of high-risk medulloblastoma and other primitive neuroectodermal tumors with reduced dose craniospinal radiation therapy and multi-agent nitrosourea-based chemotherapyM D Prados
Department of Neurosurgery, University of California, San Francisco, USA
Pediatr Neurosurg 25:174-81. 1996..survival (PFS) of children and adults with newly diagnosed medulloblastoma, pineoblastoma, and other primitive neuroectodermal tumors (PNET) with a combined modality regimen of radiation therapy and adjuvant nitrosourea-based ..
- Mutations of the INI1 rhabdoid tumor suppressor gene in medulloblastomas and primitive neuroectodermal tumors of the central nervous systemJ A Biegel
Division of Human Genetics and Molecular Biology, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
Clin Cancer Res 6:2759-63. 2000..Detection of these mutations suggests that the child has an AT/RT, rather than a MB/PNET, a finding with important prognostic value...
- Abundance of apoptotic neoplastic cells in diagnostic biopsy samples is not a prognostic factor in childhood primitive neuroectodermal tumors of the central nervous systemM A Grotzer
Division of Oncology, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA
J Pediatr Hematol Oncol 23:25-9. 2001PURPOSE: To assess if the abundance of apoptotic tumor cells is an independent prognostic factor in primitive neuroectodermal tumors (PNET) of the central nervous system...
- Prognostic significance of Ki-67 (MIB-1) proliferation index in childhood primitive neuroectodermal tumors of the central nervous systemM A Grotzer
Division of Neurology and Oncology, The Children's Hospital of Philadelphia, Pennsylvania 19104, USA
Med Pediatr Oncol 36:268-73. 2001BACKGROUND: Primitive neuroectodermal tumors (PNET) of the central nervous system, including medulloblastomas, are the most common malignant brain tumors of childhood...
- Parental occupations and childhood brain tumors: results of an international case-control studyS Cordier
INSERM, Villejuif, France
Cancer Causes Control 12:865-74. 2001..sex, year of birth, and center, for all types of CBT combined and for the subgroups of astroglial, primitive neuroectodermal tumors (PNET), and other glial tumors...
- Overexpression of cyclooxygenase-2 (COX-2) in human primitive neuroectodermal tumors: effect of celecoxib and rofecoxibRatnakar Patti
Division of Neuro Oncology, Joseph Stokes Research Institute 515G, 3516 Civic Center Blvd, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Cancer Lett 180:13-21. 2002..Growth inhibition by celecoxib and rofecoxib was independent of Bcl-2 expression. Celecoxib suppressed the expression of Akt and activated the caspase-3 in DAOY and PFSK, whereas rofecoxib did not have such an effect...
- Molecular genetic analysis of the TP53, PTEN, CDKN2A, EGFR, CDK4 and MDM2 tumour-associated genes in supratentorial primitive neuroectodermal tumours and glioblastomas of childhoodJ A Kraus
Department of Neurology, University of Bonn, Medical Center, Bonn, Germany
Neuropathol Appl Neurobiol 28:325-33. 2002..In addition, the patterns of genetic alterations in sPNETs and paediatric GBMs appear to be distinct from those in cerebellar medulloblastomas and adult GBMs, respectively...
- Primitive neuroectodermal tumors in the central nervous system following cranial irradiation: a report of four casesWalter J Hader
Division of Neurosurgery, Department of Clinical Neurosciences, University of Calgary, Calgary, Canada
Cancer 97:1072-6. 2003..The development of primitive neuroectodermal tumors (PNETs) following prophylactic craniospinal irradiation has been infrequently reported previously...
- Dynamic susceptibility contrast-enhanced perfusion and conventional MR imaging findings for adult patients with cerebral primitive neuroectodermal tumorsMeng Law
Department of Radiology, New York University Medical Center, New York, NY 10016, USA
AJNR Am J Neuroradiol 25:997-1005. 2004Preoperative differentiation of primitive neuroectodermal tumors (PNETs) from other tumors is important for presurgical staging, intraoperative management, and postoperative treatment...
- High-dose chemotherapy with autologous stem cell rescue for children with high risk and recurrent medulloblastoma and supratentorial primitive neuroectodermal tumorsAntonio Perez-Martinez
Department of Pediatric Hematology and Oncology, Hospital Nino Jesus, Universidad Autonoma de Madrid, Spain
J Neurooncol 71:33-8. 2005Current treatment for high risk and recurrent medulloblastoma (MB) and supratentorial primitive neuroectodermal tumors (stPNET) has a very poor prognosis in children...
