astrocytoma

Summary

Summary: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)

Top Publications

  1. ncbi Expression of Ki-67, topoisomerase IIalpha and c-MYC in astrocytic tumors: correlation with the histopathological grade and proliferative status
    Mário H G Faria
    Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil
    Neuropathology 26:519-27. 2006
  2. ncbi Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas
    Hiroko Ohgaki
    Pathology Group, International Agency for Research on Cancer HO, F 69372, Lyon, France
    J Neuropathol Exp Neurol 64:479-89. 2005
  3. ncbi Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial
    Wolfgang Wick
    Department of Neuro Oncology, National Centre for Tumour Diseases, University of Heidelberg, Heidelberg, Germany
    Lancet Oncol 13:707-15. 2012
  4. ncbi The use of hsa-miR-21, hsa-miR-181b and hsa-miR-106a as prognostic indicators of astrocytoma
    Feng Zhi
    Research Institute of Modern Medicine, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    Eur J Cancer 46:1640-9. 2010
  5. ncbi Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma
    Genevieve Schindler
    Department of Neurosurgery, Medical Faculty of the Ruprecht Karls University Heidelberg, Mannheim, Germany
    Acta Neuropathol 121:397-405. 2011
  6. pmc Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
    Yuan Zhu
    Center for Developmental Biology and Kent Waldrep Foundation Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cancer Cell 8:119-30. 2005
  7. ncbi Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation
    Caterina Cenci
    RNA editing Laboratory, Ospedale Pediatrico Bambino Gesu Research Institute, Piazza S Onofrio 4, 00165 Rome, Italy
    J Biol Chem 283:7251-60. 2008
  8. pmc ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis
    F Galeano
    Laboratorio di RNA Editing, Oncohaematology Department, Ospedale Pediatrico Bambino Gesu, IRCCS, Rome, Italy
    Oncogene 32:998-1009. 2013
  9. ncbi Inhibition of Rho-kinase affects astrocytoma morphology, motility, and invasion through activation of Rac1
    Bodour Salhia
    The Arthur and Sonia Labatt Brain Tumour Research Center and Division of Neurosurgery, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada
    Cancer Res 65:8792-800. 2005
  10. pmc Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
    David T W Jones
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Nat Genet 45:927-32. 2013

Detail Information

Publications378 found, 100 shown here

  1. ncbi Expression of Ki-67, topoisomerase IIalpha and c-MYC in astrocytic tumors: correlation with the histopathological grade and proliferative status
    Mário H G Faria
    Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil
    Neuropathology 26:519-27. 2006
    ..Ki-67 antigen detection in more than 8.0% of the tumor cells distinguished astrocytoma grade IV, while a labeling index between 1.5 and 8.0% characterized astrocytomas grade III and values below 1...
  2. ncbi Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas
    Hiroko Ohgaki
    Pathology Group, International Agency for Research on Cancer HO, F 69372, Lyon, France
    J Neuropathol Exp Neurol 64:479-89. 2005
    ..6 years for low-grade astrocytoma WHO grade II, 1.6 years for anaplastic astrocytoma grade III, and 0.4 years for glioblastoma...
  3. ncbi Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial
    Wolfgang Wick
    Department of Neuro Oncology, National Centre for Tumour Diseases, University of Heidelberg, Heidelberg, Germany
    Lancet Oncol 13:707-15. 2012
    Radiotherapy is the standard care in elderly patients with malignant astrocytoma and the role of primary chemotherapy is poorly defined...
  4. ncbi The use of hsa-miR-21, hsa-miR-181b and hsa-miR-106a as prognostic indicators of astrocytoma
    Feng Zhi
    Research Institute of Modern Medicine, Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China
    Eur J Cancer 46:1640-9. 2010
    ..In the present study, the miRNA expression profile was examined in astrocytoma, a malignant and prevalent intracranial tumour in adults.
  5. ncbi Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma
    Genevieve Schindler
    Department of Neurosurgery, Medical Faculty of the Ruprecht Karls University Heidelberg, Mannheim, Germany
    Acta Neuropathol 121:397-405. 2011
    ..Future clinical trials should address whether BRAF (V600E) mutant brain tumor patients will benefit from BRAF (V600E)-directed targeted therapies...
  6. pmc Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
    Yuan Zhu
    Center for Developmental Biology and Kent Waldrep Foundation Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cancer Cell 8:119-30. 2005
    Malignant astrocytoma, the most prevalent primary brain tumor, is resistant to all known therapies and frequently harbors mutations that inactivate p53 and activate Ras signaling...
  7. ncbi Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation
    Caterina Cenci
    RNA editing Laboratory, Ospedale Pediatrico Bambino Gesu Research Institute, Piazza S Onofrio 4, 00165 Rome, Italy
    J Biol Chem 283:7251-60. 2008
    ..We reintroduced either ADAR2 or the inactive version of ADAR2 in three astrocytoma cell lines (U118, A172, U87)...
  8. pmc ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis
    F Galeano
    Laboratorio di RNA Editing, Oncohaematology Department, Ospedale Pediatrico Bambino Gesu, IRCCS, Rome, Italy
    Oncogene 32:998-1009. 2013
    Grade IV astrocytoma or glioblastoma multiforme (GBM) is one of the most aggressive and lethal tumors affecting humans...
  9. ncbi Inhibition of Rho-kinase affects astrocytoma morphology, motility, and invasion through activation of Rac1
    Bodour Salhia
    The Arthur and Sonia Labatt Brain Tumour Research Center and Division of Neurosurgery, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada
    Cancer Res 65:8792-800. 2005
    ..Whereas the molecular and cellular mechanisms governing astrocytoma invasion remain poorly understood, evidence in other cell systems has implicated a role for the Rho-GTPases in ..
  10. pmc Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
    David T W Jones
    Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Nat Genet 45:927-32. 2013
    Pilocytic astrocytoma, the most common childhood brain tumor, is typically associated with mitogen-activated protein kinase (MAPK) pathway alterations...
  11. pmc Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain
    Lionel M L Chow
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 19:305-16. 2011
    ..Gene expression profiling revealed striking similarities to subclasses of human diffuse astrocytoma. Astrocytomas were found within and outside of proliferative niches in the adult brain.
  12. ncbi Genome-wide expression profiling identifies deregulated miRNAs in malignant astrocytoma
    Soumya A M Rao
    Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India
    Mod Pathol 23:1404-17. 2010
    Malignant astrocytoma includes anaplastic astrocytoma (grade III) and glioblastoma (grade IV). Among them, glioblastoma is the most common primary brain tumor with dismal responses to all therapeutic modalities...
  13. pmc Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas
    Joshua D Schiffman
    Divison of Pediatric Hematology Oncology and Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, USA
    Cancer Res 70:512-9. 2010
    ..Taken together, these findings highlight BRAF as a frequent mutation target in pediatric astrocytomas, with distinct types of BRAF alteration occurring in grade 1 versus grade 2 to 4 tumors...
  14. ncbi Does vasculogenic mimicry exist in astrocytoma?
    Wei Ying Yue
    Department of Neurosurgery and Neuro Oncology, Cancer Center, Sun Yat Sen University, Guangzhou, PR China 510060
    J Histochem Cytochem 53:997-1002. 2005
    ..It is unknown whether a similar VM phenomenon exists in astrocytoma. The present study was to examine 45 astrocytomas (including World Health Organization grade II 15 cases, grade ..
  15. pmc Pten haploinsufficiency accelerates formation of high-grade astrocytomas
    Chang Hyuk Kwon
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
    Cancer Res 68:3286-94. 2008
    ..In the present study, we introduced CNS heterozygosity of Pten into the Nf1/p53 astrocytoma model...
