glioblastoma

Summary

Summary: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.

Top Publications

  1. pmc miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells
    Joachim Silber
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
    BMC Med 6:14. 2008
  2. pmc Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    Roel G W Verhaak
    The Eli and Edythe L Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA
    Cancer Cell 17:98-110. 2010
  3. ncbi Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    Roger Stupp
    Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    N Engl J Med 352:987-96. 2005
  4. ncbi Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    Shideng Bao
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 444:756-60. 2006
  5. ncbi Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    Roger Stupp
    Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Lancet Oncol 10:459-66. 2009
  6. pmc An integrated genomic analysis of human glioblastoma multiforme
    D Williams Parsons
    Ludwig Center for Cancer Genetics and Therapeutics, and Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 321:1807-12. 2008
  7. ncbi Identification of a cancer stem cell in human brain tumors
    Sheila K Singh
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Cancer Res 63:5821-8. 2003
  8. pmc IDH1 and IDH2 mutations in gliomas
    Hai Yan
    Department of Pathology, Pediatric Brain Tumor Foundation Institute, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 360:765-73. 2009
  9. ncbi MGMT gene silencing and benefit from temozolomide in glioblastoma
    Monika E Hegi
    Laboratory of Tumor Biology and Genetics, Department of Neurosurgery, University Hospital Lausanne, Lausanne, Switzerland
    N Engl J Med 352:997-1003. 2005
  10. pmc A restricted cell population propagates glioblastoma growth after chemotherapy
    Jian Chen
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
    Nature 488:522-6. 2012

Detail Information

Publications320 found, 100 shown here

  1. pmc miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells
    Joachim Silber
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
    BMC Med 6:14. 2008
    b>Glioblastoma multiforme (GBM) is an invariably fatal central nervous system tumor despite treatment with surgery, radiation, and chemotherapy...
  2. pmc Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    Roel G W Verhaak
    The Eli and Edythe L Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA
    Cancer Cell 17:98-110. 2010
    The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM)...
  3. ncbi Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    Roger Stupp
    Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    N Engl J Med 352:987-96. 2005
    b>Glioblastoma, the most common primary brain tumor in adults, is usually rapidly fatal. The current standard of care for newly diagnosed glioblastoma is surgical resection to the extent feasible, followed by adjuvant radiotherapy...
  4. ncbi Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    Shideng Bao
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 444:756-60. 2006
    Ionizing radiation represents the most effective therapy for glioblastoma (World Health Organization grade IV glioma), one of the most lethal human malignancies, but radiotherapy remains only palliative because of radioresistance...
  5. ncbi Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    Roger Stupp
    Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Lancet Oncol 10:459-66. 2009
    ..Institute of Canada Clinical Trials Group (NCIC) reported improved median and 2-year survival for patients with glioblastoma treated with concomitant and adjuvant temozolomide and radiotherapy...
  6. pmc An integrated genomic analysis of human glioblastoma multiforme
    D Williams Parsons
    Ludwig Center for Cancer Genetics and Therapeutics, and Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 321:1807-12. 2008
    b>Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer...
  7. ncbi Identification of a cancer stem cell in human brain tumors
    Sheila K Singh
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Cancer Res 63:5821-8. 2003
    ..The identification of a BTSC provides a powerful tool to investigate the tumorigenic process in the central nervous system and to develop therapies targeted to the BTSC...
  8. pmc IDH1 and IDH2 mutations in gliomas
    Hai Yan
    Department of Pathology, Pediatric Brain Tumor Foundation Institute, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 360:765-73. 2009
    ....
  9. ncbi MGMT gene silencing and benefit from temozolomide in glioblastoma
    Monika E Hegi
    Laboratory of Tumor Biology and Genetics, Department of Neurosurgery, University Hospital Lausanne, Lausanne, Switzerland
    N Engl J Med 352:997-1003. 2005
    ..silencing of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene by promoter methylation compromises DNA repair and has been associated with longer survival in patients with glioblastoma who receive alkylating agents.
  10. pmc A restricted cell population propagates glioblastoma growth after chemotherapy
    Jian Chen
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
    Nature 488:522-6. 2012
    b>Glioblastoma multiforme is the most common primary malignant brain tumour, with a median survival of about one year. This poor prognosis is due to therapeutic resistance and tumour recurrence after surgical removal...
  11. pmc An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    Ittai Ben-Porath
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:499-507. 2008
    ....
  12. pmc Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    Johan Skog
    Department of Neurology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Nat Cell Biol 10:1470-6. 2008
    b>Glioblastoma tumour cells release microvesicles (exosomes) containing mRNA, miRNA and angiogenic proteins. These microvesicles are taken up by normal host cells, such as brain microvascular endothelial cells...
  13. pmc Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
    Houtan Noushmehr
    USC Epigenome Center, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Cell 17:510-22. 2010
    We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA)...
  14. ncbi Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma
    Dominik Sturm
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ Heidelberg, 69120 Heidelberg, Germany
    Cancer Cell 22:425-37. 2012
    b>Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays considerable heterogeneity. We have recently identified recurrent H3F3A mutations affecting two critical amino acids (K27 and G34) of histone H3...
  15. ncbi Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
    Jeremy Schwartzentruber
    McGill University and Genome Quebec Innovation Centre, Montreal, Quebec H3A 1A4, Canada
    Nature 482:226-31. 2012
    b>Glioblastoma multiforme (GBM) is a lethal brain tumour in adults and children. However, DNA copy number and gene expression signatures indicate differences between adult and paediatric cases...
  16. pmc The somatic genomic landscape of glioblastoma
    Cameron W Brennan
    Human Oncology and Pathogenesis Program, Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, Department of Neurological Surgery, Weill Cornell Medical Center, New York, NY 10065, USA Electronic address
    Cell 155:462-77. 2013
    ..of somatic genomic alterations based on multidimensional and comprehensive characterization of more than 500 glioblastoma tumors (GBMs)...
  17. ncbi Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
    Jeongwu Lee
    Neuro Oncology Branch, National Cancer Institute, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Cell 9:391-403. 2006
    ..These findings suggest that TSCs may be a more reliable model than many commonly utilized cancer cell lines for understanding the biology of primary human tumors...
  18. ncbi Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
    Rossella Galli
    Stem Cell Research Institute and Laboratory of Molecular Diagnostics, H S Raffaele, Milan, Italy
    Cancer Res 64:7011-21. 2004
    ..We report that, unlike other brain cancers, the lethal glioblastoma multiforme contains neural precursors endowed with all of the critical features expected from neural stem cells...
  19. pmc Emerging insights into the molecular and cellular basis of glioblastoma
    Gavin P Dunn
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Genes Dev 26:756-84. 2012
    b>Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive multiplatform genomic characterization has provided a higher-resolution picture of the molecular alterations underlying this disease...