- Treatment strategies for high-risk medulloblastoma and supratentorial primitive neuroectodermal tumors. Review of the literatureRegina I Jakacki
Division of Pediatric Hematology Oncology, Children s Hospital of Pittsburgh, Pennsylvania 15213, USA
J Neurosurg 102:44-52. 2005b>Primitive neuroectodermal tumors (PNETs) are malignant tumors with a high propensity to disseminate throughout the cerebrospinal fluid...
- Analysis of patients with supratentorial primitive neuro-ectodermal tumours entered into the SIOP/UKCCSG PNET 3 studyBarry L Pizer
Alder Hey s Children s Hospital Oncology Unit, Eaton Road, Liverpool L12 2AP, UK
Eur J Cancer 42:1120-8. 2006..Future treatment programs should be directed at the particular natural history of these tumours, to further define prognostic factors and to explore further biological characteristics...
- High-resolution array-based comparative genomic hybridization of medulloblastomas and supratentorial primitive neuroectodermal tumorsMartin Gerard McCabe
Department of Pathology, University of Cambridge, Division of Molecular Histopathology, UK
J Neuropathol Exp Neurol 65:549-61. 2006Medulloblastomas and supratentorial primitive neuroectodermal tumors are aggressive childhood tumors...
- RASSF1A promoter is highly methylated in primitive neuroectodermal tumors of the central nervous systemMaria del Mar Inda
Unidad de Biología de Tumores Cerebrales, Universidad de Navarra, Pamploma, Spain
Neuropathology 27:341-6. 2007..b>Primitive neuroectodermal tumors (PNET) of the central nervous system can be divided into infratentorial PNET or medulloblastoma (MB), ..
- Radiation is an important component of multimodality therapy for pediatric non-pineal supratentorial primitive neuroectodermal tumorsSean M McBride
Department of Radiation Oncology, University of California San Francisco, San Francisco, CA
Int J Radiat Oncol Biol Phys 72:1319-23. 2008To review a historical cohort of pediatric patients with supratentorial primitive neuroectodermal tumors (sPNET), to clarify the role of radiation in the treatment of these tumors.
- Role of high-dose chemotherapy for recurrent medulloblastoma and other CNS primitive neuroectodermal tumorsAmar Gajjar
St Jude Children s Research Hospital, Memphis, Tennessee, USA
Pediatr Blood Cancer 54:649-51. 2010..chemotherapy (HDCT) with stem cell rescue for patients with recurrent medulloblastoma and other primitive neuroectodermal tumors as presented at an international consensus and state of the art workshop held in Milan in 2006...
- Computed tomography imaging of anterior and middle mediastinal Ewing sarcoma/primitive neuroectodermal tumorsWei Dong Zhang
State Key Laboratory of Oncology, South China, Guangdong 510060, PR China
J Thorac Imaging 25:168-72. 2010We describe the computed tomography (CT) imaging features of Ewing sarcoma (EWS)/primitive neuroectodermal tumors (PNETs) arising in the anterior and middle mediastinum.
- The molecular pathology of p53 in primitive neuroectodermal tumours of the central nervous systemA S Y W Burns
Cancer Research Unit, Medical School University of Newcastle, Newcastle upon Tyne, UK
Br J Cancer 86:1117-23. 2002..Multivariate analyses supported the prognostic value of p53 immunostaining in central primitive neuroectodermal tumours and also of age and gender of patients...
- Malignant teratoma of the thyroid with primitive neuroepithelial and mesenchymal sarcomatous componentsR D Craver
Department of Pathology, Children's Hospital, Louisiana State University Medical Center, 200 Henry Clay Ave, New Orleans, LA 70118, USA
Ann Diagn Pathol 5:285-92. 2001..Trisomy 8 is the first cytogenetic abnormality described in malignant thyroid teratoma. Therapy should be tailored to the management of all transformed histologies...
- A novel case of a CAT to AAT transversion in codon 179 of the p53 gene in a supratentorial primitive neuroectodermal tumor harbored by a young girl. Case report and review of the literatureSergey Postovsky
Department of Pedicatric Hematology Onclology, Rambam Medical Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
Oncology 65:46-51. 2003The most common cytogenetic abnormality encountered in primitive neuroectodermal tumors (PNET)/medulloblastoma is loss of heterozygosity in the region of the short arm of chromosome 17...
- Central nervous system medulloepithelioma: a series of eight cases including two arising in the ponsP T Molloy
Department of Pathology, The Children s Hospital of Philadelphia, Department of Pathology, The Children s Hospital of Philadelphia Pennsylvania, USA
J Neurosurg 84:430-6. 1996..CNS) whose histopathological appearance has been confused with medulloblastoma and other childhood primitive neuroectodermal tumors (PNETs), but which has a vastly different clinical course...
