medulloblastoma

Summary

Summary: A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)

Top Publications

  1. pmc Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
    Trevor J Pugh
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nature 488:106-10. 2012
  2. pmc Novel mutations target distinct subgroups of medulloblastoma
    Giles Robinson
    St Jude Children s Research Hospital, Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA
    Nature 488:43-8. 2012
  3. pmc Medulloblastoma comprises four distinct molecular variants
    Paul A Northcott
    Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Oncol 29:1408-14. 2011
  4. pmc Molecular subgroups of medulloblastoma: the current consensus
    Michael D Taylor
    Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Acta Neuropathol 123:465-72. 2012
  5. pmc The genetic landscape of the childhood cancer medulloblastoma
    D Williams Parsons
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 331:435-9. 2011
  6. doi The clinical implications of medulloblastoma subgroups
    Paul A Northcott
    Division Molecular Genetics, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Nat Rev Neurol 8:340-51. 2012
  7. pmc Clonal selection drives genetic divergence of metastatic medulloblastoma
    Xiaochong Wu
    Arthur and Sonia Labatt Brain Tumour Research Center, Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Nature 482:529-33. 2012
  8. pmc Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome
    Yoon Jae Cho
    Children s Hospital Boston, Boston, MA 02115, USA
    J Clin Oncol 29:1424-30. 2011
  9. doi Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma
    Jason T Huse
    Departments of Pathology, 408 East 69th Street Z1304, New York, NY 10065, USA
    Nat Rev Cancer 10:319-31. 2010
  10. pmc Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features
    Marcel Kool
    Department of Human Genetics, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 3:e3088. 2008

Research Grants

  1. Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation
    Andrei L Gartel; Fiscal Year: 2013
  2. Nuclear IRS-1-DNA repair and mutagenesis in medulloblastoma
    Krzysztof Reiss; Fiscal Year: 2012
  3. Philip Reigan; Fiscal Year: 2014
  4. Reversible phosphorylation in Hedgehog signaling
    ALAN ZHU; Fiscal Year: 2013
  5. Development of sd-rxRNAs as Therapy for Retinoblastoma and Other Malignancies
    Pamela Pavco; Fiscal Year: 2012
  6. A high-throughput screen for small-molecule antagonists of Gli function
    James K Chen; Fiscal Year: 2012
  7. Epigenetic Regulation of Medulloblastoma
    LAURIE L JACKSON-GRUSBY; Fiscal Year: 2012
  8. Laura A Johnson; Fiscal Year: 2015
  9. SOMATIC CELL TRANSFER TO MODEL MEDULLOBLASTOMA IN MICE
    DANIEL WEBSTER FULTS; Fiscal Year: 2013
  10. Alexander Brown; Fiscal Year: 2014

Detail Information

Publications438 found, 100 shown here

  1. pmc Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
    Trevor J Pugh
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nature 488:106-10. 2012
    ..Recently, our group and others described distinct molecular subtypes of medulloblastoma on the basis of transcriptional and copy number profiles...
  2. pmc Novel mutations target distinct subgroups of medulloblastoma
    Giles Robinson
    St Jude Children s Research Hospital, Washington University Pediatric Cancer Genome Project, Memphis, Tennessee 38105, USA
    Nature 488:43-8. 2012
    b>Medulloblastoma is a malignant childhood brain tumour comprising four discrete subgroups. Here, to identify mutations that drive medulloblastoma, we sequenced the entire genomes of 37 tumours and matched normal blood...
  3. pmc Medulloblastoma comprises four distinct molecular variants
    Paul A Northcott
    Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Oncol 29:1408-14. 2011
    Recent genomic approaches have suggested the existence of multiple distinct subtypes of medulloblastoma. We studied a large cohort of medulloblastomas to determine how many subgroups of the disease exist, how they differ, and the extent ..
  4. pmc Molecular subgroups of medulloblastoma: the current consensus
    Michael D Taylor
    Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Acta Neuropathol 123:465-72. 2012
    b>Medulloblastoma, a small blue cell malignancy of the cerebellum, is a major cause of morbidity and mortality in pediatric oncology...
  5. pmc The genetic landscape of the childhood cancer medulloblastoma
    D Williams Parsons
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 331:435-9. 2011
    b>Medulloblastoma (MB) is the most common malignant brain tumor of children...
  6. doi The clinical implications of medulloblastoma subgroups
    Paul A Northcott
    Division Molecular Genetics, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Nat Rev Neurol 8:340-51. 2012
    b>Medulloblastoma, the most common malignant paediatric brain tumour, is currently diagnosed and stratified using a combination of clinical and demographic variables...
  7. pmc Clonal selection drives genetic divergence of metastatic medulloblastoma
    Xiaochong Wu
    Arthur and Sonia Labatt Brain Tumour Research Center, Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Nature 482:529-33. 2012
    b>Medulloblastoma, the most common malignant paediatric brain tumour, arises in the cerebellum and disseminates through the cerebrospinal fluid in the leptomeningeal space to coat the brain and spinal cord...
  8. pmc Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome
    Yoon Jae Cho
    Children s Hospital Boston, Boston, MA 02115, USA
    J Clin Oncol 29:1424-30. 2011
    ....
  9. doi Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma
    Jason T Huse
    Departments of Pathology, 408 East 69th Street Z1304, New York, NY 10065, USA
    Nat Rev Cancer 10:319-31. 2010
    ..The most common variants in the adult and paediatric populations - malignant glioma and medulloblastoma, respectively - have been the subject of increasingly intensive research over the past two decades that has ..
  10. pmc Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features
    Marcel Kool
    Department of Human Genetics, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 3:e3088. 2008
    b>Medulloblastoma is the most common malignant brain tumor in children. Despite recent improvements in cure rates, prediction of disease outcome remains a major challenge and survivors suffer from serious therapy-related side-effects...
  11. pmc A mouse model of the most aggressive subgroup of human medulloblastoma
    Daisuke Kawauchi
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Cancer Cell 21:168-80. 2012
    ..differs in its histopathology, gene expression profile, and clinical behavior from other forms of medulloblastoma. We generated a mouse model of MYC-subgroup medulloblastoma by transducing Trp53-null cerebellar progenitor ..
  12. pmc Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas
    Marcel Kool
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Acta Neuropathol 123:473-84. 2012
    b>Medulloblastoma is the most common malignant brain tumor in childhood. Molecular studies from several groups around the world demonstrated that medulloblastoma is not one disease but comprises a collection of distinct molecular subgroups...
  13. pmc Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
    Charles M Rudin
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA
    N Engl J Med 361:1173-8. 2009
    b>Medulloblastoma is the most common malignant brain tumor in children. Aberrant activation of the hedgehog signaling pathway is strongly implicated in the development of some cases of medulloblastoma...
  14. doi Hedgehog beyond medulloblastoma and basal cell carcinoma
    Stephan Teglund
    Department of Biosciences and Nutrition, Karolinska Institutet, SE 141 57 Huddinge, Sweden
    Biochim Biophys Acta 1805:181-208. 2010
    ..The Hh pathway is firmly linked to the etiology of basal cell carcinoma and to at least a subset of medulloblastoma. There is increasing evidence that other sporadic cancers, including those in pancreas, prostate, lung, and ..