  20. ncbi PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    J Li
    Department of Pathology, College of Physicians and Surgeons, Columbia University, 630 West 168 Street, New York, NY 10032, USA
    Science 275:1943-7. 1997
    ..In preliminary screens, mutations of PTEN were detected in 31% (13/42) of glioblastoma cell lines and xenografts, 100% (4/4) of prostate cancer cell lines, 6% (4/65) of breast cancer cell lines and ..
  21. ncbi Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
    Lucia Ricci-Vitiani
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy
    Nature 468:824-8. 2010
    b>Glioblastoma is a highly angiogenetic malignancy, the neoformed vessels of which are thought to arise by sprouting of pre-existing brain capillaries...
  22. ncbi High frequency of mutations of the PIK3CA gene in human cancers
    Yardena Samuels
    Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA
    Science 304:554. 2004
  23. ncbi Glioblastoma stem-like cells give rise to tumour endothelium
    Rong Wang
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nature 468:829-33. 2010
    b>Glioblastoma (GBM) is among the most aggressive of human cancers. A key feature of GBMs is the extensive network of abnormal vasculature characterized by glomeruloid structures and endothelial hyperplasia...
  24. pmc Uncovering MicroRNA and Transcription Factor Mediated Regulatory Networks in Glioblastoma
    Jingchun Sun
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS Comput Biol 8:e1002488. 2012
    b>Glioblastoma multiforme (GBM) is the most common and lethal brain tumor in humans...
  25. pmc Transforming fusions of FGFR and TACC genes in human glioblastoma
    Devendra Singh
    Institute for Cancer Genetics, Columbia University Medical Center, New York, NY, USA
    Science 337:1231-5. 2012
    The brain tumor glioblastoma multiforme (GBM) is among the most lethal forms of human cancer. Here, we report that a small subset of GBMs (3...
  26. pmc Consensus on the role of human cytomegalovirus in glioblastoma
    Kristine Dziurzynski
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 1400 Holcombe Blvd, Unit 442, Houston, TX 77030, USA
    Neuro Oncol 14:246-55. 2012
    ..In summary, existing evidence supports an oncomodulatory role for HCMV in malignant gliomas, but future studies need to focus on determining the role of HCMV as a glioma-initiating event...
  27. ncbi Extensive modulation of a set of microRNAs in primary glioblastoma
    S A Ciafrè
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Roma, Italy
    Biochem Biophys Res Commun 334:1351-8. 2005
    ..In our study, we examined by microarray the global expression levels of 245 microRNAs in glioblastoma multiforme, the most frequent and malignant of primary brain tumors...
  28. ncbi Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
    Shideng Bao
    Department of Surgery, Preston Robert Tisch Brain Tumor Center, Molecular Cancer Biology Program, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Res 66:7843-8. 2006
    ..SCLGC isolated from human glioblastoma biopsy specimens and xenografts potently generated tumors when implanted into the brains of immunocompromised ..
  29. pmc AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    Tracy T Batchelor
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cancer Cell 11:83-95. 2007
    Using MRI techniques, we show here that normalization of tumor vessels in recurrent glioblastoma patients by daily administration of AZD2171-an oral tyrosine kinase inhibitor of VEGF receptors-has rapid onset, is prolonged but reversible, ..
  30. pmc An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma
    Pavel Sumazin
    Columbia Initiative in Systems Biology, Columbia University, New York, NY 10032, USA
    Cell 147:370-81. 2011
    By analyzing gene expression data in glioblastoma in combination with matched microRNA profiles, we have uncovered a posttranscriptional regulation layer of surprising magnitude, comprising more than 248,000 microRNA (miR)-mediated ..
  31. ncbi Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
    Henry S Friedman
    Brain Tumor Center, Duke University, Durham, NC 27710, USA
    J Clin Oncol 27:4733-40. 2009
    We evaluated the efficacy of bevacizumab, alone and in combination with irinotecan, in patients with recurrent glioblastoma in a phase II, multicenter, open-label, noncomparative trial.
  32. ncbi Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
    S G M Piccirillo
    Department of Biotechnology and Biosciences, University of Milan Bicocca, 20126 Milan, Italy
    Nature 444:761-5. 2006
    ....
  33. ncbi MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
    Jennifer A Chan
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 65:6029-33. 2005
    ..Here we show that the highly malignant human brain tumor, glioblastoma, strongly over-expresses a specific miRNA, miR-21...
  34. pmc Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma
    Gentao Liu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, CA, 90048, USA
    Mol Cancer 5:67. 2006
    ..Some evidence has suggested that CD133 is a marker for a subset of leukemia and glioblastoma cancer stem cells...
  35. ncbi Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    P A Steck
    Department of Neuro Oncology, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Nat Genet 15:356-62. 1997
    Deletions involving regions of chromosome 10 occur in the vast majority (> 90%) of human glioblastoma multiformes...
  36. pmc HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
    Rose Du
    Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cancer Cell 13:206-20. 2008
    ..F4/80+ subpopulations, as well as endothelial and pericyte progenitor cells to promote neovascularization in glioblastoma. MMP-9 activity of bone marrow-derived CD45+ cells is essential and sufficient to initiate angiogenesis by ..
  37. pmc Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma
    Erwin G Van Meir
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA
    CA Cancer J Clin 60:166-93. 2010
    Malignant gliomas are the most common and deadly brain tumors. Nevertheless, survival for patients with glioblastoma, the most aggressive glioma, although individually variable, has improved from an average of 10 months to 14 months after ..
  38. ncbi Genetic pathways to glioblastoma: a population-based study
    Hiroko Ohgaki
    International Agency for Research on Cancer, Lyon, France
    Cancer Res 64:6892-9. 2004
    ..0208). This suggests that the acquisition of TP53 mutations in these glioblastoma subtypes occurs through different mechanisms.
  39. pmc MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes
    Yunqing Li
    Departments of Microbiology, Neurology and Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Cancer Res 69:7569-76. 2009
    ..Analysis of human specimens showed that miR-34a expression is down-regulated in glioblastoma tissues as compared with normal brain and in mutant p53 gliomas as compared with wild-type p53 gliomas...
  40. ncbi Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma
    Matija Snuderl
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cancer Cell 20:810-7. 2011
    ..The stable coexistence of different clones within the same tumor will have important clinical implications for tumor resistance to targeted therapies...
  41. pmc Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
    Andrea Sottoriva
    Department of Oncology, University of Cambridge, Cambridge CB2 2XZ, United Kingdom
    Proc Natl Acad Sci U S A 110:4009-14. 2013
    b>Glioblastoma (GB) is the most common and aggressive primary brain malignancy, with poor prognosis and a lack of effective therapeutic options...
  42. ncbi Astrocytes and Glioblastoma cells release exosomes carrying mtDNA
    Michele Guescini
    Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy
    J Neural Transm 117:1-4. 2010
    ..The present paper, for the first time, provides evidence that Glioblastoma and Astrocyte cells release microvesicles, which carry mitochondrial DNA (mtDNA)...