- Feasibility of four consecutive high-dose chemotherapy cycles with stem-cell rescue for patients with newly diagnosed medulloblastoma or supratentorial primitive neuroectodermal tumor after craniospinal radiotherapy: results of a collaborative studyD Strother
Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
J Clin Oncol 19:2696-704. 2001..The early outcome results of this approach are very encouraging...
- Antineuronal nuclei immunohistochemical staining patterns in childhood ependymomasJ R Parker
Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
J Child Neurol 16:548-52. 2001..Five astrocytomas, four primitive neuroectodermal tumors, and normal cerebral cortex and ependyma from autopsy brains of premature newborns, term infants, and ..
- Absence of germline and somatic p53 alterations in children with sporadic brain tumorsC Portwine
Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada
J Neurooncol 52:227-35. 2001..However, the potential significance of LOH at codon 72 remains to be elucidated...
- Ex vivo pediatric brain tumors express Fas (CD95) and FasL (CD95L) and are resistant to apoptosis inductionC D Riffkin
Department of Hematology and Oncology, Royal Children's Hospital, Melbourne, Victoria, Australia
Neuro Oncol 3:229-40. 2001..The results suggest that Fas expression may be a general feature of tumors of the CNS and that a significant degree of resistance to Fas-mediated apoptosis may exist in ex vivo pediatric brain tumor specimens...
- Angiogenic profile of childhood primitive neuroectodermal brain tumours/medulloblastomasH Huber
Division of Oncology, The Children's Hospital of Philadelphia, PA 19104, USA
Eur J Cancer 37:2064-72. 2001..This suggests that anti-angiogenesis approaches targeting VEGF alone may be insufficient in PNET/MB...
- Loss of caspase-8 mRNA expression is common in childhood primitive neuroectodermal brain tumour/medulloblastomaT J Zuzak
Division of Oncology, University Children s Hospital of Zurich, Switzerland
Eur J Cancer 38:83-91. 2002..We conclude that loss of caspase-8 gene expression is common in PNET/medulloblastoma suggesting that suppression of death receptor induced apoptosis may play an important role in the pathogenesis of this common childhood brain tumour...
- Diffusion-weighted imaging and fluid attenuated inversion recovery imaging in the evaluation of primitive neuroectodermal tumorsE Erdem
Department of Radiology, The Children's Hospital of Philadelphia, PA 19104, USA
Neuroradiology 43:927-33. 2001..recovery (FLAIR) imaging and diffusion-weighted imaging (DWI) would be helpful in characterizing primitive neuroectodermal tumors (PNET) from other pediatric brain tumors...
- Supratentorial embryonal tumors in children under 5 years of age: an SFOP study of treatment with postoperative chemotherapy aloneP Marec-Berard
Pediatric Unit, Centre Leon Berard, 69373 Lyon, France
Med Pediatr Oncol 38:83-90. 2002..To determine the effectiveness of multiagent chemotherapy as sole post-operative treatment of supratentorial central nervous system (CNS) embryonal tumors in young children...
- Risk assignment in childhood brain tumors: the emerging role of molecular and biologic classificationIan F Pollack
Department of Neurosurgery, Children s Hospital of Pittsburgh, Main Tower, Floor 3, Room 3705, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
Curr Oncol Rep 4:114-22. 2002..This paper summarizes these observations and discusses how they are being applied in a preliminary fashion as a foundation for risk-adapted stratification of childhood brain tumor therapy...
- Chlorotoxin, a scorpion-derived peptide, specifically binds to gliomas and tumors of neuroectodermal originSusan A Lyons
TransMolecular, Inc, Birmingham, Alabama 35294, USA
Glia 39:162-73. 2002..These results suggest that chlorotoxin is a reliable and specific histopathological marker for tumors of neuroectodermal origin and that chlorotoxin derivatives with cytolytic activity may have therapeutic potential for these cancers...
- Basal ganglia and thalamic tumours: an imaging approximationJosé M García-Santos
Neuroradiology Section, Hospital General Universitario, J Ma Morales Meseguer, C Marques de los Vélez s n, 30008 Murcia, Spain
Childs Nerv Syst 18:412-25. 2002..In other occasions peripheral neoplasms developing in neighbouring structures like the cerebral lobes, the ventricular walls, choroidal plexus, pineal gland and the hypothalamic-chiasmatic-suprasellar region can spread to the deep brain...
- Relation between Irofulven (MGI-114) systemic exposure and tumor response in human solid tumor xenograftsMarkos Leggas
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Clin Cancer Res 8:3000-7. 2002....