  16. ncbi Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma
    Adam M Fontebasso
    1 Division of Experimental Medicine, Montreal Children s Hospital, McGill University and McGill University Health Centre, Montreal, Quebec, Canada 2
    Nat Genet 46:462-6. 2014
    ..This work considerably expands the number of potential treatment targets and further justifies pretreatment biopsy in pediatric mHGA as a means to orient therapeutic efforts in this disease. ..
  17. ncbi Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma
    Y Sonoda
    Brain Tumor Research Center, Department of Neurological Surgery, University of California-San Francisco, San Francisco, California 94115, USA
    Cancer Res 61:6674-8. 2001
    ..converted normal human astrocytes into cells that formed intracranial tumors resembling human anaplastic astrocytoma (AA)...
  18. pmc BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model
    Eric H Raabe
    Division of Pediatric Oncology and Departments of Pathology and Pediatrics and Adolescent Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Clin Cancer Res 17:3590-9. 2011
    BRAF is frequently activated by gene fusion or point mutation in pilocytic astrocytoma, the most common pediatric brain tumor...
  19. ncbi Everolimus: in patients with subependymal giant cell astrocytoma associated with tuberous sclerosis complex
    Monique P Curran
    Adis, a Wolters Kluwer Business, Auckland, New Zealand
    Paediatr Drugs 14:51-60. 2012
    ..0 mg/m(2)) was associated with a significant reduction in the volume of the largest subependymal giant cell astrocytoma (SEGA) in 28 patients aged ≥3 years with tuberous sclerosis complex (TSC) in a phase II trial (C2485)...
  20. ncbi Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model
    Shu Chi Wang
    Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan
    Lab Invest 92:151-62. 2012
    ....
  21. ncbi MGMT activity, promoter methylation and immunohistochemistry of pretreatment and recurrent malignant gliomas: a comparative study on astrocytoma and glioblastoma
    Markus Christmann
    Institute of Toxicology, University Medical Center Mainz, D 55131 Mainz, Germany
    Int J Cancer 127:2106-18. 2010
    ..We also show that promoter methylation assay is superior over immunohistochemistry in determining the MGMT status defined by a given MGMT activity level...
  22. ncbi Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas
    H Ding
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada
    Cancer Res 61:3826-36. 2001
    ..We developed a transgenic mouse astrocytoma model using the glial fibrillary acidic protein (GFAP) promoter to express oncogenic V(12)Ha-ras, specifically ..
  23. pmc Primary ciliogenesis defects are associated with human astrocytoma/glioblastoma cells
    Joanna J Moser
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    BMC Cancer 9:448. 2009
    ..To begin to address this issue, we compared the structure and expression of primary cilia in a normal human astrocyte cell line with five human astrocytoma/glioblastoma cell lines.
  24. ncbi Upregulation of ASCL1 and inhibition of Notch signaling pathway characterize progressive astrocytoma
    Kumaravel Somasundaram
    1Department of Microbiology and Cell Biology, Indian Institute of Science, Malleswaram, Bangalore 560012, India
    Oncogene 24:7073-83. 2005
    b>Astrocytoma is the most common type of brain cancer constituting more than half of all brain tumors...
  25. ncbi Analysis of the IDH1 codon 132 mutation in brain tumors
    Jörg Balss
    Clinical Cooperation Unit Neuropathology G380, German Cancer Research Center, 69120, Heidelberg, Germany
    Acta Neuropathol 116:597-602. 2008
    ..The very high frequency of IDH1 mutations in WHO grade II astrocytic and oligodendroglial gliomas suggests a role in early tumor development...
  26. pmc Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity
    Amy K Keating
    Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
    Mol Cancer Ther 9:1298-307. 2010
    ..shRNA-mediated knockdown of Mer and Axl RTK expression led to an increase in apoptosis in astrocytoma cells...
  27. ncbi The clinical value of Ki-67/MIB-1 labeling index in human astrocytomas
    Anne Linn Johannessen
    Department of Pathology and Medical Genetics, Children s and Women s Health, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
    Pathol Oncol Res 12:143-7. 2006
    ..It may be especially useful in cases where histology reveals a low-grade astrocytoma whereas other parameters indicate a more malignant neoplasm...
  28. pmc MAPK pathway activation in pilocytic astrocytoma
    David T W Jones
    Division of Molecular Genetics, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Cell Mol Life Sci 69:1799-811. 2012
    Pilocytic astrocytoma (PA) is the most common tumor of the pediatric central nervous system (CNS)...
  29. pmc Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma
    Mehdi H Shahi
    Brain Tumor Biology Unit CIFA, University of Navarra School of Sciences, Pamplona, Spain
    BMC Cancer 10:614. 2010
    ..2 and PAX6 in medulloblastoma and astrocytic tumors...
  30. ncbi ECT2 and RASAL2 mediate mesenchymal-amoeboid transition in human astrocytoma cells
    Adrienne Weeks
    Division of Neurosurgery, Department of Surgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 181:662-74. 2012
    ..The Rho family of cytoskeletal GTPases are key regulators of astrocytoma migration and invasion; expression of the guanine nucleotide exchange factor ECT2 is elevated in primary ..
  31. pmc Overexpression of c-erbB2 is a negative prognostic factor in anaplastic astrocytomas
    Sasha Gulati
    Department of Neurosurgery, St Olavs University Hospital, Trondheim, Norway
    Diagn Pathol 5:18. 2010
    ..The synchronous overexpression of c-erbB1-4 proteins in anaplastic astrocytomas supports their role in the pathogenesis of these tumors. Further, c-erbB2 overexpression seems to predict aggressive behaviour...
  32. ncbi A3 adenosine receptors in human astrocytoma cells: agonist-mediated desensitization, internalization, and down-regulation
    M L Trincavelli
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Università Pisa, Pisa, Italy
    Mol Pharmacol 62:1373-84. 2002
    ..investigated desensitization, internalization, and down-regulation of native A(3) adenosine receptors in human astrocytoma cells after exposure to the agonist 2-chloro-N6-(3-iodobenzyl)-N-methyl-5'-carbamoyladenosine (Cl-IBMECA)...
  33. ncbi BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma
    Cynthia Hawkins
    Division of Pathology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Clin Cancer Res 17:4790-8. 2011
    ..However, the clinical significance of this genetic alteration is yet to be determined. We aimed to test the prognostic role of the B-K fusion in progression of incompletely resected PLGA...
  34. pmc Mitochondrial lactate dehydrogenase is involved in oxidative-energy metabolism in human astrocytoma cells (CCF-STTG1)
    Joseph Lemire
    Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada
    PLoS ONE 3:e1550. 2008
    ..Taken together, this study implicates lactate as an important contributor to ATP metabolism in the brain, a finding that may significantly change our notion of how this important organ manipulates its energy budget...
  35. pmc Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects
    Karlyne M Reilly
    Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 101:13008-13. 2004
    b>Astrocytoma is the most common malignant brain tumor in humans. Loss of the p53 signaling pathway and up-regulation of the ras signaling pathway are common during tumor progression...
  36. pmc Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation
    Michaela Livia Bajenaru
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Mol Cell Biol 22:5100-13. 2002
    ..the contribution of the NF1 gene product, neurofibromin, to astrocyte growth regulation and NF1-associated astrocytoma formation, we generated astrocyte-specific Nf1 conditional knockout mice (Nf1(GFAP)CKO) by using Cre/LoxP ..