  15. ncbi Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations
    Margaret C Thompson
    St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Clin Oncol 24:1924-31. 2006
    ..We hypothesized that gene expression profiling might be a more rapid and cost-effective method of identifying tumors that contain specific genetic abnormalities...
  16. pmc Subtypes of medulloblastoma have distinct developmental origins
    Paul Gibson
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
    Nature 468:1095-9. 2010
    b>Medulloblastoma encompasses a collection of clinically and molecularly diverse tumour subtypes that together comprise the most common malignant childhood brain tumour...
  17. pmc Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma
    Adrian M Dubuc
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada
    Acta Neuropathol 125:373-84. 2013
    Recent sequencing efforts have described the mutational landscape of the pediatric brain tumor medulloblastoma. Although MLL2 is among the most frequent somatic single nucleotide variants (SNV), the clinical and biological significance ..
  18. pmc Dual and opposing roles of primary cilia in medulloblastoma development
    Young Goo Han
    Department of Neurological Surgery and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research University of California San Francisco UCSF, California, USA
    Nat Med 15:1062-5. 2009
    ..We asked whether primary cilia in GNPs have a role in medulloblastoma growth in mice...
  19. ncbi Mutations in SUFU predispose to medulloblastoma
    Michael D Taylor
    Division of Neurosurgery, The Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Canada
    Nat Genet 31:306-10. 2002
    ..We report here that a subset of children with medulloblastoma carry germline and somatic mutations in SUFU (encoding the human suppressor of fused) of the SHH pathway, ..
  20. pmc The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma
    Tamar Uziel
    Department of Genetics and Tumor Cell Biology, Saint Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 106:2812-7. 2009
    ..Our findings suggest a functional collaboration between the miR-17 approximately 92 cluster and the SHH signaling pathway in the development of MBs in mouse and man...
  21. pmc Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables
    David W Ellison
    Department of Pathology MS 250, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    J Clin Oncol 29:1400-7. 2011
    ..Developing a practical therapeutic stratification that allows accurate identification of disease risk offers the potential to individualize adjuvant therapy and to minimize long-term adverse effects in a subgroup of survivors...
  22. pmc Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma
    Paul A Northcott
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
    Nat Genet 41:465-72. 2009
    ..oncogenes and focal deletions of 20 known tumor suppressor genes (TSG), most not previously implicated in medulloblastoma. Notably, we identified previously unknown amplifications and homozygous deletions, including recurrent, ..
  23. ncbi Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial
    Amar Gajjar
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet Oncol 7:813-20. 2006
    Current treatment for medulloblastoma, which includes postoperative radiotherapy and 1 year of chemotherapy, does not cure many children with high-risk disease...
  24. doi Universal poor survival in children with medulloblastoma harboring somatic TP53 mutations
    Uri Tabori
    Divisions of Haematology Oncology, The LabattBrain Tumor Research Centre, TheHospital for Sick Children, Toronto, Ontario, Canada
    J Clin Oncol 28:1345-50. 2010
    b>Medulloblastoma is the prototype of treatment success in modern pediatric neuro-oncology. Unfortunately, 20% to 30% of tumors recur despite maximal resection and multimodal therapy...
  25. pmc MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma
    Pasqualino De Antonellis
    Centro di Ingegneria Genetica e Biotecnologia Avanzate, CEINGE, Naples, Italy
    PLoS ONE 6:e24584. 2011
    ..Here, we have investigated medulloblastoma tumors (MBs), which arise from an early impairment of developmental processes in the cerebellum, where Notch ..
  26. pmc Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples
    Paul A Northcott
    The Arthur and Sonia Labatt Brain Tumour Research Center, Hospital for Sick Children, Toronto, ON, Canada
    Acta Neuropathol 123:615-26. 2012
    The diagnosis of medulloblastoma likely encompasses several distinct entities, with recent evidence for the existence of at least four unique molecular subgroups that exhibit distinct genetic, transcriptional, demographic, and clinical ..
  27. pmc The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors
    Paul A Northcott
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Program in Developmental and Stem Cell Biology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 69:3249-55. 2009
    b>Medulloblastoma is the most common malignant pediatric brain tumor, and mechanisms underlying its development are poorly understood...
  28. doi Minichromosome maintenance proteins 2, 3 and 7 in medulloblastoma: overexpression and involvement in regulation of cell migration and invasion
    K M Lau
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Oncogene 29:5475-89. 2010
    ..Functional roles beyond licensing are speculated. In addition, significances in medulloblastoma (MB) remain unclear...
  29. pmc Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups
    David W Ellison
    Department of Pathology MS 250, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Acta Neuropathol 121:381-96. 2011
    b>Medulloblastoma is heterogeneous, being characterized by molecular subgroups that demonstrate distinct gene expression profiles...
  30. ncbi Altered neural cell fates and medulloblastoma in mouse patched mutants
    L V Goodrich
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5427, USA
    Science 277:1109-13. 1997
    ..Mice heterozygous for the ptc mutation were larger than normal, and a subset of them developed hindlimb defects or cerebellar medulloblastomas, abnormalities also seen in BCNS patients...
  31. doi Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation
    Gianluca Canettieri
    Department of Experimental Medicine, Sapienza University, 324 Viale Regina Elena, 00161 Rome, Italy
    Nat Cell Biol 12:132-42. 2010
    Hedgehog signalling is crucial for development and is deregulated in several tumours, including medulloblastoma. Regulation of the transcriptional activity of Gli (glioma-associated oncogene) proteins, effectors of the Hedgehog pathway, ..
  32. pmc An animal model of MYC-driven medulloblastoma
    Yanxin Pei
    Tumor Development Program, NCI Designated Cancer Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Cancer Cell 21:155-67. 2012
    b>Medulloblastoma (MB) is the most common malignant brain tumor in children...
  33. ncbi Modeling radiation dosimetry to predict cognitive outcomes in pediatric patients with CNS embryonal tumors including medulloblastoma
    Thomas E Merchant
    Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 65:210-21. 2006
    ..Model the effects of radiation dosimetry on IQ among pediatric patients with central nervous system (CNS) tumors...
  34. doi MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma
    Sarra L Ryan
    Northern Institute for Cancer Research, Newcastle University, Sir James Spence Institute Level, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Acta Neuropathol 123:501-13. 2012
    The MYC oncogenes are the most commonly amplified loci in medulloblastoma, and have previously been proposed as biomarkers of adverse disease prognosis by us and others...
  35. pmc The micro-RNA 199b-5p regulatory circuit involves Hes1, CD15, and epigenetic modifications in medulloblastoma
    Immacolata Andolfo
    CEINGE, Biotecnologie Avanzate, Naples, Italy
    Neuro Oncol 14:596-612. 2012
    Micro-RNA (miR) 199b-5p targets Hes1 in medulloblastoma, one of the downstream effectors of both the canonical Notch and noncanonical Sonic Hedgehog pathways...