  43. pmc Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells
    Genevieve L Weber
    Ludwig Collaborative Laboratory, Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Oncotarget 2:833-49. 2011
    b>Glioblastoma multiforme (GBM) is a highly invasive and deadly brain tumor. Tumor cell invasion makes complete surgical resection impossible and reduces the efficacy of other therapies...
  44. ncbi Glioblastoma and other malignant gliomas: a clinical review
    Antonio Omuro
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York
    JAMA 310:1842-50. 2013
    ..26 per 100,000 population or 17,000 new diagnoses per year. These tumors are typically associated with a dismal prognosis and poor quality of life...
  45. pmc Chemoresistance of glioblastoma cancer stem cells--much more complex than expected
    Dagmar Beier
    Department of Neurology, RWTH Aachen, Medical School, Pauwelsstrasse 30, 52074 Aachen, Germany
    Mol Cancer 10:128. 2011
    ..Thus, the interaction of CSC and chemotherapy is more complex than may be expected and it is necessary to consider these factors in order to overcome chemoresistance in the patient...
  46. pmc Genetic pathways to primary and secondary glioblastoma
    Hiroko Ohgaki
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Am J Pathol 170:1445-53. 2007
    b>Glioblastoma is the most frequent and most malignant human brain tumor. The prognosis remains very poor, with most patients dying within 1 year after diagnosis...
  47. ncbi microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma
    Benjamin Kefas
    Division of Neuro Oncology, Neurology Department, University of Virginia Health System, Charlottesville, Virginia, USA
    Cancer Res 68:3566-72. 2008
    ..We show that microRNA-7 (miR-7) is a potential tumor suppressor in glioblastoma targeting critical cancer pathways...
  48. pmc Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma
    Olivier Keunen
    Norlux Neuro Oncology Laboratory, Oncology Department, Centre de Recherche Public de la Santé, 1526 Luxembourg, Luxembourg
    Proc Natl Acad Sci U S A 108:3749-54. 2011
    ..an antibody against vascular endothelial growth factor (VEGF), is a promising, yet controversial, drug in human glioblastoma treatment (GBM). Its effects on tumor burden, recurrence, and vascular physiology are unclear...
  49. pmc VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex
    Kan V Lu
    Department of Neurological Surgery, University of California, Helen Diller Family Cancer Research Center, San Francisco, CA 94143, USA
    Cancer Cell 22:21-35. 2012
    Inhibition of VEGF signaling leads to a proinvasive phenotype in mouse models of glioblastoma multiforme (GBM) and in a subset of GBM patients treated with bevacizumab...
  50. pmc Automated network analysis identifies core pathways in glioblastoma
    Ethan Cerami
    Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 5:e8918. 2010
    b>Glioblastoma multiforme (GBM) is the most common and aggressive type of brain tumor in humans and the first cancer with comprehensive genomic profiles mapped by The Cancer Genome Atlas (TCGA) project...
  51. ncbi Bevacizumab plus irinotecan in recurrent glioblastoma multiforme
    James J Vredenburgh
    Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 25:4722-9. 2007
    The prognosis for patients with recurrent glioblastoma multiforme is poor, with a median survival of 3 to 6 months...
  52. ncbi MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells
    Thales Papagiannakopoulos
    Department of Molecular, Cellular and Developmental Biology, Neuroscience Research Institute, University of California, Santa Barbara, California 93106, USA
    Cancer Res 68:8164-72. 2008
    ..Down-regulation of miR-21 in glioblastoma cells leads to derepression of these pathways, causing repression of growth, increased apoptosis, and cell ..
  53. pmc Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response
    Nicholas J Szerlip
    Department of Neurosurgery, Wayne State University Medical School, Detroit, MI 48201, USA
    Proc Natl Acad Sci U S A 109:3041-6. 2012
    b>Glioblastoma (GBM) is distinguished by a high degree of intratumoral heterogeneity, which extends to the pattern of expression and amplification of receptor tyrosine kinases (RTKs)...
  54. pmc Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma
    Peter W Lewis
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA
    Science 340:857-61. 2013
    ..We propose that K-to-M substitutions may represent a mechanism to alter epigenetic states in a variety of pathologies...
  55. ncbi MiR-195, miR-196b, miR-181c, miR-21 expression levels and O-6-methylguanine-DNA methyltransferase methylation status are associated with clinical outcome in glioblastoma patients
    Radek Lakomy
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Cancer Sci 102:2186-90. 2011
    b>Glioblastoma multiforme (GBM) is the most frequently occurring primary malignant brain tumor; patients with GBM often have a very poor prognosis and differing responses to treatment...
  56. pmc Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
    Zhizhong Li
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 15:501-13. 2009
    ..Our results demonstrate that GSCs differentially respond to hypoxia with distinct HIF induction patterns, and HIF2alpha might represent a promising target for antiglioblastoma therapies...
  57. pmc Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth
    Lin Cheng
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell 153:139-52. 2013
    ..Thus, GSCs contribute to vascular pericytes that may actively remodel perivascular niches. Therapeutic targeting of GSC-derived pericytes may effectively block tumor progression and improve antiangiogenic therapy...
  58. ncbi Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
    J Holash
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Science 284:1994-8. 1999
    ....
  59. pmc Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations
    Cameron Brennan
    Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    PLoS ONE 4:e7752. 2009
    b>Glioblastoma multiforme (GBM) is an umbrella designation that includes a heterogeneous group of primary brain tumors...
  60. pmc Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma
    Krishna P L Bhat
    Department of Pathology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA Electronic address
    Cancer Cell 24:331-46. 2013
    Despite extensive study, few therapeutic targets have been identified for glioblastoma (GBM)...
  61. ncbi Analysis of the IDH1 codon 132 mutation in brain tumors
    Jörg Balss
    Clinical Cooperation Unit Neuropathology G380, German Cancer Research Center, 69120, Heidelberg, Germany
    Acta Neuropathol 116:597-602. 2008
    ..The very high frequency of IDH1 mutations in WHO grade II astrocytic and oligodendroglial gliomas suggests a role in early tumor development...
  62. ncbi Current concepts and management of glioblastoma
    Matthias Preusser
    Department of Medicine I Oncology, Comprehensive Cancer Center Central Nervous System Tumors Unit, Medical University of Vienna, Vienna, Austria
    Ann Neurol 70:9-21. 2011
    b>Glioblastoma is the most common malignant primary brain tumor in adults. Its often rapid clinical course, with many medical and psychosocial challenges, requires a multidisciplinary management...
  63. pmc Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma
    Yu Long Hu
    University of California at San Francisco Neurosurgery, San Francisco, California 94158, USA
    Cancer Res 72:1773-83. 2012
    ..When treated with bevacizumab alone, human glioblastoma xenografts showed increased BNIP3 expression and hypoxia-associated growth, which could be prevented by ..
  64. ncbi A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival
    M Lacroix
    Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
    J Neurosurg 95:190-8. 2001
    OBJECT: The extent of tumor resection that should be undertaken in patients with glioblastoma multiforme (GBM) remains controversial...