  37. ncbi PET imaging of brain astrocytoma with 1-11C-acetate
    Ren Shyan Liu
    National PET Cyclotron Center, Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Eur J Nucl Med Mol Imaging 33:420-7. 2006
    ..The purpose of this study was to assess the use of 1-(11)C-acetate (ACE) as a metabolic tracer for the detection and characterisation of astrocytomas...
  38. ncbi Interferon-gamma-dependent cytotoxic activation of human astrocytes and astrocytoma cells
    Sadayuki Hashioka
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1W5 Canada
    Neurobiol Aging 30:1924-35. 2009
    ..These findings suggest that activated astrocytes may become neurotoxic when stimulated by IFN-gamma and may therefore exacerbate the pathology in a spectrum of neurodegenerative diseases...
  39. ncbi The definition of primary and secondary glioblastoma
    Hiroko Ohgaki
    Molecular Pathology Section, International Agency for Research on Cancer, Lyon, France
    Clin Cancer Res 19:764-72. 2013
    ..Secondary glioblastomas progress from low-grade diffuse astrocytoma or anaplastic astrocytoma...
  40. ncbi The small alpha5beta1 integrin antagonist, SJ749, reduces proliferation and clonogenicity of human astrocytoma cells
    Anne Maglott
    Département de Pharmacologie et Physicochimie, Universite Louis Pasteur Strasbourg, Illkirch, France
    Cancer Res 66:6002-7. 2006
    ..We investigated the effects of SJ749 in two human astrocytoma cell lines, A172 and U87, which express different levels of alpha5beta1...
  41. ncbi The impact of age and sex on the incidence of glial tumors in New York state from 1976 to 1995
    B P McKinley
    Department of Educational Affairs and Neurosurgery, Roswell Park Cancer Institute, State University of New York at Buffalo, 14263, USA
    J Neurosurg 93:932-9. 2000
    ..the authors describe secular trends in the incidence of three glial tumors--glioblastoma multiforme (GBM), astrocytoma not otherwise specified (ANOS), and anaplastic astrocytoma (AA)--in New York state from 1976 through 1995...
  42. ncbi [The new WHO classification of tumors of the nervous system 2000. Pathology and genetics]
    H Radner
    Institut für Neuropathologie, Universitatsklinikum Bonn, Hirntumor Referenzzentrum, Deutschen Gesellschaft für Neuropathologie und Neuroanatomie e V
    Pathologe 23:260-83. 2002
    ..With this combination of pathology and genetics it has set the stage for a new format of the WHO tumor classification series...
  43. ncbi Clinical implications and prognostic value of EMMPRIN/CD147 and MMP2 expression in pediatric gliomas
    Jian Gu
    Department of Pediatrics, Taihe Hospital Affiliated with the Yunyang Medical College, Shiyan, Hubei, 442000, China
    Eur J Pediatr 168:705-10. 2009
    ..The intensively positive expression rates of EMMPRIN (22/27) and MMP2 (21/27) in anaplastic astrocytoma and glioblastoma tissues were significantly higher than those in normal brain and low-grade astrocytoma tissues ..
  44. pmc Expression and localization of scatter factor/hepatocyte growth factor in human astrocytomas
    P Kunkel
    Department of Neurosurgery, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Neuro Oncol 3:82-8. 2001
    ..Lack of SF/HGF expression by most cultured glioblastoma cells is not representative of the in vivo situation and most likely represents a culture artifact...
  45. pmc Human U87 astrocytoma cell invasion induced by interaction of βig-h3 with integrin α5β1 involves calpain-2
    Jie Ma
    Department of Neurosurgery, Tangdu Hospital, Forth Military Medical University, Xi an, China
    PLoS ONE 7:e37297. 2012
    ..Our data showed that βig-h3 co-localized with integrin α5β1 to enhance the invasion of U87 cells, and that calpain-2, is involved in this process, acting as a downstream molecule...
  46. pmc RAF gene fusion breakpoints in pediatric brain tumors are characterized by significant enrichment of sequence microhomology
    Andrew R J Lawson
    Queen Mary University of London, Centre for Neuroscience and Trauma, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Genome Res 21:505-14. 2011
    ....
  47. ncbi Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation
    Andrew Xiao
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cancer Cell 1:157-68. 2002
    ..Using a conditional allele of T(121), early lethality was circumvented, and adult mice developed high-grade astrocytoma, in which regions of decreased apoptosis expressed activated Akt...
  48. pmc Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours
    K Jacob
    Department of Pediatrics and Human Genetics, Montreal Children s Hospital, McGill University Health Center, Montreal H3Z 2Z3, Canada
    Br J Cancer 101:722-33. 2009
    ..Our aim was to investigate additional chromosomal unbalances in LGA and whether incidence of 7q34 duplication is associated with tumour type or location...
  49. ncbi Molecular genetic analysis of p53 intratumoral heterogeneity in human astrocytic brain tumors
    Zhi Ping Ren
    Department of Genetics and Pathology, Uppsala University, University Hospital, Uppsala, Sweden
    J Neuropathol Exp Neurol 66:944-54. 2007
    ..of heterozygosity was common, at least in astrocytomas grade III and in glioblastomas, and also occurred in astrocytoma grade II areas...
  50. ncbi Expression of oligodendroglial differentiation markers in pilocytic astrocytomas identifies two clinical subsets and shows a significant correlation with proliferation index and progression free survival
    Hidehiro Takei
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Neurooncol 86:183-90. 2008
    The growth pattern of pilocytic astrocytoma (PAs) is unpredictable. Gene expression profiling has recently demonstrated an inverse relationship between myelin basic protein (MBP) expression and progression free survival (PFS) in PAs...
  51. ncbi Differentiation of recurrent astrocytoma from radiation necrosis: a pilot study with 13N-NH3 PET
    Zhang Xiangsong
    Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat Sen University, 58 Zhongshan Road II, Guangzhou, 510080, China
    J Neurooncol 82:305-11. 2007
    ..The present study assessed the role of (13)N-NH(3) PET in differentiating recurrent cerebral astrocytoma from radiation necrosis.
  52. pmc Neuronal-astrocyte metabolic interactions: understanding the transition into abnormal astrocytoma metabolism
    Dennis A Turner
    Neurosurgery and Neurobiology, Duke University Medical Center, and Research and Surgery Services, Durham VAMC, Durham, NC 27710, USA
    J Neuropathol Exp Neurol 70:167-76. 2011
    ..b>Astrocytoma cells seem to retain basic metabolic mechanisms of astrocytes; for example, they show a high glycolytic rate, ..
  53. ncbi O6-methylguanine-DNA methyltransferase methylation and TP53 mutation in malignant astrocytomas and their relationships with clinical course
    Takao Watanabe
    Department of Neurological Surgery, Nihon University School of Medicine, 30 1 Oyaguchi kamumachi, Itabashi ku, Tokyo 173 8610, Japan
    Int J Cancer 113:581-7. 2005
    ..These findings highlight the importance of MGMT methylation as a specific predictive factor for responsiveness to nitrosourea chemotherapy...
  54. ncbi A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2'-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells
    Stefania Ceruti
    University of Milan and Center of Excellence for Neurodegenerative Diseases CEND Via Balzaretti 9, 20133 Milan, Italy
    Mol Pharmacol 63:1437-47. 2003
    ..agent 2-chloro-2'-deoxy-adenosine (Cladribine) and its derivative 2-chloro-adenosine induce apoptosis of human astrocytoma cells (J Neurosci Res 60:388-400, 2000)...