  36. pmc Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas
    Annette Künkele
    University Children s Hospital Essen, Pediatric Oncology, Essen, Germany
    Neuro Oncol 14:859-69. 2012
    ..medulloblastomas and normal cerebellum and assessed the mutational status of p53 and MDM2 expression in 6 medulloblastoma cell lines. MDM2 expression was elevated in medulloblastomas, compared with cerebellum...
  37. pmc Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics
    Xi Huang
    Howard Hughes Medical Institute, San Francisco, CA 94158, USA
    Genes Dev 26:1780-96. 2012
    b>Medulloblastoma (MB) is the most common pediatric CNS malignancy. We identify EAG2 as an overexpressed potassium channel in MBs across different molecular and histological subgroups...
  38. pmc The RNA-binding protein Musashi1 affects medulloblastoma growth via a network of cancer-related genes and is an indicator of poor prognosis
    Dat T Vo
    Greehey Children s Cancer Research Institute, University of Texas Health Science Center, San Antonio, USA
    Am J Pathol 181:1762-72. 2012
    ..We analyzed Msi1 expression in a large cohort of medulloblastoma samples and found that Msi1 is highly expressed in tumor tissue compared with normal cerebellum...
  39. doi Tis21 knock-out enhances the frequency of medulloblastoma in Patched1 heterozygous mice by inhibiting the Cxcl3-dependent migration of cerebellar neurons
    Stefano Farioli-Vecchioli
    Institute of Cell Biology and Neurobiology, National Research Council, Fondazione Santa Lucia, 00143 Rome, Italy
    J Neurosci 32:15547-64. 2012
    ..neuron precursor cells (GCPs), located in the external granular layer (EGL) of the cerebellum, gives rise to medulloblastoma. To investigate the process of neoplastic transformation of GCPs, we generated a new medulloblastoma model by ..
  40. ncbi Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma
    Roger J Packer
    Division of Neurology, Children s National Medical Center, Washington, DC 20010, USA
    J Clin Oncol 24:4202-8. 2006
    To determine the event-free survival (EFS) and overall survival of children with average-risk medulloblastoma and treated with reduced-dose craniospinal radiotherapy (CSRT) and one of two postradiotherapy chemotherapies.
  41. pmc Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells
    Elisabetta Ferretti
    Department of Experimental Medicine, Sapienza University, Roma, Italy
    EMBO J 27:2616-27. 2008
    ..granule cell progenitor development and a subversion of this pathway leads to neoplastic transformation into medulloblastoma (MB)...
  42. pmc YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation
    Africa Fernandez-L
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 23:2729-41. 2009
    b>Medulloblastoma is the most common solid malignancy of childhood, with treatment side effects reducing survivors' quality of life and lethality being associated with tumor recurrence...
  43. doi Expression of FoxM1 is required for the proliferation of medulloblastoma cells and indicates worse survival of patients
    Markus Priller
    Center for Neuropathology, Ludwig Maximilians University, Munich, Germany
    Clin Cancer Res 17:6791-801. 2011
    ..This study aimed to determine its role in medulloblastoma, the most frequent malignant brain tumor in childhood that can derive from cerebellar granule neuron ..
  44. pmc MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma
    Livia Garzia
    CEINGE, Centro di Ingegneria Genetica e Biotecnologia Avanzate, Naples, Italy
    PLoS ONE 4:e4998. 2009
    ..Here we have investigated medulloblastoma tumors (MBs), which arise from an early impairment of developmental processes in the cerebellum, where Notch ..
  45. ncbi Medulloblastoma: developmental mechanisms out of control
    Silvia Marino
    Institute of Clinical Pathology, University Hospital, Schmelzbergstrasse 12, 8091 Zurich, Switzerland
    Trends Mol Med 11:17-22. 2005
    b>Medulloblastoma, which is a highly aggressive central nervous system neoplasm, represents an intriguing example of how deregulated developmental mechanisms can lead to tumour development...
  46. ncbi Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo
    Lihua Yang
    Department of Pediatrics, and Neurology and Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Cancer Res 67:651-8. 2007
    ..These data indicate that the clinical evaluation of phosphodiesterase inhibitors in the treatment of patients with brain tumors is warranted...
  47. ncbi Response of preclinical medulloblastoma models to combination therapy with 13-cis retinoic acid and suberoylanilide hydroxamic acid (SAHA)
    Susan E Spiller
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Neurooncol 87:133-41. 2008
    Current medulloblastoma therapy, surgery, radiation, and chemotherapy, is unacceptably toxic...
  48. doi MicroRNA profiling in human medulloblastoma
    Elisabetta Ferretti
    Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
    Int J Cancer 124:568-77. 2009
    b>Medulloblastoma is an aggressive brain malignancy with high incidence in childhood. Current treatment approaches have limited efficacy and severe side effects...
  49. doi Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics
    Sarah Fattet
    INSERM U830, Laboratoire de Génétique et Biologie des Cancers, 75248 Paris Cedex 05, France
    J Pathol 218:86-94. 2009
    b>Medulloblastoma is the most frequent malignant paediatric brain tumour. The activation of the Wnt/beta-catenin pathway occurs in 10-15% of medulloblastomas and has been recently described as a marker for favourable patient outcome...
  50. doi High expression of stathmin protein predicts a fulminant course in medulloblastoma
    Meng Fai Kuo
    Division of Neurosurgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taiwan
    J Neurosurg Pediatr 4:74-80. 2009
    Stathmin, an important cytosolic phosphoprotein, is involved in cell proliferation and motility. This study was performed to elucidate the role of stathmin in the progression of medulloblastoma.
  51. doi Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis
    Stefan Rutkowski
    University Medical Center Hamburg Eppendorf, Department of Pediatric Hematology and Oncology, Hamburg, Germany
    J Clin Oncol 28:4961-8. 2010
    To assess the prognostic role of clinical parameters and histology in early childhood medulloblastoma.
  52. pmc p27(Kip1), a double-edged sword in Shh-mediated medulloblastoma: Tumor accelerator and suppressor
    Bobby Bhatia
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cell Cycle 9:4307-14. 2010
    b>Medulloblastoma, a brain tumor arising in the cerebellum, is the most common solid childhood malignancy. the current standard of care for medulloblastoma leaves survivors with life-long side effects...
  53. pmc Bortezomib induces apoptosis and growth suppression in human medulloblastoma cells, associated with inhibition of AKT and NF-ĸB signaling, and synergizes with an ERK inhibitor
    Fan Yang
    Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA
    Cancer Biol Ther 13:349-57. 2012
    b>Medulloblastoma is the most common brain tumor in children...
  54. doi Pleiotropic effects of miR-183~96~182 converge to regulate cell survival, proliferation and migration in medulloblastoma
    Shyamal Dilhan Weeraratne
    Department of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Acta Neuropathol 123:539-52. 2012
    ..To understand the contribution of miR-183~96~182 to the pathogenesis of this aggressive subtype of medulloblastoma, we analyzed global gene expression and proteomic changes that occur upon modulation of miRNAs in this ..