- Primary intracranial atypical teratoid/rhabdoid tumor in a child: a case reportYou Nam Chung
Department of Neurosurgery, Seoul National University College of Medicine and Neurological Research Institute, SNUMRC, Seoul, Korea
J Korean Med Sci 17:723-6. 2002..Despite aggressive therapy, he died 19 months after diagnosis. Clinical, radiological, and histopathological features of primary intracranial ATT/RhT are discussed with a special emphasis on the differential diagnosis from PNET-MB...
- hTERT gene amplification and increased mRNA expression in central nervous system embryonal tumorsXing Fan
Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Am J Pathol 162:1763-9. 2003..Our data indicate that hTERT gene amplification is relatively common in embryonal brain tumors, and that increased expression of hTERT mRNA may be associated with biologically aggressive tumor behavior...
- Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomasKar Ming Fung
Department of Pathology, University of Oklahoma Health Science Center OUHSC, Rm 451, 940 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
Acta Neuropathol 106:167-75. 2003..Of medulloblastomas, 76% have immunoreactivity for either alpha- or beta-synuclein or both; no immunoreactivity for gamma-synuclein is seen in medulloblastomas...
- Mediastinal T-cell lymphoma in a boy 7 years after treatment of supratentorial primitive neuroectodermal tumorThomas Lehrnbecher
Department of Pediatric Hematology and Oncology, Children s Hospital III, Frankfurt, Germany
J Pediatr Hematol Oncol 25:657-9. 2003..In addition, patients with second malignancies should be considered as a high-risk population for opportunistic infections...
- Primitive neuroectodermal tumor of the head and neck: incidence, diagnosis, and managementJochen P Windfuhr
Department of Otorhinolaryngology Plastic Head and Neck Surgery, St Anna Hospital, Duisburg, Germany
Ann Otol Rhinol Laryngol 113:533-43. 2004b>Primitive neuroectodermal tumors are in the Ewing's sarcoma family of tumors and are composed of small round cells. Because of their rare occurrence, optimal therapy is challenging, particularly if they occur in the head and neck...
- Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supratentorial primitive neuroectodermal tumorClinton F Stewart
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
J Clin Oncol 22:3357-65. 2004..efficacy of pharmacokinetically guided topotecan dosing in previously untreated patients with medulloblastoma and supratentorial primitive neuroectodermal tumors, and to evaluate plasma and CSF disposition of topotecan in these patients.
- [Refractory partial epilepsy: morphological imaging in children]C Raybaud
Neuroradiologie, CHU Timone, Universite de la Mediterranee, 13000 Marseille, France
Rev Neurol (Paris) 160:5S106-16. 2004..In the event of a simple lesion, the decision for surgery on the basis of morphological data alone is more easily made in children than in adults...
- Notch1 and notch2 have opposite effects on embryonal brain tumor growthXing Fan
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cancer Res 64:7787-93. 2004..Our data indicate that Notch1 and Notch2 can have opposite effects on the growth of a single tumor type, and show that Notch2 can be overexpressed after gene amplification in human tumors...
- Atypical teratoid/rhabdoid tumor of the brain: cytopathologic characteristics and differential diagnosisAnil V Parwani
Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
Cancer 105:65-70. 2005..Although the clinicopathologic and radiologic features of AT/RT have been described previously, to the authors' knowledge the cytomorphologic profile of this tumor has not been studied well...
- Epigenetic inactivation of DLC-1 in supratentorial primitive neuroectodermal tumorJesse Chung Sean Pang
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, People s Republic of China
Hum Pathol 36:36-43. 2005Supratentorial primitive neuroectodermal tumors (SPNETs) and medulloblastomas (MBs) are histologically similar intracranial tumors found in different anatomic locations of the brain...
- Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virusCharles G Eberhart
Department of Pathology, Johns Hopkins University School of Medicine, Ross Bldg 558, 720 Rutland Ave, Baltimore, MD 21205, USA
BMC Cancer 5:19. 2005..We correlated p53 protein expression with pathological subtype and clinical outcome in 75 embryonal brain tumors. The presence of JC virus, which results in p53 protein accumulation, was also examined...
- Patterns of treatment failure in infants with primitive neuroectodermal tumors who were treated on CCG-921: a phase III combined modality studyTheodore S Hong
Department of Human Oncology, School of Medicine, University of Wisconsin, Madison, WI 53792, USA
Pediatr Blood Cancer 45:676-82. 2005To analyze patterns of treatment failure in infants with primitive neuroectodermal tumors (PNETs) who were treated primarily with chemotherapy in a large multi-institutional study.