  55. pmc The microRNA and messengerRNA profile of the RNA-induced silencing complex in human primary astrocyte and astrocytoma cells
    Joanna J Moser
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    PLoS ONE 5:e13445. 2010
    ..To date there are no published reports of the profile of miRNA and mRNA targeted to the RISC or a comparison of the RISC-specific miRNA/mRNA profile differences in malignant and non-malignant cells...
  56. pmc The human immunodeficiency virus type 1 Tat protein up-regulates the promoter activity of the beta-chemokine monocyte chemoattractant protein 1 in the human astrocytoma cell line U-87 MG: role of SP-1, AP-1, and NF-kappaB consensus sites
    S P Lim
    Institute of Molecular and Cell Biology, Singapore 117609, Singapore
    J Virol 74:1632-40. 2000
    ..Transient transfection of an expression construct encoding the full-length Tat into the human glioblastoma-astrocytoma cell line U-87 MG enhances reporter gene activity from cotransfected deletion constructs of the MCP-1 promoter...
  57. ncbi Caspase-dependent generation of reactive oxygen species in human astrocytoma cells contributes to resistance to TRAIL-mediated apoptosis
    K Choi
    Department of Bio and Brain Engineering, KAIST, Daejeon, Korea
    Cell Death Differ 17:833-45. 2010
    ..oxygen species (ROS), that inhibits caspase-dependent cell death induced by TRAIL ligation in human malignant astrocytoma cells...
  58. ncbi Microglia in brain tumors
    Manuel B Graeber
    Department of Neuropathology, Faculty of Medicine, Imperial College, London, United Kingdom
    Glia 40:252-9. 2002
    ..g., interferon-gamma) will benefit patients with brain tumors could prove fatally wrong. Therapeutic recruitment of microglia to treat such diffusely infiltrative brain tumors as astrocytic gliomas must be considered premature...
  59. ncbi Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma
    Huriye Cin
    Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany
    Acta Neuropathol 121:763-74. 2011
    Activation of the MAPK signaling pathway has been shown to be a unifying molecular feature in pilocytic astrocytoma (PA)...
  60. pmc Underediting of glutamate receptor GluR-B mRNA in malignant gliomas
    S Maas
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 98:14687-92. 2001
    ..Our results suggest a role for RNA editing in tumor progression and may provide a molecular model explaining the occurrence of epileptic seizures in association with malignant gliomas...
  61. ncbi PBEF1/NAmPRTase/Visfatin: a potential malignant astrocytoma/glioblastoma serum marker with prognostic value
    P Sreekanth Reddy
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India
    Cancer Biol Ther 7:663-8. 2008
    Malignant astrocytomas comprise anaplastic astrocytoma (AA; grade III) and Glioblastoma (GBM; grade IV). GBM is the most malignant with a median survival of 10-12 months in patients...
  62. pmc Targeting oncogenic miR-335 inhibits growth and invasion of malignant astrocytoma cells
    Minfeng Shu
    Department of Pharmacology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    Mol Cancer 10:59. 2011
    ..Gain of chromosome 7 with a hot spot at 7q32 appears to be the most prominent aberration in astrocytoma. Previously reports have shown that microRNA-335 (miR-335) resided on chromosome 7q32 is deregulated in many ..
  63. ncbi CIC and FUBP1 mutations in oligodendrogliomas, oligoastrocytomas and astrocytomas
    Felix Sahm
    Department of Neuropathology, Ruprecht Karls Universitat Heidelberg, Im Neuenheimer Feld 220 221, 69120 Heidelberg, Germany
    Acta Neuropathol 123:853-60. 2012
    ..CIC and FUBP1 mutations exclusively occurred in presence of either IDH1 or IDH2 mutations. Our data confirm CIC and FUBP1 mutations in oligodendrogliomas and demonstrate the presence of these mutations in oligoastrocytomas...
  64. ncbi The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression
    Nhan L Tran
    Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, Arizona 85004, USA
    J Biol Chem 280:3483-92. 2005
    ..Targeted therapy against Fn14 as an adjuvant to surgery may improve management of invasive glioma cells and advance the outcome of this devastating cancer...
  65. ncbi Activation of Wnt/beta-catenin/Tcf signaling pathway in human astrocytomas
    Gangadhara Reddy Sareddy
    Department of Biotechnology and Animal Sciences, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India
    Neurochem Int 55:307-17. 2009
    ..Our studies tend to suggest that Wnt/beta-catenin/Tcf signaling pathway is implicated in malignancy of astrocytomas...
  66. ncbi Prognostic significance of IL-8-STAT-3 pathway in astrocytomas: correlation with IL-6, VEGF and microvessel morphometry
    Christina Piperi
    Department of Biological Chemistry, Medical School, University of Athens, Athens, Greece
    Cytokine 55:387-95. 2011
    ..The prognostic significance of IL-8 expression and its correlation with p-STAT-3 and VEGF implicates this novel signaling pathway in astroglial tumors progression providing new targets for effective immunotherapy...
  67. ncbi Supratentorial high-grade astrocytoma and diffuse brainstem glioma: two challenges for the pediatric oncologist
    Alberto Broniscer
    Division of Neuro Oncology, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Oncologist 9:197-206. 2004
    ..Because the outcome for patients with either type of tumor is poor when standard multimodality therapy is used, these children are ideal candidates for innovative treatment approaches...
  68. ncbi Transforming growth factor-beta-inducible gene-h3 (beta(ig)-h3) promotes cell adhesion of human astrocytoma cells in vitro: implication of alpha6beta4 integrin
    Mi Ok Kim
    Graduate School of East West Medical Science, Kyung Hee University, 1 Seochun, Yong In 449 701, South Korea
    Neurosci Lett 336:93-6. 2003
    ..When U87 human astrocytoma cells were seeded on dishes coated with recombinant beta(ig)-h3, cell adhesion was significantly enhanced...
  69. ncbi Baseline levels of glucose metabolites, glutamate and glycerol in malignant glioma assessed by stereotactic microdialysis
    Michael Roslin
    Department of Neurosurgery, Umea University Hospital, Umea, Sweden
    J Neurooncol 61:151-60. 2003
    The metabolism of high grade astrocytoma was studied in 15 patients using intra-tumoural microdialysis. Two catheters were implanted during a stereotactic biopsy procedure: one in the tumour and one in the peri-tumoural tissue...
  70. ncbi Classification of human astrocytic gliomas on the basis of gene expression: a correlated group of genes with angiogenic activity emerges as a strong predictor of subtypes
    Sophie Godard
    Laboratory of Tumor Biology and Genetics, University Hospital CHUV, 1011 Lausanne, Switzerland
    Cancer Res 63:6613-25. 2003
    ..By performing cDNA-array analysis of 53 patient biopsies, comprising low-grade astrocytoma, secondary glioblastoma (respective recurrent high-grade tumors), and newly diagnosed primary glioblastoma, we ..
  71. pmc Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene
    Angela J Sievert
    Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Brain Pathol 19:449-58. 2009
    ..Further studies are required to determine the role of this fusion gene in downstream MAPK signaling and its role in development of pediatric low-grade astrocytomas...
  72. ncbi Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation
    Andrew Xiao
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Cancer Res 65:5172-80. 2005
    ..Pten is frequently mutated in aggressive astrocytoma but not in low-grade astrocytoma. However, the Pten astrocytoma suppression mechanisms are unknown...
  73. ncbi Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma
    Y Sonoda
    Brain Tumor Research Center, Department of Neurological Surgery, University of California-San Francisco, San Francisco, California 94115, USA
    Cancer Res 61:4956-60. 2001
    ..These results identify four pathways as key in the development of human anaplastic astrocytomas...