  55. pmc REST is a novel prognostic factor and therapeutic target for medulloblastoma
    Pete Taylor
    Department of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cancer Ther 11:1713-23. 2012
    b>Medulloblastoma is a malignant pediatric brain tumor. Current treatment following patient stratification into standard and high-risk groups using clinical features has improved survival...
  56. pmc Medulloblastoma exosome proteomics yield functional roles for extracellular vesicles
    Laura M Epple
    Department of Neurosurgery, Anschutz Medical Center, University of Colorado Denver, Aurora, Colorado, United States of America
    PLoS ONE 7:e42064. 2012
    ..extracellularly from cells after formation in, and transit thru, the endosomal pathway, may play roles in medulloblastoma pathogenesis but are as yet unstudied in this disease...
  57. pmc Silencing of the miR-17~92 cluster family inhibits medulloblastoma progression
    Brian L Murphy
    Authors Affiliations Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee Santaris Pharma, Hørsholm and Department of Haematology, Aalborg University Hospital, Copenhagen, Denmark
    Cancer Res 73:7068-78. 2013
    b>Medulloblastoma, originating in the cerebellum, is the most common malignant brain tumor in children...
  58. ncbi Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma
    H Hahn
    Institute of Pathology, TUM Technical University of Munich GSF Research Center of Environment and Health, Ingolstadter Landstrasse 1, 85758 Neuherberg, Federal Republic of Germany
    J Biol Chem 275:28341-4. 2000
    ..and Helman, L. (1999) Oncologist 4, 34-44), whereas medulloblastoma, a highly malignant tumor of the cerebellum, accounts for 20% of childhood brain tumors (Goodrich, L. V...
  59. pmc Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct
    Paul A Northcott
    The Arthur and Sonia Labatt Brain Tumour Research Center, Hospital for Sick Children, Toronto, ON, Canada
    Acta Neuropathol 122:231-40. 2011
    Recent integrative genomic approaches have defined molecular subgroups of medulloblastoma that are genetically and clinically distinct...
  60. ncbi Medulloblastoma: tumorigenesis, current clinical paradigm, and efforts to improve risk stratification
    William R Polkinghorn
    Massachusetts General Hospital, Boston, MA 02114, USA
    Nat Clin Pract Oncol 4:295-304. 2007
    b>Medulloblastoma is the most common brain malignancy in children and tremendous advances have recently been made in understanding the pathogenesis of this tumor...
  61. doi Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma
    Limei Zhou
    Sonia and Arthur Labatt Brain Tumor Research Centre, Hospital for Sick Children, University Avenue, Toronto, Ontario, Canada M5G 1X8
    Cancer Res 70:8199-210. 2010
    Mechanisms by which c-Myc (Myc) amplification confers aggressive medulloblastoma phenotypes are poorly defined...
  62. doi Downregulation of uPA/uPAR inhibits intermittent hypoxia-induced epithelial-mesenchymal transition (EMT) in DAOY and D283 medulloblastoma cells
    Reshu Gupta
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, Peoria, IL 61605, USA
    Int J Oncol 38:733-44. 2011
    ..hypoxia has a more pronounced effect than chronic hypoxia and contributes to EMT, invasion and migration in medulloblastoma cells. Intermittent hypoxia induced expression of mesenchymal markers (i.e...
  63. doi MicroRNA-21 suppression impedes medulloblastoma cell migration
    Eveline Grunder
    Oncology Department, University Children s Hospital of Zurich, Switzerland
    Eur J Cancer 47:2479-90. 2011
    b>Medulloblastoma (MB), the most common malignant brain tumour in children, is characterised by a high risk of leptomeningeal dissemination. But little is known about the molecular mechanisms that promote cancer cell migration in MB...
  64. doi Medulloblastoma
    Girish Dhall
    Children s Center for Cancer and Blood Diseases, Division of Pediatric Hematology Oncology, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    J Child Neurol 24:1418-30. 2009
    b>Medulloblastoma is the most common malignant brain tumor in children. Patients with medulloblastoma are stratified into ''standard'' and ''high'' risk categories based on age at diagnosis, degree of surgical resection, and disease spread...
  65. doi Radiobiological risk estimates of adverse events and secondary cancer for proton and photon radiation therapy of pediatric medulloblastoma
    N Patrik Brodin
    Radiation Medicine Research Center, Department of Radiation Oncology, Rigshospitalet, University of Copenhagen, Denmark
    Acta Oncol 50:806-16. 2011
    ..was to estimate and compare the risk of radiation-induced adverse late effects in pediatric patients with medulloblastoma (MB) treated with either three-dimensional conformal radiotherapy (3D CRT), inversely-optimized arc therapy (..
  66. pmc PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation
    Dannis G van Vuurden
    Department of Pediatric Oncology Hematology, Neuro oncology Research Group, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Oncotarget 2:984-96. 2011
    ..Aim of this study is to determine the radiosensitizing properties of the PARP inhibitor Olaparib in childhood medulloblastoma, ependymoma and high grade glioma (HGG)...
  67. ncbi Prediction of central nervous system embryonal tumour outcome based on gene expression
    Scott L Pomeroy
    Division of Neuroscience, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 415:436-42. 2002
    ..We show further that the clinical outcome of children with medulloblastomas is highly predictable on the basis of the gene expression profiles of their tumours at diagnosis...
  68. doi Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth
    Ninib Baryawno
    Childhood Cancer Research Unit, Department of Women s and Children s Health, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 70:266-76. 2010
    Activation of the beta-catenin and receptor kinase pathways occurs often in medulloblastoma, the most common pediatric malignant brain tumor...
  69. doi Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci
    Stefan Pfister
    Division of Molecular Genetics and Biostatistics and Clinical Cooperation Unit Neuropathology, German Cancer Research Center, Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany
    J Clin Oncol 27:1627-36. 2009
    b>Medulloblastoma is the most common malignant brain tumor in children. Current treatment decisions are based on clinical variables. Novel tumor-derived biomarkers may improve the risk stratification of medulloblastoma patients.
  70. doi Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas
    R Sutter
    Neuroscience Centre, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK
    Oncogene 29:1845-56. 2010
    ..Here, we describe a novel ontogenetic pathway of medulloblastoma that significantly contributes to understanding their heterogeneity...
  71. pmc PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
    Dolores Hambardzumyan
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 22:436-48. 2008
    ..These cellular characteristics are similar to human medulloblastomas. Finally, inhibition of Akt signaling sensitizes cells in the perivascular region to radiation-induced apoptosis...
  72. pmc siRNA-mediated downregulation of MMP-9 and uPAR in combination with radiation induces G2/M cell-cycle arrest in Medulloblastoma
    Ganji Purna Chandra Nagaraju
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, One Illini Drive, Peoria, IL 61605, USA
    Mol Cancer Res 9:51-66. 2011
    ..In this study, we evaluated the role of MMP-9 and uPAR in medulloblastoma cancer cell resistance to ionizing irradiation (IR) and tested the antitumor efficacy of siRNA (short ..
  73. ncbi Medulloblastoma growth inhibition by hedgehog pathway blockade
    David M Berman
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 297:1559-61. 2002
    ..we investigate the therapeutic efficacy of the Hh pathway antagonist cyclopamine in preclinical models of medulloblastoma, the most common malignant brain tumor in children...