  65. pmc miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis
    Michiel Smits
    Neuro oncology Research Group, Departments of Neurosurgery and Pediatric Oncology Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Oncotarget 1:710-20. 2010
    b>Glioblastoma (GBM) is a malignant brain tumor with dismal prognosis. GBM patients have a median survival of less than 2 years. GBM is characterized by fast cell proliferation, infiltrative migration, and by the induction of angiogenesis...
  66. pmc A multigene predictor of outcome in glioblastoma
    Howard Colman
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77401, USA
    Neuro Oncol 12:49-57. 2010
    Only a subset of patients with newly diagnosed glioblastoma (GBM) exhibit a response to standard therapy...
  67. ncbi A hierarchy of self-renewing tumor-initiating cell types in glioblastoma
    Ruihuan Chen
    Department of Tumor Biology and Angiogenesis, Genentech Inc, San Francisco, CA 94080, USA
    Cancer Cell 17:362-75. 2010
    The neural stem cell marker CD133 is reported to identify cells within glioblastoma (GBM) that can initiate neurosphere growth and tumor formation; however, instances of CD133(-) cells exhibiting similar properties have also been reported...
  68. pmc Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
    Teri N Kreisl
    Neuro Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 8200, USA
    J Clin Oncol 27:740-5. 2009
    To evaluate single-agent activity of bevacizumab in patients with recurrent glioblastoma.
  69. ncbi EZH2 is essential for glioblastoma cancer stem cell maintenance
    Mario Luca Suva
    Division of Experimental Pathology, Institute of Pathology, University of Lausanne, Lausanne, Switzerland
    Cancer Res 69:9211-8. 2009
    ..of zeste homologue 2 (EZH2) occurs in diverse malignancies, including prostate cancer, breast cancer, and glioblastoma multiforme (GBM)...
  70. pmc The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype
    John M Heddleston
    Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, OH, USA
    Cell Cycle 8:3274-84. 2009
    ....
  71. ncbi Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network
    Michael Weller
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    J Clin Oncol 27:5743-50. 2009
    The prognostic value of genetic alterations characteristic of glioblastoma in patients treated according to present standards of care is unclear.
  72. pmc A developmental taxonomy of glioblastoma defined and maintained by MicroRNAs
    Tae Min Kim
    Center for Biomedical Informatics, Harvard Medical School, Boston, MA, USA
    Cancer Res 71:3387-99. 2011
    mRNA expression profiling has suggested the existence of multiple glioblastoma subclasses, but their number and characteristics vary among studies and the etiology underlying their development is unclear...
  73. pmc Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice
    Mitomu Kioi
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, California 94305 5152, USA
    J Clin Invest 120:694-705. 2010
    Despite the high doses of radiation delivered in the treatment of patients with glioblastoma multiforme (GBM), the tumors invariably recur within the irradiation field, resulting in a low cure rate...
  74. pmc p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
    Hongwu Zheng
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 455:1129-33. 2008
    b>Glioblastoma (GBM) is a highly lethal brain tumour presenting as one of two subtypes with distinct clinical histories and molecular profiles...
  75. pmc Heterogeneity maintenance in glioblastoma: a social network
    Rudy Bonavia
    Department of Pathology, University of California, San Diego, La Jolla, California, USA
    Cancer Res 71:4055-60. 2011
    b>Glioblastoma multiforme (GBM), the most common intracranial tumor in adults, is characterized by extensive heterogeneity at the cellular and molecular levels...
  76. ncbi TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma
    Judit Anido
    Vall d Hebron Institute of Oncology, Barcelona, Spain
    Cancer Cell 18:655-68. 2010
    ..Here, we show that TGF-β inhibitors, currently under clinical development, target the GIC compartment in human glioblastoma (GBM) patients...
  77. pmc Transdifferentiation of glioblastoma cells into vascular endothelial cells
    Yasushi Soda
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:4274-80. 2011
    b>Glioblastoma (GBM) is the most malignant brain tumor and is highly resistant to intensive combination therapies and anti-VEGF therapies...
  78. ncbi Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide
    Monika E Hegi
    Laboratory of Tumor Biology and Genetics of the Neurosurgery Departments of the University Hospitals, Lausanne, Switzerland
    Clin Cancer Res 10:1871-4. 2004
    ..value of the methylation status of the O-6-methylguanine-DNA methyltransferase (MGMT) promoter for outcome in glioblastoma patients treated with the alkylating agent temozolomide...
  79. pmc Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme
    Albert Lai
    David Geffen School of Medicine at UCLA, Reed Neurological Research Center, Los Angeles, CA 90095, USA
    J Clin Oncol 29:142-8. 2011
    ..combined bevacizumab (BV) with radiation therapy (RT) and temozolomide (TMZ) for the treatment of newly diagnosed glioblastoma (GBM). The objectives were to determine the efficacy of this treatment combination and the associated toxicity.
  80. pmc Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma
    John H Sampson
    Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 28:4722-9. 2010
    ..Epidermal growth factor receptor variant III (EGFRvIII) is a constitutively activated and immunogenic mutation not expressed in normal tissues but widely expressed in glioblastoma multiforme (GBM) and other neoplasms.
  81. ncbi Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma
    Roger Stupp
    Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 46, Lausanne, Switzerland
    J Clin Oncol 28:2712-8. 2010
    Invasion and migration are key processes of glioblastoma and are tightly linked to tumor recurrence...
  82. ncbi Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity
    Monika E Hegi
    Laboratory of Tumor Biology and Genetics, Department of Neurosurgery BH 19 110, Centre Hospitalier Universitaire Vaudois and University of Lausanne, CH 1011 Lausanne, Switzerland
    J Clin Oncol 26:4189-99. 2008
    ..Of note, not all patients with glioblastoma having MGMT promoter methylation respond to alkylating agents, and even those who respond will inevitably ..
  83. ncbi Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma
    Anastasia Murat
    Laboratory of Tumor Biology and Genetics, Centre Universitaire Romand de Neurochirurgie, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne 1011, Switzerland
    J Clin Oncol 26:3015-24. 2008
    ..Here, we aimed to identify molecular profiles specific for treatment resistance to the current standard of care of concomitant chemoradiotherapy with the alkylating agent temozolomide...
  84. ncbi miR-221/222 overexpession in human glioblastoma increases invasiveness by targeting the protein phosphate PTPμ
    C Quintavalle
    Department of Cellular and Molecular Biology and Pathology, Federico II University of Naples, Naples, Italy
    Oncogene 31:858-68. 2012
    b>Glioblastoma is the most frequent brain tumor in adults and is the most lethal form of human cancer. Despite the improvements in treatments, survival of patients remains poor...
  85. pmc Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma
    Baisakhi Raychaudhuri
    Brain Tumor and Neuro Oncology Center, Neurological Institute, Cleveland, OH, USA
    Neuro Oncol 13:591-9. 2011
    ..Patients with glioblastoma have increased MDSC counts (CD33+HLADR-) in their blood that are composed of neutrophilic (CD15(+); >60%), ..