  74. ncbi Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C --> A:T mutations of the TP53 tumor suppressor gene
    M Nakamura
    International Agency for Research on Cancer, F-69372 Lyon, France
    Carcinogenesis 22:1715-9. 2001
    ....
  75. pmc Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain
    Purna Mukherjee
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Mol Cancer 7:37. 2008
    ..Activated AMPK acts as either an inducer or suppressor of apoptosis depending on the severity of energy stress and the presence or absence of certain functional tumor suppressor genes...
  76. ncbi Acidic triterpenes compromise growth and survival of astrocytoma cell lines by regulating reactive oxygen species accumulation
    Ruben Martin
    Instituto de Biologia y Genetica Molecular, Consejo Superior de Investigaciones Cientificas Universidad de Valladolid, C Sanz y Fores s n, 47003 Valladolid, Spain
    Cancer Res 67:3741-51. 2007
    ..examine how the pentacyclic triterpenes, oleanolic acid and maslinic acid, isolated from olive juice, affected astrocytoma cell morphology and survival...
  77. ncbi MiRNA-196 is upregulated in glioblastoma but not in anaplastic astrocytoma and has prognostic significance
    Yanlei Guan
    Department of Neurosurgery and Neuropathology, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 16:4289-97. 2010
    ..They are implicated in tumorigenesis and function both as tumor suppressors and as oncogenes. The clinical significance of miRNA expression profiles in malignant gliomas remains unclear...
  78. pmc IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas
    Takuya Watanabe
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon, France
    Am J Pathol 174:1149-53. 2009
    ..88%) and in secondary glioblastomas that developed through progression from low-grade diffuse or anaplastic astrocytoma (82%)...
  79. ncbi Expression analysis of juvenile pilocytic astrocytomas by oligonucleotide microarray reveals two potential subgroups
    Kwong Kwok Wong
    Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 65:76-84. 2005
    Juvenile pilocytic astrocytoma (JPA) is one of the most common brain tumors in children. The expression profiles of 21 JPAs, determined using Affymetrix GeneChip U133A, were compared with subjects with normal cerebella...
  80. pmc Improved grading and survival prediction of human astrocytic brain tumors by artificial neural network analysis of gene expression microarray data
    Lawrence P Petalidis
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Mol Cancer Ther 7:1013-24. 2008
    ..Finally, 11 gene classifiers that differentiate between primary and secondary glioblastomas were also identified...
  81. ncbi Independent association of extent of resection with survival in patients with malignant brain astrocytoma
    Matthew J McGirt
    Department of Neurosurgery and Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Neurosurg 110:156-62. 2009
    ..In this study, the authors investigate this issue after primary and revision resection of these lesions...
  82. pmc A biobehavioral perspective on depressive symptoms in patients with cerebral astrocytoma
    Angela R Starkweather
    Virginia Commonwealth University School of Nursing, Richmond, VA, USA
    J Neurosci Nurs 43:17-28. 2011
    ..brain tumor in the United States each year, and for those with the most common type of malignant tumor, an astrocytoma, almost 75% will die within 5 years of diagnosis...
  83. pmc Influence of caloric restriction on constitutive expression of NF-κB in an experimental mouse astrocytoma
    Tiernan J Mulrooney
    Tumor Biology Program, Georgetown University Medical Center, Washington, DC, United States of America
    PLoS ONE 6:e18085. 2011
    ..Although we have shown that CR manages tumor growth and improves survival through multiple molecular and biochemical mechanisms, little information is known about the role that CR plays in modulating inflammation in brain tumor tissue...
  84. ncbi TRAIL induces MMP-9 expression via ERK activation in human astrocytoma cells
    Jong Hyun Kim
    Department of Microbiology, Ajou University School of Medicine, Suwon, Republic of Korea
    Biochem Biophys Res Commun 377:195-9. 2008
    ..We demonstrated that TRAIL induces MMP-9 expression in human astrocytoma cells, which is preceded by activation of extracellular signal-regulated protein kinase (ERK)...
  85. ncbi Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration
    J S Yu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Cancer Res 61:842-7. 2001
    ..cells were administered to seven patients with glioblastoma multiforme and two patients with anaplastic astrocytoma. Dendritic cell vaccination elicited systemic cytotoxicity in four of seven tested patients...
  86. ncbi Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells
    Andis Klegeris
    Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada
    FASEB J 20:2000-8. 2006
    ..Here we report that alpha-synuclein strongly stimulates human astrocytes as well as human U-373 MG astrocytoma cells to up-regulate both interleukin (IL)-6 and ICAM-1 (ED50=5 microg ml(-1))...
  87. ncbi Expression patterns of 5-lipoxygenase in human brain with traumatic injury and astrocytoma
    Lei Zhang
    Department of Pharmacology, The Second Affiliated Hospital, Zhejiang University, Hangzhou, China
    Neuropathology 26:99-106. 2006
    ..Furthermore, 5-LOX expression increased and showed a granular pattern in high-grade (grade III/IV) astrocytoma. These results indicate that 5-LOX has multiple expression patterns, and can be induced by brain injury, which ..
  88. ncbi Kinetic studies of the effects of Temodal and quercetin on astrocytoma cells
    Joanna Jakubowicz-Gil
    Department of Comparative Anatomy and Anthropology, Maria Curie Sklodowska University, Akademicka 19, PL 20 033 Lublin, Poland
    Pharmacol Rep 63:403-16. 2011
    ..was to investigate the kinetics of the effects exerted by Temodal and quercetin on the survival of the human astrocytoma MOGGCCM cell line...
  89. ncbi Progesterone receptor and SRC-1 participate in the regulation of VEGF, EGFR and Cyclin D1 expression in human astrocytoma cell lines
    Olivia Tania Hernández-Hernández
    Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de Mexico, Mexico
    J Steroid Biochem Mol Biol 132:127-34. 2012
    ..The regulation of VEGF, EGFR and cyclin D1 expression by P in human astrocytoma cells is not known...
  90. pmc Gamma-aminobutyric acid inhibits synergistic interleukin-6 release but not transcriptional activation in astrocytoma cells
    Joseph D Roach
    Department of Chemistry, University of Nevada, Las Vegas, Nevada 89154 4003, USA
    Neuroimmunomodulation 15:117-24. 2008
    ..We investigated the GABA-mediated suppression of the synergistic release of interleukin (IL)-6 due to interleukin 1-beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha)...
  91. ncbi Cationic nanoparticles induce caspase 3-, 7- and 9-mediated cytotoxicity in a human astrocytoma cell line
    Mariana G Bexiga
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin, Ireland
    Nanotoxicology 5:557-67. 2011
    ..to study the mechanism by which amine-modified polystyrene nanoparticles induce cell death in a human brain astrocytoma cell line...
  92. ncbi Automated diagnosis of brain tumours astrocytomas using probabilistic neural network clustering and support vector machines
    Dimitris Glotsos
    Department of Medical Physics, University of Patras, Rio Patras 26500, Greece
    Int J Neural Syst 15:1-11. 2005
    ..5%. Low, intermediate, and high-grade tumours were identified with 95%, 88.3%, and 91% accuracies respectively. The proposed algorithm could be used as a second opinion tool for the histopathologists...
  93. pmc Anti-tumor immune response correlates with neurological symptoms in a dog with spontaneous astrocytoma treated by gene and vaccine therapy
    G Elizabeth Pluhar
    Department of Veterinary Animal Clinical Sciences, University of Minnesota, St Paul, MN 55108, United States
    Vaccine 28:3371-8. 2010
    ..Gemistocytic astrocytoma (GemA) is a low-grade glioma that typically progresses to lethal malignancy despite conventional therapies...