- The therapy of infantile malignant brain tumors: current status?Chantal Kalifa
Pediatric Department, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805, Villejuif Cedex, France
J Neurooncol 75:279-85. 2005..With these informations it is now possible to design therapeutic trials devoted to each histological types, adapted to pronostic factors and more accurate treatment to decrease long term sequelae...
- Genetic heterogeneity in supratentorial and infratentorial primitive neuroectodermal tumours of the central nervous systemM M Inda
Laboratoire de Génomique Cellulaire des Cancers, UMR1599, CNRS, Institut Gustave Roussy, Villejuif, France
Histopathology 47:631-7. 2005..We investigated the differences in genetic abnormalities between sPNET and MB...
- Outcome for children <4 years of age with malignant central nervous system tumors treated with high-dose chemotherapy and autologous stem cell rescueHalldora K Thorarinsdottir
Division of Hematology and Oncology, Children s National Medical Center, Washington, District of Columbia, USA
Pediatr Blood Cancer 48:278-84. 2007....
- Boron neutron capture therapy using mixed epithermal and thermal neutron beams in patients with malignant glioma-correlation between radiation dose and radiation injury and clinical outcomeTeruyoshi Kageji
Department of Neurosurgery, Graduate School of Health Biosciences, The University of Tokushima, Tokushima, Japan
Int J Radiat Oncol Biol Phys 65:1446-55. 2006..To clarify the correlation between the radiation dose and clinical outcome of sodium borocaptate-based intraoperative boron neutron capture therapy in patients with malignant glioma...
- Role of spinal MRI in the follow-up of children treated for medulloblastomaUte Bartels
Division of Haematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
Cancer 107:1340-7. 2006..The purpose of the current study was to describe the usefulness of spinal magnetic resonance imaging (MRI) in children with medulloblastoma or primitive neuroectodermal tumor (PNET) of the posterior fossa...
- Phase II study of oxaliplatin in children with recurrent or refractory medulloblastoma, supratentorial primitive neuroectodermal tumors, and atypical teratoid rhabdoid tumors: a pediatric brain tumor consortium studyMaryam Fouladi
St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
Cancer 107:2291-7. 2006..II study of oxaliplatin was conducted to evaluate its safety and efficacy in children with recurrent or refractory medulloblastoma (MB), supratentorial primitive neuroectodermal tumors (SPNET), and atypical teratoid rhabdoid tumor (ATRT).
- High-dose chemotherapy and autologous stem cell rescue in children with newly diagnosed high-risk or relapsed medulloblastoma or supratentorial primitive neuroectodermal tumorKi Woong Sung
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Pediatr Blood Cancer 48:408-15. 2007....
- Paediatric PNET: pre-surgical MRI featuresA Chawla
Department of Neuroradiology, National Neuroscience Institute, Singapore
Clin Radiol 62:43-52. 2007....
- Incidence and severity of postoperative cerebellar mutism syndrome in children with medulloblastoma: a prospective study by the Children's Oncology GroupPatricia L Robertson
Department of Pediatrics, University of Michigan Health System, Ann Arbor, Michigan 48109 0203, USA
J Neurosurg 105:444-51. 2006..Most descriptions have been limited to small institutional series using a retrospective chart review methodology...
- Frequent but borderline methylation of p16 (INK4a) and TIMP3 in medulloblastoma and sPNET revealed by quantitative analysesJ Mühlisch
Department of Pediatric Hematology and Oncology, University Children s Hospital Muenster, 48129 Muenster, Germany
J Neurooncol 83:17-29. 2007..Therapeutic and diagnostic implications urge into depth analyses of methylation as a mechanism, which might fill some of the gaps of our understanding of brain tumor origin...
- The Azzopardi phenomenonHidehiro Takei
Arch Pathol Lab Med 131:518. 2007
- Tumor suppressor proteins are differentially affected in human ependymoblastoma and medulloblastoma cells exposed to nerve growth factorA Antonelli
Institute of Neurobiology and Molecular Medicine, CNR EBRI, Rome, Italy
Cancer Invest 25:94-101. 2007..These observations indicate that NGF by interfering with mechanisms associated with cells proliferation and survival might induce the differentiation event through TrkA pathways...
- Thyroid-stimulating hormone suppression for protection against hypothyroidism due to craniospinal irradiation for childhood medulloblastoma/primitive neuroectodermal tumorMaura Massimino
Department of Pediatrics, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
Int J Radiat Oncol Biol Phys 69:404-10. 2007..Hence, our study was launched in 1998 to evaluate the protective effect of TSH suppression during CSI for medulloblastoma/primitive neuroectodermal tumor...
- Type I collagen is overexpressed in medulloblastoma as a component of tumor microenvironmentYu Liang
Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, San Francisco, CA 94143, USA
J Neurooncol 86:133-41. 2008....