  74. pmc Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma
    Yukiko Nakahara
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada
    Neoplasia 12:20-7. 2010
    Although medulloblastoma is the most common pediatric malignant brain tumor, its molecular underpinnings are largely unknown...
  75. pmc Integrated analysis of miRNA and mRNA expression in childhood medulloblastoma compared with neural stem cells
    Laura A Genovesi
    Brain Tumour Research Program, Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Australia
    PLoS ONE 6:e23935. 2011
    b>Medulloblastoma (MB) is the most common malignant brain tumor in children and a leading cause of cancer-related mortality and morbidity...
  76. ncbi Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastoma
    Wen Qing Yang
    Department of Oncology, University of Calgary and Tom Baker Cancer Centre, Calgary, Alberta, T2N 4N2 Canada
    Cancer Res 63:3162-72. 2003
    b>Medulloblastoma (MB), the most common pediatric brain tumor, is a highly malignant disease with a 5-year survival rate of only 60%...
  77. pmc Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain
    Jianping Wang
    The Scripps Research Institute, SP315, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    J Clin Invest 112:535-43. 2003
    ..but not GIFN/STAT1-null, transgenic mice, with CNS production of IFN-alpha, died prematurely with medulloblastoma. An immune response also induced in the brain of the GIFN/STAT2-/- mice was associated with IFN-gamma gene ..
  78. doi c-Myc and beta-catenin cooperate with loss of p53 to generate multiple members of the primitive neuroectodermal tumor family in mice
    H Momota
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Oncogene 27:4392-401. 2008
    ..These data provide insights into the biology and classification of human PNETs and suggest that multiple tumor types or variants can be generated from a fixed set of genetic abnormalities...
  79. pmc Amplification and overexpression of Hsa-miR-30b, Hsa-miR-30d and KHDRBS3 at 8q24.22-q24.23 in medulloblastoma
    Yuan Lu
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 4:e6159. 2009
    b>Medulloblastoma is the most common malignant brain tumour of childhood...
  80. pmc Treatment of medulloblastoma with a modified measles virus
    Adam W Studebaker
    The Center for Childhood Cancer, The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA
    Neuro Oncol 12:1034-42. 2010
    Although treatment of medulloblastoma has improved, at least 30% of patients with this tumor die of progressive disease. Unfortunately, many of the children who survive suffer long-term treatment-related morbidity...
  81. doi FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma
    Marc Remke
    German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Clin Oncol 29:3852-61. 2011
    Integrated genomics approaches have revealed at least four distinct biologic variants of medulloblastoma: WNT (wingless), SHH (sonic hedgehog), group C, and group D...
  82. pmc Development and cancer of the cerebellum
    Mary E Hatten
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, NY 10065, USA
    Trends Neurosci 34:134-42. 2011
    b>Medulloblastoma (MB) is the most common malignant pediatric brain tumor and is thought to arise from genetic anomalies in developmental pathways required for the normal maturation of the cerebellar cortex, notably developmental pathways ..
  83. pmc RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells
    Andre O Von Bueren
    Neuro Oncology Program, University Children s Hospital, Zurich, Switzerland
    BMC Cancer 9:10. 2009
    With current treatment strategies, nearly half of all medulloblastoma (MB) patients die from progressive tumors. Accordingly, the identification of novel therapeutic strategies remains a major goal...
  84. doi Direct orthotopic transplantation of fresh surgical specimen preserves CD133+ tumor cells in clinically relevant mouse models of medulloblastoma and glioma
    Qin Shu
    Laboratory of Molecular Neuro Oncology, Texas Children s Cancer Center, Texas Children s Hospital, 6621 Fannin St, MC 3 3320, Houston, Texas 77030, USA
    Stem Cells 26:1414-24. 2008
    Recent identification of cancer stem cells in medulloblastoma (MB) and high-grade glioma has stimulated an urgent need for animal models that will not only replicate the biology of these tumors, but also preserve their cancer stem cell ..
  85. pmc Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8
    Massimiliano De Bortoli
    Texas Children s Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    BMC Cancer 6:223. 2006
    b>Medulloblastoma is the most common malignant brain tumor of childhood...
  86. ncbi Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus
    J S Smith
    Division of Laboratory Genetics, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Genomics 59:97-101. 1999
    ..by direct sequencing in DNA extracted from 33 tumor samples with allelic loss of 17p13, including 10 medulloblastoma, 14 follicular thyroid cancer (FTC), and 9 ovarian cancer specimens. No mutations were identified...
  87. ncbi Correlation of neurosurgical subspecialization with outcomes in children with malignant brain tumors
    A L Albright
    Department of Neurosurgery, Children s Hospital of Pittsburgh, Pennsylvania, USA
    Neurosurgery 47:879-85; discussion 885-7. 2000
    ..This study was performed to evaluate the association between the type of neurosurgeon (general or pediatric) and either the extent of tumor removal or the frequency of complications in children undergoing malignant brain tumor resections...
  88. ncbi From the archives of the AFIP: medulloblastoma: a comprehensive review with radiologic-pathologic correlation
    Kelly K Koeller
    Department of Radiologic Pathology, Armed Forces Institute of Pathology, 14th St at Alaska Ave, Bldg 54, Washington, DC 20306 6000, USA
    Radiographics 23:1613-37. 2003
    b>Medulloblastoma is the most common pediatric central nervous system malignancy and the most common primary tumor of the posterior fossa in children...
  89. ncbi Investigation of human brain tumors for the presence of polyomavirus genome sequences by two independent laboratories
    Dana E M Rollison
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Int J Cancer 113:769-74. 2005
    ..Results for masked quality control tissues were concordant between laboratories. Nucleotide sequences for JCV, BKV and SV40 are rarely present in a large series of adult and pediatric brain tumors...
  90. ncbi Apurinic/apyrimidinic endonuclease activity is associated with response to radiation and chemotherapy in medulloblastoma and primitive neuroectodermal tumors
    Michael S Bobola
    Division of Neurosurgery, Department of Surgery, Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
    Clin Cancer Res 11:7405-14. 2005
    ....
  91. pmc Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
    Ryan B Corcoran
    Departments of Developmental Biology, Genetics, and Bioengineering, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305 5329, USA
    Proc Natl Acad Sci U S A 103:8408-13. 2006
    ..Errors in Shh signal transduction play important roles in the formation of human tumors, including medulloblastoma (MB)...
  92. pmc Childhood brain tumors: accomplishments and ongoing challenges
    Roger J Packer
    Division of Child Neurology, Center of Excellence for Neuroscience and Behavioral Medicine, Children s National Medical Center, Washington, DC 20010, USA
    J Child Neurol 23:1122-7. 2008
    ..Because of advances in our understanding of the biology underlying childhood brain tumors, treatments may change dramatically in the years ahead. Accordingly, survival rates may improve and long-term sequelae lessen...
  93. doi Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice
    Ines Ecke
    Institute of Human Genetics, University of Goettingen, Gottingen, Germany
    Cancer Res 69:887-95. 2009
    Patched (Ptch) heterozygous mice develop medulloblastoma (MB) and rhabdomyosarcoma (RMS) resembling the corresponding human tumors...