  94. ncbi Advances in the management of subependymal giant cell astrocytoma
    Thomas L Beaumont
    Department of Neurological Surgery, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8057, St Louis, MO 63110, USA
    Childs Nerv Syst 28:963-8. 2012
    Subependymal giant cell astrocytoma (SEGA) is the most common central nervous system tumor in patients with tuberous sclerosis complex (TSC)...
  95. ncbi Paediatric high and low grade glioma: the impact of tumour biology on current and future therapy
    Darren Hargrave
    Paediatric Oncology Unit, Royal Marsden NHS Foundation Trust, Sutton, UK
    Br J Neurosurg 23:351-63. 2009
    ..Pilocytic astrocytoma, the most common childhood low grade brain tumour, has recently been shown to harbour an activated BRAF/MAPK/..
  96. ncbi Raman spectroscopic grading of astrocytoma tissues: using soft reference information
    Claudia Beleites
    CENMAT and DI3, University of Trieste, Italy
    Anal Bioanal Chem 400:2801-16. 2011
    ..classification models distinguish the surgically relevant classes "normal tissue" and "low" and "high grade astrocytoma" in Raman maps of moist bulk samples (80 patients) acquired with a fibre-optic probe...
  97. ncbi Prognostic significance of nuclear DJ-1 expression in astrocytoma
    Yoshiteru Miyajima
    Department of Molecular Diagnostics, Kitasato University School of Allied Health Sciences, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Anticancer Res 30:265-9. 2010
    ..We herein demonstrated for the first time that the DJ-1 molecule might therefore play an important role as a tumor suppressor in astrocytomas...
  98. pmc Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy
    Emmanuelle Huillard
    Department of Pediatrics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 109:8710-5. 2012
    ..significantly increased survival of mice after intracranial transplant of genetically relevant murine or human astrocytoma cells...
  99. ncbi Gene expression profiling of human gliomas reveals differences between GBM and LGA related to energy metabolism and notch signaling pathways
    Javier Margareto
    LEIA Foundation, Pharmaceutical Development Unit, Leonardo de Vinci, 11 Alava Technologic Park, 01510 Miñano, Alava, Spain
    J Mol Neurosci 32:53-63. 2007
    ..These types of studies represent a first step to deepen into the tumor physiology, which may potentially help for better and a more precise diagnosis of gliomas...
  100. ncbi Apparent diffusion coefficient histograms may predict low-grade glioma subtype
    Daniel J Tozer
    Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    NMR Biomed 20:49-57. 2007
    ..Fifteen patients with astrocytoma (AC) [11 male (mean age +/- standard deviation) 40 +/- 11 years], nine with oligodendroglioma (OD) (four male, ..
  101. ncbi Expression of HIF-1alpha and iNOS in astrocytic gliomas: a clinicopathological study
    E Giannopoulou
    Laboratory of Clinical Oncology, University of Patras Medical School, 26500, Rion, Greece
    In Vivo 20:421-5. 2006
    ..HIF-1 stimulates the production of NO through the induction of inducible NO synthase (iNOS)...

Research Grants66

  1. Tat and CDK9 on gene expression alterations coupled to HIV-1 Associated Dementia
    Xavier Grana; Fiscal Year: 2010
    ..We have investigated the effect of limiting CDK9 activity in a human astrocytoma cell line...
  2. Identifying underlying mechanisms of intracellular changes in response to caregiv
    MELANIE SARAH FLINT; Fiscal Year: 2013
    ..a primary malignant brain tumor (PMBT) and the five year survival of patients with the most common PMBT, an astrocytoma grade IV, is less than 25%...
  3. Slow cycling brain tumor cancer stem cells
    BRENT REYNOLDS; Fiscal Year: 2010
    ..Grade II low grade astrocytoma, with a mean patient survival of 5-15 years...
  4. Oncogene cooperation in glioma genesis
    Wei Zhang; Fiscal Year: 2013
    ..Secondary GBMs are believed to arise through anaplastic progression from lower grade astrocytomas (anaplastic astrocytoma, AA;and low-grade astrocytoma, A)...
  5. Extracellular Sulfatases As Novel Biomarkers For Early Detection of Cancer
    Joanna Phillips; Fiscal Year: 2013
    ..in particular, has been shown by the PIs of this proposal, to drive carcinogenesis in NSCLC and malignant astrocytoma through regulation of several cancer-promoting pathways...
  6. Targeted Delivery of a Novel Synthetic Curcumin Analog, EF24 to Glioblastoma and
    MAMORU NONE SHOJI; Fiscal Year: 2012
    ..by applicant): Glioblastoma (GBM) is the most common primary brain tumor and the most malignant form of astrocytoma (WHO grade IV)...
  7. A Bi-Institutional Pilot Study of Vaccinations for Patients with Low Grade Glioma
    Edward G Shaw; Fiscal Year: 2010
    ..efficiently induce anti-tumor T-cell responses in adults with either World Health Organization (WHO) grade II astrocytoma or oligoastrocytoma with poor prognostic factors...
  8. High-Grade Astrocytoma-specific Molecular Targeting
    Waldemar Debinski; Fiscal Year: 2013
    ..It is expected that these new means will increase the armamentarium of available agents controlling the progression and/or recurrence of the disease. ..
  9. RNA-based Immunotherapy Targeting Antigens Unique to Brain Tumor Stem Cells
    John H Sampson; Fiscal Year: 2012
    ..preparations will be evaluated for differential toxicity and efficacy in an inbred transgenic murine malignant astrocytoma model, in which a subpopulation of CD133(+) tumor cells with BTSC qualities have been identified and CD8(+) and ..
  10. Genetic Mouse Models of Glioma
    Luis F Parada; Fiscal Year: 2013
    ..We previously reported mouse models based on conditional inactivation of human astrocytoma-relevant tumor suppressors p53, Nf1, and Pten, wherein through somatic loss of heterozygosity, mutant mice ..
  11. Pesticide Exposure and Childhood Cancer Study
    Beate R Ritz; Fiscal Year: 2012
    ..diagnosed with certain cancers (acute myeloid leukemia, acute lymphoblastic leukemia, non Hodgkin lymphoma, astrocytoma, primitive neuroectodermal tumors, Wilms tumor, soft tissue sarcomas) and population-based controls...
  12. Neurotransmitter Regulation of Glial Cytokine Expression
    BRYAN SPANGELO; Fiscal Year: 2009
    ..We have demonstrated that IL-1 stimulates IL-6 release from C6 astrocytoma cells...
  13. Therapeutic Exploitation of Mutant BRAF for Astrocytoma
    Peter J Houghton; Fiscal Year: 2013
    ..Moreover, the metastatic potential and malignant transformation to a high-grade astrocytoma further contributes to the poor prognosis...
  14. Heparan sulfate proteoglycans as critical regulators of brain cancer malignancy
    Joanna Phillips; Fiscal Year: 2013
    ..are common in diverse cancers and the PI of this proposal has shown SULF2 can drive carcinogenesis in malignant astrocytoma through regulation of RTK signaling pathways...
  15. Dissecting Glioma Genesis through a Glial-Specific Mouse Model
    Wei Zhang; Fiscal Year: 2013
    ..growth factor beta (PDGFB), leads to the development and progression of two major types of glioma (astrocytoma and oligodendroglioma) (Dunlap et al., 2007)...
  16. Therapeutic Opportunities for Pediatric Astrocytoma
    Rosalind A Segal; Fiscal Year: 2013
    ..Towards this end, we will improve our understanding of astrocytoma biology and develop new diagnostic, prognostic and therapeutic tools for these tumors...