- [Experience with the intrathecal use of liposomal cytarabine at the Besta Institute]Antonio Silvani
Istituto Nazionale Neurologico Carlo Besta, Milano
Tumori 93:suppl 6-8. 2007
- Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology GroupH Stacy Nicholson
Department of Pediatrics, Oregon Health Science and University, Portland, Oregon, USA
Cancer 110:1542-50. 2007..Effective chemotherapy is lacking for most types of central nervous system (CNS) tumors in children. Temozolomide, an agent with activity against adult brain tumors, was investigated in children and adolescents with recurrent CNS tumors...
- Brain magnetic resonance imaging after high-dose chemotherapy and radiotherapy for childhood brain tumorsFilippo Spreafico
Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
Int J Radiat Oncol Biol Phys 70:1011-9. 2008..Brain necrosis or other subacute iatrogenic reactions has been recognized as a potential complication of radiotherapy (RT), although the possible synergistic effects of high-dose chemotherapy and RT might have been underestimated...
- Feasibility of metronomic maintenance chemotherapy following high-dose chemotherapy for malignant central nervous system tumorsL Mi Rim Choi
Division of Hematology and Oncology, Children s National Medical Center, Washington, District of Columbia, USA
Pediatr Blood Cancer 50:970-5. 2008..Metronomic chemotherapy has also been reported as a potential new treatment strategy in solid tumors, particularly in adults...
- Hypofractionated stereotactic radiotherapy in the management of recurrent or residual medulloblastoma/PNETFrank Saran
Neuro oncology Unit and the Academic Unit of Radiotherapy and Oncology, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom
Pediatr Blood Cancer 50:554-60. 2008To evaluate the efficacy and toxicity of hypofractionated stereotactic radiotherapy in the management of locally recurrent or residual central nervous system (CNS) primitive neuroectodermal tumors (PNETs).
- Inhibition of matrix proteases to sensitize medulloblastoma cells to radiationAndrei L Gartel; Fiscal Year: 2013Medulloblastomas, which belong to a group of primitive neuroectodermal tumors, are invasive tumors with predominant neuronal differentiation...
- Pesticide Exposure and Childhood Cancer StudyBeate R Ritz; Fiscal Year: 2012..cancers (acute myeloid leukemia, acute lymphoblastic leukemia, non Hodgkin lymphoma, astrocytoma, primitive neuroectodermal tumors, Wilms tumor, soft tissue sarcomas) and population-based controls...
- Cellular plasticity and survival mechanisms in medulloblastoma stem cellsRonnie Yoo; Fiscal Year: 2013..abstract_text> ..
- 'Exvading'Invasive Pediatric Brain TumorsRavi V Bellamkonda; Fiscal Year: 2013DESCRIPTION (provided by applicant): Medulloblastomas are highly invasive primitive neuroectodermal tumors of the cerebellum and the most common childhood malignant brain tumor, constituting 20-40% of pediatric brain tumors...
- Clinical pharmacology of cyclophosphamide in pediatric medulloblastoma patientsMichael B Tagen; Fiscal Year: 2010DESCRIPTION (provided by applicant): Medulloblastoma and primitive neuroectodermal tumors (PNETs) are childhood brain tumors where about 40% of patients die due to early tumor recurrence...
- Edward A Neuwelt; Fiscal Year: 2014..potential for enhancing chemotherapy dose intensity for intracerebral medulloblastoma as a model of primitive neuroectodermal tumors within brain parenchyma, by using BBBD and by depleting glutathione stores in conjunctions with thiol ..
- Human Neurotropic JC Virus and CNS DiseasesKamel Khalili; Fiscal Year: 2006..By using the early genome of JCV, we have created transgenic animals that develop cerebellar primitive neuroectodermal tumors with extraordinary similarity to human medulloblastoma...
- Academic Public Private Partnership ProgramM O DORISIO; Fiscal Year: 2004..neuroendocrine tumors seen in adults, pediatric neuroendocrine tumors thus include neuroblastoma and primitive neuroectodermal tumors (PNET) such as medulloblastoma, supratentorial PNET and the Ewings sarcoma family of tumors...
- MOLECULAR ANALYSIS OF PEDIATRIC CANCERSGiovanni Rovera; Fiscal Year: 1993..Project 3 will identify and characterize NGF induced immediate-early genes in primitive neuroectodermal tumors which are incompetent to trans activity other genes whose expression is required for terminal ..
- PRIMITIVE NEUROECTODERMAL TUMORS OF CHILDHOODPeter Phillips; Fiscal Year: 2000Medulloblastoma (MB) and related CNS primitive neuroectodermal tumors (PNETs) are the most common pediatric malignant brain tumors and major source of neurological morbidity and mortality in children...