  94. pmc Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma
    Tracy Ann Read
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 15:135-47. 2009
    ..Here we show that tumors from a model of medulloblastoma, the Patched mutant mouse, are propagated not by CD133(+) cells but by cells expressing the progenitor ..
  95. doi Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells
    Maha H Elamin
    Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Mol Carcinog 49:302-14. 2010
    b>Medulloblastoma is an aggressive primary brain tumor that arises in the cerebellum of children and young adults...
  96. pmc OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas
    David C Adamson
    Department of Surgery, The Pediatric Brain Tumor Foundation Institute, and The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Veterans Affairs Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 70:181-91. 2010
    ..This gene is amplified and overexpressed in medulloblastoma cell lines, but the nature and extent of its genetic alterations in primary tumors have not been evaluated...
  97. pmc ERK activation of p21 activated kinase-1 (Pak1) is critical for medulloblastoma cell migration
    Liangping Yuan
    Aflac Center for Cancer and Blood Disorders, Emory University School of Medicine, Atlanta, GA 30322, USA
    Clin Exp Metastasis 27:481-91. 2010
    ..that overexpression of the platelet-derived growth factor receptor (PDGFR) is associated with metastatic medulloblastoma (MB) and showed that PDGF treatment increases ERK activity and promotes MB cell migration...
  98. doi Low-level copy number changes of MYC genes have a prognostic impact in medulloblastoma
    Karel Zitterbart
    Department of Pediatric Oncology, University Hospital Brno, Masaryk University, Cernopolni 9, 613 00 Brno, Czech Republic
    J Neurooncol 102:25-33. 2011
    High-level amplifications of MYC genes are associated with poor outcomes in childhood medulloblastoma (MB)...
  99. ncbi Treatment planning with protons for pediatric retinoblastoma, medulloblastoma, and pelvic sarcoma: how do protons compare with other conformal techniques?
    Catherine T Lee
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 63:362-72. 2005
    ....
  100. ncbi Stratification of medulloblastoma on the basis of histopathological grading
    Felice Giangaspero
    Department of Experimental Medicine and Pathology, University of Rome La Sapienza, 00151, Rome, Italy
    Acta Neuropathol 112:5-12. 2006
    b>Medulloblastoma (WHO grade IV) is an embryonal tumour of the cerebellum and the most common malignant central nervous system tumour in children...
  101. ncbi Medulloblastoma in childhood: new biological advances
    John R Crawford
    Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, Washington DC 20010, USA
    Lancet Neurol 6:1073-85. 2007
    b>Medulloblastoma is the most common embryonal tumour in children. Patients with medulloblastoma are currently staged as average-risk or poor-risk on the basis of clinical findings...

Research Grants71

  1. Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation
    Andrei L Gartel; Fiscal Year: 2013
    ..MMP-9) expression with survival and M-stage indicates that these proteases may modulate the survival of medulloblastoma patients...
  2. Nuclear IRS-1-DNA repair and mutagenesis in medulloblastoma
    Krzysztof Reiss; Fiscal Year: 2012
    ..Importantly, we have detected nuclear IRS-1 in medulloblastoma cell lines and in medulloblastoma clinical samples, which were positive for polyomavirus JC large T-antigen...
  3. Philip Reigan; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Medulloblastoma is the most common primary brain tumor in children...
  4. Reversible phosphorylation in Hedgehog signaling
    ALAN ZHU; Fiscal Year: 2013
    ..mitogenic activity has been associated with up to 25% of tumors in humans, including basal cell carcinoma and medulloblastoma. Therefore, studies of how Hh signaling is transduced would have widespread implications for our ..
  5. Development of sd-rxRNAs as Therapy for Retinoblastoma and Other Malignancies
    Pamela Pavco; Fiscal Year: 2012
    ..target for development because it drives tumorigenesis in diverse cancers, including neuroblastoma, medulloblastoma, and other CNS malignancies...
  6. A high-throughput screen for small-molecule antagonists of Gli function
    James K Chen; Fiscal Year: 2012
    ..Smo have demonstrated efficacy in mouse models of Hh pathway-dependent tumors, such as basal cell carcinoma, medulloblastoma, pancreatic adenocarcinoma, and prostate cancer...
  7. Epigenetic Regulation of Medulloblastoma
    LAURIE L JACKSON-GRUSBY; Fiscal Year: 2012
    The overarching goal of this project is to understand two important aspects of epigenetic control during medulloblastoma formation, namely the difference between cancer stem cells and bulk tumor, and the role of DNA methylation ..
  8. Laura A Johnson; Fiscal Year: 2015
    ..patients with GBM, this platform can readily be expanded to target antigens from other CNS cancers, such as medulloblastoma, within the Brain Tumor Center at Duke...
  9. SOMATIC CELL TRANSFER TO MODEL MEDULLOBLASTOMA IN MICE
    DANIEL WEBSTER FULTS; Fiscal Year: 2013
    ..Achievement of these aims will make it possible to translate the mechanistic discoveries to molecular targeted therapies for children with MB. ..
  10. Alexander Brown; Fiscal Year: 2014
    ..Chronic Hh pathway activation in GNPs leads to medulloblastoma (MB), the most common childhood malignant brain tumor...
  11. Ototoxicity protection with intratympanic steroid implant
    William H Slattery; Fiscal Year: 2012
    ..Cisplatin is commonly used for the treatment of a variety of cancers, including medulloblastoma, neuroblastoma, osteosarcoma, and testicular, ovarian, cervical, bladder, lung, and head and neck cancers and ..
  12. Role of genome organizer Satb1 in Shh-dependent proliferation and tumorigenesis
    FRANCES YUN CHENG; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Medulloblastoma, the most common malignant pediatric brain tumor, can result from disruption of the delicate balance between proliferation and differentiation in cerebellar granule neuron precursors (..
  13. MIM regulates Shh target gene expression in tumors
    SCOTT ATWOOD; Fiscal Year: 2011
    ..promotes growth and invasion of 25% of human cancers including lung, breast, prostate, pancreatic, as well as medulloblastoma and basal cell carcinoma...
  14. Wensheng Lin; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Medulloblastoma (MB) is a highly malignant pediatric brain tumor with a 5-year survival rate of ~ 60%...
  15. Hedgehog Pathway Blockade by Small-Molecule Gli Antagonists
    James K Chen; Fiscal Year: 2013
    ..have demonstrated efficacy in mouse models of Hh pathway-dependent tumors, including basal cell carcinoma, medulloblastoma, pancreatic adenocarcinoma, and prostate cancer...
  16. Cellular plasticity and survival mechanisms in medulloblastoma stem cells
    Ronnie Yoo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Medulloblastoma, the most common pediatric brain cancer, is a primitive neuroectodermal tumor (PNET) that arises in the cerebella...
  17. Brain Enriched MicroRNA 128a and 9/9+: Impact on medulloblastoma pathogenesis
    Rajeev Vibhakar; Fiscal Year: 2013
    ..b>Medulloblastoma is the most common malignant brain tumor of childhood with poor outcomes and significant therapy related ..