  17. Impact of molecular phenotype on glioma metabolism and growth
    Tracy Richmond McKnight; Fiscal Year: 2013
    ..of chromosomes 1p and 19q, (2) compare the metabolic profile and infiltration pattern of non-enhancing astrocytoma with differential expression of p53 and EGFR, and (3) Compare the metabolic and diffusion parameters of non-..
  18. Merlin regulation of spinal cord NSC function
    Cynthia Garcia; Fiscal Year: 2013
    ..Cancers of the spinal cord are uncommon neoplasms, the majority of which are glial cell tumors (ependymoma and astrocytoma) thought to arise from multipotent neuroglial progenitor (stem) cells...
  19. Amide Proton Transfer (APT) MRI of Brain Tumors at 3T
    Jinyuan Zhou; Fiscal Year: 2013
    ..remain universally fatal, with a median survival of 12-15 months for glioblastoma and 2-5 years for anaplastic astrocytoma. Limitations in neuroimaging complicate the clinical management of patients with gliomas, and impede efficient ..
  20. Dissecting Glioma Genesis through a Glial-Specific Mouse Model
    Wei Zhang; Fiscal Year: 2009
    ..growth factor beta (PDGFB), leads to development and progression of two major types of diffuse glioma (astrocytoma and oligodendroglioma) (published in Dunlap et al., PNAS, 2007)...
  21. BRAF Mutation in Malignant Astrocytoma Origin, Evolution, and Response to Therapy
    Claudia Petritsch; Fiscal Year: 2013
    ....
  22. Improving therapy of glioblastoma multiforme by enhancing therapeutic drug delive
    Michael R McDevitt; Fiscal Year: 2013
    ..GBM is a malignant astrocytoma and one of the most common glial tumors...
  23. TAS::75 0849::TAS DEVELOPMENT OF ROS KINASE INHIBITORS - PHASE I SBIR TOPIC 255
    Dorre A Grueneberg; Fiscal Year: 2010
    ..kinase activity and the development and/or progression of astrocytic tumors such as glioblastoma, a grade IV astrocytoma, based on genetic findings, gene expression data, and animal models...
  24. Modeling and microsystems approach to glioma invasion
    Steven S Rosenfeld; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glioblastoma (Grade IV Astrocytoma;GBM) is a devastating cancer of the brain with median survival of 15 months, and 5% long-term survival...
  25. MR Investigation of IDH Mutation and Its Marker 2-HG in Brain Tumor Patients
    Hui Mao; Fiscal Year: 2013
    ..The high grade astrocytoma (WHO IV) and primary glioblastoma multiforme (GBM) or secondary GBM rising from diffuse low grade gliomas are ..
  26. Genome-wide promoter methylation profiling of glioma
    Albert Lai; Fiscal Year: 2012
    ..The specific aims are: 1) to understand the role of promoter methylation in astrocytoma transformation by comparing genome-wide methylation profiles of low grade astrocytomas, anaplastic astrocytomas,..
  27. Pten and P13K regulation of growth and neoplasia in the brain
    Suzanne J Baker; Fiscal Year: 2012
    ..inactivation influences proliferation, survival and growth in astrocytes and in an in vivo model of high-grade astrocytoma. We will test the response of transformed astrocytes to inhibitors of the PI3k signaling pathway in vitro and ..
  28. Identifying Key Genes that cause Aggressive Brain Cancer
    Changwon Yoo; Fiscal Year: 2013
    ..e., grade II astrocytoma, grade III astrocytoma, and glioblastoma (grade IV astrocytoma))...
  29. Osteopontin-mediated invasion and dissemination in central nervous system lymphom
    Han W Tun; Fiscal Year: 2013
    ..results will have great implications for other OPN- expressing primary brain tumors such as glioblastoma and astrocytoma. Moreover, there will be many implications for cancer treatment in general as OPN is ubiquitously expressed by ..
  30. Role of Nuclear Factor I A (NFIA) gene in glioma
    Hae Ri Song; Fiscal Year: 2013
    ..I therefore hypothesize that NFIA has a role in astrocytoma growth, which may depend on the NFIA splice variants expressed in the tumors...
  31. Role of Ascl1 in glioma
    Tou Yia Vue; Fiscal Year: 2013
    ..upregulated in a number of cancers, including lung cancers with neuroendocrine features and malignant astrocytoma. Mouse models of malignant astrocytoma recently indicated that neural progenitors may be the cells of origin ..
  32. UNDERSTANDING TRAIL SENSITIVITY IN HUMAN GLIOMA
    Russell O Pieper; Fiscal Year: 2010
    ..define TRAIL sensitivity in a panel of short term cultures of primary human low grade gliomas (LGG), anaplastic astrocytoma (AA), and GBM, and to determine if levels/activity of Ras pathways and/or FLIPs correlate with TRAIL ..
  33. High-resolution DT-MRI for differentiation of malignant glioma from radiation nec
    Jinyuan Zhou; Fiscal Year: 2010
    ..i) many low-grade and even some high-grade gliomas (10% of glioblastoma multiforme and 20-30% of anaplastic astrocytoma) demonstrate no Gd-enhancement, and (ii) separating recurrent tumor from other causes of BBB dysfunction, such ..
  34. Identification of MRS Markers of Glioma Progression
    Tracy Richmond McKnight; Fiscal Year: 2010
    ..stems from the fact that patients with oligodendroglioma (OD) enjoy a more favorable outcome than patients with astrocytoma. The current proposal seeks to evaluate the effectiveness of MRS for post-surgical prediction of the behavior ..
  35. Astrocytic Cancers: How, When, Where?
    Terry van Dyke; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Astrocytomas, including low grade astrocytoma (grade II), anaplastic (high grade) astrocytoma (grade III) and glioblastoma (grade IV), are the most common human brain tumor...
  36. Cannabinoid Signaling System in Microglial Cell
    Nephi Stella; Fiscal Year: 2013
    ..at GPR125 represent new pharmacological tools to study the involvement of microglia in controlling malignant astrocytoma pathogenesis...
  37. Development of novel thiobarbituric acid analogs for malignant brain tumors
    Sang Y Lee; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Glioblastoma multiforme (GBM, grade IV astrocytoma) is one of the most common malignant glioma among brain tumors, accounting for 30-40% of primary brain tumors...
  38. Perivascular Invasion of GBMs
    Gabriele Bergers; Fiscal Year: 2010
    ..This project will test the hypothesis that perivascular GBM dissemination is orchestrated by the interaction of astrocytoma-specific factors and brain-specific blood vessel components, and that the onset of angiogenesis restricts this ..
  39. THERAPEUTIC MODULATION OF ANGIOGENESIS IN HUMAN GLIOMAS
    Erwin G Van Meir; Fiscal Year: 2011
    ..in which the goals were to broadly examine the role of the IL-8,TSP-1 and BAI-1 angiogenesis modulators in astrocytoma progression and therapy...
  40. Regulation of neural cell volume by thrombin receptors
    Tooba Cheema; Fiscal Year: 2006
    ..acting via specific receptors, can enhance the release of taurine from hypotonically-stressed human 1321N1 astrocytoma and primary cultures of rat astrocytes...
  41. MOLECULAR AND FUNCTIONAL ANALYSIS OF HUMAN FGF 1
    Ing Ming Chiu; Fiscal Year: 2000
    ..is expressed in gliomas, with a higher level in the more malignant glioblastoma multiform than in anaplastic astrocytoma. Other laboratories have demonstrated that high level expression of FGFR1 is associated with malignant ..