  86. ncbi CD133+ glioblastoma stem-like cells are radiosensitive with a defective DNA damage response compared with established cell lines
    Amy M McCord
    Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida 33612, USA
    Clin Cancer Res 15:5145-53. 2009
    CD133+ glioblastoma tumor stem-like cells (TSC) have been defined as radioresistant...
  87. ncbi SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity
    Rosaria Maria Rita Gangemi
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Stem Cells 27:40-8. 2009
    b>Glioblastoma, the most aggressive cerebral tumor, is invariably lethal. Glioblastoma cells express several genes typical of normal neural stem cells...
  88. pmc Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma
    Tracy T Batchelor
    Stephen E and Catherine Pappas Center for Neuro Oncology, Yawkey 9E, Massachusetts General Hospital Cancer Center, 55 Fruit St, Boston, MA 02114, USA
    J Clin Oncol 28:2817-23. 2010
    b>Glioblastoma is an incurable solid tumor characterized by increased expression of vascular endothelial growth factor (VEGF). We performed a phase II study of cediranib in patients with recurrent glioblastoma.
  89. pmc The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis
    Xuefeng Fang
    Swedish Neuroscience Institute, Swedish Medical Center, Seattle, WA 98122, USA
    BMC Genomics 12:11. 2011
    ..SOX2 appears to re-activate in several human cancers including glioblastoma multiforme (GBM), however, the detailed response program of SOX2 in GBM has not yet been defined.
  90. pmc EGFRvIII antibody-conjugated iron oxide nanoparticles for magnetic resonance imaging-guided convection-enhanced delivery and targeted therapy of glioblastoma
    Costas G Hadjipanayis
    Brain Tumor Nanotechnology Laboratory, Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 70:6303-12. 2010
    ..selectively binds to the epidermal growth factor receptor (EGFR) deletion mutant (EGFRvIII) present on human glioblastoma multiforme (GBM) cells were used for therapeutic targeting and MRI contrast enhancement of experimental ..
  91. ncbi GFAP promoter driven transgenic expression of PDGFB in the mouse brain leads to glioblastoma in a Trp53 null background
    Sanna Maria Hede
    Department of Oncology Pathology, Karolinska Institutet, Karolinska University Hospital Solna, SE 17176, Stockholm, Sweden
    Glia 57:1143-53. 2009
    ..This occurred at 2-6 months of age and tumors displayed human glioblastoma-like features with integrated development of Pdgfralpha+ tumor cells and Pdgfrbeta+/Nestin+ vasculature...
  92. ncbi Isolation of cancer stem cells from adult glioblastoma multiforme
    Xiangpeng Yuan
    Maxine Dunitz Neurosurgical Institute, Suite 800 East, 8631 West 3rd Street, Los Angeles, CA 90048, USA
    Oncogene 23:9392-400. 2004
    b>Glioblastoma multiforme (GBM) is the most common adult primary brain tumor and is comprised of a heterogeneous population of cells. It is unclear which cells within the tumor mass are responsible for tumor initiation and maintenance...
  93. ncbi Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme
    Roberto Pallini
    Department of Neurosurgery, Catholic University of Rome, Rome, Italy
    Clin Cancer Res 14:8205-12. 2008
    ..The stem cell antigen CD133 identifies such a tumorigenic population in a subset of glioblastoma patients...
  94. ncbi SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma
    Myung Jin Son
    Neuro Oncology Branch, National Cancer Institute, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA
    Cell Stem Cell 4:440-52. 2009
    CD133+ populations of human glioblastoma multiforme (GBM) cells are reportedly enriched for tumor stem cells (TSCs) or tumor-initiating cells (TICs)...
  95. ncbi STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells
    Maureen M Sherry
    Department of Physiology, Tufts University, Boston, Massachusetts 02111, USA
    Stem Cells 27:2383-92. 2009
    ..Recently, putative glioblastoma stem cells (GBM-SCs) were isolated and characterized...
  96. ncbi Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
    E C Holland
    Department of Neurosurgery, MD Anderson Cancer Center, Houston, Texas, USA
    Nat Genet 25:55-7. 2000
    ..into four clinical grades, with the most aggressive tumours being grade 4 astrocytomas (also known as glioblastoma multiforme; GBM)...
  97. ncbi The correlation and prognostic significance of MGMT promoter methylation and MGMT protein in glioblastomas
    Van Thang Cao
    Brain Tumor Research Laboratory and Research Institute of Medical Sciences, Chonnam National University, Hwasun Hospital and Medical School, Gwangju, Republic of Korea
    Neurosurgery 65:866-75; discussion 875. 2009
    The aim of this study was to evaluate the correlation and prognostic significance of MGMT promoter methylation and protein expression in patients with glioblastoma.
  98. ncbi Chemotherapy for glioblastoma: current treatment and future perspectives for cytotoxic and targeted agents
    G Minniti
    Sant Andrea Hospital, Department of Radiotherapy Oncology, Via di Grottarossa 1035, 00189 Roma, Italy
    Anticancer Res 29:5171-84. 2009
    b>Glioblastoma is the most frequent and devastating primary malignant brain tumor in adults...
  99. pmc Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice
    John F de Groot
    Brain Tumor Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neuro Oncol 12:233-42. 2010
    ..This model mimicked many of the histopathologic findings from the human cases and will augment the discovery of alternative or additive therapies to prevent this type of tumor recurrence in clinical practice...
  100. ncbi A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2 alpha
    Sascha Seidel
    Institute of Neuropathology, Justus Liebig University, Arndtsr 16, Giessen, Germany
    Brain 133:983-95. 2010
    ..The identification of molecular regulators of tumour stem cells in the hypoxic niche points to specific signalling mechanisms that may be used to target the glioblastoma stem cell population.

Research Grants78

  1. Suppression of glioma invasion by a bicistronic constuct
    JASTI RAO; Fiscal Year: 2007
    Despite many therapeutic strategies for glioblastoma multiforme, the survival rate in patients with this aggressive cerebral malignancy remains poor...
  2. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  3. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..clinically indistinguishable yet biochemically distinct disease pathways underlying the deadly brain cancer glioblastoma multiforme...
  4. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..Aim 1. To determine the biology of OPN-R and OPN-L in human glioblastoma (GBM). We demonstrated significantly elevated levels of OPN-R and OPN-L in CSF samples of patients with GBM...
  5. Overcoming Temozolomide Resistance using MGMT-targeting Spherical Nucleic Acids
    TIMOTHY L SITA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glioblastoma multiforme (GBM) is the most prevalent primary central nervous system malignancy...
  6. High throughput screen for selective inhibitors of cyclophilin B
    Richard J Bram; Fiscal Year: 2013
    ..We recently discovered that it plays an essential role in supporting the proliferation and survival of glioblastoma multiforme (GBM), an important type of brain tumor, as well as several other types of malignancies...