  18. Regulation of Hedgehog signaling at the level of Gli
    Jing Yang; Fiscal Year: 2013
    ..has severe consequences in humans, ranging from birth defects to the development of basal cell carcinoma, medulloblastoma, and many other tumors. Many human disease-associated mutations have been identified in Hh pathway components...
  19. Development of Novel Mouse Models to Study REST Function in Medulloblastoma
    Vidya Gopalakrishnan; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Medulloblastoma is the most common malignant pediatric brain tumor. Current treatments for this disease include surgery, cranio-spinal radiation and chemotherapy...
  20. Jianhang Jia; Fiscal Year: 2016
    ..HEALTH RELEVANCE Abnormal Smoothened (Smo) activation results cancers such as basal cell carcinoma (BCC) and medulloblastoma. Investigation of the Smo signaling mechanisms will provide both insights into fundamental developmental ..
  21. Dissecting the Roles of REST and Its Corepressor CoREST throughout Neural Develop
    Nurit Ballas; Fiscal Year: 2012
    ..Dysregulation of REST has been recently implicated in cancers in the nervous system (medulloblastoma) and outside the nervous system (epithelial cancers), as well as in neuronal death as a consequence of ..
  22. Anna Marie Kenney; Fiscal Year: 2016
    ..Current treatments for medulloblastoma, surgery, cranio-spinal radiation, and chemotherapy, leave survivors with life-long, devastating side effects...
  23. Victor E Velculescu; Fiscal Year: 2016
    ..genes in colorectal and breast cancers, ARID1A in ovarian clear cell carcinoma, chromatin remodeling genes in medulloblastoma, and NOTCH1 in head and neck cancers...
  24. Multifuctional Nanovector For Diagnosis And Treatment Of Pediatric Brain Cancer
    Miqin Zhang; Fiscal Year: 2010
    ..Like all cancers in brain, medulloblastoma are difficult to treat because of neurotoxicity, tumor resistance to foreign substances, and minimal delivery ..
  25. Vidya Gopalakrishnan; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Medulloblastoma is the most common malignant pediatric brain tumor...
  26. PROTON RADIATION THERAPY RESEARCH
    Thomas F DeLaney; Fiscal Year: 2013
    ..delivery techniques to improve outcome for patients with non-small cell lung cancer, liver tumors, pediatric medulloblastoma and rhabdomyosarcoma, spine/skull base sarcomas, and paranasal sinus malignancies...
  27. Oncolytic Virotherapy of Meningeal Cancer
    Matthias Gromeier; Fiscal Year: 2013
    ..We observed that the particular signaling environment in medulloblastoma, the most common pediatric CNS malignancy, enables rampant viral translation resulting in astounding ..
  28. Neutralizing Anti-HGF mAbs and CNS Malignancy
    John J Laterra; Fiscal Year: 2010
    ..HGF) is a promising therapeutic target for the most common primary CNS malignancies such as glioblastoma and medulloblastoma and brain metastases...
  29. Marina Pasca di Magliano; Fiscal Year: 2016
    ..target and new inhibitors of the pathway are currently been tested in the clinic for Basal Cell carcinoma and medulloblastoma. The inhibitors that are currently available block the pathway at the level of Smoothened, a transmembrane ..
  30. Suzanne J Baker; Fiscal Year: 2016
    ..to develop novel mouse models that provided key biological insights into cerebellar growth regulation and medulloblastoma development, used these models for relevant preclinical testing of new therapeutic agents, and translated ..
  31. A novel high content screen for regulators of ciliogenesis and Hedgehog signaling
    JEREMY F contact REITER; Fiscal Year: 2010
    ..Smoothened, mutations in which can cause basal cell carcinoma, the most common cancer in North America, and medulloblastoma, the most common solid cancer among children...
  32. STACEY KATHRYN OGDEN; Fiscal Year: 2016
    ..Inappropriate Hh signaling is causative in basal cell carcinoma, the most common cancer in humans, medulloblastoma, the most common malignant brain tumor in children, and rhabdomyosarcoma, where pathway activation correlates ..
  33. Regulation of medulloblastoma tumor growth by SPARC
    Sajani Lakka; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Medulloblastoma (MB) is the most common malignant brain tumor diagnosed in children...
  34. Diffusion Tensor Imaging to Define CNS Injury in Children with Brain Tumors
    MARY BARON NELSON; Fiscal Year: 2012
    ..children treated with high-dose chemotherapy with autologous hematopoietic progenitor cell rescue (AuHCR) for medulloblastoma or ependymoma will display key areas of white matter and gray matter injury from this treatment, which ..
  35. 'Exvading'Invasive Pediatric Brain Tumors
    Ravi V Bellamkonda; Fiscal Year: 2013
    ..b>Medulloblastoma migration and invasion along the leptomeningial pathway is facilitated by two elements: a) topographical cues ..
  36. Orchestration of breast cancer osteolytic bone metastasis by MIF
    Jessica M Grunda; Fiscal Year: 2013
    ..Utilizing an animal model of medulloblastoma bone metastasis generated by our laboratory as a 'discovery tool', macrophage migration inhibitory ..
  37. Timothy Gershon; Fiscal Year: 2015
    ..Specifically, Dr. Gershon will focus on the pathogenesis of medulloblastoma and the development of novel, biologically-based anti-tumor therapy. Dr...
  38. Maternal dietary folic acid and risk of medulloblastoma in a mouse model
    JULIE ANN contact ROSS; Fiscal Year: 2010
    ..suggests that prenatal vitamin supplementation may be protective for several childhood cancers, including medulloblastoma. Some evidence indicates that folic acid, a major component of prenatal vitamins, may be mediating the ..
  39. The Role of PDGFR in Medulloblastoma Progression
    Tobey J Macdonald; Fiscal Year: 2010
    b>Medulloblastoma is the most common malignant brain tumor in children. To approach the problem of effective therapy, the progression of human medulloblastoma must first be understood...
  40. Developmental Origins of Neural Tumors Using a Novel Genetic Inducible Analysis
    PRAVEEN B RAJU; Fiscal Year: 2013
    b>Medulloblastoma is a malignant brain tumor in children with significant mortality and poor outcomes secondary to toxicity of cun-ent therapy...
  41. Nanovectors For Brain Tumor Diagnosis And Treatment
    Miqin Zhang; Fiscal Year: 2011
    ..proposed research, the effectivity of the engineered nanovector will be demonstrated with the brain cancer, medulloblastoma. Brain tumor therapy is currently severely limited by the inability to non-invasively diagnose and stage ..
  42. Mycn and Medulloblastoma
    William A Weiss; Fiscal Year: 2013
    b>Medulloblastoma, a tumor of the central nervous system, is a common and frequently lethal tumor of childhood...
  43. Clinical pharmacology of cyclophosphamide in pediatric medulloblastoma patients
    Michael B Tagen; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Medulloblastoma and primitive neuroectodermal tumors (PNETs) are childhood brain tumors where about 40% of patients die due to early tumor recurrence...