  42. AGT DEPLETION FOR THERAPY OF CNS TUMORS
    Jennifer Quinn; Fiscal Year: 2004
    ..failing to cure all patients with glioblastoma multiforme and the majority of patients with anaplastic astrocytoma. This failure is due almost exclusively to de novo or acquired resistance to chemotherapy with subsequent tumor ..
  43. STRESS PROTEIN MODULATION OF MEASLES VIRAL ENCEPHALITIS
    Daphne Vasconcelos; Fiscal Year: 1999
    ..In objective I, the role of hsp72 in modulating MV-cell interaction will be examined in astrocytoma and neuroblastoma cell lines...
  44. Development of Novel Inhibitors of Ganglioside Biosynthesis
    Brett E Crawford; Fiscal Year: 2010
    ..biosynthesis will prevent or slow the growth of neural crest-derived tumors (neuroblastoma, melanoma, and astrocytoma)...
  45. PROTEIN KINASE C AND GLIAL TUMOR GROWTH
    Ian Pollack; Fiscal Year: 1999
    ..tumors and, conversely, that inhibition of this second messenger may provide a novel strategy for blocking astrocytoma proliferation...
  46. ACTIVE IMMUNOTHERAPY FOR GLIOBLASTOMA
    John Yu; Fiscal Year: 2004
    ..these preclinical studies into clinical protocols for patients with glioblastoma multiforme and anaplastic astrocytoma. We are completing a preliminary phase I trial based on a dendritic cell therapeutic strategy...
  47. SECOND MESSENGERS IN ASTROCYTES AND PRECURSOR CELLS
    Bridget Shafit Zagardo; Fiscal Year: 1991
    ..of agents which modulate cAMP or protein kinase C on GFAP RNA in primary astrocyte cultures and in the human astrocytoma cell line HTB-17 are being studies...
  48. Therapy of Temodar plus O6-Benzylguanine in Malignant G*
    Jennifer Quinn; Fiscal Year: 2004
    ..failing to cure all patients with glioblastoma multiforme and the majority of patients with anaplastic astrocytoma. This failure is due almost exclusively to de novo or acquired resistance to chemotherapy resulting in ..
  49. Metabolic Polymorphisms and Survival from Brain Tumors
    Melissa Bondy; Fiscal Year: 2004
    ..have improved the outcome, especially in the chemotherapy-sensitive group of tumors such as anaplastic astrocytoma and anaplastic oligodendroglioma...
  50. A Phase I Study of TM601 in Recurrent Malignant Glioma Under IND #77,825 Submitte
    AMY BOCK; Fiscal Year: 2009
    ..12,740 people will die from these tumors, and high grade-grade gliomas (glioblastoma multiforme, anaplastic astrocytoma and oligo-astrocytoma) are the most lethal forms of primary brain tumors...
  51. Allogeneic glioma vaccine using TGF-beta knockouts
    Habib Fakhrai; Fiscal Year: 2009
    ..The vaccine generated in this manner will be used to immunize patients with stage IV astrocytoma (glioblastoma multiforme and gliosarcoma) in a Phase II/III clinical trial with the goal of inducing antitumor ..
  52. MODIFICATION OF TUMOR RESPONSE TO LOCAL IRRADIATION
    Jay Loeffler; Fiscal Year: 1990
    A major research effort is to study the response to fractionated irradiation of xenografts of human astrocytoma (high grade), squamous cell carcinoma, and mammary adenocarcinoma growing in nude mice...
  53. Role of LRP in Astrocytoma Migration
    Isa Hussaini; Fiscal Year: 2007
    ..Understanding the role of LRP in the migration and invasion astrocytic tumors will provide information on possible specific targets for therapeutic intervention. [unreadable] [unreadable]..
  54. GENE EXPRESSION BASED CLASSIFICATION OF GLIAL TUMORS
    Stanley Nelson; Fiscal Year: 2004
    ..data and the technology for cDNA arrays provides a platform for the large scale analysis of gene expression in astrocytoma. We propose to identify a set of genes that will allow the molecular characterization of brain tumors by using ..
  55. GLIAL FILAMENT ASSOCIATED PROTEINS IN HUMAN ASTROCYTOMAS
    Omar Skalli; Fiscal Year: 2006
    Intermediate filaments (IF; also called glial filaments in astrocytes) are a major cytoskeletal component of astrocytoma cells...
  56. Identification of Differentially Expressed Proteomes in Human Astrocytomas
    BRIAN BALGLEY; Fiscal Year: 2006
    ..fixation and staining procedures, further limiting the ability to perform effective proteome studies from human astrocytoma biopsies...
  57. MITOGENIC NEUROPEPTIDE RECEPTORS IN BRAIN TUMORS
    Mohammed Sharif; Fiscal Year: 2000
    Progression of low grade astrocytoma to more aggressive high grade glioblastoma is associated with progressively worse prognosis, and even successful treatment of low grade tumors with conventional chemo- radiotherapy can be associated ..
  58. The Fox M1 in Human Glioma Development and Progression
    Suyun Huang; Fiscal Year: 2009
    ..Enforced FoxM1 expression in anaplastic astrocytoma cells promoted their progression into glioblastomas in nude mouse models, and suppressed FoxM1 expression ..
  59. ASTROCYTOMA MOTILITY AND INVASION
    Daniel Silbergeld; Fiscal Year: 2000
    ..Surprisingly, little effort has been made to investigate the cellular and molecular biology of invading astrocytoma cells...
  60. SHP2 and SIRP modulate erbB signals in astrocytes
    DONALD O ROURKE; Fiscal Year: 2005
    ..Our laboratory has identified a novel mechanism of negative regulation of P13-K activation in astrocytoma cells involving SHP2 and SIRP...
  61. Phase I Study of Dendritic Cell Immunotherapy
    Linda Liau; Fiscal Year: 2002
    Malignant gliomas (anaplastic astrocytoma and glioblastoma multiforme) are the most frequent primary brain tumors in adults and account for about 2 percent of all cancers...
  62. THERAPY & MIGRATION OF HUMAN MALIGNANT ASTROCYTOMAS
    JERALD BERNSTEIN; Fiscal Year: 1991
    ..We will utilize an established neural xenografting model of fresh malignant grade -3-4 human astrocytoma cells into cortical pockets in normal and athymic rats...
  63. CELL SURFACE ANTIGENS GLIAL BRAIN TUMOR CELLS
    Darell Bigner; Fiscal Year: 1980
    Surface antigens of human glial brain tumor cells and VM murine spontaneous anaplastic astrocytoma cells were investigated by binding (indirect membrane immunofluorescence) and complement-dependent cytotoxic antibody (14C-nicotinamide ..
  64. FAK AND CAS AND ASTROCYTOMA MIGRATION/INVASION
    Candece Gladson; Fiscal Year: 2003
    The long-term goal of our research is to establish a model of the invasion of the normal brain by malignant astrocytoma tumors that permits the development of specific and effective therapies...
  65. The Role of Lyn in Glioma Progression and Migration
    Candece Gladson; Fiscal Year: 2009
    ..Lyn: (i) The activity of Lyn is higher in glioblastoma (Grade IV) tumor biopsies, as compared to anaplastic astrocytoma (Grade III) tumor biopsies and normal brain;(") Lyn is specifically activated by the cooperation of ligated ..
  66. GLIAL FILAMENT ASSOCIATED PROTEINS IN HUMAN ASTROCYTOMAS
    Omar Skalli; Fiscal Year: 2000
    ..of expression of GFAP (one of the proteins which constitute glial filaments) affect the growth and shape of astrocytoma cells...