- CELL DEATH AND DIFFERENTIATION IN MEDULLOBLASTOMAJohn Trojanowski; Fiscal Year: 1999Medulloblastomas (MBs) are prototypical primitive neuroectodermal tumors (PNETs) of the cerebellum, and they are among the most common pediatric brain tumors...
- SONIC HEDGEHOG/PTCH PATHWAY IN PNETCorey Raffel; Fiscal Year: 2000..b>Primitive neuroectodermal tumors are the most common of these...
- Parallel Peptide Tandem Mass Spectrometry (MS)David Goodlett; Fiscal Year: 2003..This work will be done with medulloblastoma cell lines and primary cells lines derived from retinoid-sensitive and -resistant tumors. ..
- Mediators of EWS/FLI Oncogenesis in Ewing's SarcomaWilliam May; Fiscal Year: 2005..This understanding will provide a valuable paradigm for the study of the wide array of malignancies that are associated with aberrant transcription factors. ..
- Mammalian genetic analysis of embryonic neural overgrow*Karen Artzt; Fiscal Year: 2006..It is expected that this set of genes will define a new tumor suppressor that plays-a role in the development of primitive neuroectodermal tumors of children.
- Lapatinib in childhood CNS malignanciesMaryam Fouladi; Fiscal Year: 2006..These data will be used in the rational design of future phase I combination or frontline studies to improve the outcome in children with these poor prognosis tumors. [unreadable] [unreadable]..
- Myc Signaling in MedulloblastomasCharles Eberhart; Fiscal Year: 2006..Finally, in Specific Aim 4 we propose developing a novel medulloblastoma transgenic model by overexpressing c-Myc in the cerebellum of transgenic mice. ..
- Regulation- Medulloblastoma Growth by alpha-v integrinsTobey Macdonald; Fiscal Year: 2006..The long-range goal of this work is to broaden our understanding of medulloblastoma growth, so that novel biologic therapies may be developed into new treatments for medulloblastoma, the most common malignant brain tumor in children. ..
- CONTROL SELECTION METHODS FOR CHILDHOOD CANCER STUDIESGreta Bunin; Fiscal Year: 2009..A feasible and valid control group is needed to ensure that studies of childhood cancer are scientifically valid and therefore, will provide results that can eventually lead to prevention of these cancers. ..
- Occupational Pesticide Exposure of Parents and Brain Tumor Risk in ChildrenGreta Bunin; Fiscal Year: 2008..The proposed study will provide information on the usefulness of these approaches. [unreadable] [unreadable] [unreadable]..
- Pirfenidone in Children with PNs in NF1Roger Packer; Fiscal Year: 2006..Abstract Not Provided ..
- PATERNAL EXPOSURE AND SPORADIC BILATERAL RETINOBLASTOMAGreta Bunin; Fiscal Year: 2005..Sporadic heritable RBL is a childhood cancer worth studying in its own right and an ideal model for the investigation of new germline mutation. ..
- CHILDRENS NATIONAL MEDICAL CENTERRoger Packer; Fiscal Year: 2003....
- International Network and Registry for TMAHoward Trachtman; Fiscal Year: 2007..These include essential hypertension, diabetes, hyperlipidemia, myocardial infarction, and chronic kidney disease. [unreadable] [unreadable]..
- PREMATURE MENOPAUSE IN SURVIVORS OF CHILDHOOD CANCERCharles Sklar; Fiscal Year: 2002..The large size of the study population, the heterogeneity of diagnoses and exposures, combined with the extensive treatment data, will allow assessment of interaction between the major risk factors of interest. ..
- QUALITY OF LIFE FOLLOWING SUCCESSFUL THERAPY OF AMLHENRY NICHOLSON; Fiscal Year: 2001..Completion of this study should help pediatric oncologists fight AML in ways that optimize both survival and QOL. ..
- PEDIATRIC ONCOLOGY GROUP STUDIESThomas McLean; Fiscal Year: 2002....
- GENES INVOLVED IN AIDS LYMPHOMAGENESISMichael Teitell; Fiscal Year: 2002..Genes with significant involvement in the etiology and/or progression of lymphomagenesis, or those with reproducible in vitro biochemical effects, will be further characterized by molecular methods. ..
- Cellular Immunotherapy for Neuroblastoma With CTL clonesMichael Jensen; Fiscal Year: 2002..4.) To assess in this patient population the development of antibody and cellular immune responses against the scFvFc:zeta and HyTK chimeric proteins. ..