  7. Engineering the Brain Immune System for Tumor Therapy
    Maria G Castro; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Engineering the Brain Immune System for Tumor Therapy Abstract Brain glioblastoma multiforme (GBM) kills through glioma cells that infiltrate normal surrounding brain, with consequent displacement and ..
  8. Studying a novel regulator of GBM tumorigeneis: the role of CK2alpha in maintaini
    Gordon Li; Fiscal Year: 2013
    ..that enhanced expression or activity of the catalytic subunit CK2[unreadable] plays an important role in glioblastoma (GBM) tumorigenesis...
  9. Delivery issues in lung cancer CNS metastases
    Edward A Neuwelt; Fiscal Year: 2013
    ..The dynamic MRI techniques are highly effective in determining response to therapy in glioblastoma;the goal of this proposal is to determine the applicability of these approaches in brain metastases and ..
  10. Autophagy in Brain Tumor
    Jin Ming Yang; Fiscal Year: 2013
    ..is to understand the importance and regulation of autophagy and elongation factor-2 kinase (eEF-2 kinase) in glioblastoma multiforme (GBM), and to develop novel, autophagy targeted strategies for treatment of this most lethal primary ..
  11. Regulation of TGF-beta Signaling and Embryonic Development by GTPases
    Gerald H Thomsen; Fiscal Year: 2010
    ..GTPBP1/2 affect disease is not known, but a chromosomal translocation of GTPBP2 has recently been identified in glioblastoma, a nearly incurable brain cancer...
  12. In vivo imaging of encapsulated stem cells in mouse models of tumor resection
    Khalid A Shah; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The standard treatment for malignant glioblastoma multiforme (GBM) includes maximal surgical tumor resection followed by radiation therapy and adjuvant chemotherapy...
  13. Gutless Adenovirus Mediated Gene Therapy for Glioma
    Maria G Castro; Fiscal Year: 2011
    b>Glioblastoma multiforme (GBM) is the most common subtype of primary brain tumors in adults. GB is very aggressive, highly invasive, and infiltrates critical brain structures...
  14. Slow cycling brain tumor cancer stem cells
    BRENT REYNOLDS; Fiscal Year: 2010
    ..Grade III anaplastic astrocytoma, with a mean patient survival of 3 years. Grade IV glioblastoma multiforme (GBM), the most malignant and common glioma, with a mean survival time of less than 1 year despite ..
  15. Signaling of Integrin Alpha 7
    Jianhua Luo; Fiscal Year: 2009
    ..We found mutations of ITGA7 in prostate cancer, hepatocellular carcinoma, leiomyosarcoma and glioblastoma multiforme with frequencies ranging from 25% to 83%...
  16. The effects of dexamethasone on tumor and microglial cells in glioma
    TERREIA SUTTON JONES; Fiscal Year: 2013
    ..Research: Malignant gliomas account for the vast majority of primary brain tumors, with glioblastoma (GBM) being the most frequent, malignant and deadly overall...
  17. Vaccine Immunotoxin and Radioimmunotherapy of Primary and Metastatic CNS Tumors
    Darell D Bigner; Fiscal Year: 2013
    ..two of the conditions in neuro-oncology which are most refractory to treatment, neoplastic meningitis (NM) and glioblastoma multiforme (GBM)...
  18. Analysis of alphaVbeta8 Integrin In Gliomagenesis
    Joseph H McCarty; Fiscal Year: 2012
    ..we will determine how av[unreadable]8 integrin contributes to the pathogenesis of the deadly brain cancer, glioblastoma multiforme (GBM)...
  19. Signaling of Integrin Alpha 7
    Jianhua Luo; Fiscal Year: 2013
    ..We found mutations on ITGA7 in prostate cancer, hepatocellular carcinoma, leiomyosarcoma and glioblastoma multiforms with frequencies ranging from 25% to 83%...
  20. Effects of Extravasated Serum Proteins on Human Glioblastoma Invasion
    HUNTER REEVE UNDERHILL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glioblastoma multiforme (GBM) is the most common and the most lethal primary brain tumor. Despite advances in a variety of therapies, survival has remained largely unchanged for more than 30 years...
  21. Brain tumors with regulatory T-cells treated with EGFRvIII-specific T-cells
    John H Sampson; Fiscal Year: 2013
    ..b>Glioblastoma (GBM) is uniformly lethal, and current therapy is non-specific and produces a median overall survival of <15 ..
  22. Oncogene cooperation in glioma genesis
    Wei Zhang; Fiscal Year: 2013
    ..The most advanced form of glioma, and also the most invasive and refractory to therapy, is glioblastoma (GBM), which comprises 50-60% of all gliomas. The median survival for GBM patients is less than a year...
  23. Allergic Condition Susceptibility Polymorphisms and Glioma Risk
    Judith Schwartzbaum; Fiscal Year: 2012
    The most common type of adult glioma (a primary malignant brain tumor), glioblastoma, has a five-year survival probability of only 3%...
  24. Cath B and uPAR si RNA constructs regressed glioma growth
    JOHN P O'BRYAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite the many therapeutic strategies undertaken for treatment of glioblastoma multiforme, the survival rate remains low for patients afflicted with this aggressive cerebral malignancy...
  25. The role of a histone H4 phosphorylation in drug resistance
    Zhiguo Zhang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glioblastoma multiforme (GBM) is the most aggressive form of primary brain tumor in humans. Temozolomide (TMZ) is a critical component of therapy for newly-diagnosed GBM...
  26. Gene Targeted Therapy of Brain Tumors
    John H Sampson; Fiscal Year: 2010
    Primary malignant brain tumors, like glioblastoma (GBM), remain universally fatal...
  27. Rho- and GPCR-mediated signaling through novel cellular effectors
    Joan Heller Brown; Fiscal Year: 2012
    ..pathophysiological conditions and utilizes both in vitro and in vivo studies, on mouse astrocytes and a human glioblastoma cell line to discover regulatory mechanisms that could be targeted to block these pathways...
  28. EGFRvIII in Pancreatic Cancer
    Maneesh Jain; Fiscal Year: 2010
    ..most is the most common naturally occurring mutant form of EGFR and is expressed in many cancer types including glioblastoma, breast, ovarian, head and neck, lung and prostate cancer...
  29. Multifunctional nanoparticles to improve treatment of human glioblastoma
    Miqin Zhang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Multifunctional nanoparticles to improve treatment of human glioblastoma The long-term objective of this research is to develop novel therapeutic approaches to improve the clinical outcome of adult ..
  30. Measles Virotherapy and radiovirotherapy in the Treatment of recurrent gliomas
    Evanthia Galanis; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, accounting for most of 18,500 primary brain tumor cases each year in the US...
  31. Modulation of Glioma Growth and Invasion by HCMV Glycoprotein B
    Liliana Soroceanu; Fiscal Year: 2010
    b>Glioblastoma (GBM) is the most common primary brain tumor in adults and is uniformly fatal...