  44. The Role of Caspase-8 in Neuroblastoma Tumorigenesis
    GERARD PAUL ZAMBETTI; Fiscal Year: 2013
    ..In addition, since loss of C8 has been correlated with poor prognosis in medulloblastoma and with relapsed aggressive glioblastoma, which also exhibit N-myc amplification and/or overexpression, the ..
  45. The Role of OTX2 in Molecular Pathogenesis of Medulloblastoma
    Hai Yan; Fiscal Year: 2010
    Molecular-targeted therapies are within reach of 21st century cancer medicine. Although medulloblastoma is the most common malignant brain tumor of childhood, the identity of molecules that are useful therapeutic targets in ..
  46. REST/NRSF-mediated medulloblastoma tumorigenesis
    Sadhan Majumder; Fiscal Year: 2013
    b>Medulloblastoma (MB) is among the most malignant of pediatric brain tumors, having an average 5-year survival rate of only 50%...
  47. Edward A Neuwelt; Fiscal Year: 2014
    ..revised proposal, we will assess the potential for enhancing chemotherapy dose intensity for intracerebral medulloblastoma as a model of primitive neuroectodermal tumors within brain parenchyma, by using BBBD and by depleting ..
  48. Roles for HIC1 in neural development and tumor suppression
    DAVID NEIL WATKINS; Fiscal Year: 2010
    ..HIC1 has emerged as a potential important tumor suppressor in medulloblastoma, a primitive embryonal tumor arising from the granule cell precursors of the cerebellum which serves as an ..
  49. REGULATION OF CNS AND LIMB POLARITY BY SONIC HEDGEHOG
    Andrew P McMahon; Fiscal Year: 2011
    ..of several types of tumor, most notably basal cell carcinoma (BCC) (the most common form of skin cancer), medulloblastoma (the most common brain tumor of children) and rhabdomyosarcoma (the most prevalent soft tissue cancer in ..
  50. Stem Cells, Progenitors, and the Origin of Medulloblastoma
    Robert J Wechsler-Reya; Fiscal Year: 2013
    b>Medulloblastoma is the most common malignant brain tumor in children. Almost half the children who develop medulloblastoma die from it, and survivors often develop severe side effects as a result of the treatment...
  51. Rakesh K Jain; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Medulloblastoma (MB) is the most common malignant pediatric brain tumor...
  52. Prediction of Second Cancer Risks for Children Treated with Proton - vs. - Photon
    Wayne D Newhauser; Fiscal Year: 2010
    ..of second cancers that develop in the breast and thyroid of children treated for Hodgkin's disease and medulloblastoma, respectively...
  53. William A Weiss; Fiscal Year: 2014
    ..b>Medulloblastoma (MB) is the most common pediatric brain tumor...
  54. Jeremy F Reiter; Fiscal Year: 2016
    ..Smoothened, mutations in which can cause basal cell carcinoma, the most common cancer in North America, and medulloblastoma, the most common solid cancer among children...
  55. P3IK Signaling and Biology of Therapeutic Response in Brain and Prostate Tumors
    Eric C Holland; Fiscal Year: 2013
    ..three tumor types where the PI3K pathway contributes to oncogenesis and therapeutic resistance, namely medulloblastoma, glioma, and prostate cancer...
  56. Cellular and Molecular Requirements for Medulloblastoma Tumorigenesis
    Desmond A Brown; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Medulloblastoma (MB) is a neuroepithelial tumor of the cerebellum and is the most common central nervous system (CNS) malignancy in children...
  57. PACAP Modulation of Shh Signaling in Medulloblastoma
    Linda M Liau; Fiscal Year: 2010
    ..patched-1 heterozygotes (Ptc+/'), as Ptd^'PACAP*''double heterozygous (DH) mice have a medulloblastoma incidence of 66% (compared to only 15% in Ptc+/~ mice)...
  58. William A Weiss; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Medulloblastoma is a common and disabling tumor of children, for which current therapies are often ineffective...
  59. The essential role of supporting cells in medulloblastoma tumorigenicity
    PATRICK BRITTEN VENTURA; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Medulloblastoma is the most common pediatric malignant brain tumor...
  60. Sanjiv S Gambhir; Fiscal Year: 2014
    ..One of the four research projects validates image-guided resection to improve outcomes for children with medulloblastoma. Another research project develops new strategies for enzyme-activated PET and MRI imaging agents...
  61. Identification of a Mitogen for Neuronal Progenitors in the Embryonic Cerebellum
    Robert J Wechsler Reya; Fiscal Year: 2010
    ..of cerebellar circuitry and are thought to represent the cell of origin for the pediatric brain tumor medulloblastoma. While the development of granule neurons has been studied in detail, the signals that control their growth ..
  62. James M Olson; Fiscal Year: 2015
    ..aims are 1) To assess the efficacy of Cdk 4/6 inhibition in clinically relevant mouse models of ATRT and medulloblastoma;2) To identify novel therapeutic targets in infant and toddler brain tumors;3) To advance one highly ..
  63. MOLECULAR MARKERS OF PROGNOSIS IN MEDULLOBLASTOMA
    SANDRA BIGNER; Fiscal Year: 2000
    DESCRIPTION: (Applicant's Abstract) Medulloblastoma, the most common malignant central nervous system neoplasm in children, has a dismal prognosis despite multi-institutional clinical trials using increasingly sophisticated neurosurgical ..
  64. Human Neurotropic JC Virus and CNS Diseases
    Kamel Khalili; Fiscal Year: 2006
    ..animals that develop cerebellar primitive neuroectodermal tumors with extraordinary similarity to human medulloblastoma. Results from genetic and biochemical studies have revealed that while in some cells T-antigens is expressed ..
  65. MIBG ANALOGUE RADIOPHARMACEUTICALS
    Ganesan Vaidyanathan; Fiscal Year: 2001
    ..effect of several pharmacological agents will be studied using a panel of neuroblastoma, pheochromocytoma and medulloblastoma cell lines...
  66. Imaging of O6-Alkylguanine-DNA Alkyltransferase
    Ganesan Vaidyanathan; Fiscal Year: 2005
    ..Primarily, TE-67 1 human medulloblastoma xenografts will be utilized for these studies...
  67. Astatine 211 & Radioiodine Labeled Octreotide Conjugates
    Michael Zalutsky; Fiscal Year: 2004
    ..of radiohalogenated octreotide conjugates and related peptides as radiodiagnostics and therapeutics for medulloblastoma. Recent studies have demonstrated that the concentratior of sst2 on human medulloblastoma is extremely high, ..
  68. Phase I Trial of 90Y Octreotide in Childhood Solid Tumor
    M O DORISIO; Fiscal Year: 2002
    ..and from other investigators has established the expression of somatostatin receptors in neuroblastoma, medulloblastoma, the Ewing's sarcoma family of tumors and osteogenic sarcoma...
  69. CELL DEATH AND DIFFERENTIATION IN MEDULLOBLASTOMA
    John Trojanowski; Fiscal Year: 1999
    ..These studies also will clarify the role that neurotrophins play in the emergence and progression of MBs and PNBTs. Insights into these basic biological processes could set the stage for the development of novel gene therapies for MBs. ..