- Ethnic Differences in Survival after Childhood ALLSmita Bhatia; Fiscal Year: 2009..abstract_text> ..
- Control of Eye Melanoma MetastsisHans E Grossniklaus; Fiscal Year: 2010..The third aim determines the mechanism of combined angiostatin/IFN control of the micrometastases using methods in the first two aims. ..
- BONE MARROW TRANSPLANT (BMT) SURVIVORS STUDYSmita Bhatia; Fiscal Year: 2003..g., second cancers, births, cardiac complications, etc.) that may have occurred since the completion of the initial questionnaire. ..
- Vaso-occlusive Mechanisms that Induce Hypoxia and Cause Glioma Progression.Daniel J Brat; Fiscal Year: 2010..This proposal introduces entirely novel concepts that may explain the highly aggressive properties of GBM and suggests therapeutic approaches that could potentially stabilize its progression. ..
- COLLABORATIVE OCULAR MELANOMA STUDYFREDERICK DAVIDORF; Fiscal Year: 2003..Standardized clinical and data collection procedures will be employed, and standardized forms will be used in all centers. Central training and certification of all study staff will be required. ..
- Genetic Mutations in Gliomatosis CerebriMarcus Ware; Fiscal Year: 2004..We shall use this data to determine if there are specific patterns of chromosome aberrations that are characteristic of GC. Our final goal is to compare copy-number aberrations seen in GC to those seen in other non-GC astrocytic tumors. ..
- Development of an Aging and Cancer Program at MSKCCGeorge Bosl; Fiscal Year: 2007..Through this planning grant, MSKCC will formally expand its research activities in cancer biology and management in the aging population so that it will become a key component of its NCI-funded CCSG. ..
- GSK-3Beta and Associated Pathways in PNETCorey Raffel; Fiscal Year: 2004b>Primitive neuroectodermal tumors (PNET) are the most common malignant brain tumor of childhood. Using best available therapy, five-year survival for children with PNET is 60%...
- INVERSE METASTATIC MODALITIES BY HEPARANASESDario Marchetti; Fiscal Year: 2005..They will provide a framework for the development of polysaccharide-based anti-cancer molecules as important prognostic tools and diagnostic screens for metastatic detection, diagnosis and treatment. ..
- Imaging Kinase Activity In VivoWilliam Weiss; Fiscal Year: 2006..unreadable] [unreadable]..
- Glioma Immunotherapy Usingengineered T-CellsMichael Jensen; Fiscal Year: 2006..These data will form the basis for designing Phase I/II trials using enhanced T-cell dosing schedules, imaging techniques, and surrogate marker endpoints. ..
- MULTICENTER TRIAL OF SYNSORB PK IN E COLI RELATED HUSHoward Trachtman; Fiscal Year: 2003..The outcome of this trial may justify the use of SYNSORB PK as a safe therapy to ameliorate D+HUS. ..
- GENETICS OF A TRANSGENIC MOUSE MODEL FOR NEUROBLASTOMAWilliam Weiss; Fiscal Year: 2004..Given the poor outcome associated with childhood neuroblastoma, this work has the potential to increase our understanding of the pathogenesis of neuroblastoma, and may result in improved therapies for children with this disorder. ..
- SUBMACULAR SURGERY TRIALS PATHOLOGY CENTERHans Grossniklaus; Fiscal Year: 2003..Additionally, eyes obtained post-mortem from patients enrolled in the SST will be studied for pathologic correlation with clinical findings and outcomes. ..
- Novel Therapies for Resistant FSGSHoward Trachtman; Fiscal Year: 2006..The infrastructure that is established for the performance of this R21/R33 project should prove useful for the efficient assessment of additional novel therapies that will be developed in the future for patients with primary FSGS. ..
- Comparative DNA Microarray Analysis of Brain TumorsDaniel Brat; Fiscal Year: 2006....
- Control of Eye Melanoma MetastasisHans Grossniklaus; Fiscal Year: 2003..Both the IFN and angiostatin will prevent the progression of micrometastases into metastases by anti-angiogenesis. Angiostatin will prevent metastases by an anti-melanoma invasion effect. ..
- Intravascular Thrombosis in GlioblastomaDaniel Brat; Fiscal Year: 2005..Our emerging model represents a paradigm shift in the understanding of GBM and should lead directly to more effective therapies. ..
- OREGON CHILD HEALTH RESEARCH CENTERHENRY NICHOLSON; Fiscal Year: 2005..An effective formal educational program has been implemented and will be provided during the first two years of training for each Junior Investigator. ..
- Human monoclonal antibody therapy for HUSHoward Trachtman; Fiscal Year: 2004..abstract_text> ..