  32. Gene Expression Patterns in Human Tumors Identified Using Transcript Sequencing
    Charles M Perou; Fiscal Year: 2013
    ..Our collaborative efforts identified new tumor subtypes of glioblastoma and painted an integrated picture linking mutations to copy number changes to expression patterns, which ..
  33. Polyvalent siRNA-Gold Nanoparticle Constructs to Eradicate Glioma
    Emily S Day; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Brain tumors are one of the most challenging forms of cancer to treat. Glioblastoma is the most aggressive type of brain tumor and despite medical intervention the median survival is only 12-15 months...
  34. NOVEL THERAPEUTICS FOR PRION DISEASES
    Stanley B Prusiner; Fiscal Year: 2013
    ..At the same time, we propose to use uninfected, human (Hu) glioblastoma cells in our HTS search for compounds that decrease HuPrPc levels...
  35. A phase Ib/II study of AZD2171 and radiation for new brain metastases from NSCLC
    APRIL FITZSIMMONS EICHLER; Fiscal Year: 2010
    ..has recently demonstrated the feasibility and utility of these correlative imaging techniques in patients with glioblastoma, and we are uniquely situated to extend these techniques to the study of AZD2171 in brain metastases...
  36. Genone-wide Discovery of Molecular Alterations in Head and Neck Cancer
    Victor E Velculescu; Fiscal Year: 2010
    ..we have recently refined and used to identify novel tumor-relevant mutations in breast, colon, pancreatic, and glioblastoma tumors...
  37. Molecular mechanisms of GBM radioresistance and strategies for radiosensitization
    Sandeep Burma; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glioblastoma Multiforme (GBM) tumors are the third leading cause of cancer-related death among adults aged 30 - 50 years, even though they account for less than 1...
  38. Genotype and Metabolic Phenotype in Glioblastoma
    Elizabeth A Maher; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Glioblastoma, the most common primary brain tumor in adults, is considered to be among the deadliest of human cancers. With a median survival time of 14...
  39. Comprehensive Phenotypic Comparison of Normal and Cancer Stem Cells
    RAMESH A contact SHIVDASANI; Fiscal Year: 2010
    ..normal and cancer stem cells isolated from normal intestine/colorectal adenocarcinoma, neural stem cells/glioblastoma multiforme (GBM) and hematopoietic stem cells/acute myelogenous leukemia (AML)...
  40. Effect of Bone Marrow Cells on the Radiosensitivity of Brain and Mouth Cancers
    JOHN MARTIN BROWN; Fiscal Year: 2012
    Our overall goal is to improve the cure rates of glioblastoma multiforme (GBM) and of head and neck tumors: human cancers for which the current treatment is radiotherapy (with or without surgery and chemotherapy) and for which treatment ..
  41. Immune effector-mediated killing of CNS tumors in the GL261 model of glioblastoma
    DANIELLE RENNER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glioblastoma multiforme (GBM) is among the most lethal of cancers, with average survival being only 12-15 months after diagnosis...
  42. Defining the role of mutant IDH in glioma initiation and maintenance
    Sheri L Holmen; Fiscal Year: 2013
    ..Recently, high-throughput sequencing of grade IV glioblastoma multiforme (GBM) tumors identified a novel mutation in isocitrate dehydrogenase 1 (IDH1) in 12% of the samples ..
  43. Extracellular Sulfatases As Novel Biomarkers For Early Detection of Cancer
    Joanna Phillips; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Among all cancers, non-small cell lung cancer (NSCLC) and glioblastoma (the most common and most malignant type of astrocytic brain cancer) are two of the most deadly cancers with survival measured in ..
  44. Understanding and Eliminating Oncogenic EGFR Signaling in Malignant Glioma
    Alain Charest; Fiscal Year: 2013
    ..that overexpression of the epidermal growth factor receptor (EGFR) is a major component of the etiology of glioblastoma multiforme (GBM), yet little is known regarding the signaling events that emanate from activated EGFR in GBM...
  45. The Role of HEF1 in Ovarian Cancer Development, Progression, and Metastasis
    Denise C Connolly; Fiscal Year: 2013
    ..Increased expression of HEF1 has been shown to induce invasion in glioblastoma and promote melanoma and lung carcinoma metastasis in humans and mice...
  46. NEXT GENERATION SEQUENCING ADD-ON-PHARMACOGENOMICS RESEARCH NETWROK (PGRN)
    Elaine R Mardis; Fiscal Year: 2013
    ..in an expansion of our understanding of mutations occurring in lung adenocarcinoma, acute myeloid leukemia, and glioblastoma multiforme...
  47. Development of Novel Inducers of Non-Apoptotic Cell Death to Target Glioblastoma
    William A Maltese; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glioblastoma (GBM) is the most common primary brain tumor in adults. Standard treatment involves surgery, followed by radiation and DNA alkylating agents like temozolomide...
  48. Brain Tumor-Penetrating Nanoparticle Delivery with MR-Guided Focused Ultrasound
    Richard J Price; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glioblastoma multiforme (GBM), the most common primary brain cancer, has a 5-year survival rate of <12%...
  49. Evaluation of In Vitro Companion Diagnostic Monoclonal Antibodies for Use in a St
    Christopher Horvath; Fiscal Year: 2013
    ..progesterone and Her2 receptor-negative) breast cancer (BCa), pancreatic adenocarcinoma (PCa) and glioblastoma multiforme (GBM) primary tumors and respective cell lines (MDA- MB-468, Panc-1, U87)...
  50. Cyclophilin B as a therapeutic target in glioblastoma
    Richard J Bram; Fiscal Year: 2013
    ..Together, these studies will test the feasibility of CypB as a novel target for therapy of GBM, and set the stage for transition to clinical studies in humans. ..
  51. Targeted Delivery of a Novel Synthetic Curcumin Analog, EF24 to Glioblastoma and
    MAMORU NONE SHOJI; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Glioblastoma (GBM) is the most common primary brain tumor and the most malignant form of astrocytoma (WHO grade IV)...
  52. Gene-engineered adoptive T cell immunotherapy of GBM
    Laura A Johnson; Fiscal Year: 2012
    ..Current therapy for glioblastoma (GBM), the most common and most malignant of these tumors consists of surgical resection followed by radiation ..
  53. Role of Olig Genes in Human Gliomagenesis
    Santosh Kesari; Fiscal Year: 2011
    ..deficient mouse neural stem cells by expression analysis, and 4) that OLIG2 binds to P21 promoter in human glioblastoma by chromatin immunoprecipitation thus linking OLIG2 to the cell cycle regulatory apparatus...
  54. A Novel Brachytherapy Agent for GBM
    FRANK CALZONE; Fiscal Year: 2013
    ..Despite advances in surgery, chemotherapy, and radiation therapy, the average life span of a patient with glioblastoma multiforme (GBM) is about 15-months from time of diagnosis...
  55. Elimination of Carcinogen-Induced Tumor Stem Cells by ATF5 Loss of Function.
    JAMES ANGELASTRO; Fiscal Year: 2009
    ..High expression of ATF5 occurs in glioblastoma tumors...
  56. Novel approaches to enhance tumor cell cytotoxicity of alkylating agents
    Robert W Sobol; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glioblastoma is a major cause of cancer related death in the United States, with approximately 17,000 new cases of brain cancer diagnosed annually...
  57. In vivo detection of involvement of endogenous BM progenitor cells in glioma
    Ali Syed Arbab; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Because of hypervascular nature of glioblastoma (GBM) and associated active angiogenesis, investigators have added anti-angiogenic treatment as an adjuvant to normalize blood vessels and control ..
  58. Glioma Associated Macrophages Facilitate Local Immunosuppression
    Orin Bloch; Fiscal Year: 2010
    ..tumors are uniformly fatal, and the 5-year survival rate for the highest grade of malignant glial neoplasm, glioblastoma multiforme (GBM), is less than 2%...
  59. Interplay between intrinsic and extrinsic force and glioma aggression
    Matt Barnes; Fiscal Year: 2013
    ..b>Glioblastoma multiforme (GBM), the most common form of glioma, is associated with dismal clinical prognosis...
  60. Receptor Crosstalk in HNSCC Metastatic Progression
    STEVEN ALAN ROSENZWEIG; Fiscal Year: 2013
    ..down-regulated 9/NEDD9) has been identified as a signature protein required for metastasis in melanoma and glioblastoma. Consistent with this, we have shown that VEGF stimulated migration, invasion and invadopodia formation are all ..
  61. A Translational Framework for Methodological Rigor to Improve Patient Centered Ou
    Francesca Dominici; Fiscal Year: 2013
    ..on addressing key challenges on how to best deliver care for a well defined population: elderly diagnosed with Glioblastoma. These will be the largest populations studied to date (N=24,142, Part A Medicare data, N=9,343 SEER-Medicare, ..
  62. EGFRvIII-targeted Bispecific T cell Engagers for brain tumors
    John H Sampson; Fiscal Year: 2013
    ..b>Glioblastoma (GBM), the most common of these tumors, is uniformly lethal...
  63. Multiphoton Fluorescence Lifetime Imaging of Solid Tumors Invivo
    V Krishnan Ramanujan; Fiscal Year: 2010
    ..a portable, clinical FLIM-imaging modality;Implement an intra-operative system for real-time assessment of Glioblastoma multiforme...
  64. MOLECULAR AND FUNCTIONAL ANALYSIS OF HUMAN FGF 1
    Ing Ming Chiu; Fiscal Year: 2000
    ..The investigator has shown that FGF-1 is expressed in gliomas, with a higher level in the more malignant glioblastoma multiform than in anaplastic astrocytoma...
  65. Discovery of exon, microRNA and clinical prognostic markers of glioblastoma survi
    SANDRA L RODRIGUEZ ZAS; Fiscal Year: 2010
    Abstract More than 10,000 people per year in the United States are diagnosed with Glioblastoma multiforme, the most common primary brain tumor, and the median survival (irrespective of therapy) is one year...
  66. INTERSTITIAL NEUTRON THERAPY FOR GLIOBLASTOMA
    ALFRED YOUNG; Fiscal Year: 1991
    Human glioblastoma multiforme (GBM) responds poorly to currently available treatment. Other than surgery, radiation is the only method of treatment that significantly increases survival...
  67. DNA repair-based models of glioblastoma response to radiation and temozolomide
    JOHN SILBER; Fiscal Year: 2009
    ..with the methylating agent temozolomide (TMZ) is now the accepted standard of care for newly diagnosed glioblastoma. Yet response is highly heterogeneous and there is urgent need for markers of treatment outcome...
  68. Brain Tumor Stem Cell-targeted Gene Therapy
    JOHN OHLFEST; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Glioblastoma Multiforme (GBM) is a lethal brain tumor that typically causes death within two years after initial diagnosis. GBM accounts for 25% of all primary brain tumors in adults...
  69. 5-Lipoxygenase inhibition as an adjuvant glioma therapy
    Glen Stevens; Fiscal Year: 2005
    b>Glioblastoma multiforme (GBM) is the most malignant, incurable brain tumor and most patients die in less than a year...
  70. Phase I / II Trial for Neutron Capture Therapy
    Matthew Palmer; Fiscal Year: 2002
    ..Extensive preclinical work and early clinical experiences have shown NCT to be active against melanoma, and glioblastoma, diseases poorly controlled by conventional radiation...
  71. EGFR activity in T cell-influenced glioma invasiveness & chemosensitivity
    Christopher Wheeler; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Glioblastoma multiforme (GBM) is a uniformly fatal primary brain tumor (glioma) for which there is no effective treatment...
  72. Role of ATM in Radiosensitivity of Gliomas
    Chandan Guha; Fiscal Year: 2004
    b>Glioblastoma multiforme (GBM) is one of the most lethal cancers. Radiotherapy prolongs survival only modestly, because the dose is limited by the tolerance of the normal brain tissues...
  73. METVAN: A Novel Anticancer Agent
    OSMOND D CRUZ; Fiscal Year: 2003
    ..apoptosis in human leukemia cells, multiple myeloma cells, and solid tumor cells derived from breast cancer, glioblastoma, ovarian, prostate, and testicular cancer patients...
  74. Measles Virotherapy for Glioblastoma Multiforme
    Evanthia Galanis; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Glioblastoma multiforme is the most common primary brain tumor in adults, accounting for the majority of 18,500 cases of primary brain tumors diagnosed each year in the U.S...
  75. Intravascular Thrombosis in Glioblastoma
    Daniel Brat; Fiscal Year: 2005
    b>Glioblastoma (GBM) is the most common primary brain tumor and also the highest grade (WHO grade IV). Progression to a GBM represents an abrupt turning point, with rapid progression to death following the transition (mean, 50 weeks)...
  76. BASEMENT MEMBRANE GLYCOPROTEIN LAMININ
    Eva Engvall; Fiscal Year: 1991
    Laminin promotes neurite outgrowth from cultured neuronal cells and promotes the adhesion and motility of glioblastoma cells in vitro. Laminin-containing a cellular fetal membranes also show activity in nerve regeneration in vivo...
  77. Growth inhibition of brain tumors by cord blood stem cells
    Jasti S Rao; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Despite the many therapeutic strategies undertaken for treatment of glioblastoma multiforme, the survival rate for patients afflicted with this aggressive cerebral malignancy remains low...
  78. Development of an Adenoviral Vector with Chimeric Fiber for Malignant Glioma
    MACIEJ LESNIAK; Fiscal Year: 2009
    b>Glioblastoma multiforme (GBM) is the most common primary malignant tumor of the adult central nervous system (CNS)...